nervous system


Summary: The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)

Top Publications

  1. Pennati R, Dell Anna A, Zega G, De Bernardi F. Immunohistochemical study of the nervous system of the tunicate Thalia democratica (Forsskal, 1775). Eur J Histochem. 2012;56:e16 pubmed publisher
    ..Moreover, immunolabelling of the nervous system showed the presence of eight pairs of nerve fibres emerging from the neural ganglion...
  2. Rajan P. STATus and Context within the Mammalian Nervous System. Mol Med. 2011;17:965-73 pubmed publisher the context within which Stat3-mediated effects are elicited within the developing and adult mammalian nervous system. Stat3 signals are pivotal to the proliferation and differentiation of neural stem cells...
  3. Bookout A, de Groot M, Owen B, Lee S, Gautron L, Lawrence H, et al. FGF21 regulates metabolism and circadian behavior by acting on the nervous system. Nat Med. 2013;19:1147-52 pubmed publisher
    ..These findings demonstrate a crucial role for the nervous system in mediating the diverse physiologic and pharmacologic actions of FGF21.
  4. Doitsidou M, Flames N, Topalidou I, Abe N, Felton T, Remesal L, et al. A combinatorial regulatory signature controls terminal differentiation of the dopaminergic nervous system in C. elegans. Genes Dev. 2013;27:1391-405 pubmed publisher
    Terminal differentiation programs in the nervous system are encoded by cis-regulatory elements that control the expression of terminal features of individual neuron types...
  5. Baas P, Ahmad F. Beyond taxol: microtubule-based treatment of disease and injury of the nervous system. Brain. 2013;136:2937-51 pubmed publisher
    ..neuroscientists have earmarked microtubules as a promising target for therapy of injury and disease of the nervous system. Proof-of-principle has come mainly from studies using taxol and related drugs to pharmacologically stabilize ..
  6. Lang M, Fan Q, Wang L, Zheng Y, Xiao G, Wang X, et al. Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates A?42-induced Alzheimer's disease-like symptoms. Neurobiol Aging. 2013;34:2604-12 pubmed publisher
    ..were obtained from inhibiting another copper importer Ctr1B and overexpressing a copper exporter DmATP7 in the nervous system of AD flies...
  7. Tissir F, Goffinet A. Shaping the nervous system: role of the core planar cell polarity genes. Nat Rev Neurosci. 2013;14:525-35 pubmed publisher
    ..In particular, core PCP genes are crucial for the development and function of the nervous system. They are involved in neural tube closure, ependymal polarity, neuronal migration, dendritic growth and axon ..
  8. Sims Robinson C, Hur J, Hayes J, Dauch J, Keller P, Brooks S, et al. The role of oxidative stress in nervous system aging. PLoS ONE. 2013;8:e68011 pubmed publisher
    While oxidative stress is implicated in aging, the impact of oxidative stress on aging in the peripheral nervous system is not well understood...
  9. Franze K. The mechanical control of nervous system development. Development. 2013;140:3069-77 pubmed publisher
    The development of the nervous system has so far, to a large extent, been considered in the context of biochemistry, molecular biology and genetics...

