follicular lymphoma

Summary

Summary: Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES.

Top Publications

  1. Federico M, Bellei M, Marcheselli L, Luminari S, Lopez Guillermo A, Vitolo U, et al. Follicular lymphoma international prognostic index 2: a new prognostic index for follicular lymphoma developed by the international follicular lymphoma prognostic factor project. J Clin Oncol. 2009;27:4555-62 pubmed publisher
    ..a prospective collection of data would enable the development of a more accurate prognostic index for follicular lymphoma (FL) by using parameters which could not be retrospectively studied before, and by choosing progression-..
  2. Gupta M, Dillon S, Ziesmer S, Feldman A, Witzig T, Ansell S, et al. A proliferation-inducing ligand mediates follicular lymphoma B-cell proliferation and cyclin D1 expression through phosphatidylinositol 3-kinase-regulated mammalian target of rapamycin activation. Blood. 2009;113:5206-16 pubmed publisher
    ..In support of murine studies, we find that APRIL induces proliferation of human patient follicular lymphoma (FL) B cells in a TACI-dependent manner...
  3. Eide M, Liestøl K, Lingjaerde O, Hystad M, Kresse S, Meza Zepeda L, et al. Genomic alterations reveal potential for higher grade transformation in follicular lymphoma and confirm parallel evolution of tumor cell clones. Blood. 2010;116:1489-97 pubmed publisher
    Our aim was to examine the genetics of clonal evolution in follicular lymphoma (FL) and to identify genetic alterations associated with disease progression...
  4. Abulayha A, Tabal S, Shawesh E, Elbasir M, Elbanani A, Lamami Y, et al. Depletion of peripheral blood B cells with Rituximab and phenotype characterization of the recovering population in a patient with follicular lymphoma. Leuk Res. 2010;34:307-11 pubmed publisher
    ..We phenotypically analyzed reconstitution of peripheral B cells in a male patient with follicular lymphoma following their depletion with Rituximab...
  5. Coelho V, Krysov S, Ghaemmaghami A, Emara M, Potter K, Johnson P, et al. Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins. Proc Natl Acad Sci U S A. 2010;107:18587-92 pubmed publisher
    Surface Ig (sIg) of follicular lymphoma (FL) is vital for tumor cell survival. We found previously that the Ig in FL is unusual, because the variable region genes carry sequence motifs for N-glycan addition...
  6. Khouri I, McLaughlin P, Saliba R, Hosing C, Korbling M, Lee M, et al. Eight-year experience with allogeneic stem cell transplantation for relapsed follicular lymphoma after nonmyeloablative conditioning with fludarabine, cyclophosphamide, and rituximab. Blood. 2008;111:5530-6 pubmed publisher
    Nonmyeloablative stem cell transplantation in patients with follicular lymphoma has been designed to exploit the graft-versus-lymphoma immunity. The long-term effectiveness and toxicity of this strategy, however, is unknown...
  7. Cheung K, Delaney A, Ben Neriah S, Schein J, Lee T, Shah S, et al. High resolution analysis of follicular lymphoma genomes reveals somatic recurrent sites of copy-neutral loss of heterozygosity and copy number alterations that target single genes. Genes Chromosomes Cancer. 2010;49:669-81 pubmed publisher
    ..genomic hybridization, and Affymetrix 500K SNP arrays, was applied to the study of the tumor genomes of 25 follicular lymphoma biopsy samples with paired normal DNA samples to characterize balanced translocations, copy number ..
  8. Zhang D, McGuirk J, Ganguly S, Persons D. Histiocytic/dendritic cell sarcoma arising from follicular lymphoma involving the bone: a case report and review of literature. Int J Hematol. 2009;89:529-532 pubmed publisher
    Histiocytic/dendritic cell sarcomas arising from follicular lymphoma are very rare and poorly understood lesions. We describe a case, which is unique in that it presented with a hipbone lesion simultaneously with axillary lymphadenopathy...
  9. Green M, Gandhi M, Courtney M, Marlton P, Griffiths L. Relative abundance of full-length and truncated FOXP1 isoforms is associated with differential NFkappaB activity in Follicular Lymphoma. Leuk Res. 2009;33:1699-702 pubmed publisher
    ..Our results provide strong evidence that relative FOXP1 isoform abundance is associated with NFkappaB activity in FL, and could potentially be used as a marker for this gene signature. ..

More Information

Publications91

  1. Laudenschlager M, Tyler K, Geis M, Koch M, Graham D. A rare case of synchronous invasive ductal carcinoma of the breast and follicular lymphoma. S D Med. 2010;63:123-5 pubmed
    ..breast with micrometastasis to a non-sentinel lymph node and subsequent incidental finding of a low-grade follicular lymphoma in an axillary node of a 52-year-old woman...
