cavernous hemangioma


Summary: A vascular anomaly that is a collection of tortuous BLOOD VESSELS and connective tissue. This tumor-like mass with the large vascular space is filled with blood and usually appears as a strawberry-like lesion in the subcutaneous areas of the face, extremities, or other regions of the body including the central nervous system.

Top Publications

  1. Naama O, Gazzaz M, Akhaddar A, Belhachmi A, Asri A, Elmostarchid B, et al. Cavernous hemangioma of the skull: 3 case reports. Surg Neurol. 2008;70:654-9 pubmed publisher
    ..7% to 1% of all bone neoplasms. The vertebral column is most often affected, followed by the skull. Calvarial cavernous hemangioma is rare, comprising about 0.2% of all benign neoplasms of the skull.
  2. Parker W, Harper J, Rivera D, Holsten S, Bowden T. Mesenteric cavernous hemangioma involving small bowel and appendix: a rare presentation of a vascular tumor. Am Surg. 2009;75:811-6 pubmed
    We report on a case of cavernous hemangioma of the small bowel mesentery. Fewer than five cases of large mesenteric cavernous hemangioma have been reported in the English literature...
  3. Nasrallah I, Hayek R, Duhaime A, Stotland M, Mamourian A. Cavernous hemangioma of the skull: surgical treatment without craniectomy. J Neurosurg Pediatr. 2009;4:575-9 pubmed publisher
    The authors report the case of a large cranial cavernous hemangioma that was treated using embolization and craniotomy with preservation of the outer cranial table. A 3-year follow-up demonstrated no recurrence...
  4. Kitzmann A, Pulido J, Ferber M, Highsmith W, Babovic Vuksanovic D. A splice-site mutation in CCM1/KRIT1 is associated with retinal and cerebral cavernous hemangioma. Ophthalmic Genet. 2006;27:157-9 pubmed
    To report a case of a unilateral retinal cavernous hemangioma associated with a novel splice-site mutation in CCM1/KRIT1.
  5. Hu D, Ran Y, Zhong X, Hu H, Yu L, Lou J, et al. Overexpressed Derlin-1 inhibits ER expansion in the endothelial cells derived from human hepatic cavernous hemangioma. J Biochem Mol Biol. 2006;39:677-85 pubmed
    ..this report, we showed that Derlin-1 was down-regulated in the endothelial cells derived from human hepatic cavernous hemangioma (CHEC) compared with other tested cells...
  6. Zhang W, Ye L, Wu L, Xin Y, Gu F, Niu J, et al. Morphologic, phenotypic and functional characteristics of endothelial cells derived from human hepatic cavernous hemangioma. J Vasc Res. 2006;43:522-32 pubmed
    ..In this study, the characteristics of cavernous hemangioma endothelial cells (CHECs) derived from the human liver were analyzed in terms of morphology, phenotype and ..
  7. Aucejo F, Ortiz W, Kelly D, Winans C, Vogt D, Eghtesad B, et al. Expanding the donor pool: safe transplantation of a cadaveric liver allograft with a 10 cm cavernous hemangioma--a case report. Liver Transpl. 2006;12:687-9 pubmed
  8. Polito E, Burroni L, Pichierri P, Loffredo A, Vattimo A. Technetium tc 99m-labeled red blood cells in the preoperative diagnosis of cavernous hemangioma and other vascular orbital tumors. Arch Ophthalmol. 2005;123:1678-83 pubmed
    To evaluate technetium Tc 99m (99mTc) red blood cell scintigraphy as a diagnostic tool for orbital cavernous hemangioma and to differentiate between orbital masses on the basis of their vascularization.
  9. Lenarz M, Durisin M, Kamenetzki P, Becker H, Kreipe H, Lenarz T. Cavernous hemangioma of the internal auditory canal. Eur Arch Otorhinolaryngol. 2007;264:569-71 pubmed
    ..about a 51-year-old male presented with right-sided sensory-neural deafness and facial nerve palsy, accompanied by severe tinnitus and ipsilateral loss of vestibular function due to a cavernous hemangioma in the internal auditory canal.

