nervous system neoplasms


Summary: Benign and malignant neoplastic processes arising from or involving components of the central, peripheral, and autonomic nervous systems, cranial nerves, and meninges. Included in this category are primary and metastatic nervous system neoplasms.

Top Publications

  1. Mukerji I, Ramkissoon S, Reddy K, Rameshwar P. Autocrine proliferation of neuroblastoma cells is partly mediated through neurokinin receptors: relevance to bone marrow metastasis. J Neurooncol. 2005;71:91-8 pubmed
    ..The results show potential roles for NK receptors in the proliferation of NB. ..
  2. Hemminki K, Li X. Familial risks in nervous system tumors. Cancer Epidemiol Biomarkers Prev. 2003;12:1137-42 pubmed
    ..Yet, it is likely that many brain astrocytoma, meningioma, and mixed families represent yet unknown heritable conditions...
  3. Schwab M. MYCN in neuronal tumours. Cancer Lett. 2004;204:179-87 pubmed
    ..Identification of amplified MYCN in neuroblastomas has marked the clinical debut of oncogenes, and MYCN status now is being used world wide as a standard marker for neuroblastoma stratification...
  4. Pasmant E, Laurendeau I, Heron D, Vidaud M, Vidaud D, Bieche I. Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF. Cancer Res. 2007;67:3963-9 pubmed
  5. Yeh I, Lenci R, Qin Y, Buddavarapu K, Ligon A, Leteurtre E, et al. A germline mutation of the KIF1B beta gene on 1p36 in a family with neural and nonneural tumors. Hum Genet. 2008;124:279-85 pubmed publisher
    ..This may imply the existence of a tissue-specific gene dosage requirement for its tumorigenesis...
  6. Hemminki K, Tretli S, Sundquist J, Johannesen T, Granström C. Familial risks in nervous-system tumours: a histology-specific analysis from Sweden and Norway. Lancet Oncol. 2009;10:481-8 pubmed publisher
    ..There are limited data available on tumour subtype-specific familial risks for nervous-system tumours. We aimed to provide such data at the population level...
  7. Cher L. Cancer and the nervous system. Med J Aust. 2001;175:277-82 pubmed
    ..Surgery, radiotherapy and chemotherapy can improve survival for patients. Anticancer therapies can have neurotoxic side effects...
  8. Talbäck M, Stenbeck M, Rosén M, Barlow L, Glimelius B. Cancer survival in Sweden 1960-1998--developments across four decades. Acta Oncol. 2003;42:637-59 pubmed
    ..Survival for breast and cervical cancer also improved during the 1990s, but not that for pancreatic, liver or lung cancer...
  9. Marian C, Scope A, Laud K, Friedman E, Pavlotsky F, Yakobson E, et al. Search for germline alterations in CDKN2A/ARF and CDK4 of 42 Jewish melanoma families with or without neural system tumours. Br J Cancer. 2005;92:2278-85 pubmed
    ..We conclude that in the majority of Ashkenazi Jewish families, the genes tested are unlikely to be implicated in the predisposition to melanoma and associated neural system tumours...

More Information

Publications109 found, 100 shown here

  1. Altieri A, Castro F, Bermejo J, Hemminki K. Association between number of siblings and nervous system tumors suggests an infectious etiology. Neurology. 2006;67:1979-83 pubmed
    ..To estimate the effect of the number of siblings on the risk of histopathologic subtypes of tumors of the nervous system using large population-based data...
  2. McClatchey A. Neurofibromatosis. Annu Rev Pathol. 2007;2:191-216 pubmed
    ..An important outcome of the study of neurofibromatosis-associated tumorigenesis has been insight into the more general molecular and cellular bases of nervous system tumors...
  3. Hemminki K, Tretli S, Olsen J, Tryggvadottir L, Pukkala E, Sundquist J, et al. Familial risks in nervous system tumours: joint Nordic study. Br J Cancer. 2010;102:1786-90 pubmed publisher
    ..Familial nervous system cancers are rare and limited data on familial aspects are available particularly on site-specific tumours...