  2. Ushmorov A, Leithäuser F, Ritz O, Barth T, Moller P, Wirth T. ABF-1 is frequently silenced by promoter methylation in follicular lymphoma, diffuse large B-cell lymphoma and Burkitt's lymphoma. Leukemia. 2008;22:1942-4 pubmed publisher
  3. Younes S, Beck A, Lossos I, Levy R, Warnke R, Natkunam Y. Immunoarchitectural patterns in follicular lymphoma: efficacy of HGAL and LMO2 in the detection of the interfollicular and diffuse components. Am J Surg Pathol. 2010;34:1266-76 pubmed publisher
    b>Follicular lymphoma (FL) can exhibit variant histologic patterns that can lead to confusion with other B-cell lymphomas and reactive conditions...
  4. D Amore F, Chan E, Iqbal J, Geng H, Young K, Xiao L, et al. Clonal evolution in t(14;18)-positive follicular lymphoma, evidence for multiple common pathways, and frequent parallel clonal evolution. Clin Cancer Res. 2008;14:7180-7 pubmed publisher
    b>Follicular lymphoma typically has acquired a t(14;18) translocation, but subsequent additional cytogenetic abnormalities contribute to disease progression...
  5. Carlotti E, Wrench D, Matthews J, Iqbal S, Davies A, Norton A, et al. Transformation of follicular lymphoma to diffuse large B-cell lymphoma may occur by divergent evolution from a common progenitor cell or by direct evolution from the follicular lymphoma clone. Blood. 2009;113:3553-7 pubmed publisher
    ..On the basis of the father/son model, this CPC must be long-lived, providing a possible explanation for the incurable nature of this disease. ..
  6. Gyan E, Foussard C, Bertrand P, Michenet P, Le Gouill S, Berthou C, et al. High-dose therapy followed by autologous purged stem cell transplantation and doxorubicin-based chemotherapy in patients with advanced follicular lymphoma: a randomized multicenter study by the GOELAMS with final results after a median follow-up of 9. Blood. 2009;113:995-1001 pubmed publisher
    Autologous stem cell transplantation (ASCT) as first-line therapy for follicular lymphoma (FL) remains controversial...
  7. Karube K, Ying G, Tagawa H, Niino D, Aoki R, Kimura Y, et al. BCL6 gene amplification/3q27 gain is associated with unique clinicopathological characteristics among follicular lymphoma without BCL2 gene translocation. Mod Pathol. 2008;21:973-8 pubmed publisher
    Although approximately 10-20% cases of follicular lymphoma lack BCL2 gene rearrangement, there are few reports having described the alternative genetic aberrations and their association about clinicopathological features...
  8. Díaz Alderete A, Doval A, Camacho F, Verde L, Sabin P, Arranz Saez R, et al. Frequency of BCL2 and BCL6 translocations in follicular lymphoma: relation with histological and clinical features. Leuk Lymphoma. 2008;49:95-101 pubmed publisher
    ..Clinical and histological differences between BCL2-/BCL6+ and BCL2+/BCL6+ tumours could reflect an interplay between both translocations. ..
  9. Vajdic C, van Leeuwen M, Turner J, McDonald A, Webster A, McDonald S, et al. No excess risk of follicular lymphoma in kidney transplant and HIV-related immunodeficiency. Int J Cancer. 2010;127:2732-5 pubmed publisher
    ..83, 95% CI: 13.61-22.95) and after HIV infection (SIR 58.81, 95% CI: 52.59-65.56). Rates of follicular lymphoma (FL) were neither significantly increased nor decreased in transplant recipients (SIR 0.82, 95% CI: 0.10-2...
  10. Lopci E, Santi I, Derenzini E, Fonti C, Savelli G, Bertagna F, et al. FDG-PET in the assessment of patients with follicular lymphoma treated by ibritumomab tiuxetan Y 90: multicentric study. Ann Oncol. 2010;21:1877-83 pubmed publisher
    ..of this study is the 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography (PET) evaluation following radioimmunotherapy (RIT) with ibritumomab tiuxetan Y 90 in patients with non-Hodgkin's follicular lymphoma (FL).
  11. Bhagavathi S, Gu K, Loberiza F, Bast M, Vose J, Weisenburger D. Does a diffuse growth pattern predict for survival in patients with low-grade follicular lymphoma?. Leuk Lymphoma. 2009;50:900-3 pubmed publisher
    Low-grade follicular lymphoma (LGFL) is known to have a good prognosis. However, the clinical relevance of the presence and extent of diffuse growth areas within LGFL is not clear...
  12. Howard M, Dufresne S, Swerdlow S, Cook J. Follicular lymphoma of the spleen: multiparameter analysis of 16 cases. Am J Clin Pathol. 2009;131:656-62 pubmed publisher
    b>Follicular lymphoma (FL) involving the spleen must be distinguished from reactive hyperplasia and from other lymphomas. A prior study reported that splenic FLs frequently lack BCL2 expression, further complicating diagnosis...
