polyradiculoneuropathy

Summary

Summary: Diseases characterized by injury or dysfunction involving multiple peripheral nerves and nerve roots. The process may primarily affect myelin or nerve axons. Two of the more common demyelinating forms are acute inflammatory polyradiculopathy (GUILLAIN-BARRE SYNDROME) and POLYRADICULONEUROPATHY, CHRONIC INFLAMMATORY DEMYELINATING. Polyradiculoneuritis refers to inflammation of multiple peripheral nerves and spinal nerve roots.

Top Publications

  1. Khalili Shirazi A, Atkinson P, Gregson N, Hughes R. Antibody responses to P0 and P2 myelin proteins in Guillain-Barré syndrome and chronic idiopathic demyelinating polyradiculoneuropathy. J Neuroimmunol. 1993;46:245-51 pubmed
    ..38 patients with acute Guillain-Barré syndrome (GBS), 32 patients with chronic idiopathic demyelinating polyradiculoneuropathy (CIDP), 31 patients with other neuropathies (ONP) and 26 normal control (NC) subjects...
  2. Korn Lubetzki I, Abramsky O. Acute and chronic demyelinating inflammatory polyradiculoneuropathy. Association with autoimmune diseases and lymphocyte response to human neuritogenic protein. Arch Neurol. 1986;43:604-8 pubmed
    Of 66 patients (31 female and 35 male) with demyelinating inflammatory polyradiculoneuropathy (DIP), 12% (8/66) had a chronic relapsing and/or progressive course (CR-DIP) and 88% (58/66) had an acute monophasic illness (acute Guillain-..
  3. Hemachudha T, Griffin D, Chen W, Johnson R. Immunologic studies of rabies vaccination-induced Guillain-Barré syndrome. Neurology. 1988;38:375-8 pubmed
    ..None of the sera had detectable antibody to P2 protein. We conclude that patients with GBS constitute a heterogeneous population and that different target antigens may serve as a focus for this presumed autoimmune disease...
  4. Oh S, LaGanke C, Powers R, Wolfe G, Quinton R, Burns D. Multifocal motor sensory demyelinating neuropathy: inflammatory demyelinating polyradiculoneuropathy. Neurology. 2005;65:1639-42 pubmed
    ..This study showed that MADSAMN is an inflammatory demyelinating polyradiculoneuropathy that shares histologic features observed in chronic inflammatory demyelinating polyradiculoneuropathy and ..
  5. El Moutawakil B, Rafai M, Gam I, Tahiri J, Rhimou A, Slassi I. [Crohn's disease presenting with recurrent acute polyradiculoneuropathy]. Rev Neurol (Paris). 2007;163:244-6 pubmed
    ..The neurological manifestations of Crohn's disease are rare, dominated by multiple mononeuropathies and the abnormalities of the white matter. Polyradiculoneurities remain exceptional...
  6. Cuddon P. Electrophysiologic assessment of acute polyradiculoneuropathy in dogs: comparison with Guillain-Barré syndrome in people. J Vet Intern Med. 1998;12:294-303 pubmed
    ..sensory nerve as well as ventral nerve root function were performed on 12 dogs with suspected acute canine polyradiculoneuropathy (ACP) at different stages and with different severity of disease...
  7. LaChance D, Lennon V, Pittock S, Tracy J, Krecke K, Amrami K, et al. An outbreak of neurological autoimmunity with polyradiculoneuropathy in workers exposed to aerosolised porcine neural tissue: a descriptive study. Lancet Neurol. 2010;9:55-66 pubmed publisher
    ..We aimed to describe the pathogenic and immunological characteristics of this illness...
  8. Adjemian J, Howell J, Holzbauer S, Harris J, Recuenco S, McQuiston J, et al. A clustering of immune-mediated polyradiculoneuropathy among swine abattoir workers exposed to aerosolized porcine brains, Indiana, United States. Int J Occup Environ Health. 2009;15:331-8 pubmed
    In November 2007 a novel neuropathy, immune-mediated polyradiculoneuropathy (IP), was identified among workers at a Minnesota swine abattoir where a unique compressed air technique was used to remove porcine brains...
