leukemia l5178


Summary: An experimental lymphocytic leukemia of mice.

Top Publications

  1. Karawita R, Senevirathne M, Athukorala Y, Affan A, Lee Y, Kim S, et al. Protective effect of enzymatic extracts from microalgae against DNA damage induced by H2O2. Mar Biotechnol (NY). 2007;9:479-90 pubmed
    ..Therefore, microalgae such as P. duplex may be an excellent source of naturally occurring antioxidant compounds with potent DNA damage inhibition potential. ..
  2. Levi B, Werman M. Fructose and related phosphate derivatives impose DNA damage and apoptosis in L5178Y mouse lymphoma cells. J Nutr Biochem. 2003;14:49-60 pubmed
    ..Taken together, these results suggest that fructose triggers deleterious modification in cultured cells through the glycation process, and thus should deserve more attention as an agent that may induce physiological complications. ..
  3. Möller M, Adam W, Marquardt S, Saha Möller C, Stopper H. Cytotoxicity and genotoxicity induced by the photochemical alkoxyl radical source N-tert-butoxypyridine-2-thione in L5178Y mouse lymphoma cells under UVA irradiation. Free Radic Biol Med. 2005;39:473-82 pubmed
    ..These results demonstrate that N-alkoxypyridinethiones are useful photochemical sources of oxyl and thiyl radicals to elucidate biological effects caused by these free radicals. ..
  4. Pottenger L, Schisler M, Zhang F, Bartels M, Fontaine D, McFadden L, et al. Dose-response and operational thresholds/NOAELs for in vitro mutagenic effects from DNA-reactive mutagens, MMS and MNU. Mutat Res. 2009;678:138-47 pubmed publisher
  5. Doppalapudi R, Riccio E, Rausch L, Shimon J, Lee P, Mortelmans K, et al. Evaluation of chemopreventive agents for genotoxic activity. Mutat Res. 2007;629:148-60 pubmed
    ..The results with geraniol remain inconclusive. I3C, BBIC and BTP were not tested in the chromosomal aberration assay. None of the 11 agents induced micronuclei in mouse bone marrow erythrocytes...
  6. Liechty M, Scalzi J, Sims K, Crosby H, Spencer D, Davis L, et al. Analysis of large and small colony L5178Y tk-/- mouse lymphoma mutants by loss of heterozygosity (LOH) and by whole chromosome 11 painting: detection of recombination. Mutagenesis. 1998;13:461-74 pubmed
    ..The most common finding was that large regions of LOH do not result from deletions, demonstrating that these cells can detect recombination events as well as previously observed chromosomal rearrangements, deletions and point mutations...
  7. Honma M, Momose M, Sakamoto H, Sofuni T, Hayashi M. Spindle poisons induce allelic loss in mouse lymphoma cells through mitotic non-disjunction. Mutat Res. 2001;493:101-14 pubmed
    ..Our present study indicates that spindle poisons induce mutations through mitotic non-disjunction without structural DNA changes and supports a possible mechanism in which a recessive mutation mediated by aneuploidy may develop tumors...
  8. Chen T, Harrington Brock K, Moore M. Mutant frequencies and loss of heterozygosity induced by N-ethyl-N-nitrosourea in the thymidine kinase gene of L5178Y/TK(+/-)-3.7.2C mouse lymphoma cells. Mutagenesis. 2002;17:105-9 pubmed
    ..This study serves to verify that the MLA detects both point mutations and chromosomal mutations...
  9. Soriano C, Creus A, Marcos R. Arsenic trioxide mutational spectrum analysis in the mouse lymphoma assay. Mutat Res. 2008;646:1-7 pubmed publisher
    ..Our results show that, in mouse lymphoma cells, ATO is a strong clastogenic compound inducing large deletions, at chromosomal level, covering the Tk gene, as well as other regions of chromosome 11. ..

More Information

Publications103 found, 100 shown here

  1. Zupko I, Réthy B, Hohmann J, Molnar J, Ocsovszki I, Falkay G. Antitumor activity of alkaloids derived from Amaryllidaceae species. In Vivo. 2009;23:41-8 pubmed
    ..The apoptosis-inducing activities of selected agents (2-O-acetyllycorine and trisphaeridine) were measured via acridine orange and ethidium bromide dual staining and flow cytometry of the subG1 population...
  2. Liechty M, Hassanpour Z, Hozier J, Clive D. Use of microsatellite DNA polymorphisms on mouse chromosome 11 for in vitro analysis of thymidine kinase gene mutations. Mutagenesis. 1994;9:423-7 pubmed
    ..Therefore, the ability to detect loss of heterozygosity in the mouse lymphoma assay will make the assay an extremely valuable tool in the detection of agents capable of inducing loss of heterozygosity. ..
