vascular neoplasms

Summary

Summary: Neoplasms located in the vasculature system, such as ARTERIES and VEINS. They are differentiated from neoplasms of vascular tissue (NEOPLASMS, VASCULAR TISSUE), such as ANGIOFIBROMA or HEMANGIOMA.

Top Publications

  1. Mehta V, Ananthanarayanan V, Antic T, Krausz T, Milner J, Venkataraman G, et al. Primary benign vascular tumors and tumorlike lesions of the kidney: a clinicopathologic analysis of 15 cases. Virchows Arch. 2012;461:669-76 pubmed publisher
    ..However, lesions mimicking renal malignancy are subjected to surgery. They may exist as isolated lesions or coexist with malignant lesions either in the ipsilateral or the contralateral kidney...
  2. Fiore M, Colombo C, Locati P, Berselli M, Radaelli S, Morosi C, et al. Surgical technique, morbidity, and outcome of primary retroperitoneal sarcoma involving inferior vena cava. Ann Surg Oncol. 2012;19:511-8 pubmed publisher
    ..The aim of the study was to review a monoinstitutional series of IVC resections for RSTS (mainly IVC leiomyosarcoma), focusing on the type of vascular replacement, morbidity, and oncologic outcome...
  3. Shah D, Joyce L, Grogan M, Aubry M, Miller J, Ding W, et al. Recurrent pulmonary intimal sarcoma involving the right ventricular outflow tract. Ann Thorac Surg. 2011;91:e41-2 pubmed publisher
    ..The sarcoma recurred in about 8 weeks. It responded favorably to chemoradiation therapy and shows some signs of regression...
  4. Munene G, Mack L, Moore R, Temple W. Neoadjuvant radiotherapy and reconstruction using autologous vein graft for the treatment of inferior vena cava leiomyosarcoma. J Surg Oncol. 2011;103:175-8 pubmed publisher
    ..This study was undertaken to analyze the outcomes associated with the use of neoadjuvant radiotherapy and IVC reconstruction in the treatment of IVC leiomyosarcoma...
  5. Mann G, Mann L, Levine E, Shen P. Primary leiomyosarcoma of the inferior vena cava: a 2-institution analysis of outcomes. Surgery. 2012;151:261-7 pubmed publisher
    ..Approximately 300 cases of leiomyosarcoma of the inferior vena cava (IVC) have been reported in the literature to date. In this study, we combined the experience from 2 institutions to provide additional clinical outcomes data...
  6. Ganeshalingam S, Rajeswaran G, Jones R, Thway K, Moskovic E. Leiomyosarcomas of the inferior vena cava: diagnostic features on cross-sectional imaging. Clin Radiol. 2011;66:50-6 pubmed publisher
    ..These are rare aggressive tumours that present late with non-specific symptoms and have a poor prognosis...
  7. Yu L, Shi E, Gu T, Xiu Z, Fang Q, Wang C. Intravenous leiomyomatosis with intracardiac extension: a report of two cases. J Card Surg. 2011;26:56-60 pubmed publisher
    ..In this report, we describe two women with leiomyomatosis originating from the uterus and extending into the inferior vena cava to the right ventricle that was successfully resected using a two-stage approach.?..
  8. Ramponi F, Kench J, Simring D, Crawford M, Abadir E, Harris J. Early diagnosis and resection of an asymptomatic leiomyosarcoma of the inferior vena cava prior to caval obstruction. J Vasc Surg. 2012;55:525-8 pubmed publisher
    ..In this case report, we describe an asymptomatic intraluminal leiomyosarcoma of the inferior vena cava diagnosed incidentally prior to caval occlusion during a routine ultrasound examination of the upper abdomen...
  9. Du J, Zhao X, Guo D, Li H, Sun B. Intravenous leiomyomatosis of the uterus: a clinicopathologic study of 18 cases, with emphasis on early diagnosis and appropriate treatment strategies. Hum Pathol. 2011;42:1240-6 pubmed publisher
    ..It is important to adequately sample all uterine leiomyomas and carefully examine the soft tissue on either side of the lower uterine segment below the peritoneal reflection to identify early-stage intravenous leiomyomatosis...