  4. Burchiel K, Johans T, Ochoa J. The surgical treatment of painful traumatic neuromas. J Neurosurg. 1993;78:714-9 pubmed
  5. Huson S, Harper P, Compston D. Von Recklinghausen neurofibromatosis. A clinical and population study in south-east Wales. Brain. 1988;111 ( Pt 6):1355-81 pubmed
    ..The combined frequency for each category based on this survey was 12%, 16% and 4.4-5.2%, respectively. ..
  6. Hemmi A, Inaniwa Y, Ohno S, Fujii Y, Terada N, Mitsumata M, et al. Relationship between skeinoid fibers and stromal matrix in gastrointestinal stromal tumors: morphometric analysis with quick-freezing and deep-etching method. Pathol Int. 2001;51:338-48 pubmed
    ..14). Although we need further studies with additional GIST cases, we speculate that the pericellular matrix of GIST with SMD is not suitable for SF development. ..
  7. Scintu F, Capra F, Giordano M, Frau G, Mascia R, Comella D, et al. [Neuromuscular and vascular hamartoma of the small intestine. Report of a clinical case and review of the literature]. Chir Ital. 2001;53:393-8 pubmed
  8. Coleman C, Rocetes J, Park D, Wallick C, Warn Cramer B, Michel K, et al. Syringolin A, a new plant elicitor from the phytopathogenic bacterium Pseudomonas syringae pv. syringae, inhibits the proliferation of neuroblastoma and ovarian cancer cells and induces apoptosis. Cell Prolif. 2006;39:599-609 pubmed
    ..Syringolin A and structurally modified syringolin A derivatives may serve as new lead compounds for the development of novel anticancer drugs. ..
  9. Jorge R, Martins A, Morais I, Ximenes R, Rodrigues F, Soares B, et al. In vitro studies on Bothrops venoms cytotoxic effect on tumor cells. J Exp Ther Oncol. 2011;9:249-53 pubmed
    ..All Bothrops venoms tested showed cytotoxicity against tumor cell lines through inducing of necrosis and apoptosis. ..
  10. Poulon F, Mehidine H, Juchaux M, Varlet P, Devaux B, Pallud J, et al. Optical properties, spectral, and lifetime measurements of central nervous system tumors in humans. Sci Rep. 2017;7:13995 pubmed publisher
    ..This study defines several optical indexes that can act as combinated indicators to discriminate healthy from tumoral tissues. ..
  11. Krisch K, Buxbaum P, Horvat G, Krisch I, Neuhold N, Ulrich W, et al. Monoclonal antibody HISL-19 as an immunocytochemical probe for neuroendocrine differentiation. Its application in diagnostic pathology. Am J Pathol. 1986;123:100-8 pubmed
  12. Jin Y, Lu H, Liong E, Lau T, Tipoe G. Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors. Histol Histopathol. 2001;16:1013-9 pubmed publisher
    ..Furthermore, the effects of BMP-2, 3, 4 and 5 on peripheral nervous system during neoplastic transformation might be widespread, diverse and antagonistic. ..
  13. Taylor M, Raffel C, Bayani J, Marrano P, Mainprize T, Squire J. Advanced cancer genetics in neurosurgical research. Neurosurgery. 2003;53:1168-78; discussion 1178 pubmed
    ..High demand from an increasingly educated patient population means that neurosurgeons will need to be familiar with many of these techniques. ..
  14. Przkora R, Perez Canto A, Ertel W, Heyde C. Ganglioneuroma : primary tumor or maturation of a suspected neuroblastoma?. Eur Spine J. 2006;15:363-5 pubmed
    ..The association of ganglioneuroma and neuroblastoma and the abnormal urine tests pointing toward a neuroblastoma 11 years ago remains unclear and the possible answers are discussed in our report. ..
