spontaneous neoplasm regression


Summary: Disappearance of a neoplasm or neoplastic state without the intervention of therapy.

Top Publications

  1. Bir A, Fora A, LeVea C, Fakih M. Spontaneous regression of colorectal cancer metastatic to retroperitoneal lymph nodes. Anticancer Res. 2009;29:465-8 pubmed
    ..The identification and characterization of similar cases would probably result in defining a patient population that can be followed by observation and may result in the development of novel therapeutic strategies. ..
  2. Binder R, Johnson G, Gallagher P, Stockman S, Sundberg J, Conti C. Squamous cell hyperplastic foci: precursors of cutaneous papillomas induced in SENCAR mice by a two-stage carcinogenesis regimen. Cancer Res. 1998;58:4314-23 pubmed
    ..SCHF may also have utility as early indicators of potential skin tumorigenicity in cancer bioassays...
  3. Robinson B, Robinson C, Lake R. Localised spontaneous regression in mesothelioma -- possible immunological mechanism. Lung Cancer. 2001;32:197-201 pubmed
    ..The patient survived for 20 months and, in contrast to her initial biopsy, no significant lymphoid infiltrate was detected in her MM tissue at post mortem examination...
  4. Gunther E, Moody S, Belka G, Hahn K, Innocent N, Dugan K, et al. Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis. Genes Dev. 2003;17:488-501 pubmed
  5. Cui Z, Willingham M, Hicks A, Alexander Miller M, Howard T, Hawkins G, et al. Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in mice. Proc Natl Acad Sci U S A. 2003;100:6682-7 pubmed
    ..The mice are healthy and cancer-free and have a normal life span. These observations suggest a previously unrecognized mechanism of immune surveillance, which may have potential for therapy or prevention of cancer...
  6. Horii R, Akiyama F, Kasumi F, Koike M, Sakamoto G. Spontaneous " healing" of breast cancer. Breast Cancer. 2005;12:140-4 pubmed
    ..Healing is a phenomenon by which the intraductal component of breast cancer disappears and is replaced by fibrous tissue. Focally localized healing often prevents confirmation of the continuity of intraductal carcinoma...
  7. Challis G, Stam H. The spontaneous regression of cancer. A review of cases from 1900 to 1987. Acta Oncol. 1990;29:545-50 pubmed
    ..We conclude that the literature on the spontaneous regression of cancer is still unable to provide unambiguous accounts of the mechanisms operating to affect these regressions...
  8. Hu X, Feng F, Wang Y, Wang L, He F, Dou G, et al. Blockade of Notch signaling in tumor-bearing mice may lead to tumor regression, progression, or metastasis, depending on tumor cell types. Neoplasia. 2009;11:32-8 pubmed
  9. Wang L, Pitman M, Castillo C, Dal Cin P, Oliva E. Choriocarcinoma involving the pancreas as first manifestation of a metastatic regressing mixed testicular germ cell tumor. Mod Pathol. 2004;17:1573-80 pubmed
    ..Subsequent resection of the testicular mass confirmed the presence of a cystic and scarring (regressing) mixed germ cell tumor but without evidence of choriocarcinoma. ..

More Information

Publications109 found, 100 shown here

  1. Cakirer S, Karaarslan E. Spontaneous involution of a non-optic astrocytoma in neurofibromatosis type I: serial magnetic resonance imaging evaluation. Acta Radiol. 2004;45:669-73 pubmed
  2. Bradbury J. High-grade cervical dysplasias: to regress or not to regress?. Lancet Oncol. 2005;6:545 pubmed
  3. Akyuz M, Goksu E, Tuncer R. Spontaneous decrease in the size of a residual thoracic intradural lipoma. Br J Neurosurg. 2005;19:53-5 pubmed
    ..An 18-year-old male patient, with a thoracic intradural lipoma showing spontaneous decrease in the size of a residual lipoma and tethering of the cord 4 years after surgery, is presented in this report. ..
