sebaceous gland neoplasms

Summary

Summary: New abnormal growth of tissue in the SEBACEOUS GLANDS.

Top Publications

  1. Dasgupta T, Wilson L, Yu J. A retrospective review of 1349 cases of sebaceous carcinoma. Cancer. 2009;115:158-65 pubmed publisher
    ..The objective of the current study was to analyze demographic characteristics and outcomes for patients with this malignancy from a large United States-based population registry...
  2. Honavar S, Shields C, Maus M, Shields J, Demirci H, Eagle R. Primary intraepithelial sebaceous gland carcinoma of the palpebral conjunctiva. Arch Ophthalmol. 2001;119:764-7 pubmed
    ..Patients with unexplained chronic unilateral blepharoconjunctivitis or papillary hypertrophy of the palpebral conjunctiva should be considered for biopsy to rule out neoplasia, even when there is no sign of an underlying eyelid mass...
  3. Chao A, Shields C, Krema H, Shields J. Outcome of patients with periocular sebaceous gland carcinoma with and without conjunctival intraepithelial invasion. Ophthalmology. 2001;108:1877-83 pubmed
    ..To evaluate the clinical findings, histopathologic features, methods of management, and outcomes in 25 patients with eyelid sebaceous gland carcinoma with and without conjunctival intraepithelial (pagetoid) invasion...
  4. Abbas O, Mahalingam M. Cutaneous sebaceous neoplasms as markers of Muir-Torre syndrome: a diagnostic algorithm. J Cutan Pathol. 2009;36:613-9 pubmed publisher
    b>Sebaceous gland neoplasms such as adenoma, epithelioma, and carcinoma are uncommon cutaneous tumors. Although sporadic, their occurrence is clinically significant because of their association with Muir-Torre syndrome (MTS)...
  5. Shields J, Demirci H, Marr B, Eagle R, Shields C. Sebaceous carcinoma of the ocular region: a review. Surv Ophthalmol. 2005;50:103-22 pubmed
  6. Becker K, Goldberg M, Helmbold P, Holbach L, Loeffler K, Ballhausen W. Deletions of BRCA1/2 and p53 R248W gain-of-function mutation suggest impaired homologous recombination repair in fragile histidine triad-negative sebaceous gland carcinomas. Br J Dermatol. 2008;159:1282-9 pubmed publisher
    ..However, a significant fraction of periocular sebaceous gland carcinomas exhibits microsatellite stability associated with a frequent loss of the candidate tumour suppressor fragile histidine triad (FHIT)...
  7. Yoon J, Kim S, Lee C, Lew H, Lee S. Clinicopathological analysis of periocular sebaceous gland carcinoma. Ophthalmologica. 2007;221:331-9 pubmed
    ..We analyzed the clinicopathological features and prognosis in patients with periocular sebaceous gland carcinoma...
  8. Poothullil A, Colby K. Topical medical therapies for ocular surface tumors. Semin Ophthalmol. 2006;21:161-9 pubmed
    ..Topical agents were used as both primary and adjuvant therapy. Rates of tumor regression for CIN and squamous cell carcinoma ranged from 80 to 96%, and 70% of pigmented tumors regressed after an average follow-up of 27 months...
  9. Eisen D, Michael D. Sebaceous lesions and their associated syndromes: part I. J Am Acad Dermatol. 2009;61:549-60; quiz 561-2 pubmed publisher
    ..Controversies regarding these lesions will be explored, and any relationship with Muir-Torre syndrome will be discussed...

More Information

Publications62

  1. Ponti G, Ponz de Leon M. Muir-Torre syndrome. Lancet Oncol. 2005;6:980-7 pubmed
  2. Cook B, Bartley G. Treatment options and future prospects for the management of eyelid malignancies: an evidence-based update. Ophthalmology. 2001;108:2088-98; quiz 2099-100, 2121 pubmed
    ..To provide evidence-based clinical recommendations for treatment options and future prospects for the management of common malignant eyelid tumors, including global ratings for the strength of published evidence supporting them...
  3. Rishi K, Font R. Sebaceous gland tumors of the eyelids and conjunctiva in the Muir-Torre syndrome: a clinicopathologic study of five cases and literature review. Ophthalmic Plast Reconstr Surg. 2004;20:31-6 pubmed
    ..To study the sebaceous tumors of eyelid/conjunctiva associated with Muir-Torre syndrome (MTS) and to determine the role of immunohistochemical markers (MSH2, mismatch repair gene) in the diagnosis of patients with MTS...
