ameloblastoma

Summary

Summary: An immature epithelial tumor of the JAW originating from the epithelial rests of Malassez or from other epithelial remnants of the ENAMEL from the developmental period. It is a slowly growing tumor, usually benign, but displays a marked propensity for invasive growth.

Top Publications

  1. Houston G. Oral pathology. Ameloblastoma arising in a dentigerous cyst. J Okla Dent Assoc. 2007;98:28-9 pubmed
  2. Kibe T, Fuchigami T, Kishida M, Iijima M, Ishihata K, Hijioka H, et al. A novel ameloblastoma cell line (AM-3) secretes MMP-9 in response to Wnt-3a and induces osteoclastogenesis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;115:780-8 pubmed publisher
    b>Ameloblastoma has a high risk of bone invasion and local recurrence. However, the mechanisms of bone invasion in ameloblastoma remain unclear...
  3. Hata H, Ebihara M, Onitsuka T, Nakagawa M, Kitagawa Y, Ota Y. Large ameloblastoma of the mandible with hypoproteinemia. Int J Oral Maxillofac Surg. 2008;37:866-9 pubmed publisher
    A case of large ameloblastoma of the mandible with severe hypoproteinemia is reported. The patient, a 53-year-old man, had a large swelling (14 x 11 x 10 cm) from the right cheek to the submandible causing severe hypoproteinemia...
  4. Siriwardena B, Kudo Y, Ogawa I, Tilakaratne W, Takata T. Aberrant beta-catenin expression and adenomatous polyposis coli gene mutation in ameloblastoma and odontogenic carcinoma. Oral Oncol. 2009;45:103-8 pubmed publisher
    ..gene with the mutation of APC gene in the process of development of odontogenic tumors including ameloblastoma and odontogenic carcinoma (OC)...
  5. Hande A, Gadbail A, Sonone A, Chaudhary M, Wadhwan V, Nikam A. Comparative analysis of tumour angiogenesis in solid multicystic and unicystic ameloblastoma by using CD 105 (endoglin). Arch Oral Biol. 2011;56:1635-40 pubmed publisher
    The aim of the present study was to evaluate and compare the expression of CD105 (endoglin) in solid multicystic ameloblastoma (SMA) and unicystic ameloblastoma (UA).
  6. Effiom O, Odukoya O. Desmoplastic ameloblastoma: analysis of 17 Nigerian cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;111:e27-31 pubmed publisher
    This study aimed to add to existing knowledge on 90 cases of desmoplastic ameloblastoma (DA) previously reported in the scientific literature and analyze data that could help speculate on its biologic profile...
  7. Kumamoto H, Ohki K. Detection of Notch signaling molecules in ameloblastomas. J Oral Pathol Med. 2008;37:228-34 pubmed publisher
    ..To evaluate the roles of Notch signaling in the oncogenesis and cytodifferentiation of odontogenic tumors, expression of Notch receptors and ligands was analyzed in ameloblastomas as well as in tooth germs...
  8. Ward B, Edlund S, Sciubba J, Helman J. Ameloblastic carcinoma (primary type) isolated to the anterior maxilla: case report with review of the literature. J Oral Maxillofac Surg. 2007;65:1800-3 pubmed
  9. Salehinejad J, Zare Mahmoodabadi R, Saghafi S, Jafarian A, Ghazi N, Rajaei A, et al. Immunohistochemical detection of p53 and PCNA in ameloblastoma and adenomatoid odontogenic tumor. J Oral Sci. 2011;53:213-7 pubmed
    Although ameloblastoma and adenomatoid odontogenic tumor (AOT) belong to the same group according to the World Health Organization, they show different biologic behaviors...

More Information

Publications80

  1. Kotrashetti V, Kale A, Bhalaerao S, Hallikeremath S. Histopathologic changes in soft tissue associated with radiographically normal impacted third molars. Indian J Dent Res. 2010;21:385-90 pubmed publisher
    ..two follicles showed odontogenic keratocyst, one follicle each of calcifying epithelial odontogenic cyst, ameloblastoma-like proliferation, odontogenic myxoma and odontogenic fibroma. This study showed 58...
