viral cell transformation

Summary

Summary: An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.

Top Publications

  1. Giam C, Jeang K. HTLV-1 Tax and adult T-cell leukemia. Front Biosci. 2007;12:1496-507 pubmed
  2. Geiger T, Levitzki A. Loss of robustness and addiction to IGF1 during early keratinocyte transformation by human Papilloma virus 16. PLoS ONE. 2007;2:e605 pubmed
    ..We conclude that transformation in this model induces higher susceptibility of cells to stress due to reduced anti-apoptotic signaling and hyper-activation of p53 upon stress...
  3. Scaria V, Jadhav V. microRNAs in viral oncogenesis. Retrovirology. 2007;4:82 pubmed
    ..The host-virus crosstalk mediated by microRNAs, messenger RNAs and proteins, is complex and involves the different cellular regulatory layers. In this commentary, we describe models of microRNA mediated viral oncogenesis...
  4. Jones K, Petrow Sadowski C, Huang Y, Bertolette D, Ruscetti F. Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4(+) T cells. Nat Med. 2008;14:429-36 pubmed publisher
    ..In addition to altering the current paradigm concerning how HTLV-1 transmission occurs, these studies suggest that impairment of DC function after HTLV-1 infection plays a part in pathogenesis...
  5. Afonso P, Zamborlini A, Saib A, Mahieux R. Centrosome and retroviruses: the dangerous liaisons. Retrovirology. 2007;4:27 pubmed
    ..Enthrallingly, HTLV-1 Tax expression also targets the functions of the centrosome, and this event is correlated with centrosome amplification, aneuploidy and transformation...
  6. Higuchi M, Tsubata C, Kondo R, Yoshida S, Takahashi M, Oie M, et al. Cooperation of NF-kappaB2/p100 activation and the PDZ domain binding motif signal in human T-cell leukemia virus type 1 (HTLV-1) Tax1 but not HTLV-2 Tax2 is crucial for interleukin-2-independent growth transformation of a T-cell line. J Virol. 2007;81:11900-7 pubmed
  7. Overmeer R, Henken F, Bierkens M, Wilting S, Timmerman I, Meijer C, et al. Repression of MAL tumour suppressor activity by promoter methylation during cervical carcinogenesis. J Pathol. 2009;219:327-36 pubmed publisher
    ..Hence, MAL promoter methylation and/or mRNA expression analysis on cervical scrapings may provide a valuable diagnostic tool to improve the detection of CIN3, SCC, and AdCA...
  8. Cousens C, Maeda N, Murgia C, Dagleish M, Palmarini M, Fan H. In vivo tumorigenesis by Jaagsiekte sheep retrovirus (JSRV) requires Y590 in Env TM, but not full-length orfX open reading frame. Virology. 2007;367:413-21 pubmed
    ..In contrast, mutation of the JSRV open reading frame orfX, for which no function has yet been attributed, did not alter the disease induced by JSRV(21)...
  9. Zheng H, Li L, Hu D, Deng X, Cao Y. Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma. Cell Mol Immunol. 2007;4:185-96 pubmed
    ..Interfering LMP1 signaling could be a promising strategy to target the malignant phenotype of NPC...

More Information

Publications99

  1. Maeda N, Fan H. Signal transduction pathways utilized by enzootic nasal tumor virus (ENTV-1) envelope protein in transformation of rat epithelial cells resemble those used by jaagsiekte sheep retrovirus. Virus Genes. 2008;36:147-55 pubmed publisher
    ..These results indicate that the signaling pathways for ENTV and JSRV transformation are quite similar, consistent with the notion that these proteins do not determine the tissue-specificity of the tumors for these viruses...
  2. Arnold J, ZIMMERMAN B, Li M, Lairmore M, Green P. Human T-cell leukemia virus type-1 antisense-encoded gene, Hbz, promotes T-lymphocyte proliferation. Blood. 2008;112:3788-97 pubmed publisher
    ..Our data indicate that Hbz expression enhances the proliferative capacity of HTLV-1-infected T cells, playing a critical role in cell survival and ultimately HTLV-1 tumorigenesis in the infected host...
