hemangioblastoma

Summary

Summary: A benign tumor of the nervous system that may occur sporadically or in association with VON HIPPEL-LINDAU DISEASE. It accounts for approximately 2% of intracranial tumors, arising most frequently in the cerebellar hemispheres and vermis. Histologically, the tumors are composed of multiple capillary and sinusoidal channels lined with endothelial cells and clusters of lipid-laden pseudoxanthoma cells. Usually solitary, these tumors can be multiple and may also occur in the brain stem, spinal cord, retina, and supratentorial compartment. Cerebellar hemangioblastomas usually present in the third decade with INTRACRANIAL HYPERTENSION, and ataxia. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2071-2)

Top Publications

  1. Fomekong E, Hernalsteen D, Godfraind C, D Haens J, Raftopoulos C. Pituitary stalk hemangioblastoma: the fourth case report and review of the literature. Clin Neurol Neurosurg. 2007;109:292-8 pubmed
    ..To our knowledge, this case is the only pituitary stalk HBL with total resection, and a long follow-up fully documented...
  2. Nonaka D, Rodriguez J, Rosai J. Extraneural hemangioblastoma: a report of 5 cases. Am J Surg Pathol. 2007;31:1545-51 pubmed
    b>Hemangioblastoma is a morphologically distinctive tumor that can occur sporadically or in association with von Hippel-Lindau disease, and which involves the central nervous system in the majority of the cases...
  3. Panelos J, Beltrami G, Capanna R, Franchi A. Primary capillary hemangioblastoma of bone: report of a case arising in the sacrum. Int J Surg Pathol. 2010;18:580-3 pubmed publisher
    Capillary hemangioblastoma (CHB) is a benign, highly vascularized tumor that generally occurs in the central nervous system either in the setting of von Hippel-Lindau (VHL) disease or, more often, as a solitary sporadic lesion that is ..
  4. Ertas G, Altundag M, Ucer A, Cankal F, Altundag K. Treatment of recurrent cerebellar hemangioblastoma with external radiotherapy in a patient with von Hippel-Lindau disease: a case report and review of the literature. J Neurooncol. 2005;73:273-5 pubmed
    ..We report the case of a 40-year-old man with type I von Hippel-Lindau disease treated with external radiotherapy for recurrent cerebellar hemangioblastoma.
  5. Hanse M, Vincent A, van den Bent M. Hemangioblastomatosis in a patient with von Hippel-Lindau disease. J Neurooncol. 2007;82:163-4 pubmed
  6. Shin D, Kim S, Kim K, Shin H, Yoon D. Surgical management of spinal cord haemangioblastoma. Acta Neurochir (Wien). 2008;150:215-20; discussion 220 pubmed publisher
    ..Post-operative functional status is determined by pre-operative functional status. Total removal is feasible by using the correct surgical technique and is recommended to prevent recurrence. ..
  7. Barresi V, Vitarelli E, Branca G, Antonelli M, Giangaspero F, Barresi G. Expression of brachyury in hemangioblastoma: potential use in differential diagnosis. Am J Surg Pathol. 2012;36:1052-7 pubmed publisher
    b>Hemangioblastoma (HBL) accounts for up to 2.5% of all intracranial tumors. It may occur as a sporadic entity or as a part of Von Hippel-Lindau syndrome...
  8. Slater A, Moore N, Huson S. The natural history of cerebellar hemangioblastomas in von Hippel-Lindau disease. AJNR Am J Neuroradiol. 2003;24:1570-4 pubmed
    ..In our patient population, tumors that remained solid were asymptomatic and well tolerated in the cerebellum. ..
  9. Reyns N, Assaker R, Louis E, Lejeune J. Leptomeningeal hemangioblastomatosis in a case of von Hippel-Lindau disease: case report. Neurosurgery. 2003;52:1212-5; discussion 1215-6 pubmed
    ..A 50-year-old male patient had a history of three surgical procedures for the removal of a cerebellar hemangioblastoma, initially considered to be a recurrence of a sporadic form at the same location...

More Information

Publications70

  1. Liu Y, Qiu X, Wang E. Sporadic hemangioblastoma of the kidney: a rare renal tumor. Diagn Pathol. 2012;7:49 pubmed publisher
    b>Hemangioblastoma is a benign and morphologically distinctive tumor that can occur sporadically or in association with von Hippel-Lindau disease in approximately 25% of the cases, and which involves the central nervous system in the ..