  4. Kappauf H. [God does not let himself be instrumented (interview by Dr. Peter Stiefelhagen)]. MMW Fortschr Med. 2005;147:8 pubmed
  5. Smith S, Buckingham E, Williams E. Management of cutaneous juvenile hemangiomas. Facial Plast Surg. 2008;24:50-64 pubmed publisher
    ..Special emphasis will be given to surgical technique and several cases of late involuting hemangiomas of the face will be presented. ..
  6. Hiyama E, Hiyama K, Yamaoka H, Sueda T, Reynolds C, Yokoyama T. Expression profiling of favorable and unfavorable neuroblastomas. Pediatr Surg Int. 2004;20:33-8 pubmed
  7. Kubo H, Matsushita S, Fukushige T, Kanzaki T, Kanekura T. Spontaneous regression of recurrent and metastatic Merkel cell carcinoma. J Dermatol. 2007;34:773-7 pubmed
    ..Although she received no treatment due to her poor condition, the recurrent metastatic lesion regressed spontaneously within 2 months. ..
  8. Crisci A, Corsale I, Abrami F, Politi L, Andreani M, Borgianni S, et al. [Spontaneous regression of lung metastases from renal cell carcinoma: the importance of immunogenetic factors and a review of the literature]. Minerva Urol Nefrol. 2008;60:123-35 pubmed
    ..Vaccine therapy for RCC is no longer far out of reach. The characteristics of RCC make it a fertile field for the study of prometastatic and endogenous antiangiogenic factors. ..
  9. Burgert S, Jones D. Recurring digital fibroma of childhood. J Hand Surg Br. 1996;21:400-2 pubmed
    ..Surgeons should be aware of the clinical features and the principles of management of this condition, as patients may be referred because of associated finger or toe deformities. ..
  10. Hu J, Peng X, Cladel N, Pickel M, Christensen N. Large cutaneous rabbit papillomas that persist during cyclosporin A treatment can regress spontaneously after cessation of immunosuppression. J Gen Virol. 2005;86:55-63 pubmed
    ..However, returning immunity can lead to regression and clearance of large papillomas (with increased antigenicity) in an outbred population, whilst these same antigenic papillomas persist in inbred rabbits...
  11. Futagami A, Aoki M, Kawana S. A case of peripheral T-cell lymphoma unspecified involving subcutaneous tissue. Leuk Lymphoma. 2005;46:785-8 pubmed
    ..A genetic analysis demonstrated a rearrangement of the T-cell receptor chain gene. The left skin lesion also gradually disappeared after skin biopsy without therapy, and he continues to be in remission. ..
  12. Dauphin C, Motreff P, Ruivard M, Rieu V, Cloix J, Lamaison D, et al. Regressive aortic valve and infundibular tumors during idiopathic hypereosinophilic syndrome. J Am Soc Echocardiogr. 2005;18:e8 pubmed
    ..The patient suddenly died of septic shock 16 months after first being seen. ..
  13. Zahl P, Maehlen J. Model of outcomes of screening mammography: spontaneous regression of breast cancer may not be uncommon. BMJ. 2005;331:350; author reply 351 pubmed
  14. Del Poggio P, Mattiello M, Gilardoni L, Jamoletti C, Colombo S, Zabbialini G. The mysterious case of spontaneous disappearance of hepatocellular carcinoma. Dig Liver Dis. 2009;41:e21-5 pubmed publisher
    ..The spontaneous and durable regression of the HCC and the persistent peripheral enhancing rim could be explained by a strong and persistent activation of the immune system directed against the neoplastic cells. ..
  15. Socrier Y, Lauwers Cances V, Lamant L, Garrido I, Lauwers F, Lopez R, et al. Histological regression in primary melanoma: not a predictor of sentinel lymph node metastasis in a cohort of 397 patients. Br J Dermatol. 2010;162:830-4 pubmed publisher
    ..006) and >or= 2.0 mm (adjusted OR 3.5; 95% CI 1.7-7.4; P = 0.001) and ulceration of the melanoma (adjusted OR 1.8; 95% CI 1.1-3.2; P = 0.03). Regression is not an independent predictor of the risk of SLN metastasis in melanoma. ..
