optic nerve neoplasms

Summary

Summary: Benign and malignant neoplasms that arise from the optic nerve or its sheath. OPTIC NERVE GLIOMA is the most common histologic type. Optic nerve neoplasms tend to cause unilateral visual loss and an afferent pupillary defect and may spread via neural pathways to the brain.

Top Publications

  1. Pitz S, Becker G, Schiefer U, Wilhelm H, Jeremic B, Bamberg M, et al. Stereotactic fractionated irradiation of optic nerve sheath meningioma: a new treatment alternative. Br J Ophthalmol. 2002;86:1265-8 pubmed
    ..The authors report the outcome of the largest series of patients to date treated by stereotactic fractionated irradiation as a new treatment approach in ONSM at all stages...
  2. Tahir M, Shaikh F, Siddiqui A. Primary chiasmal sarcoid granuloma masquerading as glioma of the optic chiasm. J Coll Physicians Surg Pak. 2010;20:695-6 pubmed publisher
    ..Open biopsy of the suprasellar mass showed non-caseating chronic granulomatous inflammation compatible with sarcoidosis. Systemic features of sarcoid were absent. Patient showed marked improvement on steroid therapy...
  3. Liu G, Brodsky M, Phillips P, Belasco J, Janss A, Golden J, et al. Optic radiation involvement in optic pathway gliomas in neurofibromatosis. Am J Ophthalmol. 2004;137:407-14 pubmed
    ..Optic pathway gliomas (pilocytic astrocytomas) in neurofibromatosis type 1 (NF-1) typically involve some combination of the optic nerves, chiasm, or optic tracts. Involvement of the optic radiations is rare...
  4. Liu J, Lu Y, Raslan A, Gultekin S, Delashaw J. Cavernous malformations of the optic pathway and hypothalamus: analysis of 65 cases in the literature. Neurosurg Focus. 2010;29:E17 pubmed publisher
    ..In this study, the authors review the literature for reported cases of OPH CMs to analyze clinical and radiographic presentations as well as surgical approaches and neurological outcomes...
  5. Sitathanee C, Dhanachai M, Poonyathalang A, Tuntiyatorn L, Theerapancharoen V. Stereotactic radiation therapy for optic nerve sheath meningioma; an experience at Ramathibodi Hospital. J Med Assoc Thai. 2006;89:1665-9 pubmed
    ..To evaluate results of stereotactic radiotherapy for the treatment of optic nerve sheath meningioma (OM) at Ramathibodi Hospital...
  6. Liu J, Forman S, Hershewe G, Moorthy C, Benzil D. Optic nerve sheath meningiomas: visual improvement after stereotactic radiotherapy. Neurosurgery. 2002;50:950-5; discussion 955-7 pubmed
    ..Experience with stereotactic radiotherapy (SRT) in the treatment of ONSMs is limited because of the rare incidence of this tumor. We present a series of patients with ONSM who were treated with SRT...
  7. Arvold N, Lessell S, Bussiere M, Beaudette K, Rizzo J, Loeffler J, et al. Visual outcome and tumor control after conformal radiotherapy for patients with optic nerve sheath meningioma. Int J Radiat Oncol Biol Phys. 2009;75:1166-72 pubmed publisher
    ..Because surgical extirpation carries a high risk of postoperative blindness, vision-sparing treatment strategies are desirable...
  8. Turbin R, Thompson C, Kennerdell J, Cockerham K, Kupersmith M. A long-term visual outcome comparison in patients with optic nerve sheath meningioma managed with observation, surgery, radiotherapy, or surgery and radiotherapy. Ophthalmology. 2002;109:890-9; discussion 899-900 pubmed
    ..Comparison of treatment outcome in patients with primary optic nerve sheath meningioma (ONSM)...
  9. Becker G, Jeremic B, Pitz S, Buchgeister M, Wilhelm H, Schiefer U, et al. Stereotactic fractionated radiotherapy in patients with optic nerve sheath meningioma. Int J Radiat Oncol Biol Phys. 2002;54:1422-9 pubmed
    ..METHODS AND MARERIALS: Between 1994 and 2000, a total of 39 patients with either primary (n = 15) or secondary (n = 24) ONSM were treated with SFRT and received a median total tumor dose of 54 Gy using 1.8 Gy/fraction...