  3. Jackman A, Kimbell R, Aherne G, Brunton L, Jansen G, Stephens T, et al. Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase. Clin Cancer Res. 1997;3:911-21 pubmed
    ..At higher doses, significant weight loss (gastrointestinal toxicity) and myelosuppression (neutropenia and thrombocytopenia) were observed, suggesting that these may be dose-limiting toxicities in the Phase I clinical studies. ..
  4. Kruszewski M, Iwanenko T, Bouzyk E, Szumiel I. Chelating of iron and copper alters properties of DNA in L5178Y cells, as revealed by the comet assay. Mutat Res. 1999;434:53-60 pubmed
    ..The presence of the latter is indicated by the increase in micronuclei frequency. These results support the postulated differential role of iron and copper ions in maintaining the higher order DNA structure in LY sublines. ..
  5. Buhtoiarov I, Lum H, Berke G, Paulnock D, Sondel P, Rakhmilevich A. CD40 ligation activates murine macrophages via an IFN-gamma-dependent mechanism resulting in tumor cell destruction in vitro. J Immunol. 2005;174:6013-22 pubmed
    ..IFN-gamma production by macrophages was dependent on IL-12. Taken together, the results show that murine macrophages are activated directly by anti-CD40 mAb to secrete IFN-gamma and mediate tumor cell destruction. ..
  6. Schroder H, Merz H, Steffen R, Muller W, Sarin P, Trumm S, et al. Differential in vitro anti-HIV activity of natural lignans. Z Naturforsch C. 1990;45:1215-21 pubmed
    ..Our results suggest that both compounds prevent the increase of topoisomerase II activity, involved in virus replication, after infection of cells with HIV-1. ..
  7. Evans H, Evans T, Horng M. Antimutagenicity of WR-1065 in L5178Y cells exposed to accelerated (56)Fe ions. Radiat Res. 2002;158:110-4 pubmed
    ..The results indicate that the mechanisms involved differ in the protection against cytotoxic compared to mutagenic effects and in the protection against damage caused by accelerated (56)Fe ions compared to X radiation...
  8. Oakes D, Ritchie H, Woodman P, Narup E, Moscova M, Picker K, et al. Genotoxicity studies of a desealant solvent mixture, SR-51. Toxicol Ind Health. 2009;25:5-13 pubmed publisher
    ..In conclusion, there was no evidence that SR-51 is mutagenic. ..
  9. Aly A, Edrada Ebel R, Wray V, Muller W, Kozytska S, Hentschel U, et al. Bioactive metabolites from the endophytic fungus Ampelomyces sp. isolated from the medicinal plant Urospermum picroides. Phytochemistry. 2008;69:1716-25 pubmed publisher
    ..picroides thereby indicating that the production of bioactive natural products by the endophyte proceeds also under in situ conditions within the host plant. ..
  10. Han T, Wang J, Tong W, Moore M, Fuscoe J, Chen T. Microarray analysis distinguishes differential gene expression patterns from large and small colony Thymidine kinase mutants of L5178Y mouse lymphoma cells. BMC Bioinformatics. 2006;7 Suppl 2:S9 pubmed
  11. Whittaker P, Clarke J, San R, Begley T, Dunkel V. Evaluation of the butter flavoring chemical diacetyl and a fluorochemical paper additive for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells. Food Chem Toxicol. 2008;46:2928-33 pubmed publisher
    ..The increase in the frequency of small colonies in the assay with diacetyl indicates that diacetyl causes damage to multiple loci on chromosome 11 in addition to functional loss of the thymidine kinase locus. ..
  12. Réthy B, Hohmann J, Minorics R, Varga A, Ocsovszki I, Molnar J, et al. Antitumour properties of acridone alkaloids on a murine lymphoma cell line. Anticancer Res. 2008;28:2737-43 pubmed
    ..Naturally occurring acridone alkaloids exhibit a beneficial combination of anticancer effects and, accordingly, the acridone skeleton can be considered useful in the design of novel antiproliferative agents. ..
  13. Smart D, Ahmedi K, Harvey J, Lynch A. Genotoxicity screening via the ?H2AX by flow assay. Mutat Res. 2011;715:25-31 pubmed publisher
    ..Nevertheless, the ?H2AX by flow assay represents a novel genotoxicity assay with the potential to flag both pro- and proximate genotoxins. ..
  14. McCarroll N, Protzel A, Ioannou Y, Frank Stack H, Jackson M, Waters M, et al. A survey of EPA/OPP and open literature on selected pesticide chemicals. III. Mutagenicity and carcinogenicity of benomyl and carbendazim. Mutat Res. 2002;512:1-35 pubmed
    ..The deficiencies in defining the MOA for benomyl/MBC introduce uncertainties into the analysis; consequently, benomyl/MBC induction of aneuploidy cannot be definitively linked to mouse liver carcinogenicity at this time...
