infratentorial neoplasms

Summary

Summary: Intracranial tumors originating in the region of the brain inferior to the tentorium cerebelli, which contains the cerebellum, fourth ventricle, cerebellopontine angle, brain stem, and related structures. Primary tumors of this region are more frequent in children, and may present with ATAXIA; CRANIAL NERVE DISEASES; vomiting; HEADACHE; HYDROCEPHALUS; or other signs of neurologic dysfunction. Relatively frequent histologic subtypes include TERATOMA; MEDULLOBLASTOMA; GLIOBLASTOMA; ASTROCYTOMA; EPENDYMOMA; CRANIOPHARYNGIOMA; and choroid plexus papilloma (PAPILLOMA, CHOROID PLEXUS).

Top Publications

  1. Spiegler B, Bouffet E, Greenberg M, Rutka J, Mabbott D. Change in neurocognitive functioning after treatment with cranial radiation in childhood. J Clin Oncol. 2004;22:706-13 pubmed
    ..To evaluate the pattern of stability and change over time across multiple domains of neurocognitive function in radiated survivors of posterior fossa (PF) tumors...
  2. Sharma M, Mansur D, Reifenberger G, Perry A, Leonard J, Aldape K, et al. Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin. Cancer Res. 2007;67:890-900 pubmed
    ..These results suggest that glial tumors share an intrinsic, lineage-specific molecular signature that reflects the brain region in which their nonmalignant predecessors originated...
  3. Sandberg D, Crandall K, Koru Sengul T, Padgett K, Landrum J, Babino D, et al. Pharmacokinetic analysis of etoposide distribution after administration directly into the fourth ventricle in a piglet model. J Neurooncol. 2010;97:25-32 pubmed publisher
    ..Etoposide does not distribute evenly throughout CSF spaces after administration into the fourth ventricle, and higher peak CSF levels are observed in the fourth ventricle than in the lumbar cistern...
  4. Kieffer Renaux V, Viguier D, Raquin M, Laurent Vannier A, Habrand J, Dellatolas G, et al. Therapeutic schedules influence the pattern of intellectual decline after irradiation of posterior fossa tumors. Pediatr Blood Cancer. 2005;45:814-9 pubmed
    ..To evaluate intellectual decline in children with posterior fossa (PF) tumors treated with different therapeutic protocols...
  5. Merchant T, Lee H, Zhu J, Xiong X, Wheeler G, Phipps S, et al. The effects of hydrocephalus on intelligence quotient in children with localized infratentorial ependymoma before and after focal radiation therapy. J Neurosurg. 2004;101:159-68 pubmed
    ..The goal of this study was to determine the influence of hydrocephalus on intelligence quotient (IQ) in children with infratentorial ependymoma before and after the administration of focal radiation...
  6. Grill J, Viguier D, Kieffer V, Bulteau C, Sainte Rose C, Hartmann O, et al. Critical risk factors for intellectual impairment in children with posterior fossa tumors: the role of cerebellar damage. J Neurosurg. 2004;101:152-8 pubmed
    ..The authors studied the effects in 76 children treated for a malignant posterior fossa tumor in a cross-sectional study...
  7. Masui K, Kawai S, Yonezawa T, Fujimoto K, Nishi N. Intradural retroclival chordoma without bone involvement - case report. Neurol Med Chir (Tokyo). 2006;46:552-5 pubmed
    ..Specialized skull base techniques should be used instead of conventional surgical approaches for intradural skull base chordoma...
  8. Linkov G, Morris L, Shah J, Kraus D. First bite syndrome: incidence, risk factors, treatment, and outcomes. Laryngoscope. 2012;122:1773-8 pubmed publisher
    ..The incidence, risk factors, treatment options, and outcomes of FBS are poorly understood. We hypothesized that certain clinical and tumor variables independently predict the development of FBS...
