bone marrow neoplasms

Summary

Summary: Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.

Top Publications

  1. Kollermann J, Weikert S, Schostak M, Kempkensteffen C, Kleinschmidt K, Rau T, et al. Prognostic significance of disseminated tumor cells in the bone marrow of prostate cancer patients treated with neoadjuvant hormone treatment. J Clin Oncol. 2008;26:4928-33 pubmed publisher
    ..To explore whether the presence of occult disseminated tumor cells (DTCs) in the bone marrow before neoadjuvant hormone therapy influences the prognosis of patients with organ confined prostate cancer treated by radical prostatectomy...
  2. Balic M, Lin H, Young L, Hawes D, Giuliano A, McNamara G, et al. Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype. Clin Cancer Res. 2006;12:5615-21 pubmed
    ..Recognizing the potential effect of prevalence of putative stem cells among DTC, we evaluated the bone marrow DTC...
  3. Slade M, Coombes R. The clinical significance of disseminated tumor cells in breast cancer. Nat Clin Pract Oncol. 2007;4:30-41 pubmed
  4. Fujita Y, Terashima M, Hoshino Y, Ohtani S, Kashimura S, Kanzaki N, et al. Detection of cancer cells disseminated in bone marrow using real-time quantitative RT-PCR of CEA, CK19, and CK20 mRNA in patients with gastric cancer. Gastric Cancer. 2006;9:308-14 pubmed
  5. Vincent Salomon A, Pierga J, Couturier J, d Enghien C, Nos C, Sigal Zafrani B, et al. HER2 status of bone marrow micrometastasis and their corresponding primary tumours in a pilot study of 27 cases: a possible tool for anti-HER2 therapy management?. Br J Cancer. 2007;96:654-9 pubmed
    ..Therefore, the efficiency of anti-HER2 adjuvant therapy could be evaluated, in a clinical trial, by sequential detection of HER2-positive micrometastatic cells within the bone marrow, before and after treatment...
  6. Kadikoylu G, Barutca S, Tataroglu C, Kafkas S, Erpek H, Meydan N, et al. Thrombotic thrombocytopenic purpura as the first manifestation of metastatic adenocarcinoma in a young woman. Transfus Apher Sci. 2010;42:39-42 pubmed publisher
    ..In conclusion, malignancy and bone marrow involvement should be considered when associated with leukoerythroblastic picture and TTP...
  7. Bozzi F, Collini P, Aiello A, Barzanò E, Gambirasio F, Podda M, et al. Flow cytometric phenotype of rhabdomyosarcoma bone marrow metastatic cells and its implication in differential diagnosis with neuroblastoma. Anticancer Res. 2008;28:1565-9 pubmed
    ..Myogenin (Myf4), a specific molecular RMS marker, was also investigated in the same samples. Since neuroblastoma (NB) metastasizes to the BM, the potential application of cytometry in differential diagnosis was explored...
  8. Becker S, Becker Pergola G, Banys M, Krawczyk N, Wallwiener D, Solomayer E, et al. Evaluation of a RT-PCR based routine screening tool for the detection of disseminated epithelial cells in the bone marrow of breast cancer patients. Breast Cancer Res Treat. 2009;117:227-33 pubmed publisher
    ..Immunocytochemistry (ICC) remains the gold standard for their detection. While assays based on RT-PCR are available, they have not been used for routine detection of DTC's...
  9. Barthel S, Wiese G, Cho J, Opperman M, Hays D, Siddiqui J, et al. Alpha 1,3 fucosyltransferases are master regulators of prostate cancer cell trafficking. Proc Natl Acad Sci U S A. 2009;106:19491-6 pubmed publisher
    ..These results indicate that alpha1,3 FTs could enhance metastatic efficiency of PCa by triggering an E-selectin-dependent trafficking mechanism...