  15. Smith C, O Donovan M, Martin E. hOGG1 recognizes oxidative damage using the comet assay with greater specificity than FPG or ENDOIII. Mutagenesis. 2006;21:185-90 pubmed
    ..The use of hOGG1 in the modified comet assay offers a useful alternative to FPG and is apparently more specific for 8-oxoguanine and methyl-fapy-guanine. ..
  16. Ribeiro D, Marques M, Salvadori D. Biocompatibility of glass-ionomer cements using mouse lymphoma cells in vitro. J Oral Rehabil. 2006;33:912-7 pubmed
    ..5% for Vitrebond. Taken together, these results support the notion that some components of glass-ionomer cements show both genotoxic and cytotoxic effects in higher concentrations. ..
  17. Molnar J, Engi H, Mandi Y, Somlai C, Penke B, Szabo A, et al. Effects of nontoxic heat shock protein 90 inhibitor peptide derivatives on reversal of MDR of tumor cells. In Vivo. 2007;21:429-33 pubmed
    ..It is suggested that the MDR reversal effects of these anticancer peptide derivatives, together with their antiproliferative effects on lung cancer cells, may open up new horizons in cancer chemotherapy. ..
  18. Geter D, Zhang F, Schisler M, Wood A, Kan H, Jeong Y, et al. Genetic damage, but limited evidence of oxidative stress markers in diethyl maleate-induced glutathione depleted mouse lymphoma L5178Y (TK(+/-)) cell cultures. Toxicol Mech Methods. 2012;22:547-54 pubmed publisher
    ..These results demonstrate an association between DEM-induced genotoxicity and GSH depletion in mouse lymphoma L5178Y (TK(+/-)) cells, but not with other oxidative markers. ..
  19. Kruszewski M, Wojewodzka M, Iwanenko T, Szumiel I, Okuyama A. Differential inhibitory effect of OK-1035 on DNA repair in L5178Y murine lymphoma sublines with functional or defective repair of double strand breaks. Mutat Res. 1998;409:31-6 pubmed
    ..These results may indicate that the DSB repair defect previously identified in LY-S cells is due to a lack of function of DNA-PK or its impaired activation in the irradiated cells. ..
  20. Sriram V, Cho S, Li P, O Donnell P, Dunn C, Hayakawa K, et al. Inhibition of glycolipid shedding rescues recognition of a CD1+ T cell lymphoma by natural killer T (NKT) cells. Proc Natl Acad Sci U S A. 2002;99:8197-202 pubmed
    ..These results suggest that one means by which certain tumor cells can evade the host's innate antitumor immune response is by shedding glycolipids that inhibit CD1-mediated antigen presentation to NKT cells. ..
  21. Kleczkowska H, Malanga M, Szumiel I, Althaus F. Poly ADP-ribosylation in two L5178Y murine lymphoma sublines differentially sensitive to DNA-damaging agents. Int J Radiat Biol. 2002;78:527-34 pubmed
    ..The results demonstrate disturbances in the poly ADP-ribosylation response of the radiosensitive LY-S cells and reduced poly(ADP-ribose)-binding affinity of the nuclear matrix of these cells. ..
  22. Gallo S, Atifi S, Mahamoud A, Santelli Rouvier C, Wolfart K, Molnar J, et al. Synthesis of aza mono, bi and tricyclic compounds. Evaluation of their anti MDR activity. Eur J Med Chem. 2003;38:19-26 pubmed
    ..Anti MDR activity of a series of acridine, pyridoquinoline, quinoline and pyridine analogous amines was evaluated. Interesting activity is displayed by tricyclic compounds. Besides ring size, influence of the side chain was studied. ..
  23. Butterworth B, Mathre O, Ballinger K, Adalsteinsson O. Contamination is a frequent confounding factor in toxicology studies with anthraquinone and related compounds. Int J Toxicol. 2004;23:335-44 pubmed
    ..Although AQ-OX is no longer commercially used in the United States, many of the reported genotoxicity and carcinogenicity results in the literature for AQ and AQ derivative compounds must be viewed with caution. ..
  24. Bringmann G, Mutanyatta Comar J, Maksimenka K, Wanjohi J, Heydenreich M, Brun R, et al. Joziknipholones A and B: the first dimeric phenylanthraquinones, from the roots of Bulbine frutescens. Chemistry. 2008;14:1420-9 pubmed
    ..Joziknipholones A and B are active against the chloroquine resistant strain K1 of the malaria pathogen, Plasmodium falciparum, and show moderate activity against murine leukemic lymphoma L5178y cells. ..
  25. Scott A, Orsi A, Ward C, Bradford R. Genotoxicity testing of a Hoodia gordonii extract. Food Chem Toxicol. 2012;50 Suppl 1:S34-40 pubmed publisher
    ..H. gordonii extract was shown to be non-genotoxic in 3 independent assays (a bacterial mutation test, a gene mutation assay using mouse lymphoma cells and a bone marrow micronucleus assay in the mouse). ..