  9. Konopka W, Olszewski J. [Central vertigo of posterior cranial fossa tumors origin]. Otolaryngol Pol. 2008;62:291-4 pubmed publisher
    ..Usually they are due to benign or malignant tumors. The aim of our study was to present the cases of the patients with central vertigo attended to the Otorhinolaryngology emergency department of the University Hospital...

More Information

Publications62

  1. Casado Picón R, Fernández López M, Lumbreras Fernández J. [Torticollis as an initial sign of posterior fossa tumor: case of child with pilocytic astrocytoma]. An Pediatr (Barc). 2008;68:312-3 pubmed
  2. Robinson K, Fraley C, Pearson M, Kuttesch J, Compas B. Neurocognitive late effects of pediatric brain tumors of the posterior fossa: a quantitative review. J Int Neuropsychol Soc. 2013;19:44-53 pubmed publisher
  3. Miralbell R, Fitzgerald T, Laurie F, Kessel S, Glicksman A, Friedman H, et al. Radiotherapy in pediatric medulloblastoma: quality assessment of Pediatric Oncology Group Trial 9031. Int J Radiat Oncol Biol Phys. 2006;64:1325-30 pubmed
    ..To evaluate the potential influence of radiotherapy quality on survival in high-risk pediatric medulloblastoma patients...
  4. Hermann E, Rittierodt M, Krauss J. Combined transventricular and supracerebellar infratentorial approach preserving the vermis in giant pediatric posterior fossa midline tumors. Neurosurgery. 2008;63:ONS30-5; discussion ONS35-7 pubmed publisher
    ..Here, we present our combined transventricular and supracerebellar infratentorial approach to avoid complications of vermian splitting...
  5. Fagundes Pereyra W, de Sousa L, Carvalho G, Pittella J, de Sousa A. Meningeal melanocytoma of the posterior fossa: case report and literature review. Surg Neurol. 2005;63:269-73; discussion 273-4 pubmed
    ..Some aspects related to diagnosis, radiological appearance, histopathologic features, and management are discussed in this paper...
  6. Vagner Capodano A, Zattara Cannoni H, Quilichini B, Giocanti G. [From cytogenetics to cytogenomics of brain tumors: 1. Medulloblastoma]. Bull Cancer. 2003;90:315-8 pubmed
    ..We present data provided by recent studies on conventional cytogenetic, molecular cytogenetic and molecular genetic in correlation with prognosis in these tumors...
  7. Treasure T, Dean J, Gear R. Craniofacial approaches and reconstruction in skull base surgery: techniques for the oral and maxillofacial surgeon. J Oral Maxillofac Surg. 2013;71:2137-50 pubmed publisher
    ..Oral and maxillofacial surgeons frequently perform elective facial osteotomies and treat victims of cranial base trauma. These same principles can be applied to SBS as a part of the skull base team. ..
  8. Martínez Lage J, Salcedo C, Corral M, Poza M. Medulloblastomas in neurofibromatosis type 1. Case report and literature review. Neurocirugia (Astur). 2002;13:128-31 pubmed
    ..We propose that medulloblastoma should be added to the list of malignancies that are apt to occur in NF-1...
  9. Butler W, Khan A, Khan S. Posterior fossa ependymoma with intense but transient disseminated enhancement but not metastasis. Pediatr Neurosurg. 2002;37:27-31 pubmed
    ..However, we terminated this treatment after realizing that the bulk of the clinical evidence refuted the diagnosis of metastatic disease...
  10. Pan C, Kuo M, Hsieh S. Auditory agnosia caused by a tectal germinoma. Neurology. 2004;63:2387-9 pubmed
    ..Inferior colliculus may play a role in the analysis of sound properties...
  11. Colli B, Assirati J, Deriggi D, Neder L, dos Santos A, Carlotti C. Tentorial meningiomas: follow-up review. Neurosurg Rev. 2008;31:421-30; discussion 430 pubmed publisher
    ..Prognostic factors for recurrence were histopathologic grade III and subtotal resection. Radical resection allowed better results. Nevertheless, subtotal resection may be acceptable for cases with cranial nerves or sinuses invasions...
