veterinary venereal tumors

Summary

Alias: transmissible venereal tumors
Summary: Tumors most commonly seen on or near the genitalia. They are venereal, most likely transmitted through transplantation of cells by contact. Metastases have been reported. Spontaneous regression may occur.

Publications

  1. Stromal cells and extracellular matrix components in spontaneous canine transmissible venereal tumour at different stages of growth
    S Mukaratirwa
    Department of Pathobiology, Utrecht University
    Histol Histopathol 19:1117-23
  2. Canine transmissible venereal tumour: assessment of mast cell numbers as indicators of the growth phase
    S Mukaratirwa
    Department of Paraclinical Veterinary Studies, University of Zimbabwe, Harare, Zimbabwe
    Vet Res Commun 30:613-21
  3. Interactions of host IL-6 and IFN-gamma and cancer-derived TGF-beta1 on MHC molecule expression during tumor spontaneous regression
    Ya Wen Hsiao
    Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan, ROC
    Cancer Immunol Immunother 57:1091-104
  4. The singular history of a canine transmissible tumor
    Bridgett M VonHoldt
    Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell 126:445-7
  5. Transient downregulation of monocyte-derived dendritic-cell differentiation, function, and survival during tumoral progression and regression in an in vivo canine model of transmissible venereal tumor
    Cheng Chi Liu
    Department of Veterinary Medicine, Animal Cancer Research Center, National Taiwan University, Roosevelt Road, Section 4, 106 Taipei, Taiwan, ROC
    Cancer Immunol Immunother 57:479-91
  6. Effect of tumor infiltrating lymphocytes on the expression of MHC molecules in canine transmissible venereal tumor cells
    Ya Wen Hsiao
    Department of Veterinary Medicine, National Taiwan University, 142 Chou San Road, Taipei 106, Taiwan, ROC
    Vet Immunol Immunopathol 87:19-27
  7. Clonal origin and evolution of a transmissible cancer
    Claudio Murgia
    MRC UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 46 Cleveland Street, London W1T 4JF, UK
    Cell 126:477-87
  8. Canine transmissible venereal tumor cell depletion of B lymphocytes: molecule(s) specifically toxic for B cells
    Kuang Wen Liao
    Department of Veterinary Medicine, National Taiwan University, 142 Chou San Road, Taipei, 106, Taiwan, ROC
    Vet Immunol Immunopathol 92:149-62
  9. Cancer biology: infectious tumour cells
    David Dingli
    Nature 443:35-6
  10. Canine transmissible venereal tumour: cytogenetic origin, immunophenotype, and immunobiology. A review
    S Mukaratirwa
    University of Zimbabwe, Faculty of Veterinary Science, Department of Paraclinical Studies, Mount Pleasant, Harare
    Vet Q 25:101-11