  2. Ryang Y, Oertel M, Thron A, Gilsbach J, Rohde V. Rare intramedullary hemorrhage of a brainstem hemangioblastoma. Zentralbl Neurochir. 2007;68:29-33 pubmed
    ..We report the first case of a brainstem hemorrhage due to a hemangioblastoma of the medulla oblongata.
  3. Vortmeyer A, Yuan Q, Lee Y, Zhuang Z, Oldfield E. Developmental effects of von Hippel-Lindau gene deficiency. Ann Neurol. 2004;55:721-8 pubmed
    ..To better understand hemangioblastoma histogenesis, we analyzed postmortem CNS tissues from four patients with well-established diagnosis of VHL ..
  4. Lonser R, Oldfield E. Microsurgical resection of spinal cord hemangioblastomas. Neurosurgery. 2005;57:372-6; discussion 372-6 pubmed
    ..Despite their exceptionally vascular nature, these lesions can consistently be resected completely and safely with minimal blood loss. We describe a microsurgical method for removal of these tumors from the spinal cord...
  5. Carney E, Banerjee P, Ellis C, Albadine R, Sharma R, Chaux A, et al. PAX2(-)/PAX8(-)/inhibin A(+) immunoprofile in hemangioblastoma: A helpful combination in the differential diagnosis with metastatic clear cell renal cell carcinoma to the central nervous system. Am J Surg Pathol. 2011;35:262-7 pubmed publisher
    ..We propose an immunohistochemistry (IHC) panel of combination of PAX2, PAX8, and inhibin A as a helpful approach in distinguishing the 2 lesions...
  6. Ip Y, Yuan J, Cheung H, Chan J. Sporadic hemangioblastoma of the kidney: an underrecognized pseudomalignant tumor?. Am J Surg Pathol. 2010;34:1695-700 pubmed publisher
    b>Hemangioblastoma is a benign tumor that can occur sporadically, or in association with von Hippel-Lindau disease in approximately one-quarter of the cases. Only exceptionally does it occur outside the central nervous system...
  7. Yoshida A, Oda R, Shibahara J, Fukayama M, Tsuda H. Soft-tissue hemangioblastoma of the retroperitoneum: a case study and review of the literature. Appl Immunohistochem Mol Morphol. 2010;18:479-82 pubmed publisher
    ..It was resected and showed the typical histology of hemangioblastoma, that is, numerous capillaries and stromal cells with focal cytoplasmic vacuolization...
  8. Shively S, Beltaifa S, Gehrs B, Duong H, Smith J, Edwards N, et al. Protracted haemangioblastic proliferation and differentiation in von Hippel-Lindau disease. J Pathol. 2008;216:514-20 pubmed publisher
  9. Kanno H, Yamamoto I, Nishikawa R, Matsutani M, Wakabayashi T, Yoshida J, et al. Spinal cord hemangioblastomas in von Hippel-Lindau disease. Spinal Cord. 2009;47:447-52 pubmed publisher
    ..Retrospective data analysis...
  10. Miyata S, Mikami T, Minamida Y, Akiyama Y, Houkin K. Suprasellar hemangioblastoma. J Neuroophthalmol. 2008;28:325-6 pubmed publisher
    ..The hypothalamus appeared to be the origin of the mass, which proved to be hemangioblastoma, a rare tumor in this location.
  11. Altinoz M, Santaguida C, Guiot M, Del Maestro R. Spinal hemangioblastoma containing metastatic renal cell carcinoma in von Hippel-Lindau disease. Case report and review of the literature. J Neurosurg Spine. 2005;3:495-500 pubmed
    The authors describe the case of a patient with von Hippel-Lindau (VHL) disease in which a spinal hemangioblastoma contained metastatic renal cell carcinoma (RCC)...
  12. Navas Garcia M, Pedrosa Sanchez M, Carrasco Moro R, Pascual Garvi J, Sola R. [Cystic hemangioblastoma of the junction of the medulla and upper spinal cord associated to von Hippel-Lindau disease. Two case reports and a review of the literature]. Rev Neurol. 2009;48:463-8 pubmed
    ..Only 5-20% of hemangioblastomas are located in the brainstem, and those that occur at the junction of the medulla and upper spinal cord are the ones that are less commonly diagnosed...
  13. Vortmeyer A, Tran M, Zeng W, Glasker S, Riley C, Tsokos M, et al. Evolution of VHL tumourigenesis in nerve root tissue. J Pathol. 2006;210:374-82 pubmed
    ..The evolution of frank haemangioblastoma seems to involve multiple steps from a large pool of precursor lesions...
