leukemia p388

Summary

Summary: An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.

Top Publications

  1. Lin S, Wang S, Cheng S, Duh C. Lobocrasol, a new diterpenoid from the soft coral Lobophytum crassum. Org Lett. 2009;11:3012-4 pubmed publisher
    ..Lobocrasol (1), possessing an unprecedented diterpenoid skeleton, was isolated from the soft coral Lobophytum crassum. The structure of lobocrasol was established by extensive analysis of spectroscopic data...
  2. Zhang W, Krohn K, Ding J, Miao Z, Zhou X, Chen S, et al. Structural and stereochemical studies of alpha-methylene-gamma-lactone-bearing cembrane diterpenoids from a south china sea soft coral Lobophytum crassum. J Nat Prod. 2008;71:961-6 pubmed publisher
    ..In a bioassay, sinularolides B and C (1 and 2) and new cembranoids 7 and 8 showed in vitro cytotoxicity against the tumor cell lines A-549 and P-388...
  3. Li G, Huang J, Li Y, Zhang R, Deng B, Zhang J, et al. In vitro study on influence of a discrete nano-hydroxyapatite on leukemia P388 cell behavior. Biomed Mater Eng. 2007;17:321-7 pubmed
    Influence of a discrete nano-hydroxyapatite crystal (nano-HAp) on lymphatic leukemia P388 cell behavior was investigated by an in vitro technique using an MTT test and FITC analysis...
  4. Wang F, Wang L, Yang J, Nomura M, Miyamoto K. Reversal of P-glycoprotein-dependent resistance to vinblastine by newly synthesized bisbenzylisoquinoline alkaloids in mouse leukemia P388 cells. Biol Pharm Bull. 2005;28:1979-82 pubmed
    ..Bisbenzylisoquinoline alkaloids and their derivatives are possible to be good candidates as modifier of MDR in cancer chemotherapy...
  5. Ariyasena J, Baek S, Perry N, Weavers R. Ether-linked biflavonoids from Quintinia acutifolia. J Nat Prod. 2004;67:693-6 pubmed
    ..Structures were determined by spectroscopic methods. This is the first report of biflavonoids from the Grossulariaceae...
  6. Shindo N, Fujimura T, Nojima Kazuno S, Mineki R, Furusawa S, Sasaki K, et al. Identification of multidrug resistant protein 1 of mouse leukemia P388 cells on a PVDF membrane using 6-aminoquinolyl-carbamyl (AQC)-amino acid analysis and World Wide Web (WWW)-accessible tools. Anal Biochem. 1998;264:251-8 pubmed
    ..A database search was carried out with bovine serum albumin as a calibration protein. MDR1 in P388/DOX was ranked first by both databases with high reliability (score 14 for ExPASy, distance 1.34 for EMBL)...
  7. Tan K, Wakimoto T, Takada K, Ohtsuki T, Uchiyama N, Goda Y, et al. Cycloforskamide, a cytotoxic macrocyclic peptide from the sea slug Pleurobranchus forskalii. J Nat Prod. 2013;76:1388-91 pubmed publisher
    ..This novel dodecapeptide contains three d-amino acids and three thiazoline heterocycles and exhibits cytotoxicity against murine leukemia P388 cells, with an IC50 of 5.8 ?M.
  8. Geng Y, Laslo P, Barton K, Wang C. Transcriptional regulation of CD1D1 by Ets family transcription factors. J Immunol. 2005;175:1022-9 pubmed
    ..1-deficient myeloid cells. These findings are the first to demonstrate that Ets proteins are involved in the transcriptional regulation of CD1D1 and that they may function uniquely in different cell types. ..
  9. Sandy M, Han A, Blunt J, Munro M, Haygood M, Butler A. Vanchrobactin and anguibactin siderophores produced by Vibrio sp. DS40M4. J Nat Prod. 2010;73:1038-43 pubmed publisher
    ..In addition to siderophore production, extracts of Vibrio sp. DS40M4 were screened for biologically active molecules; anguibactin was found to be cytotoxic against the P388 murine leukemia cell line (IC(50) < 15 microM). ..

