neoplastic processes


Summary: The pathological mechanisms and forms taken by tissue during degeneration into a neoplasm and its subsequent activity.

Top Publications

  1. Arendt L, Evans L, Rugowski D, Garcia Barchino M, Rui H, Schuler L. Ovarian hormones are not required for PRL-induced mammary tumorigenesis, but estrogen enhances neoplastic processes. J Endocrinol. 2009;203:99-110 pubmed publisher
    ..Mammary pERK1/2 and pAkt, but not phosphorylated Stat5, were markedly elevated by local PRL. Together, these findings indicate that PRL employs multiple mechanisms to promote mammary tumorigenesis...
  2. Strunecka A, Hynie S, Klenerova V. Role of oxytocin/oxytocin receptor system in regulation of cell growth and neoplastic processes. Folia Biol (Praha). 2009;55:159-65 pubmed
    ..The discovery of novel oxytocin receptor-linked signalling cascades brings interesting knowledge opening new avenues for research in oncology and molecular pharmacology with perspectives of finding new therapeutic agents...
  3. Stenson W. Toll-like receptors and intestinal epithelial repair. Curr Opin Gastroenterol. 2008;24:103-7 pubmed publisher
  4. Pulka M, Milewicz T, Gosztyła K, Lurzyńska M, Opiła J, Stochmal E, et al. [The impact of polichlorinated biphenyls on neoplastic processes]. Przegl Lek. 2010;67:1335-9 pubmed
    ..The structure and turnover of polichlorinated biphenyls (PCB) in environment was presented. The PCB absorption and metabolism in organisms as well as the PCB influence on neoplastic process. ..
  5. Dourado R, Porto L, Leitão Á, Cerqueira P, dos Santos J, Ramalho L, et al. Immunohistochemical Characterization of Cancer-associated Fibroblasts in Oral Squamous Cell Carcinoma. Appl Immunohistochem Mol Morphol. 2017;: pubmed publisher
    ..In neoplastic processes such as oral squamous cell carcinoma (OSCC), myofibroblasts are recognized as cancer-associated fibroblasts ..
  6. Aqil B, Xie W, Szigeti R. Lambda Immunoglobulin Light Chain Restricted B Cells in the Ascitic Fluid in Association with Terminal Ileal Florid Follicular Hyperplasia. Ann Clin Lab Sci. 2016;46:87-9 pubmed
    Distinguishing reactive changes from neoplastic processes during lymphoid tissue evaluation is oftentimes difficult...
  7. McGovern E, Lewis M, Niesley M, Huynh N, Hoag J. Retrospective analysis of the influence of 25-hydroxyvitamin D on disease progression and survival in pancreatic cancer. Nutr J. 2016;15:17 pubmed publisher
    Vitamin D deficiency is implicated in neoplastic processes in multiple organs, including the pancreas...
  8. Korkmaz A, Reiter R. Epigenetic regulation: a new research area for melatonin?. J Pineal Res. 2008;44:41-4 pubmed
    ..In this review, the potential role of melatonin in inhibiting DNA methyltransferase and epigenetic regulation is discussed. ..
  9. El Zayadi A. Heavy smoking and liver. World J Gastroenterol. 2006;12:6098-101 pubmed

More Information


  1. Ressel L, Ward S, Kipar A. Equine Cutaneous Mast Cell Tumours Exhibit Variable Differentiation, Proliferation Activity and KIT Expression. J Comp Pathol. 2015;153:236-43 pubmed publisher
    ..not been assessed or related to biological behaviour, and there is discussion as to whether CMCTs are true neoplastic processes. The present study describes 45 equine CMCTs in terms of their morphology and KIT and PCNA expression by ..
  2. Kim D, Oh S, Kwon H, Lee S, Kwon K, Kim B, et al. Clinical significances of preoperative serum interleukin-6 and C-reactive protein level in operable gastric cancer. BMC Cancer. 2009;9:155 pubmed publisher
    ..Preoperative high IL-6 levels were proposed as a poor prognostic factor for disease recurrence and overall survival in patients with gastric cancers. ..