  2. Jiang L, Shao C, He D, Li W, Wu X, Cai D. [Correlations of extrocellular matrix metalloproteinase inducer and microvessel density to invasiveness of ameloblastoma]. Ai Zheng. 2008;27:1263-6 pubmed
    ..This study was to evaluate the role of matrix metalloproteinase inducer (EMMPRIN) in angiogenesis in ameloblastomas by analyzing EMMPRIN expression and microvessel density (MVD) in ameloblastomas and odontogenic cysts...
  3. Siar C, Nakano K, Han P, Nagatsuka H, Ng K, Kawakami T. Differential expression of Notch receptors and their ligands in desmoplastic ameloblastoma. J Oral Pathol Med. 2010;39:552-8 pubmed publisher
    ..Notch signaling pathway plays an essential role in tooth development. The ameloblastoma, a benign odontogenic epithelial neoplasm, histologically recapitulates the enamel organ at bell stage...
  4. Siar C, Nakano K, Chelvanayagam P, Ng K, Nagatsuka H, Kawakami T. An unsuspected ameloblastoma in the subpontic region of the mandible with consideration of pathogenesis from the radiographic course. Eur J Med Res. 2010;15:135-8 pubmed
    The purpose of this report is to document a case of unsuspected ameloblastoma involving the right man dibular subpontic region in a 38-year-old Cambodian female patient...
  5. Correnti M, Rossi M, Avila M, Perrone M, Rivera H. Human papillomavirus in ameloblastoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110:e20-4 pubmed publisher
    ..None of the positive cases were related to recurrence rate. We may conclude that HPV low and high risk was detected in our sample of intraosseous ameloblastomas. HPV positivity was observed more in the unicystic cases than solid types. ..
  6. Tanahashi J, Daa T, Yada N, Kashima K, Kondoh Y, Yokoyama S. Mutational analysis of Wnt signaling molecules in ameloblastoma with aberrant nuclear expression of beta-catenin. J Oral Pathol Med. 2008;37:565-70 pubmed publisher
    To clarify the genetic background of ameloblastoma, expression of beta-catenin, and mutational status of genes involved in Wnt signaling pathway were investigated...
  7. Al Otaibi O, Khounganian R, Anil S, Rajendran R. Syndecan-1 (CD 138) surface expression marks cell type and differentiation in ameloblastoma, keratocystic odontogenic tumor, and dentigerous cyst. J Oral Pathol Med. 2013;42:186-93 pubmed publisher
    ..The purpose of this study was to analyze SD-1 expression profile immunohistochemically in archival, paraffin-embedded tissue sections of ameloblastomas and in common odontogenic cysts arising from the same locale...
  8. Fregnani E, da Cruz Perez D, de Almeida O, Kowalski L, Soares F, de Abreu Alves F. Clinicopathological study and treatment outcomes of 121 cases of ameloblastomas. Int J Oral Maxillofac Surg. 2010;39:145-9 pubmed publisher
    ..The ameloblastomas were predominantly solid, affecting the posterior mandible. Important factors for outcome were radiographically multilocular lesions, the presence of ruptured basal cortical bone and histologically follicular tumours. ..
  9. Benlyazid A, Lacroix Triki M, Aziza R, Gomez Brouchet A, Guichard M, Sarini J. Ameloblastic carcinoma of the maxilla: case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104:e17-24 pubmed
    ..A case of ameloblastic carcinoma of the maxilla arising in a 90-year-old patient is presented along with a review of 65 other cases of the international literature...
  10. Zhang B, Zhang J, Huang H, Chen W, Tao Q, Zeng D, et al. Inhibition of ameloblastoma invasion in vitro and in vivo by inhibitor of metalloproteinase-2 activity. J Oral Pathol Med. 2009;38:731-6 pubmed publisher
    b>Ameloblastoma is an odontogenic benign tumor characterized by local invasiveness and most of its local recurrences clinically result from local invasion...
  11. Jivan V, Altini M, Meer S, Mahomed F. Adenomatoid odontogenic tumor (AOT) originating in a unicystic ameloblastoma: a case report. Head Neck Pathol. 2007;1:146-9 pubmed publisher
    ..a case of an extra-follicular AOT, which we believe originated from the epithelial lining of a unicystic ameloblastoma, and reviews the literature...
