leukemia l1210


Summary: An experimental LYMPHOCYTIC LEUKEMIA of mice.

Top Publications

  1. Cory A, Cory J. Lactacystin, a proteasome inhibitor, potentiates the apoptotic effect of parthenolide, an inhibitor of NFkappaB activation, on drug-resistant mouse leukemia L1210 cells. Anticancer Res. 2002;22:3805-9 pubmed
  2. Bilyy R, Stoika R. Lectinocytochemical detection of apoptotic murine leukemia L1210 cells. Cytometry A. 2003;56:89-95 pubmed
    ..We investigated whether specific changes in the expression of plasma membrane glycoproteins take place during apoptosis and whether these changes could be used for a quantitative estimation of apoptosis...
  3. Wang X, Wang P, Zhang K, Su X, Hou J, Liu Q. Initiation of autophagy and apoptosis by sonodynamic therapy in murine leukemia L1210 cells. Toxicol In Vitro. 2013;27:1247-59 pubmed publisher
    ..study was to examine autophagic and apoptotic responses to protoporphyrin IX (PpIX) mediated SDT in murine leukemia L1210 cells...
  4. Couture A, Deniau E, Grandclaudon P, Rybalko Rosen H, Leonce S, Pfeiffer B, et al. Synthesis and biological evaluation of aristolactams. Bioorg Med Chem Lett. 2002;12:3557-9 pubmed
    ..Modulations were carried out on the phenanthrene nucleus and the lactam moiety as well. N-(N-dialkylaminoalkyl) derivatives exhibited interesting cytotoxic activity against the L1210 leukemia cell line...
  5. Li H, Wang P, Liu Q, Cheng X, Zhou Y, Xiao Y. Cell cycle arrest and cell apoptosis induced by Equisetum hyemale extract in murine leukemia L1210 cells. J Ethnopharmacol. 2012;144:322-7 pubmed publisher
    ..The present study aimed to investigate the anti-proliferative effect and the underlying mechanisms of E.hyemale extract on murine leukemia L1210 cells.
  6. Kagi D, Vignaux F, Ledermann B, Burki K, Depraetere V, Nagata S, et al. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science. 1994;265:528-30 pubmed
    ..All cytotoxicity observed was due to either of these mechanisms, and no third mechanism was detected. Thus, the perforin- and Fas-based mechanisms may account for all T cell-mediated cytotoxicity in short-term in vitro assays...
  7. Waud W, Gilbert K, Secrist J. Lack of in vivo cross-resistance with 4'-thio-ara-C against drug-resistant murine P388 and L1210 leukemias. Cancer Chemother Pharmacol. 2011;68:399-403 pubmed publisher
  8. GÅ‚owacka I, Andrei G, Schols D, Snoeck R, Piotrowska D. Phosphonylated Acyclic Guanosine Analogues with the 1,2,3-Triazole Linker. Molecules. 2015;20:18789-807 pubmed publisher
    ..Compounds (1R,2S)-17k and (1S,2S)-17k showed the highest inhibitory effects (IC50=15-30 µM) against the proliferation of murine leukemia (L1210) and human T-lymphocyte (CEM) cell lines. ..
  9. Boger D, Searcey M, Tse W, Jin Q. Bifunctional alkylating agents derived from duocarmycin SA: potent antitumor activity with altered sequence selectivity. Bioorg Med Chem Lett. 2000;10:495-8 pubmed
    ..The series of four dimers derived from head to tail coupling of the two enantiomers of the duocarmycin SA alkylation subunit are described. ..

More Information

Publications114 found, 100 shown here

  1. Liu M, Luo M, Mozdziesz D, Lin T, Dutschman G, Gullen E, et al. Synthesis of halogen-substituted 3-deazaadenosine and 3-deazaguanosine analogues as potential antitumor/antiviral agents. Nucleosides Nucleotides Nucleic Acids. 2001;20:1975-2000 pubmed
    ..Several 3-deazaadenosine analogues (38, 51, 57 and 59) showed moderate to weak activity against hepatitis B virus. ..
  2. Ooi K. [The mechanism of synergistic interaction between etoposide and cytarabine]. Yakugaku Zasshi. 2002;122:471-80 pubmed
    ..We demonstrated that dCK activity was increased within 1 h after exposure to etoposide. Much more attention must be paid to the timing of the administration of etoposide in combination chemotherapy with etoposide and ara-C. ..
  3. Camoutsis C, Trafalis D, Pairas G, Papageorgiou A. On the formation of 4-[N,N-bis(2-chloroethyl)amino]phenyl acetic acid esters of hecogenin and aza-homo-hecogenin and their antileukemic activity. Farmaco. 2005;60:826-9 pubmed
    ..These results support that the alkylating esters of hecogenin produce important antitumor activity as well as, indicate that the aza-homo-hecogenin ester exhibits significantly higher activity due to lactam group (-NHCO-) modification. ..
