lymphomatoid granulomatosis

Summary

Summary: An angiocentric and angiodestructive lymphoproliferative disorder primarily involving the lungs. It is caused by an Epstein-Barr virus-induced transformation of the B-cells, in a T-cell rich environment. Clinically and pathologically it resembles EXTRANODAL NK-T-CELL LYMPHOMA.

Top Publications

  1. Mazzie J, Price A, Khullar P, Montoya C, Roberts J, Lee H, et al. Lymphomatoid granulomatosis in a pediatric patient. Clin Imaging. 2004;28:209-13 pubmed
    We report the radiology and pathology of a pediatric patient with lymphomatoid granulomatosis (LG) and review the literature, with an emphasis on the radiological findings and on the small subset of pediatric patients with this rare ..
  2. Koh P, Foyle A, Cartier Y, Langley G, Morrison N, Rocker G, et al. Atypical presentation of lymphomatoid granulomatosis in a patient with longstanding sarcoidosis. Can Respir J. 2004;11:51-4 pubmed
    ..After thoracotomy, this lesion was ultimately found to be lymphomatoid granulomatosis, a rare lymphoproliferative disorder...
  3. Couderc L, Catherinot E. [Sarcoidosis and granulomatous disease: observation]. Rev Mal Respir. 2006;23:5S59-5S67 pubmed
  4. Benamore R, Weisbrod G, Hwang D, Bailey D, Pierre A, Lazar N, et al. Reversed halo sign in lymphomatoid granulomatosis. Br J Radiol. 2007;80:e162-6 pubmed
    b>Lymphomatoid granulomatosis is a rare lymphoproliferative disorder which affects extranodal sites, most commonly lung. Radiologically, it typically presents with multiple nodular opacities that may wax and wane...
  5. Moudir Thomas C, Foulet Roge A, Plat M, Kaswin R, Lepic P, Solal Celigny P, et al. [Efficacy of rituximab in lymphomatoid granulomatosis]. Rev Mal Respir. 2004;21:1157-61 pubmed
    b>Lymphomatoid Granulomatosis is a rare and serious disease, now considered to be a B-cell lymphoma, which is frequently associated with Epstein-Barr virus infection...
  6. Robak T, Kordek R, Urbanska Rys H, Robak P, Bartkowiak J, Bednarek A, et al. High activity of rituximab combined with cladribine and cyclophosphamide in a patient with pulmonary lymphomatoid granulomatosis and bone marrow involvement. Leuk Lymphoma. 2006;47:1667-9 pubmed
  7. Colby T. Current histological diagnosis of lymphomatoid granulomatosis. Mod Pathol. 2012;25 Suppl 1:S39-42 pubmed publisher
    The current histological criteria for the diagnosis of lymphomatoid granulomatosis (LYG) are reviewed and summarized. The majority of patients present with multiple bilateral nodules involving the lung...
  8. Takeishi G, Moroki K, Kawasoe T, Fukushima T, Yokogami K, Nabeshima K, et al. Spontaneous regression and regrowth of central nervous system lymphomatoid granulomatosis: case report. Neurol Med Chir (Tokyo). 2011;51:801-4 pubmed
    A 74-year-old woman presented with central nervous system (CNS) lymphomatoid granulomatosis (LYG) that spontaneously regressed and then regrew shortly thereafter...
  9. Jung K, Sung H, Lee J, Lee K, Shin J, Kim K, et al. A case of pulmonary lymphomatoid granulomatosis successfully treated by combination chemotherapy with rituximab. Chemotherapy. 2009;55:386-90 pubmed publisher
    b>Lymphomatoid granulomatosis (LYG) is a rare angiocentric and angiodestructive lymphoproliferative disease characterized by Epstein-Barr virus-positive B cells admixed with reactive T cells...

More Information

Publications77

  1. Makol A, Kosuri K, Tamkus D, de M Calaca W, Chang H. Lymphomatoid granulomatosis masquerading as interstitial pneumonia in a 66-year-old man: a case report and review of literature. J Hematol Oncol. 2009;2:39 pubmed publisher
    b>Lymphomatoid granulomatosis (LG) is a rare, Epstein-Barr virus (EBV)-associated systemic angiodestructive lymphoproliferative disorder that may progress to a diffuse large B cell lymphoma...