  3. Smith M, Portier C. Incorporating observability thresholds of tumors into the two-stage carcinogenesis model. Math Biosci. 2000;163:75-89 pubmed
    ..The approach is also shown to be potentially useful with tumor observability thresholds having more complicated features. ..
  4. Papaioannou V, Mebazaa A, Plaud B, Legrand M. 'Chronomics' in ICU: circadian aspects of immune response and therapeutic perspectives in the critically ill. Intensive Care Med Exp. 2014;2:18 pubmed publisher
    ..Thus, besides neoplastic processes, critical illness could be linked to what has been referred as 'chronomics': timing and rhythm...
  5. Geng L, Huang D, Liu J, Qian Y, Deng J, Li D, et al. B7-H1 up-regulated expression in human pancreatic carcinoma tissue associates with tumor progression. J Cancer Res Clin Oncol. 2008;134:1021-7 pubmed publisher
    ..This expression seemed to be related to the ability of B7-H1 to promoting IL-10 secretion. ..
  6. Szabo E, Goheer A, Witschi H, Linnoila R. Overexpression of CC10 modifies neoplastic potential in lung cancer cells. Cell Growth Differ. 1998;9:475-85 pubmed
    ..These data suggest that loss of CC10 may contribute to carcinogenesis, because CC10 antagonizes the neoplastic phenotype. ..
  7. Demicheli R, Retsky M, Hrushesky W, Baum M. Tumor dormancy and surgery-driven interruption of dormancy in breast cancer: learning from failures. Nat Clin Pract Oncol. 2007;4:699-710 pubmed
  8. Kim W, Kim M, Moon H, Yuan P, Kim J, Woo J, et al. Differential impacts of insulin-like growth factor-binding protein-3 (IGFBP-3) in epithelial IGF-induced lung cancer development. Endocrinology. 2011;152:2164-73 pubmed publisher
    ..These data show that IGF-I is overexpressed in NSCLC, leading to activation of IGF-IR, and that IGFBP-3, depending on its expression level, either inhibits or potentiates IGF-I actions in lung carcinogenesis. ..
  9. Stapfer M, Hu J, Wei D, Groshen S, Beart R. Establishment of a nude mouse model of hepatic metastasis for evaluation of targeted retroviral gene delivery. J Surg Oncol. 2003;82:121-30; discussion 131 pubmed
    ..We have established a reproducible nude mouse model of liver metastasis, and demonstrated the feasibility of gene delivery to metastatic tumor nodules in vivo by portal vein infusions of a matrix-targeted retroviral vector. ..
  10. Chau W, Ip C, Mak A, Lai H, Wong A. c-Kit mediates chemoresistance and tumor-initiating capacity of ovarian cancer cells through activation of Wnt/?-catenin-ATP-binding cassette G2 signaling. Oncogene. 2013;32:2767-81 pubmed publisher
    ..The tumor-promoting microenvironment, such as hypoxia, could promote OTICs via upregulation of c-Kit expression. These results unravel an integral role for c-Kit in ovarian neoplastic processes and shed light on its mechanisms of action.
  11. Gaddey H. Oral manifestations of systemic disease. Gen Dent. 2017;65:23-29 pubmed
    ..Systemic diseases with oral findings include autoimmune, hematologic, endocrine, and neoplastic processes. Autoimmune disease may manifest as oral ulcerations, changes in the salivary and parotid glands, and ..
  12. Itano N, Zhuo L, Kimata K. Impact of the hyaluronan-rich tumor microenvironment on cancer initiation and progression. Cancer Sci. 2008;99:1720-5 pubmed publisher
    ..Hyaluronan in the tumor microenvironment thus significantly impacts cancer initiation and progression via stroma-cancer cell interactions. ..
  13. Li H, Cheng J, Dong N, Cui C, Diao T, Zhou X. Effects of endoscopic mucosal resection in patients with low-grade intraepithelial dysplasia of esophageal squamous cells. Dig Surg. 2013;30:302-8 pubmed publisher
    ..The percentage rate of regression of LGD was increased in the EMR treatment group as compared to that of the control group. EMR may prevent or delay the progression of LGD to HGD. ..