More Information


  1. Hinshaw J, Laeseke P, Weber S, Lee F. Multiple-electrode radiofrequency ablation of symptomatic hepatic cavernous hemangioma. AJR Am J Roentgenol. 2007;189:W146-9 pubmed
  2. Itshayek E, Perez Sanchez X, Cohen J, Umansky F, Spektor S. Cavernous hemangioma of the third cranial nerve: case report. Neurosurgery. 2007;61:E653; discussion E653 pubmed
    The authors report a rare case of a cavernous hemangioma (CH) involving the third cranial nerve.
  3. Higashiyama S, Kawabe J, Hayashi T, Kurooka H, Oe A, Kotani J, et al. A case of cavernous hemangioma in which malignancy was preoperatively excluded by FDG-PET. Ann Nucl Med. 2008;22:327-30 pubmed publisher
    ..Although the mass appeared to be a cavernous hemangioma, malignancy could not be ruled out...
  4. Arkadopoulos N, Kyriazi M, Yiallourou A, Stafyla V, Theodosopoulos T, Dafnios N, et al. A rare coexistence of adrenal cavernous hemangioma with extramedullar hemopoietic tissue: a case report and brief review of the literature. World J Surg Oncol. 2009;7:13 pubmed publisher
    ..Cavernous hemangiomas of the adrenal gland are rare, benign, non-functioning neoplastic tumors. To our knowledge, 55 cases have been reported in the literature to date...
  5. Virk R, Zhong J, Lu D. Diffuse cavernous hemangioma of the uterus in a pregnant woman: report of a rare case and review of literature. Arch Gynecol Obstet. 2009;279:603-5 pubmed publisher
    Diffuse cavernous hemangioma of the uterus in pregnant woman is an extremely rare condition. A total of eight cases have been described in the literature till date. The antenatal diagnosis as well as management requires considerable skill...
  6. Telem D, Nguyen S, Chin E, Weber K, Divino C. Laparoscopic resection of giant adrenal cavernous hemangioma. JSLS. 2009;13:260-2 pubmed
    ..Large adrenal tumors were initially believed to be a relative contraindication to laparoscopic adrenalectomy...
  7. Ajja A, Oukacha N, Gazzaz M, Akhaddar A, Elmostarchid B, Kadiri B, et al. Cavernous hemangioma of the parietal bone. A case report. J Neurosurg Sci. 2005;49:159-62; discussion 162 pubmed
    ..The postoperative course was uneventful. Histological study revealed a cavernous hemangioma of the diploe...
  8. Yan J, Li Y, Wu Z. Orbital cavernous hemangioma with bone erosion. Graefes Arch Clin Exp Ophthalmol. 2006;244:1534-5 pubmed
    To report a rare computed tomography (CT) feature in one case of orbital cavernous hemangioma (OCH).
  9. Chin K, Khair G, Babu P, Morgan D. Cavernous hemangioma arising from the gastro-splenic ligament: a case report. World J Gastroenterol. 2009;15:3831-3 pubmed
    ..A histological diagnosis of cavernous hemangioma arising from the gastro-splenic ligament was confirmed after laparoscopic excision and histological ..
  10. Nakamura H, Kawasaki N, Taguchi M, Kitamura H. Cavernous hemangioma of the rib diagnosed preoperatively by percutaneous needle biopsy. Gen Thorac Cardiovasc Surg. 2007;55:134-7 pubmed
    ..We emphasize the value of preoperative needle biopsy in determining the most suitable treatment for these rib tumors...