  14. Quadery F, Okamoto K. Diffusion-weighted MRI of haemangioblastomas and other cerebellar tumours. Neuroradiology. 2003;45:212-9 pubmed
    ..The ADC was increased in haemangioblastomas. These findings may indicate rich vascular spaces of the haemangioblastomas. DWI may be useful for distinguishing haemangioblastomas from other enhancing cerebellar tumours...
  15. Deb P, Pal S, Dutta V, Srivastava A, Bhargava A, Yadav K. Adrenal haemangioblastoma presenting as phaeochromocytoma: a rare manifestation of extraneural hemangioblastoma. Endocr Pathol. 2012;23:187-90 pubmed publisher
    ..We present an unusual case of von Hippel-Lindau (VHL) disease that had adrenal and cerebellar haemangioblastoma with multiple renal cysts, and a review of the literature...
  16. Ammerman J, Lonser R, Dambrosia J, Butman J, Oldfield E. Long-term natural history of hemangioblastomas in patients with von Hippel-Lindau disease: implications for treatment. J Neurosurg. 2006;105:248-55 pubmed
  17. Temprano T, Fernandez De Leon R, Rial J, Fernandez J, Mateos V. [Cystic bulbar hemangioblastoma]. Rev Neurol. 2008;47:134-6 pubmed
    ..The first description of the disease goes back to the year 1904, when Eugene von Hippel made the description of retinal haemangioblastoma...
  18. Koh E, Nichol A, Millar B, Menard C, Pond G, Laperriere N. Role of fractionated external beam radiotherapy in hemangioblastoma of the central nervous system. Int J Radiat Oncol Biol Phys. 2007;69:1521-6 pubmed
    To assess the clinical outcomes and toxicity in patients receiving fractionated external beam radiotherapy (EBRT) for hemangioblastoma of the central nervous system, treated at two Canadian radiation oncology institutions.
  19. Akhaddar A, Ajja A, Albouzidi A, Elmostarchid B, Boucetta M. Cystic schwannoma of the cauda equina mimicking hemangioblastoma. Neurochirurgie. 2008;54:101-3 pubmed publisher
    ..Diagnosis of a tumor origin was suspected two years later on MRI as a hemangioblastoma. The lesion was histologically confirmed to be a schwannoma...
  20. Sharma G, Kucia E, Spetzler R. Spontaneous intramedullary hemorrhage of spinal hemangioblastoma: case report. Neurosurgery. 2009;65:E627-8; discussion E628 pubmed publisher
    Spontaneous hemorrhage of a spinal hemangioblastoma is a rare event. With limited reports in the literature, the risk of acute hemorrhage associated with these lesions is poorly understood.
  21. Rivera A, Takei H, Zhai J, Shen S, Ro J, Powell S. Useful immunohistochemical markers in differentiating hemangioblastoma versus metastatic renal cell carcinoma. Neuropathology. 2010;30:580-5 pubmed publisher
    ..Fli-1 failed to stain tumor cells in both HBs and RCC. Inhibin A, in combination with PAX-2, showed to be the most useful markers to differentiate HB from metastatic RCC...
  22. Barrey C, Kalamarides M, Polivka M, George B. Cervical dumbbell intra-extradural hemangioblastoma: total removal through the lateral approach: technical case report. Neurosurgery. 2005;56:E625; discussion E625 pubmed
    ..Among them, intra-extradural forms with a dumbbell extension are extremely rare. We report a case of intra-extradural hemangioblastoma involving the C6 cervical nerve root.
  23. Piribauer M, Czech T, Dieckmann K, Birner P, Hainfellner J, Prayer D, et al. Stabilization of a progressive hemangioblastoma under treatment with thalidomide. J Neurooncol. 2004;66:295-9 pubmed
    After the second recurrence of spinal seeding in hemangioblastoma not associated to von-Hippel-Lindau disease, we treated an adult female patient with thalidomide 200 mg orally/day at night for longer than 1 year...
  24. Vortmeyer A, Frank S, Jeong S, Yuan K, Ikejiri B, Lee Y, et al. Developmental arrest of angioblastic lineage initiates tumorigenesis in von Hippel-Lindau disease. Cancer Res. 2003;63:7051-5 pubmed
    ..Because of VHL deficiency, Epo receptor-expressing, developmentally arrested angioblasts simultaneously coexpress Epo, which may represent a crucial pathogenetic step in tumor formation...