  26. Kruszewski M, Zastawny T, Szumiel I. Repair of gamma-ray-induced base damage in L5178Y sublines is damage type-dependent and unrelated to radiation sensitivity. Acta Biochim Pol. 2001;48:525-33 pubmed
  27. Misbahi H, Brouant P, Hever A, Molnár A, Wolfard K, Spengler G, et al. Benzo[b]-1,8-naphthyridine derivatives: synthesis and reversal activity on multidrug resistance. Anticancer Res. 2002;22:2097-101 pubmed
    ..Most of the compounds tested reversed the MDR of tumour cells more effectively than the reference drugs did and they showed more potent chemosensitizing activity than phenothiazine and acridine derivatives have. ..
  28. Nagy B, Mucsi I, Molnar J, Varga A, Thurzo L. Chemosensitizing effect of vitamin C in combination with 5-fluorouracil in vitro. In Vivo. 2003;17:289-92 pubmed
    ..One of the mechanisms by which vitamin C potentiates cytostatics could be apoptosis induction. ..
  29. Cheng T, Patton G, Muldoon Jacobs K. Can the L5178Y Tk+/- mouse lymphoma assay detect epigenetic silencing?. Food Chem Toxicol. 2013;59:187-90 pubmed publisher
    ..This brief article highlights the studies that have contributed to this conjecture and suggests an addition to the experimental design that could identify if the test substance is a potential epimutagen acting via hypermethylation. ..
  30. Storer R, Kraynak A, McKelvey T, Elia M, Goodrow T, DeLuca J. The mouse lymphoma L5178Y Tk+/- cell line is heterozygous for a codon 170 mutation in the p53 tumor suppressor gene. Mutat Res. 1997;373:157-65 pubmed
    ..These results indicate that p53 protein in L5178Y cells is dysfunctional and suggest that this line may therefore be abnormally susceptible to the induction of genetic alterations. ..
  31. Maeda K, Nishiyama C, Tokura T, Akizawa Y, Nishiyama M, Ogawa H, et al. Regulation of cell type-specific mouse Fc epsilon RI beta-chain gene expression by GATA-1 via four GATA motifs in the promoter. J Immunol. 2003;170:334-40 pubmed
    ..These results indicate that cell type-specific transcription of mouse beta-chain gene is regulated by GATA-1. ..
  32. Chen A, Liu S, Park D, Kang Y, Zheng G. Depleting intratumoral CD4+CD25+ regulatory T cells via FasL protein transfer enhances the therapeutic efficacy of adoptive T cell transfer. Cancer Res. 2007;67:1291-8 pubmed
    ..Hence, our study shows for the first time that using FasL to predeplete intratumoral Treg provides a useful means for optimizing adoptive therapy. ..
  33. Doherty A, Hayes J, Fellows M, Kirk S, O Donovan M. A rapid, semi-automated method for scoring micronuclei in mononucleated mouse lymphoma cells. Mutat Res. 2011;726:36-41 pubmed publisher
    ..Although optimised for mouse lymphoma cells, it should be simple to adapt the method for any cell type growing in suspension. ..
  34. Evans H, Nielsen M, Mencl J, Horng M, Ricanati M. The effect of dose rate on X-radiation-induced mutant frequency and the nature of DNA lesions in mouse lymphoma L5178Y cells. Radiat Res. 1990;122:316-25 pubmed
    ..The reason for these apparently conflicting results concerning the effect of DNA repair on the induction of extended lesions is under investigation. ..
  35. Kim J, Kwon J, Kim J, Koh W, Chung M, Yoon S, et al. Identification of potential biomarkers of genotoxicity and carcinogenicity in L5178Y mouse lymphoma cells by cDNA microarray analysis. Environ Mol Mutagen. 2005;45:80-9 pubmed
    ..Taken together, these results suggest that gene expression profiling in mouse lymphoma cells can provide valuable information for the evaluation of potential genotoxicity but may have limitations in predicting carcinogenicity. ..
  36. Pohl C, Priestley C, O Donovan M, Bolcsfoldi G, Fred C. Optimization of a radiolabel DNA-binding assay in cultured mammalian cells. Mutat Res. 2011;723:134-41 pubmed publisher
    ..2%). The detection level is approximately 2adducts/10(8) dNTP. ..
  37. Wang L, White J, Capizzi R. The effect of ara-C-induced inhibition of DNA synthesis on its cellular pharmacology. Cancer Chemother Pharmacol. 1990;25:418-24 pubmed
    ..This inhibition may account for the plateau in the accumulation of ara-CDNA that was observed at 3 h and suggests that ara-C incorporation may be self-limiting at high cellular concentrations of ara-CTP.(ABSTRACT TRUNCATED AT 400 WORDS)..