More Information

Publications62

  1. Hempelmann R, Mater E, Schroder F, Schon R. Complete resection of a cavernous haemangioma of the optic nerve, the chiasm, and the optic tract. Acta Neurochir (Wien). 2007;149:699-703; discussion 703 pubmed
    ..The vascular malformation of the optic pathways was completely removed via a pterional approach. This is the first reported instance of complete resection of a cavernoma involving the optic nerve, the chiasm, and the optic tract...
  2. Narayan S, Cornblath W, Sandler H, Elner V, Hayman J. Preliminary visual outcomes after three-dimensional conformal radiation therapy for optic nerve sheath meningioma. Int J Radiat Oncol Biol Phys. 2003;56:537-43 pubmed
    ..We assessed visual outcomes, local control, and toxicity associated with three-dimensional conformal radiation therapy (3D-CRT) for primary optic nerve sheath meningiomas (ONSM)...
  3. Bommakanti K, Panigrahi M, Yarlagadda R, Sundaram C, Uppin M, Purohit A. Optic chiasmatic-hypothalamic gliomas: is tissue diagnosis essential?. Neurol India. 2010;58:833-40 pubmed publisher
    ..Hence primary radiotherapy without histological confirmation may have deleterious consequences...
  4. Andrews D, Faroozan R, Yang B, Hudes R, Werner Wasik M, Kim S, et al. Fractionated stereotactic radiotherapy for the treatment of optic nerve sheath meningiomas: preliminary observations of 33 optic nerves in 30 patients with historical comparison to observation with or without prior surgery. Neurosurgery. 2002;51:890-902; discussion 903-4 pubmed
    ..We investigated the safety and efficacy of stereotactic radiotherapy as an alternative therapy to surgical resection for optic nerve sheath meningiomas (ONSMs)...
  5. Milker Zabel S, Huber P, Schlegel W, Debus J, Zabel du Bois A. Fractionated stereotactic radiation therapy in the management of primary optic nerve sheath meningiomas. J Neurooncol. 2009;94:419-24 pubmed publisher
    ..These data demonstrate that FSRT is an effective and safe treatment modality for local control in patients with pONSM with minimal risk of significant late toxicity...
  6. Landert M, Baumert B, Bosch M, Lütolf U, Landau K. The visual impact of fractionated stereotactic conformal radiotherapy on seven eyes with optic nerve sheath meningiomas. J Neuroophthalmol. 2005;25:86-91 pubmed
    ..Although recent studies have suggested a favorable outcome of radiotherapy, controlled data on the efficacy of fractionated stereotactic conformal radiotherapy (SCRT) in primary ONSMs are still lacking...
  7. Arai A, Morishita A, Hanada Y, Aihara H. Solitary metastatic tumor within the optic chiasm--case report. Neurol Med Chir (Tokyo). 2010;50:158-61 pubmed
  8. Baumert B, Villa S, Studer G, Mirimanoff R, Davis J, Landau K, et al. Early improvements in vision after fractionated stereotactic radiotherapy for primary optic nerve sheath meningioma. Radiother Oncol. 2004;72:169-74 pubmed
    ..To report on the efficacy and follow-up of 23 patients with primary optic nerve sheath meningioma (ONSM) with fractionated stereotactic conformal radiotherapy (SCRT)...
  9. Saeed P, Blank L, Selva D, Wolbers J, Nowak P, Geskus R, et al. Primary radiotherapy in progressive optic nerve sheath meningiomas: a long-term follow-up study. Br J Ophthalmol. 2010;94:564-8 pubmed publisher
    ..CONCLUSION Primary radiotherapy for patients with ONSM is associated with long-term improvement of visual acuity and few adverse effects...
  10. Shaikh A, Benjamin L, Kerr R. Chiasmal cavernous angioma. A rare case of progressive visual loss. Eye (Lond). 2002;16:655-7 pubmed
  11. Jeremic B, Pitz S. Primary optic nerve sheath meningioma: stereotactic fractionated radiation therapy as an emerging treatment of choice. Cancer. 2007;110:714-22 pubmed
    ..Recently, stereotactic fractionated RT (SFRT) has been introduced as a tool with better precision for RT delivery. A comprehensive review was undertaken to provide more insight into this matter...
  12. Balcer L, Liu G, Heller G, Bilaniuk L, Volpe N, Galetta S, et al. Visual loss in children with neurofibromatosis type 1 and optic pathway gliomas: relation to tumor location by magnetic resonance imaging. Am J Ophthalmol. 2001;131:442-5 pubmed
    ..To examine the potential for visual acuity loss, and its relation to extent and location of optic pathway gliomas in a cohort of children with neurofibromatosis type 1 studied with magnetic resonance imaging...