  15. Bulun A, Sarici S, Soyer O, Teksam O, Yurdakok M, Caglar M. The triad of nesidioblastosis, congenital neuroblastoma and glomerulocystic disease of the newborn: a case report. Turk J Pediatr. 2005;47:298-302 pubmed
    ..However, whether the presence of glomerulocystic disease in association with those other neurocristopathic pathologies is a coincidental finding or shares a common pathophysiological mechanism remains to be determined. ..
  16. Greene L, Lee H, Angelastro J. The transcription factor ATF5: role in neurodevelopment and neural tumors. J Neurochem. 2009;108:11-22 pubmed publisher
    ..Further studies are needed to identify the transcriptional targets of ATF5 and the mechanisms by which its expression is regulated in neuroprogenitors and tumors. ..
  17. Sordillo P, Helson L, Hajdu S, Magill G, Kosloff C, Golbey R, et al. Malignant schwannoma--clinical characteristics, survival, and response to therapy. Cancer. 1981;47:2503-9 pubmed
    ..Malignant schwannoma should be considered in the differential diagnosis of tumors developing in areas previously treated with radiation. ..
  18. Tanaka A, Kamiakito T, Hakamata Y, Fujii A, Kuriki K, Fukayama M. Extensive neuronal localization and neurotrophic function of fibroblast growth factor 8 in the nervous system. Brain Res. 2001;912:105-15 pubmed
    ..Taken together, the present findings strongly suggest that FGF8 acts as a more generalized neurotrophic factor than previously reported. ..
  19. Weil M. Conformal radiotherapy for brain tumors. Hematol Oncol Clin North Am. 2001;15:1007-15 pubmed
    ..Further studies evaluating the use of three-dimensional conformal radiotherapy in patients with nervous system neoplasms should focus on determining the effects on quality of life for the patient and survival compared with ..
  20. Williams S, Zimmerman R, Bibbo M. BCA-225 immunostain: is it of value in liver fine needle aspiration?. Anal Quant Cytol Histol. 2002;24:245-8 pubmed
    ..No colon metastases were considered positive. BCA-225 may help exclude the diagnoses of metastatic colon adenocarcinoma, neuroendocrine carcinoma and well- to moderately differentiated HCC in this cytologic setting. ..
  21. Adjenou V, Chapiron C, Asquier E, Vinikoff C, Lemarie E, Brunereau L. [Imaging neurological complications from bronchogenic carcinoma]. J Radiol. 2004;85:599-609 pubmed
    ..The goals of this paper are to describe the clinical signs and to illustrate the imaging features of neurological complications related to bronchogenic carcinoma at conventional radiography, CT and MRI. ..
  22. Lallemand D, Saint Amaux A, Giovannini M. Tumor-suppression functions of merlin are independent of its role as an organizer of the actin cytoskeleton in Schwann cells. J Cell Sci. 2009;122:4141-9 pubmed publisher
    ..Thus, tumor suppression by merlin is independent of its role as an organizer of the actin cytoskeleton in Schwann cells. ..
  23. Scheinberg D, Villa C, Escorcia F, McDevitt M. Conscripts of the infinite armada: systemic cancer therapy using nanomaterials. Nat Rev Clin Oncol. 2010;7:266-76 pubmed publisher
  24. Niazi T, Shah L, Chin S, Schmidt M. Isolated intradural lumbosacral tailgut cyst with carcinoid features. J Neurosurg Spine. 2011;14:382-7 pubmed publisher
    ..No peritoneal extension of her disease was found. The authors hypothesize that this is a rare developmental aberration that has not been commonly recognized and potentially has implications for embryological development. ..
  25. Bekele A, Ali A, Gulilat D, Kassa S, Nega B. Patterns of mediastinal tumors operated at the Tikur Anbessa Hospital, Addis Ababa, Ethiopia over a six years period. Ethiop Med J. 2013;51:143-52 pubmed
    ..We would also like to recommend further large scale prospective studies which also included long-term outcome so that we can further understand the situation in the country. ..