More Information

Publications62

  1. Ote E, Oriuchi N, Miyashita G, Paudyal B, Ishikita T, Arisaka Y, et al. Pulmonary artery intimal sarcoma: the role of ¹?F-fluorodeoxyglucose positron emission tomography in monitoring response to treatment. Jpn J Radiol. 2011;29:279-82 pubmed publisher
    ..Fine-needle biopsy revealed a pathological diagnosis of pulmonary artery intimal sarcoma. The patient was successfully treated with radiotherapy and adjuvant chemotherapy. FDG-PET was used for monitoring the response to therapy...
  2. Angiletta D, Fullone M, Greco L, Marinazzo D, Frontino P, Regina G. Leiomyosarcoma of the inferior vena cava: resection and vascular reconstruction using a dacron graft and an Adam DeWeese clip-three-year follow-up. Ann Vasc Surg. 2011;25:557.e5-9 pubmed publisher
    ..The latter procedure has never been reported before in association with a graft applied for this disease. Technical and clinical details are described...
  3. Matsue K, Hayama B, Iwama K, Koyama T, Fujiwara H, Yamakura M, et al. High frequency of neurolymphomatosis as a relapse disease of intravascular large B-cell lymphoma. Cancer. 2011;117:4512-21 pubmed publisher
    ..A high incidence of neurologic symptoms associated with the central nervous system has been reported, but peripheral nerve involvement (neurolymphomatosis [NL]) rarely has been described...
  4. Al Saif O, Sengupta B, Amr S, Meshikhes A. Leiomyosarcoma of the infra-renal inferior vena cava. Am J Surg. 2011;201:e18-20 pubmed publisher
    ..Complete surgical resection offers the only potential of long-term survival, but survival of unresected patients is generally measured in months. Palliative resections may temporarily improve symptoms but do not offer long-term survival...
  5. Kieffer E, Alaoui M, Piette J, Cacoub P, Chiche L. Leiomyosarcoma of the inferior vena cava: experience in 22 cases. Ann Surg. 2006;244:289-95 pubmed
    ..Although surgical resection combined with chemotherapy is usually not curative, it can achieve reasonably long-term survival. We recommend aggressive operative management using the latest vascular surgery and oncology techniques...
  6. Laskin W, Fanburg Smith J, Burke A, Kraszewska E, Fetsch J, Miettinen M. Leiomyosarcoma of the inferior vena cava: clinicopathologic study of 40 cases. Am J Surg Pathol. 2010;34:873-81 pubmed publisher
  7. Kleymenova E, Everitt J, Pluta L, Portis M, Gnarra J, Walker C. Susceptibility to vascular neoplasms but no increased susceptibility to renal carcinogenesis in Vhl knockout mice. Carcinogenesis. 2004;25:309-15 pubmed
  8. Alexander A, Rehders A, Raffel A, Poremba C, Knoefel W, Eisenberger C. Leiomyosarcoma of the inferior vena cava: radical surgery and vascular reconstruction. World J Surg Oncol. 2009;7:56 pubmed publisher
    ..Due to the topographic relation to the renal veins level-II involvement of the IVC raises special surgical challenges with respect to the maintenance of venous outflow...
  9. Aldrighetti L, Pulitano C, Catena M, Arru M, Guzzetti E, Halliday J, et al. Liver resection with portal vein thrombectomy for hepatocellular carcinoma with vascular invasion. Ann Surg Oncol. 2009;16:1254 pubmed publisher
    ..In surgically resected series, in patients with gross PVTT (PVTT in the portal trunk, its first-order branch, or its second-order branch), the 3-year and 5-year survival rates are reportedly 15% to 28% and 0% to 17%, respectively...