  13. Gribben J. Implications of the tumor microenvironment on survival and disease response in follicular lymphoma. Curr Opin Oncol. 2010;22:424-30 pubmed publisher
    Although outcomes for patients with follicular lymphoma have improved with chemoimmunotherapy, the disease remains incurable...
  14. Martinez Lopez J, Rivero A, Rapado I, Montalban C, Paz Carreira J, Canales M, et al. Influence of MBL-2 mutations in the infection risk of patients with follicular lymphoma treated with rituximab, fludarabine, and cyclophosphamide. Leuk Lymphoma. 2009;50:1283-9 pubmed publisher
    ..mutations and their association with severe infections and event-free survival in patients diagnosed with follicular lymphoma, treated uniformly, in the clinical trial LNHF-03...
  15. Skibola C, Bracci P, Halperin E, Conde L, Craig D, Agana L, et al. Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma. Nat Genet. 2009;41:873-5 pubmed publisher
    ..We found that rs6457327 on 6p21.33 was associated with susceptibility to follicular lymphoma (FL; N = 189 cases, 592 controls) with validation in another 456 FL cases and 2,785 controls (combined ..
  16. Xie X, Sundram U, Natkunam Y, Kohler S, Hoppe R, Kim Y, et al. Expression of HGAL in primary cutaneous large B-cell lymphomas: evidence for germinal center derivation of primary cutaneous follicular lymphoma. Mod Pathol. 2008;21:653-9 pubmed publisher
    ..Characterizing PCLBCLs with markers of B-cell maturation stage is a useful framework for studying, classifying, and clinically stratifying these lymphomas. ..
  17. Woon S, Ameratunga R, Croxson M, Taylor G, Neas K, Edkins E, et al. Follicular lymphoma in a X-linked lymphoproliferative syndrome carrier female. Scand J Immunol. 2008;68:153-8 pubmed publisher
    ..More significantly, our study highlights the importance of identifying XLP in families with a high incidence of lymphoma. ..
  18. O Riain C, O Shea D, Yang Y, Le Dieu R, Gribben J, Summers K, et al. Array-based DNA methylation profiling in follicular lymphoma. Leukemia. 2009;23:1858-66 pubmed publisher
    Quantitative methylation profiling was performed using the Illumina GoldenGate Assay in untreated follicular lymphoma (FL) (164), paired pre- and post-transformation FL (20), benign haematopoietic (24) samples and purified B and T cells ..
  19. Agrawal R, Wang J. Pediatric follicular lymphoma: a rare clinicopathologic entity. Arch Pathol Lab Med. 2009;133:142-6 pubmed publisher
    b>Follicular lymphoma, although common in adults, is rare in children. Pediatric follicular lymphoma has a more favorable prognosis than adult follicular lymphoma, even though it is often of higher grade...
  20. Feldman A, Arber D, Pittaluga S, Martinez A, Burke J, Raffeld M, et al. Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone. Blood. 2008;111:5433-9 pubmed publisher
    Rare cases of histiocytic and dendritic cell (H/DC) neoplasms have been reported in patients with follicular lymphoma (FL), but the biologic relationship between the 2 neoplasms is unknown...
  21. Marcus R, Imrie K, Solal Celigny P, Catalano J, Dmoszynska A, Raposo J, et al. Phase III study of R-CVP compared with cyclophosphamide, vincristine, and prednisone alone in patients with previously untreated advanced follicular lymphoma. J Clin Oncol. 2008;26:4579-86 pubmed publisher
    To compare the long-term outcome of patients with previously untreated follicular lymphoma (FL) needing therapy, after treatment with cyclophosphamide, vincristine and prednisone (CVP) versus CVP plus rituximab (R-CVP) and to evaluate ..
  22. Ogura M, Tobinai K, Hatake K, Uchida T, Kasai M, Oyama T, et al. Phase I study of inotuzumab ozogamicin (CMC-544) in Japanese patients with follicular lymphoma pretreated with rituximab-based therapy. Cancer Sci. 2010;101:1840-5 pubmed publisher
    ..3 and 1.8 mg/m(2)). All 13 patients had follicular lymphoma, were previously treated with > or =1 rituximab-alone or rituximab-containing chemotherapy, and were ..
  23. Morschhauser F, Radford J, Van Hoof A, Vitolo U, Soubeyran P, Tilly H, et al. Phase III trial of consolidation therapy with yttrium-90-ibritumomab tiuxetan compared with no additional therapy after first remission in advanced follicular lymphoma. J Clin Oncol. 2008;26:5156-64 pubmed publisher
    We conducted an international, randomized, phase III trial to evaluate the efficacy and safety of consolidation with yttrium-90 ((90)Y)-ibritumomab tiuxetan in patients with advanced-stage follicular lymphoma in first remission.