  14. Hou J, Herlitz L. Renal Infections. Surg Pathol Clin. 2014;7:389-408 pubmed publisher
    ..It is crucially important to separate infectious processes in the kidney from other inflammatory or neoplastic processes, as this will have a major impact on therapy...
  15. Yao X, Ping Y, Bian X. Contribution of cancer stem cells to tumor vasculogenic mimicry. Protein Cell. 2011;2:266-72 pubmed publisher
    ..We also discuss the potential mechanisms and possible interaction of CSCs with various elements in tumor microenvironment niche. Based on the importance of VM in tumor progression, it constitutes a novel therapeutic target for cancer. ..
  16. Looi L, Ng M, Cheah P. Telomerase activation in neoplastic cell immortalization and tumour progression. Malays J Pathol. 2007;29:33-5 pubmed
    ..These findings support a contributory role for telomerase in tumourigenesis with activation occurring from neoplastic transformation and increasing with tumour progression. ..
  17. Batouli A, Braun J, Singh K, Gholamrezanezhad A, Casagranda B, Alavi A. Diagnosis of non-osseous spinal metastatic disease: the role of PET/CT and PET/MRI. J Neurooncol. 2018;138:221-230 pubmed publisher
    ..PET is able to diagnose several neoplastic processes before any detectable morphological changes can be identified by anatomic imaging modalities alone...
  18. Yonezawa S, Nakamura A, Horinouchi M, Sato E. The expression of several types of mucin is related to the biological behavior of pancreatic neoplasms. J Hepatobiliary Pancreat Surg. 2002;9:328-41 pubmed
    ..Our study of the mucin expression pattern in IDC and IPMN shows that this pattern may be related to the biological behavior of pancreatic tumors and their malignant potential. ..
  19. Wu F, Wang Z, Cao Y, Chen W, Bai J, Zou J, et al. A randomised clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localised breast cancer. Br J Cancer. 2003;89:2227-33 pubmed
    ..It is concluded that, as a noninvasive therapy, HIFU could be effective, safe, and feasible in the extracorporeal treatment of localised breast cancer. ..
  20. Piche B, Li G. Inhibitor of growth tumor suppressors in cancer progression. Cell Mol Life Sci. 2010;67:1987-99 pubmed publisher
    ..The aim of this review is to summarize the different roles of ING family tumor suppressors in cancer progression and the molecular mechanisms involved. ..
  21. Dumont N, Arteaga C. The tumor microenvironment: a potential arbitrator of the tumor suppressive and promoting actions of TGFbeta. Differentiation. 2002;70:574-82 pubmed
  22. Yamamoto M, Urakawa H, Nishida Y, Hirata H. Secondary aneurysmal bone cyst in the distal humerus after resection of intra-articular nodular fasciitis of the elbow. BMC Res Notes. 2015;8:311 pubmed publisher
    ..Secondary aneurysmal bone cysts are associated with other neoplastic processes. Intra-articular nodular fasciitis in the elbow joint has not been reported previously, nor has the ..
  23. Rak J, Guha A. Extracellular vesicles--vehicles that spread cancer genes. Bioessays. 2012;34:489-97 pubmed publisher
  24. Sachdev S, Bu Y, Gelman I. Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion. BMC Cancer. 2009;9:12 pubmed publisher
    ..These data suggest that phosphorylation of Src substrates is a dynamic process, influenced temporally and spatially by factors such as FAK and adhesion. ..
  25. Vergauwen M, Perillo M, Garces Descovich A, Barrows C, Moser A, Mortelé K. Radiologic evaluation of patients undergoing the modified Appleby procedure for locally advanced pancreatic neoplasms: a case series. Abdom Radiol (NY). 2018;43:467-475 pubmed publisher medical and surgical care, pancreatic ductal adenocarcinoma remains one of the most locally aggressive neoplastic processes in the abdomen...
  26. Chow J, Kabani R, Lithgow K, Sarna M. Xanthogranulomatous pyelonephritis presenting as acute pleuritic chest pain: a case report. J Med Case Rep. 2017;11:101 pubmed publisher
    ..A broad differential diagnosis for various infectious, inflammatory/autoimmune, and neoplastic processes was considered...