  10. Gaumann A, Bode Lesniewska B, Zimmermann D, Fanburg Smith J, Kirkpatrick C, Hofstadter F, et al. Exploration of the APC/beta-catenin (WNT) pathway and a histologic classification system for pulmonary artery intimal sarcoma. A study of 18 cases. Virchows Arch. 2008;453:473-84 pubmed publisher
    ..Despite myofibroblastic phenotype, APC/beta-catenin pathway changes are rare. Cyclin D1, only expressed in the myxofibrosarcoma-type, is likely transcribed via factors other than beta-catenin...
  11. Ito H, Hornick J, Bertagnolli M, George S, Morgan J, Baldini E, et al. Leiomyosarcoma of the inferior vena cava: survival after aggressive management. Ann Surg Oncol. 2007;14:3534-41 pubmed
    ..Leiomyosarcoma (LMS) of the inferior vena cava (IVC) is exceedingly rare. The role of adjuvant therapy remains undefined. This study evaluated outcomes after aggressive management...
  12. Miracco C, Laurini L, Santopietro R, de Santi M, Sassi C, Neri E, et al. Intimal-type primary sarcoma of the aorta. Report of a case with evidence of rhabdomyosarcomatous differentiation. Virchows Arch. 1999;435:62-6 pubmed
    ..Electron microscopy and the use of a more comprehensive panel of immunohistochemical markers should be applied in the histological classification of"intimal" sarcoma...
  13. Zwicker G, Eyster R, Sells D, Gass J. Spontaneous vascular neoplasms in aged Sprague-Dawley rats. Toxicol Pathol. 1995;23:518-26 pubmed
    Primary benign and malignant vascular neoplasms occurred spontaneously in 8 of 710 male (1.1%) and 4 of 710 female (0...
  14. Hollenbeck S, Grobmyer S, Kent K, Brennan M. Surgical treatment and outcomes of patients with primary inferior vena cava leiomyosarcoma. J Am Coll Surg. 2003;197:575-9 pubmed
    ..The inferior vena cava (IVC) is a rare site for primary soft tissue sarcoma. There are limited data in the literature regarding surgical management of the IVC and longterm survival of these patients...
  15. Cho S, Marsh J, Geller D, Holtzman M, Zeh H, Bartlett D, et al. Surgical management of leiomyosarcoma of the inferior vena cava. J Gastrointest Surg. 2008;12:2141-8 pubmed publisher
    ..Due to its rarity, however, optimal strategies for the management of the primary tumor and subsequent recurrences are not well defined...
  16. Chappell T, Creech C, Parra D, Strauss A, Scholl F, Whitney G. Presentation of pulmonary artery intimal sarcoma in an infant with a history of neonatal valvular pulmonic stenosis. Ann Thorac Surg. 2008;85:1092-4 pubmed publisher
    ..It is usually diagnosed postmortem in patients thought to have pulmonary emboli. We present a case of intimal sarcoma of the pulmonary artery in an infant with a history of neonatal pulmonic stenosis...
  17. Thalheimer A, Fein M, Geissinger E, Franke S. Intimal angiosarcoma of the aorta: report of a case and review of the literature. J Vasc Surg. 2004;40:548-53 pubmed
  18. Shirani S, Soleymanzadeh Ardabili M, Arami M. Intimal sarcoma of the descending aorta. Arch Iran Med. 2007;10:253-4 pubmed
    ..Magnetic resonance imaging also showed an irregular tumor (invasion to the left main bronchus). This case emphasizes the need for a wide panel of immunohistochemical studies in tumor emboli of unknown origin...
  19. Okuno T, Matsuda K, Ueyama K, Oota N, Terada Y, Hohjoh Y, et al. Leiomyosarcoma of the pulmonary vein. Pathol Int. 2000;50:839-46 pubmed
    ..The present case was the oldest in age and to our knowledge was the first reported case with metastasis in a distant lymph node...
  20. Huo L, Lai S, Gladish G, Czerniak B, Moran C. Pulmonary artery angiosarcoma: a clinicopathologic and radiological correlation. Ann Diagn Pathol. 2005;9:209-14 pubmed
    ..The tumor cells were positive for CD31 and vimentin and negative for pan-cytokeratin, CD34, and S100. Two months after surgery, the patient was alive and well...