  4. Font R, Rishi K. Sebaceous gland adenoma of the tarsal conjunctiva in a patient with Muir-Torre syndrome. Ophthalmology. 2003;110:1833-6 pubmed
  5. Tumuluri K, Kourt G, Martin P. Mitomycin C in sebaceous gland carcinoma with pagetoid spread. Br J Ophthalmol. 2004;88:718-9 pubmed
  6. Kiyosaki K, Nakada C, Hijiya N, Tsukamoto Y, Matsuura K, Nakatsuka K, et al. Analysis of p53 mutations and the expression of p53 and p21WAF1/CIP1 protein in 15 cases of sebaceous carcinoma of the eyelid. Invest Ophthalmol Vis Sci. 2010;51:7-11 pubmed publisher
  7. Deprez M, Uffer S. Clinicopathological features of eyelid skin tumors. A retrospective study of 5504 cases and review of literature. Am J Dermatopathol. 2009;31:256-62 pubmed publisher
    ..We further discuss our results with reference to previously published series...
  8. Buitrago W, Joseph A. Sebaceous carcinoma: the great masquerader: emgerging concepts in diagnosis and treatment. Dermatol Ther. 2008;21:459-66 pubmed publisher
    ..Greater awareness and understanding of SC and its behavior has led to earlier diagnosis and appropriate treatment...
  9. Dowd M, Kumar R, Sharma R, Murali R. Diagnosis and management of sebaceous carcinoma: an Australian experience. ANZ J Surg. 2008;78:158-63 pubmed publisher
    ..Periorbital SC is approximately three times more common than extraorbital SC. To date, there are few data from an Australian source to document the prevalence or clinical outcome of this tumour...
  10. Shields C, Naseripour M, Shields J, Eagle R. Topical mitomycin-C for pagetoid invasion of the conjunctiva by eyelid sebaceous gland carcinoma. Ophthalmology. 2002;109:2129-33 pubmed
    ..To evaluate the efficacy of topical mitomycin-C for pagetoid invasion of the conjunctiva by sebaceous gland carcinoma...
  11. Kao G. Carcinoma arising in Bowen's disease. Arch Dermatol. 1986;122:1124-6 pubmed
  12. Bouraoui S, Khaddar R, Mokni M, Badri T, Azaiez M, Dhahri A. [Extrapalpebral sebaceous carcinoma]. Ann Dermatol Venereol. 2006;133:165-7 pubmed
    ..His prognosis depends of the precocity of the diagnosis. This neoplasm is aggressive in 29%, lymph node and visceral metastasis aren't rare...
  13. Kacerovska D, Drlík L, Slezakova L, Michal M, Stehlik J, Sedivcová M, et al. Cutaneous Sebaceous Lesions in a Patient With MUTYH-Associated Polyposis Mimicking Muir-Torre Syndrome. Am J Dermatopathol. 2016;38:915-923 pubmed
    ..Despite striking clinicopathological similarities with Muir-Torre syndrome, the molecular biologic testing confirmed the final diagnosis of MUTYH-associated polyposis. ..
  14. Misago N, Toda S. Sebaceous carcinoma within rippled/carcinoid pattern sebaceoma. J Cutan Pathol. 2016;43:64-70 pubmed publisher
    ..This case shows the possibility that abnormal (malignant) sebaceous germinative cells may originate within a sebaceoma, thereby suggesting that some sebaceous carcinomas may develop from preexisting sebaceomas. ..
  15. Traboulsi E, Zin A, Massicotte S, Kosmorsky G, Kotagal P, Ellis F. Posterior scleral choristoma in the organoid nevus syndrome (linear nevus sebaceus of Jadassohn). Ophthalmology. 1999;106:2126-30 pubmed
    ..To highlight the association of posterior osseous and/or cartilaginous ocular choristomas with epibulbar choristomas and the nevus sebaceus of Jadassohn...
  16. Tanahashi J, Kashima K, Daa T, Yada N, Fujiwara S, Yokoyama S. Merkel cell carcinoma co-existent with sebaceous carcinoma of the eyelid. J Cutan Pathol. 2009;36:983-6 pubmed publisher
    ..Metastatic deposits were identified in the regional lymph nodes, which solely consisted of Merkel cell carcinoma without sebaceous carcinoma. This is the first report of such co-existent lesions...