  13. Font R, Chaqués Alepuz V. [Giant optic disk melanocytoma complicated with massive intraocular seeding]. Arch Soc Esp Oftalmol. 2011;86:158-61 pubmed publisher
    ..The eye is enucleated and the pathological examination confirmed the diagnosis...
  14. Shields J, Shields C, Lavrich J. Melanocytoma of optic disk in a patient with neurofibromatosis 2. Retina. 2002;22:222-3 pubmed
  15. Diaz R, Laughlin S, Nicolin G, Buncic J, Bouffet E, Bartels U. Assessment of chemotherapeutic response in children with proptosis due to optic nerve glioma. Childs Nerv Syst. 2008;24:707-12 pubmed
    ..The radiological assessment of chemotherapeutic response in these patients can be complicated by irregular tumor shape and lack of relation between tumor volume and cosmetic effect...
  16. Panczykowski D, Piedra M, Cetas J, Delashaw J. Optochiasmatic cavernous hemangioma. Br J Neurosurg. 2010;24:301-2 pubmed publisher
    ..Subtotal resection and/or radiotherapy are not curative and can lead to hemorrhage and progressive neuronal insult. We recommend complete surgical resection as the treatment of choice...
  17. Segal L, Darvish Zargar M, Dilenge M, Ortenberg J, Polomeno R. Optic pathway gliomas in patients with neurofibromatosis type 1: follow-up of 44 patients. J AAPOS. 2010;14:155-8 pubmed publisher
    ..The aim of this study is to evaluate the clinical course of NF1 patients with OPGs at our institution with respect to visual and endocrinologic morbidity...
  18. Liu G. Optic gliomas of the anterior visual pathway. Curr Opin Ophthalmol. 2006;17:427-31 pubmed
    ..To review advances in the diagnosis and management of optic-pathway gliomas made within the past 5 years...
  19. Kelly J, Weiss A. Comparison of pattern visual-evoked potentials to perimetry in the detection of visual loss in children with optic pathway gliomas. J AAPOS. 2006;10:298-306 pubmed
    ..We sought to compare visual evoked potentials (VEPs) with standard visual field testing in children with visual pathway gliomas...
  20. Haak C, Breshears M, Lackner P. What is your diagnosis? Retrobulbar neoplasia. J Am Vet Med Assoc. 2007;231:863-4 pubmed
  21. Dinh T, Wang Y, Rosenfeld J, Cherny M. Glioblastoma of the optic chiasm. J Clin Neurosci. 2007;14:502-5 pubmed
    ..There have only been four other reports of glioblastoma multiforme arising from the optic chiasm as distinct from secondary involvement of the chiasm, in the last 40 years...
  22. Kaskel S, Muller W, Herbst E, Bock A, Hoh H. [Subacute, unilateral vision loss. Schwannoma of the orbital apex]. Ophthalmologe. 2002;99:58-9 pubmed
  23. Cappabianca P, Cinalli G, Gangemi M, Brunori A, Cavallo L, de Divitiis E, et al. Application of neuroendoscopy to intraventricular lesions. Neurosurgery. 2008;62 Suppl 2:575-97; discussion 597-8 pubmed publisher
  24. Binning M, Liu J, Kestle J, Brockmeyer D, Walker M. Optic pathway gliomas: a review. Neurosurg Focus. 2007;23:E2 pubmed
    ..Surgery is reserved for large tumors causing mass effect or hydrocephalus and tumors confined to the orbit or unilateral optic nerve...
  25. Vukovic Arar Z, Vatavuk Z, Miskic B, Janjetović Z, Sekelj S, Knežević Praveček M. Optic nerve sheath meningioma: a case report with 15-year follow-up. Semin Ophthalmol. 2014;29:52-5 pubmed publisher
    ..We present a case of a 55-year-old female with ONSM diagnosed when she was 40 years old. Diagnosis and follow-up was based on the clinical picture, CT orbit scan, and magnetic resonance imaging...
  26. Lindegaard J, Heegaard S, Toft P, Nysom K, Prause J. Malignant transformation of a medulloepithelioma of the optic nerve. Orbit. 2010;29:161-4 pubmed publisher
    ..To describe a case of malignant transformation of a medulloepithelioma of the optic nerve...
  27. Hisano M, Sakata M, Watanabe N, Kitagawa M, Murashima A, Yamaguchi K. An acromegalic woman first diagnosed in pregnancy. Arch Gynecol Obstet. 2006;274:171-3 pubmed
    ..Reports of pregnancy in acromegalic women are uncommon, numbering less than 100, in which a case of acromegaly first diagnosed in pregnancy is rare...