  2. Jordan K, Grothey A, Grothe W, Kegel T, Wolf H, Schmoll H. Successful treatment of mediastinal lymphomatoid granulomatosis with rituximab monotherapy. Eur J Haematol. 2005;74:263-6 pubmed
    b>Lymphomatoid granulomatosis is a rare Epstein-Barr virus (EBV)-positive-B-cell lymphoproliferative disorder. Treatment options include corticosteroids, antiviral therapy, interferon-alpha and chemotherapy...
  3. Polizzotto M, Dawson M, Opat S. Failure of rituximab monotherapy in lymphomatoid granulomatosis. Eur J Haematol. 2005;75:172-3 pubmed
  4. Wu S, Min Y, Ostrzega N, Clements P, Wong A. Lymphomatoid granulomatosis: a rare mimicker of vasculitis. J Rheumatol. 2005;32:2242-5 pubmed
    b>Lymphomatoid granulomatosis (LG) is a rare Epstein-Barr virus-associated lymphoproliferative disorder, with a propensity for blood vessel destruction...
  5. Culhaci N, Levi E, Sen S, Kacar F, Meteoglu I. Pulmonary lymphomatoid granulomatosis evolving to large cell lymphoma in the skin. Pathol Oncol Res. 2002;8:280-2 pubmed
    b>Lymphomatoid granulomatosis is an angiodestructive, angioinvasive lymphoproliferative disorder. It involves most frequently lungs, central nervous system and skin...
  6. Lemieux J, Bernier V, Martel N, Delage R. Autologous hematopoietic stem cell transplantation for refractory lymphomatoid granulomatosis. Hematology. 2002;7:355-8 pubmed
    b>Lymphomatoid granulomatosis (LG) is a rare lymphoproliferative disorder. There is no standard therapy for refractory patient. Here we present the case of a patient with LG of the lung and the brain who was refractory to polychemotherapy...
  7. Oosting Lenstra S, van Marwijk Kooy M. Failure of CHOP with rituximab for lymphomatoid granulomatosis. Neth J Med. 2007;65:442-7 pubmed
    We present a 66-year-old male patient with pulmonary lymphomatoid granulomatosis. The patient had progressive disease after three courses of CHoP and rituximab and, therefore, treatment with interferon-alpha 2b 5 x 10(6) IE three times a ..
  8. Kameda H, Okuyama A, Tamaru J, Itoyama S, Iizuka A, Takeuchi T. Lymphomatoid granulomatosis and diffuse alveolar damage associated with methotrexate therapy in a patient with rheumatoid arthritis. Clin Rheumatol. 2007;26:1585-9 pubmed
    ..diagnosis of Epstein-Barr virus (EBV)-related lymphoproliferative disease (LPD) with the features of lymphomatoid granulomatosis was made...
  9. Shimada K, Matsui T, Kawakami M, Nakayama H, Ozawa Y, Mitomi H, et al. Methotrexate-related lymphomatoid granulomatosis: a case report of spontaneous regression of large tumours in multiple organs after cessation of methotrexate therapy in rheumatoid arthritis. Scand J Rheumatol. 2007;36:64-7 pubmed
    ..The right lung tumour was 8 cm in diameter with a cavity. Biopsy of the lung and liver revealed lymphomatoid granulomatosis (LG) and diffuse large B-cell lymphoma (DLBCL)...
  10. Moertel C, Carlson Green B, Watterson J, Simonton S. Lymphomatoid granulomatosis after childhood acute lymphoblastic leukemia: report of effective therapy. Pediatrics. 2001;107:E82 pubmed
    b>Lymphomatoid granulomatosis, a rare condition in children, affects the lungs primarily but may have significant extrapulmonary manifestations, especially in the central nervous system...
  11. Yazdi A, Metzler G, Weyrauch S, Berneburg M, Bitzer M, Muller Hermelink H, et al. Lymphomatoid granulomatosis induced by imatinib-treatment. Arch Dermatol. 2007;143:1222-3 pubmed
  12. Ishii H, Kishi K, Kushima H, Hashinaga K, Umeki K, Ohama M, et al. [Pulmonary lymphomatoid granulomatosis radiologically mimicking interstitial pneumonia]. Nihon Kokyuki Gakkai Zasshi. 2007;45:483-8 pubmed
    We report a rare case of pulmonary lymphomatoid granulomatosis radiologically mimicking interstitial pneumonia...