More Information

Publications112 found, 100 shown here

  1. Krasnopolskaya L, Yarina M, Avtonomova A, Usov A, Isakova E, Bukchman V. [Antitumor Activity of Polysaccharides from Ganoderma lucidum Mycelium: in vivo Comparative Study]. Antibiot Khimioter. 2015;60:29-34 pubmed
    ..Sensitivity to xylomannan was more pronounced in adenocarcinoma Ca755 as compared to the T-cell lymphocytic leukemia P388. The antitumor activity of the water soluble polysaccharides total fractions from the mycelium and fruiting ..
  2. Maruyama H, Tamauchi H, Hashimoto M, Nakano T. Antitumor activity and immune response of Mekabu fucoidan extracted from Sporophyll of Undaria pinnatifida. In Vivo. 2003;17:245-9 pubmed
    ..We showed that fucoidan, extracted from dietary seaweed, could inhibit tumor growth. However, the mechanism of Mekabu (Sporophyll of Undaria pinnatifida) fucoidan antitumor activity and how it enhances the immune response remains unknown...
  3. Mitova M, Lang G, Blunt J, Cummings N, Cole A, Robinson W, et al. Cladobotric acids A-F: new cytotoxic polyketides from a New Zealand Cladobotryum sp. J Org Chem. 2006;71:492-7 pubmed
    ..Cladobotric acids A-F (1-6) exhibited notable cytotoxicity against the murine P388 leukemia cell line and were also active against Bacillus subtilis and Candida albicans. ..
  4. Waud W, Gilbert K, Secrist J. Lack of in vivo cross-resistance with 4'-thio-ara-C against drug-resistant murine P388 and L1210 leukemias. Cancer Chemother Pharmacol. 2011;68:399-403 pubmed publisher
  5. Kruczynski A, Etievant C, Perrin D, Chansard N, Duflos A, Hill B. Characterization of cell death induced by vinflunine, the most recent Vinca alkaloid in clinical development. Br J Cancer. 2002;86:143-50 pubmed
    ..Therefore, these data indirectly implicate Bcl-2 and Bfl-1/A1 in vinflunine-induced cell death mechanisms. ..
  6. Tejeda M, Gaal D, Hullan L, Hegymegi Barakonyi B, Kéri G. Evaluation of the antitumor efficacy of the somatostatin structural derivative TT-232 on different tumor models. Anticancer Res. 2006;26:3477-83 pubmed
    ..In our study, the route of infusion was shown to increase drug efficacy relative to conventional delivery methods. Our results suggested that TT-232 is an effective and promising antitumor agent. ..
  7. Cui C, Li X, Li C, Proksch P, Wang B. Cytoglobosins A-G, cytochalasans from a marine-derived endophytic fungus, Chaetomium globosum QEN-14. J Nat Prod. 2010;73:729-33 pubmed publisher
    ..Cytoglobosins C and D (3 and 4) displayed cytotoxic activity against the A-549 tumor cell line...
  8. Huang C, Liaw C, Chen B, Chen P, Su J, Sung P, et al. Withanolide-based steroids from the cultured soft coral Sinularia brassica. J Nat Prod. 2013;76:1902-8 pubmed publisher
    ..The cytotoxicities of compounds 1-7 against a limited panel of cancer cell lines also were determined. ..
  9. Youssef D, Yoshida W, Kelly M, Scheuer P. Cytotoxic cyclic norterpene peroxides from a Red Sea sponge Diacarnus erythraenus. J Nat Prod. 2001;64:1332-5 pubmed
    ..In addition, a new sesquiterpene, O-methyl guaianediol, was isolated. Their structures were determined by means of spectroscopic methods. The cytotoxic activities for the isolated compounds have been reported. ..