  17. Tok L, Tok O, Argun M, Ciris I, Baspinar S, Günes A. Corneal limbal sebaceous adenoma. Cornea. 2014;33:425-7 pubmed publisher
    ..The aim of this study was to describe a case of a corneal limbal sebaceous adenoma...
  18. Zehou O, Valeyrie Allanore L, Ortonne N, Chazelas K, Hivelin M, Marchac A, et al. [Neglected skin tumors. Three cases]. Ann Dermatol Venereol. 2012;139:194-8 pubmed publisher
    ..Giant skin tumours are defined as greater than 10 cm in size and are frequently a consequence of neglect. We report three cases of giant skin tumours and discuss possible factors associated with delayed diagnosis and treatment...
  19. Dhingra K, Saroha V, Gupta P, Khurana N. Demodex-associated dermatologic conditions--A coincidence or an etiological correlate. Review with a report of a rare case of sebaceous adenoma. Pathol Res Pract. 2009;205:423-6 pubmed publisher
    ..We report this rare case and review the skin lesions associated with Demodex folliculorum...
  20. Coldron J, Reid I. Muir-Torre syndrome. J R Coll Surg Edinb. 2001;46:178-9 pubmed
    ..A case occurring in Scotland is described and implications for management, screening for members of the family are discussed...
  21. Ansai S, Takeichi H, Arase S, Kawana S, Kimura T. Sebaceous carcinoma: an immunohistochemical reappraisal. Am J Dermatopathol. 2011;33:579-87 pubmed publisher
    ..The detection of AR and ADP was useful for differentiating SC from SCC, whereas the determination of EMA, CA15-3, Ber-EP4, and ADP was valuable in differentiating SC from BCC...
  22. Matthews J, Roberts R, O Reilly D, Schick S, Kingsnorth A. Muir-Torre syndrome: a case for surveillance of the ampulla of Vater. Dig Surg. 2002;19:65-6 pubmed
    ..As an ampullary carcinoma is potentially amenable to surgical resection, particularly when detected early, patients with MTS should undergo regular endoscopic surveillance of the ampulla of Vater...
  23. Halsey M, Calder K, Mathew R, Schlauder S, Morgan M. Expression of alpha-methylacyl-CoA racemase (P504S) in sebaceous neoplasms. J Cutan Pathol. 2010;37:446-51 pubmed publisher
    ..Despite the importance of lipid metabolism in sebum production by sebaceous glands of the skin, there are no studies evaluating the expression of AMACR in sebaceous neoplasms...
  24. Motley R, Douglas Jones A, Holt P. Sebaceous carcinoma: an unusual cause of a rapidly enlarging rhinophyma. Br J Dermatol. 1991;124:283-4 pubmed
    ..We believe the development of this tumour was a random occurrence but the possibility of tumour development should be considered in any rhinophyma showing a rapid increase in size...
  25. Misago N, Narisawa Y. Ripple/Carcinoid pattern sebaceoma with apocrine differentiation. Am J Dermatopathol. 2011;33:94-7 pubmed publisher
  26. Ostler D, Prieto V, Reed J, Deavers M, Lazar A, Ivan D. Adipophilin expression in sebaceous tumors and other cutaneous lesions with clear cell histology: an immunohistochemical study of 117 cases. Mod Pathol. 2010;23:567-73 pubmed publisher
    ..The pattern of adipophilin reactivity is important to observe as membranous vesicular staining is suggestive of intracellular lipids whereas granular cytoplasmic reactivity is not...
  27. Scuderi S, Giaccone M, D Errico E, Maorenzic M, Fontanellaa M, Castellano I, et al. Aggressive sebaceous carcinoma of the head. Chir Ital. 2009;61:401-4 pubmed
    ..In this case, aggressive biological behaviour was observed in a carcinoma arising in an extraorbital area, although it has traditionally been considered a less aggressive neoplasm...
  28. Gáspár K, Veres I, Hunyadi J, Juhasz I. Muir-Torre syndrome: a case of two brothers. Int J Dermatol. 2006;45:1124-6 pubmed
  29. Wyndham M. Naevus sebaceous. Community Pract. 2006;79:234 pubmed
  30. Muthusamy K, Halbert G, Roberts F. Immunohistochemical staining for adipophilin, perilipin and TIP47. J Clin Pathol. 2006;59:1166-70 pubmed
    ..Recently, several anti-adipocytic antibodies that recognise proteins associated with lipid vesicles have been described. These antibodies can be applied to paraffin-wax sections...