  16. Guntheroth W, Fujioka M, Reichenbach D. Spontaneous resolution of obstructive valvular tumors in infants. Am Heart J. 2002;143:868-72 pubmed
    ..An alternate diagnosis for these 4 cases could be a tissue "myxomatous rest" as opposed to a neoplastic myxoma. In either case, surgical intervention may not be necessary. ..
  17. Brix M, Soupre V, Enjolras O, Vazquez M. [Antenatal diagnosis of rapidly involuting congenital hemangiomas (RICH)]. Rev Stomatol Chir Maxillofac. 2007;108:109-14 pubmed
    ..Regular follow-up is necessary during the first months to confirm the diagnosis. RICH regress rapidly while the size of malignant tumors increases. A biopsy is necessary to obtain histopatholgical proof. ..
  18. Watanabe N, Seno H, Nakajima T, Yazumi S, Miyamoto S, Matsumoto S, et al. Regression of fundic gland polyps following acquisition of Helicobacter pylori. Gut. 2002;51:742-5 pubmed
    ..Interestingly, in the remaining polyp, we found an activating beta-catenin gene mutation whereas no such mutations were detected in FGPs of patient No II. Thus H pylori infection may have an inhibitory effect on the development of FGPs. ..
  19. Ginsberg G. Endoluminal therapy for Barrett's with high-grade dysplasia and early esophageal adenocarcinoma. Clin Gastroenterol Hepatol. 2003;1:241-5 pubmed
  20. Baamonde A, Lastra A, Fresno M, Llames S, Meana A, Hidalgo A, et al. Implantation of tumoral XC cells induces chronic, endothelin-dependent, thermal hyperalgesia in mice. Cell Mol Neurobiol. 2004;24:269-81 pubmed
    ..5. It might be concluded that endothelins are probably involved in this type of long-term thermal hyperalgesia produced by the transitory presence of the XC tumoral cell line. ..
  21. Atik E. Late spontaneous regression of obstructive tumor in the mitral valve. Arq Bras Cardiol. 2009;93:e60-2, e48-50 pubmed
  22. Sioud M. How does autoimmunity cause tumor regression? A potential mechanism involving cross-reaction through epitope mimicry. Mol Med. 2002;8:115-9 pubmed
    ..This strategy may down the friendly established relationship between tumor tissues and the cells of the immune system. ..
  23. Adam J. Mathematical models of prevascular spheroid development and catastrophe-theoretic description of rapid metastatic growth/tumor remission. Invasion Metastasis. 1996;16:247-67 pubmed
  24. Jinnai K, Hayashi Y. Hemorrhage in the oculomotor nerve as a complication of leukemia. Neuropathology. 2001;21:241-4 pubmed
    ..Although hemorrhagic oculomotor paralysis is a very rare complication, reports of its occurrence will likely increase with improved survival times of leukemia patients due to advances in chemotherapy. ..
  25. Bissen L, Brasseur P, Sukkarieh F. [Spontaneous regression of testicular tumor]. JBR-BTR. 2003;86:319-21 pubmed
    ..Testicular ultrasonography is today the gold-standard technique and any parenchymal echostructure abnormality should be verified histologically. ..
  26. Peña Avila M, Cogolludo Pérez F, Silva Grosso M, Santos Corchero J, Téllez Molina M, Martín Rodilla M, et al. [Report of a case: non-Hodgkin's lymphoma of the hypopharynx in a patient with HIV infection. Remission without lymphoma-specific treatment]. Acta Otorrinolaringol Esp. 2003;54:597-600 pubmed
    ..Simultaneously he was diagnosed as HIV. The interest of this paper is the total remission of the lymphoma seen after specific HIV treatment only. ..
  27. Bacci G, Palmerini E, Staals E, Ferrari S, Battaglia M, Longhi A, et al. Spontaneous regression of lung metastasis from osteosarcoma: a case report. J Pediatr Hematol Oncol. 2008;30:90-2 pubmed publisher
    ..The patient was followed up every 3 months and a spontaneous regression of the lesion was documented. Seven years after the diagnosis of lung metastases, no pulmonary nodules or other signs of relapse are present...