Scientific Experts

  • S Mukaratirwa
  • A Harmelin
  • Kamran Ahrar
  • Roger J McNichols
  • T Guvenc
  • Uri Frank
  • Ya Wen Hsiao
  • Kuang Wen Liao
  • Muneeb Ahmed
  • Kuang-Wen Liao
  • Rea Min Chu
  • Rea-Min Chu
  • Ya-Wen Hsiao
  • S Nahum Goldberg
  • Jonathan B Kruskal
  • Shao Wen Hung
  • Shao-Wen Hung
  • Cheng Chi Liu
  • Sven Kurbel
  • Andrew Hines Peralta
  • R Marcos
  • Claudio Murgia
  • David Dingli
  • Bridgett M VonHoldt
  • Mi Sun Park
  • Claudia Prado de Brito
  • Noa Stettner
  • Belinda Rivera
  • D Nak
  • Clare Horkan
  • Zhengjun Liu
  • Karim S Afzal
  • Robert E Lenkinski
  • G Catone
  • S Melvyn Lobo
  • Joseph Weinstein
  • C Gobello
  • Young Ki Choi
  • Francesco Albanese
  • Mo Fan Chen
  • Chia Da Hsu
  • Ching-Yi Lin
  • Tien-Fu Chuang
  • Kwan Hwa Chi
  • Hsin Chien Chiang
  • Chen-Hsuan Liu
  • Chen Hsuan Liu
  • Tien-Fu Chung
  • Hsin-Chien Chiang
  • Tien Fu Chung
  • Ching Yi Lin
  • Kwan-Hwa Chi
  • Mo-Fan Chen
  • Yu-Shan Wang
  • Yu Shan Wang
  • Chia-Da Hsu
  • Cheng-Chi Liu
  • Tien Fu Chuang
  • Damir Vrbanec
  • Stjepko Plestina
  • Dae-yong Kim
  • Nam Shik Shin
  • Zheng jun Liu
  • Sang Yeon Oh
  • Jonathan K Pritchard
  • Marta Santos
  • Marcelo Faustino
  • Clair Motos de Oliveira
  • Sang-Yeon Oh
  • Doo Youn Cho
  • Zheng-Jun Liu
  • Min-Soo Kang
  • Doo-Youn Cho
  • Min Soo Kang
  • Stephanie Solazzo
  • Ariberto Fassati
  • Mi-Sun Park
  • Fernando Augusto Soares
  • Nam-Shik Shin
  • Andrew Hines-Peralta
  • Robin A Weiss
  • Martin A Nowak
  • C Marrinhas
  • Elaine A Ostrander
  • Su Yeon Kim
  • Dae Yong Kim
  • E Rocha
  • Yongbaek Kim
  • Roger E Price
  • Y Nak
  • John D Hazle
  • I T Cangul
  • Raya Eilam
  • B Tuna
  • Marko M Kangasniemi
  • Ori Brenner
  • Dawn Weeks
  • Michael Bennett
  • M Gramiccia
  • G Poglayen
  • A Ludovisi
  • G Marino
  • Alessandro Poli
  • Young-Ki Choi
  • Y Corrada
  • Elkan F Halpern
  • Francesca Abramo
  • S Karim Afzal
  • Chul-Joong Kim
  • G Scott Gazelle
  • Chul Joong Kim
  • Francesca Millanta
  • D Givol