  24. Pugh T, Ballonoff A, Newman F, Rabinovitch R. Improved survival in patients with early stage low-grade follicular lymphoma treated with radiation: a Surveillance, Epidemiology, and End Results database analysis. Cancer. 2010;116:3843-51 pubmed publisher
    External beam radiation therapy (RT) is the standard treatment for stage I-II, grade 1-2 follicular lymphoma. Because of an indolent natural history, some advocate alternative management strategies, including watchful waiting for this ..
  25. Taskinen M, Jantunen E, Kosma V, Bono P, Karjalainen Lindsberg M, Leppa S. Prognostic impact of CD31-positive microvessel density in follicular lymphoma patients treated with immunochemotherapy. Eur J Cancer. 2010;46:2506-12 pubmed publisher
    ..Furthermore, accumulation of MCs in follicular lymphoma (FL) correlates with unfavourable prognosis after immunochemotherapy...
  26. Czuchlewski D, Csernus B, Bubman D, Hyjek E, Martin P, Chadburn A, et al. Expression of the follicular lymphoma variant translocation 1 gene in diffuse large B-cell lymphoma correlates with subtype and clinical outcome. Am J Clin Pathol. 2008;130:957-62 pubmed publisher
    ..Less well studied is the role of the follicular lymphoma variant translocation 1 (FVT1) gene, which was identified through its involvement in an atypical follicular ..
  27. Cooper L, Sertel O, Kong J, Lozanski G, Huang K, Gurcan M. Feature-based registration of histopathology images with different stains: an application for computerized follicular lymphoma prognosis. Comput Methods Programs Biomed. 2009;96:182-92 pubmed publisher
    b>Follicular lymphoma (FL) is the second most common type of non-Hodgkin's lymphoma. Manual histological grading of FL is subject to remarkable inter- and intra-reader variations...
  28. Sebban C, Brice P, Delarue R, Haioun C, Souleau B, Mounier N, et al. Impact of rituximab and/or high-dose therapy with autotransplant at time of relapse in patients with follicular lymphoma: a GELA study. J Clin Oncol. 2008;26:3614-20 pubmed publisher
    The treatment of patients with follicular lymphoma has changed with the introduction of high-dose therapy (HDT) with autologous stem-cell transplant then with rituximab...
  29. Mollejo M, Rodríguez Pinilla M, Montes Moreno S, Algara P, Dogan A, Cigudosa J, et al. Splenic follicular lymphoma: clinicopathologic characteristics of a series of 32 cases. Am J Surg Pathol. 2009;33:730-8 pubmed publisher
    ..Here we describe a series of follicular lymphoma (FL) cases diagnosed in the spleen, consisting of 32 patients who presented clinically with splenomegaly, ..
  30. Travert M, Ame Thomas P, Pangault C, Morizot A, Micheau O, Semana G, et al. CD40 ligand protects from TRAIL-induced apoptosis in follicular lymphomas through NF-kappaB activation and up-regulation of c-FLIP and Bcl-xL. J Immunol. 2008;181:1001-11 pubmed
    ..These findings suggest that a cotreatment with TRAIL and an inhibitor of NF-kappaB signaling or a blocking anti-CD40 Ab could be of great interest in FL therapy...
  31. Gentles A, Alizadeh A, Lee S, Myklebust J, Shachaf C, Shahbaba B, et al. A pluripotency signature predicts histologic transformation and influences survival in follicular lymphoma patients. Blood. 2009;114:3158-66 pubmed publisher
    Histologic transformation (HT) of follicular lymphoma to diffuse large B-cell lymphoma (DLBCL-t) is associated with accelerated disease course and drastically worse outcome, yet the underlying mechanisms are poorly understood...
  32. Roulland S, Suarez F, Hermine O, Nadel B. Pathophysiological aspects of memory B-cell development. Trends Immunol. 2008;29:25-33 pubmed
    ..these two distinct locations are the normal counterparts of two clinically important pathological entities, follicular lymphoma (FL) and MZ lymphoma (MZL)...
  33. Kahl C, Hirt C, Decker S, Gläser D, Rohde S, Jost K, et al. Multimodal therapy for localized spinal epidural follicular lymphoma. Onkologie. 2010;33:381-4 pubmed publisher
    ..An epidural growth of low-grade lymphoma is even more unusual. Due to this low incidence, therapeutic experience for this entity is limited...
  34. BENNETT L, Schnabel J, Kelchen J, Taylor K, Guo J, Arthur G, et al. DNA hypermethylation accompanied by transcriptional repression in follicular lymphoma. Genes Chromosomes Cancer. 2009;48:828-41 pubmed publisher
    ..microarray technologies were used to study DNA methylation accompanied by transcriptional changes in follicular lymphoma (FL)...