  12. Sanverdi S, Oguz K, Haliloglu G. Hypertrophic olivary degeneration in children: four new cases and a review of the literature with an emphasis on the MRI findings. Br J Radiol. 2012;85:511-6 pubmed publisher
    ..We present the clinical and MRI findings of four new paediatric cases with HOD. Three of the patients had a posterior fossa surgery, and one did not have an identifiable cause...
  13. Zhu W, Mao Y, Zhou L, Zhang R, Chen L. Combined subtemporal and retrosigmoid keyhole approach for extensive petroclival meningioma surgery: report of experience with 7 cases. Minim Invasive Neurosurg. 2007;50:106-10 pubmed
    ..Our experience of 7 cases using a combined subtemporal and retrosigmoid keyhole approach surgery was evaluated for the treatment of extensive petroclival meningiomas...
  14. Wolfe K, Madan Swain A, Hunter G, Reddy A, Baños J, Kana R. An fMRI investigation of working memory and its relationship with cardiorespiratory fitness in pediatric posterior fossa tumor survivors who received cranial radiation therapy. Pediatr Blood Cancer. 2013;60:669-75 pubmed publisher
    ..This population is known to show executive dysfunction and lower rates of aerobic exercise compared to peers...
  15. Santi M, Quezado M, Ronchetti R, Rushing E. Analysis of chromosome 7 in adult and pediatric ependymomas using chromogenic in situ hybridization. J Neurooncol. 2005;72:25-8 pubmed
    ..These results encourage further investigations with CISH on a larger scale to determine its merit as an ancillary diagnostic and prognostic tool...
  16. Bhatia R, Tahir M, Chandler C. The management of hydrocephalus in children with posterior fossa tumours: the role of pre-resectional endoscopic third ventriculostomy. Pediatr Neurosurg. 2009;45:186-91 pubmed publisher
  17. Donahue S, Itharat P. A-pattern strabismus with overdepression in adduction: a special type of bilateral skew deviation?. J AAPOS. 2010;14:42-6 pubmed publisher
  18. Ishigaki D, Arai H, Sasoh M, Ogasawara K, Uesugi N, Sugai T, et al. Meningioma in the posterior fossa without dural attachment. Neurol Med Chir (Tokyo). 2007;47:364-6 pubmed
    ..Histological and immunohistochemical studies established the diagnosis of meningothelial meningioma (World Health Organization grade I)...
  19. Mascelli S, Barla A, Raso A, Mosci S, Nozza P, Biassoni R, et al. Molecular fingerprinting reflects different histotypes and brain region in low grade gliomas. BMC Cancer. 2013;13:387 pubmed publisher
    ..Indeed, tumours containing both neoplastic ganglion and astrocytic cells occur at a lower frequency...
  20. Gnanalingham K, Lafuente J, Thompson D, Harkness W, Hayward R. Surgical procedures for posterior fossa tumors in children: does craniotomy lead to fewer complications than craniectomy?. J Neurosurg. 2002;97:821-6 pubmed
    ..The authors compared the postoperative complications of craniectomies and craniotomies in children with posterior fossa tumors...
  21. Albayram S, Urger E, Oz B, Kafadar A, Islak C, Kocer N. MR Imaging of pial melanosis secondary to a posterior fossa melanotic ependymoma. AJNR Am J Neuroradiol. 2005;26:804-8 pubmed
    ..There was no evidence of hemosiderin in tumor cells and in interstitial spaces. Pial melanin accumulation secondary to a posterior fossa melanotic ependymoma explained our MR findings...