  4. Lee H, Wondimu A, Liu Y, Ma J, Radoja S, Ladisch S. Ganglioside inhibition of CD8+ T cell cytotoxicity: interference with lytic granule trafficking and exocytosis. J Immunol. 2012;189:3521-7 pubmed
  5. Lee D, Jang P, Chung N, Cho B, Jeong D, Kim H. Deferasirox shows in vitro and in vivo antileukemic effects on murine leukemic cell lines regardless of iron status. Exp Hematol. 2013;41:539-46 pubmed publisher
    ..This study indicates an antileukemic effect of DFX regardless of iron status and suggests that the use of DFX has a survival benefit for SIO leukemia murine model in terms of iron chelation and antileukemic therapy. ..
  6. Lewin G, Hocquemiller R, Schaeffer C, Lambert P, Leonce S, Pierre A. Cytotoxicity of 6,16-disubstituted analogues of (-)-vincadifformine. Bioorg Med Chem Lett. 2002;12:371-4 pubmed
    ..None of the new compounds was more active than 1 but the modulation at C6, C16 and on the aromatic ring at C10 informs about structure-activity relationships within this series. ..
  7. Garnuszek P, Liciańska I, Skierski J, Koronkiewicz M, Mirowski M, Wiercioch R, et al. Biological investigation of the platinum(II)-[*I]iodohistamine complexes of potential synergistic anti-cancer activity. Nucl Med Biol. 2002;29:169-75 pubmed
    ..The results of the present study show promising features of the newly developed platinum-iodohistamine complexes and justify prospective investigation of in vivo anticancer potency on animal models of solid tumors. ..
  8. Drobna Z, Stein U, Walther W, Barancik M, Breier A. Pentoxifylline influences drug transport activity of P-glycoprotein and decreases mdrl gene expression in multidrug resistant mouse leukemic L1210/VCR cells. Gen Physiol Biophys. 2002;21:103-9 pubmed
    ..The levels of mdrl mRNA (measured by RT-PCR method) were decreased 2-fold in the presence of 100 mg/l PTX (minimum reached within 48 hours) in comparison to control cells. ..
  9. Quash G, Fournet G, Chantepie J, Gore J, Ardiet C, Ardail D, et al. Novel competitive irreversible inhibitors of aldehyde dehydrogenase (ALDH1): restoration of chemosensitivity of L1210 cells overexpressing ALDH1 and induction of apoptosis in BAF(3) cells overexpressing bcl(2). Biochem Pharmacol. 2002;64:1279-92 pubmed
    ..The methanethiol putatively released from DIMATE by ALDH1 esterase activity plays a role, albeit undefined, in lowering intramitochondrial glutathione levels which decreased by 47% as DNA-fragmentation increased. ..
  10. Bronder J, Moran R. Antifolates targeting purine synthesis allow entry of tumor cells into S phase regardless of p53 function. Cancer Res. 2002;62:5236-41 pubmed
    ..We conclude that carcinoma cells are killed equally well by DDATHF and related compounds whether or not the p53 pathway is intact and that the utility of GART inhibitors would not be limited to p53-negative tumors. ..
  11. Verma R, Hansch C. Elucidation of structure-activity relationships for 2- or 6-substituted-5,8-dimethoxy-1,4-naphthoquinones. Bioorg Med Chem. 2004;12:5997-6009 pubmed
    ..QSAR results have shown that these activities of 2- or 6-substituted-5,8-dimethoxy-1,4-naphthoquinones depend largely on their hydrophobicity. ..
  12. Cory A, Cory J. Understanding interactions between and among apoptosis inducing pathways in tumor cells. In Vivo. 2007;21:245-9 pubmed
  13. Lougiakis N, Marakos P, Pouli N, Poul N, Balzarini J. Synthesis and antiviral activity evaluation of some novel acyclic C-nucleosides. Chem Pharm Bull (Tokyo). 2008;56:775-80 pubmed
    ..The compounds were evaluated for their antiviral activity against a wide panel of viruses, but were found inactive at subtoxic concentrations. ..
  14. Namikoshi M, Akano K, Meguro S, Kasuga I, Mine Y, Takahashi T, et al. A new macrocyclic trichothecene, 12,13-deoxyroridin E, produced by the marine-derived fungus Myrothecium roridum collected in Palau. J Nat Prod. 2001;64:396-8 pubmed
    ..12,13-Deoxyroridin E is the second example of a macrocyclic trichothecene possessing a double bond at C-12-C-13 and was about 80-fold less cytotoxic than roridin E, the epoxide variant. ..