  28. Inaba H, Kawasaki H, Nakamura S, Yamamoto H, Kaneko Y, Satake N, et al. Anaplastic large cell lymphoma associated with Sjögren's syndrome. Leuk Lymphoma. 1998;32:183-8 pubmed
    ..To the best of our knowledge, this is the first reported case of ALCL presenting concurrently with SjS. ..
  29. Maruo K, Kayashima K, Ono T. Regressing Merkel cell carcinoma-a case showing replacement of tumour cells by foamy cells. Br J Dermatol. 2000;142:1184-9 pubmed
    ..Histopathological analysis of the completely regressed tumour revealed that the tumour cells were completely replaced by numerous foamy cells. This is the first report demonstrating the histopathological features of regressing MCC. ..
  30. Ueno S, Yokoyama S, Hirakawa H, Yabe H, Suzuki Y, Atsumi H, et al. Use of real-time magnetic resonance guidance to assist bone biopsy in pediatric malignancy. Pediatrics. 2002;109:E18 pubmed
    ..MR-guided biopsy technique is likely to be particularly useful for the resection of invisible metastatic lesions, especially those that are only visible using MRI. ..
  31. Iijima H, Moriwaki Y, Yamamoto T, Takahashi S, Nishigami T, Hada T. Spontaneous regression of hepatic adenoma in a patient with glycogen storage disease type I after hemodialysis: ultrasonographic and CT findings. Intern Med. 2001;40:891-5 pubmed
    ..During follow-up, the present patient received hemodialysis due to renal failure, and the adenoma regressed spontaneously after 8 years. Included are diagnostic images, demonstrating the association of hepatic adenoma and GSD-type I. ..
  32. Dehner L. Pediatric adrenocortical neoplasms: on the road to some clarity. Am J Surg Pathol. 2003;27:1005-7 pubmed
  33. Ackermann S, Gehrsitz C, Mehlhorn G, Beckmann M. Management and course of histologically verified cervical carcinoma in situ during pregnancy. Acta Obstet Gynecol Scand. 2006;85:1134-7 pubmed
    ..Colposcopic guided biopsy should rule out an invasive process during pregnancy. Cesarean section as the mode of delivery should be considered, if invasion is suspected. ..
  34. Simpson K, Albores Saavedra J. Unusual findings in papillary thyroid microcarcinoma suggesting partial regression: a study of two cases. Ann Diagn Pathol. 2007;11:97-102 pubmed
    ..Thus, we believe that these histologic changes suggest regression because papillary thyroid microcarcinomas measuring less than 1.5 mm do not metastasize and have been considered innocuous or medical curiosities. ..
  35. Abdelrazeq A, Lund J, Leveson S. Spontaneous regression of peritoneal carcinomatosis from a rectal cancer. Eur J Gastroenterol Hepatol. 2005;17:1421-3 pubmed
    ..A review of the literature revealed two cases of spontaneous regression of peritoneal carcinomatosis secondary to a rectal cancer; we report the third case and discuss some of the reasons potentially responsible for the regression. ..
  36. Janikova A, Bolcak K, Pavlik T, Mayer J, Kral Z. Value of [18F]fluorodeoxyglucose positron emission tomography in the management of follicular lymphoma: the end of a dilemma?. Clin Lymphoma Myeloma. 2008;8:287-93 pubmed publisher
    ..Persisting PET positivity after treatment predicts for a high risk of an early relapse and can identify patients with poor prognosis. ..
  37. Connelly T, Cribier B, Brown T, Yanguas I. Complete spontaneous regression of Merkel cell carcinoma: a review of the 10 reported cases. Dermatol Surg. 2000;26:853-6 pubmed
    ..The nature of regression in these 10 cases may point toward future immunologic therapy just as similar cases of CRS in patients with melanoma have led to advances in the immunologic treatment for that malignancy. ..
  38. Zalaudek I, Argenziano G, Ferrara G, Soyer H, Corona R, Sera F, et al. Clinically equivocal melanocytic skin lesions with features of regression: a dermoscopic-pathological study. Br J Dermatol. 2004;150:64-71 pubmed
    ..9%) and involving > 50% of the lesion surface (47.8%). Using degree and type of BWS, an algorithm was constructed that can be applied for the management of lesions exhibiting dermoscopic features of regression. ..