  35. Schwaenen C, Viardot A, Berger H, Barth T, Bentink S, Dohner H, et al. Microarray-based genomic profiling reveals novel genomic aberrations in follicular lymphoma which associate with patient survival and gene expression status. Genes Chromosomes Cancer. 2009;48:39-54 pubmed publisher
    b>Follicular lymphoma (FL) is characterized by a large number of chromosomal aberrations. However, their exact genomic extension and involved target genes remain to be determined...
  36. Tilly H, Zelenetz A. Treatment of follicular lymphoma: current status. Leuk Lymphoma. 2008;49 Suppl 1:7-17 pubmed publisher
    With the recent proliferation of treatment options for patients with follicular lymphoma (FL), median survival has been shown to have improved, from 84 months between 1983 and 1989 to 93 months between 1993 and 1999...
  37. Shiraishi J, Nakagawa Y, Kurata M, Yamamoto K, Abe Y, Toyoda Y, et al. Follicular lymphoma with marked infiltration of eosinophils. Pathol Int. 2008;58:701-5 pubmed publisher
    ..Reported herein is a case of follicular lymphoma with extensive lymph node infiltration by eosinophils...
  38. de Jong D, Koster A, Hagenbeek A, Raemaekers J, Veldhuizen D, Heisterkamp S, et al. Impact of the tumor microenvironment on prognosis in follicular lymphoma is dependent on specific treatment protocols. Haematologica. 2009;94:70-7 pubmed publisher
    The clinical behavior of follicular lymphoma is largely determined by properties of the non-malignant tumor microenvironment...
  39. Canioni D, Salles G, Mounier N, Brousse N, Keuppens M, Morchhauser F, et al. High numbers of tumor-associated macrophages have an adverse prognostic value that can be circumvented by rituximab in patients with follicular lymphoma enrolled onto the GELA-GOELAMS FL-2000 trial. J Clin Oncol. 2008;26:440-6 pubmed
    High amounts of intratumoral macrophages have been shown to correlate with poor prognosis in patients with follicular lymphoma (FL) treated with chemotherapy without rituximab...
  40. Tageja N, Padheye S, Dandawate P, al Katib A, Mohammad R. New targets for the treatment of follicular lymphoma. J Hematol Oncol. 2009;2:50 pubmed publisher
    ..witnessed striking advances in our understanding of the biological factors underlying the development of Follicular lymphoma (FL)...
  41. Wahlin B, Aggarwal M, Montes Moreno S, Gonzalez L, Roncador G, Sanchez Verde L, et al. A unifying microenvironment model in follicular lymphoma: outcome is predicted by programmed death-1--positive, regulatory, cytotoxic, and helper T cells and macrophages. Clin Cancer Res. 2010;16:637-50 pubmed publisher
    The microenvironment influences outcome in follicular lymphoma. Our hypothesis was that several immune cell subsets are important for disease outcome and their individual prognostic importance should be demonstrable in the same analysis ..
  42. Ai W, Hou J, Zeiser R, Czerwinski D, Negrin R, Levy R. Follicular lymphoma B cells induce the conversion of conventional CD4+ T cells to T-regulatory cells. Int J Cancer. 2009;124:239-44 pubmed publisher
    ..Some studies have shown that T-cell receptor (TCR) stimulation can convert conventional T cells into Treg. Follicular lymphoma (FL) B cells can enhance this Treg conversion...
  43. Gu K, Chan W, Hawley R. Practical detection of t(14;18)(IgH/BCL2) in follicular lymphoma. Arch Pathol Lab Med. 2008;132:1355-61 pubmed publisher
    The t(14;18)(q32;q21) translocation is the genetic hallmark of follicular lymphoma. Detection of this translocation can facilitate the diagnosis of follicular lymphoma and can be used to monitor response to therapy and level of residual ..
  44. Campbell B, Voss N, Woods R, Gascoyne R, Morris J, Pickles T, et al. Long-term outcomes for patients with limited stage follicular lymphoma: involved regional radiotherapy versus involved node radiotherapy. Cancer. 2010;116:3797-806 pubmed publisher
    Given the indolent behavior of follicular lymphoma (FL), it is controversial whether limited stage FL can be cured using radiotherapy (RT). Furthermore, the optimal RT field size is unclear...
  45. Stacy R, Jakobiec F, Schoenfield L, Singh A. Unifocal and multifocal reactive lymphoid hyperplasia vs follicular lymphoma of the ocular adnexa. Am J Ophthalmol. 2010;150:412-426.e1 pubmed publisher
    To characterize the differentiating histopathologic and immunophenotypic features of reactive lymphoid hyperplasia (RLH) and follicular lymphoma of the ocular adnexa.
  46. Arcaini L, Montanari F, Alessandrino E, Tucci A, Brusamolino E, Gargantini L, et al. Immunochemotherapy with in vivo purging and autotransplant induces long clinical and molecular remission in advanced relapsed and refractory follicular lymphoma. Ann Oncol. 2008;19:1331-5 pubmed publisher
    To evaluate the clinical outcome of patients with relapsed or refractory follicular lymphoma treated with immunochemotherapy, in vivo purging and high-dose therapy with autotransplant.