  15. Kim Y, Song R, Hyun Kim D, Jun M, Sohn Y. Synthesis, biodistribution and antitumor activity of hematoporphyrin-platinum(II) conjugates. Bioorg Med Chem. 2003;11:1753-60 pubmed
    ..The antitumor activity of the porphyrin-platinum(II) conjugates was assayed in vitro and in vivo against leukemia L1210 cell line and various human tumor cell lines...
  16. Liu Q, Lu Z, Wang X, Liu F. [The expression of mRNA and SDS-PAGE of L1210 cell strains and its cloned cells]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2003;34:207-9 pubmed
    ..Expression of c-myc, c-fos, p53 mRNA could distinguish L3E11 and L3F9 cloned cells. ..
  17. Esteban M, Rodriguez A, Ayala A, Meseguer J. Effects of high doses of cortisol on innate cellular immune response of seabream (Sparus aurata L.). Gen Comp Endocrinol. 2004;137:89-98 pubmed
    ..The present results demonstrate that cortisol plays an important role in the down-regulation of phagocytic but not of cytotoxic activity in seabream leucocytes. ..
  18. Graikou K, Aligiannis N, Skaltsounis A, Chinou I, Michel S, Tillequin F, et al. New diterpenes from Croton insularis. J Nat Prod. 2004;67:685-8 pubmed
    ..Their structures have been established by NMR and mass spectral data, and the absolute configuration of 1 and related trachylobane diterpenes was determined through a series of chemical correlations. ..
  19. Tomasi S, Lohezic Le Devehat F, Sauleau P, Bézivin C, Boustie J. Cytotoxic activity of methanol extracts from Basidiomycete mushrooms on murine cancer cell lines. Pharmazie. 2004;59:290-3 pubmed
    ..luteus). The last one had never been investigated for its cytotoxic compounds before. ..
  20. Docolomansky P, Fialová I, Barancik M, Rybár A, Breier A. Prolongation of pentoxifylline aliphatic side chain positively affects the reversal of P-glycoprotein-mediated multidrug resistance in L1210/VCR line cells. Gen Physiol Biophys. 2005;24:461-6 pubmed
    ..We found that both PTX-UHM and PTX were able to reverse vincristine resistance of L1210/VCR cells, yet PTX-UHM was significantly more efficient in the reversal than PTX. ..
  21. Bhatnagar P, Awasthi A, Nomellini J, Smit J, Suresh M. Anti-tumor effects of the bacterium Caulobacter crescentus in murine tumor models. Cancer Biol Ther. 2006;5:485-91 pubmed
    ..The results suggest that C. crescentus may be a safe, bacterial immunomodulator for the treatment of tumors. ..
  22. Lobert S, Fahy J, Hill B, Duflos A, Etievant C, Correia J. Vinca alkaloid-induced tubulin spiral formation correlates with cytotoxicity in the leukemic L1210 cell line. Biochemistry. 2000;39:12053-62 pubmed
    ..These studies are discussed in terms of the cellular mode of action of antimitotic drugs, particularly the importance of microtubule dynamics during mitosis and the factors that regulate those dynamics. ..
  23. Fiala R, Sulova Z, El Saggan A, Uhrik B, Liptaj T, Dovinova I, et al. P-glycoprotein-mediated multidrug resistance phenotype of L1210/VCR cells is associated with decreases of oligo- and/or polysaccharide contents. Biochim Biophys Acta. 2003;1639:213-24 pubmed
    ..All the above facts indicate that multidrug resistance of L1210/VCR cells mediated predominantly by drug efflux activity of Pgp is accompanied by a considerable depression of oligo- and/or polysaccharides biosynthesis. ..
  24. Hussein A, Mioglou Kalouptsi E, Papageorgiou A, Karapidaki I, Iakovidou Kritsi Z, Lialiaris T, et al. Comparison of new nitrosoureas esters with modified steroidal nucleus for cytogenetic and antineoplastic activity. In Vivo. 2007;21:389-95 pubmed
    ..w.; T/C: mean survival time of drug-treated animals (T) (excluding long term survivals) vs. corn-oil-treated controls (C)]. ..
  25. Bilyy R, Kit Y, Hellman U, Stoika R. AMID: new insights on its intracellular localization and expression at apoptosis. Apoptosis. 2008;13:729-32 pubmed publisher
    ..isolated by Pisum sativum lectin-affinity chromatography from the plasma membrane fraction of apoptotic murine leukemia L1210 cells, lacking in the intact cells...