More Information


  1. Hegarty S, O Keeffe G, Sullivan A. BMP-Smad 1/5/8 signalling in the development of the nervous system. Prog Neurobiol. 2013;109:28-41 pubmed publisher
    ..BMPs and their receptors are expressed in the nervous system (NS) throughout its development. This review focuses on the actions of Smad 1/5/8 in the developing NS...
  2. Estacio Gómez A, Moris Sanz M, Schäfer A, Perea D, Herrero P, Diaz Benjumea F. Bithorax-complex genes sculpt the pattern of leucokinergic neurons in the Drosophila central nervous system. Development. 2013;140:2139-48 pubmed publisher
    ..complex (Bx-C) of Drosophila act to define segmental differences in the ventral nerve cord of the central nervous system. To achieve this, we have focused on the specification of the leucokinin-expressing neurons...
  3. Cooper J. Cell biology in neuroscience: mechanisms of cell migration in the nervous system. J Cell Biol. 2013;202:725-34 pubmed publisher
    ..New research is needed to fully understand how migration of such morphologically complicated cells is coordinated over space and time. ..
  4. Liu J, Zhang B, Lei H, Feng Z, Liu J, Hsu A, et al. Functional aging in the nervous system contributes to age-dependent motor activity decline in C. elegans. Cell Metab. 2013;18:392-402 pubmed publisher
    ..Here we approach this question in C. elegans by functionally characterizing its aging nervous system and muscles. We find that motor neurons exhibit a progressive functional decline, beginning in early life...
  5. Tu T, Gao Q, Luo Y, Chen J, Lu D, Feng J, et al. CD146 deletion in the nervous system impairs appetite, locomotor activity and spatial learning in mice. PLoS ONE. 2013;8:e74124 pubmed publisher
    Cell adhesion molecules (CAMs) are crucial effectors for the development and maintenance of the nervous system. Mutations in human CAM genes are linked to brain disorders and psychological diseases, and CAM knockout mice always exhibit ..
  6. Sultan F, Sweatt J. The role of the Gadd45 family in the nervous system: a focus on neurodevelopment, neuronal injury, and cognitive neuroepigenetics. Adv Exp Med Biol. 2013;793:81-119 pubmed publisher
    ..and interleukin-induced transcription and have since been implicated in a host of normal and aberrant central nervous system processes...
  7. McKinnon P. Maintaining genome stability in the nervous system. Nat Neurosci. 2013;16:1523-9 pubmed publisher
    Active maintenance of genome stability is a prerequisite for the development and function of the nervous system. The high replication index during neurogenesis and the long life of mature neurons highlight the need for efficient cellular ..
  8. Kegel L, Aunin E, Meijer D, Bermingham J. LGI proteins in the nervous system. ASN Neuro. 2013;5:167-81 pubmed publisher
    The development and function of the vertebrate nervous system depend on specific interactions between different cell types. Two examples of such interactions are synaptic transmission and myelination...
  9. Nicosia V, Vértes P, Schafer W, Latora V, Bullmore E. Phase transition in the economically modeled growth of a cellular nervous system. Proc Natl Acad Sci U S A. 2013;110:7880-5 pubmed publisher
    ..Here, we study the cellular nervous system of the nematode worm Caenorhabditis elegans, together with information on the birth times of neurons and on ..
  10. Verslegers M, Lemmens K, Van Hove I, Moons L. Matrix metalloproteinase-2 and -9 as promising benefactors in development, plasticity and repair of the nervous system. Prog Neurobiol. 2013;105:60-78 pubmed publisher
    ..most prominently in the field of cancer metastasis, and more recent investigations also focus on the nervous system, with a striking emphasis on the gelatinases, MMP-2 and MMP-9...
  11. Staab T, Griffen T, Corcoran C, Evgrafov O, Knowles J, Sieburth D. The conserved SKN-1/Nrf2 stress response pathway regulates synaptic function in Caenorhabditis elegans. PLoS Genet. 2013;9:e1003354 pubmed publisher
    ..These results provide insight into how SKN-1/Nrf2 might protect the nervous system from damage in response to oxidative stress.
  12. Mayer G, Kauschke S, Rüdiger J, Stevenson P. Neural markers reveal a one-segmented head in tardigrades (water bears). PLoS ONE. 2013;8:e59090 pubmed publisher
    ..A comparison of the nervous system innervating the foregut and midgut structures in tardigrades and onychophorans to that of arthropods indicates ..
  13. Papadopoulos M, Verkman A. Aquaporin water channels in the nervous system. Nat Rev Neurosci. 2013;14:265-77 pubmed publisher
  14. Kramer T, Enquist L. Directional spread of alphaherpesviruses in the nervous system. Viruses. 2013;5:678-707 pubmed publisher
    ..Directional spread of infection in the nervous system is a key component of the viral lifecycle and is critical for the onset of alphaherpesvirus-related diseases...
  15. Valent F, Horvat M, Sofianou Katsoulis A, Spirić Z, Mazej D, Little D, et al. Neurodevelopmental effects of low-level prenatal mercury exposure from maternal fish consumption in a Mediterranean cohort: study rationale and design. J Epidemiol. 2013;23:146-52 pubmed
    ..Finally, this is a multinational study and thus permits assessment of the relation between mercury and child neurodevelopment in different populations. ..
  16. Maiese K, Chong Z, Shang Y, Wang S. mTOR: on target for novel therapeutic strategies in the nervous system. Trends Mol Med. 2013;19:51-60 pubmed publisher
    ..Targeting mTOR in the nervous system can offer exciting new avenues of drug discovery, but crucial to this premise is elucidating the complexity of ..
  17. Ye H, Hui L, Kellersberger K, Li L. Mapping of neuropeptides in the crustacean stomatogastric nervous system by imaging mass spectrometry. J Am Soc Mass Spectrom. 2013;24:134-47 pubmed publisher
    Considerable effort has been devoted to characterizing the crustacean stomatogastric nervous system (STNS) with great emphasis on comprehensive analysis and mapping distribution of its diverse neuropeptide complement...
  18. García Huerta P, Diaz Hernandez M, Delicado E, Pimentel Santillana M, Miras Portugal M, Gomez Villafuertes R. The specificity protein factor Sp1 mediates transcriptional regulation of P2X7 receptors in the nervous system. J Biol Chem. 2012;287:44628-44 pubmed publisher
    ..the brain, demonstrating that Sp1 is a key element in the transcriptional regulation of P2X7 receptor in the nervous system. Finally, we found that Sp1 mediates P2X7 receptor up-regulation in neuroblastoma cells cultured in the ..
  19. Jenett A, Rubin G, Ngo T, Shepherd D, Murphy C, Dionne H, et al. A GAL4-driver line resource for Drosophila neurobiology. Cell Rep. 2012;2:991-1001 pubmed publisher
    ..The GAL4 lines allow expression of exogenous genes in distinct, small subsets of the adult nervous system. The set of DNA fragments, each driving a documented expression pattern, will facilitate the generation of ..
  20. Thomas C, Paquola A, Muotri A. LINE-1 retrotransposition in the nervous system. Annu Rev Cell Dev Biol. 2012;28:555-73 pubmed publisher
    ..In this review, we survey the literature related to neurodevelopmental retrotransposition and discuss possible relevance to neuronal function, evolution, and neurological disease. ..
  21. Hilgers V, Lemke S, Levine M. ELAV mediates 3' UTR extension in the Drosophila nervous system. Genes Dev. 2012;26:2259-64 pubmed publisher
    Post-transcriptional gene regulation is prevalent in the nervous system, where multiple tiers of regulatory complexity contribute to the development and function of highly specialized cell types...
  22. Jensen M, Hoerndli F, Brockie P, Wang R, Johnson E, Maxfield D, et al. Wnt signaling regulates acetylcholine receptor translocation and synaptic plasticity in the adult nervous system. Cell. 2012;149:173-87 pubmed publisher
    The adult nervous system is plastic, allowing us to learn, remember, and forget. Experience-dependent plasticity occurs at synapses--the specialized points of contact between neurons where signaling occurs...