cns demyelinating autoimmune diseases

Summary

Summary: Conditions characterized by loss or dysfunction of myelin (see MYELIN SHEATH) in the brain, spinal cord, or optic nerves secondary to autoimmune mediated processes. This may take the form of a humoral or cellular immune response directed toward myelin or OLIGODENDROGLIA associated autoantigens.

Top Publications

  1. Dale R, de Sousa C, Chong W, Cox T, Harding B, Neville B. Acute disseminated encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children. Brain. 2000;123 Pt 12:2407-22 pubmed
    ..These differences in the presentation of ADEM/MDEM compared with multiple sclerosis may help in the prognosis given to families regarding the possibility of later development of multiple sclerosis...
  2. Ohta M, Ohta K. [Immunologic tests: Myelin basic protein and anti-myelin basic protein antibody]. Nihon Rinsho. 2005;63 Suppl 7:596-8 pubmed
  3. Weinstock Guttman B, Bakshi R. Combination therapy for multiple sclerosis: the treatment strategy of the future?. CNS Drugs. 2004;18:777-92 pubmed
    ..Ultimately, the optimal therapies will likely include strategies that promote repair and limit tissue destruction in combination with anti-inflammatory interventions...
  4. Young E, Sieve A, Vichaya E, Carcoba L, Young C, Ambrus A, et al. Chronic restraint stress during early Theiler's virus infection exacerbates the subsequent demyelinating disease in SJL mice: II. CNS disease severity. J Neuroimmunol. 2010;220:79-89 pubmed publisher
    ..These findings indicate that RS during early TMEV infection increases CNS lesion formation during the late phase and suggest that the effects of RS are sex-dependent...
  5. Brinar V, Petelin Z, Brinar M, Djakovic V, Zadro I, Vranjes D. CNS demyelination in autoimmune diseases. Clin Neurol Neurosurg. 2006;108:318-26 pubmed
    ..We have reviewed 15 patients with autoimmune diseases and CNS demyelination in order to determine the nature of the demyelinating process...
  6. von Büdingen H, Gulati M, Kuenzle S, Fischer K, Rupprecht T, Goebels N. Clonally expanded plasma cells in the cerebrospinal fluid of patients with central nervous system autoimmune demyelination produce "oligoclonal bands". J Neuroimmunol. 2010;218:134-9 pubmed publisher
    ..We expand these findings by applying anti-idiotypic antibodies to detect specific heavy chain CDR3 idiotopes of cePC-produced antibodies amongst OCB in the CSF of a patient each with MS and acute disseminated encephalomyelitis...
  7. Selter R, Brilot F, Grummel V, Kraus V, Cepok S, Dale R, et al. Antibody responses to EBV and native MOG in pediatric inflammatory demyelinating CNS diseases. Neurology. 2010;74:1711-5 pubmed publisher
    ..The relation between antibody responses to EBV and nMOG has not been addressed in children so far...
  8. McMahon E, Cook D, Suzuki K, Matsushima G. Absence of macrophage-inflammatory protein-1alpha delays central nervous system demyelination in the presence of an intact blood-brain barrier. J Immunol. 2001;167:2964-71 pubmed
    ..Nonetheless, despite this possible compensation, our studies show the importance of MIP-1alpha in demyelination in the CNS and highlight its effect, particularly on cellular recruitment and cytokine regulation...
  9. Rossi D, Franceschetti S, Cerri M, Conconi A, Lunghi M, Capello D, et al. Hairy cell leukaemia complicated by anti-MAG paraproteinemic demyelinating neuropathy: resolution of neurological syndrome after cladribrine treatment. Leuk Res. 2007;31:873-6 pubmed
    ..Purine analogs may represent a choice in IgM PDN associated with lymphoproliferative disorders...

More Information

Publications62

  1. Ercolini A, Ludovic Croxford J, DeGutes M, Miller S. Cross-reactivity between peptide mimics of the immunodominant myelin proteolipid protein epitope PLP139-151: comparison of peptide priming in CFA vs. viral delivery. J Neuroimmunol. 2007;186:5-18 pubmed
    ..The pattern of in vitro reactivity and ability to induce CNS disease differs between peptide priming and virus infection...