  9. Mercatello A, Simplot A, Terrier A, Blanc P, Guibaud S, Robert D. [Electrophoresis of cholinesterases of the cerebrospinal fluid in the Guillain-Barré syndrome]. Presse Med. 1990;19:61-4 pubmed
    ..Cerebrospinal fluid electrophoresis could be used as a prognosis factor...

More Information

Publications62

  1. Dalakas M. Intravenous immunoglobulin in the treatment of autoimmune neuromuscular diseases: present status and practical therapeutic guidelines. Muscle Nerve. 1999;22:1479-97 pubmed
    ..Finally, safety issues, risk factors, adverse reactions, spurious results or serological tests, and practical guidelines associated with the administration of IVIg in the treatment of neuromuscular disorders are presented...
  2. Harloff A, Voigt S, Hetzel A, Glocker F, Els T. Severe axonal polyradiculoneuritis and brainstem encephalitis due to Mycoplasma pneumoniae infection. Eur J Neurol. 2002;9:542-3 pubmed
  3. Nara T, Mishima M, Nozaki H, Hamano S, Maekawa K. [A case of acute polyradiculoneuritis associated with autonomic involvement of the pupils]. No To Hattatsu. 1991;23:284-8 pubmed
    ..Parasympathetic dysfunction of pupils with ocular palsies preceded neuropathy of limbs at the onset. Thereafter, sympathetic dysfunction of pupils without ocular palsies was revealed by pupillography at the 2nd attack of limb palsies...
  4. Alaedini A, Sander H, Hays A, Latov N. Antiganglioside antibodies in multifocal acquired sensory and motor neuropathy. Arch Neurol. 2003;60:42-6 pubmed
    ..Multifocal acquired demyelinating sensory and motor neuropathies are considered autoimmune and responsive to immunotherapy. In the absence of demyelination, however, they are considered idiopathic if no other cause is found...
  5. Willison H, Stoll G, Toyka K, Berger T, Hartung H. Autoimmunity and inflammation in the peripheral nervous system. Trends Neurosci. 2002;25:127-9 pubmed
    ..Peripheral Nerve Society Biennial Meeting, organized in conjunction with the Austrian Federal Ministry of Education, Research and Culture, held at Telfs, Tyrol, Austria from 8-12 September 2001...
  6. Martic V, Lepic T. Recurrence of childhood Guillain-Barré syndrome after a long asymptomatic interval: a case report. J Clin Neuromuscul Dis. 2007;9:256-61 pubmed
    ..The reported case adds to a small series of cases of recurrent Guillain-Barré syndrome after a long asymptomatic period. In such cases, the distinction from chronic inflammatory demyelinating polyradiculoneuropathy should be made.
  7. Mazzoni A, Pardi C, Bortoli M, Mariotti M, Uncini Manganelli C, Vanacore R, et al. Plasma exchange for polyradiculoneuropathy following kidney transplantation: a case report. Transplant Proc. 2004;36:716-7 pubmed
    We describe a case of polyradiculoneuropathy (PRN) following living donor kidney transplantation, without clinical evidence of preexisting infection...
  8. Kuijf M, Eurelings M, Tio Gillen A, Van Doorn P, van den Berg L, Hooijkaas H, et al. Detection of anti-MAG antibodies in polyneuropathy associated with IgM monoclonal gammopathy. Neurology. 2009;73:688-95 pubmed publisher
    ..In this study, the diagnostic accuracy of a new and more practical ELISA to detect these antibodies was validated...
  9. Alvira Duplá M, Mayayo Artal E. [Paraneoplastic syndromes with peripheral nerve involvement]. Rev Neurol. 2000;31:1223-5 pubmed
    ..To review the paraneoplastic complications described affecting the peripheral nervous system...
