malignant histiocytic disorders

Summary

Summary: Distinctive neoplastic disorders of histiocytes. Included are malignant neoplasms of MACROPHAGES and DENDRITIC CELLS.

Top Publications

  1. Vos J, Abbondanzo S, Barekman C, Andriko J, Miettinen M, Aguilera N. Histiocytic sarcoma: a study of five cases including the histiocyte marker CD163. Mod Pathol. 2005;18:693-704 pubmed
    ..CD163 appears to be a specific histiocytic marker and is important in establishing the diagnosis of HS...
  2. Cao M, Eshoa C, Schultz C, Black J, Zu Y, Chang C. Primary central nervous system histiocytic sarcoma with relapse to mediastinum: a case report and review of the literature. Arch Pathol Lab Med. 2007;131:301-5 pubmed
    ..A thorough discussion of the differential diagnosis of histiocytic sarcoma and a review of primary central nervous system histiocytic sarcoma are also presented...
  3. Malone M. The histiocytoses of childhood. Histopathology. 1991;19:105-19 pubmed
    ..On the basis of a comprehensive clinical history and critical interpretation of morphology and immunocytochemistry using an appropriately selected panel of antibodies, a diagnosis can be reached in the majority of cases...
  4. Chain M, Dei Cas I, Carbia S, Xifra M, Wright D, Glorio R, et al. Cutaneous true histiocytic malignancy: true histiocytic lymphoma. J Am Acad Dermatol. 2004;50:S9-10 pubmed
    ..Occasionally, skin lesions are the presenting clinical features. A patient with initially cutaneous THL is described. This and other reported cases confirm that THM are a nosologic entity by themselves...
  5. Zhang S, Zhou X, Wang P, Zhang Y, Huang S. [Primary cutaneous histiocytic sarcoma]. Zhonghua Bing Li Xue Za Zhi. 2006;35:56-7 pubmed
  6. Fidor A, Belniak Legieć E, Kowal M, Legiec W. [Polyradicular neural syndrome in a patient with leukemic variant of malignant histiocytosis]. Neurol Neurochir Pol. 1997;31:1239-44 pubmed
    ..The leukaemia variant as well as nervous system involvement are extremely rare in malignant histiocytosis...
  7. Czogała M, Czogała W, Balwierz W. [Hemophagocytic syndrome: diagnostic problems]. Przegl Lek. 2006;63:47-52 pubmed
    ..Popularisation of the knowledge about the syndrome, diagnostic guidelines and treatment protocols can contribute to more frequent appropriate recognition of HS and to improvement of the treatment results...
  8. Backé E, Schwarting R, Gerdes J, Ernst M, Stein H. Ber-MAC3: new monoclonal antibody that defines human monocyte/macrophage differentiation antigen. J Clin Pathol. 1991;44:936-45 pubmed
  9. Pavlovskaia A, Savelov N, Kovrigina A, Anurova O. [Histiocytic sarcoma from phagocyting histiocytes]. Arkh Patol. 2004;66:44-7 pubmed
    ..Histological and immunohistochemical findings are presented. Differential diagnosis with tumours of hematopoietic and non-hematopoietic nature is described...