  28. Noval S, Contreras I, Rebolleda G, Munoz Negrete F, Ruiz de Zárate B. A comparison between Humphrey and frequency doubling perimetry for chiasmal visual field defects. Eur J Ophthalmol. 2005;15:739-45 pubmed
    ..To evaluate and compare the diagnostic ability of frequency doubling technology perimetry (FDT) with standard automated perimetry (SAP) using Humphrey Field Analyser for the detection of visual field defects produced by chiasmal lesions...
  29. Spencer A, Lee J, Prayson R. Optic nerve choristoma. Ann Diagn Pathol. 2005;9:93-5 pubmed
    ..We report a case of an optic nerve choristoma arising in a 24-year-old woman. The lesion was marked by a disordered admixture of smooth muscle tissue and optic nerve tissue. The literature on optic nerve choristoma is reviewed...
  30. Arsava E, Cikrikci B, Mocan G, Tekkok I, Kansu T. Postoperative progressive visual loss. Surv Ophthalmol. 2004;49:509-12 pubmed
    ..Mucin-positive adenocarcinoma cells were detected in the cytological examination and orbital MRI revealed metastatic infiltration of the optic chiasm and optic nerves. The primary site of the malignancy could not be established...
  31. Finger P, Natesh S, Milman T. Optical coherence tomography: pathology correlation of optic disc melanocytoma. Ophthalmology. 2010;117:114-9 pubmed publisher
    ..To correlate combined optical coherence tomography (OCT) and scanning laser ophthalmoscope (SLO) imaging to clinical and histopathologic characteristics of optic disc melanocytoma (ODM)...
  32. Zografos L, Othenin Girard C, Desjardins L, Schalenbourg A, Chamot L, Uffer S. Melanocytomas of the optic disk. Am J Ophthalmol. 2004;138:964-9 pubmed
    ..To evaluate the various forms of clinical presentation, the potential of growth, the risk of functional loss and the possibility of malignant transformation of optic disk melanocytomas in European patients...
  33. Monteiro M, Costa Cunha L, Cunha L, Malta R. Correlation between macular and retinal nerve fibre layer Fourier-domain OCT measurements and visual field loss in chiasmal compression. Eye (Lond). 2010;24:1382-90 pubmed publisher
  34. Llorente González S, Arbizu Duralde A, Pastora Salvador N. [Fractionated stereotactic radiotherapy in optic nerve sheath meningioma]. Arch Soc Esp Oftalmol. 2008;83:441-4 pubmed
    ..A 56-year-old woman with a right optic nerve sheath meningioma and visual loss, was treated with fractionated stereotactic radiotherapy. This resulted in an almost complete recovery of her visual acuity...
  35. King A, Listernick R, Charrow J, Piersall L, Gutmann D. Optic pathway gliomas in neurofibromatosis type 1: the effect of presenting symptoms on outcome. Am J Med Genet A. 2003;122A:95-9 pubmed
    ..Based on these findings, we do not advocate "baseline" MRI in children with NF1, but strongly recommend that all children of the age 10 years and younger with NF1 have complete annual ophthalmologic evaluations...
  36. Patel M, McNally L, Marr B, McCormick S, Abramson D. Primary melanoma of the optic nerve in a patient with 16-year follow up. Ophthalmic Plast Reconstr Surg. 2011;27:e69-71 pubmed publisher
    ..The authors present a case of primary melanoma of the optic nerve in a patient with no history of pigmentary disorder and 16 years of follow up...
  37. Ball B, Wetmore C, Giannini C, Wetjen N, Meyer F. Opticochiasmatic apoplexy in a five-year-old. Pediatr Neurosurg. 2011;47:279-83 pubmed publisher
    ..Timely surgery should be directed at obtaining diagnostic tissue, prevention of long-term nervous system damage and evacuation of the hematoma where feasible...
  38. Poloschek C, Lagrèze W, Ridder G, Hader C. [Clinical and neuroradiological diagnostics of orbital tumors]. Ophthalmologe. 2011;108:510-8 pubmed publisher
    ..This article illustrates the approach to a detailed clinical and neuroradiological assessment which is mandatory for the care of orbital tumor patients...
  39. Sutter C, Jean Charles A, Merle H. [Clinical and paraclinical course of melanocytoma of the optic disk. Contribution of spectral- and time-domain OCT in the study of 10 patients]. J Fr Ophtalmol. 2011;34:615-23 pubmed publisher
    ..We analyzed the clinical and paraclinical features of melanocytomas followed at the Fort-de-France University Hospital to expose and compare characteristics from new clinical imaging...