  3. Matsuoka M, Jeang K. Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation. Nat Rev Cancer. 2007;7:270-80 pubmed
    ..We also explore the contribution of a newly discovered protein and RNA on the HTLV-1 minus strand, HTLV-1 basic leucine zipper factor (HBZ), to the maintenance of virus-induced leukaemia...
  4. Maeda N, Fan H, Yoshikai Y. Oncogenesis by retroviruses: old and new paradigms. Rev Med Virol. 2008;18:387-405 pubmed publisher
    ..In this review, we will summarise research on retrovirus oncogenic transformation over the past 100 years since the first published report of an oncogenic virus with particular attention to Env-induced transformation...
  5. Jeon J, Shim S, Nam H, Baik S, Kim J, Han B. Copy number increase of 1p36.33 and mitochondrial genome amplification in Epstein-Barr virus-transformed lymphoblastoid cell lines. Cancer Genet Cytogenet. 2007;173:122-30 pubmed
    ..33 due to increased mitochondrial DNA copy numbers. Thus, analyses of array CGH profiles of diseases should take into account the potential for copy number variation of 1p36.33...
  6. Dutta J, Fan Y, Gupta N, Fan G, Gelinas C. Current insights into the regulation of programmed cell death by NF-kappaB. Oncogene. 2006;25:6800-16 pubmed
    ..These recent developments shed new light on the role of NF-kappaB in many disease conditions including tumor development, tumor progression and anticancer treatment...
  7. Nitta T, Kanai M, Sugihara E, Tanaka M, Sun B, Nagasawa T, et al. Centrosome amplification in adult T-cell leukemia and human T-cell leukemia virus type 1 Tax-induced human T cells. Cancer Sci. 2006;97:836-41 pubmed
    ..These findings suggest that Tax deregulates CDK activity and induces centrosome amplification, which might be associated with cellular transformation by HTLV-1 and chromosomal instability in HTLV-1-infected human T cells...
  8. Kuo Y, Giam C. Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence. EMBO J. 2006;25:1741-52 pubmed
    ..Finally, activation of APC ahead of schedule may be exploited to arrest cancer cell growth...
  9. Mutlu A, Cavallin L, Vincent L, Chiozzini C, Eroles P, Duran E, et al. In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma. Cancer Cell. 2007;11:245-58 pubmed
    ..These results show that KSHV malignancy is in vivo growth restricted and reversible, defining mECK36 as a biologically sensitive animal model of KSHV-dependent KS...
  10. Ishioka K, Higuchi M, Takahashi M, Yoshida S, Oie M, Tanaka Y, et al. Inactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type 1 Tax protein. Retrovirology. 2006;3:71 pubmed
    ..The interaction of human T-cell leukemia virus type 1 (HTLV-1) Tax1 protein with the tumor suppressor Dlg1 is correlated with cellular transformation...
  11. Hutchings I, Tierney R, Kelly G, Stylianou J, Rickinson A, Bell A. Methylation status of the Epstein-Barr virus (EBV) BamHI W latent cycle promoter and promoter activity: analysis with novel EBV-positive Burkitt and lymphoblastoid cell lines. J Virol. 2006;80:10700-11 pubmed
    ..Thus, studies of B cells with atypical patterns of Wp usage emphasize the strong correlation between the presence of unmethylated Wp sequences and promoter activity...
  12. Mesnard J, Barbeau B, Devaux C. HBZ, a new important player in the mystery of adult T-cell leukemia. Blood. 2006;108:3979-82 pubmed
    ..One report suggests that the HBZ gene might have a bimodal function (at the mRNA and protein levels), which could represent an uncharacterized strategy to regulate viral replication and proliferation of infected T cells...
  13. Trapp S, Parcells M, Kamil J, Schumacher D, Tischer B, Kumar P, et al. A virus-encoded telomerase RNA promotes malignant T cell lymphomagenesis. J Exp Med. 2006;203:1307-17 pubmed
    ..We concluded that vTR plays a critical role in MDV-induced T cell lymphomagenesis. Furthermore, our results provide the first description of tumor-promoting effects of TR in a natural virus-host infection model...