  11. Yang T, Chiang Y, Chao P, Lee F. Cavernous hemangioma of the bony external auditory canal. Otolaryngol Head Neck Surg. 2006;134:890-1 pubmed
  12. Vural M, Acikalin M, Adapinar B, Atasoy M. Congenital cavernous hemangioma of the calvaria. Case report. J Neurosurg Pediatr. 2009;3:41-5 pubmed publisher
    The authors present the case of a 6-month-old infant with a cavernous hemangioma of the parietal bone and discuss the radiological, operative, and pathological features and differential diagnosis of these extremely rare lesions in infants...
  13. Kim S, Han H, Kim J, Park J, Jeon H, Yi J. Cavernous hemangioma of the breast parenchyma with unusual features. J Ultrasound Med. 2006;25:1343-6 pubmed
  14. Melman L, Johnson F. Intramuscular cavernous hemangioma. Am J Surg. 2008;195:816-7 pubmed publisher
    ..Phleboliths on radiograph are a specific finding for cavernous hemangioma. Definitive treatment of this condition is surgical excision.
  15. Heis H, Bani Hani K, Bani Hani B. Adrenal cavernous haemangioma. Singapore Med J. 2008;49:e236-7 pubmed
    ..The risks of haemorrhage, necrosis and thrombosis impose in the majority of cases surgical excision, particularly in tumours more than 3 cm in diameter...
  16. Yamazaki A, Miyamoto H, Saito Y, Matsuzawa H, Sakao Y, Anami Y. Cavernous hemangioma of the anterior mediastinum: case report and 50-year review of Japanese cases. Jpn J Thorac Cardiovasc Surg. 2006;54:221-4 pubmed
    Hemangioma is a rare tumor of the mediastinum. We report a case of cavernous hemangioma of the anterior mediastinum that was incidentally detected by chest radiography during a routine health check...
  17. Topalak O, Gonen C, Obuz F, Secil M. Diffuse cavernous hemangioma of the rectosigmoid colon with extraintestinal involvement. Turk J Gastroenterol. 2006;17:308-12 pubmed
    b>Cavernous hemangioma of the colon is a rare cause of gastrointestinal bleeding. These lesions can be encountered as solitary, multiple, or part of a more complex syndrome with cutaneous manifestations...
  18. Peker E, Kirimi E, Tuncer O, Ceylan A, Oner A. Brachial plexus paralysis due to giant cavernous hemangioma with Kasabach-Merritt syndrome: successful management with interferon alpha. Platelets. 2009;20:603-5 pubmed publisher
    ..However, more extensive data and new patients are needed to clarify this issue...
  19. Nigri G, Bellagamba R, Giaccaglia V, Felicioni F, Aurello P, D Angelo F, et al. Minimally invasive adrenalectomy for incidentally discovered cavernous hemangioma. Minim Invasive Ther Allied Technol. 2008;17:255-8 pubmed publisher
    ..This paper reports the only case of a large cavernous hemangioma removed with transperitoneal laparoscopic adrenalectomy and reviews the literature.
  20. Minagawa T, Murata Y. [Testicular cavernous hemangioma associated with intrascrotal testicular torsion: a case report]. Hinyokika Kiyo. 2009;55:161-3 pubmed
    ..The histopathological diagnosis was testicular cavernous hemangioma. To our knowledge, only 20 cases of cavernous hemangioma of the testis have been reported to date, and this ..
  21. Quentin V, Lermite E, Lebigot J, Marinnes M, Arnaud J, Boyer J. Small bowel cavernous hemangioma: wireless capsule endoscopy diagnosis of a surgical case. Gastrointest Endosc. 2007;65:550-2 pubmed
  22. Corsi A, Ingegnoli A, Abelli P, De Chiara F, Mancini C, Cavestro G, et al. Imaging of a small bowel cavernous hemangioma: report of a case with emphasis on the use of computed tomography and enteroclysis. Acta Biomed. 2007;78:139-43 pubmed
    ..We describe a case of a jejunum cavernous hemangioma detected by computed tomography (CT) and barium studies...