  10. Montgomery S, Gabriel R, James D, Hawley C, Burkitt P. The specificity of the zimelidine reaction. Int Clin Psychopharmacol. 1989;4:19-23 pubmed
    ..Both patients remained well during uneventful long term treatment with fluoxetine...
  11. Pozniak A, Lobzin I, Mikhaĭlenko A, Mudritskiĭ V, Nuralova I, Makarov V. [Acute chlamydial lesions of the nervous system: etiology, diagnosis, clinical aspects]. Klin Med (Mosk). 2002;80:31-4 pubmed
    ..Development of acute neuroinfection is accompanied by sluggish chlamydial infection of the viscera...
  12. Garces Sanchez M, Dyck P, Kyle R, Zeldenrust S, Wu Y, Ladha S, et al. Antibodies to myelin-associated glycoprotein (anti-Mag) in IgM amyloidosis may influence expression of neuropathy in rare patients. Muscle Nerve. 2008;37:490-5 pubmed publisher
    ..They do not appear to affect the occurrence or expression of polyneuropathy, except possibly in occasional cases with WB positivity...
  13. Pestronk A, Choksi R, Yee W, Kornberg A, Lopate G, Trotter J. Serum antibodies to heparan sulfate glycosaminoglycans in Guillain-Barré syndrome and other demyelinating polyneuropathies. J Neuroimmunol. 1998;91:204-9 pubmed
  14. Wuest D, Goldfinger D. Plasmapheresis in the treatment of acute relapsing inflammatory demyelinating polyradiculoneuropathy associated with human immunodeficiency virus infection: a case report. J Clin Apher. 1988;4:149-51 pubmed
    Neurologic complications, including both the acute and chronic forms of inflammatory demyelinating polyradiculoneuropathy (IDP) are becoming more prevalent among patients with the acquired immunodeficiency syndrome (AIDS) and AIDS-related-..
  15. Watanabe T, Matsuura O, Natsume J, Kubota T, Nakashima S, Aso K, et al. [Dramatic improvement with immunoabsorption therapy in a 7-year-old girl with severe Guillain-Barré syndrome after unsuccessful gammaglobulin therapy]. No To Hattatsu. 1998;30:255-60 pubmed
    ..The immunoabsorption therapy caused hemolysis and decrease of serum fibrinogen, but no serious complications. The clinical course of this patient suggests the efficacy of immunoabsorption therapy in GBS...
  16. Boyle K, Azari M, Cheema S, Petratos S. TNFalpha mediates Schwann cell death by upregulating p75NTR expression without sustained activation of NFkappaB. Neurobiol Dis. 2005;20:412-27 pubmed
    ..Immature Schwann cells express a high level of p75NTR and as a consequence are susceptible to extracellular death stimuli because of the lack of sustained NFkappaB translocation...
  17. Zezos P, Mpoumponaris A, Koutsopetras P, Vounotrypidis P, Molyvas E, Vadikolias K, et al. Acute motor sensory polyneuropathy (AMSAN) complicating active ulcerative colitis with a patchy distribution. Acta Gastroenterol Belg. 2007;70:226-30 pubmed
    ..Peripheral polyneuropathy is a rare extraintestinal manifestation of ulcerative colitis and it is probably associated with an autoimmune pathogenetic mechanism...
  18. Jarmundowicz W, Tabakow P, Załuski R, Rutowski R. [Pseudocyst of the neck after traumatic avulsion of spinal C6-T2 nerve roots--case report]. Neurol Neurochir Pol. 2003;37:1325-31 pubmed
    ..The authors also point out that in case of any of cerebrospinal fluid leakage, special attention should be paid to stopping the escape of CSF...
  19. Kiprov D, Pfaeffl W, Parry G, Lippert R, Lang W, Miller R. Antibody-mediated peripheral neuropathies associated with ARC and AIDS: successful treatment with plasmapheresis. J Clin Apher. 1988;4:3-7 pubmed
    ..These results suggest that the peripheral neuropathy associated with ARC and AIDS is immunologically mediated and that plasma exchange is an effective treatment in a subgroup of patients with this disorder...