  39. Murphy M, Worth R, Norris J. 'Disappearing' recurrent craniopharyngioma. Br J Neurosurg. 2004;18:65 pubmed
  40. Ohtani H, Yamazaki O, Matsuyama M, Horii K, Shimizu S, Oka H, et al. Spontaneous regression of hepatocellular carcinoma: report of a case. Surg Today. 2005;35:1081-6 pubmed
    ..In our case, the vascularity of the tumor according to the imaging findings was followed up during the clinical course. The patient is now doing well and without any evidence of recurrence at 37 months after surgery. ..
  41. Gelabert Gonzalez M, Serramito García R, Garcia Allut A. [Spontaneous resolution of an asymptomatic intracranial arachnoid cyst]. Neurocirugia (Astur). 2008;19:361-4 pubmed
    ..We review the cases previously reported and the mechanisms underlying the resolution of the arachnoid cysts are discussed. ..
  42. Plautz G, Mukai S, Cohen P, Shu S. Cross-presentation of tumor antigens to effector T cells is sufficient to mediate effective immunotherapy of established intracranial tumors. J Immunol. 2000;165:3656-62 pubmed
  43. Oliveira Penido N, Tangerina R, Macoto Kosugi E, Cesário de Abreu C, Brandão Vasco M. Vestibular Schwannoma: spontaneous tumor involution. Braz J Otorhinolaryngol. 2007;73:867-871 pubmed publisher
    ..Moreover, in terms of postoperative sequelae, there is no difference between patients who underwent surgery immediately after diagnosis and those who underwent initial conservative treatment for these tumors. ..
  44. Miwa T, Yoshida K, Shidoh S, Kano T, Muto J, Kawase T. Spontaneous regression after standard transsphenoidal surgery in a huge pituitary adenoma with epidural extension. Neurol Med Chir (Tokyo). 2009;49:421-3 pubmed
    ..The reason for the spontaneous regression remains unclear. ..
  45. Kobayashi K, Sato T, Sunaoshi K, Takahashi A, Tamakawa M. Spontaneous regression of primary renal cell carcinoma with inferior vena caval tumor thrombus. J Urol. 2002;167:242-3 pubmed
  46. Balzer B, Ulbright T. Spontaneous regression of testicular germ cell tumors: an analysis of 42 cases. Am J Surg Pathol. 2006;30:858-65 pubmed
    ..In contrast, nonspecific atrophy lacks distinct scars, and scars from non-neoplastic causes lack most of the associated findings seen in our cases...
  47. Emanuel P, Mannion M, Phelps R. Complete regression of primary malignant melanoma. Am J Dermatopathol. 2008;30:178-81 pubmed publisher
    ..These cases illustrate the histologic features of a completely regressed primary melanoma and add credence to the theory that completely regressed melanoma is associated with a poor outcome...
  48. Hassan S, Knox M, Griffin M, Kennedy M. Spontaneous regression of metastatic Merkel cell carcinoma. Ir Med J. 2010;103:21-2 pubmed
    ..Here we present a case of complete spontaneous regression of metastatic Merkel cell carcinoma demonstrating a markedly different pattern of events from those previously published...
  49. Stiller B, Hetzer R, Meyer R, Dittrich S, Pees C, Alexi Meskishvili V, et al. Primary cardiac tumours: when is surgery necessary?. Eur J Cardiothorac Surg. 2001;20:1002-6 pubmed
    ..It is a challenge for paediatric cardiologists and surgeons to ascertain which patients need surgery and which will benefit from conservative follow-up...
  50. Hoption Cann S, van Netten J, van Netten C, Glover D. Spontaneous regression: a hidden treasure buried in time. Med Hypotheses. 2002;58:115-9 pubmed
    ..More than a century after its inception, Coley's vaccine and aggressive approach to treatment may still be one of most effective immunotherapies for cancer...
