epidural neoplasms

Summary

Summary: Neoplasms located in the space between the vertebral PERIOSTEUM and DURA MATER surrounding the SPINAL CORD. Tumors in this location are most often metastatic in origin and may cause neurologic deficits by mass effect on the spinal cord or nerve roots or by interfering with blood supply to the spinal cord.

Top Publications

  1. Kahl C, Hirt C, Decker S, Gläser D, Rohde S, Jost K, et al. Multimodal therapy for localized spinal epidural follicular lymphoma. Onkologie. 2010;33:381-4 pubmed publisher
    ..An epidural growth of low-grade lymphoma is even more unusual. Due to this low incidence, therapeutic experience for this entity is limited...
  2. Leu N, Chen C, Shy C, Lu C, Wu C, Chen D, et al. MR imaging of an infiltrating spinal epidural angiolipoma. AJNR Am J Neuroradiol. 2003;24:1008-11 pubmed
  3. Ueno H, Miyake T, Kobayashi Y, Yamada K, Uzuka Y. Epidural spinal myelolipoma in a dog. J Am Anim Hosp Assoc. 2007;43:132-5 pubmed
    ..The mass was removed and identified histopathologically as an epidural myelolipoma. Pelvic limb paresis improved after surgery, but urinary retention associated with neurological bladder dysfunction persisted...
  4. Mesfin F, Drazin D, Berry S, Homan S, Nazeer T, German J. Diffuse follicle center lymphoma of the spine: a primary epidural lymphoma?. Clin Neuropathol. 2009;28:395-9 pubmed
    ..Primary spinal follicle center lymphomas of the spine are rare with the current case being the first diffuse follicle center type reported in the literature...
  5. Petrella G, Tamburrini G, Lauriola L, Di Rocco C. Spinal epidural angiolipoma complicated by an intratumoral abscess. Case report. J Neurosurg. 2005;103:166-9 pubmed
    ..In contrast to previous descriptions, the acute onset in this case was related to a spontaneous intratumoral abscess within the tumor...
  6. Spinazzé S, Caraceni A, Schrijvers D. Epidural spinal cord compression. Crit Rev Oncol Hematol. 2005;56:397-406 pubmed
    ..Treatment options include: bed rest, administration of corticosteroids, surgery followed by radiation therapy, radiotherapy alone and, to a limited extent, chemotherapy and hormonal therapy...
  7. Gelabert Gonzalez M, Garcia Allut A. Spinal extradural angiolipoma: report of two cases and review of the literature. Eur Spine J. 2009;18:324-35 pubmed publisher
    ..The treatment for spinal extradural angiolipomas is total surgical resection and no adjuvant therapy should be administered...
  8. Samdani A, Garonzik I, Jallo G, Eberhart C, Zahos P. Spinal angiolipoma: case report and review of the literature. Acta Neurochir (Wien). 2004;146:299-302; discussion 302 pubmed
    ..In most cases complete removal is possible, however, prognosis is good even for infiltrating lesions. Thus, one must not risk neurological damage to attain complete resection...
  9. Zhong W, Huang S, Chen H, Sun H, Cai B, Liu Y, et al. Pure spinal epidural cavernous hemangioma. Acta Neurochir (Wien). 2012;154:739-45 pubmed publisher
    ..Pure epidural cavernous hemangiomas without bony involvement are rare, representing 4% of all spinal epidural tumors. Most of these are case reports and are easily misdiagnosed...

More Information

Publications62

  1. Illes A, Miltenyi Z, Miltényi L, Csécsei G, Szegedi G. Epidural involvement in Hodgkin's disease. Haematologia (Budap). 2002;32:113-9 pubmed
  2. Shin J, Lee H, Rhim S, Park S, Choi C, Suh D. Spinal epidural cavernous hemangioma: MR findings. J Comput Assist Tomogr. 2001;25:257-61 pubmed
    ..The purpose of this study was to describe the radiologic findings, focusing on the MR studies, of spinal epidural cavernous hemangiomas...
  3. Rovira A, Capellades J, Zauner M, Bella R, Rovira M. Lumbar extradural hemangiomas: report of three cases. AJNR Am J Neuroradiol. 1999;20:27-31 pubmed
  4. Thome C, Zevgaridis D, Matejic D, Sommer C, Krauss J. Juxtaposition of an epidural intraforaminal cavernous hemangioma and an intradural schwannoma. Spine (Phila Pa 1976). 2004;29:E524-7 pubmed
    ..A case of juxtaposition of a purely extradural cavernous hemangioma and an intradural schwannoma in the thoracic spine is reported...