  47. Jacobs S, Swerdlow S, Kant J, Foon K, Jankowitz R, Land S, et al. Phase II trial of short-course CHOP-R followed by 90Y-ibritumomab tiuxetan and extended rituximab in previously untreated follicular lymphoma. Clin Cancer Res. 2008;14:7088-94 pubmed publisher
    Radioimmunotherapy has been approved for relapsed follicular lymphoma (FL), including rituximab-refractory FL...
  48. Yamamoto S, Nakase H, Yamashita K, Matsuura M, Takada M, Kawanami C, et al. Gastrointestinal follicular lymphoma: review of the literature. J Gastroenterol. 2010;45:370-88 pubmed publisher
    Gastrointestinal follicular lymphoma (GI-FL) is a relatively rare disease, accounting for only 1%-3.6% of gastrointestinal non-Hodgkin's lymphoma...
  49. Bachy E, Brice P, Delarue R, Brousse N, Haioun C, Le Gouill S, et al. Long-term follow-up of patients with newly diagnosed follicular lymphoma in the prerituximab era: effect of response quality on survival--A study from the groupe d'etude des lymphomes de l'adulte. J Clin Oncol. 2010;28:822-9 pubmed publisher
    PURPOSE First-line treatment for patients with newly diagnosed follicular lymphoma (FL) still remains debated, even in the rituximab-based combination therapy era...
  50. Halldórsdóttir A, Fruhwirth M, Deutsch A, Aigelsreiter A, Beham Schmid C, Agnarsson B, et al. Quantifying the role of aberrant somatic hypermutation in transformation of follicular lymphoma. Leuk Res. 2008;32:1015-21 pubmed publisher
    ..To test the association of SHM with transformation of follicular lymphoma (FL), we sequenced mutational hot spots in five proto-oncogenes (BCL6, PAX5, RHOH, MYC and PIM1) in 32 low-..
  51. Lee I, Huang Y, Chu C, Lee P, Lin H, Lee S. Hepatitis B virus reactivation after 23 months of rituximab-based chemotherapy in an HBsAg-negative, anti-HBs-positive patient with follicular lymphoma. J Chin Med Assoc. 2010;73:156-60 pubmed publisher
    ..antigen (HBsAg) and positive for antibody to hepatitis B surface antigen (anti-HBs) was diagnosed to have follicular lymphoma in 2006. Seventeen cycles of rituximab-based chemotherapy were administered over 23 months...
  52. O Shea D, O Riain C, Gupta M, Waters R, Yang Y, Wrench D, et al. Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation. Blood. 2009;113:2298-301 pubmed publisher
    Acquired homozygosity in the form of segmental acquired uniparental disomy (aUPD) has been described in follicular lymphoma (FL) and is usually due to mitotic recombination...
  53. Higashi M, Sugaya Y, Soeta S, Yokota A, Ishii G, Harigaya K. CD44 expression during tumor progression of follicular lymphoma. Oncol Rep. 2009;22:1135-40 pubmed
    b>Follicular lymphoma often progresses to diffuse type lymphoma...
  54. Lima M, Artico G, Soares F, Martins M, Alves F. Follicular lymphoma in the palate with clinical appearance similar to salivary gland tumors. Quintessence Int. 2010;41:661-3 pubmed
    Intraoral presentation of follicular lymphoma is rare, and only three cases in the palate have been reported to date. The present case report describes an uncommon case of follicular lymphoma affecting the palate...
  55. Kannan S, Neelapu S. Vaccination strategies in follicular lymphoma. Curr Hematol Malig Rep. 2009;4:189-95 pubmed publisher
    b>Follicular lymphoma is one of the most immune-responsive cancers...
  56. Conde L, Halperin E, Akers N, Brown K, Smedby K, Rothman N, et al. Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32. Nat Genet. 2010;42:661-4 pubmed publisher
    ..We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1...
  57. Mattila A, Meri S. Responses to rituximab vary among follicular lymphoma B cells of different maturation stages. Scand J Immunol. 2008;68:159-68 pubmed publisher
    ..In the present study, we determined whether rituximab's effector mechanisms differed between two human follicular lymphoma cell lines that originate from different maturation stages of B cell germinal centre (GC) development...
  58. Calvo K, Dabir B, Kovach A, Devor C, Bandle R, Bond A, et al. IL-4 protein expression and basal activation of Erk in vivo in follicular lymphoma. Blood. 2008;112:3818-26 pubmed publisher
    b>Follicular lymphoma (FL) is characterized by constitutive expression of Bcl-2 as a consequence of t(14;18)...
  59. Gerecitano J, Portlock C, Moskowitz C, Hamlin P, Straus D, Zelenetz A, et al. Phase 2 study of weekly bortezomib in mantle cell and follicular lymphoma. Br J Haematol. 2009;146:652-5 pubmed publisher
    ..This study explored a weekly schedule of bortezomib in follicular lymphoma (FL) and MCL...