  51. Cui Z, Willingham M. Halo naevus: a visible case of immunosurveillance in humans?. Lancet Oncol. 2004;5:397-8 pubmed
  52. Christophersen A, Lie A, Fossa S. Unexpected 10 years complete remission after cortisone mono-therapy in metastatic renal cell carcinoma. Acta Oncol. 2006;45:226-8 pubmed
  53. Mohsin N, Budruddin M, Kamble P, Khalil M, Pakkyarra A, Jha A, et al. Complete regression of cutaneous B-cell lymphoma in a renal transplant patient after conversion from cyclosporin to sirolimus. Transplant Proc. 2007;39:1267-71 pubmed
    ..The patient remains well without clinical relapses at 19 months after conversion. Renal functions remained stable. We postulated that the antincoplastic properties of sirolimus may have played an active part in the positive outcome...
  54. Filippakis G, Zografos G, Pararas N, Lanitis S, Georgiadou D, Filippakis M. Spontaneous regression of rectal polyps following abdominal colectomy and ileorectal anastomosis for familial adenomatous polyposis, without sulindac treatment: report of four cases. Endoscopy. 2007;39:665-8 pubmed
    ..We present the cases of four patients with FAP treated by colectomy and ileorectal anastomosis, who had immediate, complete spontaneous regression of multiple polyps in the rectal stump, with no further need for sulindac treatment...
  55. Hausbrandt P, Leithner A, Beham A, Bodo K, Raith J, Windhager R. A rare case of infantile myofibromatosis and review of literature. J Pediatr Orthop B. 2010;19:122-6 pubmed publisher
  56. Choudhari K, McLorinan G, Byrnes D. Spontaneous regression of a primary cerebral tumour following postoperative middle cerebral artery territory infarction. Br J Neurosurg. 2001;15:177-9; discussion 179-80 pubmed
    ..We report a case of spontaneous regression of a cerebral oligodendroglioma following infarction in the territory of its feeding artery. Prospects of interventional technique as a part of multimodality treatment of gliomas are discussed...
  57. Demiri E, Pelissier P, Genin Etcheberry T, Tsakoniatis N, Martin D, Baudet J. Treatment of facial haemangiomas: the present status of surgery. Br J Plast Surg. 2001;54:665-74 pubmed
  58. Reynolds C. Ras and Seppuku in neuroblastoma. J Natl Cancer Inst. 2002;94:319-21 pubmed
  59. Ohguchi H, Sai T, Hamazaki Y, Hiwatashi K. [Cyclosporin A withdrawal causes spontaneous remission of recurrent subcutaneous tumors after allogeneic peripheral blood stem cell transplantation for adult T-cell leukemia/lymphoma]. Rinsho Ketsueki. 2003;44:102-7 pubmed
    ..At the time of writing, eight months after the transplant, remission has been maintained. A graft-versus-leukemia (GVL) effect may have been the curative action in this case...
  60. Partap S, Spence A. Spontaneously relapsing and remitting primary CNS lymphoma in an immunocompetent 45-year-old man. J Neurooncol. 2006;80:305-7 pubmed
    ..This case and a handful of others with single remissions emphasize that PCNSL cannot be reliably ruled out by improving or disappearing symptoms, signs or traditional MR imaging abnormalities...
  61. Naouri M, Lorette G. [Angiomas]. Rev Prat. 2006;56:1835-9 pubmed
  62. Ammar A, El Hammami S. [Tumor of the chest wall in a new born]. Ann Pathol. 2007;27:381-2 pubmed
  63. Wang E, Selleri S, Sabatino M, Monaco A, Pos Z, Worschech A, et al. Spontaneous and treatment-induced cancer rejection in humans. Expert Opin Biol Ther. 2008;8:337-49 pubmed
    ..On the other hand, it is also well documented that on rare occasions tumors can be dramatically destroyed by the host's immune response...
  64. Bischoff J. Progenitor cells in infantile hemangioma. J Craniofac Surg. 2009;20 Suppl 1:695-7 pubmed publisher
    ..In this paper, we discuss the literature that supports this emerging hypothesis...