  26. McPherson S, Meals R. Digital pacinian corpuscle neuroma eroding bone: a case report. J Hand Surg Am. 1992;17:476-8 pubmed
    ..A case of digital pacinian corpuscle neuroma leading to erosive changes in the adjacent proximal phalanx is reported. Characteristics and previous reports of this relatively uncommon hand tumor are discussed. ..
  27. Wiedenmann B, Kuhn C, Schwechheimer K, Waldherr R, Raue F, Brandeis W, et al. Synaptophysin identified in metastases of neuroendocrine tumors by immunocytochemistry and immunoblotting. Am J Clin Pathol. 1987;88:560-9 pubmed
    ..The possible implications of these findings for tumor diagnosis are discussed. ..
  28. Fraguela Mariña J, Ares Farpón F, Fernández Blanco C, Rosales Juega D, López García S, Gómez Freijoso C. [Intestinal invagination in adult patients due to jejunal tumor with neural differentiation of autonome system (GAN)]. An Med Interna. 2003;20:621-3 pubmed
    ..We report two clinical cases of intestinal invagination due to jejunal GAN tumors that were operated on because of an intestinal obstruction. Diagnostic methods, differential diagnosis and therapeutic approach were analysed. ..
  29. Jurewicz J, Hanke W, Johansson C, Lundqvist C, Ceccatelli S, van den Hazel P, et al. Adverse health effects of children's exposure to pesticides: what do we really know and what can be done about it. Acta Paediatr Suppl. 2006;95:71-80 pubmed
    ..They have been presented and discussed in this paper. Several suggestions of PINCHE concerning action needed regarding pesticides were presented in the paper. ..
  30. Yohay K. Neurofibromatosis type 1 and associated malignancies. Curr Neurol Neurosci Rep. 2009;9:247-53 pubmed
    ..The natural history of NF1-associated malignancies is often different than that of their sporadic counterparts and, as such, management strategies need to be adjusted accordingly. ..
  31. Petri B, van Eijck C, de Herder W, Wagner A, de Krijger R. Phaeochromocytomas and sympathetic paragangliomas. Br J Surg. 2009;96:1381-92 pubmed publisher
    ..The preferred treatment of PCC and PGL is surgical resection; to avoid the lifelong consequences of bilateral adrenalectomy, cortex-sparing adrenalectomy is the treatment of choice. ..
  32. Matsuda Y, Kawamoto Y, Teduka K, Peng W, Yamamoto T, Ishiwata T, et al. Morphological and cytoskeletal alterations of nervous system tumor cells with different culturing methods. Int J Oncol. 2011;38:1253-8 pubmed publisher
    ..In conclusion, this study demonstrated that nervous system tumor cells showed different alterations in morphology, and different cytoskeletal protein expression patterns, depending on the culture methods. ..
  33. Gadahadh R, Rachapalli V, Roberts D. CT appearance of intercostal nerve neurotisation. Br J Radiol. 2012;85:e56-8 pubmed publisher
    ..We present the imaging finding in a 65-year-old female who had an intercostal nerve transfer for a damaged phrenic nerve following a resection for a non-small cell lung carcinoma. ..
  34. Corona Vázquez T, Campillo Serrano C, Lopez M, Mateos G J, Soto Hernandez J. [The neurologic diseases]. Gac Med Mex. 2002;138:533-46 pubmed
    ..Such a system would provide accurate data regarding the magnitude of problems related with such disease and help design adequate care and prevention programs. ..
  35. Korosec B, Glavac D, Volavsek M, Ravnik Glavac M. ATP2A3 gene is involved in cancer susceptibility. Cancer Genet Cytogenet. 2009;188:88-94 pubmed publisher
  36. Gregorian C, Nakashima J, Le Belle J, Ohab J, Kim R, Liu A, et al. Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis. J Neurosci. 2009;29:1874-86 pubmed publisher
  37. Schindler G, Capper D, Meyer J, Janzarik W, Omran H, Herold Mende C, et al. Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. Acta Neuropathol. 2011;121:397-405 pubmed publisher
    ..Future clinical trials should address whether BRAF (V600E) mutant brain tumor patients will benefit from BRAF (V600E)-directed targeted therapies...