More Information

Publications55

  1. Petrovichev N, Chistyakova O, Smirnov A, Poltoranina V, Rudinskaya T. Antimacrophage monoclonal antibody D11 in the diagnosis of tumors of histiocytic origin. Acta Cytol. 1997;41:357-63 pubmed
    ..Nevertheless, MAb D11 may be used for the exclusion of tumors from the MFH group in the case of a negative reaction. The results support the view that MFH is derived from cells of the mononuclear phagocyte system. ..
  2. Schnatter A, Armstrong T, Nicolich M, Thompson F, Katz A, Huebner W, et al. Lymphohaematopoietic malignancies and quantitative estimates of exposure to benzene in Canadian petroleum distribution workers. Occup Environ Med. 1996;53:773-81 pubmed
    ..To evaluate the relation between mortality from lymphohaematopoietic cancer and long term, low level exposures to benzene among male petroleum distribution workers...
  3. Ogasawara H, Mitsumori K, Onodera H, Imazawa T, Shibutani M, Takahashi M, et al. Spontaneous histiocytic sarcoma with possible origin from the bone marrow and lymph node in Donryu and F-344 rats. Toxicol Pathol. 1993;21:63-70 pubmed
  4. Kausalya S, Pardhasaradhi B, Manogaran P, Khar A. Conjugate formation between effector and target as a function of cytotoxicity in antibody-dependent killing of AK-5 tumor. Indian J Exp Biol. 1995;33:161-4 pubmed
  5. Gola A, Wołowiec D, Potoczek S. [Neoplastic diseases of the hematopoietic system and ischemia of the lower limbs]. Pol Tyg Lek. 1991;46:697-9 pubmed
    ..In some cases effective cytostatic treatment diminished the ischemia of the lower limbs. Interactions between various drugs used in the chronic treatment of both pathologies in the same patient was also examined...
  6. Sakai H, Nakano H, Yamaguchi R, Yonemaru K, Yanai T, Masegi T. Establishment of a new canine cell line (CCT) originated from a cutaneous malignant histiocytosis. J Vet Med Sci. 2003;65:731-5 pubmed
    ..These features indicated the cells had a histiocytic nature. Furthermore, by subcutaneous injection to nude mice CCT could successfully form tumors with the morphological and immunohistochemical features similar to the original tumor...
  7. Sørensen A, Lund A, Kunder S, Quintanilla Martinez L, Schmidt J, Wang B, et al. Impairment of alternative splice sites defining a novel gammaretroviral exon within gag modifies the oncogenic properties of Akv murine leukemia virus. Retrovirology. 2007;4:46 pubmed
    ..In the present study we investigate the splice pattern as well as the possible effects of mutating the alternative splice sites on the oncogenic properties of the B-lymphomagenic Akv murine leukemia virus...
  8. Hugel H. [Fibrohistiocytic skin tumors]. J Dtsch Dermatol Ges. 2006;4:544-55 pubmed
    ..dermatofibrosarcoma protuberans; 6. atypical Fibroxanthoma. MALIGNANT: 7. malignant fibrous histiocytoma. All these entities are reviewed in this paper with particular attention devoted to differential diagnostic considerations...
  9. Pavlovskaia A, Bukaeva I, Smirnov A. [Sarcoma consisting of dendritic reticular cells]. Arkh Patol. 1998;60:14-9 pubmed
    ..The recurrent tumor was also surgically removed. Histology of the primary and recurrent tumors was similar. The tumors were studied electron-microscopically and immunohistochemically...
  10. Moretti V, Brooks J, Ogilvie C. Case report: hemosiderotic fibrohistiocytic lipomatous lesion: a clinicopathologic characterization. Clin Orthop Relat Res. 2010;468:2808-13 pubmed publisher
    ..Initially considered the result of a reactive inflammatory process from trauma or vascular disease, newer evidence suggests it may be neoplastic in origin...
  11. Zavodovskaya R, Liao A, Jones C, Yip B, Chien M, Moore P, et al. Evaluation of dysregulation of the receptor tyrosine kinases Kit, Flt3, and Met in histiocytic sarcomas of dogs. Am J Vet Res. 2006;67:633-41 pubmed
  12. Pileri S, Grogan T, Harris N, Banks P, Campo E, Chan J, et al. Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases. Histopathology. 2002;41:1-29 pubmed
    ..This simplified scheme is practical for everyday diagnostic use and should provide a framework for additional investigation of these unusual neoplasms...
  13. Al Brahim N, Salama S. Malignant melanoma with osteoclast-like giant cells: an unusual host response: immunohistochemical and ultrastructural study of three cases and literature review. Am J Dermatopathol. 2005;27:126-9 pubmed
    ..Since only few cases have been reported, greater recognition and documentation may help to evaluate the prognosis of such cases with unusual morphology...
  14. Dorfman D, Hornick J, Shahsafaei A, Freeman G. The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasms. Hum Pathol. 2010;41:1486-94 pubmed publisher
    ..We conclude that histiocytic and dendritic cell neoplasms consistently express TIM-3 and TIM-4 and that these molecules are new markers of neoplasms derived from histiocytic and dendritic cells...