  22. Morelli D, Pirotte B, Lubansu A, Detemmerman D, Aeby A, Fricx C, et al. Persistent hydrocephalus after early surgical management of posterior fossa tumors in children: is routine preoperative endoscopic third ventriculostomy justified?. J Neurosurg. 2005;103:247-52 pubmed
    ..The authors evaluate the incidence of persistent hydrocephalus after early surgical management of pediatric posterior fossa tumors and the indicators for routine preoperative endoscopic third ventriculostomy (ETV)...
  23. Chen M, Wu M, Zhou L, Duan L, Li P, Xu J, et al. [The clinical features and perioperational managements of craniopharyngiomas in posterior fossa]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2011;42:730-2, 744 pubmed
    ..To investigate the clinical features and perioperational managements of craniophayngiomas located in posterior fossa...
  24. Boguszewicz L, Blamek S, Sokół M. Pattern recognition methods in (1)H MRS monitoring in vivo of normal appearing cerebellar tissue after treatment of posterior fossa tumors. Acta Neurochir Suppl. 2010;106:171-5 pubmed publisher
    ..Pattern recognition methods coupled with MRS revealed significant treatment-dependent alterations in normal appearing cerebellar tissue, as well as metabolic changes induced by tumor progression/recurrence...
  25. Poretti A, Meoded A, Huisman T. Neuroimaging of pediatric posterior fossa tumors including review of the literature. J Magn Reson Imaging. 2012;35:32-47 pubmed publisher
    ..In this review the conventional neuroimaging findings, as well as the DWI, and DTI characteristics of common pediatric posterior fossa tumors are discussed and summarized...
  26. Merchant T. Three-dimensional conformal radiation therapy for ependymoma. Childs Nerv Syst. 2009;25:1261-8 pubmed publisher
    ..These advances occurred at a time when clinical trial results confirmed that radiotherapy avoidance strategies were unsuccessful...
  27. Chi S, Zimmerman M, Yao X, Cohen K, Burger P, Biegel J, et al. Intensive multimodality treatment for children with newly diagnosed CNS atypical teratoid rhabdoid tumor. J Clin Oncol. 2009;27:385-9 pubmed publisher
    ..Based on a previous pilot series, a prospective multi-institutional trial was conducted for patients with newly diagnosed CNS ATRT...
  28. Neufeld S, Dundon B, Yu H, Newburn Cook C, Drummond J. Midline location of tumour is a risk factor for postoperative vomiting in children requiring posterior fossa tumour resection. Can J Neurosci Nurs. 2009;31:10-4 pubmed
    ..The development of clinical practice guidelines and further research to study the effectiveness of novel, multimodal antiemetic therapies are required for this patient population...
  29. Wootton M, Lockie J. Anaesthetic management of a child with a positive family history of malignant hyperthermia for posterior fossa surgery in the sitting position. Paediatr Anaesth. 2001;11:498-500 pubmed
    ..A nontriggering anaesthetic was therefore planned using infusions of propofol and remifentanil and a vapour free anaesthetic system delivering an oxygen/air mixture. The surgery was carried out with the child in the sitting position...
  30. Huber J, Bradley K, Spiegler B, Dennis M. Long-term neuromotor speech deficits in survivors of childhood posterior fossa tumors: effects of tumor type, radiation, age at diagnosis, and survival years. J Child Neurol. 2007;22:848-54 pubmed
    ..Dysfluent and slow speech occur in cerebellar tumor survivors, regardless of tumor type and radiation history. Cerebellar tumors in childhood limit speech rate in adulthood...
  31. Stettner G, Rostasy K, Ludwig H, Merkler D, Fahsold R, Gartner J. Infratentorial meningioma in an 8-year-old child as first sign of neurofibromatosis type 2. Neuropediatrics. 2007;38:29-31 pubmed
    ..Our patient demonstrates the need for molecular testing for NF2 gene mutations even in isolated childhood meningiomas although they do not fulfill the clinical criteria of NF2...