  31. Singal A, Dhaliwal U, Bhattacharya S, Rohatgi J, Singh N. Complex ocular choristomas in linear nevus sebaceus syndrome: a report of two cases. J Dermatol. 2001;28:259-64 pubmed
    ..Two cases of linear nevus sebaceus syndrome (LNSS) are described in which ipsilateral facial nevus of Jadassohn was associated with complex ocular choristoma. One patient also had scleral osteomas, a rare occurrence in LNSS...
  32. Kariya Y, Moriya T, Suzuki T, Chiba M, Ishida K, Takeyama J, et al. Sex steroid hormone receptors in human skin appendage and its neoplasms. Endocr J. 2005;52:317-25 pubmed
    ..In sebaceous gland neoplasms, the number of ERalpha positive cases was significantly lower in skin appendage neoplasms than non-..
  33. Kruse R, Rutten A, Schweiger N, Jakob E, Mathiak M, Propping P, et al. Frequency of microsatellite instability in unselected sebaceous gland neoplasias and hyperplasias. J Invest Dermatol. 2003;120:858-64 pubmed
    ..Therefore, screening for microsatellite instability in sebaceous gland neoplasias will be of great value in the detection of an inherited DNA mismatch repair defect, which predisposes to various types of internal cancers...
  34. Kasdan M, Stutts J, Kassan M, Clanton J. Sebaceous gland carcinoma of the finger. J Hand Surg Am. 1991;16:870-2 pubmed
    ..Local excision may not be adequate treatment for a sebaceous gland carcinoma of the digit. Ray amputation was the treatment of choice for this patient...
  35. Kruse R, Rutten A, Hosseiny Malayeri H, Bisceglia M, Friedl W, Propping P, et al. "Second hit" in sebaceous tumors from Muir-Torre patients with germline mutations in MSH2: allele loss is not the preferred mode of inactivation. J Invest Dermatol. 2001;116:463-5 pubmed
    ..Thus, we could show in a sample of sebaceous tumors from patients with genetically proven Muir-Torre syndrome that loss of heterozygosity most probably is not the preferred mode of somatic inactivation of the second MSH2 allele...
  36. Lucares D, Bernardes Filho F, Vega H, Kac B, Pereira M, Nery J. Inguinal ulcerated sebaceous carcinoma: an unusual presentation. An Bras Dermatol. 2013;88:48-51 pubmed publisher
    ..The precise approach to genital ulcers, as shown in this case, is a diagnostic challenge that requires a great deal of effort on the part of the clinician. ..
  37. Grandi F, Colodel M, Rocha R, Sequeira J. Sebaceous metaplasia in a canine mammary gland non-infiltrative carcinoma with myoepithelial component. J Vet Diagn Invest. 2011;23:1230-3 pubmed publisher
  38. Claudius K, Ginzkey C, Gattenlohner S, Müller J, Demmer P, Bröcker E. A red cheek as first clinical sign of a sebaceous lymphadenocarcinoma of the parotid gland with lymphangiosis carcinomatosa and lymph node metastases. Am J Dermatopathol. 2011;33:e50-3 pubmed publisher
    ..To our knowledge, this is the sixth reported case of sebaceous lymphadenocarcinoma and the first case presenting with cervical lymph node metastases and dermatological symptoms revealing lymphangiosis carcinomatosa...
  39. Borczuk A, Sha K, Hisler S, Mann J, Hajdu S. Sebaceous carcinoma of the lung: histologic and immunohistochemical characterization of an unusual pulmonary neoplasm: report of a case and review of the literature. Am J Surg Pathol. 2002;26:795-8 pubmed
    ..This unique tumor extends the spectrum of extraocular, extracutaneous neoplasms with sebaceous differentiation from existing single reports in the hypopharyx and larynx to now include bronchus...
  40. Holbach L, von Moller A, Decker C, Jünemann A, Rummelt Hofmann C, Ballhausen W. Loss of fragile histidine triad (FHIT) expression and microsatellite instability in periocular sebaceous gland carcinoma in patients with Muir-Torre syndrome. Am J Ophthalmol. 2002;134:147-8 pubmed
    ..To report fragile histidine triad expression and microsatellite instability in periocular sebaceous gland carcinoma...