  21. Bode Lesniewska B, Zhao J, Speel E, Biraima A, Turina M, Komminoth P, et al. Gains of 12q13-14 and overexpression of mdm2 are frequent findings in intimal sarcomas of the pulmonary artery. Virchows Arch. 2001;438:57-65 pubmed
    ..A majority of tumors show a consistent genetic alteration (gains and amplifications in the 12q13-14 region) and overexpression of mdm2, implicating the mdm2/p53 pathway as a possible mechanism in the tumor pathogenesis...
  22. Dadras S, North P, Bertoncini J, Mihm M, Detmar M. Infantile hemangiomas are arrested in an early developmental vascular differentiation state. Mod Pathol. 2004;17:1068-79 pubmed
    ..The immature, incompletely differentiated immunophenotype of proliferating infantile hemangiomas may contribute to their rapid growth during the first few months of life...
  23. Yi E. Tumors of the pulmonary vasculature. Cardiol Clin. 2004;22:431-40, vi-vii pubmed
    ..Secondary involvement of pulmonary vasculature by malignant tumors may rarely mimic a primary vascular tumor or clinically present as unexplained pulmonary hypertension associated with thrombotic microangiopathy...
  24. Thurer R, Thorsen A, Parker J, Karp D. FDG imaging of a pulmonary artery sarcoma. Ann Thorac Surg. 2000;70:1414-5 pubmed
    ..Based on preoperative imaging and intraoperative findings, a right pneumonectomy was performed for what proved to be a pulmonary artery sarcoma...
  25. Strobel K, Bode B, Lardinois D, Exner U. PET-positive fibrous dysplasia--a potentially misleading incidental finding in a patient with intimal sarcoma of the pulmonary artery. Skeletal Radiol. 2007;36 Suppl 1:S24-8 pubmed
    ..In the presented case, an incidentally detected PET-positive asymptomatic fibrous dysplasia was initially misinterpreted as a metastasis in a patient with intimal sarcoma of the pulmonary artery...
  26. Akiyama K, Nakata K, Negishi N, Henmi A. Intimal sarcoma of the thoracic aorta; clinical-course and autopsy finding. Ann Thorac Cardiovasc Surg. 2005;11:135-8 pubmed
    ..The pathological finding was of a primary intimal sarcoma. The patient lived for more than two years excluding the hospitalized period after the diagnosis...
  27. Brown J, Folpe A, Rao P, Lazar A, Paner G, Gupta R, et al. Primary vascular tumors and tumor-like lesions of the kidney: a clinicopathologic analysis of 25 cases. Am J Surg Pathol. 2010;34:942-9 pubmed publisher
  28. Yaguchi C, Oi H, Kobayashi H, Miura K, Kanayama N. A case of intravenous leiomyomatosis with high levels of hyaluronan. J Obstet Gynaecol Res. 2010;36:454-8 pubmed publisher
    ..IVL has viscoelastic properties and contains a large amount of hyaluronan, which may promote invasion during pathogenesis...
  29. Kyriazi M, Stafyla V, Chatzinikolaou I, Koureas A, Chatziioannou A, Kondi Paphiti A, et al. Surgical challenges in the treatment of leiomyosarcoma of the inferior vena cava: analysis of two cases and brief review of the literature. Ann Vasc Surg. 2010;24:826.e13-7 pubmed publisher
    ..Optimal treatment should include complete resection of the malignant lesion with preservation of venous return. We present our experience from two patients treated in our hospital in the last 3 years...
  30. Thapar V, Satoskar R, Kanjan G, Chaudhary A. Leiomyosarcoma of the inferior vena cava: a case report and review of literature. Int Surg. 2005;90:262-5 pubmed
    ..We discuss the clinical presentation imaging findings and review the literature...
  31. Uchida A, Tabata M, Kiura K, Tanimoto Y, Kanehiro A, Aoe M, et al. Successful treatment of pulmonary artery sarcoma by a two-drug combination chemotherapy consisting of ifosfamide and epirubicin. Jpn J Clin Oncol. 2005;35:417-9 pubmed
    ..Surgical resection is currently the most hopeful treatment for pulmonary artery sarcoma. However, intensive chemotherapy is worth trying in unresectable patients...