  40. Seregard S, Pelayes D, Singh A. Radiation therapy: posterior segment complications. Dev Ophthalmol. 2013;52:114-23 pubmed publisher
    ..Efficacy for any treatment still needs to be proven and, if possible, the best option by far is to minimize radiation changes to normal tissue. ..
  41. Lee J, Tobias S, Kwon J, Sade B, Kosmorsky G. Wilbrand's knee: does it exist?. Surg Neurol. 2006;66:11-7; discussion 17 pubmed
    ..We present clinical evidence that disputes the existence of Wilbrand's knee...
  42. Chaudhary R, Arora R, Mehta D, Singh M. Optical coherence tomography study of optic disc melanocytoma. Ophthalmic Surg Lasers Imaging. 2006;37:58-61 pubmed
    ..Optical coherence tomography is useful for obtaining the exact measurements of the mass lesion and may be used as a tool to follow the progress and growth pattern of the lesion...
  43. Saeed P, Rootman J, Nugent R, White V, Mackenzie I, Koornneef L. Optic nerve sheath meningiomas. Ophthalmology. 2003;110:2019-30 pubmed
    ..To study the natural history and growth of optic nerve sheath meningiomas and evaluate their management outcome...
  44. Kortmann R, Timmermann B, Taylor R, Scarzello G, Plasswilm L, Paulsen F, et al. Current and future strategies in radiotherapy of childhood low-grade glioma of the brain. Part I: Treatment modalities of radiation therapy. Strahlenther Onkol. 2003;179:509-20 pubmed
    ..Treatment of childhood low-grade gliomas is a challenging issue owing to their low incidence and the lack of consensus about "optimal" treatment approach...
  45. Lee L, Howes E, Bhisitkul R. Systemic non-Hodgkin's lymphoma with optic nerve infiltration in a patient with AIDS. Retina. 2002;22:75-9 pubmed
  46. Amoli F, Mehrabani P, Tari A. Aggressive orbital optic nerve meningioma with benign microscopic features: a case report. Orbit. 2007;26:271-4 pubmed
  47. Ozer E, Kalemci O, Yucesoy K, Canda S. Optochiasmatic cavernous angioma: unexpected diagnosis. Case report. Neurol Med Chir (Tokyo). 2007;47:128-31 pubmed
    ..Postoperatively his visual complaints remained stable, but had improved after 1 year. Optochiasmatic cavernous malformation should be treated by surgical excision, whereas biopsy is useless and may result in enlargement...
  48. Borden J. Treatment of tumors involving the optic nerves and chiasm. Semin Ophthalmol. 2002;17:22-8 pubmed
    ..Our combined microsurgical and radiosurgical approach to tumors involving the apparatus has had an excellent rate of sparing vision, a low overall morbidity and excellent success...
  49. Wabbels B, Demmler A, Seitz J, Woenckhaus M, Bloss H, Lorenz B. Unilateral adult malignant optic nerve glioma. Graefes Arch Clin Exp Ophthalmol. 2004;242:741-8 pubmed
    ..They represent a clinical entity different from the more common childhood benign optic nerve gliomas, which are frequently associated with neurofibromatosis I...
  50. Kim D, Choi J, Yang K, Jung J. Optic sheath schwannomas: report of two cases. Childs Nerv Syst. 2002;18:684-9 pubmed
    ..However, previous studies have suggested that the term 'schwannoma' should not be applied in the case of optic nerve pathology, although two cases of optic nerve sheath schwannoma have been reported to our knowledge...
  51. Besada E, Shechtman D, Barr R. Melanocytoma inducing compressive optic neuropathy: the ocular morbidity potential of an otherwise invariably benign lesion. Optometry. 2002;73:33-8 pubmed
  52. Margalit N, Barkay G, Kesler A. [Delay in diagnosis of meningiomas involving the optic apparatus: conclusions and guidelines for early imaging based on our experience in 100 patients]. Harefuah. 2013;152:135-8, 184 pubmed
    ..Pre-operative visual function is correlated with post operative visuaL results, therefore, delay in diagnosis leading to deterioration in vision may cause irreversible damage...
  53. Finger P, Harbour J, Karcioglu Z. Risk factors for metastasis in retinoblastoma. Surv Ophthalmol. 2002;47:1-16 pubmed
    ..This review has been performed to help those caring for patients with retinoblastoma and to aid informed consent...