peripheral nervous system neoplasms

Summary

Summary: Neoplasms which arise from peripheral nerve tissue. This includes NEUROFIBROMAS; SCHWANNOMAS; GRANULAR CELL TUMORS; and malignant peripheral NERVE SHEATH NEOPLASMS. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp1750-1)

Top Publications

  1. Wu J, Williams J, Rizvi T, Kordich J, Witte D, Meijer D, et al. Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells. Cancer Cell. 2008;13:105-16 pubmed publisher
    ..Peripheral nerve and tumors contain transiently proliferating Schwann cells that lose axonal contact, providing insight into early neurofibroma formation. We suggest that timing of Nf1 mutation is critical for neurofibroma formation...
  2. Yamamoto T, Maruyama S, Mizuno K. Schwannomatosis of the sciatic nerve. Skeletal Radiol. 2001;30:109-13 pubmed
    ..The patient underwent conservative follow-up treatment due to the minimal symptoms. The relationship of the disease with NF-2 and plexiform schwannoma is discussed...
  3. Ambros I, Hata J, Joshi V, Roald B, Dehner L, Tüchler H, et al. Morphologic features of neuroblastoma (Schwannian stroma-poor tumors) in clinically favorable and unfavorable groups. Cancer. 2002;94:1574-83 pubmed
    ..e., tumors in the neuroblastoma category...
  4. Yang S, Jin Y, Park S, Jahng T, Kim H, Chung C. Paragangliomas in the cauda equina region: clinicopathoradiologic findings in four cases. J Neurooncol. 2005;72:49-55 pubmed
    ..Although it is difficult to correctly diagnose paraganglioma preoperatively for intradural extramedullary tumors, especially in the cauda equina, paraganglioma should be included in differential diagnoses...
  5. Varin S, Faure A, Bouc P, Maugars Y, Berthelot J. Endoneural metastasis of the sciatic nerve disclosing the relapse of a renal carcinoma, four years after its surgical treatment. Joint Bone Spine. 2006;73:760-2 pubmed
    ..To report on an exceptional case of renal metastasis. Indeed, endoneural metastases of peripheral nerves are thought to be exceptional, and such an event has not yet been ascribed to a renal carcinoma...
  6. Gruber H, Glodny B, Bendix N, Tzankov A, Peer S. High-resolution ultrasound of peripheral neurogenic tumors. Eur Radiol. 2007;17:2880-8 pubmed
  7. Hughes R, Ali K, Jones H, Kendall S, Connell D. Treatment of Morton's neuroma with alcohol injection under sonographic guidance: follow-up of 101 cases. AJR Am J Roentgenol. 2007;188:1535-9 pubmed
    ..Morton's neuroma is a common cause of forefoot pain. For this study, we assessed the efficacy of a series of sonographically guided alcohol injections into the lesion...
  8. Ferner R, O Doherty M. Neurofibroma and schwannoma. Curr Opin Neurol. 2002;15:679-84 pubmed
    ..The aim of this review is to document recent advances in our understanding of the clinical characteristics and pathogenesis of neurofibromas and schwannomas in the neurofibromatoses...
  9. Baehring J, Damek D, Martin E, Betensky R, Hochberg F. Neurolymphomatosis. Neuro Oncol. 2003;5:104-15 pubmed
    ..Systemic chemotherapy was used to address the multiple potential sites of involvement. When properly treated, NL carries a prognosis similar to primary CNS lymphoma in the modern era...

More Information

Publications62

  1. Peuchmaur M, D Amore E, Joshi V, Hata J, Roald B, Dehner L, et al. Revision of the International Neuroblastoma Pathology Classification: confirmation of favorable and unfavorable prognostic subsets in ganglioneuroblastoma, nodular. Cancer. 2003;98:2274-81 pubmed
    ..Subsequently, it has been reported that GNBn can be divided into two prognostic subsets, a favorable subset (FS) and an unfavorable subset (US)...
  2. Huang J, Simon S, Nagpal S, Nelson P, Zager E. Management of patients with schwannomatosis: report of six cases and review of the literature. Surg Neurol. 2004;62:353-61; discussion 361 pubmed
  3. Gelabert Gonzalez M. Paragangliomas of the lumbar region. Report of two cases and review of the literature. J Neurosurg Spine. 2005;2:354-65 pubmed
    ..The author reports two cases of cauda equina paraganglioma (CEP) and provides a review of all previously published cases. The current radiological, neurosurgical, and pathological literature on this rare tumor is also reviewed...