  13. Itoh T, Umekawa K, Rensha K, Minami K, Shoji S, Kitaichi M, et al. [A case of grade I lymphomatoid granulomatosis detected as a solitary lung nodule in a health examination]. Nihon Kokyuki Gakkai Zasshi. 2008;46:50-4 pubmed
    ..The pathologic diagnosis of the resected lung was lymphomatoid granulomatosis/angiocentric immunoproliferative lesion (LYG/AIL), grade I. Adjuvant therapy was not performed...
  14. Jaffre S, Jardin F, Dominique S, Duet E, Hubscher P, Genevois A, et al. Fatal haemoptysis in a case of lymphomatoid granulomatosis treated with rituximab. Eur Respir J. 2006;27:644-6 pubmed
    b>Lymphomatoid granulomatosis is a rare angiocentric and angiodestructive disease, which commonly involves the lungs but also the brain, kidneys, liver and skin...
  15. Cameron J, Cackett P. Lymphomatoid granulomatosis associated with bilateral exudative retinal detachments. Arch Ophthalmol. 2007;125:712-3 pubmed
  16. Mukhopadhyay S, Katzenstein A. Biopsy findings in acute pulmonary histoplasmosis: unusual histologic features in 4 cases mimicking lymphomatoid granulomatosis. Am J Surg Pathol. 2010;34:541-6 pubmed publisher
    ..and histiocytes was present in all, and was striking in 3, resulting in a resemblance to grade 1 lymphomatoid granulomatosis (LYG)...
  17. Issakhanian M, Chang L, Cornford M, Witt M, Speck O, Goldberg M, et al. HIV-2 infection with cerebral toxoplasmosis and lymphomatoid granulomatosis. J Neuroimaging. 2001;11:212-6 pubmed
    ..The lesion showed a biochemical and perfusion pattern that was intermediate for infectious and neoplastic processes. Further neuropathology confirmed a secondary diagnosis of lymphomatoid granulomatosis.
  18. Alinari L, Pant S, McNamara K, Kalmar J, Marsh W, Allen C, et al. Lymphomatoid granulomatosis presenting with gingival involvement in an immune competent elderly male. Head Neck Pathol. 2012;6:496-501 pubmed publisher
    b>Lymphomatoid granulomatosis (LYG) represents a B cell lymphoproliferative disorder that appears to be driven by infection of the lesional cells by Epstein-Barr virus (EBV)...
  19. Mizuno T, Takanashi Y, Onodera H, Shigeta M, Tanaka N, Yuya H, et al. A case of lymphomatoid granulomatosis/angiocentric immunoproliferative lesion with long clinical course and diffuse brain involvement. J Neurol Sci. 2003;213:67-76 pubmed
    b>Lymphomatoid granulomatosis (LYG)/angiocentric immunoproliferative lesions (AIL) consist of angiocentric and angiodestructive lymphoreticular proliferation predominantly involving the lungs and other extranodal sites, such as the central ..
  20. Beaty M, Toro J, Sorbara L, Stern J, Pittaluga S, Raffeld M, et al. Cutaneous lymphomatoid granulomatosis: correlation of clinical and biologic features. Am J Surg Pathol. 2001;25:1111-20 pubmed
    b>Lymphomatoid granulomatosis (LYG) is a rare angiocentric and angiodestructive Epstein-Barr virus-associated B-cell lymphoproliferative disorder (EBV-BLPD), varying widely from an indolent process to an aggressive large cell lymphoma...
  21. Zaidi A, Kampalath B, Peltier W, Vesole D. Successful treatment of systemic and central nervous system lymphomatoid granulomatosis with rituximab. Leuk Lymphoma. 2004;45:777-80 pubmed
    b>Lymphomatoid granulomatosis (LYG) is a rare lymphoproliferative disorder with a mortality rate approaching 60% in the first year. The median survival is 14 months from the time of diagnosis...
  22. Joseph R, Chacko B, Manipadam M, Sureka J, Cherian V, John G. Pulmonary lymphomatoid granulomatosis in a renal allograft recipient. Transpl Infect Dis. 2008;10:52-5 pubmed
    b>Lymphomatoid granulomatosis (LYG) is a rare multisystemic angiocentric lymphoproliferative disease, which can masquerade as necrotic tissue. There is a paucity of reports of LYG in renal transplant recipients...