Detail Information

Publications34

  1. Stromal cells and extracellular matrix components in spontaneous canine transmissible venereal tumour at different stages of growth
    S Mukaratirwa
    Department of Pathobiology, Utrecht University
    Histol Histopathol 19:1117-23
    ..001). This suggests that hyaluronan is involved in the growth of the tumour. There was no significant difference in the expression of chondroitin sulphate and versican in progressing and regressing tumours...
  2. Canine transmissible venereal tumour: assessment of mast cell numbers as indicators of the growth phase
    S Mukaratirwa
    Department of Paraclinical Veterinary Studies, University of Zimbabwe, Harare, Zimbabwe
    Vet Res Commun 30:613-21
    ....
  3. Interactions of host IL-6 and IFN-gamma and cancer-derived TGF-beta1 on MHC molecule expression during tumor spontaneous regression
    Ya Wen Hsiao
    Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan, ROC
    Cancer Immunol Immunother 57:1091-104
    ..It is suggested that the treatment of cancer cells that constitutively secrete TGF-beta1 should incorporate anti-TGF-beta activity. The findings in this in vivo tumor regression model have potential applications in cancer immunotherapy...
  4. The singular history of a canine transmissible tumor
    Bridgett M VonHoldt
    Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell 126:445-7
    ..Their findings have implications for understanding the relationship between genome instability and transmissible cancer and for conservation biology, canine genomics, and companion animal medicine...
  5. Transient downregulation of monocyte-derived dendritic-cell differentiation, function, and survival during tumoral progression and regression in an in vivo canine model of transmissible venereal tumor
    Cheng Chi Liu
    Department of Veterinary Medicine, Animal Cancer Research Center, National Taiwan University, Roosevelt Road, Section 4, 106 Taipei, Taiwan, ROC
    Cancer Immunol Immunother 57:479-91
    ..These findings provide insight into the extent of tumoral effects on host immune systems and responses. This information is useful for developing cancer immunotherapies...
  6. Effect of tumor infiltrating lymphocytes on the expression of MHC molecules in canine transmissible venereal tumor cells
    Ya Wen Hsiao
    Department of Veterinary Medicine, National Taiwan University, 142 Chou San Road, Taipei 106, Taiwan, ROC
    Vet Immunol Immunopathol 87:19-27
    ..This caused the tumor to enter R phase and helped stop CTVT growth. Our findings will facilitate the understanding and further investigation of the mechanisms that initiate host immune surveillance against tumors...
  7. Clonal origin and evolution of a transmissible cancer
    Claudio Murgia
    MRC UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 46 Cleveland Street, London W1T 4JF, UK
    Cell 126:477-87
    ..Our findings have implications for understanding genome instability in cancer, natural transplantation of allografts, and the capacity of a somatic cell to evolve into a transmissible parasite...
  8. Canine transmissible venereal tumor cell depletion of B lymphocytes: molecule(s) specifically toxic for B cells
    Kuang Wen Liao
    Department of Veterinary Medicine, National Taiwan University, 142 Chou San Road, Taipei, 106, Taiwan, ROC
    Vet Immunol Immunopathol 92:149-62
    ..The molecular weight of the CTVT-derived cytotoxic molecule(s) was 30-100kDa. Human, domestic cat, horse and mouse B cells were also sensitive to the substance...
  9. Cancer biology: infectious tumour cells
    David Dingli
    Nature 443:35-6
  10. Canine transmissible venereal tumour: cytogenetic origin, immunophenotype, and immunobiology. A review
    S Mukaratirwa
    University of Zimbabwe, Faculty of Veterinary Science, Department of Paraclinical Studies, Mount Pleasant, Harare
    Vet Q 25:101-11
    ..This review examines the current state of knowledge of the aspects of the cytogenetic origin, immunophenotype, immunobiology and immunotherapy of CTVT...
  11. Lack of MHC expression and retention of ultrastructural characteristics by xenograft transmissible venereal tumor cells in SCID mice
    A Harmelin
    Department of Veterinary Resources, The Weizmann Institute of Science, Rehobot 76100, Israel
    Vet Immunol Immunopathol 86:245-9
    ..J. Vet. Res. 62 (2001) 907]. In this paper, we demonstrate that XTVT cells maintain ultrastructural characteristics of CTVT and do not express MHC classes I and II molecules...
  12. Canine transmissible venereal tumor: a large-animal transplantable tumor model
    Belinda Rivera
    Department of Imaging Physics, The University of Texas M D Anderson Cancer Center Houston, Texas 77030 4009, USA
    Comp Med 55:335-43
    ....
  13. A Clinico-pathological study on the effect of vincristine on transmissible venereal tumour in dogs
    D Nak
    Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, University of Uludag, Bursa, Turkey
    J Vet Med A Physiol Pathol Clin Med 52:366-70
    ..66); in one dog, granulation tissue was detected in the surgery site after 2 months. Treatment success could easily be followed by the cytological changes. In conclusion, vincristine was found to be effective chemotherapeutic agent...
  14. Cutaneous transmissible venereal tumor without genital involvement in a prepubertal female dog
    R Marcos
    Cytology Diagnostic Services, Laboratory of Histology and Embryology, Institute of Biomedical Sciences Abel Salazar, University of Porto, Portugal
    Vet Clin Pathol 35:106-9
    ..Despite the atypical clinical presentation, response to chemotherapy with vincristine was excellent, leading to complete regression of the neoplasm without relapse after 6 months...
  15. Pegylated liposomal doxorubicin as a chemotherapeutic agent for treatment of canine transmissible venereal tumor in murine models
    Noa Stettner
    Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel
    J Vet Med Sci 67:1133-9
    ..In untreated CD1-nu mice, tumor progress was slower than in NOD/SCID. Our results indicate that Doxil is effective against CTVT in mouse xenograft models...
