vaginal neoplasms

Summary

Summary: Tumors or cancer of the VAGINA.

Top Publications

  1. Hegemann S, Schäfer U, Lelle R, Willich N, Micke O. Long-term results of radiotherapy in primary carcinoma of the vagina. Strahlenther Onkol. 2009;185:184-9 pubmed publisher
    ..The long-term results of radiotherapy in primary carcinoma of the vagina are not well defined...
  2. Benedetti Panici P, Manci N, Bellati F, Di Donato V, Marchetti C, De Falco C, et al. Vaginectomy: a minimally invasive treatment for cervical cancer vaginal recurrence. Int J Gynecol Cancer. 2009;19:1625-31 pubmed publisher
    ..In carefully selected patients, vaginectomy may be considered a therapeutic option for IVR. Older patients with long disease-free interval and small recurrences benefit the most from this bladder-sparing surgical technique. ..
  3. Jang W, Wu H, Ha S, Kim H, Kang S, Song Y, et al. Definitive radiotherapy for treatment of primary vaginal cancer: effectiveness and prognostic factors. Int J Gynecol Cancer. 2012;22:521-7 pubmed publisher
    ..This study was performed to evaluate treatment outcomes and define prognostic factors for primary vaginal cancer treated with definitive radiotherapy...
  4. Fuste V, del Pino M, Perez A, Garcia A, Torne A, Pahisa J, et al. Primary squamous cell carcinoma of the vagina: human papillomavirus detection, p16(INK4A) overexpression and clinicopathological correlations. Histopathology. 2010;57:907-16 pubmed publisher
    ..To determine the role of human papillomavirus (HPV) in the pathogenesis of primary squamous cell carcinoma of the vagina (SCCVa), and to evaluate its clinicopathological significance...
  5. Alonso I, Felix A, Torne A, Fuste V, del Pino M, Castillo P, et al. Human papillomavirus as a favorable prognostic biomarker in squamous cell carcinomas of the vagina. Gynecol Oncol. 2012;125:194-9 pubmed publisher
    ..The aim of our study was to evaluate whether HPV status has prognostic significance in this neoplasm...
  6. Smith J, Backes D, Hoots B, Kurman R, Pimenta J. Human papillomavirus type-distribution in vulvar and vaginal cancers and their associated precursors. Obstet Gynecol. 2009;113:917-24 pubmed publisher
    ..Our aim was to conduct a systematic review of HPV type distribution in vulvar and vaginal invasive carcinomas, vulvar intraepithelial neoplasia (VIN), and vaginal intraepithelial neoplasia...
  7. Verloop J, van Leeuwen F, Helmerhorst T, van Boven H, Rookus M. Cancer risk in DES daughters. Cancer Causes Control. 2010;21:999-1007 pubmed publisher
    ..We examined long-term risk of cancer in women exposed to diethylstilbestrol (DES) in utero...
  8. De Vuyst H, Clifford G, Nascimento M, Madeleine M, Franceschi S. Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a meta-analysis. Int J Cancer. 2009;124:1626-36 pubmed publisher
    ..This proportion would be similar for the corresponding high-grade lesions of the vagina and anus, but higher for VIN2/3 (75%) than for vulvar carcinoma...
  9. Brunner A, Grimm C, Polterauer S, Hefler L, Stani J, Heinze G, et al. The prognostic role of human papillomavirus in patients with vaginal cancer. Int J Gynecol Cancer. 2011;21:923-9 pubmed publisher
    ..004) and overall survival (P=0.023). Human papillomavirus infection was frequently detected in squamous cell carcinoma of the vagina, and its presence may serve as a prognostic indicator in advanced stages. ..

More Information

Publications63

  1. Beriwal S, Demanes D, Erickson B, Jones E, De Los Santos J, Cormack R, et al. American Brachytherapy Society consensus guidelines for interstitial brachytherapy for vaginal cancer. Brachytherapy. 2012;11:68-75 pubmed publisher
    ..To present recommendations for the use of interstitial brachytherapy in patients with vaginal cancer or recurrent endometrial cancer in the vagina...