  14. Milne S, Ivanova P, Armstrong M, Myers D, Lubarda J, Shulga Y, et al. Dramatic differences in the roles in lipid metabolism of two isoforms of diacylglycerol kinase. Biochemistry. 2008;47:9372-9 pubmed publisher
  15. Cobbs C, Soroceanu L, Denham S, Zhang W, Kraus M. Modulation of oncogenic phenotype in human glioma cells by cytomegalovirus IE1-mediated mitogenicity. Cancer Res. 2008;68:724-30 pubmed publisher
    ..These findings indicate that HCMV IE1 can significantly affect important oncogenic signaling pathways in glioblastoma cells. ..
  16. Wang X, Jensen R, Lu Z. A novel environment-sensitive biodegradable polydisulfide with protonatable pendants for nucleic acid delivery. J Control Release. 2007;120:250-8 pubmed
    ..This novel polydisulfide is a promising lead for further design and development of safe and efficient delivery systems for nucleic acids. ..
  17. Nair V. Retrovirus-induced oncogenesis and safety of retroviral vectors. Curr Opin Mol Ther. 2008;10:431-8 pubmed
    ..Furthermore, insertional activation of non-coding sequences, such as microRNAs, in addition to insertional effects on protein-coding genes, should be examined when considering the risks of retroviral therapy. ..
  18. Takakuwa T, Tresnasari K, Rahadiani N, Miwa H, Daibata M, Aozasa K. Cell origin of pyothorax-associated lymphoma: a lymphoma strongly associated with Epstein-Barr virus infection. Leukemia. 2008;22:620-7 pubmed
    ..Most PAL cells were derived from crippled post-GC cells, which usually could not survive. Transformation of such B cells through EBV infection might provide a basis for the development of PAL with additional genetic changes. ..
  19. Xu D, Zhang L. Viral transformation for production of personalized type I interferons. Biotechnol J. 2010;5:578-81 pubmed publisher
    ..The personalized IFNs could have a longer circulation time, fewer side effects but higher efficacy. We anticipate that the system can provide an improved form of IFN for medical uses...
  20. Heuser M, Argiropoulos B, Kuchenbauer F, Yung E, Piper J, Fung S, et al. MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML. Blood. 2007;110:1639-47 pubmed
    ..MN1 is a unique oncogene in hematopoiesis that both promotes proliferation/self-renewal and blocks differentiation, and may become useful as a predictive marker in AML treatment. ..
  21. Capo Chichi C, Yeasky T, Heiber J, Wang Y, Barber G, Xu X. Explicit targeting of transformed cells by VSV in ovarian epithelial tumor-bearing Wv mouse models. Gynecol Oncol. 2010;116:269-75 pubmed publisher
    ..The results demonstrated the explicit targeting of ovarian epithelial tumors by VSV in immune competent, ovarian tumor-bearing mouse models, and further support the utility of VSV as an effective and safe anti-cancer agent. ..
  22. Liu X, Roberts J, Dakic A, Zhang Y, Schlegel R. HPV E7 contributes to the telomerase activity of immortalized and tumorigenic cells and augments E6-induced hTERT promoter function. Virology. 2008;375:611-23 pubmed publisher
    ..Thus, HPV E7 plays a role in the maintenance of telomerase activity in stable cell lines and augments acute, E6-induced hTERT promoter activity. ..
  23. Thorley Lawson D, Duca K, Shapiro M. Epstein-Barr virus: a paradigm for persistent infection - for real and in virtual reality. Trends Immunol. 2008;29:195-201 pubmed publisher
  24. Al Ubaidi M, Matsumoto H, Kurono S, Singh A. Proteomics profiling of the cone photoreceptor cell line, 661W. Adv Exp Med Biol. 2008;613:301-11 pubmed publisher
  25. Khalili K, Sariyer I, Safak M. Small tumor antigen of polyomaviruses: role in viral life cycle and cell transformation. J Cell Physiol. 2008;215:309-19 pubmed
    ..In this short review, we will focus on the structural and functional features of one polyomavirus transforming protein, that is, the small t-antigen of the human neurotropic JC virus (JCV) and the simian virus, SV40...
  26. Takedatsu H, Taylor K, Mei L, McGovern D, Landers C, Gonsky R, et al. Linkage of Crohn's disease-related serological phenotypes: NFKB1 haplotypes are associated with anti-CBir1 and ASCA, and show reduced NF-kappaB activation. Gut. 2009;58:60-7 pubmed publisher
    ..The results also show the use of EBV-transformed lymphoblastoid cell lines to conduct phenotypic studies of genetic variation. ..