  25. Wong W, Liang K, Hammel K, Coleman H, Chew E. Intravitreal ranibizumab therapy for retinal capillary hemangioblastoma related to von Hippel-Lindau disease. Ophthalmology. 2008;115:1957-64 pubmed publisher
    ..To evaluate the effect of intravitreal ranibizumab on retinal capillary hemangioblastomas (RCHs) associated with von Hippel-Lindau (VHL) disease that are not amenable or responsive to standard therapy...
  26. Wang C. Spinal hemangioblastoma: report on 68 cases. Neurol Res. 2008;30:603-9 pubmed publisher
    Rare papers focusing on spinal hemangioblastoma, especially with large clinical series, had been published before. In our hospital, there are 68 cases of spinal hemangioblastoma treated surgically...
  27. Rumboldt Z, Gnjidić Z, Talan Hranilovic J, Vrkljan M. Intrasellar hemangioblastoma: characteristic prominent vessels on MR imaging. AJR Am J Roentgenol. 2003;180:1480-1 pubmed
  28. Merrill M, Edwards N, Lonser R. Hemangioblastoma-associated mast cells in von Hippel-Lindau disease are tumor derived. Blood. 2013;121:859-60 pubmed publisher
  29. Van Velthoven V, Reinacher P, Klisch J, Neumann H, Glasker S. Treatment of intramedullary hemangioblastomas, with special attention to von Hippel-Lindau disease. Neurosurgery. 2003;53:1306-13; discussion 1313-4 pubmed
  30. Jarrell S, Vortmeyer A, Linehan W, Oldfield E, Lonser R. Metastases to hemangioblastomas in von Hippel-Lindau disease. J Neurosurg. 2006;105:256-63 pubmed
  31. Zagzag D, Krishnamachary B, Yee H, Okuyama H, Chiriboga L, Ali M, et al. Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor. Cancer Res. 2005;65:6178-88 pubmed
    ..of a single tumor suppressor gene can up-regulate the expression of both a ligand and its receptor, which may establish an autocrine signaling pathway with important roles in the pathogenesis of hemangioblastoma and CC-RCC.
  32. Glasker S, Li J, Xia J, Okamoto H, Zeng W, Lonser R, et al. Hemangioblastomas share protein expression with embryonal hemangioblast progenitor cell. Cancer Res. 2006;66:4167-72 pubmed
    ..Finally, the consistent identification of Scl in the stromal cells may help explain the unique and characteristic topographical distribution of hemangioblastomas within the CNS...
  33. Girmens J, Erginay A, Massin P, Scigalla P, Gaudric A, Richard S. Treatment of von Hippel-Lindau retinal hemangioblastoma by the vascular endothelial growth factor receptor inhibitor SU5416 is more effective for associated macular edema than for hemangioblastomas. Am J Ophthalmol. 2003;136:194-6 pubmed
    To test the efficacy of the novel vascular endothelial growth factor (VEGF) receptor inhibitor SU5416, in a case of refractory von Hippel-Lindau (VHL) retinal hemangioblastoma (RHB).
  34. Toyoda H, Seki M, Nakamura H, Inoue Y, Yamano Y, Takaoka K. Intradural extramedullary hemangioblastoma differentiated by MR images in the cervical spine: a case report and review of the literature. J Spinal Disord Tech. 2004;17:343-7 pubmed
    We report a rare case of hemangioblastoma existing in the intradural extramedullary location diagnosed by magnetic resonance imaging (MRI) examination alone. A 46-year-old man gradually developed numbness in his lower extremities...
  35. Wu T, Guo W, Lirng J, Wong T, Chang F, Luo C, et al. Spinal cord hemangioblastoma with extensive syringomyelia. J Chin Med Assoc. 2005;68:40-4 pubmed
    ..nodule at spinal cord level T10-11 with long-segment syrinx formation suggested the diagnosis of spinal hemangioblastoma with syringomyelia...
  36. Kato M, Ohe N, Okumura A, Shinoda J, Nomura A, Shuin T, et al. Hemangioblastomatosis of the central nervous system without von Hippel-Lindau disease: a case report. J Neurooncol. 2005;72:267-70 pubmed
    ..A 50-year-old woman had a history of surgical procedures for total removal of a cerebellar hemangioblastoma (HB)...