  2. Gran B, Zhang G, Yu S, Li J, Chen X, Ventura E, et al. IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J Immunol. 2002;169:7104-10 pubmed
    ..These data demonstrate a redundancy of the IL-12 system in the induction of EAE and suggest that p40-related heterodimers, such as the recently cloned IL-23 (p40p19), may play an important role in disease pathogenesis...
  3. Hu W, Nessler S, Hemmer B, Eagar T, Kane L, Leliveld S, et al. Pharmacological prion protein silencing accelerates central nervous system autoimmune disease via T cell receptor signalling. Brain. 2010;133:375-88 pubmed publisher
    ..Our data identify cellular prion protein as a regulator of cellular immunological homoeostasis and suggest cellular prion protein as a novel potential target for therapeutic immunomodulation...
  4. Bressler B. Another tool in the epidemiologist's toolbox. Inflamm Bowel Dis. 2006;12:245-6 pubmed
  5. Vallat J, Magy L, Keita M. [Inflammation and demyelinization: IgIV mode of action]. Rev Neurol (Paris). 2006;162 Spec No 1:3S12-3S16 pubmed
    ..Interestingly the typical IgM immunoglobulins seemed more active than typical IgG ones. This observation may prompt new therapeutic options...
  6. Storch M, Bauer J, Linington C, Olsson T, Weissert R, Lassmann H. Cortical demyelination can be modeled in specific rat models of autoimmune encephalomyelitis and is major histocompatibility complex (MHC) haplotype-related. J Neuropathol Exp Neurol. 2006;65:1137-42 pubmed
    ..The mechanisms for this influence and any similar effects in humans will be important to define...
  7. Fischer D, Reimann J, Schroder R, Schmidt S. [Multifocal motor neuropathy: diagnosis and differential diagnosis]. Nervenarzt. 2002;73:1153-9 pubmed
    ..We present a patient with MMN and review the clinical, electrophysiological, and histological features. In addition,pathogenesis, differential diagnosis and treatment of MMN are discussed...
  8. Kamel M, Kelleher M, O Riordan C, Keohane C, O SULLIVAN M. CT and MRI 'ring sign' may be due to demyelination: diagnostic pitfall. Br J Neurosurg. 2007;21:309-11 pubmed
    ..We report a case of acute demyelinating encephalomyelitis (ADEM) in which both CT and MRI showed multiple ring-enhancing lesions suggestive of abscesses or brain tumour. This is a relatively rare phenomenon...
  9. Keegan M, Pineda A, McClelland R, Darby C, Rodriguez M, Weinshenker B. Plasma exchange for severe attacks of CNS demyelination: predictors of response. Neurology. 2002;58:143-6 pubmed
    ..021), preserved reflexes (p = 0.019), and early initiation of treatment (p = 0.009) were associated with moderate or marked improvement. Successfully treated patients improved rapidly following PE, and improvement was sustained...
  10. Kim B, Lyman M, Kang B, Kang H, Lee H, Mohindru M, et al. Pathogenesis of virus-induced immune-mediated demyelination. Immunol Res. 2001;24:121-30 pubmed
    ..Coupled with the initial inflammatory responses, viral persistence in the CNS may be a critical factor for sustaining inflammatory responses and consequent immune-mediated demyelinating disease...
  11. Sibai M, El Moutawakil B, Chourkani N, Bourezgui M, Rafai M, Slassi I. [Neurological manifestations of chronic inflammatory bowel disease]. Rev Neurol (Paris). 2008;164:859-65 pubmed publisher
    ..Several extra-intestinal manifestations of inflammatory bowel disease have been reported, although reports of neurologic disorders are rare...
  12. Fadil H, Kelley R, Gonzalez Toledo E. Differential diagnosis of multiple sclerosis. Int Rev Neurobiol. 2007;79:393-422 pubmed
  13. Bien C, Urbach H, Schramm J, Soeder B, Becker A, Voltz R, et al. Limbic encephalitis as a precipitating event in adult-onset temporal lobe epilepsy. Neurology. 2007;69:1236-44 pubmed
    ..There have been few studies of adult-onset disease. We recognized that some adult individuals have evidence of limbic encephalitis (LE), an autoimmune condition of adult life, which we proposed might lead directly to this syndrome...