  26. Cooper S, Gonzalez Hernandez M. Experimental reconsideration of the utility of serum starvation as a method for synchronizing mammalian cells. Cell Biol Int. 2009;33:71-7 pubmed publisher
  27. Wolfe A, Duncan K, Parelkar N, Brown D, Vielhauer G, Boger D. Efficacious cyclic N-acyl O-amino phenol duocarmycin prodrugs. J Med Chem. 2013;56:4104-15 pubmed publisher
    ..Clearly, the prodrug 6 benefits from either its controlled slow release of the free drug or its preferential intracellular reductive cleavage. ..
  28. Kiyomiya K, Matsuo S, Kurebe M. In situ photoaffinity labeling of proteasome with photoactive adriamycin analogue. Biochem Biophys Res Commun. 2000;273:928-32 pubmed
    ..These results suggest that the proteasome is a translocator of ADM from the cytoplasm to the nucleus and might therefore become a new candidate for cancer chemotherapy. ..
  29. Randazzo A, Bifulco G, Giannini C, Bucci M, Debitus C, Cirino G, et al. Halipeptins A and B: two novel potent anti-inflammatory cyclic depsipeptides from the Vanuatu marine sponge Haliclona species. J Am Chem Soc. 2001;123:10870-6 pubmed
    ..Halipeptin A was found to possess very potent anti-inflammatory activity in vivo, causing about 60% inhibition of edema in mice at the dose of 300 microg/kg (i.p.). ..
  30. Martin P, Rodier S, Mondon M, Renoux B, Pfeiffer B, Renard P, et al. Synthesis and cytotoxic activity of tetracenomycin D and of saintopin analogues. Bioorg Med Chem. 2002;10:253-60 pubmed
    ..Thus, tetracenomycin D and 3,8-di-O-methyl saintopin have been prepared in few steps. New derivatives of 10-deoxysaintopin have been also obtained. Evaluation of their cytotoxicity against L1210 leukemia cells are reported. ..
  31. Wang Y, Zhao R, Goldman I. Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line. Biochem Pharmacol. 2003;65:1163-70 pubmed
  32. Jantova S, Cipák L, Cernáková M, Kost álová D. Effect of berberine on proliferation, cell cycle and apoptosis in HeLa and L1210 cells. J Pharm Pharmacol. 2003;55:1143-9 pubmed
    ..protoberberine alkaloids against a variety of cancer cell lines were extended to human tumour HeLa and murine leukemia L1210 cell lines...
  33. Vashishtha S, Zello G, Nienaber K, Balzarini J, De Clercq E, Stables J, et al. Cytotoxic and anticonvulsant aryloxyaryl Mannich bases and related compounds. Eur J Med Chem. 2004;39:27-35 pubmed
    ..Anticonvulsant properties were demonstrated by a number of compounds in the maximal electroshock (MES) screen when administered intraperitoneally to mice while 4c and 6e afforded protection in the MES test when given orally to rats. ..
  34. Penning L, Piek C, Eib D, Schipper R, Holling T, Martens G. Induction of apoptosis in hematopoietic cells with an antibody against tomoregulin-1. Anticancer Res. 2006;26:339-46 pubmed
    ..Moreover, C29 increased [cAMP]i over 5-fold. Together, these data suggest that the C29 antiserum against tomoregulin-1 induces apoptosis of hematopoietic cells. ..
  35. de Mejia E, Wang W, Dia V. Lunasin, with an arginine-glycine-aspartic acid motif, causes apoptosis to L1210 leukemia cells by activation of caspase-3. Mol Nutr Food Res. 2010;54:406-14 pubmed publisher
    ..These results showed for the first time that lunasin, a naturally occurring peptide containing an RGD motif, caused apoptosis to L1210 leukemia cells through caspase-3 activation. ..
  36. Kameoka M, Ota K, Tetsuka T, Tanaka Y, Itaya A, Okamoto T, et al. Evidence for regulation of NF-kappaB by poly(ADP-ribose) polymerase. Biochem J. 2000;346 Pt 3:641-9 pubmed
    ..Taken together, these results strongly suggest that PARP is involved in the regulation of NF-kappaB through the protein modification. ..
  37. Kiyomiya K, Satoh J, Horie H, Kurebe M, Nakagawa H, Matsuo S. Correlation between nuclear action of anthracycline anticancer agents and their binding affinity to the proteasome. Int J Oncol. 2002;21:1081-5 pubmed
    ..These results suggest that the binding affinity of these anticancer agents to the proteasome is an important factor in their transport to the nucleus and determines their specificity of action for the nuclear DNA. ..
