neoplasm micrometastasis


Summary: Newly arising secondary tumors so small they are difficult to detect by physical examination or routine imaging techniques.

Top Publications

  1. van Nijnatten T, Simons J, Moossdorff M, De Munck L, Lobbes M, van der Pol C, et al. Prognosis of residual axillary disease after neoadjuvant chemotherapy in clinically node-positive breast cancer patients: isolated tumor cells and micrometastases carry a better prognosis than macrometastases. Breast Cancer Res Treat. 2017;163:159-166 pubmed publisher
    ..Axillary nodal status ypN1-3 is associated with a less favorable prognosis. Future studies should consider ypN0 and ypNitc/mi as one entity. ..
  2. Zheng B, Ni C, Chen H, Wu W, Guo Z, Zhu Y, et al. New evidence guiding extent of lymphadenectomy for esophagogastric junction tumor: Application of Ber-Ep4 Joint with CD44v6 staining on the detection of lower mediastinal lymph node micrometastasis and survival analysis. Medicine (Baltimore). 2017;96:e6533 pubmed publisher
    ..As a positive prognostic factor, thorough lower mediastinal lymphadenectomy in an invasive approach should be considered when necessary. Ber-Ep4 and CD44v6 were shown to be great markers for detecting LNMM. ..
  3. Viehl C, Weixler B, Guller U, Dell Kuster S, Rosenthal R, Ramser M, et al. Presence of bone marrow micro-metastases in stage I-III colon cancer patients is associated with worse disease-free and overall survival. Cancer Med. 2017;6:918-927 pubmed publisher
    ..Future trials should evaluate whether node-negative colon cancer patients with BMM benefit from adjuvant chemotherapy. ..
  4. Mishra A, Datta S, Malik A, Garg A, Nair D, Nair S, et al. Role of microscopic spread beyond gross disease as an adverse prognostic factor in oral squamous cell carcinoma. Eur J Surg Oncol. 2017;43:1503-1508 pubmed publisher
    ..5 months in patients without MSGD (p < 0.002). Tumours with MSGD tend to have a higher incidence of nodal metastasis, PNI and thicker tumours. Presence of MSGD was associated with lower overall survival as compared to those without. ..
  5. Suh S, Choi Y. Predictors of Micrometastases in Patients with Barcelona Clinic Liver Cancer Classification B Hepatocellular Carcinoma. Yonsei Med J. 2017;58:737-742 pubmed publisher
    ..116; 95% CI, 0.027-0.497; p=0.004). AFP and PIVKA-II levels predict micrometastases and survival. Therefore, they should be considered when selecting SR for BCLC B HCC. ..
  6. Madekivi V, Boström P, Aaltonen R, Vahlberg T, Salminen E. The Sentinel Node with Isolated Breast Tumor Cells or Micrometastases. Benefits and Risks of Axillary Dissection. Anticancer Res. 2017;37:3757-3762 pubmed
    ..It is conceivable that the features of the primary tumor, rather than the amount of cancer cells in the SLN, might serve to identify patients in whom ALDN can be avoided. ..
  7. Núñez Bragayrac L, Murekeyisoni C, Vacchio M, Attwood K, Mehedint D, Mohler J, et al. Blinded review of archival radical prostatectomy specimens supports that contemporary Gleason score 6 prostate cancer lacks metastatic potential. Prostate. 2017;77:1076-1081 pubmed publisher
    ..Reduced postoperative monitoring is appropriate for pGS6, but may require pathology review to confirm absent Gleason pattern 4. ..
  8. Sloothaak D, van der Linden R, van de Velde C, Bemelman W, Lips D, van der Linden J, et al. Prognostic implications of occult nodal tumour cells in stage I and II colon cancer: The correlation between micrometastasis and disease recurrence. Eur J Surg Oncol. 2017;43:1456-1462 pubmed publisher
    ..5-37.4, p = 0.012). In this study, the incidence of MMs and ITCs in patients with stage I/II colon cancer was 4.2% and 19.3%, respectively. MMs were associated with an reduced 3 year disease free survival rate, but ITCs were not. ..
  9. Plante M, Stanleigh J, Renaud M, Sebastianelli A, Grondin K, Gregoire J. Isolated tumor cells identified by sentinel lymph node mapping in endometrial cancer: Does adjuvant treatment matter?. Gynecol Oncol. 2017;146:240-246 pubmed publisher
    ..Patients with ITCs and otherwise low-risk uterine disease probably derive little benefit from receiving additional treatments. More studies are needed to confirm our results. ..

More Information


  1. Weixler B, Viehl C, Warschkow R, Guller U, Ramser M, Sauter G, et al. Comparative Analysis of Tumor Cell Dissemination to the Sentinel Lymph Nodes and to the Bone Marrow in Patients With Nonmetastasized Colon Cancer: A Prospective Multicenter Study. JAMA Surg. 2017;152:912-920 pubmed publisher Identifier: NCT00826579. ..
  2. Collins M, O Donoghue C, Sun W, Zhou J, Ma Z, Laronga C, et al. Use of axillary lymph node dissection (ALND) in patients with micrometastatic breast cancer. J Surg Res. 2017;215:55-59 pubmed publisher
    ..Given that the risk of lymphedema after ALND ranges between 20%-53%, the morbidity of ALND may far exceed the likelihood of detecting further nodal involvement in women with micrometastatic disease: 7.1% in this series. ..
  3. Dai C, Xie H, Kadeer X, Su H, Xie D, Ren Y, et al. Relationship of Lymph Node Micrometastasis and Micropapillary Component and Their Joint Influence on Prognosis of Patients With Stage I Lung Adenocarcinoma. Am J Surg Pathol. 2017;41:1212-1220 pubmed publisher