  23. Nasser K, Hayashi N, Kurosaki K, Hasegawa S, Kurimoto M, Mohammed A, et al. Intraosseous cavernous hemangioma of the frontal bone. Neurol Med Chir (Tokyo). 2007;47:506-8 pubmed
    A 32-year-old man presented with a primary intraosseous cavernous hemangioma manifesting as a small painless swelling of the right forehead. Radiography revealed a radiolucent osteolytic lesion in the right frontal region...
  24. Takaoka E, Sekido N, Naoi M, Matsueda K, Kawai K, Shimazui T, et al. Cavernous hemangioma mimicking a cystic renal cell carcinoma. Int J Clin Oncol. 2008;13:166-8 pubmed publisher
    ..The pathological diagnosis was cavernous hemangioma of the left kidney...
  25. Lee S, Kwon S. Intramuscular cavernous hemangioma arising from masseter muscle: a diagnostic dilemma (2006: 12b). Eur Radiol. 2007;17:854-7 pubmed
    We report here a case of intramuscular cavernous hemangioma of the right masseter muscle in a 41-year-old woman-misdiagnosed preoperatively as parotid tumor-along with its imaging and pathologic findings...
  26. Magliulo G, Parrotto D, Sardella B, Della Rocca C, Re M. Cavernous hemangioma of the tympanic membrane and external ear canal. Am J Otolaryngol. 2007;28:180-3 pubmed
    The aims of this study are to document the occurrence of a cavernous hemangioma of the tympanic membrane (TM) and external auditory canal (EAC) that invaded the middle ear spaces and to review the relevant literature.
  27. Zhao X, Zhang J, Zhong Z, Koh C, Xie H, Hardy B. Large renal cavernous hemangioma with renal vein thrombosis: case report and review of literature. Urology. 2009;73:443.e1-3 pubmed publisher
    Kidney cavernous hemangiomas are rare. Renal cavernous hemangioma complicated by secondary chronic thrombosis of the renal vein has not been previously reported...
  28. Labauge P, Krivosic V, Denier C, Tournier Lasserve E, Gaudric A. Frequency of retinal cavernomas in 60 patients with familial cerebral cavernomas: a clinical and genetic study. Arch Ophthalmol. 2006;124:885-6 pubmed
    ..To define the frequency of retinal lesions in a large panel of patients with familial cerebral cavernomas and to screen the cerebral cavernous malformation genes in patients with cerebral and retinal lesions...
  29. Kinoshita S, Kyoda S, Tsuboi K, Son K, Usuba T, Nakasato Y, et al. Huge cavernous hemangioma arising in a male breast. Breast Cancer. 2005;12:231-3 pubmed
    We report a rare case of a huge cavernous hemangioma arising in a male breast. A 60-year-old man first noticed 1 x 2 cm elastic hard nodule just below his right nipple ten years previously. It enlarged 5 x 5 cm over six years...
  30. Ng A, Loh H, Shum C, Yip S. A case of adrenal cavernous hemangioma presenting with progressive enlargement and apparent hormonal hypersecretion. Endocr Pract. 2008;14:104-8 pubmed
    To report the case of a man with an adrenal cavernous hemangioma presenting as a progressively enlarging adrenal mass with apparent hormonal hypersecretion.
  31. Law W. Cavernous hemangioma: uncommon cause of obscure gastrointestinal bleeding. J Am Coll Surg. 2007;205:511 pubmed
  32. Sato M, Nakano M, Sasanuma M, Asari J, Watanabe K, Hanai K. [MR image of multiple intracranial cavernous angioma: the usefulness of gradient-echo MR image]. No To Shinkei. 2003;55:172-3 pubmed
  33. Forbes T. Retroperitoneal hemorrhage secondary to a ruptured cavernous hemangioma. Can J Surg. 2005;48:78-9 pubmed
  34. Yan J, Wu Z. Cavernous hemangioma of the orbit: analysis of 214 cases. Orbit. 2004;23:33-40 pubmed
    The records of all patients with orbital cavernous hemangioma managed at Zhongshan Ophthalmic Center, Sun Yat-sen University from Jan. 1, 1986 to Dec. 31, 2000 (n = 214) were reviewed retrospectively...