  38. Nakamura N, Sawada S. Reversed dose-rate effect and RBE of 252-californium radiation in the induction of 6-thioguanine-resistant mutations in mouse L5178Y cells. Mutat Res. 1988;201:65-71 pubmed
    ..Since one-third of 252Cf radiation consists of gamma-rays, the relative biological effectiveness (RBE) of 252Cf neutrons would be even greater, 16 or more, for mutation induction in the present assay...
  39. Zastawny T, Kruszewski M, Olinski R. Ionizing radiation and hydrogen peroxide induced oxidative DNA base damage in two L5178Y cell lines. Free Radic Biol Med. 1998;24:1250-5 pubmed
    ..The yields of damaged bases were related to cellular sensitivity to damaging agent; this observation points to a relationship between DNA base damage induction, antioxidant defense system in the intracellular milieu and cell sensitivity...
  40. Allen J, Campbell J, Cariello N, Kutz S, Thilagar A, Xu J, et al. Genetic toxicology of remifentanil, an opiate analgesic. Teratog Carcinog Mutagen. 2003;Suppl 1:137-49 pubmed
    ..A weight-of-evidence analysis, taking into consideration genotoxic mechanisms, in vivo results, and the conditions of clinical use, suggests remifentanil does not pose a genotoxic risk to patients...
  41. Kruszewski M, Iwaneńko T. Labile iron pool correlates with iron content in the nucleus and the formation of oxidative DNA damage in mouse lymphoma L5178Y cell lines. Acta Biochim Pol. 2003;50:211-5 pubmed
    ..The critical factor appears to be the availability of transition metal ions that take part in the OH radical-generating Fenton reaction (very likely in the form of LIP)...
  42. Gradzka I, Buraczewska I, Kuduk Jaworska J, Romaniewska A, Szumiel I. Radiosensitizing properties of novel hydroxydicarboxylatoplatinum(II) complexes with high or low reactivity with thiols: two modes of action. Chem Biol Interact. 2003;146:165-77 pubmed
    ..It shows a considerable ability to arrest cells in G2 phase. We assume that Pt4 pre-treatment arrests cells in G2 phase and thus sensitizes to X-rays these cells that have a radiosensitive G2 phase (mode (ii) of action)...
  43. Szczygiel D, Pawlus J, Plonka P, Elas M, Szczygiel M, Plonka B, et al. Nitric oxide complexes in the interaction between primary and secondary tumor of L5178Y lymphoma. Nitric Oxide. 2004;11:279-89 pubmed
    ..This is the first EPR study on "concomitant immunity" in regard to tumor-tumor and tumor-ascites interactions in vivo...
  44. Minami Y, Kimura Y, Kawasaki H, Suzuki K, Yahara I. The carboxy-terminal region of mammalian HSP90 is required for its dimerization and function in vivo. Mol Cell Biol. 1994;14:1459-64 pubmed
    ..The carboxy-terminally truncated human HSP90 alpha neither formed dimers in yeast cells nor rescued the lethal double mutant...
  45. McIlrath J, Bouffler S, Samper E, Cuthbert A, Wojcik A, Szumiel I, et al. Telomere length abnormalities in mammalian radiosensitive cells. Cancer Res. 2001;61:912-5 pubmed
    ..Telomere length abnormalities observed in radiosensitive cells suggest that these two phenotypes may be linked...
  46. Yamazaki T, Akiba H, Iwai H, Matsuda H, Aoki M, Tanno Y, et al. Expression of programmed death 1 ligands by murine T cells and APC. J Immunol. 2002;169:5538-45 pubmed
    ..The inducible expression of PD-1 ligands on both T cells and APCs may suggest new paradigms of PD-1-mediated immune regulation...
  47. Molnar J, Molnar A, Mucsi I, Pinter O, Nagy B, Varga A, et al. Reversal of multidrug resistance in mouse lymphoma cells by phenothiazines. In Vivo. 2003;17:145-9 pubmed
    ..Our results demonstrate that MDR can be reversed by interaction of various compounds with Pgp or by modification of the membrane structure around the Pgp...
  48. Clark L, Harrington Brock K, Wang J, Sargent L, Lowry D, Reynolds S, et al. Loss of P53 heterozygosity is not responsible for the small colony thymidine kinase mutant phenotype in L5178Y mouse lymphoma cells. Mutagenesis. 2004;19:263-8 pubmed
    ..7.2C mouse lymphoma cells. From all of these analyses we can conclude that the small colony mutant phenotype is not caused by deletion of both Trp53 and Tk1...
  49. Shuai P, Zhang L, Wang Y. [TK locus mutation assay: comparison of L5178Y and TK6 cell lines]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2004;35:650-3 pubmed
    ..To compare the advantages and disadvantages of utilizing L5178Y and TK6 cell lines in the TK locus mutation assay...
  50. Aly A, Debbab A, Edrada Ebel R, Wray V, Muller W, Lin W, et al. A new tetrahydrofuran derivative from the endophytic fungus Chaetomium sp. isolated from Otanthus maritimus. Z Naturforsch C. 2009;64:350-4 pubmed
    ..Compounds 2 and 6 showed significant growth inhibition against L5178Y cells with EC50 values of 7.0 and 2.7 microg/mL, respectively, whereas 1 was inactive...