  41. Sun G, Hu Q, Huang X, Tang E. Sebaceous lymphadenoma of parotid gland in a child. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107:253-5 pubmed publisher
    ..The treatment is complete surgical excision, and this tumor is rarely recurrent. Reported here is a case of sebaceous lymphadenoma of the left parotid gland in a 16-year-old boy. A left superficial parotidectomy was performed...
  42. Misago N, Kodera H, Narisawa Y. Sebaceous carcinoma, trichoblastoma, and sebaceoma with features of trichoblastoma in nevus sebaceus. Am J Dermatopathol. 2001;23:456-62 pubmed
    ..The presented case also suggested a close relation between trichoblastoma and sebaceoma. The cytokeratin staining pattern could not distinguish between sebaceous and follicular neoplasms in our case...
  43. Coban Y. Hereditary inheritance of nevus sebaceus. Dermatol Surg. 2005;31:1444 pubmed
  44. Kiratli H, Tarlan B, Firat P. Primary sebaceous carcinoma of the lacrimal gland. Orbit. 2012;31:352-4 pubmed publisher
    ..Also noteworthy is the early propensity of this tumor to spread to regional draining lymph nodes and the parotid gland in particular...
  45. Alhumaidi A. Practical immunohistochemistry of epithelial skin tumor. Indian J Dermatol Venereol Leprol. 2012;78:698-708 pubmed publisher
    ..Diagnosis of epithelial tumor depends largely on morphological features but, in rare cases, immunohistochemical stains are needed for definitive diagnosis...
  46. Esche C, Kruse R, Lamberti C, Friedl W, Propping P, Lehmann P, et al. Muir-Torre syndrome: clinical features and molecular genetic analysis. Br J Dermatol. 1997;136:913-7 pubmed
    ..The search for a causal germline mutation revealed a frameshift mutation in the mismatch repair gene hMSH2 leading to a truncated protein. A presymptomatic molecular diagnosis can be offered to the children of the patient...
  47. Yanaba K, Nakagawa H, Takeda Y, Koyama N, Sugano K. Muir-Torre syndrome caused by partial duplication of MSH2 gene by Alu-mediated nonhomologous recombination. Br J Dermatol. 2008;158:150-6 pubmed
    ..Furthermore, the present case indicates that the dermatologist plays an important role in the diagnosis of MTS and evaluation for latent malignancies...
  48. Weiss G, Shemer A, Trau H. Yellowish, verrucous lesions on the scalp. Am Fam Physician. 2005;71:961-2 pubmed
  49. Neis A, Johansen K, Harms R, Watson W, Brost B. Sonographic characteristics of linear nevus sebaceous sequence. Ultrasound Obstet Gynecol. 2006;27:323-4 pubmed
    ..Other associated sonographic findings include macrocephaly and polyhydramnios. When associated with a midline soft tissue mass, these findings are highly suggestive of the presence of congenital linear nevus sebaceous sequence...
  50. Jung Y, Woo I, Kim M, Han C, Rha E. Palliative 5-fluorouracil and cisplatin chemotherapy in recurrent metastatic sebaceous carcinoma: Case report and literature review. Asia Pac J Clin Oncol. 2016;12:e189-93 pubmed publisher
    ..We suggest that 5-fluorouracil-cisplatin can be considered a feasible and effective treatment modality for recurrent sebaceous carcinoma. ..
  51. Misago N, Inoue T, Toda S. Intraepidermal benign sebaceous neoplasm: apocrine poroma (hidroacanthoma simplex type) with extensive sebaceous differentiation with sebaceoma-like features. J Cutan Pathol. 2016;43:171-6 pubmed publisher
    ..Therefore, the presented apocrine poroma was considered to have some features of (intraepidermal and dermal) sebaceoma. ..
  52. Zouboulis C, Boschnakow A. Chronological ageing and photoageing of the human sebaceous gland. Clin Exp Dermatol. 2001;26:600-7 pubmed
    ..Topical and systemic oestrogens offer treatment options for skin xerosis in menopausal females. A combination of isotretinoin and interferon-alpha may prevent tumour development in patients with Muir-Torre syndrome...
  53. Hisaoka M, Takamatsu Y, Hirano Y, Maeda H, Hamada T. Sebaceous carcinoma of the breast: case report and review of the literature. Virchows Arch. 2006;449:484-8 pubmed
    ..5, suggesting neuroendocrine differentiation that is a hitherto undescribed phenomenon in the mammary tumors with sebaceous features. This case would expand the morphologic diversity of carcinoma of the breast...