  20. Shetty G, Murari A, Song H, Lee S, Yang J. Neurofibromatous sensory neuropathy of the thigh in a 7-year-old boy. Arch Orthop Trauma Surg. 2008;128:1093-7 pubmed
  21. Herinckx C, Deggouj N, Gersdorff M, Evrard P, Guerit J. [Guillain-Barré syndrome and hypacusia]. Acta Otorhinolaryngol Belg. 1995;49:63-7 pubmed
    ..A child presenting Guillain-Barré's syndrome, together with bilateral hearing loss is presented. The incidence of hypoacusis is unknown. The necessity of behavioural audiometry and electrophysiologic testing is stressed...
  22. Chiu H, Trence D. Diabetic neuropathy, the great masquerader: truncal neuropathy manifesting as abdominal pseudohernia. Endocr Pract. 2006;12:281-3 pubmed
    ..To describe a patient with diabetic truncal neuropathy and suggest a helpful diagnostic approach to this entity...
  23. Luijten J, Reijneveld de Jong S, Teerlink T, Camps V, Osterhaus A, Uytdehaag A. Monoclonal antibodies to P2 basic protein and their use in the investigation of some aspects of the Guillain-Barré syndrome. J Neurol Sci. 1988;86:265-76 pubmed
    ..In sera of twenty GBS patients no such Ab2 antibodies could be demonstrated. Epitopes present on cytomegalo virus- or Epstein-Barr virus-infected cells, which may play a part in triggering GBS, were not recognised by the two MAbs...
  24. Frey B, Fopp M. [Therapeutic plasmapheresis--a critical review in the light of the current literature]. Schweiz Med Wochenschr. 1993;123:1725-35 pubmed
  25. Hannawi Y, Goldsmith C, Kass J, Olar A, Ubogu E, Kalkonde Y. A case of severe chronic progressive axonal polyradiculoneuropathy temporally associated with anti-CV2/CRMP5 antibodies. J Clin Neuromuscul Dis. 2013;15:13-8 pubmed publisher
    ..We report a fatal case of severe chronic progressive axonal polyradiculoneuropathy in association with this antibody.
  26. Molenaar D, Vermeulen M, de Haan R. Diagnostic value of sural nerve biopsy in chronic inflammatory demyelinating polyneuropathy. J Neurol Neurosurg Psychiatry. 1998;64:84-9 pubmed
  27. Dalakas M. Pathophysiology of autoimmune polyneuropathies. Presse Med. 2013;42:e181-92 pubmed publisher
  28. Schwerer B, Neisser A, Bernheimer H. Distinct immunoglobulin class and immunoglobulin G subclass patterns against ganglioside GQ1b in Miller Fisher syndrome following different types of infection. Infect Immun. 1999;67:2414-20 pubmed
    ..Thus, the origin of antibodies against GQ1b in MFS may be determined by the type of infectious agent that precipitates the disease...
  29. Karam C. Harlequin syndrome in a patient with putative autoimmune autonomic ganglionopathy. Auton Neurosci. 2016;194:58-9 pubmed publisher
    ..An autoimmune etiology should be considered in patients with Harlequin syndrome and immunomodulatory treatment could be attempted, especially when there is evidence of a more generalized autoimmune autonomic ganglionopathy. ..
  30. Faber C, Notermans N, Wokke J, Franssen H. Entrapment in anti myelin-associated glycoprotein neuropathy. J Neurol. 2009;256:620-4 pubmed publisher
    ..In conclusion, increased sensitivity for entrapment may occur in anti-MAG neuropathy and contribute to part of the nerve damage...
  31. Duning T, Kraus J, Schäbitz W. [Acute polyneuritis and polyradiculoneuritis: uncommon causes and their pathomechanisms]. Fortschr Neurol Psychiatr. 2009;77:218-27 pubmed publisher
    ..We provide a detailed review of the pertinent literature discussing possible pathomechanisms, its clinical associations and possible dispositions...