  2. Ferreira M, Crespo M, Martins L, Felix A. HPV DNA detection and genotyping in 21 cases of primary invasive squamous cell carcinoma of the vagina. Mod Pathol. 2008;21:968-72 pubmed publisher
    ..All studied histological subtypes are strongly associated with human papilloma virus infection...
  3. Larsson G, Helenius G, Andersson S, Sorbe B, Karlsson M. Prognostic impact of human papilloma virus (HPV) genotyping and HPV-16 subtyping in vaginal carcinoma. Gynecol Oncol. 2013;129:406-11 pubmed publisher
    ..The objectives of this study are to investigate the human papilloma virus (HPV) distribution in vaginal cancer and to evaluate HPV-genotype as well as HPV16-variant impact on prognosis...
  4. Wu X, Matanoski G, Chen V, Saraiya M, Coughlin S, King J, et al. Descriptive epidemiology of vaginal cancer incidence and survival by race, ethnicity, and age in the United States. Cancer. 2008;113:2873-82 pubmed publisher
    ..It has many of the same risk factors as cervical cancer, including a strong association with persistent human papillomavirus infection. Descriptive studies of the epidemiology of vaginal cancer are scarce in the literature...
  5. Shah C, Goff B, Lowe K, Peters W, Li C. Factors affecting risk of mortality in women with vaginal cancer. Obstet Gynecol. 2009;113:1038-45 pubmed publisher
    ..To estimate the current effect of demographics, pathology, and treatment on mortality among women with vaginal cancer...
  6. Insinga R, Liaw K, Johnson L, Madeleine M. A systematic review of the prevalence and attribution of human papillomavirus types among cervical, vaginal, and vulvar precancers and cancers in the United States. Cancer Epidemiol Biomarkers Prev. 2008;17:1611-22 pubmed publisher
    ..To describe prevalence and estimated attribution of human papillomavirus (HPV) types in U.S. cervical, vaginal, and vulvar precancers and cancers...
  7. Hu D, Goldie S. The economic burden of noncervical human papillomavirus disease in the United States. Am J Obstet Gynecol. 2008;198:500.e1-7 pubmed publisher
  8. McCredie M, Sharples K, Paul C, Baranyai J, Medley G, Jones R, et al. Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study. Lancet Oncol. 2008;9:425-34 pubmed publisher
    ..We aimed to estimate the long-term risk of invasive cancer in these two groups of women. A judicial inquiry referred for independent clinical review in 1988 all women for whom there remained doubt about the adequacy of their management...
  9. Hellman K, Johansson H, Andersson S, Pettersson F, Auer G. Prognostic significance of cell cycle- and invasion-related molecular markers and genomic instability in primary carcinoma of the vagina. Int J Gynecol Cancer. 2013;23:41-51 pubmed publisher
    ..Overexpression of p53 was associated with short-term survival, but the only independent predictors of survival were age at diagnosis and tumor size. ..
  10. Geisler J, Orr C, Manahan K. Robotically-assisted laparoscopic radical parametrectomy and radical vaginectomy. Eur J Gynaecol Oncol. 2011;32:674-6 pubmed
    ..A similar operation, radical vaginectomy, is rarely performed because of the its technical difficulty in getting adequate margins without an attached uterus...
  11. Dillner J, Kjaer S, Wheeler C, Sigurdsson K, Iversen O, Hernandez Avila M, et al. Four year efficacy of prophylactic human papillomavirus quadrivalent vaccine against low grade cervical, vulvar, and vaginal intraepithelial neoplasia and anogenital warts: randomised controlled trial. BMJ. 2010;341:c3493 pubmed publisher
    ..To evaluate the prophylactic efficacy of the human papillomavirus (HPV) quadrivalent vaccine in preventing low grade cervical, vulvar, and vaginal intraepithelial neoplasias and anogenital warts (condyloma acuminata)...