  27. Mansour J, Schwarz R. Pathologic response to preoperative therapy: does it mean what we think it means?. Ann Surg Oncol. 2009;16:1465-79 pubmed publisher
    ..In addition, we address some alternative strategies to gauge the response of a tumor to preoperative therapy. ..
  28. Magnus N, Garnier D, Meehan B, McGraw S, Lee T, Caron M, et al. Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations. Proc Natl Acad Sci U S A. 2014;111:3544-9 pubmed publisher
    ..We postulate that procoagulant events in the tissue microenvironment (niche) may affect the fate of occult tumor cells, including their biological and genetic progression to initiate a full-blown malignancy. ..
  29. Stura I, Venturino E, Guiot C. A two-clones tumor model: Spontaneous growth and response to treatment. Math Biosci. 2016;271:19-28 pubmed publisher
    ..Furthermore, a treatment that eradicates only the primary tumor, having a low kill rate on the metastases, is ultimately not successful but promotes a "growth spurt" in the latter. ..
  30. Somasundar P, Yu A, Vona Davis L, McFadden D. Differential effects of leptin on cancer in vitro. J Surg Res. 2003;113:50-5 pubmed
    ..Recent studies have shown that leptin stimulates proliferation of human colon cancer in vitro. We hypothesized that leptin would have stimulatory effects on other human cancers...
  31. Resende C, Thiel A, Machado J, Ristimaki A. Gastric cancer: basic aspects. Helicobacter. 2011;16 Suppl 1:38-44 pubmed publisher
    ..It also addressed the role of the inflammatory mediator cyclooxygenase-2 (COX-2) in the process of gastric carcinogenesis and its importance as a potential molecular target for therapy...
  32. Kelloff G, O Shaughnessy J, Gordon G, Hawk E, Sigman C. Counterpoint: Because some surrogate end point biomarkers measure the neoplastic process they will have high utility in the development of cancer chemopreventive agents against sporadic cancers. Cancer Epidemiol Biomarkers Prev. 2003;12:593-6 pubmed
  33. Ahmad S, Berman R, Ellis L. Biology of colorectal liver metastases. Surg Oncol Clin N Am. 2003;12:135-50 pubmed
    ..Therapy to down-regulate or interrupt the last stages of metastases, proliferation, and angiogenesis and mechanisms to disrupt cell survival signals appear to be the most promising areas of investigation...
  34. Ahmad I, Patel R, Liu Y, Singh L, Taketo M, Wu X, et al. Ras mutation cooperates with ?-catenin activation to drive bladder tumourigenesis. Cell Death Dis. 2011;2:e124 pubmed publisher
    ..Taken together these data definitively show Ras pathway activation strongly cooperates with Wnt signalling to drive UCC in vivo...
  35. Wang D, DuBois R. Eicosanoids and cancer. Nat Rev Cancer. 2010;10:181-93 pubmed publisher
    ..Understanding the molecular mechanisms underlying the role of prostaglandins and other eicosanoids in cancer progression will help to develop more effective cancer chemopreventive and/or therapeutic agents...
  36. Li X, Lv Y, Yuan A, Li Z. Gastrin-releasing peptide links stressor to cancer progression. J Cancer Res Clin Oncol. 2010;136:483-91 pubmed publisher
    ..In this review, we will discuss the mechanisms and implications of GRP linking stressor to cancer progression...
  37. Borowicki A, Stein K, Scharlau D, Glei M. Fermentation supernatants of wheat ( Triticum aestivum L.) aleurone beneficially modulate cancer progression in human colon cells. J Agric Food Chem. 2010;58:2001-7 pubmed publisher
    ..9-22.2-fold). In conclusion, fermented wheat aleurone is able to act as a secondary chemopreventive agent by modulating parameters of cell growth and survival, whereas cells of an early transformation stage are more sensitive...
  38. Lynch C, Matrisian L. Matrix metalloproteinases in tumor-host cell communication. Differentiation. 2002;70:561-73 pubmed
    ..Therefore, the MMPs can no longer be thought of solely as ECM destructionists, but as part of an elegant communication system through which the tumor interacts with the stroma...