  10. Choe Y, Conover C, Wu D, Royzen M, Greenwald R. Anticancer drug delivery systems: N4-acyl poly(ethyleneglycol) prodrugs of ara-C. I. Efficacy in solid tumors. J Control Release. 2002;79:41-53 pubmed
    ..One problematic issue that was identified in this investigation was the need to increase the loading of ara-C onto PEG in order to avoid highly viscous solutions. ..
  11. Kanda Y, Ashizawa T, Kawashima K, Ikeda S, Tamaoki T. Synthesis and antitumor activity of novel C-8 ester derivatives of leinamycin. Bioorg Med Chem Lett. 2003;13:455-8 pubmed
    ..Combination with the modification of the dithiolanone moiety was applied to these C-8 ester derivatives and some of them also showed good antitumor activity. ..
  12. Sahidin -, Hakim E, Juliawaty L, Syah Y, bin Din L, Ghisalberti E, et al. Cytotoxic properties of oligostilbenoids from the tree barks of Hopea dryobalanoides. Z Naturforsch C. 2005;60:723-7 pubmed
    ..Cytotoxic properties of compounds 1-8 were evaluated against murine leukemia P-388 cells. Compound 8 was found to be the most active with IC50 of 5.7 microM. ..
  13. Ueoka R, Ito A, Izumikawa M, Maeda S, Takagi M, Shin ya K, et al. Isolation of azaspiracid-2 from a marine sponge Echinoclathria sp. as a potent cytotoxin. Toxicon. 2009;53:680-4 pubmed publisher
    ..Azaspiracid-2 exhibited potent cytotoxicity against P388 cells with an IC50 value of 0.72 ng/mL and caused S phase arrest on the cell cycle. ..
  14. Feng Y, Blunt J, Cole A, Cannon J, Robinson W, Munro M. Two novel cytotoxic cyclodepsipeptides from a mycoparasitic Cladobotryum sp. J Org Chem. 2003;68:2002-5 pubmed
    ..Compounds 1 and 2 were both cytotoxic against murine P388 leukemia cells. ..
  15. Phifer S, Lee D, Seo E, Kim N, Graf T, Kroll D, et al. Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitiensis. J Nat Prod. 2007;70:954-61 pubmed
    ..2 mg kg-1 per injection when administered intraperitoneally...
  16. Nomura M, Takahashi T, Uesugi A, Tanaka R, Kobayashi S. Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase-3-dependent apoptosis. Anticancer Res. 2008;28:2691-6 pubmed
    ..obliquus sclerotia against mouse leukemia P388 cells was assessed. Cell viability was measured by MTT assay...
  17. Malinowska K, Modranka R, Kubiak K, Mrowicka M, Kędziora J, Klimczak A, et al. [In vitro biological activity of new platinum(II) and palladium(II) complex compounds]. Pol Merkur Lekarski. 2009;26:52-6 pubmed
    ..Based on the MTT tests it may be concluded that compounds 13, 21 and 25 reveal selective cytotoxicity to P388 neoplastic cells. ..
  18. Chen L, Li D, Cai S, Wang F, Xiao X, Gu Q. A new cytotoxic metabolite from a deep sea derived fungus, Phialocephala sp. Yao Xue Xue Bao. 2010;45:1275-8 pubmed
    ..This compound was tested for cytotoxicity against P388 (murine leukemia cell) and K562 (human leukemia cell) cell lines, and displayed strong cytotoxic effects with IC50 value of 0.16 and 0.05 micromol x L(-1), separately. ..
  19. Pettit G, Tan R. Isolation and structure of phakellistatin 14 from the Western Pacific marine sponge Phakellia sp. J Nat Prod. 2005;68:60-3 pubmed
    ..The chirality of each amino acid unit was determined to be S using chiral HPLC methods. Phakellistatin 14 showed cancer cell growth inhibitory activity (ED(50) 5 microg/mL) against the murine lymphocytic leukemia P388 cell line.