  15. Kammertoens T, Willebrand R, Erdmann B, Li L, Li Y, Engels B, et al. CY15, a malignant histiocytic tumor that is phenotypically similar to immature dendritic cells. Cancer Res. 2005;65:2560-4 pubmed
    ..1 and B7.2 and to secrete tumor necrosis factor alpha and IL-12. Based on these data, CY15 is a dendritic cell-like tumor cell line and may serve as a transplantable tumor model for histiocytosis in humans...
  16. Murărescu E, Lighezan R, Negru D, Chiseliţă I, Plamadeala P, Mihailovici M. Histiocytic sarcoma associated with Hodgkin's disease. Rom J Morphol Embryol. 2005;46:183-7 pubmed
  17. Hirata A, Tsukamoto T, Yamamoto M, Takasu S, Sakai H, Ban H, et al. Early development of histiocytic sarcomas in p53 knockout mice treated with N-bis(2-hydroxypropyl)nitrosamine. Oncol Rep. 2007;18:755-61 pubmed
    ..Our data add to the understanding of the carcinogenic susceptibility of p53 knockout mice, and may help to elucidate the pathogenesis of HS development...
  18. Moore P, Affolter V, Vernau W. Canine hemophagocytic histiocytic sarcoma: a proliferative disorder of CD11d+ macrophages. Vet Pathol. 2006;43:632-45 pubmed
    ..Canine histiocytic proliferative diseases now encompass proliferation of all members of the myeloid histiocytic lineage: Langerhans cells, interstitial DC, and macrophages...
  19. Prud homme A, Rousselot C, de Pinieux G, Voche P, Rosset P. [Hemosiderotic fibrohistiocytic lipomatous lesion: a new entity you must remind]. Ann Chir Plast Esthet. 2007;52:616-20 pubmed
    ..This tumor may have invasive local growth and metastases have not been described so far. We describe the anatomopathologist's key points of their diagnostic. We discuss the main differentials diagnosis and treatment...
  20. Affolter V, Moore P. Feline progressive histiocytosis. Vet Pathol. 2006;43:646-55 pubmed
    ..The etiology of FPH remains unknown. FPH is best considered an initially indolent cutaneous neoplasm, which is mostly slowly progressive and may spread beyond the skin in the terminal stage...
  21. Porter D, Gupte G, Brown R, Spray C, English M, deVille DeGoyet J, et al. Histiocytic sarcoma with interdigitating dendritic cell differentiation. J Pediatr Hematol Oncol. 2004;26:827-30 pubmed
    ..A repeat liver biopsy coupled with splenic biopsy is recommended in young children with unexplained hepatosplenomegaly and thrombocytopenia...
  22. Phelps R, Shoji T. Update on panniculitis. Mt Sinai J Med. 2001;68:262-7 pubmed
    ..Recent developments in etiology, pathogenesis, molecular techniques, and therapy are discussed...
  23. Egeler R, Schmitz L, Sonneveld P, Mannival C, Nesbit M. Malignant histiocytosis: a reassessment of cases formerly classified as histiocytic neoplasms and review of the literature. Med Pediatr Oncol. 1995;25:1-7 pubmed
    ..The current literature on malignant histiocytic disorders is reviewed, and the clinical presentation of patients determined to have histiocytic malignancies ..
  24. Lauritzen A, Delsol G, Hansen N, Horn T, Ersbøll J, Hou Jensen K, et al. Histiocytic sarcomas and monoblastic leukemias. A clinical, histologic, and immunophenotypical study. Am J Clin Pathol. 1994;102:45-54 pubmed
    ..Whether (or how) p53 gene mutations are implicated in their pathogenesis will be an important topic for future investigation...
  25. Stary J, Hrodek O, Housková J. [Histiocytic syndromes in childhood]. Cesk Pediatr. 1990;45:577-81 pubmed
    ..The paper is supplemented by case-histories from the authors' own practice...
  26. Dobson J, Hoather T, McKinley T, Wood J. Mortality in a cohort of flat-coated retrievers in the UK. Vet Comp Oncol. 2009;7:115-21 pubmed publisher
    ..The results confirm that soft tissue sarcoma, particularly histiocytic sarcoma, is a major cause of mortality in this breed...
  27. Heller D, Clifford C, Goldschmidt M, Holt D, Manfredi M, Sorenmo K. Assessment of cyclooxygenase-2 expression in canine hemangiosarcoma, histiocytic sarcoma, and mast cell tumor. Vet Pathol. 2005;42:350-3 pubmed
    ..Although COX-2 has been shown to be overexpressed in selected human sarcomas and hematopoeitic tumors, these results indicate that canine HSA, HS, and MCT do not express COX-2 in any appreciable fashion...
  28. Weiss D. Flow cytometric evaluation of hemophagocytic disorders in canine. Vet Clin Pathol. 2002;31:36-41 pubmed
    ..Cytomorphologic evaluation alone may be inadequate to consistently differentiate between benign and malignant forms of hemophagocytic disorders...
  29. Edelhoff S, Grond Ginsbach C, von Eggeling F, Korholz D, Gobel U, Senger G. Complex chromosomal rearrangements associated with congenital erythrophagocytotic histiocytosis. Clin Genet. 1998;53:298-302 pubmed