  39. Laiho M. [Understanding carcinogenesis]. Duodecim. 2002;118:1751-8 pubmed
  40. Mariani L, Siegenthaler P, Guzman R, Friedrich D, Fathi A, Ozdoba C, et al. The impact of tumour volume and surgery on the outcome of adults with supratentorial WHO grade II astrocytomas and oligoastrocytomas. Acta Neurochir (Wien). 2004;146:441-8 pubmed
    ..The study was performed to elucidate the impact of tumour volume and surgical resection on the long-term outcome of patients with supratentorial, diffuse, World Health Organization (WHO) grade II astrocytomas and oligo-astrocytomas...
  41. Lefter L, Sunamura M, Furukawa T, Yastsuoka T, Abe H, Inoue H, et al. Functional analysis of chromosome 18 in pancreatic cancer: strong evidence for new tumour suppressor genes. Asian J Surg. 2004;27:85-92 pubmed
    ..This study was intended to provide functional evidence for the existence of new tumour suppressor gene(s) located on chromosome 18...
  42. Shelton B. Introduction to colorectal cancer. Semin Oncol Nurs. 2002;18:2-12 pubmed
    ..To provide an overview of colorectal carcinoma (CRC), including current treatment strategies for various stages of the disease...
  43. Chang Y, Zuka M, Perez Pinera P, Astudillo A, Mortimer J, Berenson J, et al. Secretion of pleiotrophin stimulates breast cancer progression through remodeling of the tumor microenvironment. Proc Natl Acad Sci U S A. 2007;104:10888-93 pubmed
  44. Zalaudek I, Ferrara G, Argenziano G. Dermoscopy insights into nevogenesis: "Abtropfung" vs "Hochsteigerung". Arch Dermatol. 2007;143:284 pubmed
  45. Graaf M, Richel D, Van Noorden C, Guchelaar H. Effects of statins and farnesyltransferase inhibitors on the development and progression of cancer. Cancer Treat Rev. 2004;30:609-41 pubmed
  46. Cassarino D, DeRienzo D, Barr R. Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification--part two. J Cutan Pathol. 2006;33:261-79 pubmed
  47. Almeida M, Muchow M, Boikos S, Bauer A, Griffin K, Tsang K, et al. Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/- or Rb1+/- backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signaling. Hum Mol Genet. 2010;19:1387-98 pubmed publisher
  48. Ge F, Zhang L, Tao S, Kitazato K, Zhang Z, Zhang X, et al. Quantitative proteomic analysis of tumor reversion in multiple myeloma cells. J Proteome Res. 2011;10:845-55 pubmed publisher
    ..Our results provide novel insights into the mechanisms of tumor reversion and suggest new alternative approaches for MM treatment...
  49. Souter L, Andrews J, Zhang G, Cook A, Postenka C, Al Katib W, et al. Human 21T breast epithelial cell lines mimic breast cancer progression in vivo and in vitro and show stage-specific gene expression patterns. Lab Invest. 2010;90:1247-58 pubmed publisher
    ..This system thus reveals potential therapeutic targets and will provide a means of testing the influences of identified genes on transitions between these stages of pre-malignant to malignant growth...
  50. Yang N, Nijhuis E, Volders H, Eijsink J, Lendvai A, Zhang B, et al. Gene promoter methylation patterns throughout the process of cervical carcinogenesis. Cell Oncol. 2010;32:131-43 pubmed publisher
    ..To determine methylation status of nine genes, previously described to be frequently methylated in cervical cancer, in squamous intraepithelial lesions (SIL)...
  51. Bertuzzi A, Gandolfi A. Cell kinetics in a tumour cord. J Theor Biol. 2000;204:587-99 pubmed
    ..The model was used to compute the profile of the oxygen tension within the cord. Possible modifications and extensions are also presented...
  52. Tsodikov A, Muller W. Modeling carcinogenesis under a time-changing exposure. Math Biosci. 1998;152:179-91 pubmed
    ..The model is used to revisit the analysis by Yakovlev et al. [A. Yakovlev, W. Müller. L. Pavlova, E. Polig, Math. Biosci. 142 (1997) 107] of lymphoma-free survival in irradiated mice under acute and fractionated exposure...