  12. Chaturvedi A, Madeleine M, Biggar R, Engels E. Risk of human papillomavirus-associated cancers among persons with AIDS. J Natl Cancer Inst. 2009;101:1120-30 pubmed publisher
  13. Mock U, Kucera H, Fellner C, Knocke T, Potter R. High-dose-rate (HDR) brachytherapy with or without external beam radiotherapy in the treatment of primary vaginal carcinoma: long-term results and side effects. Int J Radiat Oncol Biol Phys. 2003;56:950-7 pubmed
    ..Chronic side effects G 1-4 were observed in <or=2% (bladder, rectum) and 1%-6% (vagina). In the treatment of primary vaginal carcinoma, HDR brachytherapy appeared to be well-tolerated and as effective as LDR brachytherapy techniques. ..
  14. Allard J, McBroom J, Zahn C, McLeod D, Maxwell G. Vaginal metastasis and thrombocytopenia from renal cell carcinoma. Gynecol Oncol. 2004;92:970-3 pubmed
    ..Vaginal cancer represents approximately 1-2% of genital tract malignancies. Most cases represent metastasis from the cervix, endometrium, or colon. Metastasis of renal cell carcinoma to the vagina is extremely rare...
  15. van Dam P, Sonnemans H, van Dam P, Smet D, Verkinderen L, Dirix L. Sentinel node detection in a patient with recurrent endometrial cancer initially treated by hysterectomy and radiotherapy. Int J Gynecol Cancer. 2004;14:673-6 pubmed
    ..This unique case shows that sentinel node detection is possible after previous radiotherapy and surgery and hopes to stimulate further research in this field...
  16. Craddock K, Bandarchi B, Khalifa M. Blue nevi of the Müllerian tract: case series and review of the literature. J Low Genit Tract Dis. 2007;11:284-9 pubmed
    ..Because of their rarity (3 previous cases in the literature), vaginal blue nevi have not previously been studied with immunohistochemical and ultrastructural analysis...
  17. Hellman K, Silfversward C, Nilsson B, Hellström A, Frankendal B, Pettersson F. Primary carcinoma of the vagina: factors influencing the age at diagnosis. The Radiumhemmet series 1956-96. Int J Gynecol Cancer. 2004;14:491-501 pubmed
    ..However, in the most common age group, the older patients, there might be another (probably non-HPV-related) etiology associated with hormonal factors and trauma to the vagina...
  18. Itami J, Hara R, Kozuka T, Yamashita H, Nakajima K, Shibata K, et al. Transperineal high-dose-rate interstitial radiation therapy in the management of gynecologic malignancies. Strahlenther Onkol. 2003;179:737-41 pubmed
    ..Clinical experience in high-dose-rate interstitial radiation therapy was retrospectively investigated...
  19. Daling J, Madeleine M, Schwartz S, Shera K, Carter J, McKnight B, et al. A population-based study of squamous cell vaginal cancer: HPV and cofactors. Gynecol Oncol. 2002;84:263-70 pubmed
    ..We conducted a study to evaluate risk factors for in situ and invasive vaginal cancer and their potential relationship to prior exposure to human papillomaviruses (HPV)...
  20. Seeger A, Windschall A, Lotter M, Mehlhorn G, Beckmann M, Sauer R, et al. The role of interstitial brachytherapy in the treatment of vaginal and vulvar malignancies. Strahlenther Onkol. 2006;182:142-8 pubmed
    ..Irradiation has established itself as a treatment for vulvar and vaginal malignancies. Due to the sensitive nature of the vulvar and vaginal tissues, interstitial brachytherapy (iBT) provides an effective, gentle and individualized therapy...
  21. Hatch E, Herbst A, Hoover R, Noller K, Adam E, Kaufman R, et al. Incidence of squamous neoplasia of the cervix and vagina in women exposed prenatally to diethylstilbestrol (United States). Cancer Causes Control. 2001;12:837-45 pubmed
    ..The purpose of the current study was to evaluate the long-term risk of developing high-grade squamous neoplasia of the genital tract among women exposed prenatally to DES...
  22. Liang Z, Xu H, Chen Y, Li Y, Chang Q, Shi C. Laparoscopic radical trachelectomy or parametrectomy and pelvic and para-aortic lymphadenectomy for cervical or vaginal stump carcinoma: report of six cases. Int J Gynecol Cancer. 2006;16:1713-6 pubmed
    ..8 days. There was no intraoperative or postoperative complication. Laparoscopic radical parametrectomy with pelvic and para-aortic lymphadenectomy for cervical or vaginal stump carcinoma can be successfully and safely accomplished...