  4. Karube K, Nabeshima K, Ishiguro M, Harada M, Iwasaki H. cDNA microarray analysis of cancer associated gene expression profiles in malignant peripheral nerve sheath tumours. J Clin Pathol. 2006;59:160-5 pubmed
    ..Little is known about the underlying biology of MPNST, especially the mechanisms involved in cell proliferation, invasion, or escape from apoptosis...
  5. Warrier S, Owler B, Besser M. Paraganglioma and paragangliomatosis of the cauda equina. ANZ J Surg. 2006;76:1033-7 pubmed
  6. Shimada H, Umehara S, Monobe Y, Hachitanda Y, Nakagawa A, Goto S, et al. International neuroblastoma pathology classification for prognostic evaluation of patients with peripheral neuroblastic tumors: a report from the Children's Cancer Group. Cancer. 2001;92:2451-61 pubmed
    ..The International Neuroblastoma Pathology Classification was established in 1999 for the prognostic evaluation of patients with neuroblastic tumors (NTs)...
  7. Rohaizam J, Tang I, Jong D, Tan T, Narihan M. Cervical schwannoma: report of four cases. Med J Malaysia. 2012;67:345-8 pubmed
    ..We report four cases of cervical schwannomas that we encountered at our center during four years of period. The clinical features, diagnosis and origin, management and pathological findings of these benign tumors are discussed...
  8. Williams E, Williams C, Rosson G, Heitmiller R, Dellon A. Neurectomy for treatment of intercostal neuralgia. Ann Thorac Surg. 2008;85:1766-70 pubmed publisher
    ..Experience with other painful neuromas has demonstrated that neuroma resection and muscle implantation has been effective in the upper and lower extremities. This approach was applied to patients with intercostal neuralgia...
  9. Pascual Castroviejo I, Viano J, Pascual Pascual S. [Generalized peripheral nerve tumors in neurofibromatosis type 1]. Rev Neurol. 2008;46:758-9 pubmed
  10. Mandel L, Syrop S. First-bite syndrome after parapharyngeal surgery for cervical schwannoma. J Am Dent Assoc. 2008;139:1480-3 pubmed
    ..Characteristically, inadvertent ablation of the parotid gland's sympathetic innervation results in the development of severe parotid gland-area pain at the first bite of food...
  11. Sandberg K, Nilsson J, Søe Nielsen N, Dahlin L. Tumours of peripheral nerves in the upper extremity: a 22-year epidemiological study. Scand J Plast Reconstr Surg Hand Surg. 2009;43:43-9 pubmed publisher
    ..Loss of sensation was the most common postoperative complication. However, 33/53 patients (62%) were completely free of symptoms after excision. Patients should be provided with meticulous information preoperatively...
  12. Stokvis A, Coert J, van Neck J. Insufficient pain relief after surgical neuroma treatment: Prognostic factors and central sensitisation. J Plast Reconstr Aesthet Surg. 2010;63:1538-43 pubmed publisher
    ..Patient-specific prognostic factors, predicting pain after surgical neuroma treatment, can help clinicians in the process of patient treatment and care...
  13. Czepczyński R, Guzikowska Ruszkowska I, Sowinski J. Neurolymphomatosis detected by (18)F-FDG PET/CT scan - a case report. Nucl Med Rev Cent East Eur. 2008;11:73-5 pubmed
    ..The diagnosis, based on the subsequent histopathologic lymph node examination, was diffuse large B-cell lymphoma...
  14. Sonobe S, Murakami K, Kohama M, Watanabe M, Kumabe T, Tominaga T. [C2 neurinoma with intracranial extension: a case report]. No Shinkei Geka. 2009;37:893-7 pubmed
    ..Surgical strategies with less invasiveness based on early diagnosis lead to successful recovery of neurological function...
  15. Herrera Pérez M, Oller Boix A, Pérez Lorensu P, De Bergua Domingo J, Gonzalez Casamayor S, Márquez Marfil F, et al. Intraoperative neurophysiological monitoring in peripheral nerve surgery: Technical description and experience in a centre. Rev Esp Cir Ortop Traumatol. 2015;59:266-74 pubmed publisher
    ..Intraoperative neurophysiological monitoring is a useful tool in the secondary surgery of peripheral nerve injury and the intraneural tumor pathology. ..
  16. Li C, Chang Y, Lee Y. Human pulmonary dirofilariasis coexisting with intercostal neurilemmoma: a case report and literature review. J Formos Med Assoc. 2013;112:644-7 pubmed publisher
    ..Because these diseases are self-limiting and make further treatment unnecessary, video-assisted thoracoscopic surgery (VATS) is considered preferable and less invasive for definitive diagnosis and management. ..