  38. Baraldi P, Beria I, Cozzi P, Bianchi N, Gambari R, Romagnoli R. Synthesis and growth inhibition activity of alpha-bromoacrylic heterocyclic and benzoheterocyclic derivatives of distamycin A modified on the amidino moiety. Bioorg Med Chem. 2003;11:965-75 pubmed
    ..on the distamycin frame, these derivatives showed significant growth inhibitory activity against mouse leukemia L1210 cells...
  39. Prachar J. Intimate contacts of mitochondria with nuclear envelope as a potential energy gateway for nucleo-cytoplasmic mRNA transport. Gen Physiol Biophys. 2003;22:525-34 pubmed
    ..Hence the lumen of the nuclear envelope can serve for transport or even storage of macroergic molecules in a manner similar to sarcoplasmic reticulum in fast-twitch skeletal muscles. ..
  40. Chung Y, Shin Y, Zhan C, Lee S, Cho H. Synthesis and evaluation of antitumor activity of 2- and 6-[(1,3-benzothiazol-2-yl)aminomethyl]-5,8-dimethoxy-1,4-naphthoquinone derivatives. Arch Pharm Res. 2004;27:893-900 pubmed
    ..The results suggests that a compound having higher E(HOMO) and deltaH values usually should have a lower ED50 (SNU-1) value. ..
  41. Cortesi R, Esposito E, Cuccu I, Romagnoli R, Menegatti E, Zaid A, et al. Liposomes and micellar dispersions for delivery of benzoheterocyclic derivatives of distamycin A. Drug Deliv. 2007;14:1-8 pubmed
    ..These effects were compared with those shown by the free drug depending on type of drug and also cell line used. ..
  42. Hu G, Wu X, Wang X, Zhang Z, Xie S, Huang W, et al. [Synthesis and antitumor activity of C3 heterocyclic-substituted fluoroquinolone derivatives (I): ciprofloxacin aminothiodiazole Schiff-bases]. Yao Xue Xue Bao. 2008;43:1112-5 pubmed
    ..Therefore, the C3 carboxyl group of fluoroquinolone is not necessary to antitumor activity. Functionally modified heterocycle-substituted fluoroquinolone as potent antitumor lead compound is valuable for further study. ..
  43. Gokhale P, Pei J, Zhang C, Ahmad I, Rahman A, Kasid U. Improved safety, pharmacokinetics and therapeutic efficacy profiles of a novel liposomal formulation of mitoxantrone. Anticancer Res. 2001;21:3313-21 pubmed
    ..A significant decrease in toxicity, altered pharmacokinetics, and enhanced efficacy of LEM suggest that LEM may provide a viable alternative to the clinical use of conventional mitoxantrone. ..
  44. Arsenou E, Fousteris M, Koutsourea A, Papageorgiou A, Karayianni V, Mioglou E, et al. The allylic 7-ketone at the steroidal skeleton is crucial for the antileukemic potency of chlorambucil's active metabolite steroidal esters. Anticancer Drugs. 2004;15:983-90 pubmed
  45. Verma R. Anti-cancer activities of 1,4-naphthoquinones: a QSAR study. Anticancer Agents Med Chem. 2006;6:489-99 pubmed
    ..QSAR results have shown that the cytotoxic activities of 1,4-naphthoquinones depend largely on their hydrophobicity. ..
  46. Ondrias K, Stasko A, Cacanyiova S, Sulova Z, Krizanova O, Kristek F, et al. H(2)S and HS(-) donor NaHS releases nitric oxide from nitrosothiols, metal nitrosyl complex, brain homogenate and murine L1210 leukaemia cells. Pflugers Arch. 2008;457:271-9 pubmed publisher
  47. Hu G, Hou L, Wang G, Duan N, Wen X, Cao T, et al. Part IV: Design, synthesis and antitumor activity of fluoroquinolone C-3 heterocycles: bis-oxadiazole methylsulfide derivatives derived from ciprofloxacin. Yao Xue Xue Bao. 2012;47:1017-22 pubmed
    ..The preliminary results show that piperazinium compounds (8) possess more potent activity than that of corresponding free bases (7). ..
  48. Huang X, Dai W, Darzynkiewicz Z. Enforced adhesion of hematopoietic cells to culture dish induces endomitosis and polyploidy. Cell Cycle. 2005;4:801-5 pubmed
    ..The phenomenon offers novel experimental model for induction of polyploidy and provides alternative to cytocholasin B to prevent cytokinesis in the mutagenicity cytokinesis-blocked micronucleus (CBMN) assay. ..
  49. Khalikova T, Korolenko T. [Effect of biological response modifier sulfoethylated (1 --> 3)-beta-D-glycan on the experimental leukemia in mice]. Eksp Klin Farmakol. 2006;69:39-43 pubmed
    ..The proposed treatment also led to an increase in the activity of lysosomal proteases (cathepsins B, L and D) in tumor tissues. The extent of changes was in direct relation to the therapeutic effect. ..