  37. Hwang S, Malek A, Schapiro R, Wu J. Intraoperative use of indocyanine green fluorescence videography for resection of a spinal cord hemangioblastoma. Neurosurgery. 2010;67:ons300-3; discussion ons303 pubmed publisher
    ..We describe a novel application of this previously defined surgical tool to assist in the resection of a residual spinal cord hemangioblastoma.
  38. Mandigo C, Ogden A, Angevine P, McCormick P. Operative management of spinal hemangioblastoma. Neurosurgery. 2009;65:1166-77 pubmed publisher
  39. Rickert C, Hasselblatt M, Jeibmann A, Paulus W. Cellular and reticular variants of hemangioblastoma differ in their cytogenetic profiles. Hum Pathol. 2006;37:1452-7 pubmed
    ..16). In conclusion, our data may point toward different genetic pathways in the pathogenesis of the 2 histologic subtypes of capillary hemangioblastoma.
  40. Myong N, Park B. Malignant glioma arising at the site of an excised cerebellar hemangioblastoma after irradiation in a von Hippel-Lindau disease patient. Yonsei Med J. 2009;50:576-81 pubmed publisher
    We describe herein a malignant glioma arising at the site of the resected hemangioblastoma after irradiation in a patient with von Hippel-Lindau disease (VHL)...
  41. Chan C, Chew E, Shen D, Hackett J, Zhuang Z. Expression of stem cells markers in ocular hemangioblastoma associated with von Hippel-Lindau (VHL) disease. Mol Vis. 2005;11:697-704 pubmed
    ..To better understand the histogenesis of ocular hemangioblastomas associated with von Hippel-Lindau (VHL) disease...
  42. Zhou J, Wang J, Li N, Zhang X, Zhou H, Zhang R, et al. Molecularly genetic analysis of von Hippel-Lindau associated central nervous system hemangioblastoma. Pathol Int. 2010;60:452-8 pubmed publisher
    ..Central nervous system hemangioblastoma (CHB) is the most common manifestation of VHL disease...
  43. Mehta G, Asthagiri A, Bakhtian K, Auh S, Oldfield E, Lonser R. Functional outcome after resection of spinal cord hemangioblastomas associated with von Hippel-Lindau disease. J Neurosurg Spine. 2010;12:233-42 pubmed publisher
  44. Utsuki S, Oka H, Sato K, Shimizu S, Suzuki S, Fujii K. Fluorescence diagnosis of tumor cells in hemangioblastoma cysts with 5-aminolevulinic acid. J Neurosurg. 2010;112:130-2 pubmed publisher
    Peritumoral hemangioblastoma cysts are usually composed of fibrous tissue without tumor cells...
  45. Hoang M, Amirkhan R. Inhibin alpha distinguishes hemangioblastoma from clear cell renal cell carcinoma. Am J Surg Pathol. 2003;27:1152-6 pubmed
    ..Two patients with von Hippel-Lindau disease had both renal cell carcinoma and hemangioblastoma. The stromal cells of all 25 cases of hemangioblastoma expressed inhibin A...
  46. Chen Y, Tachibana O, Hasegawa M, Xu R, Hamada J, Yamashita J, et al. Absence of tight junctions between microvascular endothelial cells in human cerebellar hemangioblastomas. Neurosurgery. 2006;59:660-70; discussion 660-70 pubmed
    ..The purpose of this research is to investigate the change of tight junction and its major molecular components in microvessel endothelium of human hemangioblastomas...
  47. da Costa L, de Andrade A, Braga B, Ribeiro C. Cauda equina hemangioblastoma: case report. Arq Neuropsiquiatr. 2003;61:456-8 pubmed
    ..We describe here the case of a 48 years old woman with a pure radicular hemangioblastoma, not associated with VHL, presenting with radicular pain, diagnosed with magnetic ressonance imaging (MRI) ..
  48. Karabagli H, Karabagli P, Alpman A, Durmaz B. Congenital supratentorial cystic hemangioblastoma. Case report and review of the literature. J Neurosurg. 2007;107:515-8 pubmed
    ..The histopathological diagnosis was a reticular variant of hemangioblastoma. Given that von Hippel-Lindau (VHL) gene mutations may be associated with hemangioblastomas, sequencing ..
  49. Huber T, Kouskoff V, Fehling H, Palis J, Keller G. Haemangioblast commitment is initiated in the primitive streak of the mouse embryo. Nature. 2004;432:625-30 pubmed
  50. Bostrom A, Hans F, Reinacher P, Krings T, Burgel U, Gilsbach J, et al. Intramedullary hemangioblastomas: timing of surgery, microsurgical technique and follow-up in 23 patients. Eur Spine J. 2008;17:882-6 pubmed publisher
    ..Patients without VHL most frequently require hemangioblastoma resection for diagnostic purposes and/or because symptoms prompted an imaging work-up that lead to the ..