  35. Tekkok I, Akpinar G, Gungen Y. Extradural lumbosacral cavernous hemangioma. Eur Spine J. 2004;13:469-73 pubmed
    ..b>Cavernous hemangioma should be considered in the differential diagnosis of an enhancing extradural periradicular mass causing ..
  36. Oztekin H, Karaarslan A. [Carpal tunnel syndrome due to a cavernous hemangioma of the median nerve]. Acta Orthop Traumatol Turc. 2003;37:170-2 pubmed
    ..The mass was removed by epineural resection and the patient's complaints disappeared after a while. During a six-year follow-up no recurrences were detected...
  37. Olsen K, Stacy G, Montag A. Soft-tissue cavernous hemangioma. Radiographics. 2004;24:849-54 pubmed
  38. Maeshima E, Minami Y, Sato M, Matsuda K, Uchiyama K, Goda M, et al. A case of systemic lupus erythematosus with giant hepatic cavernous hemangioma. Lupus. 2004;13:546-8 pubmed
  39. Dourmishev L, Dourmishev A. Craniofacial cavernous hemangioma: succesful treatment with methylprednisolone. Acta Dermatovenerol Alp Pannonica Adriat. 2005;14:49-52 pubmed
    ..A 7-month-old female infant with extended cavernous hemangioma on the left part of forehead, face,and neck which appeared 15 days after birth is presented...
  40. Wang H, Tu Y, Fu C, Meng R, Cui L, Xu H, et al. Diffuse cavernous hemangioma of the rectosigmoid colon. Tech Coloproctol. 2005;9:145-8 pubmed
    Diffuse cavernous hemangioma of the rectosigmoid colon is an uncommon benign vascular lesion. We report 5 cases of diffuse cavernous hemangioma, focusing on the clinical features, diagnosis procedure and treatment...
  41. Sarraf D, Payne A, Kitchen N, Sehmi K, Downes S, Bird A. Familial cavernous hemangioma: An expanding ocular spectrum. Arch Ophthalmol. 2000;118:969-73 pubmed
    ..To describe the clinical and genetic findings in a family with multiple cases of cavernous hemangiomas...
  42. Suzuki Y, Ikeda H, Matsumoto K. Neuroradiological features of intraosseous cavernous hemangioma--case report. Neurol Med Chir (Tokyo). 2001;41:279-82 pubmed
    ..The lesion was subtotally removed. Histological examination suggested cavernous hemangioma. Preoperative examinations could not provide a definitive diagnosis, which was established by the operative ..
  43. Srivastava D, Gandhi D, Seith A, Pande G, Sahni P. Transcatheter arterial embolization in the treatment of symptomatic cavernous hemangiomas of the liver: a prospective study. Abdom Imaging. 2001;26:510-4 pubmed
    ..The technique, its complications, and effectiveness also were analyzed...
  44. Makhlouf H, Ishak K. Sclerosed hemangioma and sclerosing cavernous hemangioma of the liver: a comparative clinicopathologic and immunohistochemical study with emphasis on the role of mast cells in their histogenesis. Liver. 2002;22:70-8 pubmed
    ..Sclerosed hemangiomas of the liver are rare. To date, their histopathology, immunohistochemistry, and the role of mast cells (MC) in their histogenesis have not been systematically studied...
  45. Shimizu K, Yamashita Y, Hihara J, Seto Y, Toge T. Cavernous hemangioma of the rib. Ann Thorac Surg. 2002;74:932-4 pubmed
    ..The mass was pathologically diagnosed as cavernous hemangioma of the rib. This is the fourth case of this rare disease to be reported...