  17. Langerman A, Rangarajan S, Athavale S, Pham M, Sinard R, Netterville J. Tumors of the cervical sympathetic chain--diagnosis and management. Head Neck. 2013;35:930-3 pubmed publisher
    ..Tumors originating from the cervical sympathetic chain are uncommon but important entities in the differential diagnosis of parapharyngeal space masses...
  18. Wu S, Liu G, Tu R. Value of ultrasonography in neurilemmoma diagnosis: the role of round shape morphology. Med Ultrason. 2012;14:192-6 pubmed
    ..To evaluate the contribution of ultrasonography in the diagnosis of neurilemmoma and to establish if a round or round-like shape adds useful information for ultrasonographic diagnosis...
  19. Tang T, Chang H, Chuang W. Primary breast lymphoma sequentially relapsed in the peripheral and central nervous system. Acta Neurol Belg. 2012;112:271-4 pubmed publisher
    ..But no PBL with PNS relapse has been reported before. Herein, we reported a case of PBL who presented with subsequent relapse in two discrete sites of the PNS followed by the CNS...
  20. Karabatsou K, Kiehl T, Wilson D, Hendler A, Guha A. Potential role of 18fluorodeoxyglucose-positron emission tomography/computed tomography in differentiating benign neurofibroma from malignant peripheral nerve sheath tumor associated with neurofibromatosis 1. Neurosurgery. 2009;65:A160-70 pubmed publisher
    ..18FDG-PET/CT has the added advantage of fusing metabolic and anatomic imaging data sets...
  21. Omezzine S, Zaara B, Ben Ali M, Abid F, Sassi N, Hamza H. A rare cause of non discal sciatica: schwannoma of the sciatic nerve. Orthop Traumatol Surg Res. 2009;95:543-6 pubmed publisher
    ..Excision of the tumor was easily performed without neural lesioning. Histopathological examination revealed the tumor to be a schwannoma. No neurologic deficit was noted postoperatively which confirms the good prognosis of this tumor...
  22. Biagini G, Coutinho P, Jonasson T, Ueda C, Gama R. [Oncogenic osteomalacia: localization of underlying peripheral tumor with 99mTc-sestamibi scintigraphy]. Arq Bras Endocrinol Metabol. 2008;52:1505-9 pubmed
    ..In this case, 99mTc-sestamibi scintigraphy was useful in identifying the location of the tumor, which caused oncogenic osteomalacia...
  23. Stokvis A, Ruijs A, van Neck J, Coert J. Cold intolerance in surgically treated neuroma patients: a prospective follow-up study. J Hand Surg Am. 2009;34:1689-95 pubmed publisher
    ..Furthermore, we try to find predictors for cold intolerance and correlations with other symptoms...
  24. Ramani P, Nash R, Radevsky L, Patel A, Luckett M, Rogers C. VEGF-C, VEGF-D and VEGFR-3 expression in peripheral neuroblastic tumours. Histopathology. 2012;61:1006-16 pubmed publisher
  25. Aneiros Fernandez J, Arias Santiago S, Espiñeira Carmona M, Caba Molina M, Fernández Pugnaire M, O Valle F, et al. Hemangiopericytoma-like dermatofibroma with mast cells. Am J Dermatopathol. 2011;33:e74-6 pubmed publisher
    ..We present an infrequent case of dermatofibroma with a vascular pattern resembling hemangiopericytoma and the presence of abundant mast cells, which may be responsible for this vascular component...
  26. Trocchia A, Reyes A, Wilson J, Les K. A rare case of segmental neurofibromatosis involving the sciatic nerve. Am J Orthop (Belle Mead NJ). 2010;39:E42-5 pubmed
    ..Clinical, histologic, and genetic findings are given along with a brief review of the literature on segmental neurofibromatosis. Last, treatment options and postoperative care recommendations are provided...
  27. Feiden S, Sartorius E, Feiden W. [The role of diagnostic neuropathology in familial tumour syndromes]. Pathologe. 2010;31:464-70 pubmed publisher
    ..This short review discusses some of the diagnostic aspects in this field relating to neurofibromatosis type 1 and 2 (NF1, NF2), as well as the two rare tumors MBEN in Gorlin-Goltz syndrome and AT/RT in particular...
  28. Ningshu L, Min Y, Xieqiao Y, Yuanqing Y, Xiaoqiang M, Rubing L. Laparoscopic management of obturator nerve schwannomas: experiences with 6 cases and review of the literature. Surg Laparosc Endosc Percutan Tech. 2012;22:143-7 pubmed publisher
    ..To present our experiences in management of obturator nerve schwannomas by laparoscopy...