  23. Viswanathan A, Cormack R, Holloway C, Tanaka C, O Farrell D, Devlin P, et al. Magnetic resonance-guided interstitial therapy for vaginal recurrence of endometrial cancer. Int J Radiat Oncol Biol Phys. 2006;66:91-9 pubmed
    ..To evaluate the feasibility and to describe the acute toxicity of a real-time intraoperative magnetic resonance (MR)-image guided interstitial approach to treating vaginal recurrence of endometrial cancer...
  24. Strander B, Andersson Ellstrom A, Milsom I, Sparen P. Long term risk of invasive cancer after treatment for cervical intraepithelial neoplasia grade 3: population based cohort study. BMJ. 2007;335:1077 pubmed
    ..To study the long term risk of invasive cancer of the cervix or vagina after treatment for cervical intraepithelial neoplasia grade 3...
  25. Hampl M, Sarajuuri H, Wentzensen N, Bender H, Kueppers V. Effect of human papillomavirus vaccines on vulvar, vaginal, and anal intraepithelial lesions and vulvar cancer. Obstet Gynecol. 2006;108:1361-8 pubmed
    ..We assessed the prevalence of HPV (and the types) to estimate the possible effect of a HPV vaccine on lower genital tract disease prevention...
  26. Diakomanolis E, Rodolakis A, Boulgaris Z, Blachos G, Michalas S. Treatment of vaginal intraepithelial neoplasia with laser ablation and upper vaginectomy. Gynecol Obstet Invest. 2002;54:17-20 pubmed
  27. Nag S, Yacoub S, Copeland L, Fowler J. Interstitial brachytherapy for salvage treatment of vaginal recurrences in previously unirradiated endometrial cancer patients. Int J Radiat Oncol Biol Phys. 2002;54:1153-9 pubmed
    ..To evaluate whether interstitial brachytherapy can effectively salvage vaginal recurrence from endometrial carcinoma...
  28. Hellman K, Alaiya A, Schedvins K, Steinberg W, Hellström A, Auer G. Protein expression patterns in primary carcinoma of the vagina. Br J Cancer. 2004;91:319-26 pubmed
    ..There might, further, be a possibility to identify tumour-specific markers among the proteins that are differentially expressed. The results from this study have to be confirmed by more comprehensive studies in the future...
  29. Swan S. Intrauterine exposure to diethylstilbestrol: long-term effects in humans. APMIS. 2000;108:793-804 pubmed
    ..The importance of dose and gestational age at initial exposure are discussed, and the implications of DES findings for the evaluation of risks from current EDCs emphasized...
  30. Abramova L, Parekh J, Irvin W, Rice L, Taylor P, Anderson W, et al. Sentinel node biopsy in vulvar and vaginal melanoma: presentation of six cases and a literature review. Ann Surg Oncol. 2002;9:840-6 pubmed
    ..However, prophylactic lymphadenectomy has not been shown to improve survival of melanoma patients. We wanted to determine the feasibility of sentinel lymph node biopsy in patients with female urogenital melanoma as a staging procedure...
  31. Koyamatsu Y, Yokoyama M, Nakao Y, Fukuda K, Saito T, Matsukuma K, et al. A comparative analysis of human papillomavirus types 16 and 18 and expression of p53 gene and Ki-67 in cervical, vaginal, and vulvar carcinomas. Gynecol Oncol. 2003;90:547-51 pubmed
    ..This study aimed to investigate the correlation between HPV positivity, p53 overexpression, and cell proliferative activity in cervical, vaginal, and vulvar squamous cell carcinoma...
  32. Hellman K, Lundell M, Silfversward C, Nilsson B, Hellström A, Frankendal B. Clinical and histopathologic factors related to prognosis in primary squamous cell carcinoma of the vagina. Int J Gynecol Cancer. 2006;16:1201-11 pubmed
    ..Increased knowledge concerning complementary biologic markers to discriminate between low- and high malignant tumors is however of great importance...