  5. Templeton A, Hofer S, Töpfer M, Sommacal A, Fretz C, Cerny T, et al. Extraneural spread of glioblastoma--report of two cases. Onkologie. 2008;31:192-4 pubmed publisher
    ..2 years after initial diagnosis she presented with a pleural mass which was a metastasis of the formerly diagnosed glioblastoma...
  6. Weissman D. Early diagnosis of epidural metastases #62. J Palliat Med. 2006;9:480-1 pubmed
  7. Avadhani A, Shetty A, Rajasekaran S. Isolated extraosseous epidural myeloma presenting with thoracic compressive myelopathy. Spine J. 2010;10:e7-e10 pubmed publisher
    ..Multiple myeloma is the commonest primary malignancy of the spine, but it rarely presents as an extraosseous epidural tumor with only five cases reported in literature so far...
  8. Talan Hranilovic J, Vucic M, Sajko T, Bedek D, Tomic K, Lupret V. Spinal spindle cell haemangioma: an atypical location. Acta Neurochir (Wien). 2007;149:325-8; discussion 328 pubmed
    ..This lesion is uncommon and shows a predilection for distal extremities. Spindle cell haemangioma within the spine has not been previously reported in the literature...
  9. Kim D, Rosenblum J, Panghaal V, Freeman K, Lui Y. Differentiating neoplastic from nonneoplastic processes in the anterior extradural space. Radiology. 2011;260:825-30 pubmed publisher
    ..To compare neoplastic and nonneoplastic disease in the anterior extradural space (AES) with regard to the contour of the disease and the tethering of the central septum, as seen on axial magnetic resonance (MR) images...
  10. Rumboldt Z, Jednacak H, Talan Hranilovic J, Kalousek V. Spinal epidural rhabdomyosarcoma. Acta Neurochir (Wien). 2004;146:195-7 pubmed
    ..The majority of the tumor was removed surgically less than a month from the onset of symptoms. Treatment was continued with spinal irradiation and chemotherapy, however diffuse leptomeningeal metastases were found six months later...
  11. D Andrea G, Ramundo O, Trillò G, Roperto R, Isidori A, Ferrante L. Dorsal foramenal extraosseous epidural cavernous hemangioma. Neurosurg Rev. 2003;26:292-6 pubmed
  12. Chamberlain M. Neoplastic meningitis and metastatic epidural spinal cord compression. Hematol Oncol Clin North Am. 2012;26:917-31 pubmed publisher
  13. Susuki K, Matsumoto S, Kitagawa N, Shinohara H, Hasegawa O, Kuroiwa Y. Epidural compression of the cauda equina caused by vertebral osteoblastic metastasis of prostatic carcinoma: resolution by hormonal therapy. J Neurol Neurosurg Psychiatry. 2000;68:514-5 pubmed
    ..Postmyelography CT showed that the bony expansion from the vertebra had completely disappeared after treatment. This is the first report of remarkable improvement due to hormonal therapy alone...
  14. Dóczi T, Schwarcz A. Epidural mass. J Neurosurg. 2003;99:617-8; author reply 618 pubmed
  15. Bagatzounis A, Erakleous E, Michaelides I. Epidural metastasis in nasopharyngeal carcinoma. Strahlenther Onkol. 2003;179:123-8 pubmed
    ..We present the clinical course of a young patient with these two conditions and review the literature...
  16. Thakkar S, Feigen U, Mautner V. Spinal tumours in neurofibromatosis type 1: an MRI study of frequency, multiplicity and variety. Neuroradiology. 1999;41:625-9 pubmed
    ..In patients who do not satisfy the NIH criteria, it can be a helpful observation that spinal tumours in NF1 are primarily intraforaminal, extending into the spinal canal, while in NF2 they are mostly intraspinal intradural tumours...
  17. Tancioni F, Navarria P, Pessina F, Attuati L, Mancosu P, Alloisio M, et al. Assessment of prognostic factors in patients with metastatic epidural spinal cord compression (MESCC) from solid tumor after surgery plus radiotherapy: a single institution experience. Eur Spine J. 2012;21 Suppl 1:S146-8 pubmed publisher
    ..To identify potential prognostic factors predicting functional outcome and survival after surgery followed by radiotherapy for metastatic spinal cord compression due to solid tumors...