  12. Siqueira A, Carvalho M, Monteiro A, Freitas V, Jaeger R, Pinheiro J. Matrix metalloproteinases, TIMPs and growth factors regulating ameloblastoma behaviour. Histopathology. 2010;57:128-37 pubmed publisher
    b>Ameloblastoma is an odontogenic neoplasm with local invasiveness and recurrence. We have previously suggested that growth factors and matrix metalloproteinases (MMPs) influence ameloblastoma invasiveness...
  13. Qian Y, Huang H. The role of RANKL and MMP-9 in the bone resorption caused by ameloblastoma. J Oral Pathol Med. 2010;39:592-8 pubmed publisher
    b>Ameloblastoma, a common odontogenic tumor located in jaws, generally leads to severe damage to patient's complexion and masticatory function. To expand in jaws, ameloblastoma must have a mechanism of resorbing the surrounding bone...
  14. Luo D, Feng C, Guo J. Pulmonary metastases from an Ameloblastoma: case report and review of the literature. J Craniomaxillofac Surg. 2012;40:e470-4 pubmed publisher
    ..Despite this, reports of metastasis of these tumours are rare. This report presents a patient with mandibular ameloblastoma that recurred 29 years after surgery and metastasized to both lungs...
  15. Ide F, Mishima K, Yamada H, Horie N, Saito I, Shimoyama T, et al. Unsuspected small ameloblastoma in the alveolar bone: a collaborative study of 14 cases with discussion of their cellular sources. J Oral Pathol Med. 2008;37:221-7 pubmed publisher
    Intraosseous ameloblastoma (IA) is the quintessence of epithelial odontogenic tumor and histologically and behaviorally defined as an undoubted neoplastic process...
  16. Gomes C, Duarte A, Diniz M, Gomez R. Review article: Current concepts of ameloblastoma pathogenesis. J Oral Pathol Med. 2010;39:585-91 pubmed publisher
    b>Ameloblastoma is a locally destructive and invasive tumour that can recur despite adequate surgical removal. Molecular studies have offered interesting findings regarding ameloblastoma pathogenesis...
  17. Seifi S, Shafaie S, Ghadiri S. Microvessel density in follicular cysts, keratocystic odontogenic tumours and ameloblastomas. Asian Pac J Cancer Prev. 2011;12:351-6 pubmed
    Multicystic ameloblastoma is a benign epithelial odontogenic tumor that exhibits a more aggressive behavior than follicular cyst and keratocystic odontogenic tumor (KCOT)...
  18. Ramesh R, Manjunath S, Ustad T, Pais S, Shivakumar K. Unicystic ameloblastoma of the mandible--an unusual case report and review of literature. Head Neck Oncol. 2010;2:1 pubmed publisher
    b>Ameloblastoma is a true neoplasm of odontogenic epithelial origin. It is the second most common odontogenic neoplasm, and only odontoma outnumbers it in reported frequency of occurrence...
  19. Iezzi G, Piattelli A, Rubini C, Artese L, Goteri G, Fioroni M, et al. CD10 expression in stromal cells of ameloblastoma variants. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105:206-9 pubmed
    ..study in a series of ameloblastomas with different histology to explore the existence of a correlation between CD10 immunoreactivity in peritumoral stromal cells and the type of ameloblastoma with a high risk of local recurrence.
  20. Mendenhall W, Werning J, Fernandes R, Malyapa R, Mendenhall N. Ameloblastoma. Am J Clin Oncol. 2007;30:645-8 pubmed
    ..article is to review the pertinent literature and discuss the optimal treatment and outcomes for patients with ameloblastoma. Ameloblastoma is an uncommon benign, locally aggressive odontogenic neoplasm that usually occurs in the ..
  21. Singer S, Mupparapu M, Philipone E. Cone beam computed tomography findings in a case of plexiform ameloblastoma. Quintessence Int. 2009;40:627-30 pubmed
    b>Ameloblastoma is a fairly common and highly aggressive odontogenic tumor of epithelial origin. It is primarily seen in adults in the third to fifth decade of life...