  20. Wang X, Yin S, Fan C, Wang F, Lin L, Ding J, et al. Turrapubesins A and B, first examples of halogenated and maleimide-bearing limonoids in nature from Turraea pubescens. Org Lett. 2006;8:3845-8 pubmed
    ..Their absolute configurations were determined by X-ray crystallography of 1 and by CD analysis of a dihydrogenated derivative of 2. Turrapubesin A (1) exhibited weak cytotoxicity against the P-388 tumor cell line. ..
  21. Guo W, Peng J, Zhu T, Gu Q, Keyzers R, Li D. Sorbicillamines A-E, nitrogen-containing sorbicillinoids from the deep-sea-derived fungus Penicillium sp. F23-2. J Nat Prod. 2013;76:2106-12 pubmed publisher
    ..The cytotoxicities of the five new sorbicillin alkaloids against the HeLa, BEL-7402, HEK-293, HCT-116, and P388 cell lines were evaluated. ..
  22. Bai H, Li S, Yin F, Hu L. Isoprenylated naphthoquinone dimers firmianones A, B, and C from Firmiana platanifolia. J Nat Prod. 2005;68:1159-63 pubmed
    ..The absolute configurations of firmianones A and B with a rare hexacyclic skeleton were determined by CD exciton-coupling experiments. Firmianones A and B exhibited moderate cytotoxicity to the P388 cancer cell line. ..
  23. Camoutsis C, Trafalis D, Pairas G, Papageorgiou A. On the formation of 4-[N,N-bis(2-chloroethyl)amino]phenyl acetic acid esters of hecogenin and aza-homo-hecogenin and their antileukemic activity. Farmaco. 2005;60:826-9 pubmed
    ..These results support that the alkylating esters of hecogenin produce important antitumor activity as well as, indicate that the aza-homo-hecogenin ester exhibits significantly higher activity due to lactam group (-NHCO-) modification. ..
  24. Loeffler D, Schoen C, Goebel W, Pilgrim S. Comparison of different live vaccine strategies in vivo for delivery of protein antigen or antigen-encoding DNA and mRNA by virulence-attenuated Listeria monocytogenes. Infect Immun. 2006;74:3946-57 pubmed
    ..Therefore, the results presented here could lay the groundwork for a rational combination of L. monocytogenes as an attenuated carrier for the delivery of protein and nucleic acid vaccines in novel vaccination strategies. ..
  25. Lang G, Mitova M, Cole A, Din L, Vikineswary S, Abdullah N, et al. Pterulamides I-VI, linear peptides from a Malaysian Pterula sp. J Nat Prod. 2006;69:1389-93 pubmed
    ..Furthermore, pterulamides I-V are the first natural peptides with a methylamide C-terminus. Pterulamides I and IV are cytotoxic against the P388 cell line with IC50 values of 0.55 and 0.95 microg/mL (0.79 and 1.33 microM), respectively. ..
  26. Viale M, Vannozzi M, Mandys V, Esposito M. Time-dependent influence of procaine hydrochloride on cisplatin antitumor activity in P388 tumor bearing mice. Anticancer Res. 2001;21:485-7 pubmed
    ..In conclusion procaine hydrochloride increased the antitumor activity of cisplatin independently from its timing of administration, although it seemed to be a better potentiating agent when administered after cisplatin. ..
  27. Budzynska R, Nevozhay D, Kanska U, Jagiello M, Opolski A, Wietrzyk J, et al. Antitumor activity of mannan-methotrexate conjugate in vitro and in vivo. Oncol Res. 2007;16:415-21 pubmed
    ..These results suggest that mannan-methotrexate conjugate should be further investigated as a potential therapeutic agent for intraperitoneally disseminated tumors. ..