  18. Ijiri K, Yuasa S, Yone K, Matsunaga S, Ryoki Y, Taniguchi N, et al. Primary epidural hemangiopericytoma in the lumbar spine: a case report. Spine (Phila Pa 1976). 2002;27:E189-92 pubmed
    ..A case report of primary epidural hemangiopericytoma in the lumbar spine and a review of the literature are presented...
  19. Hasegawa M, Fujisawa H, Hayashi Y, Tachibana O, Kida S, Yamashita J. Surgical pathology of spinal schwannomas: a light and electron microscopic analysis of tumor capsules. Neurosurgery. 2001;49:1388-92; discussion 1392-3 pubmed
    ..Although spinal schwannomas are often encountered, the pathology of the tumor capsule has not been reported. In this study, we describe the ultrastructural pathology of the tumor capsule of spinal schwannomas...
  20. Frank B, Harrop J, Hanna A, Ratliff J. Cervical extradural meningioma: case report and literature review. J Spinal Cord Med. 2008;31:302-5 pubmed
    ..Extradural lesions are most commonly metastatic neoplasms. Extradural meningioma accounts for 2.7 to 10% of spinal neoplasms and most commonly is found in the thoracic spine...
  21. Ogawa Y, Sugawara T, Seki H, Sakuma T. Thyroid follicular carcinoma metastasized to the lung, skull, and brain 12 years after initial treatment for thyroid gland--case report. Neurol Med Chir (Tokyo). 2006;46:302-5 pubmed
    ..Intracranial metastasis of this tumor is rare, but has a mean posttreatment survival of around 12 months. Surgical excision of the metastatic intracranial lesion may be the only effective treatment...
  22. Jankowski P, Baird L, Keshavarzi S, Goolsby M, Taylor W, Nguyen A. A single spinal lesion arising from an intradural meningioma contiguous with an extradural lymphoma. J Neurosurg Spine. 2012;17:263-7 pubmed publisher
    ..The authors suggest that biopsy may be prudent in patients with known systemic lymphoma presenting with a spinal lesion that has unclear boundaries relative to the thecal sac prior to commencing radiation and chemotherapy...
  23. Caruso G, Galarza M, Borghesi I, Pozzati E, Vitale M. Acute presentation of spinal epidural cavernous angiomas: case report. Neurosurgery. 2007;60:E575-6; discussion E576 pubmed
    ..It is more common for spinal epidural cavernous angiomas to present with slow and progressive myelopathy or radiculopathy. They seldom present with clinical evidence of acute spinal cord or nerve root compression...
  24. Taillibert S, Hildebrand J. Treatment of central nervous system metastases: parenchymal, epidural, and leptomeningeal. Curr Opin Oncol. 2006;18:637-43 pubmed
    ..With prolonged survival from systemic therapies in the adjuvant and salvage setting, and because these agents cannot cross the intact blood-brain barrier, central nervous system metastases are becoming a therapeutic challenge in oncology...
  25. Mut M, Schiff D, Shaffrey M. Metastasis to nervous system: spinal epidural and intramedullary metastases. J Neurooncol. 2005;75:43-56 pubmed
    ..Intramedullary metastasis is rare but should be considered in patients with systemic malignancy and asymmetrical presentation of myelopathic symptoms. The prognosis is usually poor and preferred modality of treatment is radiotherapy...
  26. Sarikaya Seiwert S, Gierga K, Wessalowski R, Steiger H, Hänggi D. Solitary spinal epidural cavernous angiomas in children presenting with acute neurological symptoms caused by hemorrhage. J Neurosurg Pediatr. 2010;5:89-93 pubmed publisher
    ..Microsurgical resection of these cavernous malformations is an effective and curative treatment option...
  27. Kasagi S, Saegusa J, Tsuji G, Sendo S, Miura N, Hayashi H, et al. Epidural spinal tumor and periaortitis as rare complications of Wegener's granulomatosis. Mod Rheumatol. 2011;21:678-83 pubmed publisher
    ..We discuss the differential diagnosis in this patient, and the association of MPO-ANCA with periaortitis or epidural spinal tumor...
  28. Demir M, Ozdemir H, Unlu E, Temizoz O, Genchellac H. Differential diagnosis of spinal epidural meningioma and hemangioma at MR imaging. Radiology. 2007;244:933; author reply 933-4 pubmed
  29. Jibia A, N Dri O, Sissoko D, Derou L, Broalet E, Varlet G, et al. [Metastatic epiduritis in neurosurgery: Hospital data from the Abidjan teaching hospital, 2007-2012]. Med Sante Trop. 2016;26:57-63 pubmed publisher
    ..Although neurosurgery is essential to its management, the exact role of this discipline in the treatment of spinal cancer in sub-Saharan Africa has not yet been assessed...
