spindle cell nevus

Summary

Summary: A form of pigmented nevus showing intense melanocytic activity around the dermo-epidermal junction. Large numbers of spindle-shaped melanocytes proliferate downward toward the dermis and usually a large amount of pigment is present. It was first described in 1976 and the bulk of patients reported have been young females with the lesions presenting on the thighs. (From Rook et al., Textbook of Dermatology, 4th ed, 1992, p185)

Top Publications

  1. Morkin M, Kapadia M, Laver N. Pigmented Spindle Cell Nevus of Reed of the Eyelid. Ocul Oncol Pathol. 2017;3:176-180 pubmed publisher
    To report the clinical, pathological, and immunohistochemical features of the first pigmented spindle cell nevus (PSCN) of Reed documented to have appeared in the eyelid.
  2. Val Bernal J, Hermana S. Dermal plexiform spindle cell lipoma. Rom J Morphol Embryol. 2016;57:875-878 pubmed
    ..7 years. Clinical diagnosis suggested a lipomatous or neural tumor in six cases. The main differential diagnosis includes dermal intraneural plexiform neurofibroma and purely intradermal monophasic plexiform spindle cell nevus.
  3. Dal Pozzo V, Benelli C, Restano L, Gianotti R, Cesana B. Clinical review of 247 case records of Spitz nevus (epithelioid cell and/or spindle cell nevus). Dermatology. 1997;194:20-5 pubmed
    ..Spitz nevus has clinically been described as a dome-shaped usually nonpigmented papular or nodular lesion variable in color from pink to red...
  4. Sade S, Al Habeeb A, Ghazarian D. Spindle cell melanocytic lesions: part II--an approach to intradermal proliferations and horizontally oriented lesions. J Clin Pathol. 2010;63:391-409 pubmed publisher
  5. Massi G. Melanocytic nevi simulant of melanoma with medicolegal relevance. Virchows Arch. 2007;451:623-47 pubmed
    ..For each single 'pair' of morphological look-alikes, a specific set of morphological, immunohistochemical and genetic criteria is provided...
  6. Sakai H, Kuroda K, Hara D, Tajima S. Coexistence of spindle cell lipoma and ordinary lipoma. J Dermatol. 2004;31:831-4 pubmed
  7. Suo Z, Nesland J. Electron microscopy in diagnosis of spindle cell tumors. Semin Diagn Pathol. 2003;20:5-12 pubmed
    ..In this article, we discuss the role of electron microscopy in diagnosis of spindle cell tumors and focus upon some more recently described entities...
  8. Ide F, Shimoyama T, Horie N. Post-traumatic spindle cell nodule misdiagnosed as a herniation of the buccal fat pad. Oral Oncol. 2000;36:121-4 pubmed
    ..The morphologic features, proliferating cell type, and benign clinical course are identical to the post-operative spindle cell nodules that occur in the genitourinary tract...
  9. Tamburrini G, Gessi M, Colosimo C, Lauriola L, Giangaspero F, Di Rocco C. Infantile myofibromatosis of the central nervous system. Childs Nerv Syst. 2003;19:650-4 pubmed
    ..Small lesions or tumor residuals in asymptomatic children without visceral involvement should be closely observed as first choice...