  38. BRAM R, Seidman R, Chesler D. Atypical Presentation of a Pediatric Cerebellar Ganglioglioma. Pediatr Neurosurg. 2018;53:43-48 pubmed publisher
    ..Infratentorial GGs typically present with signs and symptoms of increased intracranial pressure (ICP), cranial nerve deficits, or focal cerebellar findings; rarely, these tumors have been associated with focal seizures...
  39. Farkhondeh T, Samarghandian S, Hozeifi S, Azimi Nezhad M. Therapeutic effects of thymoquinone for the treatment of central nervous system tumors: A review. Biomed Pharmacother. 2017;96:1440-1444 pubmed publisher
    ..The present review found that TQ treatment can be considered as a promising therapeutic strategy for human malignant CNS in future. ..
  40. Benoit J, Faisant N, Venier Julienne M, Menei P. Development of microspheres for neurological disorders: from basics to clinical applications. J Control Release. 2000;65:285-96 pubmed
    ..Studies with NGF are reported as an example. A phase I/II clinical trial has been carried out in patients with newly diagnosed glioblastomas to assess the potentialities of 5-FU-loaded microspheres when intracranially implanted. ..
  41. Timeus F, Ricotti E, Crescenzio N, Garelli E, Doria A, Spinelli M, et al. Flt-3 and its ligand are expressed in neural crest-derived tumors and promote survival and proliferation of their cell lines. Lab Invest. 2001;81:1025-37 pubmed
    ..These results provide further evidence that neuroectodermal and hematopoietic cells share common regulatory pathways, and could be of interest in the clinical management of neuroectodermal tumors. ..
  42. Fanburg Smith J, Miettinen M. Low-affinity nerve growth factor receptor (p75) in dermatofibrosarcoma protuberans and other nonneural tumors: a study of 1,150 tumors and fetal and adult normal tissues. Hum Pathol. 2001;32:976-83 pubmed
    ..p75 may be useful to distinguish DFSP from benign fibrous histiocytoma. ..
  43. Wesseling C, Pukkala E, Neuvonen K, Kauppinen T, Boffetta P, Partanen T. Cancer of the brain and nervous system and occupational exposures in Finnish women. J Occup Environ Med. 2002;44:663-8 pubmed
    ..Ecological design and cross-sectional job assessment introduced exposure misclassification and tended to drive risk estimates toward unity. ..
  44. Fleming L, Gomez Marin O, Zheng D, Ma F, Lee D. National Health Interview Survey mortality among US farmers and pesticide applicators. Am J Ind Med. 2003;43:227-33 pubmed
    ..NHIS mortality follow-up represents an important occupational health surveillance instrument. ..
  45. Sokratous G, Polyzoidis S, Ashkan K. Immune infiltration of tumor microenvironment following immunotherapy for glioblastoma multiforme. Hum Vaccin Immunother. 2017;13:2575-2582 pubmed publisher
    ..It still remains unclear which factors influence the above reaction and therefore prediction of response to treatment is still not possible...
  46. Mehrvar N, Mehrvar A, Akbari M, Qaddoumi I. Comprehensive analysis of Iranian reports of pediatric central nervous system tumors. Childs Nerv Syst. 2017;33:1481-1490 pubmed publisher
    ..Our results may guide future efforts in Iran to improve the care for children with CNS tumors and may provide a valuable template for other comprehensive country- and disease-specific retrospective analyses. ..
  47. Fukui M, Yamabe N, Kang K, Zhu B. Growth-stimulatory effect of resveratrol in human cancer cells. Mol Carcinog. 2010;49:750-9 pubmed publisher
    ..This cell type-specific mitogenic effect of resveratrol may also partly contribute to the procarcinogenic effect of alcohol consumption (rich in resveratrol) in the development of certain human cancers. ..