  53. Negri S, Formentini G, Aletto A, Azzolini D. [Intravascular malignant lymphoma: report of a case]. Pathologica. 1997;89:527-30 pubmed
    ..A bilateral papillar renal necrosis was detected. This necrosis, not mentioned by the preceding literature, was, in all probability, caused by alterations of the microcirculation...
  54. Cassarino D, DeRienzo D, Barr R. Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification. Part one. J Cutan Pathol. 2006;33:191-206 pubmed
  55. Tobi M, Kam M, Ullah N, Qureshi K, Yordanova V, Hatfield J, et al. An anti-adenoma antibody, Adnab-9, may reflect the risk for neoplastic progression in familial hamartomatous polyposis syndromes. Dig Dis Sci. 2008;53:723-9 pubmed
    ..Adnab-9 labeling of PCs in the epithelial elements of hamartomatous colonic lesions of hereditary hamartomatous syndrome patients reflects the predisposition to colorectal cancer, further justifying early intervention strategies...
  56. Tan B, Park C, Ailles L, Weissman I. The cancer stem cell hypothesis: a work in progress. Lab Invest. 2006;86:1203-7 pubmed
  57. Sole R, Rodriguez Caso C, Deisboeck T, Saldaña J. Cancer stem cells as the engine of unstable tumor progression. J Theor Biol. 2008;253:629-37 pubmed publisher
    ..This dominant population is in fact separated from the low-mutation compartment by an instability gap, where almost no cancer cells are observed. The possible implications of this prediction are discussed...
  58. Verburg F, Mäder U, Luster M, Reiners C. Primary tumour diameter as a risk factor for advanced disease features of differentiated thyroid carcinoma. Clin Endocrinol (Oxf). 2009;71:291-7 pubmed publisher
    ..To study the relationship between primary tumour size and the risk of advanced disease features (multifocal or locally invasive disease, lymph-node or distant metastases) in differentiated thyroid carcinoma (DTC)...
  59. Hill Bator A, Opolski A. [Biological activity of synthetic analogs of laminin active sequences: YIGSR, RGD, SIKVAV]. Postepy Hig Med Dosw. 2002;56:579-88 pubmed
    ..In contrary, the sequence SIKVAV initiates angiogenesis and tumor progression. Moreover, laminin plays also other functions in human organism. One of them is the influence on platelet aggregation and thrombogenesis...
  60. Koo V, El Mekabaty A, Hamilton P, Maxwell P, Sharaf O, Diamond J, et al. Novel in vitro assays for the characterization of EMT in tumourigenesis. Cell Oncol. 2010;32:67-76 pubmed publisher
    ..Two novel assays quantifying Epithelial to Mesenchymal Transition (EMT) were compared to traditional motility and migration assays. TGF-beta1 treatment of AY-27 rat bladder cancer cells acted as a model of EMT in tumourigenesis...
  61. Norton L. Tumor dormancy: separating observations from experimental science. Nat Clin Pract Oncol. 2007;4:671 pubmed
  62. Watanabe A, Hoshino D, Hosino D, Koshikawa N, Seiki M, Suzuki T, et al. Critical role of transient activity of MT1-MMP for ECM degradation in invadopodia. PLoS Comput Biol. 2013;9:e1003086 pubmed publisher
    ..The present analysis and characterization of ECM degradation by MT1-MMP together with our previous report indicate a dynamic nature of MT1-MMP at invadopodia and the importance of its transient peak in the degradation of the ECM...
  63. Fuster M, Esko J. The sweet and sour of cancer: glycans as novel therapeutic targets. Nat Rev Cancer. 2005;5:526-42 pubmed
    ..Such novel agents might be used alone or in combination with operative and/or chemoradiation strategies for treating cancer...
  64. Turley E, Veiseh M, Radisky D, Bissell M. Mechanisms of disease: epithelial-mesenchymal transition--does cellular plasticity fuel neoplastic progression?. Nat Clin Pract Oncol. 2008;5:280-90 pubmed publisher
    ..We also highlight the role of RAS-controlled signaling mediators, ERK1, ERK2 and phosphatidylinositol 3-kinase, as microenvironmental responsive regulators of EMT...