  65. Trimble C, Peng S, Thoburn C, Kos F, Wu T. Naturally occurring systemic immune responses to HPV antigens do not predict regression of CIN2/3. Cancer Immunol Immunother. 2010;59:799-803 pubmed publisher
    ..This finding suggests that, in the setting of natural infection, immune responses which are involved in elimination of cervical dysplastic epithelium are not represented to any great extent in the systemic circulation...
  66. Wiman K. [New transcription factor-based cancer therapy. Gene therapy, cell lysis, reactivation of p53 are the new approaches]. Lakartidningen. 1997;94:3268-72 pubmed
    ..Moreover, it may be possible to restore the normal function of mutant p53 proteins by using small p53-activating molecules and thus inducing p53-dependent apoptosis in tumour cells...
  67. Kiyohara T, Kumakiri M, Kobayashi H, Shimizu T, Ohkawara A, Ohnuki M. A case of intravascular large B-cell lymphoma mimicking erythema nodosum: the importance of multiple skin biopsies. J Cutan Pathol. 2000;27:413-8 pubmed
  68. Iwanaka T, Yamamoto K, Ogawa Y, Arai M, Ito M, Kishimoto H, et al. Maturation of mass-screened localized adrenal neuroblastoma. J Pediatr Surg. 2001;36:1633-6 pubmed
    ..Herein, the authors report the maturation of mass-screened, localized adrenal neuroblastoma...
  69. Parekh S, Hebert T, Ratech H, Sparano J. Variable problems in lymphomas: CASE 3. Spontaneous regression of HIV-associated Burkitt's lymphoma of the cecum. J Clin Oncol. 2005;23:8116-7 pubmed
  70. Carriquiriborde M, Milocco S, Principi G, Cagliada P, Carbone C. [Pasteurella pneumotropica produces regression of human tumors transplanted in immunodeficiency mice]. Medicina (B Aires). 2006;66:242-4 pubmed
    ..However, the fact that a growing tumor regresses in the presence of the bacteria is an interesting observation which deserves further exploration in order to elucidate the mechanism involved...
  71. Kondo S, Okusaka T, Ueno H, Ikeda M, Morizane C. Spontaneous regression of hepatocellular carcinoma. Int J Clin Oncol. 2006;11:407-11 pubmed
    ..Another showed spontaneous regression after taking several complementary and alternative medicines. However, the mechanisms underlying this intriguing phenomenon remain unknown...
  72. Chan L, Smith G, Quaba A. The management of periorbital fat excess in haemangioma involution. J Plast Reconstr Aesthet Surg. 2008;61:133-7 pubmed
    ..Two were treated by blepharoplasty, during which an excess of fatty tissue was found, deep to the orbital septum. Birthmark stigmata were eradicated and symmetry was achieved...
  73. Katoh M, Imamura H, Yoshino M, Aoki T, Abumiya T, Aida T. Spontaneous regression of an anterior skull base mass. J Clin Neurosci. 2010;17:786-8 pubmed publisher
    ..Although the definition does include some types of malignant lesion, most masses are benign lesions that can regress spontaneously, as in our patient. A 'wait-and-see' policy is appropriate for such patients...
  74. Zimmermann A, Kappeler A, Friess H, Buchler M. Hepatocellular carcinoma with an unusual medullary-like histology and signs of regression ("medullary-like hepatocellular carcinoma"). Dig Liver Dis. 2002;34:748-53 pubmed
    ..Medullary-like hepatocellular carcinoma is a lesion which mimics several features known for other medullary carcinomas, including a marked immune response which may be responsible for partial regression of this tumour...
  75. Fontaine D, Parkhill W, Greer W, Walsh N. Partial regression of primary cutaneous melanoma: is there an association with sub-clinical sentinel lymph node metastasis?. Am J Dermatopathol. 2003;25:371-6 pubmed
  76. Cheng H, Tsai M. Regression of hepatocellular carcinoma spontaneous or herbal medicine related?. Am J Chin Med. 2004;32:579-85 pubmed
    ..We cannot be certain how significant the herbal preparation was in the regression of the hepatocellular carcinoma, but the regression of the tumor provides us a reason and hope for further research...