  23. Gaulard P, Henni T, Marolleau J, Haioun C, Henni Z, Voisin M, et al. Lethal midline granuloma (polymorphic reticulosis) and lymphomatoid granulomatosis. Evidence for a monoclonal T-cell lymphoproliferative disorder. Cancer. 1988;62:705-10 pubmed
    b>Lymphomatoid granulomatosis (LG) and polymorphic reticulosis (PR), originally described as distinct entities, now are considered as a single disease process...
  24. Ishiura H, Morikawa M, Hamada M, Watanabe T, Kako S, Chiba S, et al. Lymphomatoid granulomatosis involving central nervous system successfully treated with rituximab alone. Arch Neurol. 2008;65:662-5 pubmed publisher
    To report the successful treatment of a patient with lymphomatoid granulomatosis (LYG), a rare Epstein-Barr virus-positive lymphoproliferative disorder, using rituximab (anti-CD20 monoclonal antibody)...
  25. Cachat F, Meagher Villemure K, Guignard J. Lymphomatoid granulomatosis in a renal transplant patient. Pediatr Nephrol. 2003;18:838-42 pubmed
    b>Lymphomatoid granulomatosis is a rare angiocentric and angiodestructive pulmonary angiitis considered as a variant of the lymphoproliferative disorder group...
  26. Arai H, Oshiro H, Yamanaka S, Yukawa N, Wada N, Rino Y, et al. Grade I lymphomatoid granulomatosis with increased uptake of [18F] fluorodeoxyglucose in positron emission tomography: a case report. J Clin Exp Hematop. 2009;49:39-44 pubmed
    ..describing [18F] fluorodeoxyglucose positron emission tomography (FDG-PET) findings in patients with lymphomatoid granulomatosis (LYG). We report a case of grade I LYG that showed increased uptake of FDG...
  27. Rao R, Vugman G, Leslie W, Loew J, Venugopal P. Lymphomatoid granulomatosis treated with rituximab and chemotherapy. Clin Adv Hematol Oncol. 2003;1:658-60; discussion 660 pubmed
  28. Katzenstein A, Doxtader E, Narendra S. Lymphomatoid granulomatosis: insights gained over 4 decades. Am J Surg Pathol. 2010;34:e35-48 pubmed publisher
    b>Lymphomatoid granulomatosis is a rare lymphoproliferative disease involving predominantly the lung, and there is uncertainty about its relationship to lymphoma...
  29. Sheehy N, Bird B, O Briain D, Daly P, Wilson G. Synchronous regression and progression of pulmonary nodules on chest CT in untreated lymphomatoid granulomatosis. Clin Radiol. 2004;59:451-4 pubmed
  30. Guinee D, Perkins S, Travis W, Holden J, Tripp S, Koss M. Proliferation and cellular phenotype in lymphomatoid granulomatosis: implications of a higher proliferation index in B cells. Am J Surg Pathol. 1998;22:1093-100 pubmed
    Pulmonary involvement by lymphomatoid granulomatosis (LYG) is characterized by nodules of a polymorphous lymphoreticular infiltrate with necrosis, angioinvasion, and variable numbers of large, atypical cells...
  31. Roarke M, Nguyen B. PET/CT characterization and monitoring of disease activity in lymphomatoid granulomatosis. Clin Nucl Med. 2007;32:258-9 pubmed
  32. Hu Y, Liu C, Chiu C, Hsiao L. Successful treatment of elderly advanced lymphomatoid granulomatosis with rituximab-CVP combination therapy. Eur J Haematol. 2007;78:176-7 pubmed
  33. Sebire N, Haselden S, Malone M, Davies E, Ramsay A. Isolated EBV lymphoproliferative disease in a child with Wiskott-Aldrich syndrome manifesting as cutaneous lymphomatoid granulomatosis and responsive to anti-CD20 immunotherapy. J Clin Pathol. 2003;56:555-7 pubmed
    ..A rare angiocentric and angiodestructive form of EBV associated B cell LPD, lymphomatoid granulomatosis (LyG), has also been reported in association with WAS...