  22. Gadbail A, Mankar Gadbail M, Hande A, Chaudhary M, Gondivkar S, Korde S, et al. Tumor angiogenesis: role in locally aggressive biological behavior of ameloblastoma and keratocystic odontogenic tumor. Head Neck. 2013;35:329-34 pubmed publisher
    The purpose of this study was to assess and compare angiogenesis in ameloblastoma, keratocystic odontogenic tumors, dentigerous cysts, and normal oral mucosa.
  23. Luo H, Li T. Odontogenic tumors: a study of 1309 cases in a Chinese population. Oral Oncol. 2009;45:706-11 pubmed publisher
    ..06% were malignant. The most frequent benign tumor was keratocystic odontogenic tumor (38.73%), followed by ameloblastoma (36.52%) and odontomas (6.11%). The prevalence of the remaining tumors appears to be rare...
  24. Dissanayake R, Jayasooriya P, Siriwardena D, Tilakaratne W. Review of metastasizing (malignant) ameloblastoma (METAM): pattern of metastasis and treatment. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;111:734-41 pubmed publisher
    The rare malignant odontogenic tumor, metastasizing (malignant) ameloblastoma (METAM) is reviewed with the aim of analyzing the pattern of disease and treatment of cervical metastasis based, on 2005 World Health Organization ..
  25. Sauk J, Nikitakis N, Scheper M. Are we on the brink of nonsurgical treatment for ameloblastoma?. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110:68-78 pubmed publisher
    ..Here we review the sonic hedgehog (SHH) and PI3K/Akt/mTOR signaling pathways, their role in ameloblastoma, a locally aggressive odontogenic tumor, and evidence for consideration of therapeutic approaches that target ..
  26. Yoon H, Jo B, Shin W, Cho Y, Lee J, Hong S, et al. Comparative immunohistochemical study of ameloblastoma and ameloblastic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112:767-76 pubmed publisher
    Ameloblastic carcinoma combines the histologic features of ameloblastoma with cytologic atypia, regardless of whether it has metastasized...
  27. Koukourakis G, Miliadou A, Sotiropoulou Lontou A. Ameloblastoma, a rare benign odontogenic tumour: an interesting tumour review targeting the role of radiation therapy. Clin Transl Oncol. 2011;13:793-7 pubmed publisher
    b>Ameloblastoma is known as a benign, slow-growing, rare, odontogenic neoplasm...
  28. Lapthanasupkul P, Poomsawat S, Chindasombatjaroen J. Investigation of basement membrane proteins in a case of granular cell ameloblastoma. Int J Oral Sci. 2012;4:45-9 pubmed publisher
    Granular cell ameloblastoma is a rare, benign neoplasm of the odontogenic epithelium. A case of massive granular cell ameloblastoma in a 44-year-old Thai female is reported...
  29. Kishino M, Murakami S, Yuki M, Iida S, Ogawa Y, Kogo M, et al. A immunohistochemical study of the peripheral ameloblastoma. Oral Dis. 2007;13:575-80 pubmed
    Peripheral ameloblastoma (PA) is a rare variant of ameloblastoma occurring in the extraosseous region...
  30. Maya R, Sekar B, Murali S. Comparative evaluation of expression of proliferating cell nuclear antigen in variants of ameloblastoma and ameloblastic carcinoma. Indian J Dent Res. 2012;23:15-9 pubmed publisher
    To evaluate the use of proliferating cell nuclear antigen index in the different histopathological variants of ameloblastoma, such as the follicular, plexiform, and unicystic types, and in ameloblastic carcinoma by immunohistochemical ..
  31. Wang A, Zhang B, Huang H, Zhang L, Zeng D, Tao Q, et al. Suppression of local invasion of ameloblastoma by inhibition of matrix metalloproteinase-2 in vitro. BMC Cancer. 2008;8:182 pubmed publisher
    ..Ameloblastomas are odontogenic neoplasms characterized by local invasiveness. This study was conducted to address the role of matrix metalloproteinase-2 (MMP-2) in the invasiveness of ameloblastomas...
  32. Yavagal C, Anegundi R, Shetty S. Unicystic plexiform ameloblastoma: an insight for pediatric dentists. J Indian Soc Pedod Prev Dent. 2009;27:70-4 pubmed publisher
    ..The term plexiform unicystic ameloblastoma refers to a pattern of epithelial proliferation that has been described in cystic lesions of the jaws...