  51. Dwarakanath S, Sharma B, Mahapatra A. Intraspinal hemangioblastoma: analysis of 22 cases. J Clin Neurosci. 2008;15:1366-9 pubmed publisher
    ..We retrospectively analyzed 22 patients who were operated on for spinal hemangioblastoma at the All India Institute of Medical Sciences, New Delhi, India...
  52. Lemeta S, Jarmalaite S, Pylkkanen L, Bohling T, Husgafvel Pursiainen K. Preferential loss of the nonimprinted allele for the ZAC1 tumor suppressor gene in human capillary hemangioblastoma. J Neuropathol Exp Neurol. 2007;66:860-7 pubmed
    ..This novel finding highlights the importance of ZAC1 in development of CHB, particularly in non-VHL-associated cases...
  53. Isobe T, Yamamoto T, Akutsu H, Anno I, Shiigai M, Zaboronok A, et al. Proton magnetic resonance spectroscopy findings of hemangioblastoma. Jpn J Radiol. 2010;28:318-21 pubmed publisher
    We report a case of proton magnetic resonance spectroscopy (MRS) of hemangioblastoma in a 56-yearold man with a history of hyperlipidemia who was suffering from an equilibrium disorder...
  54. Acikalin M, Oner U, Tel N, Pasaoglu O, Altinel F. Supratentorial hemangioblastoma: a case report and review of the literature. Arch Pathol Lab Med. 2003;127:e382-4 pubmed
    Central nervous system hemangioblastoma is a histologically benign tumor that usually occurs in the cerebellum. Supratentorial hemangioblastomas are exceedingly rare tumors...
  55. Sacko O, Bouillot Eimer S, Sesay M, Uro Coste E, Roux F, Loiseau H. Hemangioblastoma of the corpus callosum: A case report and review of the literature on its origin. Neurochirurgie. 2010;56:382-5 pubmed publisher
    A third case of corpus callosum hemangioblastoma (HB) is presented. With no preoperative embolization, surgery was uneventful and the postoperative course was excellent...
  56. Song D, Lonser R. Pathological satiety caused by brainstem hemangioblastoma. J Neurosurg Pediatr. 2008;2:397-401 pubmed publisher
    ..with abnormal early satiety resulting in growth and developmental arrest associated with a growing obex hemangioblastoma. Tumor resection resulted in restoration of appetite, with rapid weight gain, growth in stature, and onset of ..
  57. Patton K, Satcher R, Laskin W. Capillary hemangioblastoma of soft tissue: report of a case and review of the literature. Hum Pathol. 2005;36:1135-9 pubmed
    Capillary hemangioblastoma (CH) is a tumor of unknown histogenesis that arises primarily in the posterior cranial fossa, either as a sporadic event or in association with von Hippel-Lindau disease...
  58. Takai K, Taniguchi M, Takahashi H, Usui M, Saito N. Comparative analysis of spinal hemangioblastomas in sporadic disease and Von Hippel-Lindau syndrome. Neurol Med Chir (Tokyo). 2010;50:560-7 pubmed
    The clinical differences were evaluated in spinal hemangioblastoma between patients with sporadic disease and patients with von Hippel-Lindau (VHL) syndrome...
  59. Yang Y, Wang D, Jiang H, Sha C, Yuan Q, Liu J. [Treatment of spinal cord hemangioblastoma by microoperations combined with embolization]. Zhonghua Yi Xue Za Zhi. 2008;88:1309-12 pubmed
    To investigate the effects of microoperations combined with embolization in treatment of spinal cord hemangioblastoma.
  60. Huang J, Chang C, Jeng C. Surgical management of hemangioblastomas of the spinal cord. J Formos Med Assoc. 2003;102:868-75 pubmed
    ..This study analyzed the preoperative characteristics, management, and outcome in patients with successful total removal of spinal intramedullary hemangioblastomas...
  61. Takeuchi H, Hashimoto N, Kitai R, Kubota T. A report of supratentorial leptomeningeal hemangioblastoma and a literature review. Neuropathology. 2008;28:98-102 pubmed publisher
    ..Histologic examination revealed a hemangioblastoma with features resembling angiomatous meningioma...