  32. Huo L, Moran C, Fuller G, Gladish G, Suster S. Pulmonary artery sarcoma: a clinicopathologic and immunohistochemical study of 12 cases. Am J Clin Pathol. 2006;125:419-24 pubmed
    ..Pulmonary artery sarcoma is an uncommon entity with a poor prognosis. The role of early diagnosis, histologic classification, surgical treatment, and adjuvant therapy in patient outcome is discussed...
  33. Subramaniam M, Martinez Rodriguez M, Navarro S, Rosaleny J, Bosch A. Primary intravascular myxoid leiomyosarcoma of the femoral vein presenting clinically as deep vein thrombosis: a case report. Virchows Arch. 2007;450:235-7 pubmed
  34. Yoshidome H, Takeuchi D, Ito H, Kimura F, Shimizu H, Ambiru S, et al. Should the inferior vena cava be reconstructed after resection for malignant tumors?. Am J Surg. 2005;189:419-24 pubmed
    ..Caval replacement after circumferential resection of the inferior vena cava remains controversial. The aim of the current study is to determine whether or not inferior vena cava replacement should be performed...
  35. Gow C, Liaw Y, Chang Y, Chang Y, Yang R. Primary vascular leiomyosarcoma of the femoral vein leading to metastases of scalp and lungs. Clin Oncol (R Coll Radiol). 2005;17:201 pubmed
  36. Illuminati G, Calio F, D Urso A, Giacobbi D, Papaspyropoulos V, Ceccanei G. Prosthetic replacement of the infrahepatic inferior vena cava for leiomyosarcoma. Arch Surg. 2006;141:919-24; discussion 924 pubmed
    ..Resection of the infrahepatic inferior vena cava associated with prosthetic graft replacement for caval leiomyosarcoma is an acceptable procedure to obtain prolonged and good-quality survival...
  37. Tameo M, Calligaro K, Antin L, Dougherty M. Primary leiomyosarcoma of the inferior vena cava: reports of infrarenal and suprahepatic caval involvement. J Vasc Surg. 2010;51:221-4 pubmed publisher
    ..A review of this rare tumor is presented...
  38. Gurbuz A, Yetkin U, Yilik L, Ozdemir T, Turk F. A case of leiomyosarcoma originating from pulmonary vein, occluding mitral inflow. Heart Lung. 2003;32:210-4 pubmed
    ..The tumor was totally removed. Open heart surgery is the acceptable approach for the management of intracardiac tumors, which may cause obstruction of blood flow through the heart...
  39. Dalainas I. Vascular smooth muscle tumors: review of the literature. Int J Surg. 2008;6:157-63 pubmed
    ..This study reviews literature for epidemiology, clinical presentation, diagnosis and management of patients with vascular smooth muscle tumors...
  40. Bieliūniene E, Kavaliauskiene G, Mitraite D, Jonaitiene E, Basevicius A, Lukosevicius S, et al. Leiomyosarcoma of the inferior vena cava. Medicina (Kaunas). 2010;46:200-3 pubmed
    ..Radiological examination revealed retroperitoneal tumor and helped to choose surgical treatment. Histopathological examination confirmed the diagnosis of leiomyosarcoma of the inferior vena cava...
  41. Dew J, Hansen K, Hammon J, McCoy T, Levine E, Shen P. Leiomyosarcoma of the inferior vena cava: surgical management and clinical results. Am Surg. 2005;71:497-501 pubmed
    ..The management of the IVC can be managed with primary repair, ligation, or prosthetic graft. Long-term survival is possible if complete resection can be achieved...
  42. Yan M, Callahan C, Beyer J, Allamneni K, Zhang G, Ridgway J, et al. Chronic DLL4 blockade induces vascular neoplasms. Nature. 2010;463:E6-7 pubmed publisher
    ..Here we show that chronic DLL4 blockade causes pathological activation of endothelial cells, disrupts normal organ homeostasis and induces vascular tumours, raising important safety concerns...