  33. Kim B, Yoon J, Choi B, Lee J. Mandibular reconstruction with autologous human bone marrow stem cells and autogenous bone graft in a patient with plexiform ameloblastoma. J Craniofac Surg. 2013;24:e409-11 pubmed publisher
    b>Ameloblastoma is a histologically benign tumor, but it shows a tendency of locally aggressive behavior...
  34. Sathi G, Inoue M, Harada H, Rodriguez A, Tamamura R, Tsujigiwa H, et al. Secreted frizzled related protein (sFRP)-2 inhibits bone formation and promotes cell proliferation in ameloblastoma. Oral Oncol. 2009;45:856-60 pubmed publisher
    ..frizzled related protein (sFRP)-2, a Wnt antagonist, was strongly expressed by both stromal and tumor cells of ameloblastoma. The aim of this study is to evaluate whether sFRP-2 secreted from tumor cells have any direct role in ..
  35. Van Dam S, Unni K, Keller E. Metastasizing (malignant) ameloblastoma: review of a unique histopathologic entity and report of Mayo Clinic experience. J Oral Maxillofac Surg. 2010;68:2962-74 pubmed publisher
    To provide a comprehensive review of metastasizing (malignant) ameloblastoma, establish a new baseline of valid cases using histologic criteria and minimum documentation, and report 3 cases from the Mayo Clinic files.
  36. Gratzinger D, Salama M, Poh C, Rouse R. Ameloblastoma, calcifying epithelial odontogenic tumor, and glandular odontogenic cyst show a distinctive immunophenotype with some myoepithelial antigen expression. J Oral Pathol Med. 2008;37:177-84 pubmed publisher
    ..In the 1980s, an ultrastructural study identified a population of myoepithelial-like cells in calcifying epithelial odontogenic tumor. Myoepithelial derived tumors have since been shown to have distinct immunohistochemical profiles...
  37. Masloub S, Abdel Azim A, Elhamid E. CD10 and osteopontin expression in dentigerous cyst and ameloblastoma. Diagn Pathol. 2011;6:44 pubmed publisher
    To investigate the expression of CD10 and osteopontin in dentigerous cyst and ameloblastoma and to correlate their expression with neoplastic potentiality of dentigerous cyst and local invasion and risk of local recurrence in ..
  38. Catherine Z, Isaac S, Cotton F, Roch J, Rousset M, Bouletreau P, et al. [Giant ameloblastoma of the mandible]. Rev Stomatol Chir Maxillofac Chir Orale. 2013;114:97-101 pubmed publisher
    Giant ameloblastomas are more common in developing countries. They raise a serious problem of management. We present the case of one of the largest ameloblastoma ever reported.
  39. Butt F, Guthua S, Awange D, Dimba E, Macigo F. The pattern and occurrence of ameloblastoma in adolescents treated at a university teaching hospital, in Kenya: a 13-year study. J Craniomaxillofac Surg. 2012;40:e39-45 pubmed publisher
    b>Ameloblastoma presenting in the adolescent age group is rare with few studies documenting their occurrence.
  40. Bello I, Alanen K, Slootweg P, Salo T. Alpha-smooth muscle actin within epithelial islands is predictive of ameloblastic carcinoma. Oral Oncol. 2009;45:760-5 pubmed publisher
    b>Ameloblastoma is the most common clinically significant odontogenic tumor. It is considered benign but locally invasive and associated with variable clinico-pathological behavior...
  41. Alaeddini M, Salah S, Dehghan F, Eshghyar N, Etemad Moghadam S. Comparison of angiogenesis in keratocystic odontogenic tumours, dentigerous cysts and ameloblastomas. Oral Dis. 2009;15:422-7 pubmed publisher
    ..The aim of the present study was to evaluate and compare angiogenesis in keratocystic odontogenic tumours, dentigerous cysts (DCs) and ameloblasomas using monoclonal antibody against CD34...