  48. Shaw T, Harkin K, Nietfeld J, Gardner J. Aortic body tumor in full-sibling English bulldogs. J Am Anim Hosp Assoc. 2010;46:366-70 pubmed
    ..This is the first case report of aortic body tumors in sibling dogs, although the condition may not be an uncommon phenomenon. ..
  49. Pisapia D. The Updated World Health Organization Glioma Classification: Cellular and Molecular Origins of Adult Infiltrating Gliomas. Arch Pathol Lab Med. 2017;141:1633-1645 pubmed publisher
    ..Advances in animal models of glioma and a wealth of sophisticated molecular analyses of human glioma tissue have led to a greater understanding of some of the biologic underpinnings of gliomagenesis...
  50. Morrow G, Kim H, Le Pecheur M, Kaul S, Wadhwa R, Tanguay R. Protection from aging by small chaperones: A trade-off with cancer?. Ann N Y Acad Sci. 2010;1197:67-75 pubmed publisher
    ..However, its expression also increased the malignant properties of human transformed cells. The delicate balance between beneficial and noxious effects of this small chaperone are discussed...
  51. Wassberg C, Thorn M, Yuen J, Ringborg U, Hakulinen T. Second primary cancers in patients with cutaneous malignant melanoma: a population-based study in Sweden. Br J Cancer. 1996;73:255-9 pubmed
    ..03-1.88), but no significant associations existed for cancers of the breast, ovary, testis or other endocrine glands. Among tumours of the digestive tract, only colon cancer in men had a significantly increased SIR (1.33, CI = 1.00-1.74)...
  52. Alexandrov V, Anisimov V, Belous N, Vasilyeva I, Mazon V. The inhibition of the transplacental blastomogenic effect of nitrosomethylurea by postnatal administration of buformin to rats. Carcinogenesis. 1980;1:975-8 pubmed
    ..Postnatal administration of the antidiabetic drug buformin decreased the malignant neurogenic tumor incidence 3.5 times (to rats transplacentally treated with NMU)...
  53. Scope A, Friedman E, Azizi E. A familial syndromic association between cutaneous malignant melanoma and neural system tumours. Br J Dermatol. 2004;151:1278-9; author reply 1279 pubmed
  54. Leveque M, Dimitriu C, Gustin T, Jamart J, Gilliard C, Bojanowski M. [Evaluation of neuro-oncology information for French speaking patients on the Internet]. Neurochirurgie. 2007;53:343-55 pubmed
    ..Little is known about the type and the quality of the medical information available on French-speaking websites, especially in the field of neuro-oncology. The purpose of this study was to evaluate the quality of these sites...
  55. Shin D, Ahn E, Kim H, Park S, Kim Y, Yun Y. Non-cancer mortality among long-term survivors of adult cancer in Korea: national cancer registry study. Cancer Causes Control. 2010;21:919-29 pubmed publisher
    ..To investigate the pattern of non-cancer deaths and to determine whether there is excess mortality from non-cancer causes among Korean long-term survivors of adult cancer...
  56. Wang S, Balasundaram G. Potential cancer gene therapy by baculoviral transduction. Curr Gene Ther. 2010;10:214-25 pubmed
    ..The present review outlines the advances in this area and highlights the challenges behind translating the findings from research with baculoviral vectors into clinical practice. ..
  57. Possover M, Kostov P. Laparoscopic management of sacral nerve root schwannoma with intractable vulvococcygodynia: report of three cases and review of literature. J Minim Invasive Gynecol. 2013;20:394-7 pubmed publisher
    ..Compared with classic neurosurgical approaches, laparoscopic exposure of the rectum, ureters, and sacral nerve roots renders the procedure safer and easier, with less risk of postoperative functional morbidity...