  16. Disseminated transmissible venereal tumor in a dog
    Mi Sun Park
    Department of Veterinary Pathology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Korea
    J Vet Diagn Invest 18:130-3
    ..In this case, the polymerase chain reaction technique was useful in differential diagnosis of canine round cell tumors because this technique can be applied in retrospective as well as future study...
  17. Immunohistochemical determination of estrogen receptor-alpha in vaginal and tumor tissues of healthy and TVT-affected bitches and their relation to serum concentrations of estradiol-17beta and progesterone
    Claudia Prado de Brito
    Department of Animal Reproduction, Faculty of Veterinary Medicine, University of São Paulo, Av Prof Orlando Marques de Paiva, 87, Cidade Universitária, São Paulo, SP, Brazil 05508 000
    Theriogenology 66:1587-92
    ..In conclusion, vaginal tissue of tumor and control bitches, under different distinct steroid influences, had different ER-alpha expression, whereas ER-alpha expression was not present in neoplastic tissues...
  18. Sequence analysis of canine LINE-1 elements and p53 gene in canine transmissible venereal tumor
    Young Ki Choi
    Department of Clinical and Population Sciences College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA
    J Vet Sci 3:285-92
    ..We identified the point mutation of 964 nucleotide (T-C) resulting in the change of amino acid (Phe-Ser) of p53 tumor suppressor protein...
  19. Activation of oncogenes by transposable elements
    D Givol
    Biochem Soc Symp 51:183-96
    ..8 kilobase pair cellular DNA. Nucleotide sequence analysis demonstrated that the inserted piece is 60% homologous to the monkey KpnI element which is a representative of the LINE group...
  20. Image-guided percutaneous chemical and radiofrequency tumor ablation in an animal model
    Muneeb Ahmed
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    J Vasc Interv Radiol 14:1045-52
    ....
  21. Mitosis and apoptosis in canine cutaneous histiocytoma and transmissible venereal tumour
    T Guvenc
    Pathology Department, Veterinary Medicine Faculty, Ankara University, 06110 Diskapi, Ankara, Turkey
    Acta Vet Hung 50:315-21
    ..359 (+/- 0.330) and -0.232 (+/- 0.344), respectively. No significant (P > 0.05) correlation was found between mitosis and apoptosis in these two tumour types...
  22. Primary cutaneous extragenital canine transmissible venereal tumour with Leishmania-laden neoplastic cells: a further suggestion of histiocytic origin?
    Francesco Albanese
    Practitioner, Naples, Italy
    Vet Dermatol 13:243-6
    ..Leishmania amastigotes were detected in the cytoplasm of macrophages and neoplastic cells of the tumoral mass. The presence of the parasite within neoplastic cells is consistent with a histiocytic origin of TVT...
  23. Canine transmissible venereal tumour parasitized by Leishmania infantum
    G Catone
    Dipartimento di Chirurgia, Fisiopatologia e Clinica della Riproduzione degli Animali domestici, Polo Universitario Annunziata, 98168 Messina, Italy
    Vet Res Commun 27:549-53
  24. Occurrence of the acquired immunity in early vertebrates due to danger of transmissible cancers similar to canine venereal tumors
    Sven Kurbel
    Med Hypotheses 68:1185-6
  25. The evolution of a malignant dog
    Uri Frank
    Department of Zoology, Martin Ryan Marine Science Institute, National University of Ireland, Galway, University Road, Galway, Ireland
    Evol Dev 9:521-2
  26. Tumor-infiltrating lymphocyte secretion of IL-6 antagonizes tumor-derived TGF-beta 1 and restores the lymphokine-activated killing activity
    Ya Wen Hsiao
    Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
    J Immunol 172:1508-14
    ..This new mechanism, in which TIL manufacture high concentrations of IL-6 to block tumor TGF-beta1 anti-LAK activity, has potential applications in cancer immunotherapy and tumor prognosis...
  27. Improved coagulation with saline solution pretreatment during radiofrequency tumor ablation in a canine model
    Muneeb Ahmed
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Vasc Interv Radiol 13:717-24
    ..The complete destruction of tumors 5 cm in diameter or larger suggests that this substantial increase may be achieved for tumor ablation in clinical practice...
  28. Chemical tumor ablation with use of a novel multiple-tine infusion system in a canine sarcoma model
    Andrew Hines Peralta
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Vasc Interv Radiol 17:351-8
    ....
  29. Radiofrequency ablation: effect of surrounding tissue composition on coagulation necrosis in a canine tumor model
    Muneeb Ahmed
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
    Radiology 230:761-7
    ..Predominance of tissue-specific characteristics will likely result in site-specific differences in RF-induced coagulation necrosis...
  30. Development of a large animal model for lung tumors
    Kamran Ahrar
    University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 325, Houston, Texas 77030, USA
    J Vasc Interv Radiol 13:923-8
    ..In addition, cyclosporin administration may be necessary to promote growth of viable tumor...
  31. Effects of vincristine treatment on semen quality in a dog with a transmissible venereal tumour
    C Gobello
    Institute of Theriogenology, National University of La Plata, Argentina
    J Small Anim Pract 43:416-7
    ..Total sperm count decreased to abnormally low values during weeks 4 and 5, and then began to increase up to pretreatment values. No significant alterations in the other semen parameters were found during the study period...
  32. Technical developments for cerebral thermal treatment: water-cooled diffusing laser fibre tips and temperature-sensitive MRI using intersecting image planes
    R J McNichols
    Department of Imaging Physics, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Int J Hyperthermia 20:45-56
    ..Two-plane MRTI enhances on-line monitoring and feedback of thermal treatment...