  50. Delgado M, Ganea D. Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit expression of Fas ligand in activated T lymphocytes by regulating c-Myc, NF-kappa B, NF-AT, and early growth factors 2/3. J Immunol. 2001;166:1028-40 pubmed
    ..VIP/PACAP inhibit the expression of Egr2 and 3, but not of Egr1. The effects on the transcriptional factors are mediated through type 2 VIP receptor with cAMP as secondary messenger...
  51. Cory A, Cory J. Phenolic compounds, sodium salicylate and related compounds, as inhibitors of tumor cell growth and inducers of apoptosis in mouse leukemia L1210 cells. In Vivo. 2005;19:31-5 pubmed
    ..These data suggest that salicylaldehyde and salicylaldoxime, the most active compounds in this series, may provide the lead chemicals from which other more active drugs can be synthesized...
  52. Rochais C, Dallemagne P, Rault S. Tripentones: a promising series of potent anti-cancer agents. Anticancer Agents Med Chem. 2009;9:369-80 pubmed
    ..This paper inventories the different synthetic strategies for tripentones and reviews their biological effects and therapeutic potential...
  53. Cunderlikova B, Vasovic V, Sieber F, Furre T, Nesland J, Peng Q. Hexaminolevulinate-mediated photodynamic purging of leukemia cells from BM. Bone Marrow Transplant. 2010;45:1553-61 pubmed publisher
    ..The efficacy of HAL-PDT in cell lines in vitro should be verified in clinically relevant in vivo models...
  54. Beggiolin G, Crippa L, Menta E, Manzotti C, Cavalletti E, Pezzoni G, et al. Bbr 2778, an aza-anthracenedione endowed with preclinical anticancer activity and lack of delayed cardiotoxicity. Tumori. 2001;87:407-16 pubmed
    ..In light of its spectrum of activity and marked efficacy against lymphomas and leukemias over a wide dose range, together with its lack of delayed cardiotoxicity, BBR 2778 has been entered in clinical studies...
  55. Maucourt K, Agarwal M, René B, Fermandjian S. Use of Chlamydomonas reinhardtii mutants for anticancer drug screening. Biochem Pharmacol. 2002;64:1125-31 pubmed
    ..reinhardtii could advantageously replace mammalian cells in the screening of the anticancer drugs. The alga enzymes could also provide an opportunity to delineate the phylogeny of the topoisomerase superfamily...
  56. Cedervall B, Edgren M, Lewensohn R. X-ray-induced DNA double-strand breaks in mouse l1210 cells: a new computational method for analyzing neutral filter elution data. Radiat Res. 2003;159:495-501 pubmed
    ..Mouse leukemia L1210 cells were X-irradiated with 0-50 Gy. Samples were then evaluated both with PFGE and with NFE...
  57. Rauko P, Bauer W, Horvath Z, Höchtl T, Saiko P, Karl D, et al. Combination effects of Ara-C and 5-fluorodeoxyuridine against leukemia cells in vitro and in mice. Anticancer Res. 2003;23:3841-6 pubmed
    ..Ara-C (1-beta-D-arabinofuranosylcytosine) is widely used for treatment of human leukemia. However, due to emergence of resistance, new drug combinations need to be developed...
  58. Karapidaki I, Bakopoulou A, Papageorgiou A, Iakovidou Z, Mioglou E, Nikolaropoulos S, et al. Genotoxic, cytostatic, antineoplastic and apoptotic effects of newly synthesized antitumour steroidal esters. Mutat Res. 2009;675:51-9 pubmed publisher
  59. Youssef D, Potter E, Jha M, De Clercq E, Balzarini J, Stables J, et al. Design, synthesis and bioevaluation of novel maleamic amino acid ester conjugates of 3,5-bisarylmethylene-4-piperidones as cytostatic agents. Bioorg Med Chem Lett. 2009;19:6364-7 pubmed publisher
    ..All compounds were found to have greater potency than the reference drug melphalan. Several compounds were found to potently inhibit topoisomerase IIalpha and displayed cytostatic activity in the nanomolar range...
  60. Yang L, Wang P, Cheng X, Zhang M, Xiao Y. [Suppressive effect of gypenosides on murine leukemia L1210 cell lines]. Zhong Yao Cai. 2010;33:1588-92 pubmed
    To investigate the suppressive effect of gypenosides (Gyp) on murine leukemia L1210 cells.