  29. Nao E, Dassonville O, Bozec A, Sudaka A, Marcy P, Vincent N, et al. Cervical sympathetic chain schwannoma. Eur Ann Otorhinolaryngol Head Neck Dis. 2012;129:51-3 pubmed publisher
    ..Cervical sympathetic chain schwannoma is rare. Following a case report, the authors describe its specific radiological and histological characteristics. Treatment is surgical...
  30. Lo Vasco V. 1p36.32 rearrangements and the role of PI-PLC ?2 in nervous tumours. J Neurooncol. 2011;103:409-16 pubmed publisher
    ..Further studies are required to verify the possible involvement of PI-PLC ?2 mutation/deletion in central nervous tumour tissues presenting abnormalities of the 1p36 chromosomal band...
  31. Al Daraji W. Granular perineurioma: the first report of a rare distinctive subtype of perineurioma. Am J Dermatopathol. 2008;30:163-8 pubmed publisher
    ..5 cm in maximum diameter) was negative for S100, but positive for NKI-C3. The morphology, immunohistochemistry, and the clinical behavior for this tumor and the differential diagnoses are discussed...
  32. Brogan D, Kakar S. Management of neuromas of the upper extremity. Hand Clin. 2013;29:409-20 pubmed publisher
    ..The choice of treatment depends in part on the nerve affected, whether it involves critical or noncritical sensation, and its location. ..
  33. Matsumoto H, Octaviana F, Terao Y, Hanajima R, Yugeta A, Hamada M, et al. Magnetic stimulation of the cauda equina in the spinal canal with a flat, large round coil. J Neurol Sci. 2009;284:46-51 pubmed publisher
    ..The MATS coil facilitates evaluation of spinal nerve conduction in the cauda equina...
  34. Gachie E, Alet J, Nguyen P, Della Volpe C, Casanova D. [Forearm osteomusculocutaneous free filet flap for arm reconstruction after amputation as an alternative to shoulder disarticulation]. Ann Chir Plast Esthet. 2015;60:148-52 pubmed publisher
    ..This procedure gave our patient a functional stump, giving back the arm functionality, especially the claw movement. ..
  35. Hung V, Dellon A. Reconstruction of a 4-cm human median nerve gap by including an autogenous nerve slice in a bioabsorbable nerve conduit: case report. J Hand Surg Am. 2008;33:313-5 pubmed publisher
  36. Winzen B, Koelsch B, Fischer C, Kindler Röhrborn A. Genetic basis of sex-specific resistance to neuro-oncogenesis in (BDIX x BDIV) F(2) rats. Mamm Genome. 2009;20:741-8 pubmed publisher
    ..By haplotype analysis Mss4 and Mss7 could be narrowed down to 20 and 12 Mb, respectively, providing a basis for the positional identification of candidate genes...
  37. Shahaf G, Reches A, Pinchuk N, Fisher T, Ben Bashat G, Kanter A, et al. Introducing a novel approach of network oriented analysis of ERPs, demonstrated on adult attention deficit hyperactivity disorder. Clin Neurophysiol. 2012;123:1568-80 pubmed publisher
    ..Introducing a network-oriented analysis method (brain network activation [BNA]) of event related potential (ERP) activities and evaluating its value in the identification and severity-grading of adult ADHD patients...
  38. Liebig C, Ayala G, Wilks J, Berger D, Albo D. Perineural invasion in cancer: a review of the literature. Cancer. 2009;115:3379-91 pubmed publisher
    ..The authors also summarized current theories on the molecular mediators and pathogenesis of PNI and introduced current research models that are leading to advancements in the understanding of this metastatic process...
  39. Gil G, Silvestre D, Tomasini N, Bussolino D, Caputto B. Controlling cytoplasmic c-Fos controls tumor growth in the peripheral and central nervous system. Neurochem Res. 2012;37:1364-71 pubmed publisher
    ..These results disclose cytoplasmic c-Fos as a new target for effectively controlling brain tumor growth...
  40. Basoglu Y, Metze D, Nashan D, Ständer S. Keratoacanthoma with perineural invasion: an indicator for aggressive behavior?. J Dtsch Dermatol Ges. 2008;6:952-5 pubmed publisher
    ..Our case suggests that perineural invasion may be an indicator for aggressive growth of head-and-neck KAs so that histologically-controlled excision is recommended...