  30. Gerber D, Grossman S. Does decompressive surgery improve outcome in patients with metastatic epidural spinal-cord compression?. Nat Clin Pract Neurol. 2006;2:10-1 pubmed
  31. Akhaddar A, Gazzaz M, Derraz S, Rifi L, Amarti A, Aghzadi A, et al. [Spinal epidural angiolipomas: a rare cause of spinal cord compression. A report of 8 cases and review of the literature]. Neurochirurgie. 2000;46:523-533 pubmed
    ..The surgical removal often easy of the epidural spinal angiolipomas permit a fast recovery. The etiopathogenesis of this process is still controversial between the dysembryogenetic and malformative hypothesis...
  32. Suh S, Seol H, Hong S, Kim J, Kim J, Lee J, et al. Spinal epidural synovial sarcoma: a case of homogeneous enhancing large paravertebral mass on MR imaging. AJNR Am J Neuroradiol. 2005;26:2402-5 pubmed
    ..The mass was relatively homogeneous, hyperintense to muscle and isointense to fat on T2-weighted images, and isointense to muscle on T1-weighted images, and it demonstrated moderate homogeneous enhancement...
  33. Runge V, Lee C, Iten A, Williams N. Contrast-enhanced magnetic resonance imaging in a spinal epidural tumor model. Invest Radiol. 1997;32:589-95 pubmed
    ..High-resolution MR images were acquired both before and after intravenous gadolinium chelate injection, assessing lesion detectability and efficacy of imaging technique...
  34. Thomas K, Nosyk B, Fisher C, Dvorak M, Patchell R, Regine W, et al. Cost-effectiveness of surgery plus radiotherapy versus radiotherapy alone for metastatic epidural spinal cord compression. Int J Radiat Oncol Biol Phys. 2006;66:1212-8 pubmed
    ..The current study compared the cost-effectiveness of the two approaches...
  35. Rekha W, Pramesh S, Maheshwari A, Kerkar R, Tongaonkar H. Malignant gestational trophoblastic disease presenting as extradural mass. Aust N Z J Obstet Gynaecol. 2003;43:393-4 pubmed
  36. Klimo P, Thompson C, Kestle J, Schmidt M. A meta-analysis of surgery versus conventional radiotherapy for the treatment of metastatic spinal epidural disease. Neuro Oncol. 2005;7:64-76 pubmed
    ..Neurologic status, overall health, extent of disease (spinal and extraspinal), and primary pathology all impact proper treatment selection...
  37. Yurt A, Arda M, Vardar E. Metastatic pheochromocytoma of the thoracic spinal extradural space. Case report and review of the literature. Kobe J Med Sci. 2005;51:49-53 pubmed
    ..This is the first case report of an epidural metastasis from malignant pheochromocytoma without a bony invasion...
  38. Arana E, Kovacs F, Royuela A, Asenjo B, Perez Ramirez U, Zamora J. Agreement in Metastatic Spinal Cord Compression. J Natl Compr Canc Netw. 2016;14:70-6 pubmed
    ..Metastatic epidural spinal cord compression (ESCC) is a devastating medical emergency. The purpose of this study was to determine the reliability of the 6-point ESCC scoring system and the identification of the spinal level presenting ESCC...
  39. Malani A, Gupta C, Weigand R, Gupta V, Rangineni G. Spinal Burkitt's lymphoma in adults. Clin Lymphoma Myeloma. 2006;6:333-6 pubmed
    ..We also present a review of the literature for the etiology and clinical features of other spinal lymphomas and Burkitt's lymphoma involving the spine in adults...
  40. Shimony J, Gilula L, Zeller A, Brown D. Percutaneous vertebroplasty for malignant compression fractures with epidural involvement. Radiology. 2004;232:846-53 pubmed
    ..To evaluate safety and effectiveness of performance of percutaneous vertebroplasty (PVP) in patients with malignant compression fractures and involvement of the epidural space...
  41. Saito T, Terada K, Tsuchiya K, Oda Y, Tsuneyoshi M, Iwamoto Y. Lymphangioma presenting as a dumbbell tumor in the epidural space of the lumbar spine. Spine (Phila Pa 1976). 1999;24:74-6 pubmed
    ..A case report...