  33. Mahdavi A, Shamshirsaz A, Peiretti M, Zakashansky K, Idrees M, Nezhat F. Laparoscopic management of vaginal clear cell adenocarcinoma arising in pelvic endometriosis: case report and literature review. J Minim Invasive Gynecol. 2006;13:237-41 pubmed
    ..She was treated with neoadjuvant chemoradiation, laparoscopically assisted radical vaginal hysterectomy, radical upper vaginectomy, and pelvic lymphadenectomy followed by combination chemotherapy...
  34. Frank S, Jhingran A, Levenback C, Eifel P. Definitive radiation therapy for squamous cell carcinoma of the vagina. Int J Radiat Oncol Biol Phys. 2005;62:138-47 pubmed
    ..To evaluate outcome and describe clinical treatment guidelines for patients with primary squamous cell carcinoma of the vagina treated with definitive radiation therapy...
  35. Indermaur M, Martino M, Fiorica J, Roberts W, Hoffman M. Upper vaginectomy for the treatment of vaginal intraepithelial neoplasia. Am J Obstet Gynecol. 2005;193:577-80; discussion 580-1 pubmed
    ..The purpose of this study was to evaluate the use of upper vaginectomy for the treatment of vaginal intraepithelial neoplasia (VAIN)...
  36. Köhler C, Tozzi R, Klemm P, Schneider A. "Schauta sine utero": technique and results of laparoscopic-vaginal radical parametrectomy. Gynecol Oncol. 2003;91:359-68 pubmed
    ..We evaluated whether radical parametrectomy without or with cervical stump exstirpation can be performed by a combined laparoscopic-vaginal approach...
  37. Nigogosyan G, DELAPAVA S, Pickren J. MELANOBLASTS IN VAGINAL MUCOSA. ORIGIN FOR PRIMARY MALIGNANT MELANOMA. Cancer. 1964;17:912-3 pubmed
  38. Petignat P, Jolicoeur M, Alobaid A, Drouin P, Gauthier P, Provencher D, et al. Salvage treatment with high-dose-rate brachytherapy for isolated vaginal endometrial cancer recurrence. Gynecol Oncol. 2006;101:445-9 pubmed
    ..To evaluate the outcome of patients with recurrent vaginal endometrial cancer treated with high-dose-rate brachytherapy (HDRB) and external beam radiation therapy (EBRT)...
  39. Mendese G, Ayvazian P, Li C. Renal cell carcinoma presenting as a perineal mass: case report and review of the literature. Urology. 2006;67:847.e1-2 pubmed
    ..This case illustrates the variability in RCC presentation. Also, because vaginal clear cell carcinoma is rare, all such lesions should be considered potentially renal in origin...
  40. Beriwal S, Bhatnagar A, Heron D, Selvaraj R, Mogus R, Kim H, et al. High-dose-rate interstitial brachytherapy for gynecologic malignancies. Brachytherapy. 2006;5:218-22 pubmed
    ..The study aimed to assess the outcome of locally advanced cervical and vaginal cancer treated with high-dose-rate interstitial brachytherapy (HDRB)...
  41. Jhingran A, Burke T, Eifel P. Definitive radiotherapy for patients with isolated vaginal recurrence of endometrial carcinoma after hysterectomy. Int J Radiat Oncol Biol Phys. 2003;56:1366-72 pubmed
    ..To determine the outcome of patients after radical radiotherapy (RT) for isolated vaginal recurrence of endometrial carcinoma and to determine the clinical and pathologic predictors of outcome...
  42. Nag S, Erickson B, Parikh S, Gupta N, Varia M, Glasgow G. The American Brachytherapy Society recommendations for high-dose-rate brachytherapy for carcinoma of the endometrium. Int J Radiat Oncol Biol Phys. 2000;48:779-90 pubmed
    ..To develop recommendations for use of high-dose-rate (HDR) brachytherapy in patients with endometrial cancer...
  43. Habermann J, Hellman K, Freitag S, Heselmeyer Haddad K, Hellström A, Shah K, et al. A recurrent gain of chromosome arm 3q in primary squamous carcinoma of the vagina. Cancer Genet Cytogenet. 2004;148:7-13 pubmed
    ..Age at diagnosis (P=0.031), tumor size (P=0.025), and increased laminin-5 expression (P=0.006) have a significant influence on the survival time...