  32. Berger A, Sadeh M, Tzur G, Shuper A, Kornreich L, Inbar D, et al. Task switching after cerebellar damage. Neuropsychology. 2005;19:362-370 pubmed publisher
    ..Berger et al., in press). They have important implications for our understanding of the cognitive sequelae of early cerebellar damage as well as the involvement of the cerebellum in task switching...
  33. Jaing T, Wang H, Tsay P, Tseng C, Jung S, Lin K, et al. Multivariate analysis of clinical prognostic factors in children with intracranial ependymomas. J Neurooncol. 2004;68:255-61 pubmed
    ..Failure at the primary site is the major obstacle to improve cure rates. The extent of surgical resection and age were the only statistically significant prognostic factors...
  34. Steinlin M, Imfeld S, Zulauf P, Boltshauser E, Lövblad K, Ridolfi Lüthy A, et al. Neuropsychological long-term sequelae after posterior fossa tumour resection during childhood. Brain. 2003;126:1998-2008 pubmed
  35. Shimbo Y, Sakata M, Hayano M, Mori S. Topographical relationships between the brainstem auditory and somatosensory evoked potentials and the location of lesions in posterior fossa stroke. Neurol Med Chir (Tokyo). 2003;43:282-91; discussion 292 pubmed
  36. Mabbott D, Snyder J, Penkman L, Witol A. The effects of treatment for posterior fossa brain tumors on selective attention. J Int Neuropsychol Soc. 2009;15:205-16 pubmed publisher
    ..These findings help to elucidate the potential impact of pediatric brain tumors and their treatment on discrete attentional skills...
  37. Kerr E, Borys E, Bobinski M, Shahlaie K. Posterior fossa calcifying pseudoneoplasm of the central nervous system. J Neurosurg. 2013;118:896-902 pubmed publisher
    ..Their findings suggest that these lesions may sometimes behave in a more aggressive manner than commonly thought...
  38. Pirris S, Pollack I, Snyderman C, Carrau R, Spiro R, Tyler Kabara E, et al. Corridor surgery: the current paradigm for skull base surgery. Childs Nerv Syst. 2007;23:377-84 pubmed
    ..In this report, we present the case of a 3-year-old boy who was found to have a large posterior pharyngeal, clival, and posterior fossa tumor detected on a CT scan after a closed head injury...
  39. Muzumdar D. Posterior fossa tumor presenting as a giant macrocranium in an infant. Pediatr Neurosurg. 2005;41:224-5 pubmed
  40. Litrico S, Desjardins T, Dran G, Michiels J, Paquis P. [Infratentorial localisation of a dysembryoplastic neuroepithelial tumor. A case report]. Neurochirurgie. 2004;50:47-52 pubmed
    ..We discuss the clinical and radiological particularities of this infratentorial location and compare our case with those previously described in the literature...
  41. Cata J, Saager L, Kurz A, Avitsian R. Successful extubation in the operating room after infratentorial craniotomy: the Cleveland Clinic experience. J Neurosurg Anesthesiol. 2011;23:25-9 pubmed publisher
    ..This retrospective analysis assessed the rate of successful extubation after infratentorial craniotomy in a tertiary hospital...
  42. Ildan F, Tuna M, Erman T, Göçer A, Zeren M, Cetinalp E. The evaluation and comparison of cerebellar mutism in children and adults after posterior fossa surgery: report of two adult cases and review of the literature. Acta Neurochir (Wien). 2002;144:463-73 pubmed
  43. Oh S, Lee D, Suh Y, Lee J. Heterotopic glioneuronal mass of the cerebellomedullary cistern with duct cyst formation of ectopic salivary gland tissue. Neuropathology. 2013;33:179-84 pubmed publisher
    ..The cystic portion of the mass was a duct cyst of the salivary gland. The pathogenesis of this case with heterotopic glioneuronal, salivary and adipose tissues remains unclear...