  58. Carozza S, Wrensch M, Miike R, Newman B, Olshan A, Savitz D, et al. Occupation and adult gliomas. Am J Epidemiol. 2000;152:838-46 pubmed
  59. Marmor E, Fourney D, Rhines L, Skibber J, Fuller G, Gokaslan Z. Sacrococcygeal ganglioneuroma. J Spinal Disord Tech. 2002;15:265-8 pubmed
    ..This patient also had a previous coccygeal fracture. To the authors' knowledge, there are no other reports of ganglioneuroma in association with a history of trauma...
  60. Trochet D, O Brien L, Gozal D, Trang H, Nordenskjold A, Laudier B, et al. PHOX2B genotype allows for prediction of tumor risk in congenital central hypoventilation syndrome. Am J Hum Genet. 2005;76:421-6 pubmed
    ..These data further highlight the link between congenital malformations and tumor predisposition when a master gene in development is mutated...
  61. Kurtz K, Hoffman H, Zimmerman M, Robinson R. Perineural and vascular invasion in oral cavity squamous carcinoma: increased incidence on re-review of slides and by using immunohistochemical enhancement. Arch Pathol Lab Med. 2005;129:354-9 pubmed
    ..However, the incidence of perineural and vascular invasion varies in the literature, and the use of immunohistochemistry to enhance their detection has not been evaluated in oral cavity squamous cell carcinomas...
  62. Reilly K, Rubin J, Gilbertson R, Garbow J, Roussel M, Gutmann D. Rethinking brain tumors: the fourth Mouse Models of Human Cancers Consortium nervous system tumors workshop. Cancer Res. 2008;68:5508-11 pubmed publisher
  63. Wheeler R. Predictive testing for pre-malignancy as a prelude to adoption? An English case. Fam Cancer. 2010;9:71-4 pubmed publisher
    ..Furthermore, the outcome of the case, a court order to test the child in infancy, can be reviewed in the light of the current law, together with the geneticist's response to this order...
  64. Bambakidis N, Onwuzulike K. Sonic Hedgehog signaling and potential therapeutic indications. Vitam Horm. 2012;88:379-94 pubmed publisher
    ..This chapter provides a summary of the Shh signaling mechanism and a review of its impact in these neurological disorders...
  65. Gari L, Rivers J, Kopf A. Melanomas arising in large congenital nevocytic nevi: a prospective study. Pediatr Dermatol. 1988;5:151-8 pubmed
    ..This was a 2-month-old girl at entry into the study who subsequently developed Touraine's syndrome. She eventually developed a primary melanoma in the central nervous system and died of metastatic disease at the age of 21 months...
  66. Cheung B, Yan J, Smith S, Nguyen T, Lee M, Kavallaris M, et al. Growth inhibitory retinoid effects after recruitment of retinoid X receptor beta to the retinoic acid receptor beta promoter. Int J Cancer. 2003;105:856-67 pubmed
    ..RXRalpha may also participate in the retinoid signal, but through mechanisms that do not involve RARbeta...
  67. Baehring J, Hochberg F. Primary lymphoma of the nervous system. Cancer J. 2006;12:1-13 pubmed
    ..Better diagnostic tools are required for earlier diagnosis and monitoring of treatment response. A deeper understanding of the pathogenesis of primary nervous system lymphoma may reveal new therapeutic targets...
  68. Suarez C, Sevilla M, Llorente J. Temporal paragangliomas. Eur Arch Otorhinolaryngol. 2007;264:719-31 pubmed
    ..Surgical control of the tumour can be expected in 70-85% of the patients and is clearly dependent on the tumour stage. Tumour size determines success in hearing and lower cranial nerves preservation...
  69. O DORISIO M, Khanna G, Bushnell D. Combining anatomic and molecularly targeted imaging in the diagnosis and surveillance of embryonal tumors of the nervous and endocrine systems in children. Cancer Metastasis Rev. 2008;27:665-77 pubmed publisher
  70. Capasso M, Diskin S. Genetics and genomics of neuroblastoma. Cancer Treat Res. 2010;155:65-84 pubmed publisher
    ..Looking forward, a major challenge will be to understand how inherited genetic variation and acquired somatic alterations in the tumor genome interact to exact phenotypic differences in neuroblastoma, and cancer in general...