  27. Zehbe I, Richard C, DeCarlo C, Shai A, Lambert P, Lichtig H, et al. Human papillomavirus 16 E6 variants differ in their dysregulation of human keratinocyte differentiation and apoptosis. Virology. 2009;383:69-77 pubmed publisher
    ..The combined differentiation and apoptosis pattern of high-risk E6 variants, especially of Q14H/H78Y/L83V, may reflect a phenotype beneficial to carcinogenesis and viral life cycle. ..
  28. Hu L, Plafker K, Vorozhko V, Zuna R, Hanigan M, Gorbsky G, et al. Human papillomavirus 16 E5 induces bi-nucleated cell formation by cell-cell fusion. Virology. 2009;384:125-34 pubmed publisher
    ..These findings identify a new role for HPV16 E5 and support a model in which complementary roles of the HPV16 oncogenes lead to the induction of carcinogenesis. ..
  29. Diallo A, Badescu D, Blanchette M, Makarenkov V. A whole genome study and identification of specific carcinogenic regions of the human papilloma viruses. J Comput Biol. 2009;16:1461-73 pubmed publisher
    ..Supplementary Material is provided (see online Supplementary Material at www.libertonline.com ). ..
  30. Epeldegui M, Breen E, Hung Y, Boscardin W, Detels R, Martinez Maza O. Elevated expression of activation induced cytidine deaminase in peripheral blood mononuclear cells precedes AIDS-NHL diagnosis. AIDS. 2007;21:2265-70 pubmed
    ..Additionally, AID expression was seen to differ depending on NHL subtype, with the highest levels of expression seen in those who developed Burkitt's lymphoma...
  31. zur Hausen H. A specific signature of Merkel cell polyomavirus persistence in human cancer cells. Proc Natl Acad Sci U S A. 2008;105:16063-4 pubmed publisher
  32. HOFFMAN B, Newman Tarr T, Gibbard A, Wang S, Hanning C, Pratta M, et al. Development and characterization of a human articular cartilage-derived chondrocyte cell line that retains chondrocyte phenotype. J Cell Physiol. 2010;222:695-702 pubmed publisher
  33. Riolobos L, Valle N, Hernando E, Maroto B, Kann M, Almendral J. Viral oncolysis that targets Raf-1 signaling control of nuclear transport. J Virol. 2010;84:2090-9 pubmed publisher
    ..Thus, Raf-1 control of nuclear translocation of MVM capsid assembly intermediates provides a novel target for viral oncolysis. MVM may reinforce specific therapies against frequent human cancers with deregulated Raf signaling. ..
  34. Qian L, Xie J, Ye F, Gao S. Kaposi's sarcoma-associated herpesvirus infection promotes invasion of primary human umbilical vein endothelial cells by inducing matrix metalloproteinases. J Virol. 2007;81:7001-10 pubmed
    ..Together, these results suggest that KSHV infection modulates the production of multiple MMPs to increase cell invasiveness and thus contributes to the pathogenesis of KSHV-induced malignancies. ..
  35. Haybaeck J, Zeller N, Wolf M, Weber A, Wagner U, Kurrer M, et al. A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell. 2009;16:295-308 pubmed publisher
    ..Thus, sustained LT signaling represents a pathway involved in hepatitis-induced HCC. ..
  36. Pipas J. SV40: Cell transformation and tumorigenesis. Virology. 2009;384:294-303 pubmed publisher
  37. McCloskey R, Menges C, Friedman A, Patel D, McCance D. Human papillomavirus type 16 E6/E7 upregulation of nucleophosmin is important for proliferation and inhibition of differentiation. J Virol. 2010;84:5131-9 pubmed publisher
    ..The results show for the first time that NPM is required for the proliferation and inhibition of differentiation observed in HPV E6- and E7-expressing primary cells. ..
  38. Nemajerova A, Talos F, Moll U, Petrenko O. Rb function is required for E1A-induced S-phase checkpoint activation. Cell Death Differ. 2008;15:1440-9 pubmed publisher
    ..Our results support the essential role of Rb and E2F1 in the regulation of genomic stability and DNA damage checkpoints. ..