  28. Amagata T, Tanaka M, Yamada T, Minoura K, Numata A. Gymnastatins and dankastatins, growth inhibitory metabolites of a gymnascella species from a Halichondria sponge. J Nat Prod. 2008;71:340-5 pubmed publisher
    ..Furthermore, gymnastatin Q ( 3) showed appreciable growth inhibition against BSY-1 (breast) and MKN7 (stomach) human cancer cell lines. ..
  29. Tanjung M, Mujahidin D, Hakim E, Darmawan A, Syah Y. Geranylated flavonols from Macaranga rhizinoides. Nat Prod Commun. 2010;5:1209-11 pubmed
    ..On cytotoxic evaluation against murine leukemia P-388 cells, compounds 1-2 showed IC50 values of 11.4 and 13.9 microM, respectively, while compound 3 was inactive. ..
  30. Hu W, Rao G, Sun Y. Synthesis and antitumor activity of s-tetrazine derivatives. Bioorg Med Chem Lett. 2004;14:1177-81 pubmed
    ..6 microM, 0.6 microM, 0.5 microM and 0.7 microM, respectively. So s-tetrazine derivative is a kind of compound which possesses potential antitumor activities and is worth to research further. ..
  31. Xu Y, Tang C, Ke C, Zhang J, Weiss H, Gesing E, et al. Mono- and Di-sesquiterpenoids from Chloranthus spicatus. J Nat Prod. 2007;70:1987-90 pubmed
    ..Their structures were established by physical data (1D and 2D NMR, MS). The structure and absolute configuration of 1 was confirmed by X-ray crystallography. Compound 1 exhibited moderate in vitro antifungal activity. ..
  32. Roth S, Willcox N, Rzepka R, Mayer M, Melchers I. Major differences in antigen-processing correlate with a single Arg71<-->Lys substitution in HLA-DR molecules predisposing to rheumatoid arthritis and with their selective interactions with 70-kDa heat shock protein chaperones. J Immunol. 2002;169:3015-20 pubmed
    ..They may thus broaden immune responses to pathogens and at least partially explain the distinct contributions of DRB1*0401 and other alleles to disease predisposition. ..
  33. Zhang H, Wang X, Lin L, Ding J, Yue J. Indole alkaloids from three species of the Ervatamia genus: E. officinalis, E. divaricata, and E. divaricata Gouyahua. J Nat Prod. 2007;70:54-9 pubmed
    ..Only the dimeric indole alkaloids showed cytotoxic activities. ..
  34. Chin Y, Salim A, Su B, Mi Q, Chai H, Riswan S, et al. Potential anticancer activity of naturally occurring and semisynthetic derivatives of aculeatins A and B from Amomum aculeatum. J Nat Prod. 2008;71:390-5 pubmed publisher
    ..25, 12.5, 25, and 50 mg/kg. However, when 1 was tested using P388 lymphocytic leukemia and human A2780 ovarian carcinoma in vivo models, it was deemed to be inactive at the doses used...
  35. Alama A, Viale M, Cilli M, Bruzzo C, Novelli F, Tasso B, et al. In vitro cytotoxic activity of tri-n-butyltin(IV)lupinylsulfide hydrogen fumarate (IST-FS 35) and preliminary antitumor activity in vivo. Invest New Drugs. 2009;27:124-30 pubmed publisher
    ..Additional studies are mandatory to unravel the mechanism of action for the development of IST-FS 35 as potential antitumor drug. ..
  36. Yan X, Liu H, Huang H, Li X, Guo Y. Steroids with aromatic A-rings from the Hainan soft coral Dendronephthya studeri Ridley. J Nat Prod. 2011;74:175-80 pubmed publisher
    ..Their structures were elucidated on the basis of detailed spectroscopic analysis and by comparison of their NMR data with those reported in the literature. ..
  37. Pettit G, Tan R, Bao G, Melody N, Doubek D, Gao S, et al. Antineoplastic agents. 587. Isolation and structure of 3-epipancratistatin from Narcissus cv. Ice Follies. J Nat Prod. 2012;75:771-3 pubmed publisher
    ..2-0.69 ?g/mL) some 100× less than that found for pancratistatin (1a) and narciclasine (2), thereby revealing an important configurational requirement in 1a for strong cancer cell growth inhibition...