  71. Katyal S, Glubrecht D, Li L, Gao Z, Godbout R. Disabled-1 alternative splicing in human fetal retina and neural tumors. PLoS ONE. 2011;6:e28579 pubmed publisher
    ..Dab1-E- and Dab-L-like isoforms are also expressed in childhood neural tumors, with preferential enrichment of Dab1-L-like and Dab1-E-like isoforms in retinoblastoma and neuroblastoma, respectively...
  72. Peek S, del Piero F, Rebhun W, Adamus C. Multicentric schwannomas causing chronic ruminal tympany and forelimb paresis in a Holstein cow. Vet Rec. 1997;140:504-5 pubmed
    ..A postmortem examination demonstrated numerous schwannomas affecting peripheral nerves and several thoracic and abdominal viscera...
  73. Krinke G, Kaufmann W, Mahrous A, Schaetti P. Morphologic characterization of spontaneous nervous system tumors in mice and rats. Toxicol Pathol. 2000;28:178-92 pubmed
  74. Scanga D, Martin W, Delbeke D. Value of FDG PET imaging in the management of patients with thyroid, neuroendocrine, and neural crest tumors. Clin Nucl Med. 2004;29:86-90 pubmed
    ..The purpose of this study was to evaluate the value and impact on management of FDG PET imaging in patients with biopsy-proved neuroendocrine and neural crest tumors, as well as thyroid carcinoma of various types...
  75. Marengo B, De Ciucis C, Ricciarelli R, Furfaro A, Colla R, Canepa E, et al. p38MAPK inhibition: a new combined approach to reduce neuroblastoma resistance under etoposide treatment. Cell Death Dis. 2013;4:e589 pubmed publisher
    ..Collectively, our results suggest that p38MAPK inhibition, in combination with standard chemotherapy, could represent an effective strategy to counteract NB resistance in stage-IV patients...
  76. Rogawski D, Vitanza N, Gauthier A, Ramaswamy V, Koschmann C. Integrating RNA sequencing into neuro-oncology practice. Transl Res. 2017;189:93-104 pubmed publisher
    ..As RNA-seq is a relatively new technique, many further applications yielding new advances in CNS tumor research and management are expected in the coming years. ..
  77. Gliatto J, Crawford M, Snider T, Pechman R. Multiple organ metastasis of an aortic body tumor in a boxer. J Am Vet Med Assoc. 1987;191:1110-2 pubmed
    ..Macroscopic and/or microscopic evidence of metastasis of the tumor was seen in the lungs, myocardium, spleen, liver, kidneys, and dura mater over the cerebellum...
  78. McKie E, Maclean A, Lewis A, Cruickshank G, Rampling R, Barnett S, et al. Selective in vitro replication of herpes simplex virus type 1 (HSV-1) ICP34.5 null mutants in primary human CNS tumours--evaluation of a potentially effective clinical therapy. Br J Cancer. 1996;74:745-52 pubmed
    ..It is our opinion that HSV which fails to express ICP34.5 could provide an effective tumour therapy...
  79. Giessling U, Puffer E, Ludwig K. [Gastrointestinal autonomic nerve tumor (GANT)--a rate tumor of the ileum]. Chirurg. 2001;72:600-2 pubmed
    ..GAN tumors are fatal and must be considered malignant. They need radical surgical resection...
  80. Carbone A, Gloghini A, Capello D, Gaidano G. Genetic pathways and histogenetic models of AIDS-related lymphomas. Eur J Cancer. 2001;37:1270-5 pubmed
  81. Amarti A, Ottmani S, Maher M, Bernoussi Z, Khamlichi A, Saidi A. Central nervous system tumors in Morocco. Retrospective analysis of 2374 cases. J Neurosurg Sci. 2001;45:163-70 pubmed
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