  44. Van Dam P, Sonnemans H, van Dam P, Verkinderen L, Dirix L. Sentinel node detection in patients with vaginal carcinoma. Gynecol Oncol. 2004;92:89-92 pubmed
    ..The objective was to describe sentinel ode detection in patients with primary and recurrent vaginal carcinoma...
  45. Tran P, Su Z, Lee P, Lavori P, Husain A, Teng N, et al. Prognostic factors for outcomes and complications for primary squamous cell carcinoma of the vagina treated with radiation. Gynecol Oncol. 2007;105:641-9 pubmed
    ..To analyze the results of treatment and identify prognostic factors for primary squamous cell carcinoma (SCCA) of the vagina managed with radiotherapy at a single institution...
  46. Hampl M, Wentzensen N, Vinokurova S, von Knebel Doeberitz M, Poremba C, Bender H, et al. Comprehensive analysis of 130 multicentric intraepithelial female lower genital tract lesions by HPV typing and p16 expression profile. J Cancer Res Clin Oncol. 2007;133:235-45 pubmed
    ..In the current study, HPV infections and oncogene expression were assessed in a large series of patients with multicentric lower genital tract disease to analyze the transformation steps in extracervical disease...
  47. Lee Y, Lee T, Koo T, Cho Y, Park I. Laparoscopic-assisted radical parametrectomy including pelvic and/or paraaortic lymphadenectomy in women after prior hysterectomy-three cases. Gynecol Oncol. 2003;91:619-22 pubmed
    ..This type of surgery for invasive cervical cancer after a hysterectomy or vaginal stump metastasis traditionally requires a major laparotomy; however, a minimal-access approach is now being applied to this type of procedure...
  48. Kushner D, Fleming P, Kennedy A, Wilkinson D, Lee E, Saffle P. High dose rate (192)Ir afterloading brachytherapy for cancer of the vagina. Br J Radiol. 2003;76:719-25 pubmed
    ..Long-term follow-up is needed to further assess late complications, and larger studies are needed to confirm our results...
  49. Herbst A, Ulfelder H, Poskanzer D. Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women. N Engl J Med. 1971;284:878-81 pubmed
  50. Samant R, Lau B, E C, Le T, Tam T. Primary vaginal cancer treated with concurrent chemoradiation using Cis-platinum. Int J Radiat Oncol Biol Phys. 2007;69:746-50 pubmed
    ..To evaluate the feasibility of concurrent weekly Cis-platinum chemoradiation (CRT) in the curative treatment of primary vaginal cancer...
  51. Srodon M, Stoler M, Baber G, Kurman R. The distribution of low and high-risk HPV types in vulvar and vaginal intraepithelial neoplasia (VIN and VaIN). Am J Surg Pathol. 2006;30:1513-8 pubmed
    ..Finally, comparison of the distribution of HPV in the vagina and vulva suggests that VaIN is more closely related to cervical intraepithelial neoplasia than to VIN...
  52. Dalrymple J, Russell A, Lee S, Scudder S, Leiserowitz G, Kinney W, et al. Chemoradiation for primary invasive squamous carcinoma of the vagina. Int J Gynecol Cancer. 2004;14:110-7 pubmed
    ..To report outcomes for patients with primary, invasive, squamous carcinoma of the vagina treated with chemoradiation...
  53. Birnbaum L, Fenton S. Cancer and developmental exposure to endocrine disruptors. Environ Health Perspect. 2003;111:389-94 pubmed
    ..Implications of these new findings suggest that causes of endocrine-related cancers or susceptibility to cancer may be a result of developmental exposures rather than exposures existing at or near the time of tumor detection...
  54. Beller U, Benedet J, Creasman W, Ngan H, Quinn M, Maisonneuve P, et al. Carcinoma of the vagina. FIGO 26th Annual Report on the Results of Treatment in Gynecological Cancer. Int J Gynaecol Obstet. 2006;95 Suppl 1:S29-42 pubmed