  34. Yamauchi Y, Yoshizawa A, Kudo K, Okuwaki H, Niino H, Morita T. [A case of lymphomatoid granulomatosis with multiple thin-walled cavities]. Nihon Kokyuki Gakkai Zasshi. 2002;40:292-8 pubmed
    We report a case of rapidly progressive lymphomatoid granulomatosis. A 48-year-old man was admitted because of hemoptysis and high fever...
  35. Saxena A, Dyker K, Angel S, Moshynska O, Dharampaul S, Cockroft D. Posttransplant diffuse large B-cell lymphoma of "lymphomatoid granulomatosis" type. Virchows Arch. 2002;441:622-8 pubmed
    The exact relationship between lymphomatoid granulomatosis (LyG) and posttransplant lymphoproliferative disorders (PTLDs) is not clear. Both are observed in immunodeficient patients and are Epstein-Barr virus driven...
  36. Braham E, Ayadi Kaddour A, Smati B, Ben Mrad S, Besbes M, El Mezni F. Lymphomatoid granulomatosis mimicking interstitial lung disease. Respirology. 2008;13:1085-7 pubmed publisher
    ..Lymphoid granulomatosis was only diagnosed at post-mortem examination. The range of reported clinical presentations, diagnostic approaches and outcomes are described...
  37. Shanti R, Torres Cabala C, Jaffe E, Wilson W, Brahim J. Lymphomatoid granulomatosis with involvement of the hard palate: a case report. J Oral Maxillofac Surg. 2008;66:2161-3 pubmed publisher
  38. Patsalides A, Atac G, Hedge U, Janik J, Grant N, Jaffe E, et al. Lymphomatoid granulomatosis: abnormalities of the brain at MR imaging. Radiology. 2005;237:265-73 pubmed
    To retrospectively evaluate the magnetic resonance (MR) imaging features of lymphomatoid granulomatosis in the brain.
  39. McCloskey M, Catherwood M, McManus D, Todd G, Cuthbert R, Riley M. A case of lymphomatoid granulomatosis masquerading as a lung abscess. Thorax. 2004;59:818-9 pubmed
    b>Lymphomatoid granulomatosis (LG) is a rare T cell rich, B cell non-Hodgkin's lymphoma which is difficult to diagnose...
  40. Wang X, Huang D, Huang X, Zhang J, Ran Y, Lou X, et al. Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): A lymphocytic reactive response of the central nervous system? A case report. J Neuroimmunol. 2017;305:68-71 pubmed publisher
    ..Here, we report a 51-year-old woman who was diagnosed with CLIPPERS but progressed to primary CNS lymphomatoid granulomatosis, which supports that CLIPPERS is not just an inflammatory CNS disorder.
  41. Kagawa K, Ishida T, Okada H. [Primary central nervous system lymphomatoid granulomatosis: a case report]. No Shinkei Geka. 2011;39:883-9 pubmed
    b>Lymphomatoid granulomatosis (LYG) is a rare Epstein-Barr virus-associated multisystem lymphoproliferative and granulomatous disease histologically characterized by angiocentric and angiodestructive cellular infiltrate...
  42. Kawai N, Miyake K, Nishiyama Y, Yamamoto Y, Sasakawa Y, Haba R, et al. FDG-PET findings of the brain in lymphomatoid granulomatosis. Ann Nucl Med. 2006;20:683-7 pubmed
    ..Diagnosis was made by open biopsy of the right frontal lobe and pathologic specimen was positive for lymphomatoid granulomatosis (LYG)...
  43. Tsuchiyama J, Yoshino T, Mori M, Kondoh E, Oka T, Akagi T, et al. Characterization of a novel human natural killer-cell line (NK-YS) established from natural killer cell lymphoma/leukemia associated with Epstein-Barr virus infection. Blood. 1998;92:1374-83 pubmed
    ..The NK-YS cells preserved the original characteristics of NK cell lymphoma/leukemia and will be a useful tool for the study of biological characteristics of EBV-associated nasal angiocentric NK cell lymphoma/leukemia. ..
  44. Schalper K, Valbuena J. [Primary cerebral lymphomatoid granulomatosis in a HIV-positive patient. Case report]. Rev Med Chil. 2011;139:218-23 pubmed publisher
    ..atypical angiocentric and angiodestructive lymphoid infiltrate containing large pleomorphic CD20 and EBV-positive cells consistent with Lymphomatoid granulomatosis. Other studies were negative. The patient was lost from follow up.
