glomus tumor

Summary

Summary: A blue-red, extremely painful vascular neoplasm involving a glomeriform arteriovenous anastomosis (glomus body), which may be found anywhere in the skin, most often in the distal portion of the fingers and toes, especially beneath the nail. It is composed of specialized pericytes (sometimes termed glomus cells), usually in single encapsulated nodular masses which may be several millimeters in diameter (From Stedman, 27th ed). CHEMODECTOMA, a tumor of NEURAL CREST origin, is also sometimes called a glomus tumor.

Top Publications

  1. Gowan R, Shamji F, Perkins D, Maziak D. Glomus tumor of the trachea. Ann Thorac Surg. 2001;72:598-600 pubmed
    Extracutaneous glomus tumors are uncommon and rarely occur in the trachea. We describe a 73-year-old man with a glomus tumor of the trachea who presented with cough, dyspnea, chest pain, and hemoptysis...
  2. De Cocker J, Messaoudi N, Waelput W, Van Schil P. Intrapulmonary glomus tumor in a young woman. Interact Cardiovasc Thorac Surg. 2008;7:1191-3 pubmed publisher
    ..Pathology showed an intrapulmonary glomus tumor of the proper type, which is a very rare occurrence...
  3. Vailati P, Bigliazzi C, Casoni G, Gurioli C, Saragoni L, Poletti V. Endoscopic removal of a right main bronchus glomus tumor. Monaldi Arch Chest Dis. 2004;61:117-9 pubmed
    ..rigid bronchoscopy to endobronchial lesions suspected to be carcinoid or other well vascularized tumours, as glomus tumor is, should be considered because it can allow a safe diagnosis and eventually be therapeutic avoiding more ..
  4. Harper L, Lavrand F, Le Bail B, Brun M, Ferron S, Oses P, et al. Glomus tumor of the mesocolon. J Pediatr Surg. 2005;40:e37-8 pubmed
    ..Intraabdominal locations are relatively rare. We report a case of glomus tumor of the mesocolon in a 10-year-old girl...
  5. Gill J, Van Vliet C. Infiltrating glomus tumor of uncertain malignant potential arising in the kidney. Hum Pathol. 2010;41:145-9 pubmed publisher
    ..These tumors rarely present in visceral organs. We report a case involving the kidney. This glomus tumor displays typical cytology and immunohistochemical profile of glomus tumors elsewhere...
  6. Zhang Y, England D. Primary pulmonary glomus tumor with contiguous spread to a peribronchial lymph node. Ann Diagn Pathol. 2003;7:245-8 pubmed
    ..The vast majority of these tumors are biologically benign. We report a case of primary pulmonary glomus tumor with atypical features characterized by mild nuclear atypia, local infiltration, and contiguous spread to a ..
  7. Debol S, Stanley M, Mallery S, Sawinski E, Bardales R. Glomus tumor of the stomach: cytologic diagnosis by endoscopic ultrasound-guided fine-needle aspiration. Diagn Cytopathol. 2003;28:316-21 pubmed
    The glomus tumor is usually a benign solitary neoplasm that arises from modified smooth muscle cells of the glomus body, a type of neuromyoarterial receptor that plays a role in the regulation of arterial blood flow...
  8. Hu X, Hu C, Fang X, Zhang T. Glomus tumor of the gastric body: helical CT findings. Chin Med J (Engl). 2007;120:1289-91 pubmed
  9. Nakajima Y, Koizumi K, Haraguchi S, Kawamoto M, Kubokura H, Okada D, et al. Locally infiltrative glomus tumor of the bronchus: a case report. Ann Thorac Cardiovasc Surg. 2010;16:113-7 pubmed
    We report a glomus tumor of the bronchus that showed invasion of the neural area and extrabronchial extension without significant histological malignancy. The patient was a male in his late 30s with the chief complaint being hemosputum...

More Information

Publications62

  1. Brouillard P, Boon L, Mulliken J, Enjolras O, Ghassibe M, Warman M, et al. Mutations in a novel factor, glomulin, are responsible for glomuvenous malformations ("glomangiomas"). Am J Hum Genet. 2002;70:866-74 pubmed
    ..The abnormal phenotype of vascular smooth-muscle cells (VSMCs) in GVMs suggests that glomulin plays an important role in differentiation of these cells--and, thereby, in vascular morphogenesis--especially in cutaneous veins...