  77. Kao L, Yang M. Spontaneous regression of retinoblastoma in a Taiwan series. J Pediatr Ophthalmol Strabismus. 2005;42:228-32 pubmed
    ..To document the high occurrence of complete spontaneous regression of retinoblastoma in a Taiwan series...
  78. Matsumoto N, Ogawa M, Kawabata M, Tohne R, Hiroi Y, Furuta T, et al. Pseudolymphoma of the liver: Sonographic findings and review of the literature. J Clin Ultrasound. 2007;35:284-8 pubmed
    ..The imaging features of this tumor are discussed herein. The diagnosis of pseudolymphoma was achieved via sonographically guided biopsy. The lesion regressed completely within 1 year...
  79. Kubota M, Sueyoshi S, Fujita H, Fujii T, Yamana H, Shirouzu K. Spontaneous regression in small cell esophageal carcinoma. Jpn J Thorac Cardiovasc Surg. 2003;51:660-4 pubmed
    ..This may be the first case report that spontaneous regression in a small-cell carcinoma in the esophagus was found by esophagectomy and pathological examination...
  80. Nihei N, Hiruma M, Ikeda S, Ogawa H. A case of Bowen's disease showing a clinical tendency toward spontaneous regression. J Dermatol. 2004;31:569-72 pubmed
    ..At the patient's request, we chose to observe the progress of the lesion. We review the literature of cases of Bowen's disease that have shown a similar tendency toward spontaneous regression, which have been rare...
  81. Kato M, Ikeda Y, Namiki S, Saito S, Ito A, Arai Y. Spontaneous regression of pulmonary metastases from testicular embryonal carcinoma. Int J Urol. 2008;15:265-6 pubmed publisher
    ..Chemotherapy was not performed because the metastatic lesions continued to regress spontaneously. Six months later, no tumor was observed on computed tomography images of the lungs...
  82. Rozen W, Joseph S, Lo P. Spontaneous regression of low-grade gliomas in pediatric patients without neurofibromatosis. Pediatr Neurosurg. 2008;44:324-8 pubmed publisher
    ..In individual cases however, the natural history can be variable, and rarely spontaneous regression has been described. This paper describes factors associated with spontaneous regression...
  83. Mehl M, Withrow S, Seguin B, Powers B, Dernell W, Pardo A, et al. Spontaneous regression of osteosarcoma in four dogs. J Am Vet Med Assoc. 2001;219:614-7 pubmed
    ..Osteosarcoma in dogs has characteristics similar to that of OSA in humans...
  84. Miura K, Han G, Sano M, Tsutsui Y. Regression of congenital fibrosarcoma to hemangiomatous remnant with histological and genetic findings. Pathol Int. 2002;52:612-8 pubmed
    ..These genetic and histological changes suggest that the CFS either completely disappeared by apoptosis or showed mature transformation to hemangiomatous tissue with aging...
  85. Mangel J, Barth D, Berinstein N, Imrie K. Spontaneous regression of Hodgkin's disease: two case reports and a review of the literature. Hematology. 2003;8:191-6 pubmed
    ..Spontaneous regressions of Hodgkin's lymphoma are exceedingly rare. A review of the literature regarding spontaneous regressions of lymphoma and cancer in general is discussed...
  86. Hoption Cann S, van Netten J, van Netten C. Dr William Coley and tumour regression: a place in history or in the future. Postgrad Med J. 2003;79:672-80 pubmed
    ..It offers a rare opportunity for the development of a broadly applicable, relatively inexpensive, yet effective treatment for cancer. Even in cases beyond the reach of conventional therapy, there is hope...
  87. Matsumoto K, Yasugi T, Oki A, Fujii T, Nagata C, Sekiya S, et al. IgG antibodies to HPV16, 52, 58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia. Cancer Lett. 2006;231:309-13 pubmed
    ..Our data suggest that baseline IgG reactivities to HPV L1-capsids do not serve as a predictive marker of CIN regression, in contrast to histological CIN grades and HPV DNA status...
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