  60. Farinha P, Al Tourah A, Gill K, Klasa R, Connors J, Gascoyne R. The architectural pattern of FOXP3-positive T cells in follicular lymphoma is an independent predictor of survival and histologic transformation. Blood. 2010;115:289-95 pubmed publisher
    Previous studies of follicular lymphoma (FL) patients treated heterogeneously have suggested that decreased numbers of regulatory T cells correlates with improved survival...
  61. Solal Céligny P, Cahu X, Cartron G. Follicular lymphoma prognostic factors in the modern era: what is clinically meaningful?. Int J Hematol. 2010;92:246-54 pubmed publisher
    ..The Follicular Lymphoma International Prognostic Index (FLIPI) has been designed to separate patients into 3 groups with ..
  62. Hilchey S, Kobie J, Cochran M, Secor Socha S, Wang J, Hyrien O, et al. Human follicular lymphoma CD39+-infiltrating T cells contribute to adenosine-mediated T cell hyporesponsiveness. J Immunol. 2009;183:6157-66 pubmed publisher
    Our previous work has demonstrated that human follicular lymphoma (FL) infiltrating T cells are anergic, in part due to suppression by regulatory T cells...
  63. Heinzelmann F, Engelhard M, Ottinger H, Bamberg M, Weinmann M. Nodal follicular lymphoma: the role of radiotherapy for stages I and II. Strahlenther Onkol. 2010;186:191-6 pubmed publisher
    To clarify the role of external-beam radiotherapy (RT) in patients with stage I and II nodal follicular lymphoma (FL).
  64. Relander T, Johnson N, Farinha P, Connors J, Sehn L, Gascoyne R. Prognostic factors in follicular lymphoma. J Clin Oncol. 2010;28:2902-13 pubmed publisher
    b>Follicular lymphoma (FL) is one of the most common types of non-Hodgkin's lymphoma. It is usually diagnosed at an advanced stage, for which many treatment options exist, however, no curative standard therapy has been identified...
  65. Bendandi M. Aiming at a curative strategy for follicular lymphoma. CA Cancer J Clin. 2008;58:305-17 pubmed publisher
    b>Follicular lymphoma is often managed as an incurable disease. However, a substantial and growing fraction of patients are achieving long-term disease-free survival from aggressive treatment approaches...
  66. Byers R, Sakhinia E, Joseph P, Glennie C, Hoyland J, Menasce L, et al. Clinical quantitation of immune signature in follicular lymphoma by RT-PCR-based gene expression profiling. Blood. 2008;111:4764-70 pubmed publisher
    ..profiling studies have demonstrated immune response gene signatures that appear predictive of outcome in follicular lymphoma (FL). However, measurement of these marker genes in routine practice remains difficult...
  67. Parker S, Olteanu H, Vantuinen P, Lawton C, Schultz C, Christians K, et al. Follicular lymphoma transformation to dual translocated Burkitt-like lymphoma: improved disease control associated with radiation therapy. Int J Hematol. 2009;90:616-622 pubmed publisher
    ..The optimal treatment for these lymphomas remains undefined. We present two cases of follicular lymphoma with transformation to Burkitt-like lymphoma...
  68. Carreras J, Lopez Guillermo A, Roncador G, Villamor N, Colomo L, Martinez A, et al. High numbers of tumor-infiltrating programmed cell death 1-positive regulatory lymphocytes are associated with improved overall survival in follicular lymphoma. J Clin Oncol. 2009;27:1470-6 pubmed publisher
    Tumor microenvironment influences the behavior of follicular lymphoma (FL), although the specific cell subsets involved are not well known...
  69. Ai W, Tibshirani R, Taidi B, Czerwinski D, Levy R. Anti-idiotype antibody response after vaccination correlates with better overall survival in follicular lymphoma. Blood. 2009;113:5743-6 pubmed publisher
    ..tumor-specific immune response is associated with superior clinical outcome in patients with follicular lymphoma. Here, we investigated whether this positive correlation extends to overall survival (OS)...
  70. Hamadani M, Benson D, Lin T, Porcu P, Blum K, Devine S. High-dose therapy and autologous stem cell transplantation for follicular lymphoma undergoing transformation to diffuse large B-cell lymphoma. Eur J Haematol. 2008;81:425-31 pubmed publisher
    The transformation of follicular lymphoma (FL) to high-grade histology occurs in up to 70% of patients. The role of hematopoietic stem cell transplantation (HSCT) in transformed FL is poorly defined...
  71. Kornacker M, Stumm J, Pott C, Dietrich S, Süssmilch S, Hensel M, et al. Characteristics of relapse after autologous stem-cell transplantation for follicular lymphoma: a long-term follow-up. Ann Oncol. 2009;20:722-8 pubmed publisher
    Pattern and outcome of disease recurrence after autologous stem-cell transplantation (autoSCT) for follicular lymphoma (FL) is not well known.