  45. Park H, Hwang D, Kang B, Jung D, Song G, Lee S, et al. Pulmonary lymphomatoid granulomatosis in a dog: evidence of immunophenotypic diversity and relationship to human pulmonary lymphomatoid granulomatosis and pulmonary Hodgkin's disease. Vet Pathol. 2007;44:921-3 pubmed
    We describe a 10-month-old, intact female American Cocker Spaniel with pulmonary lymphomatoid granulomatosis (PLG)...
  46. Carone D, Benedict R, Zivadinov R, Singh B, Ambrus J. Progressive cerebral disease in lymphomatoid granulomatosis causes anterograde amnesia and neuropsychiatric disorder. J Neuroimaging. 2006;16:163-6 pubmed
    ..NP) and serial quantitative magnetic resonance imaging (MRI) findings of a 29-year-old woman with lymphomatoid granulomatosis (LG)...
  47. Guven A, Baskin D. Lymphomatoid granulomatosis in a boy with long-term follow-up. Pediatr Hematol Oncol. 2001;18:377-82 pubmed
    b>Lymphomatoid granulomatosis is an angiocentric lymphoreticular proliferative disease. Some patients go on to develop frank neoplasia...
  48. Hedgire S, Sainani N, McDermott S, Hahn P, Harisinghani M. Mono-belly and beyond: spectrum of imaging manifestations of EBV infection in the abdomen. Clin Imaging. 2013;37:711-7 pubmed publisher
    ..Awareness of the spectrum of imaging findings, high index of suspicion, and appropriate clinical and laboratory information can help in the early and accurate diagnosis in these cases. ..
  49. Horger M, Goeppert B, Hartmann J, Vogel M. [Imaging in lymphomatoid granulomatosis]. Rofo. 2008;180:193-6 pubmed publisher
  50. Hochberg E, Gilman M, Hasserjian R. Case records of the Massachusetts General Hospital. Case 17-2006--a 34-year-old man with cavitary lung lesions. N Engl J Med. 2006;354:2485-93 pubmed
  51. Antic T, Kapur U, Vigneswaran W, Oshima K. Inflammatory sarcomatoid carcinoma: a case report and discussion of a malignant tumor with benign appearance. Arch Pathol Lab Med. 2005;129:1334-7 pubmed
    ..This leads us to concur with the recommendation to exercise caution when attempting the diagnosis of apparently benign lesions on intraoperative frozen section in patients with high clinical suspicion of malignancy. ..
  52. Morice W, Kurtin P, Myers J. Expression of cytolytic lymphocyte-associated antigens in pulmonary lymphomatoid granulomatosis. Am J Clin Pathol. 2002;118:391-8 pubmed
    Paraffin-embedded lung wedge biopsy specimens from 14 patients with pulmonary lymphomatoid granulomatosis (LYG) were analyzed using immunoperoxidase stains specific for T cell- and natural killer cell-associated antigens...
  53. Chen J, Li G, Liu P, Que C, Wang G. [A case report of lymphomatoid granulomatosis and review of the literature]. Beijing Da Xue Xue Bao Yi Xue Ban. 2009;41:484-6 pubmed
    To explore the clinical manifestation of lymphomatoid granulomatosis (LG) and the early diagnosis. Retrospective analyses of the clinical features of LG and pathology features by open lung biopsies were conducted...
  54. Bolaman Z, Kadikoylu G, Polatli M, Barutca S, Culhaci N, Senturk T. Migratory nodules in the lung: lymphomatoid granulomatosis. Leuk Lymphoma. 2003;44:197-200 pubmed
    ..The histopathological diagnosis of the open lung biopsy was lymphomatoid granulomatosis (LG) with a marked angioinvasive lymphocytic perivascular and peribronchial infiltration pattern...
  55. Hatoya S, Kumagai D, Takeda S, Yamamoto E, Nakanishi M, Kuwamura M, et al. Successful management with CHOP for pulmonary lymphomatoid granulomatosis in a dog. J Vet Med Sci. 2011;73:527-30 pubmed
    ..An open lung biopsy was performed and a diagnosis of pulmonary lymphomatoid granulomatosis (LYG) was made...