  32. Kashyap A, Anand K, Kashyap S. Guillain-Barré syndrome. Lancet. 2006;367:472; author reply 473-4 pubmed
  33. Yuki N, Tagawa Y. Acute cytomegalovirus infection and IgM anti-GM2 antibody. J Neurol Sci. 1998;154:14-7 pubmed
    ..Our results did not support the conclusion of Irie et al. that anti-GM2 antibodies were closely associated with acute CMV infection in GBS, but acute CMV infection, with and without GBS, was associated with IgM anti-GM2 antibody...
  34. Cabrera Lima A, Estrada R, Santiago Luis R, Alfaro I, Gonzalez A, Galarraga Inza J. [Inflammatory demyelinating chronic polyneuropathy: a contribution to the characterization of the disease]. Rev Neurol. 1999;28:772-8 pubmed
    ..We evaluated its clinical and laboratory findings, to contribute to its characterization in our environment...
  35. Kanda T, Yamawaki M, Iwasaki T, Mizusawa H. Glycosphingolipid antibodies and blood-nerve barrier in autoimmune demyelinative neuropathy. Neurology. 2000;54:1459-64 pubmed
    ..To evaluate morphologic changes in small endoneurial vessels in patients with autoimmune demyelinative neuropathy and antiglycosphyngolipid antibodies...
  36. Escorial Moya C, Rodríguez Baño J, Borobio M, Izquierdo G. [Opsoclonus secondary to encephalopolyradiculoneuritis due to Mycoplasma pneumoniae]. Neurologia. 2004;19:74-6 pubmed
    ..This case illustrates the possibility that M. pneumoniae may produce a predominantly neurological disease and the need to include this infection in the differential diagnosis of opsoclonus, or polyradiculoneuritis...
  37. Kraus J, Baumeier A, Boentert M, Husstedt I, Nabavi D, Ringelstein E, et al. Acute toxic polyradiculopathy after exorbitant intracarotid substance abuse. J Neurol. 2006;253:815-6 pubmed
  38. Chiba Y, Xu A, Li L, Lei T, Takezaki T, Hagiwara A, et al. Poliomyelitis surveillance in Shandong Province, China, 1990-92. Bull World Health Organ. 1994;72:915-20 pubmed
    ..As the prevalence of wild poliovirus declines in China, reliable laboratory support needs to be established and adequately sensitive and specific AFP surveillance be developed if poliomyelitis is to be eradicated...
  39. Hartung H, Lehmann H, Kieseier B, Hughes R. Novel treatment for immune neuropathies on the horizon. J Peripher Nerv Syst. 2011;16:75-83 pubmed publisher
    ..Here, we review the available clinical data as well as the scientific rationale and expected benefits and risks for these strategies...
  40. Holzbauer S, Devries A, Sejvar J, Lees C, Adjemian J, McQuiston J, et al. Epidemiologic investigation of immune-mediated polyradiculoneuropathy among abattoir workers exposed to porcine brain. PLoS ONE. 2010;5:e9782 pubmed publisher
    In October 2007, a cluster of patients experiencing a novel polyradiculoneuropathy was identified at a pork abattoir (Plant A)...
  41. Tumani H, Reiber H, Nau R, Prange H, Kauffmann K, Mader M, et al. Beta-trace protein concentration in cerebrospinal fluid is decreased in patients with bacterial meningitis. Neurosci Lett. 1998;242:5-8 pubmed
    ..Beta-trace may be a useful tool for studying the pathophysiology of bacterial meningitis...
  42. Gambelli S, Ginanneschi F, Malandrini A, Palmeri S, Berti G, Desiderio P, et al. Antibodies to dorsal root ganglia and olfactory cells in a patient with chronic sensory neuropathy and anosmia. J Neurol Sci. 2004;221:105-8 pubmed
    ..Clinical and laboratory data suggested a slow autoimmune process affecting dorsal root ganglion and olfactory cells...