  14. Dalmau J, Bataller L. [Limbic encephalitis: the new cell membrane antigens and a proposal of clinical-immunological classification with therapeutic implications]. Neurologia. 2007;22:526-37 pubmed
    ..In practice this selection excludes a significant number of patients with autoimmune encephalitides, some of which may represent new disorders...
  15. Magaña S, Pittock S, Lennon V, Keegan B, Weinshenker B, Lucchinetti C. Neuromyelitis optica IgG serostatus in fulminant central nervous system inflammatory demyelinating disease. Arch Neurol. 2009;66:964-6 pubmed publisher
    ..To our knowledge, this study is the first to compare NMO IgG serostatus among patients with fulminant central nervous system inflammatory demyelinating disease (CNS IDD)...
  16. Kimura A, Sakurai T, Koumura A, Yamada M, Hayashi Y, Tanaka Y, et al. High prevalence of autoantibodies against phosphoglycerate mutase 1 in patients with autoimmune central nervous system diseases. J Neuroimmunol. 2010;219:105-8 pubmed publisher
    ..Results of our study suggest that the anti-PGAM1 antibody is not only a marker of AIH but also a nonspecific marker of central nervous system autoimmune diseases...
  17. Marignier R, Chenevier F, Rogemond V, Sillevis Smitt P, Renoux C, Cavillon G, et al. Metabotropic glutamate receptor type 1 autoantibody-associated cerebellitis: a primary autoimmune disease?. Arch Neurol. 2010;67:627-30 pubmed publisher
  18. LaFerla F, Sugarman M, Lane T, Leissring M. Regional hypomyelination and dysplasia in transgenic mice with astrocyte-directed expression of interferon-gamma. J Mol Neurosci. 2000;15:45-59 pubmed
  19. Rus H, Cudrici C, Niculescu F. C5b-9 complement complex in autoimmune demyelination and multiple sclerosis: dual role in neuroinflammation and neuroprotection. Ann Med. 2005;37:97-104 pubmed
    ..These findings indicate that activation of complement C5b-9 plays a pro-inflammatory role in the acute phase of the disease, but may also be neuroprotective during the chronic phase of the disease...
  20. Olson J, Ludovic Croxford J, Miller S. Innate and adaptive immune requirements for induction of autoimmune demyelinating disease by molecular mimicry. Mol Immunol. 2004;40:1103-8 pubmed
  21. Pender M. Treating autoimmune demyelination by augmenting lymphocyte apoptosis in the central nervous system. J Neuroimmunol. 2007;191:26-38 pubmed
    ..In the case of T cells, apoptosis can be augmented by enhancing activation-induced T-cell apoptosis through the CD95 (Fas) pathway and by inhibiting costimulation-induced anti-apoptotic pathways mediated through BCL-2 and BCL-X L...
  22. Aloisi F, Serafini B, Adorini L. Glia-T cell dialogue. J Neuroimmunol. 2000;107:111-7 pubmed
  23. Meca Lallana J, Rodríguez Hilario H, Martínez Vidal S, Saura Luján I, Carretón Ballester A, Escribano Soriano J, et al. [Plasmapheresis: its use in multiple sclerosis and other demyelinating processes of the central nervous system. An observation study]. Rev Neurol. 2003;37:917-26 pubmed
  24. Bannerman P, Hahn A, Ramirez S, Morley M, Bonnemann C, Yu S, et al. Motor neuron pathology in experimental autoimmune encephalomyelitis: studies in THY1-YFP transgenic mice. Brain. 2005;128:1877-86 pubmed
    ..We hypothesize that these motor neuron abnormalities contribute to weakness in this form of EAE and speculate that similar motor neuron abnormalities are present in patients with progressive multiple sclerosis...
  25. Theodoridou A, Settas L. Demyelination in rheumatic diseases. J Neurol Neurosurg Psychiatry. 2006;77:290-5 pubmed
    ..Indeed, the clinical presentation and lesions evidenced by magnetic resonance imaging may be similar...