  56. Rüggeberg A, Deja M, Kaisers U, Steinmuller T, Keske U, Falke T. [Multiorgan failure due to chronic granulomatous disease]. Anaesthesist. 2002;51:731-4 pubmed
    ..This case report describes the typical problems of patients with a congenital immunodeficiency who grow out of the care of highly specialised pediatric-immunological departments...
  57. Le Cam Savin C, Federicci L, Guzman E, Polderman B, Goutorbe F, Dambron P, et al. [Lung mass revealed by multiple subcutaneous nodules]. Ann Pathol. 2004;24:289-90 pubmed
  58. Keen J, Swain J, Rhind S, McGorum B. Lymphoproliferative disease resembling lymphomatoid granulomatosis in a thoroughbred mare. J Vet Intern Med. 2004;18:904-6 pubmed
  59. De Graaff H, Wattjes M, Rozemuller Kwakkel A, Petzold A, Killestein J. Fatal B-cell lymphoma following chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. JAMA Neurol. 2013;70:915-8 pubmed publisher
    ..We report on a well-documented patient who presented with clinical, radiological, and pathological characteristics of CLIPPERS and who had an unfavorable outcome...
  60. McKay K, McNiff J, Subtil A. Prominent CD56 expression by damaged and regenerating muscle fibers in the skin. J Cutan Pathol. 2012;39:425-30 pubmed publisher
    ..Antibodies to CD56 label natural killer cells as well as tissues with neural and neuroendocrine differentiation. Despite its apparently limited distribution, other conditions may unexpectedly show strong CD56 expression...
  61. Tateishi U, Terae S, Ogata A, Sawamura Y, Suzuki Y, Abe S, et al. MR imaging of the brain in lymphomatoid granulomatosis. AJNR Am J Neuroradiol. 2001;22:1283-90 pubmed
    Clinical diagnosis of lymphomatoid granulomatosis (LG) of the brain, in patients without skin or chest lesions, usually is difficult because of the nonspecific neurologic manifestations, laboratory data, and CT appearance...
  62. Shimazaki T, Nagata M, Goto Koshino Y, Tsujimoto H, Shirota K. A case of canine lymphomatoid granulomatosis with cutaneous lesions. J Vet Med Sci. 2010;72:1067-9 pubmed
    ..The presence of clonally expanded T-cells was revealed by the clonal rearrangement of T-cell receptor gamma-chain gene. From the above findings, the dog was diagnosed with lymphomatoid granulomatosis.
  63. Agarwal V, Agarwal A, Pal L, Misra R. Arthritis in lymphomatoid granulomatosis: report of a case and review of literature. Indian J Med Sci. 2004;58:67-71 pubmed
    b>Lymphomatoid granulomatosis (LG) is a rare systemic vasculitis caused by Epstein Barr virus induced transformation of the B-cells in a T-cell rich environment...
  64. Allan R. Anchors away. N Engl J Med. 2007;356:1892-3; author reply 1892-3 pubmed
  65. Kwon E, Katz K, Draft K, Seykora J, Rook A, Wasik M, et al. Posttransplantation lymphoproliferative disease with features of lymphomatoid granulomatosis in a lung transplant patient. J Am Acad Dermatol. 2006;54:657-63 pubmed
    ..features in this case represent posttransplantation lymphoproliferative disease with features of lymphomatoid granulomatosis. The case also highlights the importance of clinical and pathologic examination of cutaneous lesions in ..
  66. Suzuki H, Takeda H, Kishi H, Machida Y, Mikura S, Watanabe K. [Reactivation of Epstein-Barr virus is involved in the pathogenesis of lymphomatoid granulomatosis]. Nihon Kokyuki Gakkai Zasshi. 2006;44:492-8 pubmed
    Recent studies point to a role of Epstein-Barr virus in the pathogenesis of lymphomatoid granulomatosis. Little is however known about the association of the pathogenesis of the disease with Epstein-Barr virus reactivation...
  67. Wyen C, Stenzel W, Hoffmann C, Lehmann C, Deckert M, Fatkenheuer G. Fatal cerebral lymphomatoid granulomatosis in an HIV-1-infected patient. J Infect. 2007;54:e175-8 pubmed
    b>Lymphomatoid granulomatosis (LYG) is a rare systematic lymphoproliferative disorder of uncertain etiology...
  68. Morgan R, Berman J. Anchors away. N Engl J Med. 2007;356:1892-3; author reply 1892-3 pubmed