  41. Arai Y, Nishihara M, Aono S, Ikemoto T, Suzuki C, Kinoshita A, et al. Pulsed radiofrequency treatment within brachial plexus for the management of intractable neoplastic plexopathic pain. J Anesth. 2013;27:298-301 pubmed publisher
    ..Ultrasound-guided pulsed RF was performed within the interscalene brachial plexus. During the follow-up period, their intractable pain was moderately controlled...
  42. Miller M, Palla B, Chen Q, Elashoff D, Abemayor E, St John M, et al. A novel classification system for perineural invasion in noncutaneous head and neck squamous cell carcinoma: histologic subcategories and patient outcomes. Am J Otolaryngol. 2012;33:212-5 pubmed publisher
  43. Sui X, Liu W, Guo W, Xiao F, Yu X. Precursor B-cell lymphoblastic leukemia of the arm mimicking neurogenic tumor: case report. World J Surg Oncol. 2012;10:140 pubmed publisher
    ..This kind of PBLL is similar to a peripheral nerve tumor in clinical and radiographic manifestation...
  44. Pusiol T, Zorzi M, Morichetti D, Piscioli F. Routine use of immunohisto-chemistry may increase the frequency of hybrid peripheral nerve sheath tumors. Am J Dermatopathol. 2011;33:634-6 pubmed publisher
  45. Waxweiler W, Sigmon J, Sheehan D. Adjunctive radiotherapy in the treatment of cutaneous squamous cell carcinoma with perineural invasion. J Surg Oncol. 2011;104:104-5 pubmed publisher
    ..While management typically involves excision, considerable debate exists as to the appropriate use of adjuvant radiotherapy (ART) in addition to excision. This article reviews the current relevant evidence for the use of ART...
  46. Agnew S, Dumanian G. Technical use of synthetic conduits for nerve repair. J Hand Surg Am. 2010;35:838-41 pubmed publisher
    ..A review of the technique used for conduit repair of short peripheral nerve gaps...
  47. Xu L, Liu C, Gao G, Yu X, Zhang R, Wang J. Nerve growth factor-beta expression is associated with lymph node metastasis and nerve infiltration in human hilar cholangiocarcinoma. World J Surg. 2010;34:1039-45 pubmed publisher
    ..In the present study, the expression of NGF-beta in human hilar cholangiocarcinoma and its relationship with lymphangiogenesis, lymph node metastasis, nerve infiltration, and VEGF-C expression was investigated...
  48. Spinner R, Scheithauer B, Amrami K, Wenger D, Hébert Blouin M. Adipose lesions of nerve: the need for a modified classification. J Neurosurg. 2012;116:418-31 pubmed publisher
    ..They propose an adaptation to the existing framework to illustrate the expanding spectrum of adipose lesions of nerve by considering lipomatosis and lipoma singly or in combination...
  49. Spiliopoulos K, Williams Z. Brachial plexus reconstruction following resection of a malignant peripheral nerve sheath tumor: case report. Neurosurgery. 2011;69:E245-50; discussion E250 pubmed publisher
    ..While peripheral nerve repair is commonly used in the setting of traumatic nerve injury, little is known about its potential use in the treatment of MPNST...
  50. Scheithauer B, Amrami K, Folpe A, Silva A, Edgar M, Woodruff J, et al. Synovial sarcoma of nerve. Hum Pathol. 2011;42:568-77 pubmed publisher
    ..Definitive recommendations regarding surgery and adjuvant therapies await additional reports and long-term follow-up. The literature is reviewed and a meta-analysis is performed with respect to clinicopathologic features versus outcome...
  51. Shankar G, Chen L, Kim A, Ross G, Folkerth R, Friedlander R. Composite ganglioneuroma-paraganglioma of the filum terminale. J Neurosurg Spine. 2010;12:709-13 pubmed publisher
    ..Here, the authors propose that paragangliomas at the filum terminale can revert to a neural crest cell precursor fate, giving rise to divergent neoplastic populations...
  52. Kwon J, Yoon J, Kim T, Kim H. Peripheral nerve sheath tumor of the medial plantar nerve without tarsal tunnel syndrome: a case report. J Foot Ankle Surg. 2009;48:477-82 pubmed publisher
    ..Surgeons should consider peripheral nerve sheath tumor as a cause of plantar foot pain, despite the rarity of this disorder...
  53. Prasad N, Chawla A, Lalezari S, de Ruiter G, Howe B, Amrami K, et al. A radiological classification system for intraneural vascular anomalies: assessment of potential for resection with high-resolution MRI. Acta Neurochir (Wien). 2016;158:329-34; discussion 334 pubmed publisher
    ..The anatomic framework aids surgical decision-making and ensures that all components of the lesion are considered. We advocate a multimodal approach in the treatment of these rare lesions. ..