  26. Bellesi M, Logullo F, di Bella P, Provinciali L. CNS demyelination during anti-tumor necrosis factor alpha therapy. J Neurol. 2006;253:668-9 pubmed
  27. Codarri L, Fontana A, Becher B. Cytokine networks in multiple sclerosis: lost in translation. Curr Opin Neurol. 2010;23:205-11 pubmed publisher
  28. Bieber A, Warrington A, Asakura K, Ciric B, Kaveri S, Pease L, et al. Human antibodies accelerate the rate of remyelination following lysolecithin-induced demyelination in mice. Glia. 2002;37:241-9 pubmed
    ..We propose the use of human polyclonal IgM or specific human monoclonal IgM antibodies as potential therapies to enhance myelin repair following CNS injury and disease...
  29. Rotshenker S. Microglia and macrophage activation and the regulation of complement-receptor-3 (CR3/MAC-1)-mediated myelin phagocytosis in injury and disease. J Mol Neurosci. 2003;21:65-72 pubmed
    ..Monoclonal antibody-induced phagocytosis regulation must reveal a mechanism by which native extracellular molecules bind to and regulate CR3/MAC-1-mediated myelin phagocytosis in microglia and macrophages...
  30. Scheid R, Teich N. Neurologic manifestations of ulcerative colitis. Eur J Neurol. 2007;14:483-93 pubmed
    ..A prospective study on the neurologic aspects of UC would be very welcome...
  31. Briggs D, Martin C, Ingersoll S, Barnum S, Martin B. Astrocyte-specific expression of a soluble form of the murine complement control protein Crry confers demyelination protection in the cuprizone model. Glia. 2007;55:1405-15 pubmed
    ..These data suggest that temporal restriction of complement inhibition may be required in some disease settings...
  32. Chekhonin V, Semenova A, Gurina O, Dmitrieva T. [Myelin oligodendrogliocyte glycoprotein: the structure, functions, role in pathogenesis of demyelinating disorders]. Biomed Khim. 2003;49:411-23 pubmed
    ..The structure, membrane topology, putative functions and role in demyelinating diseases are considered in this review...
  33. Noseworthy J, O Brien P, Petterson T, Weis J, Stevens L, Peterson W, et al. A randomized trial of intravenous immunoglobulin in inflammatory demyelinating optic neuritis. Neurology. 2001;56:1514-22 pubmed
    ..To determine whether IV immunoglobulin (IVIg) reverses chronic visual impairment in MS patients with optic neuritis (ON)...
  34. Hisahara S, Okano H, Miura M. Caspase-mediated oligodendrocyte cell death in the pathogenesis of autoimmune demyelination. Neurosci Res. 2003;46:387-97 pubmed
    ..Therefore, caspase-mediated OLG death leads to the exacerbation of demyelination and the deterioration of neurological manifestations by inducing local inflammatory events...
  35. Onuki M, Ayers M, Bernard C, Orian J. Axonal degeneration is an early pathological feature in autoimmune-mediated demyelination in mice. Microsc Res Tech. 2001;52:731-9 pubmed
    ..These data establish that in the model of MS-like disease, the peak of clinical episodes coincides with severe inflammation and demyelination and that axonal pathology correlates with clinical progression...
  36. Scarisbrick I, Blaber S, Tingling J, Rodriguez M, Blaber M, Christophi G. Potential scope of action of tissue kallikreins in CNS immune-mediated disease. J Neuroimmunol. 2006;178:167-76 pubmed
    ..The patterns of co-expression and co-regulation described point to novel effector roles for select tissue kallikreins in neurological disorders involving T cells, such as multiple sclerosis...
  37. Hu W, Lucchinetti C. The pathological spectrum of CNS inflammatory demyelinating diseases. Semin Immunopathol. 2009;31:439-53 pubmed publisher
    ..Herein, we review the clinicopathologic features of these CNS inflammatory demyelinating disorders and discuss recent advances in understanding their immunopathogenesis...
  38. Ousman S, David S. MIP-1alpha, MCP-1, GM-CSF, and TNF-alpha control the immune cell response that mediates rapid phagocytosis of myelin from the adult mouse spinal cord. J Neurosci. 2001;21:4649-56 pubmed
    ..These findings will have important implications for CNS regeneration and demyelinating disease...
  39. Mares Segura R. [Spinal cord paraneoplastic syndromes]. Rev Neurol. 2000;31:1219-23 pubmed
    ..We reviewed the bibliography of various paraneoplastic syndromes which may show spinal involvement...