  42. Eckardt A, Kokemüller H, Flemming P, Schultze A. Recurrent ameloblastoma following osseous reconstruction--a review of twenty years. J Craniomaxillofac Surg. 2009;37:36-41 pubmed publisher
    The adequate therapy of ameloblastoma may require a compromise between the least destructive treatment possible of a benign tumour and a sufficiently radical method to prevent recurrences...
  43. Adeline V, Dimba E, Wakoli K, Njiru A, Awange D, Onyango J, et al. Clinicopathologic features of ameloblastoma in Kenya: a 10-year audit. J Craniofac Surg. 2008;19:1589-93 pubmed publisher
    ..2%) were of the solid/multicystic subtype; 8 (5.3%) were unicystic; 1 (0.5%) was of extraosseous origin; 1 (0.5%) was desmoplastic; 9 (6.0%) were malignant, and 12 of the records had no histopathologic pattern specified...
  44. Farias L, Gomes C, Brito J, Galvão C, Diniz M, de Castro W, et al. Loss of heterozygosity of the PTCH gene in ameloblastoma. Hum Pathol. 2012;43:1229-33 pubmed publisher
    b>Ameloblastoma is a locally aggressive benign neoplasm derived from odontogenic epithelium, with high recurrence rates...
  45. Florescu A, Simionescu C, Ciurea R, Pitru A. P53, Bcl-2 and Ki67 immunoexpression in follicular solid ameloblastomas. Rom J Morphol Embryol. 2012;53:105-9 pubmed
    ..2%). Typical follicular ameloblastoma was present in 70.6% of analyzed tumors...
  46. Zhang B, Zhang J, Huang H, Xu Z, Xie H. Expression and role of metalloproteinase-2 and endogenous tissue regulator in ameloblastoma. J Oral Pathol Med. 2010;39:219-22 pubmed publisher
    b>Ameloblastoma is a frequently encountered odontogenic benign tumor characterized by local invasiveness and high risk of recurrence...
  47. Siar C, Nagatsuka H, Han P, Buery R, Tsujigiwa H, Nakano K, et al. Differential expression of canonical and non-canonical Wnt ligands in ameloblastoma. J Oral Pathol Med. 2012;41:332-9 pubmed publisher
    ..Wnt signaling is essential for odontogenesis. The ameloblastoma is an odontogenic epithelial neoplasm of enamel organ origin...
  48. Sun Z, Wu Y, Cheng N, Zwahlen R, Zhao Y. Desmoplastic ameloblastoma - A review. Oral Oncol. 2009;45:752-9 pubmed publisher
    Among the ameloblastomas, the desmoplastic variation is rare. The desmoplastic ameloblastoma (DA) is characterized by specific clinical, imaging, and histological features...
  49. Brkic A, Mutlu S, Koçak Berberoğlu H, Olgac V. Pathological changes and immunoexpression of p63 gene in dental follicles of asymptomatic impacted lower third molars: an immunohistochemical study. J Craniofac Surg. 2010;21:854-7 pubmed publisher
    ..The aim of this study was to examine the pathologic changes and immunoexpressivity of p63 gene in dental follicles (DFs) of asymptomatic partially and completely impacted lower third molars...
  50. Katsura K, Maruyama S, Suzuki M, Saku T, Takagi R, Hayashi T. A case of desmoplastic ameloblastoma arising in the maxillary alveolus: the origin and time-course changes in the early stage of tumour development observed on dental radiographs. Dentomaxillofac Radiol. 2011;40:126-9 pubmed publisher
    In this article we report a case of desmoplastic ameloblastoma in which chronological changes in the early development can be observed on dental radiographs...
  51. Hertog D, Schulten E, Leemans C, Winters H, van der Waal I. Management of recurrent ameloblastoma of the jaws; a 40-year single institution experience. Oral Oncol. 2011;47:145-6 pubmed publisher
    b>Ameloblastoma is a histologically almost always benign odontogenic tumor with a high rate of recurrence if not removed completely. Therefore, radical surgery is the treatment of choice of a primary ameloblastoma...
  52. Rizzardi C, Leocata P, Ventura L, Zweyer M, Brollo A, Schneider M, et al. Apoptosis-related factors (TRAIL, DR4, DR5, DcR1, DcR2, apoptotic cells) and proliferative activity in ameloblastomas. Anticancer Res. 2009;29:1137-42 pubmed
    ..Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a recently identified death factor that acts as a potent apoptosis inducer in ameloblastomas...