  2. Sakr L, Palaniappan R, Payan M, Doddoli C, Dutau H. Tracheal glomus tumor: a multidisciplinary approach to management. Respir Care. 2011;56:342-6 pubmed publisher
    ..The diagnosis was benign tracheal glomus tumor. Two weeks later, elective tracheal sleeve resection with end-to-end anastomosis allowed complete resection of ..
  3. Kayal J, Hampton R, Sheehan D, Washington C. Malignant glomus tumor: a case report and review of the literature. Dermatol Surg. 2001;27:837-40 pubmed
    Glomangiosarcoma, or malignant glomus tumor, is a very rare neoplasm that when seen typically arises from a benign glomus tumor. Despite having histologic features of malignancy, these tumors usually do not metastasize...
  4. Al Ahmadie H, Yilmaz A, Olgac S, Reuter V. Glomus tumor of the kidney: a report of 3 cases involving renal parenchyma and review of the literature. Am J Surg Pathol. 2007;31:585-91 pubmed
    b>Glomus tumor is a rare mesenchymal neoplasm affecting the subcutaneous tissue of the distal extremities in the majority of cases. It only rarely involves visceral organs...
  5. Shields J, Eagle R, Shields C, Marr B. Orbital-conjunctival glomangiomas involving two ocular rectus muscles. Am J Ophthalmol. 2006;142:511-3 pubmed
    ..To report two glomangiomas in one orbit, each isolated to a rectus muscle...
  6. Panagiotopoulos E, Maraziotis T, Karageorgos A, Dimopoulos P, Koumoundourou D. A twenty-year delay in diagnosing a glomus knee tumor. Orthopedics. 2006;29:451-2 pubmed
  7. Yan S, Yeh Y, Chen C, Yang C, Kuo C, Wu H. Gastric glomus tumor: a hypervascular submucosal tumor on power Doppler endosonography. J Clin Ultrasound. 2007;35:164-8 pubmed
    ..Power Doppler imaging revealed prominent intratumoral vascular signals demonstrating its hypervascular nature. A diagnosis of glomus tumor was made via histopathologic evaluation of the resected tumor.
  8. Kapur U, Helenowski M, Zayaad A, Ghai R, Vigeneswaran W, Rajan P. Pulmonary glomus tumor. Ann Diagn Pathol. 2007;11:457-9 pubmed
    b>Glomus tumor (GT) is an infrequent but distinct neoplasm. Pulmonary GT is a rare neoplasm with only a few cases reported in the literature...
  9. Kato S, Fujii H, Yoshida A, Hinoki S. Glomus tumor beneath the plica synovialis in the knee: a case report. Knee. 2007;14:164-6 pubmed
    ..We describe a 33-year-old man with glomus tumor beneath the plica synovialis in the knee...
  10. de Bruin A, Verhoef C, Den Bakker M, van Geel A. Glomus tumor of the mesentery with atypical features: a case report. Int J Surg Pathol. 2008;16:440-2 pubmed publisher
    ..The authors present a 74-year-old woman with an exceptionally large glomus tumor of the mesentrium with malignant features...
  11. Quesada R, Gonzalez Lagunas J, Raspall G. Aggressive glomus tumor of the tongue: report of a case. Med Oral. 2004;9:350-4 pubmed
    A glomus tumor or glomangioma is a benign neoplasm originating from the modified smooth muscle cells of the vascular glomus Glomangiomas of the head and/or neck are extremely rare, with an incidence of 0.6%...
  12. Goffrini P, Ercolino T, Panizza E, Giachè V, Cavone L, Chiarugi A, et al. Functional study in a yeast model of a novel succinate dehydrogenase subunit B gene germline missense mutation (C191Y) diagnosed in a patient affected by a glomus tumor. Hum Mol Genet. 2009;18:1860-8 pubmed publisher
    ..We report a novel germline missense SDHB mutation (C191Y) in a patient affected by a glomus tumor. The missense mutation hits an amino acid residue conserved from mammals to the yeast Saccharomyces cerevisiae...
  13. Nadrous H, Allen M, Bartholmai B, Aughenbaugh G, Lewis J, Jett J. Glomus tumor of the trachea: value of multidetector computed tomographic virtual bronchoscopy. Mayo Clin Proc. 2004;79:237-40 pubmed
    b>Glomus tumor of the trachea is extremely rare. We report a case of tracheal glomus tumor in a 39-year-old man who presented with hemoptysis...