  44. Carroll C, Watson P, Spoudeas H, Hawkins M, Walker D, Clare I, et al. Prevalence, associations, and predictors of apathy in adult survivors of infantile (<5 years of age) posterior fossa brain tumors. Neuro Oncol. 2013;15:497-505 pubmed publisher
    ..In this study, our objective was to examine prevalence, associations, and predictors of apathy in adult survivors of an infantile posterior fossa brain tumor (PFT)...
  45. Nanda R, Ganju R, Schreibmann E, Chen Z, Zhang C, Jegadeesh N, et al. Correlation of Acute and Late Brainstem Toxicities With Dose-Volume Data for Pediatric Patients With Posterior Fossa Malignancies. Int J Radiat Oncol Biol Phys. 2017;98:360-366 pubmed publisher
    ..Additional work investigating inherent biologic sensitivity might also provide further insight into this clinical problem. ..
  46. Ahmed S, Iftekharuddin K, Vossough A. Efficacy of texture, shape, and intensity feature fusion for posterior-fossa tumor segmentation in MRI. IEEE Trans Inf Technol Biomed. 2011;15:206-13 pubmed publisher
    ..We use different similarity metrics to evaluate quality and robustness of these selected features for PF tumor segmentation in MRI for ten pediatric patients...
  47. Alexiou G, Tsiouris S, Voulgaris S, Doukas M, Goussia A, Kyritsis A, et al. Brain scintigraphy with 99mTc-tetrofosmin for the differential diagnosis of a posterior fossa tumor. Hell J Nucl Med. 2008;11:114-7 pubmed
    ..The patient underwent surgery and haemangioblastoma was confirmed by histology. Differential diagnosis is discussed. (99m)Tc-tetrofosmin scintiscan contributed to diagnostic information...
  48. Rushing E, Cooper P, Quezado M, Begnami M, Crespo A, Smirniotopoulos J, et al. Subependymoma revisited: clinicopathological evaluation of 83 cases. J Neurooncol. 2007;85:297-305 pubmed
    ..Subependymomas are rare ependymal neoplasms. To date, a large clinicopathologic study of these benign neoplasms treated with modern neurosurgical techniques has not been reported...
  49. Extremera V, Alvarez Coca J, Rodríguez G, Pérez J, de Villanueva J, Díaz C. Torticollis is a usual symptom in posterior fossa tumors. Eur J Pediatr. 2008;167:249-50 pubmed
  50. Lam C, Hall W, Truwit C, Liu H. Intra-operative MRI-guided approaches to the pediatric posterior fossa tumors. Pediatr Neurosurg. 2001;34:295-300 pubmed
    ..MRI-guided surgery allows for real time interaction between imaging and the neurosurgeon, not permitted by frameless stereotaxy, and with higher resolution than ultrasound or CT...
  51. Raghunath A, Indira Devi B, Bhat D, Somanna S. Dermoid cysts of the posterior fossa--morbid associations of a benign lesion. Br J Neurosurg. 2013;27:765-71 pubmed publisher
    ..Despite the morbid presentation with severe life-threatening complications, the overall outcome was excellent. Implications of the various associations are discussed...
  52. Warmuth Metz M, Kuhl J, Rutkowski S, Krauss J, Solymosi L. [Differential infratentorial brain tumor diagnosis in children]. Radiologe. 2003;43:977-85 pubmed
    ..The natural history of the most frequent tumors and its importance for treatment decisions is discussed in light of the literature...
  53. Distel L, Neubauer S, Varon R, Holter W, Grabenbauer G. Fatal toxicity following radio- and chemotherapy of medulloblastoma in a child with unrecognized Nijmegen breakage syndrome. Med Pediatr Oncol. 2003;41:44-8 pubmed
    ..Several hereditary disorders including immunodeficiency (ID) syndromes or repair disorders, Ataxia Telangiectasia (AT), and Nijmegen breakage syndrome (NBS) were associated with an elevated risk for severe treatment related toxicity...