  38. Kulcsár G, Gaal D, Kulcsár P, Schulcz Á, Czompoly T. A mixture of amino acids and other small molecules present in the serum suppresses the growth of murine and human tumors in vivo. Int J Cancer. 2013;132:1213-21 pubmed publisher
    ..These findings suggest that the AM might offer an interesting perspective in the treatment of cancer and in combination with other treatments may offer hope for a more effective cancer therapy. ..
  39. Aoki N, Kimura S, Takiyama Y, Atsuta Y, Abe A, Sato K, et al. The role of the DAP12 signal in mouse myeloid differentiation. J Immunol. 2000;165:3790-6 pubmed
    ..Collectively, these findings indicate that direct DAP12 signaling has an important role in macrophage differentiation. ..
  40. Bu X, Deady L, Finlay G, Baguley B, Denny W. Synthesis and cytotoxic activity of 7-oxo-7H-dibenz[f,ij]isoquinoline and 7-oxo-7H-benzo[e]perimidine derivatives. J Med Chem. 2001;44:2004-14 pubmed
    ..The 2- and 4-carboxamides showed substantial growth delays against in vivo subcutaneous colon 38 tumors in mice, but the 11-carboxamide had curative activity in this refractory model and is being investigated further. ..
  41. Guo Q, Wu M, Chen Z. Comparison of antitumor effect of recombinant L-asparaginase with wild type one in vitro and in vivo. Acta Pharmacol Sin. 2002;23:946-51 pubmed
    ..Recombinant L-asparaginase markedly inhibited tumors tested in this study and the results strongly suggest that recombinant L-asparaginase has great potential for clinical treatment of these tumors. ..
  42. Nakao Y, Yoshida W, Takada Y, Kimura J, Yang L, Mooberry S, et al. Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis speciosa. J Nat Prod. 2004;67:1332-40 pubmed
    ..Kulokekahilide-2 showed potent cytotoxicity against several cell lines (P388, SK-OV-3, MDA-MB-435, and A-10 with IC50 values ranging from 4.2 to 59.1 nM) indicating cancer cell selectivity. ..
  43. Liu R, Gu Q, Zhu W, Cui C, Fan G, Fang Y, et al. 10-Phenyl-[12]-cytochalasins Z7, Z8, and Z9 from the marine-derived fungus Spicaria elegans. J Nat Prod. 2006;69:871-5 pubmed
    ..All five cytochalasins were evaluated for their cytotoxic effects on P388 and A-549 cell lines by the MTT method. ..
  44. Zhang J, Lautar S, Huang S, Ramsey C, Cheung A, Li J. GPI 6150 prevents H(2)O(2) cytotoxicity by inhibiting poly(ADP-ribose) polymerase. Biochem Biophys Res Commun. 2000;278:590-8 pubmed
    ..GPI 6150 was much less potent to inhibit mono-ADP-ribosyltransferase. There was no selectivity for GPI 6150 between PARP isozymes. These attributes render GPI 6150 a useful tool to probe the functions of PARP. ..
  45. Wu Wong J, Alder J, Alder L, Burns D, Han E, Credo B, et al. Identification and characterization of A-105972, an antineoplastic agent. Cancer Res. 2001;61:1486-92 pubmed
    ..A-105972 and its analogues may be useful for treating cell proliferative disorders such as cancer. ..
  46. Sakio Y, Hirano Y, Hayashi M, Komiyama K, Ishibashi M. Dendocarbins A--N, new drimane sesquiterpenes from the nudibranch Dendrodoris carbunculosa. J Nat Prod. 2001;64:726-31 pubmed
    ..In addition, isodrimeninol (15), the major sesquiterpene of this animal, was found to have a sharp peppery taste. ..