  43. Hines N, Lantos G, Hochzstein J, Gitig A, Deanda A. Osteosarcoma of the lumbosacral spine invading the central venous pathways, right-sided cardiac chambers, and pulmonary artery. Skeletal Radiol. 2007;36:1091-6 pubmed
    ..There is only one other reported case of direct extension into the venous system by an iliac bone osteosarcoma in an adolescent; however, the tumor did not extend into the pulmonary circulation...
  44. Ozbek C, Emrecan B, Calli A, Gurbuz A. Intimal sarcoma of the pulmonary artery with retrograde extension into the pulmonic valve and right ventricle. Tex Heart Inst J. 2007;34:119-21 pubmed
    ..He underwent surgery for obstruction of the right ventricular outflow tract. This is a very rare case of an intimal sarcoma of the pulmonary artery, which we confirmed by pathologic studies...
  45. Manso L, Alvarez E, Quintela M, Cortes Funes H, Hitt R. Primary pulmonary artery sarcoma: report of three cases and review of the literature. Clin Lung Cancer. 2007;8:277-81 pubmed
    ..The mean survival time ranges from 14 months to 18 months. We report 3 cases of PAS treated with surgery and chemotherapy (anthracyclines and ifosfamide) with different outcomes...
  46. Liu C, Zheng Y, Yang X, Shao J, Song X, Liu B, et al. Surgical resection of the inferior vena cava for leiomyosarcoma. Ann Vasc Surg. 2010;24:822.e11-5 pubmed publisher
    ..Our choice of en bloc resection including segment I and II IVC without extracorporeal circulation or prosthetic replacement of the vessels was justified as the patient had normal liver and kidney function after the operation...
  47. Laroia S, Potti A, Rabbani M, Mehdi S, Koch M. Unusual pulmonary lesions: case 3. Pulmonary vein leiomyosarcoma presenting as a left atrial mass. J Clin Oncol. 2002;20:2749-51 pubmed
  48. Pompilio G, Tartara P, Varesi C, Biglioli P. Intimal-type primary sarcoma of the thoracic aorta: an unusual case presenting with left arm embolization. Eur J Cardiothorac Surg. 2002;21:574-6 pubmed
    ..A case of intimal-type primary sarcoma of the thoracic aorta with unusual left arm embolization is reported...
  49. Gaumann A, Petrow P, Mentzel T, Mayer E, Dahm M, Otto M, et al. Osteopontin expression in primary sarcomas of the pulmonary artery. Virchows Arch. 2001;439:668-74 pubmed
  50. Ceyhan M, Danaci M, Elmali M, Ozmen Z. Leiomyosarcoma of the inferior vena cava. Diagn Interv Radiol. 2007;13:140-3 pubmed
    ..We present a case of leiomyosarcoma of the inferior vena cava that extended into the right renal vein and the right iliac vein, as it is a rare case and emphasize the significance of the imaging methods in its diagnosis...
  51. He M, Das K, Blacksin M, Benevenia J, Hameed M. A translocation involving the placental growth factor gene is identified in an epithelioid hemangioendothelioma. Cancer Genet Cytogenet. 2006;168:150-4 pubmed
    ..The strong positivity for both PlGF and VEGF observed in our case implies that the t(10;14)(p13;q24) most likely involves PlGF, which may be one of the genes driving oncogenesis in these tumors...
  52. Fang B, Ng Y, Yeh C. Intravenous leiomyomatosis with extension to the heart: echocardiographic features: a case report. Angiology. 2007;58:376-9 pubmed
    ..She recovered well. Repeat magnetic resonance imaging 6 months following the second operation showed that the inferior vena cava and right atrium were clear of tumor...
  53. Hardwigsen J, Balandraud P, Ananian P, Saïsse J, Le Treut Y. Leiomyosarcoma of the retrohepatic portion of the inferior vena cava: clinical presentation and surgical management in five patients. J Am Coll Surg. 2005;200:57-63 pubmed
    ..For LMS involving the retrohepatic portion of IVC there are limited published data about tumor features, surgical strategies, and IVC replacement...