  14. Huang C, Yu F, Jan C, Yang S, Kuo Y, Hsieh J, et al. Gastric glomus tumor: a case report and review of the literature. Kaohsiung J Med Sci. 2010;26:321-6 pubmed publisher
    ..The final pathologic diagnosis was a gastric glomus tumor. We have reviewed the only five cases of gastric glomus tumors that have been reported to date in Taiwan, ..
  15. Fang H, Yang J, Zhang F, Cui Y, Han A. Clinicopathological features of gastric glomus tumor. World J Gastroenterol. 2010;16:4616-20 pubmed
    To study the clinicopathological features of gastric glomus tumor and review the related Chinese literature published in 1990-2010.
  16. Haver K, Hartnick C, Ryan D, Shailam R, Mark E. Case records of the Massachusetts General Hospital. Case 10-2008. A 10-year-old girl with dyspnea on exertion. N Engl J Med. 2008;358:1382-90 pubmed publisher
  17. Gombos Z, Zhang P. Glomus tumor. Arch Pathol Lab Med. 2008;132:1448-52 pubmed publisher
    b>Glomus tumor is a benign mesenchymal neoplasm comprising less than 2% of soft tissue tumors. It is composed of cells resembling modified smooth muscle cells of the normal glomus body...
  18. Dalfior D, Parisi A, Cannizzaro C, Bontempini L, Di Pace C, Menestrina F, et al. Pulmonary glomus tumor. Int J Surg Pathol. 2008;16:81-4 pubmed publisher
    b>Glomus tumor, also known as glomangioma, is a neoplasm derived from cells of the neuromyoarterial glomus or glomus body...
  19. Akata S, Yoshimura M, Park J, Okada S, Maehara S, Usuda J, et al. Glomus tumor of the left main bronchus. Lung Cancer. 2008;60:132-5 pubmed
    We report a case of left main bronchial glomus tumor in a 39-year-old man who presented with a cough he had had for 1 month. A computed tomography (CT) scan revealed a polypoid tumor in the membranous portion of the left main bronchus...
  20. Alam K, Maheshwari V, Sabir F, Haq M, Siddiqui F, Mefuzuddin S. Glomus tumor of lesser omentum--a case report. Indian J Pathol Microbiol. 2007;50:543-4 pubmed
    A case of glomus tumor of lesser omentum occurring in a 24 years old male is being reported for its rarity.
  21. Shang Y, Huang Y, Huang H, Bai C, Dong Y, Zhao L, et al. Removal of glomus tumor in the lower tracheal segment with a flexible bronchoscope: report of two cases. Intern Med. 2010;49:865-9 pubmed
    Tracheal glomus tumor is an extremely rare neoplasm resected mostly by open surgery or through rigid bronchoscopy...
  22. Song S, Lee C, Kim K, Lee H, Park C. Malignant glomus tumor of the stomach with multiorgan metastases: report of a case. Surg Today. 2010;40:662-7 pubmed publisher
    This report presents the case of a 65-year-old female patient with a malignant glomus tumor of the stomach, with metastases to the kidney and brain...
  23. Ravenna F, Saturni S, Casalini A, Pilato F, Pasquini C, Caramori G, et al. Bronchial glomus tumor mimicking a COPD exacerbation. Monaldi Arch Chest Dis. 2011;75:194-8 pubmed
    We report the case of a glomus tumor originating in the left main bronchus diagnosed in a 79 year old Caucasian man. A glomus tumor is an extremely rare neoplasm in the bronchi with nonspecific clinical features...
  24. Lee H, Lee J, Yang D, Lee B. A clinicopathologic study of glomus tumor of the stomach. J Clin Gastroenterol. 2006;40:717-20 pubmed
    ..Here we report a case of a 67-year-old patient in whom glomus tumor of the stomach was diagnosed after 10-day history of melena...
  25. Matsumoto K, Kakizaki H, Yagihashi N, Yagihashi S. Malignant glomus tumor in the branchial muscle of a 16-year-old girl. Pathol Int. 2001;51:729-34 pubmed
    Malignant glomus tumor is an extremely rare neoplasm and its histological features are not well characterized. We report a 16-year-old female patient with a malignant glomus tumor...