  65. Lee C, Hung Y, Lin C, Hung P, Hung H, Shieh Y. Loss of SFRP1 expression is associated with aberrant beta-catenin distribution and tumor progression in mucoepidermoid carcinoma of salivary glands. Ann Surg Oncol. 2010;17:2237-46 pubmed publisher
    ..Cytoplasmic and nuclear accumulation of beta-catenin in mucoepidermoid carcinoma (MEC) is frequently noted, but the mechanism is unknown...
  66. Cao L, Liu X, Lin E, Wang C, Choi E, Riban V, et al. Environmental and genetic activation of a brain-adipocyte BDNF/leptin axis causes cancer remission and inhibition. Cell. 2010;142:52-64 pubmed publisher
    ..These results suggest that genetic or environmental activation of this BDNF/leptin axis may have therapeutic significance for cancer...
  67. Peluso J, Gawkowska A, Liu X, Shioda T, Pru J. Progesterone receptor membrane component-1 regulates the development and Cisplatin sensitivity of human ovarian tumors in athymic nude mice. Endocrinology. 2009;150:4846-54 pubmed publisher
    ..Taken together, these findings indicate that PGRMC1 plays an essential role in the development and CDDP sensitivity of human ovarian tumors...
  68. Tuhkanen H, Soini Y, Kosma V, Anttila M, Sironen R, Hamalainen K, et al. Nuclear expression of Snail1 in borderline and malignant epithelial ovarian tumours is associated with tumour progression. BMC Cancer. 2009;9:289 pubmed publisher
    ..The aim of the present study was to elucidate the expression of Snail1 protein during epithelial ovarian tumourigenesis and to study the association of Snail1 expression with clinicopathological factors and prognosis...
  69. Li Y, Li J, Liu H, Liu Y, Cui B. Expression of MYSM1 is associated with tumor progression in colorectal cancer. PLoS ONE. 2017;12:e0177235 pubmed publisher
    ..These data suggested that expression of MYSM1 was associated with the progression of CRC and might be a potential biomarker for clinical prognosis. ..
  70. Alkim C, Savas B, Ensari A, Alkim H, Dagli U, Parlak E, et al. Expression of p53, VEGF, microvessel density, and cyclin-D1 in noncancerous tissue of inflammatory bowel disease. Dig Dis Sci. 2009;54:1979-84 pubmed publisher
    ..Detecting strong p53 overexpression with VEGF overexpression may help in differentiating inflammatory bowel disease from other colitis...
  71. Goetz J, Lajoie P, Wiseman S, Nabi I. Caveolin-1 in tumor progression: the good, the bad and the ugly. Cancer Metastasis Rev. 2008;27:715-35 pubmed publisher
    ..In this review, we survey the functional roles of Cav1 in cancer and argue that Cav1 function is interdependent on tumor stage and the expression of molecular effectors that impact on its role during tumor progression...
  72. Hernandez Rodriguez N, Correa E, Contreras Paredes A, Green L. Evidence that thrombin present in lungs of patients with pulmonary metastasis may contribute to the development of the disease. Lung Cancer. 1999;26:157-67 pubmed
    ..They also suggest that thrombin may be involved in the development of PM...
  73. Lavarino C, Cheung N, Garcia I, Domenech G, de Torres C, Alaminos M, et al. Specific gene expression profiles and chromosomal abnormalities are associated with infant disseminated neuroblastoma. BMC Cancer. 2009;9:44 pubmed publisher
    ..The aim of this study was to investigate chromosomal alterations and differential gene expression amongst infant disseminated NB subgroups...
  74. McCahill L, Krouse R, Chu D, Juarez G, Uman G, Ferrell B, et al. Decision making in palliative surgery. J Am Coll Surg. 2002;195:411-22; discussion 422-3 pubmed
  75. Borgognoni L, Urso C, Vaggelli L, Brandani P, Gerlini G, Reali U. Sentinel node biopsy procedures with an analysis of recurrence patterns and prognosis in melanoma patients: technical advantages using computer-assisted gamma probe with adjustable collimation. Melanoma Res. 2004;14:311-9 pubmed
    ..3% versus 49.2%) and the 3 year disease-specific survival (92.3% versus 77.1%) (P < 0.001)...