  39. Suzuki S, Singhirunnusorn P, Mori A, Yamaoka S, Kitajima I, Saiki I, et al. Constitutive activation of TAK1 by HTLV-1 tax-dependent overexpression of TAB2 induces activation of JNK-ATF2 but not IKK-NF-kappaB. J Biol Chem. 2007;282:25177-81 pubmed
    ..These results indicate that Tax-mediated TAK1 activation is important for the activation of ATF2 rather than NF-kappaB. ..
  40. Haddad L, el Hajj H, Abou Merhi R, Kfoury Y, Mahieux R, El Sabban M, et al. KSHV-transformed primary effusion lymphoma cells induce a VEGF-dependent angiogenesis and establish functional gap junctions with endothelial cells. Leukemia. 2008;22:826-34 pubmed
    ..Angiogenesis, cell adhesion and communication likely contribute to the development of PEL and represent potential therapeutic targets. ..
  41. Gao G, Peng M, Zhu L, Wei Y, Wu X. Human papillomavirus 16 variant E7 gene induces transformation of NIH 3T3 cells via up-regulation of cdc25A and cyclin A. Int J Gynecol Cancer. 2009;19:494-9 pubmed publisher
    ..16- or HBE7.16-induced transformation of NIH 3T3 cells. In addition, higher transforming ability of HBE7.16 may be responsible for the increased mortality of cervical cancer in Wufeng County. ..
  42. Vijayachandra K, Higgins W, Lee J, Glick A. Induction of p16ink4a and p19ARF by TGFbeta1 contributes to growth arrest and senescence response in mouse keratinocytes. Mol Carcinog. 2009;48:181-186 pubmed publisher
  43. Torres M, Mayorga C, Blanca M. Nonimmediate allergic reactions induced by drugs: pathogenesis and diagnostic tests. J Investig Allergol Clin Immunol. 2009;19:80-90 pubmed
    ..Further studies are thus required in order to improve our understanding of NIRs and refine our diagnostic criteria. ..
  44. Liu X, Disbrow G, Yuan H, Tomaic V, Schlegel R. Myc and human papillomavirus type 16 E7 genes cooperate to immortalize human keratinocytes. J Virol. 2007;81:12689-95 pubmed
    ..The common factor in cell immortalization by the three gene sets (E6 + E7, Myc + E7, and hTERT + E7 genes) is the induction of telomerase activity. ..
  45. Hotta Y, Kaneko K, Inuma J, Inami Y, Aruga S, Shimaoka T, et al. Establishment of a peritoneal mesothelial cell line from a transgenic rat harbouring the temperature-sensitive simian virus 40 large T-antigen gene. Nephrol Dial Transplant. 2010;25:1825-32 pubmed publisher
    ..This cell line might be a useful tool for various types of in vitro biological research on peritoneal dialysis. ..
  46. Qu J, Lin J, Zhang S, Zhu Z, Ni C, Zhang S, et al. HBV DNA can bind to P53 protein and influence p53 transactivation in hepatoma cells. Biochem Biophys Res Commun. 2009;386:504-9 pubmed publisher
    ..In conclusions, our observations suggest that the interaction of HBV and p53 at the levels of protein-protein and DNA-protein, which resulted in inactivation of p53 transactivation. ..
  47. Schmid E, Roos H, Sauter W, Rickinger A, Jaehnert I, Eckardt Schupp F. Chromosome analysis of the differential radiosensitivity of an Epstein-Barr virus (EBV)-transformed B cell line and B and T lymphocytes from the same blood donor. Int J Radiat Biol. 2010;86:47-55 pubmed publisher
  48. Martinez I, Gardiner A, Board K, Monzon F, Edwards R, Khan S. Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells. Oncogene. 2008;27:2575-82 pubmed
    ..These findings may contribute to a better understanding of the molecular mechanisms involved in cervical carcinogenesis. ..
  49. Hoskins E, Morris T, Higginbotham J, Spardy N, Cha E, Kelly P, et al. Fanconi anemia deficiency stimulates HPV-associated hyperplastic growth in organotypic epithelial raft culture. Oncogene. 2009;28:674-85 pubmed publisher
    ..Our findings support a new role for FA pathways in the maintenance of differentiation-dependent cell cycle exit, with the implication that FA deficiencies may contribute to the high risk of FA patients for developing HPV-associated SCC. ..