  53. Vered M, Peleg O, Taicher S, Buchner A. The immunoprofile of odontogenic keratocyst (keratocystic odontogenic tumor) that includes expression of PTCH, SMO, GLI-1 and bcl-2 is similar to ameloblastoma but different from odontogenic cysts. J Oral Pathol Med. 2009;38:597-604 pubmed publisher
    ..Identification of mutations in the PTCH gene in some of the OKCs that were expected to produce truncated proteins, resulting in loss of control of the cell cycle, provided additional support for OKCs having a neoplastic nature...
  54. Zhang L, Zeng D, Huang H, Wang J, Tao Q, Pan C, et al. Tissue inhibitor of metalloproteinase-2 inhibits ameloblastoma growth in a new mouse xenograft disease model. J Oral Pathol Med. 2010;39:94-102 pubmed publisher
    ..This study was conducted to develop a new animal model of ameloblastoma and to address the role of tissue inhibitor of metalloproteinase-2 (TIMP-2) and matrix metalloproteinase-2 (..
  55. Dhanuthai K, Chantarangsu S, Rojanawatsirivej S, Phattarataratip E, Darling M, Jackson Boeters L, et al. Ameloblastoma: a multicentric study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;113:782-8 pubmed publisher
    The objective of this study was to supplement the current ameloblastoma database by reporting the clinicopathologic features of ameloblastoma from Asia and North America.
  56. Ponti G, Pollio A, Mignogna M, Pellacani G, Pastorino L, Bianchi Scarra G, et al. Unicystic ameloblastoma associated with the novel K729M PTCH1 mutation in a patient with nevoid basal cell carcinoma (Gorlin) syndrome. Cancer Genet. 2012;205:177-81 pubmed publisher
    ..of NBCCS in a 38-year-old man with an early onset of clinical signs and symptoms and an associated unicystic ameloblastoma, histopathologically showing basaloid differentiation and intraluminal growth...
  57. Guzmán Medrano R, Arreola Rosales R, Shibayama M, Silva Olivares D, Bologna Molina R, Rodríguez M. Tumor-associated macrophages and angiogenesis: a statistical correlation that could reflect a critical relationship in ameloblastoma. Pathol Res Pract. 2012;208:672-6 pubmed publisher
    ..b>Ameloblastoma is one of the most frequent odontogenic tumors and an excellent model for the study of neoplasm progression ..
  58. Shashikanth M, Neetha M, Ali I, Shambulingappa P. Desmoplastic ameloblastoma in the maxilla: a case report and review of literature. Indian J Dent Res. 2007;18:214-7 pubmed
    Desmoplastic ameloblastoma (DA) is a rare variant of ameloblastoma (AM). The location of this lesion, its histology and radiological features differ from those of conventional AM...
  59. Rajaonarison Ny Ony N, Randriamarolahy A, Randrianjanahary O, Ahmad A, Bruneton J. Giant ameloblastoma. Clin Imaging. 2012;36:146-8 pubmed publisher
    b>Ameloblastoma is the most frequent of the odontogenic tumors. We report a case of a giant ameloblastoma involving the maxillary region and describe its ultrasonography and computed tomography findings.
  60. Hertog D, Bloemena E, Aartman I, van der Waal I. Histopathology of ameloblastoma of the jaws; some critical observations based on a 40 years single institution experience. Med Oral Patol Oral Cir Bucal. 2012;17:e76-82 pubmed
    ..In conclusion, the current histopathological classification of benign intraosseous ameloblastoma does not seem to have clinical relevance with the possible exception of the luminal unicystic ameloblastoma ..
  61. Borkosky S, Gunduz M, Beder L, Tsujigiwa H, Tamamura R, Gunduz E, et al. Allelic loss of the ING gene family loci is a frequent event in ameloblastoma. Oncol Res. 2010;18:509-18 pubmed
    b>Ameloblastoma is the most frequently encountered odontogenic tumor, characterized by a locally invasive behavior, frequent recurrences, and, although rare, metastatic capacity...