  43. Berlot G, Tomasini A, Silvestri L, Gullo A. Plasmapheresis in the critically ill patient. Kidney Int Suppl. 1998;66:S178-81 pubmed
    ..The firmly accepted and the possible indications for these techniques in critically ill patients are reviewed and discussed, as well as their complications and possible side effects...
  44. Richette P, Dieude P, Damiano J, Lioté F, Orcel P, Bardin T. Sensory neuropathy revealing necrotizing vasculitis during infliximab therapy for rheumatoid arthritis. J Rheumatol. 2004;31:2079-81 pubmed
  45. Tackenberg B, Lünemann J, Steinbrecher A, Rothenfusser Korber E, Sailer M, Bruck W, et al. Classifications and treatment responses in chronic immune-mediated demyelinating polyneuropathy. Neurology. 2007;68:1622-9 pubmed
    ..Chronic immune-mediated demyelinating polyneuropathy (CIP) represents a heterogeneous pool of motor, sensory, sensorimotor, symmetric, or asymmetric syndromes...
  46. Zhang Z, Zhang Z, Fauser U, Schluesener H. Distribution of Foxp3(+) T-regulatory cells in experimental autoimmune neuritis rats. Exp Neurol. 2009;216:75-82 pubmed publisher
    ..These data not only suggests a protective role of Foxp3(+) cells in EAN but also provides a potential way to alter localization of Foxp3(+) cells in vivo...
  47. Roubertie A, Soete S, Meyer P, Echenne B, Rivier F, Langlois C. [Acute motor deficit in childhood: diagnosis management]. Arch Pediatr. 2010;17:325-32 pubmed publisher
  48. Vetrugno R, Liguori R, D Alessandro R, D Angelo R, Alessandria M, Montagna P. Axial myoclonus in paraproteinemic polyneuropathy. Muscle Nerve. 2008;38:1330-5 pubmed publisher
    ..Plasmapheresis substantially reduced the frequency and intensity of axial myoclonic jerks. In our patient, propriospinal myoclonus was associated with anti-MAG polyneuropathy, but the causal relationship remains unclear...
  49. Pou Serradell A. [Acquired dysimmune neuropathies. Clinical symptoms and classification]. Rev Neurol. 2000;30:501-10 pubmed
    ..This confirms their dysimmune nature and also offers unforeseen possibilities for the comprehension of etiopathogenic mechanisms and possible classifications of specific etiopathogenic factors...
  50. Oh S, Kurokawa K, de Almeida D, Ryan H, Claussen G. Subacute inflammatory demyelinating polyneuropathy. Neurology. 2003;61:1507-12 pubmed
    ..To report the clinical, electrophysiologic, and histologic characteristics of subacute inflammatory demyelinating polyneuropathy (SIDP) and to present the diagnostic criteria of this disease...
  51. Endo K, Suzuki N, Ikenishi T, Aoki M, Itoyama Y. Intravenous immunoglobulin treatment successfully improved subacute progressive polyradiculoneuropathy with polyclonal gammopathy. Intern Med. 2009;48:2037-9 pubmed
    ..conduction study and enhanced MRI findings, we diagnosed him as suffering from immune-mediated subacute polyradiculoneuropathy with polyclonal gammopathy, which might be related to Guillain-Barré syndrome...
  52. Evers S, Engelien A, Karsch V, Hund M. Secondary hyperkalaemic paralysis. J Neurol Neurosurg Psychiatry. 1998;64:249-52 pubmed
    ..Symptoms promptly resolve after haemodialysis or after glucose and insulin infusion. Only three out of 18 patients reviewed died, because of cardiopulmonary complications. Thus the prognosis of secondary hyperkalaemic paralysis is good...
  53. Blaser M. Epidemiologic and clinical features of Campylobacter jejuni infections. J Infect Dis. 1997;176 Suppl 2:S103-5 pubmed
    ..The high incidence of C. jejuni infections and their propensity to invade tissue and to induce inflammation are compatible with a role in the causation of Guillain-Barré syndrome...