  50. Jung H, Choi S, Kim J. Expression profiles of SV40-immortalization-associated genes upregulated in various human cancers. J Cell Biochem. 2009;106:703-13 pubmed publisher
    ..Identification and further characterization of these genes may provide insights of novel players for immortalization and human carcinogenesis. ..
  51. Xu J, Yun X, Jiang J, Wei Y, Wu Y, Zhang W, et al. Hepatitis B virus X protein blunts senescence-like growth arrest of human hepatocellular carcinoma by reducing Notch1 cleavage. Hepatology. 2010;52:142-54 pubmed publisher
    ..The correlation of inhibited Psen1-dependent Notch1 signaling and blunted senescence-like growth arrest was also observed in HBV-associated HCC patient tumor samples...
  52. Forte E, Luftig M. MDM2-dependent inhibition of p53 is required for Epstein-Barr virus B-cell growth transformation and infected-cell survival. J Virol. 2009;83:2491-9 pubmed publisher
    ..Finally, MDM2 antagonists may be considered for therapeutic intervention in EBV-associated malignancies expressing wild-type p53...
  53. Neiman P, Elsaesser K, Loring G, Kimmel R. Myc oncogene-induced genomic instability: DNA palindromes in bursal lymphomagenesis. PLoS Genet. 2008;4:e1000132 pubmed publisher
    ..Therefore, in addition to providing a platform for gene copy number change, palindromes may alter microRNA genes in a fashion that can contribute to cancer development...
  54. Varela M, Golder M, Archer F, de las Heras M, Leroux C, Palmarini M. A large animal model to evaluate the effects of Hsp90 inhibitors for the treatment of lung adenocarcinoma. Virology. 2008;371:206-15 pubmed
    ..Thus, OPA could be used as a large animal model for comprehensive studies investigating the effects of Hsp90 inhibitors in lung adenocarcinoma...
  55. Hatanaka H, Takada S, Choi Y, Fujiwara S, Soda M, Enomoto M, et al. Transforming activity of purinergic receptor P2Y, G-protein coupled, 2 revealed by retroviral expression screening. Biochem Biophys Res Commun. 2007;356:723-6 pubmed
    ..These results indicate an unexpected role of P2RY2 in the carcinogenesis of human cancers...
  56. Battle R, Clark B. Quantitative analysis of human leucocyte antigen expression during culture of Epstein-Barr virus-transformed cell lines using the dako QIFIKIT. Br J Biomed Sci. 2007;64:32-4 pubmed
  57. Yasmeen A, Bismar T, Dekhil H, Ricciardi R, Kassab A, Gambacorti Passerini C, et al. ErbB-2 receptor cooperates with E6/E7 oncoproteins of HPV type 16 in breast tumorigenesis. Cell Cycle. 2007;6:2939-43 pubmed publisher
    ..These findings provide evidence that the ErbB-2 receptor cooperates with high-risk HPVs in breast tumorigenesis via beta-catenin activation...
  58. Chen C, Johnston T, Jeon H, Gedaly R, McHugh P, Ranjan D. Cyclosporine promotes epstein-barr virus-infected human B-cell transformation assayed by three correlated assay methods. Transplant Proc. 2009;41:366-70 pubmed publisher
    ..05). In conclusion, CsA promoted EBV-B-cell transformation in three correlated assay methods in vitro using a model of posttransplant lymphoproliferative disorder...
  59. Li N, Yang R, Zhang W, Dorfman H, Rao P, Gorlick R. Genetically transforming human mesenchymal stem cells to sarcomas: changes in cellular phenotype and multilineage differentiation potential. Cancer. 2009;115:4795-806 pubmed publisher
    ..High-grade osteosarcomas frequently demonstrate the potential for multipotent differentiation and, along with several other lines of evidence, suggest that human mesenchymal stem cells (hMSC) might be the cell of origin...
  60. Kutz H, Reisbach G, Schultheiss U, Kieser A. The c-Jun N-terminal kinase pathway is critical for cell transformation by the latent membrane protein 1 of Epstein-Barr virus. Virology. 2008;371:246-56 pubmed
    ..Our data support a critical role of the LMP1-induced JNK pathway for proliferation of LMP1-transformed cells and characterize JNK as a potential target for intervention against EBV-induced malignancies...