More Information

Publications29

  1. Evans M, Sanders D, Grant J, Blessing K. Expression of Melan-A in Spitz, pigmented spindle cell nevi, and congenital nevi: comparative immunohistochemical study. Pediatr Dev Pathol. 2000;3:36-9 pubmed
    ..Melan-A is much cleaner than S100 protein, having no background staining, and in skin appears to be specific for melanocytes. The nonmelanocytic lesions did not express Melan-A...
  2. Camargo M, Boin I, Mainnardi J, de Lourdes M, Ayrizono S, Coy C, et al. Extragastrointestinal stromal tumor and liver transplantation: case report and review. Transplant Proc. 2008;40:3781-3 pubmed publisher
    ..0 x 3.0 cm spindle cell stromal tumor. The immunohistochemical profile was compatible with a GIST, with 5 mitosis per 50 high-powered fields. This tumor is extremely rare after liver transplantation but has shown a good outcome up to now...
  3. Plótár V, Szentirmay Z, Orosz Z. [Reactivity of five different antibodies with benign and malignant melanocytic lesions]. Magy Onkol. 2008;52:363-73 pubmed publisher
    ..We have concluded that the histological diagnosis of melanocytic tumors is based on the detailed examination of traditional HE slides and the immunohistochemical methods only confirm or weaken our opinion...
  4. Gulbinowicz Gowkielewicz M, Kibiłda B, Gugała K. Spindle cell lipoma of the vestibule of the nose. Otolaryngol Head Neck Surg. 2008;139:325-6 pubmed publisher
  5. Hameed M, Clarke K, Amer H, Mahmet K, Aisner S. Cellular angiofibroma is genetically similar to spindle cell lipoma: a case report. Cancer Genet Cytogenet. 2007;177:131-4 pubmed
    ..To our knowledge, this is the first report of cytogenetic changes in cellular angiofibroma. The genetic overlap of these entities supports their origin from the same mesenchymal stem cell...
  6. Hantschke M. [Hypopigmented melanocytic tumors with spindle cells. A review]. Pathologe. 2007;28:403-10 pubmed
    ..The spindle cell melanoma must be distinguished from other types of malignant spindle cell neoplasms, which can involve the skin. The differential diagnosis with such tumors is entrusted mainly to immunostaining...
  7. Boman F, Sfeir R. [Ileal obstructive spindle cell tumor in a child]. Ann Pathol. 2006;26:225-7 pubmed
  8. Orosz Z, Tornoczky T, Sapi Z. Gastrointestinal stromal tumors: a clinicopathologic and immunohistochemical study of 136 cases. Pathol Oncol Res. 2005;11:11-21 pubmed
    ..6% of examined cases. Only one case showed desmin reactivity and seven had S100 positive tumor cells. For h-caldesmon 39 cases proved to be positive (60.9% of the tested cases)...
  9. Chamlin S, Williams M. Pigmented lesions in adolescents. Adolesc Med. 2001;12:v, 195-212 pubmed
    ..e., increased melanin content) that are not associated with malignancy...
  10. Maurichi A, Baldi M, Bartoli C, Bono A, Camerini T, Moglia D, et al. Pigmented spindle-cell nevus: a melanoma simulator. Dermatol Online J. 2004;10:5 pubmed
  11. Val Bernal J, Rubio S, Garijo M, González Vela M. Extragenital subcutaneous cellular angiofibroma. Case report. APMIS. 2007;115:254-8 pubmed
    ..Extragenital CAF, except for location, shows similar clinicopathological features to genital CAF. Simple tumorectomy appears to be adequate treatment. Morphologically, CAF is closely related to spindle cell lipoma...
  12. Firoz B, Kennedy J, Henning J. Dermoscopy and suture marking as a tool to enhance diagnosis of pigmented lesions. Dermatol Surg. 2008;34:1104-7 pubmed publisher
  13. Requena C, Requena L, Sánchez Yus E, Kutzner H, Llombart B, Sanmartin O, et al. Hypopigmented Reed nevus. J Cutan Pathol. 2008;35 Suppl 1:87-9 pubmed publisher
    Reed nevus, also named pigmented spindle cell nevus, is a peculiar melanocytic nevus, now regarded as a variant of Spitz nevus by the majority of authors...
  14. Erol N, Oner U, Artan S, Isiksoy S, Yurdakul S. Chromosomal abnormalities, p53 and Bcl-2 expression and clinical outcome in choroidal melanoma. Melanoma Res. 2004;14:473-8 pubmed
    ..To determine whether alterations of p53, Bcl-2 and chromosomes were present in choroidal melanoma and to further characterize the prognosis of these changes...
  15. Spendlove H, Damato B, Humphreys J, Barker K, Hiscott P, Houlston R. BRAF mutations are detectable in conjunctival but not uveal melanomas. Melanoma Res. 2004;14:449-52 pubmed
    ..We conclude that uveal melanomas arise independently of oncogenic BRAF mutations, but the development of a proportion of conjunctival tumours involves mutation of this gene...
  16. Sade S, Al Habeeb A, Ghazarian D. Spindle cell melanocytic lesions--part I: an approach to compound naevoidal pattern lesions with spindle cell morphology and Spitzoid pattern lesions. J Clin Pathol. 2010;63:296-321 pubmed publisher
  17. Seregard S. Pigmented spindle cell naevus of reed presenting in the conjunctiva. Acta Ophthalmol Scand. 2000;78:104-6 pubmed
    ..This study aimed to present the clinical and histopathological features of a pigmented spindle cell naevus (PSCN) appearing in the conjunctiva...
  18. Dandekar M, McHugh J. Sinonasal glomangiopericytoma: case report with emphasis on the differential diagnosis. Arch Pathol Lab Med. 2010;134:1444-9 pubmed publisher
    ..We report the case of a 48-year-old woman with epistaxis and nasal obstruction who was diagnosed with glomangiopericytoma and discuss the histologic differential diagnosis...
  19. Kabbout M, Hatoum A, Abou Lteif G, Chakroun I, Homaidan F, Darwiche N. Stage-specific effect of N-(4-hydroxyphenyl)retinamide on cell growth in squamous cell carcinogenesis. Mol Carcinog. 2004;40:12-23 pubmed
    ..HPR-induced growth suppression was accompanied by a simultaneous block in the G(1) phase of the cell cycle in RAR-transduced and control SP1 cells and differential regulation of cell cycle and apoptotic mediators...
  20. Boshoff C, Schulz T, Kennedy M, Graham A, Fisher C, Thomas A, et al. Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells. Nat Med. 1995;1:1274-8 pubmed
    ..These findings show that KSHV/HHV-8 is present in the cell types thought to represent neoplastic cells in these lesions...