  61. Peasland A, Wang L, Rowling E, Kyle S, Chen T, Hopkins A, et al. Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines. Br J Cancer. 2011;105:372-81 pubmed publisher
    ..As NU6027, originally developed as a CDK2 inhibitor, potentiated cisplatin in a CDK2-independent manner we postulated that it may inhibit ATR...
  62. Monneret C, Risse S, Ardouin P, Gouyette A. Synthesis and antitumour activity of a new series of nitrosoureido sugars. Eur J Med Chem. 2000;35:137-46 pubmed
    ..Owing to its lower acute toxicity, methyl 3-[3-(2-chloroethyl)-3-nitrosoureido]-3, 4-dideoxy-beta-D-arabino-hexopyranoside 24 appeared as the best candidate for preclinical studies...
  63. Behrens C, Igney F, Arnold B, Moller P, Krammer P. CD95 ligand-expressing tumors are rejected in anti-tumor TCR transgenic perforin knockout mice. J Immunol. 2001;166:3240-7 pubmed
    ..Chemotaxis experiments revealed that CD95L has no direct neutrophil-attractive activity. Therefore, we conclude that LKC-CD95L cells used an indirect mechanism to attract neutrophils that may cause tumor rejection...
  64. Lisowski V, Enguehard C, Lancelot J, Caignard D, Lambel S, Leonce S, et al. Design, synthesis and antiproliferative activity of tripentones: a new series of antitubulin agents. Bioorg Med Chem Lett. 2001;11:2205-8 pubmed
    ..The most promising 3-(3-hydroxy-4-methoxyphenyl)thieno[2,3-b]pyrrolizin-8-one 20 (leukemia L1210, IC(50)=15 nM) was shown to be a potent inhibitor of tubulin polymerization.
  65. Bouget K, Aubin S, Delcros J, Arlot Bonnemains Y, Baudy Floc h M. Hydrazino-aza and N-azapeptoids with therapeutic potential as anticancer agents. Bioorg Med Chem. 2003;11:4881-9 pubmed
    ..These peptide analogues share a common backbone and bear different C- and N-terminal functions. Their antiproliferative activity on murine leukemia L1210 cells is reported here.
  66. Ishiguro K, Seow H, Penketh P, Shyam K, Sartorelli A. Mode of action of the chloroethylating and carbamoylating moieties of the prodrug cloretazine. Mol Cancer Ther. 2006;5:969-76 pubmed
  67. Ajjappala B, Kim Y, Kim M, Lee M, Lee K, Ki H, et al. 14-3-3 gamma is stimulated by IL-3 and promotes cell proliferation. J Immunol. 2009;182:1050-60 pubmed
    ..These results indicate that deregulated expression of 14-3-3gamma may contribute to malignant transformation, possibly providing a new target for therapeutic intervention in hematopoietic neoplasms...
  68. Gibalová L, Sereš M, Rusnák A, Ditte P, Labudova M, Uhrík B, et al. P-glycoprotein depresses cisplatin sensitivity in L1210 cells by inhibiting cisplatin-induced caspase-3 activation. Toxicol In Vitro. 2012;26:435-44 pubmed publisher
    ..All of the above findings indicate that P-gp, independent of its drug efflux activity, induced changes in cell regulatory pathways that confer a partial loss of cisplatin sensitivity...
  69. Li C, Wang C, Yang H, Zhao X, Wei N, Cui J. Liposomal topotecan formulation with a low polyethylene glycol grafting density: pharmacokinetics and antitumour activity. J Pharm Pharmacol. 2012;64:372-82 pubmed publisher
    ..In this study, a liposomal topotecan formulation with a low PEG grafting density was prepared and its pharmacokinetics, acute toxicity and antitumour effect were investigated...
  70. Finch R, Shyam K, Penketh P, Sartorelli A. 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-(methylamino)carbonylhydrazine (101M): a novel sulfonylhydrazine prodrug with broad-spectrum antineoplastic activity. Cancer Res. 2001;61:3033-8 pubmed
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    ..1 cells from AICD by diminishing FasL transcription through a pathway that is independent of the tyrosine phosphorylation of IRS1 and phosphatidylinositol 3'-kinase activity...
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    ..The cytotoxic concentrations of 4-amino-3-acetyl quinoline induced morphological changes of L1210 cells and the apoptotic DNA fragmentation...
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    ..Compared to the reported literature, the modification of methotrexate by poly (ethylene glycol) is more rapid and convenient...
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    ..In this study, the effects of nucleosides in the medium on the cytotoxicity and deoxyribonucleoside triphosphate pools after brief exposure of cultured cells to methotrexate have been studied in cultured L1210 murine leukaemia cells...
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    ..Therapeutic indices of CBM-11 were more favorable as compared to those received for ifosfamide...