  46. Reeck J, Yen T, Szmit A, Cheung S. Cavernous hemangioma of the external ear canal. Laryngoscope. 2002;112:1750-2 pubmed
    To document the occurrence of a cavernous hemangioma of the external ear canal and to review the relevant literature. STUDY DESIGN Case report and literature review.
  47. Mesurolle B, Wexler M, Halwani F, Aldis A, Veksler A, Kao E. Cavernous hemangioma of the breast: mammographic and sonographic findings and follow-up in a patient receiving hormone-replacement therapy. J Clin Ultrasound. 2003;31:430-6 pubmed
    ..The histopathologic diagnosis was typical cavernous hemangioma. It was not excised, but HRT was discontinued...
  48. Li G, Chen Q, Jiang J, Zhao Z. The origin of blood supply for cavernous hemangioma of the liver. Hepatobiliary Pancreat Dis Int. 2003;2:367-70 pubmed
    To investigate the origin of blood supply to cavernous hemangioma of the liver (CHL).
  49. Shimoji K, Shiraishi R, Kuwatsuru A, Maehara T, Matsumoto T, Kurosaki Y. Spontaneous subacute intratumoral hemorrhage of hepatic cavernous hemangioma. Abdom Imaging. 2004;29:443-5 pubmed
    We report a case of giant hepatic cavernous hemangioma associated with spontaneous subacute intratumoral hemorrhage...
  50. Dey D, Landrum O, Oaklander A. Central neuropathic itch from spinal-cord cavernous hemangioma: a human case, a possible animal model, and hypotheses about pathogenesis. Pain. 2005;113:233-7 pubmed
    ..Study of quisqualate-injected rats may provide leads towards new treatments for neuropathic itch...
  51. Hanaoka J, Inoue S, Fujino S, Kontani K, Sawai S, Tezuka N, et al. Mediastinal cavernous hemangioma in a child: report of a case. Surg Today. 2002;32:985-8 pubmed
    We present herein a rare case of mediastinal cavernous hemangioma in a 5-year-old boy. The patient was referred to our hospital for an evaluation of cough and high fever...
  52. Padolecchia R, Acerbi G, Puglioli M, Collavoli P, Ravelli V, Caciagli P. Epidural spinal cavernous hemangioma. Spine (Phila Pa 1976). 1998;23:1136-40 pubmed
    Five cases of epidural spinal cavernous hemangioma submitted to magnetic resonance imaging and surgery were reviewed.
  53. Couteulx S, Brezin A, Fontaine B, Tournier Lasserve E, Labauge P. A novel KRIT1/CCM1 truncating mutation in a patient with cerebral and retinal cavernous angiomas. Arch Ophthalmol. 2002;120:217-8 pubmed
  54. Sayit E, Durak I, Capakaya G, Yilmaz M, Durak H. The role of Tc-99m RBC scintigraphy in the differential diagnosis of orbital cavernous hemangioma. Ann Nucl Med. 2001;15:149-51 pubmed
    The cavernous hemangioma is the most common benign orbital tumor in adults. Its presentation is during the forth to fifth decades with a slowly progressive unilateral proptosis...
  55. Tanaka A, Mihara F, Yoshiura T, Togao O, Kuwabara Y, Natori Y, et al. Differentiation of cavernous hemangioma from schwannoma of the orbit: a dynamic MRI study. AJR Am J Roentgenol. 2004;183:1799-804 pubmed
    ..The purpose of this study was to determine the capability of dynamic contrast MRI to differentiate hemangioma from schwannoma of the orbit...
  56. Demir Z, Oktem F, Celebioglu S. Rare case of intramasseteric cavernous hemangioma in a three-year-old boy: a diagnostic dilemma. Ann Otol Rhinol Laryngol. 2004;113:455-8 pubmed
    ..This case report presents a severe facial asymmetry caused by a left intramasseteric cavernous hemangioma in a 3-year-old boy. We were unaware of the exact nature of the tumor until intraoperative examination...