  26. Kuru I, Oktar S, Maralcan G, Yaycioglu S, Bozan M. [Familial glomus tumor encountered in the same finger and localization in four family members]. Acta Orthop Traumatol Turc. 2005;39:365-8 pubmed
    ..The tumor was surgically removed and histological examination confirmed the clinical diagnosis of a glomus tumor. Inquiry into the family history revealed that the same problem existed in the same localization with similar ..
  27. Handa U, Palta A, Mohan H, Punia R. Aspiration cytology of glomus tumor: a case report. Acta Cytol. 2001;45:1073-6 pubmed
    b>Glomus tumor is a relatively uncommon soft tissue tumor that can occur at any age and anatomic site, with a predilection for the subungual region.
  28. Lorber J, Kalish J, Farraye F, Cerda S, Babineau T. Glomus tumor of the gastric antrum: case report. Curr Surg. 2005;62:436-8 pubmed
  29. Jundi M, Lack E, Brun E, Esquivel J, Kumar D. Glomus tumor of the duodenum: a case report. Int J Surg Pathol. 2004;12:411-4 pubmed
    We describe a rare case of glomus tumor of the duodenum. The tumor was detected in a 46-year-old man being investigated for episodes of gastrointestinal bleeding. The excised specimen showed a 2.3 x 1.5 x 1...
  30. Miettinen M, Paal E, Lasota J, Sobin L. Gastrointestinal glomus tumors: a clinicopathologic, immunohistochemical, and molecular genetic study of 32 cases. Am J Surg Pathol. 2002;26:301-11 pubmed
    ..These tumors are phenotypically similar to peripheral glomus tumors and differ from epithelioid GISTs...
  31. Gu M, Nguyen P, Cao S, Lin F. Diagnosis of gastric glomus tumor by endoscopic ultrasound-guided fine needle aspiration biopsy. A case report with cytologic, histologic and immunohistochemical studies. Acta Cytol. 2002;46:560-6 pubmed
    The majority of glomus tumor are small, benign neoplasms that arise from modified smooth muscle cells. They usually occur in the dermis or subcutis of the extremities...
  32. Agawa H, Matsushita M, Nishio A, Takakuwa H. Gastric glomus tumor. Gastrointest Endosc. 2002;56:903 pubmed
  33. Ueno M, Nakashima O, Mishima M, Yamada M, Kikuno M, Nasu K, et al. Pulmonary glomus tumor: CT and MRI findings. J Thorac Imaging. 2004;19:131-4 pubmed
    Pulmonary glomus tumor is rare and its manifestations on magnetic resonance imaging (MRI) have not, to our knowledge, been reported previously. A round mass was detected in the right upper lung field on a routine chest radiograph...
  34. Kale S, Rao V, Bentz M. Glomus tumor of the index finger. J Craniofac Surg. 2006;17:801-4 pubmed
    ..Subsequent diagnostic evaluation revealed the presence of a glomus tumor. A glomus tumor is a rare tumor with a predilection for the hand...
  35. Okereke I, Sheski F, Cummings O. Glomus tumor of the trachea. J Thorac Oncol. 2011;6:1290-1 pubmed publisher
    We describe a primary glomus tumor of the trachea.
  36. Baek H, Lee S, Cho K, Choo H, Lee S, Lee Y, et al. Subungual tumors: clinicopathologic correlation with US and MR imaging findings. Radiographics. 2010;30:1621-36 pubmed publisher
    Various types of tumors can affect the subungual space, including benign solid tumors (glomus tumor, subungual exostosis, soft-tissue chondroma, keratoacanthoma, hemangioma, lobular capillary hemangioma), benign cystic lesions (epidermal ..
  37. Vassiliou I, Tympa A, Theodosopoulos T, Dafnios N, Fragulidis G, Koureas A, et al. Gastric glomus tumor: a case report. World J Surg Oncol. 2010;8:19 pubmed publisher
    ..The histopathologic examination of the specimen demonstrated a glomus tumor of the stomach...
  38. Samaniego E, Crespo A, Sanz A. [Key diagnostic features and treatment of subungual glomus tumor]. Actas Dermosifiliogr. 2009;100:875-82 pubmed
    b>Glomus tumor was first described by Wood in 1812 and named as such by Masson in 1924. It is a rare benign vascular tumor of the neuromyoarterial glomus...
  39. Chien S, Lee T, Hsu J, Wang J, Tseng H. Glomus tumor of the trachea. J Chin Med Assoc. 2003;66:551-4 pubmed
    b>Glomus tumor of the trachea is extremely rare. There were approximately 15 reported cases before. Herein, we report another case of glomus tumor of the trachea in a 50-year-old woman presenting with cough and dyspnea for 8 years...