  72. Arnold A, Aboukameel A, Chen J, Yang D, Wang S, al Katib A, et al. Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model. Mol Cancer. 2008;7:20 pubmed publisher
    ..of anti-apoptotic Bcl-2 family proteins have been linked to a poor survival rate of patients with Follicular Lymphoma (FL)...
  73. de Totero D, Capaia M, Fabbi M, Croce M, Meazza R, Cutrona G, et al. Heterogeneous expression and function of IL-21R and susceptibility to IL-21-mediated apoptosis in follicular lymphoma cells. Exp Hematol. 2010;38:373-83 pubmed publisher
    ..IL-21 may either induce apoptosis or promote growth in different lymphoid malignancies. We therefore investigated the IL-21/IL-21R system in follicular lymphoma (FL) cells.
  74. Friedberg J, Kelly J, Neuberg D, Peterson D, Kutok J, Salloum R, et al. Phase II study of a TLR-9 agonist (1018 ISS) with rituximab in patients with relapsed or refractory follicular lymphoma. Br J Haematol. 2009;146:282-91 pubmed publisher
    ..rituximab (375 mg/m(2) weekly x 4) in patients (n = 23) with relapsed/refractory, histologically confirmed follicular lymphoma, and evaluated immunological changes following the combination...
  75. Morley N, Evans L, Goepel J, Hancock B. Transformed follicular lymphoma: the 25-year experience of a UK provincial lymphoma treatment centre. Oncol Rep. 2008;20:953-6 pubmed
    b>Follicular lymphoma can transform into diffuse large B cell lymphoma, which is usually associated with rapid disease progression, refractoriness to treatment and a poor outcome...
  76. Racila E, Link B, Weng W, Witzig T, Ansell S, Maurer M, et al. A polymorphism in the complement component C1qA correlates with prolonged response following rituximab therapy of follicular lymphoma. Clin Cancer Res. 2008;14:6697-703 pubmed publisher
    ..The purpose of this study was to explore the relationship between the C1qA([276]) polymorphism and the clinical response to rituximab in patients with follicular lymphoma.
  77. Pettengell R, Donatti C, Hoskin P, Poynton C, Kettle P, Hancock B, et al. The impact of follicular lymphoma on health-related quality of life. Ann Oncol. 2008;19:570-6 pubmed
    The purpose of this study was to determine whether there was a relationship between disease activity and health functioning, as measured by a range of patient-reported outcome (PRO) measures in patients with follicular lymphoma (FL).
  78. Masuda A, Nakamura K, Izutsu K, Igarashi K, Ohkawa R, Jona M, et al. Serum autotaxin measurement in haematological malignancies: a promising marker for follicular lymphoma. Br J Haematol. 2008;143:60-70 pubmed publisher
    ..The serum ATX antigen levels in patients with B-cell neoplasms, especially follicular lymphoma (FL), were higher than those in healthy subjects...
  79. Foster M, Gabriel D, Shea T. Role of hematopoietic stem cell transplant in the management of follicular lymphoma. Oncologist. 2009;14:726-38 pubmed publisher
    ..published data regarding the application of autologous and allogeneic stem cell transplant in patients with follicular lymphoma, there remain no uniform indications for its use in this disease...
  80. Ladetto M, De Marco F, Benedetti F, Vitolo U, Patti C, Rambaldi A, et al. Prospective, multicenter randomized GITMO/IIL trial comparing intensive (R-HDS) versus conventional (CHOP-R) chemoimmunotherapy in high-risk follicular lymphoma at diagnosis: the superior disease control of R-HDS does not translate into an overall su. Blood. 2008;111:4004-13 pubmed publisher
    ..R-HDS) to assess the value of intensified chemo-therapy as a first-line treatment for high-risk follicular lymphoma (FL) after the introduction of monoclonal antibodies...
  81. Formica V, Norman A, Cunningham D, Wotherspoon A, Oates J, Chong G. Utility of the Follicular Lymphoma International Prognostic Index and the International Prognostic Index in assessing prognosis and predicting first-line treatment efficacy in follicular lymphoma patients. Acta Haematol. 2009;122:193-9 pubmed publisher
    The Follicular Lymphoma International Prognostic Index (FLIPI) allows physicians to stratify patients into groups with distinct prognoses, however its ability to predict the treatment efficacy has not been fully investigated...
  82. Nowakowski G, Maurer M, Habermann T, Ansell S, Macon W, Ristow K, et al. Statin use and prognosis in patients with diffuse large B-cell lymphoma and follicular lymphoma in the rituximab era. J Clin Oncol. 2010;28:412-7 pubmed publisher
    ..The clinical impact of statin use on the outcome of lymphoma patients treated with a rituximab-containing regimen is unknown...