    ..The chromosomal rearrangement might have resulted either in a submicroscopic deletion, in loss of heterozygosity of one or more imprinted genes, or in gene position effects as possible explanations for the clinical course of our patient...
  30. Kaito K, Kobayashi M, Katayama T, Otsubo H, Ogasawara Y, Sekita T, et al. Prognostic factors of hemophagocytic syndrome in adults: analysis of 34 cases. Eur J Haematol. 1997;59:247-53 pubmed
    ..Our data suggests that patients with HPS and any of these risk factors should be treated aggressively with sufficient chemotherapy and supportive care...
  31. O Grady J, Shahidullah H, Doherty V, al Nafussi A. Intravascular histiocytosis. Histopathology. 1994;24:265-8 pubmed
    ..We report a case of intravascular lymphomatosis in which the proliferating cells were of histiocytic type; the tumour has recurred following treatment...
  32. Turner M, Gilmour H, McLaren K, Langlands K, Craig J, Parker A. Regressing atypical histiocytosis: report of two cases with progression to high grade T-cell non-Hodgkin's lymphoma. Hematol Pathol. 1993;7:33-47 pubmed
    ..This description accords with current thinking that many of the conditions previously classified as malignant histiocytosis would be better classified as T-cell non-Hodgkin's lymphoma...
  33. Triscott J, Nappi O, Ferrara G, Wick M. "Pseudoneoplastic" leprosy. Leprosy revisited. Am J Dermatopathol. 1995;17:297-302 pubmed
  34. Zhang D, McGuirk J, Ganguly S, Persons D. Histiocytic/dendritic cell sarcoma arising from follicular lymphoma involving the bone: a case report and review of literature. Int J Hematol. 2009;89:529-532 pubmed publisher
    ..It may also occur concurrently with the progression of follicular lymphoma to a diffuse large B cell lymphoma. ..
  35. Moriello K. Clinical snapshot. Cutaneous nodules in a cat. Compend Contin Educ Vet. 2007;29:204, 240 pubmed
  36. Huang S, Chang C, Huang C, Chang C. Histiocytic sarcoma - a case with evenly distributed multinucleated giant cells. Pathol Res Pract. 2007;203:683-9 pubmed
    ..This case posed great difficulty in clinical and pathological diagnoses. Gross pictures, microscopic findings, and extensive immunostains are important for the differential diagnosis...
  37. Onciu M. Histiocytic proliferations in childhood. Am J Clin Pathol. 2004;122 Suppl:S128-36 pubmed
    ..In addition, a brief review of the pathologic features of the lysosomal storage disorders is included, with an emphasis on findings relevant to the practicing hematopathologist, exemplified with cases presented at the workshop...
  38. Khosravi Shahi P, del Castillo Rueda A. [Histiocytic sarcoma]. Med Clin (Barc). 2006;127:78-9 pubmed
  39. Carrasco D, Fenton T, Sukhdeo K, Protopopova M, Enos M, You M, et al. The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans. Cancer Cell. 2006;9:379-90 pubmed
    ..These genetic and translational observations establish a cooperative role of Pten and Ink4a/Arf in the development of HS and provide mechanistic insights into the pathogenesis of human HS...
  40. Khalil Z, Niehans G, Keel S, Kappel T, Ewing S. CD31 in histiocytic malignancies. Am J Surg Pathol. 2002;26:1373-6; author reply 1376 pubmed
  41. Rhodes M, Bucher J, Peckham J, Kissling G, Hejtmancik M, Chhabra R. Carcinogenesis studies of benzophenone in rats and mice. Food Chem Toxicol. 2007;45:843-51 pubmed
  42. Naranjo C, Dubielzig R, Friedrichs K. Canine ocular histiocytic sarcoma. Vet Ophthalmol. 2007;10:179-85 pubmed
    ..To describe and characterize histiocytic sarcoma (HS) first detected in the eyes of dogs using the large database at the comparative ocular pathology laboratory of Wisconsin (COPLOW)...
  43. Webb D. Histiocyte disorders. Br Med Bull. 1996;52:818-25 pubmed
    ..Due to the rarity of histiocyte disorders, collaborative studies are essential to improve understanding and advance treatment...
  44. Lemes A, de la Iglesia S, Santana C, Cigudosa J, Matutes E, Molero T. t(2;5) associated with a histiocytic-monocytic neoplasm. Leuk Lymphoma. 2001;41:429-33 pubmed
    ..This unusual case ilustrates that t(2;5) is not exclusive for ALCL but may be found in a few cases of rare neoplasms derived from the histiocytic-monocytic cells...
  45. Ramalho A, Nunes M, Adad S, Leitão S, Micheletti A. Hemosiderotic fibrohistiocytic lipomatous lesion: case report and review of the literature. Sao Paulo Med J. 2009;127:174-6 pubmed
    ..Lesions of the adipose tissue are the most common type of soft-tissue lesion among adults...
  46. Sheldon W, Bucci T, Hart R, Turturro A. Age-related neoplasia in a lifetime study of ad libitum-fed and food-restricted B6C3F1 mice. Toxicol Pathol. 1995;23:458-76 pubmed
    ..These data add to the existing knowledge base needed for future studies of dietary restriction and aging as well to evaluate nutrition of animals used in bioassays...