  51. Fellows M, O Donovan M. Etoposide, cadmium chloride, benzo[a]pyrene, cyclophosphamide and colchicine tested in the in vitro mammalian cell micronucleus test (MNvit) in the presence and absence of cytokinesis block using L5178Y mouse lymphoma cells and 2-aminoanthracene test. Mutat Res. 2010;702:163-70 pubmed publisher
    ..Accordingly, this work supports the premise that relative population doublings and relative increase in cell counts are appropriate measures of toxicity for the non-cytokinesis-blocked in vitro micronucleus assay...
  52. Mei N, Hu J, Xia Q, Fu P, Moore M, Chen T. Cytotoxicity and mutagenicity of retinol with ultraviolet A irradiation in mouse lymphoma cells. Toxicol In Vitro. 2010;24:439-44 pubmed publisher
    ..These results suggest that retinol is mutagenic when exposed to UVA in mouse lymphoma cells through a clastogenic mode-of-action...
  53. Hozier J, Scalzi J, Sawyer J, Carley N, Applegate M, Clive D, et al. Localization of the mouse thymidine kinase gene to the distal portion of chromosome 11. Genomics. 1991;10:827-30 pubmed
  54. Froese G, Berczi I, Israels L. Tumour cell-antibody interactions. I. In vivo experiments. Immunology. 1982;45:303-12 pubmed
    ..It is suggested that a rapid neutralization and degradation of antibody by the target tissue prevents its accumulation in tumour nodules...
  55. Clark L, Hart D, Vojta P, Harrington Brock K, Barrett J, Moore M, et al. Identification and chromosomal assignment of two heterozygous mutations in the Trp53 gene in L5178Y/Tk(+/-)-3.7.2C mouse lymphoma cells. Mutagenesis. 1998;13:427-34 pubmed
  56. Frieauff W, Hartmann A, Suter W. Automatic analysis of slides processed in the Comet assay. Mutagenesis. 2001;16:133-7 pubmed
    ..The possibility of analyzing 50 samples within 1 day and the high reproducibility of results make automated image processing a powerful tool for automatic analysis of slides processed in the Comet assay...
  57. Toriya M, Yamamoto M, Saeki K, Fujii Y, Matsumoto K. Antitumor effect of photodynamic therapy with zincphyrin, zinc-coproporphyrin III, in mice. Biosci Biotechnol Biochem. 2001;65:363-70 pubmed
    ..In contrast, all animals receiving 100 mg/kg of Hp under the same conditions died. These results indicate that Zincphyrin would be a useful photosensitizer with low phototoxicity...
  58. Hess J, Clark L, Moore M. Trp53 sequence analysis of L5178Y cell line derivatives. Environ Mol Mutagen. 2003;42:122-4 pubmed
  59. Gyemant N, Tanaka M, Molnar P, Deli J, Mandoky L, Molnar J. Reversal of multidrug resistance of cancer cells in vitro: modification of drug resistance by selected carotenoids. Anticancer Res. 2006;26:367-74 pubmed
    ..The enhanced antiproliferative activity of epirubicin combinated with (9Z)-Violaxanthin was more significant on MCF7 cells resistant to anthracycline...
  60. Begleiter A, Pugh L, Israels L, Johnston J. Enhanced cytotoxicity and inhibition of DNA damage repair in irradiated murine L5178Y lymphoblasts and human chronic lymphocytic leukemia cells treated with 2'-deoxycoformycin and deoxyadenosine in vitro. Cancer Res. 1988;48:3981-6 pubmed
    ..These results suggest that 2'-deoxycoformycin/deoxyadenosine can function as a radiosensitizer, and this effect is associated with the cellular accumulation of dATP and inhibition of repair of DNA single strand breaks...
  61. Altevogt P, Fogel M, Cheingsong Popov R, Dennis J, Robinson P, Schirrmacher V. Different patterns of lectin binding and cell surface sialylation detected on related high- and low-metastatic tumor lines. Cancer Res. 1983;43:5138-44 pubmed
    ..It is proposed that the differences in positioning of SA on the cell surface leading to masking or unmasking of terminal sugars could influence the metastatic potential of tumor cells...
  62. Dunkel V, San R, Seifried H, Whittaker P. Genotoxicity of iron compounds in Salmonella typhimurium and L5178Y mouse lymphoma cells. Environ Mol Mutagen. 1999;33:28-41 pubmed
    ..The LED ratio ranges from 1 for FeSO4 to 30 for carbonyl Fe, which are similar to oral LD50 values obtained in animal studies...
  63. Mueller S, Stopper H. Characterization of the genotoxicity of anthraquinones in mammalian cells. Biochim Biophys Acta. 1999;1428:406-14 pubmed
    ..These data support the idea that inhibition of the catalytic activity of topoisomerase II contributes to anthraquinone-induced genotoxicity and mutagenicity...