  47. Pettit G, Meng Y, Herald D, Knight J, Day J. Antineoplastic agents. 553. The Texas grasshopper Brachystola magna. J Nat Prod. 2005;68:1256-8 pubmed
    ..magna that does not appear to utilize amaryllis family plants were discussed...
  48. Malmstrøm J, Christophersen C, Barrero A, Oltra J, Justicia J, Rosales A. Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor. J Nat Prod. 2002;65:364-7 pubmed
    ..In the NCI's 60-cell panel, varitriol (1) displayed increased potency toward selected renal, CNS, and breast cancer cell lines. Varixanthone (4) showed antimicrobial activity...
  49. Sera Y, Adachi K, Fujii K, Shizuri Y. A new antifouling hexapeptide from a Palauan sponge, Haliclona sp. J Nat Prod. 2003;66:719-21 pubmed
    ..The structures of hexapeptides 1 and 2 were elucidated by extensive NMR analyses and the advanced Marfey's method with LC/MS. These compounds showed repellent activity against the blue mussel, Mytilus edulis galloprovincialis...
  50. Kawamoto S, Koyano T, Kowithayakorn T, Fujimoto H, Okuyama E, Hayashi M, et al. Wrightiamines A and B, two new cytotoxic pregnane alkaloids from Wrightia javanica. Chem Pharm Bull (Tokyo). 2003;51:737-9 pubmed
    ..Wrightiamine A (1) exhibited cytotoxic activity against vincristine-resistant murine leukemia P388 cells.
  51. Kanska U, Omar M, Budzynska R, Nevozhay D, Jagiello M, Opolski A, et al. Antileukemic activity of glycated fibrinogen-methotrexate conjugates. Anticancer Res. 2005;25:2229-34 pubmed
    ..We expected that conjugates based on glycated fibrinogen would reveal higher antileukemic activity because of decreased plasmin digestibility and a higher retention rate of glycated fibrinogen in the body...
  52. Nevozhay D, Budzynska R, Jagiello M, Kanska U, Omar M, Opolski A, et al. The effect of the substitution level of some dextran-methotrexate conjugates on their antitumor activity in experimental cancer models. Anticancer Res. 2006;26:2179-86 pubmed
    ..However, the difference between the two conjugates was well pronounced in a multiple-dose schedule, when the advantage of T40-MTX over T10-MTX was cumulative during the prolonged course of administration...
  53. Cheng S, Dai C, Duh C. New 4-methylated and 19-oxygenated steroids from the Formosan soft coral Nephthea erecta. Steroids. 2007;72:653-9 pubmed
    ..The structures were elucidated by extensive NMR spectroscopic analysis and their cytotoxicity against selected cancer cells was measured in vitro...
  54. Ueoka R, Nakao Y, Fujii S, van Soest R, Matsunaga S. Aplysinoplides A-C, cytotoxic sesterterpenes from the marine sponge Aplysinopsis digitata. J Nat Prod. 2008;71:1089-91 pubmed publisher
    ..Their structures were determined on the basis of spectroscopic data. They exhibited cytotoxic activity against P388 mouse leukemia cells...
  55. Mitova M, Murphy A, Lang G, Blunt J, Cole A, Ellis G, et al. Evolving trends in the dereplication of natural product extracts. 2. The isolation of chrysaibol, an antibiotic peptaibol from a New Zealand sample of the mycoparasitic fungus Sepedonium chrysospermum. J Nat Prod. 2008;71:1600-3 pubmed publisher
    ..Chrysaibol (1) was cytotoxic against the P388 murine leukemia cell line (IC50 6.61 microM) and showed notable activity against Bacillus subtilis (IC50 1.54 microM)...
  56. Koba M. Application of artificial neural networks for the prediction of antitumor activity of a series of acridinone derivatives. Med Chem. 2012;8:309-19 pubmed
    ..9484. Moreover, the sensitivity analysis indicated that molecular parameters describing geometrical properties as well as lipophilicity of acridinone derivative molecule are important for acridinones antitumor activity...