  76. Thorlacius H, Toth E. Role of chromoendoscopy in colon cancer surveillance in inflammatory bowel disease. Inflamm Bowel Dis. 2007;13:911-7 pubmed
    ..However, the introduction of chromoendoscopy into surveillance programs requires meticulous training and further studies to compare the value of chromoendoscopy to newer endoscopic devices and techniques, such as narrow band imaging...
  77. Iwamoto K, Fujii S, Kurata A, Suzuki M, Hayashi T, Ohtsuki Y, et al. p53 mutations in tumor and non-tumor tissues of thorotrast recipients: a model for cellular selection during radiation carcinogenesis in the liver. Carcinogenesis. 1999;20:1283-91 pubmed
  78. Zhang L, Wu J. [DNA methylation: an epigenetic mechanism for tumorigenesis]. Yi Chuan. 2006;28:880-5 pubmed
    ..DNA methylation has an important role in transcriptional regulation, together with histone modification and chromatin remodeling...
  79. Bovée J, Cleton Jansen A, Rosenberg C, Taminiau A, Cornelisse C, Hogendoorn P. Molecular genetic characterization of both components of a dedifferentiated chondrosarcoma, with implications for its histogenesis. J Pathol. 1999;189:454-62 pubmed
  80. Chung J, Kim T. Integrin-dependent translational control: Implication in cancer progression. Microsc Res Tech. 2008;71:380-6 pubmed publisher
    ..This review also examines the hypothesis that integrins contribute to various aspects of cancer progression such as proliferation, survival, angiogenesis, and invasion through translational control...
  81. Al Sarraf M, Reddy M. Nasopharyngeal carcinoma. Curr Treat Options Oncol. 2002;3:21-32 pubmed
    ..Newer agents, alone or concomitant with radiotherapy, are being evaluated in these patients...
  82. Bessette D, Qiu D, Pallen C. PRL PTPs: mediators and markers of cancer progression. Cancer Metastasis Rev. 2008;27:231-52 pubmed publisher
    ..The identification of PRL substrates is key to understanding their roles in cancer progression and exploiting their potential as exciting new therapeutic targets for cancer treatment...
  83. Cui C, Hao S, Li X, Bai X, Cheng J, Shan B. [Effects of IL-18 gene transfection on the proliferation in vitro and tumorigenesis in vivo of mouse ovarian cancer cell line OVHM]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008;24:577-80 pubmed
    ..To investigate the effects of IL-18 gene transfection on proliferation, apoptosis and tumorigenesis of mouse ovarian cancer cell line OVHM...
  84. Smith J, Deane N, Dhawan P, Beauchamp R. Regulation of metastasis in colorectal adenocarcinoma: a collision between development and tumor biology. Surgery. 2008;144:353-66 pubmed publisher
  85. Weng L, Enomoto A, Ishida Takagishi M, Asai N, Takahashi M. Girding for migratory cues: roles of the Akt substrate Girdin in cancer progression and angiogenesis. Cancer Sci. 2010;101:836-42 pubmed publisher
    ..These findings suggest that Girdin and its interacting proteins are potential pharmaceutical targets for cancer therapies and pathological anigiogenesis, including tumor angiogenesis...
  86. Sun T, Du G, Zhang Y, Li J, Liu W, Wang Y. [Effect of aconiti lateralis radix praeparata and taraxaci herba on Chinese medicine signs and symptoms of urethane-induced lung cancer in mice]. Zhongguo Zhong Yao Za Zhi. 2012;37:3097-101 pubmed
    ..To study Chinese medicine (CM) signs and symptoms of urethane-induced lung cancer in mice, and observe the effect of Aconiti Lateralis Radix Praeparata and Taraxaci Herba on symptoms in mice and tumor progress...
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    ..The more recent development of PET-CT permits fusion of anatomic and functional information. Early investigations suggest that this strategy provides superior results compared to either technique alone...
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