  64. Nakayama M, Ishidoh K, Kojima Y, Harada N, Kominami E, Okumura K, et al. Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death. J Immunol. 2003;170:341-8 pubmed
    ..These results revealed that the multiple pathways of TWEAK-induced cell death are solely mediated by Fn14...
  65. Gregory M, Koh S, Huang E, Saff R, Marshak Rothstein A, Mukai S, et al. A novel treatment for ocular tumors using membrane FasL vesicles to activate innate immunity and terminate immune privilege. Invest Ophthalmol Vis Sci. 2005;46:2495-502 pubmed
  66. Rakhmilevich A, Buhtoiarov I, Malkovsky M, Sondel P. CD40 ligation in vivo can induce T cell independent antitumor effects even against immunogenic tumors. Cancer Immunol Immunother. 2008;57:1151-60 pubmed publisher
    ..Taken together, our results indicate that antitumor effects induced by alphaCD40, even against immunogenic tumors, can be observed in the absence of T cells and may involve macrophages...
  67. Hou Y, Yang L, Mou M, Hou Y, Zhang A, Pan N, et al. Annexin A2 regulates the levels of plasmin, S100A10 and Fascin in L5178Y cells. Cancer Invest. 2008;26:809-15 pubmed publisher
    ..The detailed mechanism for the regulations above remains to be further investigated, but our results show the potential of ANXA2 as a new target molecule for the strategies of tumor biotherapy or tumor gene therapy...
  68. Struwe M, Csato M, Singer T, Gocke E. Comprehensive assessment of the photomutagenicity, photogenotoxicity and photo(cyto)toxicity of azulene. Mutat Res. 2011;723:129-33 pubmed publisher
    ..Weak photo(cyto)toxicity (estimate of PIF?1.67) was observed with azulene in the 3T3 NRU test, the Alamar Blue test and the relative cell count, which may be due to the generation of reactive oxygen species, as reported recently...
  69. Martins A, Dymek A, Handzlik J, Spengler G, Armada A, Molnar J, et al. Activity of fourteen new hydantoin compounds on the human ABCB1 efflux pump. In Vivo. 2012;26:293-7 pubmed
    ..The overexpression of an ABC transporter, the ABCB1, is often associated with MDR in cancer. Previously it was observed that hydantoin compounds can modulate the activity of the ABCB1 pump...
  70. Froese G, Berczi I, Israels L. Tumour cell-antibody interactions. II. In vitro studies. Immunology. 1982;45:313-23 pubmed
    ..Cells fixed with 10% formalin bound maximum amounts of antibody were incapable of digesting antibody even at 37 degrees and did not release immune complexes. These findings are of relevance to cancer immunodiagnosis and immunotherapy...
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    ..Assays for interactions with DNA and RNA revealed that the antiproliferative effects of lycorine and haemanthamine result from their complex formation with RNA...
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    ..Such results indicate that these two compounds may cause a different type of DNA damage and/or that the DNA damage caused by the palladium(II) compound was dealt with in a different manner from that induced by the platinum(II) complex...
  73. Jacobi Elizondo J, Gomez Flores R, Tamez Guerra R, Rodriguez Padilla C, Heredia Rojas J. Acute effects of 60-Hz electromagnetic fields on ex vivo murine lymphocyte and macrophage functions, and in vitro tumor cell growth. Rev Latinoam Microbiol. 2001;43:130-4 pubmed
    ..We observed that exposure to EMF did not alter lymphocyte and macrophage functions, and did not affect in vitro cell growth of the murine lymphoma cell line L5178Y-R...
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    ..We discuss that lethal lesions produced by indirect actions in L5178Y and XRCC4-complemented M10 cells may differ, at least in part, from DNA double-strand breaks repairable by non-homologous end joining...
  75. Brink A, Richter I, Lutz U, Wanek P, Stopper H, Lutz W. Biological significance of DNA adducts: comparison of increments over background for various biomarkers of genotoxicity in L5178Y tk(+/-) mouse lymphoma cells treated with hydrogen peroxide and cumene hydroperoxide. Mutat Res. 2009;678:123-8 pubmed publisher
    ..In comparison with data obtained with the methylating agent methyl methanesulfonate we further conclude that the assumption of DNA adducts being oversensitive biomarkers is adduct-specific...
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    ..Furthermore, the search for compounds that regulate and overcome apoptosis deficiency of cancer cells is also of great therapeutic importance...
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    ..8 micrograms/ml) followed by hymenialdisine and 3-bromohymenialdisine, which were essentially equitoxic and exhibited ED50s of 3.9 micrograms/ml in both cases. The remaining alkaloids were inactive against this cell line...