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    A mouse leukemia L1210 cell line (Y8) selected for resistance to deoxyadenosine was found to be deficient in the expression of p53 mRNA and protein while maintaining the expression of WAF1/p21 mRNA and protein even under basal conditions...
  79. Searcey M. Duocarmycins--natures prodrugs?. Curr Pharm Des. 2002;8:1375-89 pubmed
    ..A simple analysis of the approaches that could be taken to vary the structure for targeting is suggested...
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    ..The results are discussed as to the possible relevance of the phenomenon in efficiency and regulation of the Tc cell response to infections by viruses...
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    ..Biological tests performed using leukemia L1210 cells have shown that toxicity of the title complex is similar to that of cisplatin.
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    ..localizes predominantly in the endoplasmic reticulum (ER) and, to a lesser extent, in mitochondria of murine leukemia L1210 cells. Subsequent irradiation results in the loss of ER > mitochondrial Bcl-2 and an apoptotic response...
  84. Cory A, Chen J, Cory J. Effects of PRIMA-1 on wild-type L1210 cells expressing mutant p53 and drug-resistant L1210 cells lacking expression of p53: necrosis vs. apoptosis. Anticancer Res. 2006;26:1289-95 pubmed
    The effects of PRIMA-1 on wild-type (WT) mouse leukemia L1210 cells and drug-resistant L1210 cells (Y8) were studied with respect to the induction of apoptosis and necrosis in these cell lines...
  85. Dimmock J, Padmanilayam M, Zello G, Nienaber K, Allen T, Santos C, et al. Cytotoxic analogues of 2,6-bis(arylidene)cyclohexanones. Eur J Med Chem. 2003;38:169-77 pubmed
    ..A number of lead molecules emerged from this investigation as well as guidelines for future expansion of these series of compounds...
  86. Duca M, Arimondo P, Leonce S, Pierre A, Pfeiffer B, Monneret C, et al. Novel carbamate derivatives of 4-beta-amino-4'-O-demethyl-4-desoxypodophyllotoxin as inhibitors of topoisomerase II: synthesis and biological evaluation. Org Biomol Chem. 2005;3:1074-80 pubmed
    ..Compounds 4a-c, 4g, 4j and 4k are topoisomerase II poisons that induce double-stranded breaks in DNA and exhibit increased cytotoxicity compared to etoposide...
  87. Pitie M, Croisy A, Carrez D, Boldron C, Meunier B. Cytostatic activity of 1,10-phenanthroline derivatives generated by the clip-phen strategy. Chembiochem. 2005;6:686-91 pubmed
    ..Attempts to vectorize 3-Clip-Phen derivatives with a DNA binder such as spermine or with a cell-penetration peptide failed to increase their biological activity relative to the original 3-Clip-Phen series...
  88. Milstein A, Kennedy M, Low P, Bouman C, Webb K. Statistical approach for detection and localization of a fluorescing mouse tumor in Intralipid. Appl Opt. 2005;44:2300-10 pubmed
    ..We validate the methods in an experimental study involving an excised mouse tumor tagged with a new folate-indocyanine dye and obscured under a tissue-simulating lipid suspension...
  89. Malvy C, Lefrancois M, Bertrand J, Markovits J. Modified alkaline elution allows the measurement of intact apurinic sites in mammalian genomic DNA. Biochimie. 2000;82:717-21 pubmed
    ..Using a modified alkaline elution method we show here that the stationary level of intact AP sites is about 0.16 per million of nucleotides in leukemic mouse L1210 cells...
  90. Kim J, Toti U, Song R, Sohn Y. A macromolecular prodrug of doxorubicin conjugated to a biodegradable cyclotriphosphazene bearing a tetrapeptide. Bioorg Med Chem Lett. 2005;15:3576-9 pubmed
    ..10 microM) but a reasonably higher in vitro cytotoxicity (IC50=1.1 microM) against the leukemia L1210 cell line probably due to its enzymatically controlled release.
  91. Okabe K, Hayashi M, Wakabayashi N, Yamawaki Y, Teranishi M, Fukushima N, et al. Different expressions and DNA methylation patterns of lysophosphatidic acid receptor genes in mouse tumor cells. Pathobiology. 2010;77:309-14 pubmed publisher
    ..In this study, we measured expression levels and DNA methylation status of LPA receptor genes in mouse tumor cells, LL/2 lung carcinoma, B16F0 melanoma, FM3A mammary carcinoma and L1210 leukemia cells, compared with normal tissues...
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    ..Fusion is obtained with cells of different origins with very different adhesion properties. Hybrid cells are easily formed. This approach appears to be a very efficient method for cell hybridization with an easy-to-use protocol...