  57. Isaka M, Suyarnsestakorn C, Tanticharoen M, Kongsaeree P, Thebtaranonth Y. Aigialomycins A-E, new resorcylic macrolides from the marine mangrove fungus Aigialus parvus. J Org Chem. 2002;67:1561-6 pubmed
    ..Hypothemycin and aigialomycin D (5) exhibited in vitro antimalarial activity with IC(50) values of 2.2 and 6.6 microg/mL, respectively, while other analogues were inactive. Cytotoxicities of these compounds were also evaluated...
  58. Duh C, El Gamal A, Chiang C, Chu C, Wang S, Dai C. New cytotoxic xenia diterpenoids from the Formosan soft coral Xenia umbellata. J Nat Prod. 2002;65:1882-5 pubmed
    ..The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro...
  59. Kurosaka K, Takahashi M, Watanabe N, Kobayashi Y. Silent cleanup of very early apoptotic cells by macrophages. J Immunol. 2003;171:4672-9 pubmed
  60. Zeng L, Lan W, Su J, Zhang G, Feng X, Liang Y, et al. Two new cytotoxic tetracyclic tetraterpenoids from the soft coral Sarcophyton tortuosum. J Nat Prod. 2004;67:1915-8 pubmed
    ..The cytotoxic activities of these compounds were carried out in vitro on human nasophyringeal carcinoma (CNE-2) and murine lymphocytic leukemia (P-388) tumor cell lines...
  61. Driniaev V, Mosin V, Krugliak E, Sterlina T, Novik T, Ermakova N, et al. [Antitumor effect of natural avermectins]. Antibiot Khimioter. 2004;49:8-10 pubmed
    ..The highest effect of aversectin C was observed after its intraperitoneal administration. Avermectin B1 inhibited the growth of solid Ehrlich carcinoma and carcinoma 755...
  62. Dalezis P, Geromichalos G, Voyatzi S, Trafalis D, Athanassiou A, Koutsilieris M, et al. Combinational effect of topotecan and octreotide on murine leukemia cells in vivo and in vitro. J BUON. 2006;11:323-7 pubmed
    ..Hereby, we studied the effects of TPT and OCT, and their combination in the treatment of the rodent P388 lymphocytic leukemia, in vitro and in vivo...
  63. Okamoto C, Nakao Y, Fujita T, Iwashita T, van Soest R, Fusetani N, et al. Cytotoxic C47-polyacetylene carboxylic acids from a marine sponge Pertrosia sp. J Nat Prod. 2007;70:1816-9 pubmed
    ..Absolute stereochemistry of 3 was assigned by application of the modified Mosher analysis. Petroformynic acids exhibit moderate cytotoxic activity against P388 cells...
  64. Dias D, Urban S. Phytochemical investigation of the Australian lichens Ramalina glaucescens and Xanthoria parietina. Nat Prod Commun. 2009;4:959-64 pubmed
    ..Of these, (+)-usnic acid 1 displayed the most significant antitumor and antibacterial activities...
  65. Lin C, Ren S, Zhang L, Jin H, Sun J, Zuo Y. Extracellular ATP induces CD44 shedding from macrophage-like P388D1 cells via the P2X7 receptor. Hematol Oncol. 2012;30:70-5 pubmed publisher
    ..In addition, using a receptor inhibitor and P2X7R short hairpin RNA, we showed that the loss of CD44 is mediated via the P2X7R. Finally, we demonstrated that activation of P2X7R by ATP induces CD44 shedding...
  66. Risbud M, Bhonde M, Bhonde R. Chitosan-polyvinyl pyrrolidone hydrogel does not activate macrophages: potentials for transplantation applications. Cell Transplant. 2001;10:195-202 pubmed
    ..Our results indicate that this hydrogel could be a potential candidate for transplantation studies by virtue of its biocompatibility and imunocompatibility...
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