  78. Itoh T, Shiomi T, Shiomi N, Harada Y, Wakasugi M, Matsunaga T, et al. Rodent complementation group 8 (ERCC8) corresponds to Cockayne syndrome complementation group A. Mutat Res. 1996;362:167-74 pubmed
    ..Complementation tests by cell fusion and transfection using 6L1030 cells revealed that rodent complementation group 8 corresponded to CS complementation group A...
  79. Stopper H, Mueller S, Lutz W. Supra-additive genotoxicity of a combination of gamma-irradiation and ethyl methanesulfonate in mouse lymphoma L5178Y cells. Mutagenesis. 2000;15:235-8 pubmed
    ..The latter would have a strong impact on risk assessment for mixtures at low doses...
  80. Chiu S, Evans H, Lam M, Nieminen A, Oleinick N. Phthalocyanine 4 photodynamic therapy-induced apoptosis of mouse L5178Y-R cells results from a delayed but extensive release of cytochrome c from mitochondria. Cancer Lett. 2001;165:51-8 pubmed
    ..Thus, in response to Pc 4-PDT, the release of cytochrome c from mitochondria is a key determinant of apoptotic cell death...
  81. Schmitt E, Metzler M, Jonas R, Dekant W, Stopper H. Genotoxic activity of four metabolites of the soy isoflavone daidzein. Mutat Res. 2003;542:43-8 pubmed
    ..2-fold induction at 100 microM) induced micronuclei in a concentration-dependent manner. Thus, both reductive and oxidative metabolites of the soy isoflavone daidzein exhibit genotoxic potential in vitro...
  82. Mitsui T, Miyake Y, Kakeya H, Osada H, Kataoka T. ECH, an epoxycyclohexenone derivative that specifically inhibits Fas ligand-dependent apoptosis in CTL-mediated cytotoxicity. J Immunol. 2004;172:3428-36 pubmed
    ..Therefore, ECH can be used as a bioprobe to evaluate the contributions of two distinct killing pathways in various CTL-target settings...
  83. Liu S, Cao J, Yuan J, Huang P, Shua P, Honma M. [Effects of total alkaloids of Tripterygium hypoglaucum Hutch on tk gene of mouse lymphoma cells]. Zhongguo Zhong Yao Za Zhi. 2003;28:954-7 pubmed
    ..To investigate the effects of total alkaloids of Tripterygium hypoglaucum Hutch (THH) on the tk gene of mouse lymphoma cells...
  84. Bringmann G, Lang G, Muhlbacher J, Schaumann K, Steffens S, Rytik P, et al. Sorbicillactone A: a structurally unprecedented bioactive novel-type alkaloid from a sponge-derived fungus. Prog Mol Subcell Biol. 2003;37:231-53 pubmed
    ..These properties qualify sorbicillactone A or one of its derivatives for animal and (hopefully) also future therapeutic human trials...
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    ..These and similar findings for other refined ARA-rich oils establish a strong body of evidence for the safety of this RAO...
  86. Lorge E. Comparison of different cytotoxicity measurements for the in vitro micronucleus assay using L5178Y and TK6 cells in support of OECD draft Test Guideline 487. Mutat Res. 2010;702:199-207 pubmed publisher
    ..Therefore, these parameters, recommended in the draft Test Guideline 487, are suitable to select the concentrations at the cytotoxicity required for genotoxicity assessment in the in vitro micronucleus assay without cytokinesis block...
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    ..Together with our previous report, these data suggest that rat DCs can use two mechanisms of cytotoxicity depending on their maturation/activation state...
  88. Aoki M, Furusawa Y, Higashi S, Watanabe M. Action spectra of apoptosis induction and reproductive cell death in L5178Y cells in the UV-B region. Photochem Photobiol Sci. 2004;3:268-72 pubmed
    ..These results suggest that although DNA damage induced by UV-B light can trigger apoptosis, or lead to reproductive cell death, other damage (membrane, protein and so on) may trigger those effects in the UV-A region...
  89. Singh S, Chen T, Chen L, Mei N, McLain E, Samokyszyn V, et al. Mutagenic effects of 4-hydroxynonenal triacetate, a chemically protected form of the lipid peroxidation product 4-hydroxynonenal, as assayed in L5178Y/Tk+/- mouse lymphoma cells. J Pharmacol Exp Ther. 2005;313:855-61 pubmed
  90. Kiskinis E, Suter W, Hartmann A. High throughput Comet assay using 96-well plates. Mutagenesis. 2002;17:37-43 pubmed
    ..By introducing the changes to our standard protocol, combined with automated image analysis, we were able to more than double our previous throughput...
  91. Shuai P, Zhang L, Wang Y. [Thymidine kinase gene mutation assay--comparison of microwell method and soft agar method]. Wei Sheng Yan Jiu. 2004;33:350-2 pubmed
    ..Two methods are used in TK locus mutation assay, i.e. microwell method and soft agar method. Two methods were compared in this study so that to find out the better one to be used in China...
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