  61. Huang L, Chao S, Lee B. Integration of human papillomavirus type-16 and type-18 is a very early event in cervical carcinogenesis. J Clin Pathol. 2008;61:627-31 pubmed
    ..Human papillomavirus (HPV) integration is a critical event in cervical carcinogenesis. The aim of this study was to explore the physical status of HPV-16 and HPV-18 during the progression of cervical precancerous lesions...
  62. Zhang J, Zhao P, Li R, Shi L, Cheng Z, You Y, et al. [Antiglioma activity of endothelial progenitor cells transduced with HSV-TK via inhibiting angiogenesis in vitro and in vivo]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009;26:170-4 pubmed publisher
    ..To investigate the potentiality of herpes simplex virus thymidine kinase transduced endothelial progenitor cells (EPC-TK) as angiogenesis-targeting vector in the glioma treatment in vitro and in vivo...
  63. Jeong S, Ryo A, Yamamoto N. The prolyl isomerase Pin1 stabilizes the human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein and promotes malignant transformation. Biochem Biophys Res Commun. 2009;381:294-9 pubmed publisher
    ..Our current study demonstrates an important role for Pin1 in the post-translational regulation of Tax and suggests that the targeting of Pin1 may offer a new insight into the pathogenesis of HTLV-1 related diseases...
  64. Fabarius A, Li R, Yerganian G, Hehlmann R, Duesberg P. Specific clones of spontaneously evolving karyotypes generate individuality of cancers. Cancer Genet Cytogenet. 2008;180:89-99 pubmed publisher
    ..This answers the age-old question, why even cancers of the same kind do not have consistent karyotypes...
  65. Kunz T, Mueller Steiner S, Schwerdtfeger K, Kleinert P, Troxler H, Kelm J, et al. Interaction of receptor-activity-modifying protein1 with tubulin. Biochim Biophys Acta. 2007;1770:1145-50 pubmed
    ..In conclusion, the findings point to biological roles of RAMP1 beyond its established interaction with G protein-coupled receptors...
  66. Ling P, Huls H. Isolation and immortalization of lymphocytes. Curr Protoc Mol Biol. 2005;Chapter 28:Unit 28.2 pubmed publisher
    ..In this unit, we describe simple procedures for production of EBV, isolation of lymphocytes, EBV infection of lymphocytes, and isolation of the resulting LCLs...
  67. Zhang F, Yang H, Wang Z, Mergler S, Liu H, Kawakita T, et al. Transient receptor potential vanilloid 1 activation induces inflammatory cytokine release in corneal epithelium through MAPK signaling. J Cell Physiol. 2007;213:730-9 pubmed
    ..Taken together, TRPV1 receptors may play a role in mediating corneal epithelial inflammatory mediator secretion and subsequent hyperalgesia...
  68. Stuber G, Flaberg E, Petranyi G, Otvos R, Rökaeus N, Kashuba E, et al. PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein. Mol Cancer. 2009;8:23 pubmed publisher
    ..We propose that PRIMA-1MET may reversibly inhibit cellular chaperons that prevent the aggregation of misfolded proteins, and that EBNA-5 may serve as a surrogate drug target for elucidating the precise molecular action of PRIMA-1MET...
  69. Haugen T, Lace M, Ishiji T, Sameshima A, Anson J, Turek L. Cellular factors are required to activate bovine papillomavirus-1 early gene transcription and to establish viral plasmid persistence but are not required for cellular transformation. Virology. 2009;389:82-90 pubmed publisher
    ..We conclude that cellular factors necessary for activating viral early gene transcription, establishment of viral plasmid replication and cell immortalization are not required during the maintenance phase of BPV-1 infection...
  70. Yamaguchi T, Ichise T, Iwata O, Hori A, Adachi T, Nakamura M, et al. Development of a new method for isolation and long-term culture of organ-specific blood vascular and lymphatic endothelial cells of the mouse. FEBS J. 2008;275:1988-98 pubmed publisher
    ..These results show that our transgenic cell culture system is useful for culturing murine endothelial cells, and will provide an accessible method and applications for studying endothelial cell biology...