  40. Gottfried J, Finkel T, Hunter J, Carpentieri D, Finkel R. Central nervous system Sjögren's syndrome in a child: case report and review of the literature. J Child Neurol. 2001;16:683-5 pubmed
    ..This report reviews the pediatric literature and underscores the importance of considering Sjögren's syndrome in a child with unexplained facial weakness and in the differential diagnosis of pediatric stroke...
  41. Zhang G, Gran B, Yu S, Li J, Siglienti I, Chen X, et al. Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system. J Immunol. 2003;170:2153-60 pubmed
  42. Dalakas M. Inhibiting leukocyte recruitment to the brain by IVIg: is it relevant to the treatment of demyelinating CNS disorders?. Brain. 2004;127:2569-71 pubmed
  43. King I, Dickendesher T, Segal B. Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease. Blood. 2009;113:3190-7 pubmed publisher
  44. Harris M, Walsh L, Hattab E, Golomb M. Is it ADEM, POLG, or both?. Arch Neurol. 2010;67:493-6 pubmed publisher
    ..To describe a child with apparent brain biopsy-confirmed acute disseminated encephalomyelitis (ADEM) but genetic confirmation of compound heterozygosity for DNA mutations of the polymerase gamma (POLG) gene...
  45. Evseev V, Mikovskaia O. [Neuroimmunopathology: immunoaggression, dysregulation, adoptive immunotherapy prospects]. Zh Nevrol Psikhiatr Im S S Korsakova. 2002;102:60-4 pubmed
  46. Bartos A, Stourac P, Rusina R, Sejdová M, Velenska Z. [Paraneoplastic cerebellar degeneration associated with ovarian cancer: anti-Yo immunoreactivity in autoptic cerebellum and ovarian carcinoma]. Nervenarzt. 2002;73:995-8 pubmed
  47. Mikaeloff Y, Adamsbaum C, Husson B, Vallee L, Ponsot G, Confavreux C, et al. MRI prognostic factors for relapse after acute CNS inflammatory demyelination in childhood. Brain. 2004;127:1942-7 pubmed
    ..Their low sensitivity, however, shows that this prediction remains difficult...
  48. Dalmau J, Porta Etessam J. [Paraneoplastic cerebral syndromes with oto-neuro-ophthalomologic manifestations]. Rev Neurol. 2000;31:1213-9 pubmed
    ..To review the paraneoplastic neurologic syndromes associated with otoneurophthalmologic manifestations...
  49. Alberdi E, Sánchez Gómez M, Torre I, Domercq M, Perez Samartin A, Pérez Cerdá F, et al. Activation of kainate receptors sensitizes oligodendrocytes to complement attack. J Neurosci. 2006;26:3220-8 pubmed
    ..These findings indicate that glutamate sensitization of oligodendrocytes to complement attack may contribute to white matter damage in acute and chronic neurological disorders...
  50. Olson J, Miller S. The innate immune response affects the development of the autoimmune response in Theiler's virus-induced demyelinating disease. J Immunol. 2009;182:5712-22 pubmed publisher
    ..These results demonstrate that activating or enhancing the innate immune response can reduce the subsequent initiation and progression of the autoimmune response and demyelinating disease...
  51. Takanashi J, Tada H, Kuroki H, Barkovich A. Delirious behavior in influenza is associated with a reversible splenial lesion. Brain Dev. 2009;31:423-6 pubmed publisher
    ..A reversible splenial lesion with reduced diffusion should be considered as an underlying condition in patients with delirious behavior associated with influenza...
  52. Mestre T, Correia de Sá J, Pimentel J. Multifocal central and peripheral demyelination associated with hepatitis C virus infection. J Neurol. 2007;254:1754-6 pubmed
  53. Breithaupt C, Schäfer B, Pellkofer H, Huber R, Linington C, Jacob U. Demyelinating myelin oligodendrocyte glycoprotein-specific autoantibody response is focused on one dominant conformational epitope region in rodents. J Immunol. 2008;181:1255-63 pubmed
    ..Comparison of the structure of MOG(ex) with the structures of related IgV-like domains yields a possible explanation for the focused Ab response...