  42. Byrne T. Metastatic epidural cord compression. Curr Neurol Neurosci Rep. 2004;4:191-5 pubmed
    ..In addition, a new study demonstrates that the time to develop motor weakness is an independent prognostic factor in outcome in patients with MESCC. These advances are reviewed...
  43. Tekaya R, Hamdi W, Azzouz D, Bouaziz M, Jaafoura M, Ladeb M, et al. [Cervicobrachial neuralgia revealing neurosarcoma]. Rev Neurol (Paris). 2008;164:82-6 pubmed publisher
    ..The physical examination found a mass on the left side of the neck. Plain radiographs showed osteoarthritis. MRI showed a well-defined paravertebral mass. Pathologic diagnosis was neurosarcoma. Radiotherapy was delivered...
  44. Daley M, Partington M, Kadan Lottick N, Odom L. Primary epidural burkitt lymphoma in a child: case presentation and literature review. Pediatr Hematol Oncol. 2003;20:333-8 pubmed
    ..The authors present a 13-year-old female with isolated epidural Burkitt lymphoma with favorable outcome, and review the pediatric literature...
  45. Is M, Gezen F, Alper M, Yildiz H, Akyuz F. Epidural extension of a lumbar vertebral haemangioma. J Clin Neurosci. 2006;13:687-90 pubmed
    ..Vertebral haemangioma must be considered when there is evidence of a vertebral corpus lesion with epidural extension on magnetic resonance imaging...
  46. McGirt M, Gok B, Shepherd S, Noggle J, Garces Ambrossi G, Bydon A, et al. Effect of hyperglycemia on progressive paraparesis in a rat etastatic spinal tumor model. J Neurosurg Spine. 2009;10:9-15 pubmed publisher
    ..The goal in this study was to determine whether experimentally induced hyperglycemia accelerates neurological decline in an established animal model of MESCC...
  47. Salzburg J, Burkhardt B, Zimmermann M, Wachowski O, Woessmann W, Oschlies I, et al. Prevalence, clinical pattern, and outcome of CNS involvement in childhood and adolescent non-Hodgkin's lymphoma differ by non-Hodgkin's lymphoma subtype: a Berlin-Frankfurt-Munster Group Report. J Clin Oncol. 2007;25:3915-22 pubmed
  48. Zaidat O, Ruff R. Treatment of spinal epidural metastasis improves patient survival and functional state. Neurology. 2002;58:1360-6 pubmed
    ..To determine factors affecting the success of radiation therapy (RT) of spinal epidural metastases and patient survival after RT...
  49. Gottschalk A, Bischoff P, Lamszus K, Standl T. Epidural hematoma after spinal anesthesia in a patient with undiagnosed epidural lymphoma. Anesth Analg. 2004;98:1181-3, table of contents pubmed
    ..Pathological examination of the hematoma revealed a highly vascularized centroblastic non-Hodgkin's lymphoma that was not diagnosed before surgery. The patient did not develop any neurological deficits...
  50. Benzagmout M, Azzal F, Bitar A, El Faïz Chaoui M, Van Effenterre R. Cervical spinal extradural meningioma: Case report. Neurochirurgie. 2010;56:401-3 pubmed publisher
    ..The surgical removal of the tumor was incomplete because of the deep lateral extension of the lesion...
  51. Farin A, Aryan H, Abshire B. Thymoma metastatic to the extradural spine. J Clin Neurosci. 2005;12:824-7 pubmed
    ..Spinal metastasis is exceptionally rare. We present a case of thymoma with extradural metastasis and discuss the relevant literature...
  52. Feng J, Xu Y, Li L, Yang R, Ye X, Zhang N, et al. MRI diagnosis and preoperative evaluation for pure epidural cavernous hemangiomas. Neuroradiology. 2009;51:741-7 pubmed publisher
    ..The aims of the study were to summarize the characteristics of the spinal epidural cavernous hemangioma, especially for the MRI, and to improve the accurate rate of the preoperative diagnosis...
  53. Liu S, Liu Y, Li D, Fan H, Huai J, Guo J, et al. [Relationship of motor deficits and imaging features in metastatic epidural spinal cord compression]. Zhonghua Yi Xue Za Zhi. 2010;90:1606-8 pubmed
    ..To explore the relationship of motor deficits of the lower extremities with the imaging features of malignant spinal cord compression (MESCCs)...