  71. Stewart M, MacKay N, Hanlon L, Blyth K, Scobie L, Cameron E, et al. Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas. Cancer Res. 2007;67:5126-33 pubmed
  72. Hellner K, Mar J, Fang F, Quackenbush J, M nger K. HPV16 E7 oncogene expression in normal human epithelial cells causes molecular changes indicative of an epithelial to mesenchymal transition. Virology. 2009;391:57-63 pubmed publisher
    ..Hence, HPV16 oncoproteins may contribute to malignant progression through EMT induction...
  73. Everly D, Mainou B, Raab Traub N. The ID proteins contribute to the growth of rodent fibroblasts during LMP1-mediated transformation. Virology. 2008;376:258-69 pubmed publisher
    ..These data indicate that overexpression of the Id proteins is not sufficient for the effects of LMP1 on the cell cycle but that inhibition of Id expression does affect the growth of LMP1-transformed and parental Rat1 cells...
  74. Maliekal T, Bajaj J, Giri V, Subramanyam D, Krishna S. The role of Notch signaling in human cervical cancer: implications for solid tumors. Oncogene. 2008;27:5110-4 pubmed publisher
    ..Better animal model systems and identification of human cervical cancer stem cells should help clarify the possible stage specific and pleiotropic effects and regulation of Notch signaling...
  75. Paternoster L, Radogna F, Accorsi A, Cristina Albertini M, Gualandi G, Ghibelli L. Melatonin as a modulator of apoptosis in B-lymphoma cells. Ann N Y Acad Sci. 2009;1171:345-9 pubmed publisher
  76. Mizobe T, Tsukada J, Higashi T, Mouri F, Matsuura A, Tanikawa R, et al. Constitutive association of MyD88 to IRAK in HTLV-I-transformed T cells. Exp Hematol. 2007;35:1812-22 pubmed
    ..In this study, we investigated whether MyD88, an adaptor protein of Toll-like receptor (TLR) signaling, contributes to constitutive NF-kappaB activation in HTLV-I-transformed T cells...
  77. Jesnowski R, Zubakov D, Faissner R, Ringel J, Hoheisel J, Losel R, et al. Genes and proteins differentially expressed during in vitro malignant transformation of bovine pancreatic duct cells. Neoplasia. 2007;9:136-46 pubmed
    ..Thus, we were able to establish an in vitro model of pancreatic carcinogenesis, which enabled us to identify genes and proteins differentially expressed during the early steps of malignant transformation...
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    ..These findings identify a new signaling pathway that is uniquely activated by the TRAF-binding domain of LMP1 and is required for transformation...
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    ..We do demonstrate, however, that IL-2 stimulation and p12 expression significantly increased the rate of syncytium formation, revealing a novel role for IL-2 signaling and Jak activation in HTLV-1 virus transmission...
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    ..This review summarises current knowledge of the pathogenesis of HL with particular emphasis on the association with EBV...
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    ..However, its N-terminal half, N-TAIP, is rather well conserved in a much broader set of TTV isolates. The similarities between apoptin and TAIP, and their relevance for the development and treatment of diseases is discussed...
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    ..We conclude that the association and altered regulation of IRS proteins by Ad5E1A contribute to the adenovirus-transformed phenotype and modulates viral infection in an Akt-dependent manner...
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    ..The aim is to verify if a punctate pattern could be a marker of CIN1 that progresses...
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    ..This study assessed eight stages of hepatitis C virus (HCV) induced hepatocellular carcinoma (HCC) to search for appropriate genes for normalization...
  88. zur Hausen A. [Merkel cell polyomavirus in the pathogenesis of non-melanoma skin cancer]. Pathologe. 2009;30 Suppl 2:217-20 pubmed publisher
    ..Although MCPyV is present in the tumor cells of squamous cell carcinoma, Bowen's disease and basal cell skin carcinoma, further investigations into the role of MCPyV in the pathogenesis of these tumors is needed...
  89. Akgul B, Ghali L, Davies D, Pfister H, Leigh I, Storey A. HPV8 early genes modulate differentiation and cell cycle of primary human adult keratinocytes. Exp Dermatol. 2007;16:590-9 pubmed
    ..Expression of individual genes or in combination differentially influenced cell morphology and cell cycle distribution which might be important in HPV8-induced keratinocyte transformation...
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    ..In this article we examine the many contributions that have come from the small DNA tumor virus field and provide a recounting of some of the major landmark discoveries...