  62. Sathi G, Han P, Tamamura R, Nagatsuka H, Hu H, Katase N, et al. Immunolocalization of cell signaling molecules in the granular cell ameloblastoma. J Oral Pathol Med. 2007;36:609-14 pubmed
    Bone morphogenic protein (BMP) and Wnt signaling pathway molecules play important roles in cytodifferentiation and cell proliferation. We attempted to localize these signaling molecules in the granular cell ameloblastoma.
  63. Darshani Gunawardhana K, Jayasooriya P, Rambukewela I, Tilakaratne W. A clinico-pathological comparison between mandibular and maxillary ameloblastomas in Sri Lanka. J Oral Pathol Med. 2010;39:236-41 pubmed publisher
    ..The aim of this retrospective study was to analyse the relative prevalence and the clinico-pathological characteristics of mandibular and maxillary ameloblastomas in Sri Lanka...
  64. Mesgarzadeh A, Esmailzadeh H, Abdolrahimi M, Shahamfar M. Pathosis associated with radiographically normal follicular tissues in third molar impactions: a clinicopathological study. Indian J Dent Res. 2008;19:208-12 pubmed
    ..The follicular tissue around impacted third molars has a potential to develop pathosis. However, it is generally assumed that the absence of abnormal radiolucency indicates the presence of a normal follicle...
  65. Sannomiya E, Silva J, Brito A, Saez D, Angelieri F, Dalben G. Surgical planning for resection of an ameloblastoma and reconstruction of the mandible using a selective laser sintering 3D biomodel. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106:e36-40 pubmed publisher
    b>Ameloblastoma is a benign locally aggressive infiltrative odontogenic lesion. It is characterized by slow growth and painless swelling...
  66. Oliveira Neto H, Spíndula Filho J, Dallara M, Silva C, Mendonça E, Batista A. Unicystic ameloblastoma in a child: a differential diagnosis from the dentigerous cyst and the inflammatory follicular cyst. J Dent Child (Chic). 2007;74:245-9 pubmed
    Unicystic ameloblastoma (UA) is a benign epithelial odontogenic tumor of the jaws with an aggressive potential that commonly occurs in children...
  67. Stathopoulos P, Mezitis M, Kappatos C, Titsinides S, Stylogianni E. Cysts and tumors associated with impacted third molars: is prophylactic removal justified?. J Oral Maxillofac Surg. 2011;69:405-8 pubmed publisher
    ..The aim of this retrospective analysis was to determine the frequency and type of cysts and tumors related to impacted third molars (ITMs) in Greek patients. Indications, complications, risks, and benefits of ITM removal are also discussed...
  68. Bologna Molina R, Mosqueda Taylor A, Lopez Corella E, Almeida O, Carrasco Daza D, Garcia Vazquez F, et al. Syndecan-1 (CD138) and Ki-67 expression in different subtypes of ameloblastomas. Oral Oncol. 2008;44:805-11 pubmed publisher
    b>Ameloblastoma is the most frequent odontogenic tumor and is considered a benign, but locally invasive, neoplasm with variable clinico-pathological expression...
  69. Sham E, Leong J, Maher R, Schenberg M, Leung M, Mansour A. Mandibular ameloblastoma: clinical experience and literature review. ANZ J Surg. 2009;79:739-44 pubmed publisher
    b>Ameloblastoma is a locally aggressive odontogenic tumour of the mandible and maxilla that, if neglected, can cause severe facial disfigurement and functional impairment...
  70. Muraki E, Nakano K, Maeda H, Takayama M, Jinno M, Kubo K, et al. Immunohistochemical localization of Notch signaling molecules in ameloblastomas. Eur J Med Res. 2011;16:253-7 pubmed
    We examined Notch signaling molecules, Notch1 and Jagged1, in serial large cases of typical solid/multicystic ameloblastoma. In general, Notch positive staining products were frequently detected in the cytoplasms of the cells...
  71. Montoro J, Tavares M, Melo D, Franco R, Mello Filho F, Xavier S, et al. Mandibular ameloblastoma treated by bone resection and immediate reconstruction. Braz J Otorhinolaryngol. 2008;74:155-7 pubmed
    Multicystic ameloblastoma mainly affects adult patients between the third and seventh decades of life, frequently in the posterior region of the mandible...