  40. Park J, Park S, Park C. [A case of gastric glomus tumor]. Korean J Gastroenterol. 2008;52:310-4 pubmed
    b>Glomus tumor is a tumor arising from glomus body, a nodular form of arteriolovenular anastomosis that functions to regulate blood flow according to temperature...
  41. Kapur U, Hobbs C, McDermott E, Mooney E. Gastric glomus tumor. Ann Diagn Pathol. 2004;8:32-5 pubmed
    ..We describe a 3.8 cm gastric glomus tumor in a patient who also had adenocarcinoma arising in an adenoma of the rectum, and discuss the differential ..
  42. Colaut F, Toniolo L, Scapinello A, Pozzobon M. Tracheal glomus tumor successfully resected with rigid bronchoscopy: a case report. J Thorac Oncol. 2008;3:1065-7 pubmed publisher
    b>Glomus tumor of the trachea is a rare disease. A glomus tumor of the trachea in a 70-year-old man is described. The tumor was successfully excised with rigid bronchoscopy...
  43. Walsh J, Eady J. Vascular tumors. Hand Clin. 2004;20:261-8, v-vi pubmed
    ..This article reviews three basic categories of vascular tumors in the upper extremity: benign, congenital,and malignant...
  44. Tuncali D, Yilmaz A, Terzioglu A, Aslan G. Multiple occurrences of different histologic types of the glomus tumor. J Hand Surg Am. 2005;30:161-4 pubmed
    ..Two of the 3 tumors were of the same histologic type. The third tumor was a different type. Although it is rare, a solitary type of glomus tumor on initial presentation may exhibit multiple occurrences in the same patient.
  45. Liu K, Wang H, Tseng W, Shun C, Chen S, Tsang Y. Glomus tumor of the stomach: MRI findings. AJR Am J Roentgenol. 2005;185:1190-2 pubmed
  46. Clark M, O Hara C, Dobson P, Smith A. Glomus tumor and knee pain: a report of four cases. Knee. 2009;16:231-4 pubmed publisher
    ..Occasionally, local infiltration or an ischaemia test can assist with diagnosis. To our knowledge, this is the largest case series in the literature...
  47. Hishida T, Hasegawa T, Asamura H, Kusumoto M, Maeshima A, Matsuno Y, et al. Malignant glomus tumor of the lung. Pathol Int. 2003;53:632-6 pubmed
    ..We believe that this is the fourth reported case of malignant glomus tumor of the lung.
  48. Yilmaz A, Bayramgurler B, Aksoy F, Tuncer L, Selvi A, Uzman O. Pulmonary glomus tumour: a case initially diagnosed as carcinoid tumour. Respirology. 2002;7:369-71 pubmed
    ..The pathological diagnosis for the thoracotomy specimen was pulmonary glomus tumour. Follow-up chest CT was negative for recurrent tumour and the patient remains free of disease 17 months after surgery...
  49. Rallis G, Komis C, Mahera H. Glomus tumor: a rare location in the upper lip. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;98:327-36 pubmed
    b>Glomus tumor is a benign neoplasm composed of glomocytes and vessels in varying proportions. It appears as a single painful nodule typically found in the dermis and the subcutaneous tissue of the extremities...
  50. Altinok T, Cakir E, Gulhan E, Tastepe I. Tracheal glomus tumor. J Thorac Cardiovasc Surg. 2006;132:201-2 pubmed
  51. Mogi A, Kosaka T, Yamaki E, Tanaka S, Kuwano H. Successful resection of a glomus tumor of the trachea. Gen Thorac Cardiovasc Surg. 2011;59:815-8 pubmed publisher
    ..We present a case of a surgically resected glomus tumor of the trachea in a 56-year-old woman who presented with worsening dyspnea and cough...
  52. Ulivieri S, Toninelli S, Giorgio A, Fruschelli M, Miracco C, Oliveri G. Orbital glomangioma. Orbit. 2012;31:216-8 pubmed publisher
    ..Our case adds to the very few cases of orbital glomangioma reported in the literature and demonstrates that this tumor can be safely removed...
  53. Quigley J. A glomus tumor of the heel pad. A case report. J Bone Joint Surg Am. 1979;61:443-4 pubmed