More Information

Publications82

  1. Zhong X, Kaul S, Lin Y, Eichler A, Bastert G. Sensitive detection of micrometastases in bone marrow from patients with breast cancer using immunomagnetic isolation of tumor cells in combination with reverse transcriptase/polymerase chain reaction for cytokeratin-19. J Cancer Res Clin Oncol. 2000;126:212-8 pubmed
    ..For the early diagnosis of disseminating disease, this assay is more efficient than RT-PCR alone and routine immunocytochemistry...
  2. Benoy I, Salgado R, Elst H, Van Dam P, Weyler J, Van Marck E, et al. Relative microvessel area of the primary tumour, and not lymph node status, predicts the presence of bone marrow micrometastases detected by reverse transcriptase polymerase chain reaction in patients with clinically non-metastatic breast cancer. Breast Cancer Res. 2005;7:R210-9 pubmed
  3. Jauch K, Heiss M, Gruetzner U, Funke I, Pantel K, Babic R, et al. Prognostic significance of bone marrow micrometastases in patients with gastric cancer. J Clin Oncol. 1996;14:1810-7 pubmed
    ..The aim of this study was to examine the prognostic relevance of these cells in patients with gastric cancer and to evaluate by multivariate analysis their predictive value compared with conventional risk factors...
  4. Chim C, Ma E, Loong F, Kwong Y. Diagnostic cues for natural killer cell lymphoma: primary nodal presentation and the role of in situ hybridisation for Epstein-Barr virus encoded early small RNA in detecting occult bone marrow involvement. J Clin Pathol. 2005;58:443-5 pubmed
    ..This was resolved by in situ hybridisation for Epstein-Barr virus encoded small RNA, which detected occult bone marrow infiltration...
  5. Muller V, Stahmann N, Riethdorf S, Rau T, Zabel T, Goetz A, et al. Circulating tumor cells in breast cancer: correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity. Clin Cancer Res. 2005;11:3678-85 pubmed
  6. Schindlbeck C, Janni W, Shabani N, Kornmeier A, Rack B, Rjosk D, et al. Isolated tumor cells in the bone marrow (ITC-BM) of breast cancer patients before and after anthracyclin based therapy: influenced by the HER2- and Topoisomerase IIalpha-status of the primary tumor?. J Cancer Res Clin Oncol. 2005;131:539-46 pubmed
  7. Lim S, Tao M, Cheung Y, Rajan S, Mann B. Can patients with early-stage diffuse large B-cell lymphoma be treated without bone marrow biopsy?. Ann Oncol. 2005;16:215-8 pubmed
    ..Although BM biopsy is a safe procedure, it is often poorly tolerated. This analysis aims to assess the incidence of BM involvement and to identify parameters predicting BM involvement in early-stage DLBCL...
  8. Schindlbeck C, Janni W, Shabani N, Rack B, Gerber B, Schmitt M, et al. Comparative analysis between the HER2 status in primary breast cancer tissue and the detection of isolated tumor cells in the bone marrow. Breast Cancer Res Treat. 2004;87:65-74 pubmed
    ..The direct identification of HER2 on ITC-BM is the aim of ongoing research, potentially synergizing the prognostic relevance of ITC-BM and the predictive value of the HER2 status...
  9. Passlick B, Kubuschok B, Izbicki J, Thetter O, Pantel K. Isolated tumor cells in bone marrow predict reduced survival in node-negative non-small cell lung cancer. Ann Thorac Surg. 1999;68:2053-8 pubmed
    ..The clinical relevance of this minimal hematogenous tumor cell dissemination is under vigorous debate...
  10. Ozbas S, Dafydd H, Purushotham A. Bone marrow micrometastasis in breast cancer. Br J Surg. 2003;90:290-301 pubmed
    ..Several studies have demonstrated that bone marrow micrometastasis in patients with breast cancer is an independent prognostic factor for systemic recurrence and poorer survival...
  11. Moulopoulos L, Maris T, Papanikolaou N, Panagi G, Vlahos L, Dimopoulos M. Detection of malignant bone marrow involvement with dynamic contrast-enhanced magnetic resonance imaging. Ann Oncol. 2003;14:152-8 pubmed
    ..The purpose of this study was to evaluate the role of dynamic contrast-enhanced magnetic resonance imaging (dMRI) in detecting bone marrow involvement in cancer patients...
  12. Braun S, Hepp F, Kentenich C, Janni W, Pantel K, Riethmuller G, et al. Monoclonal antibody therapy with edrecolomab in breast cancer patients: monitoring of elimination of disseminated cytokeratin-positive tumor cells in bone marrow. Clin Cancer Res. 1999;5:3999-4004 pubmed
    ..Selection of EpCAM-/ CK+ tumor clones showed that further antibodies directed against tumor-associated antigens are warranted to improve the efficacy of monospecific approaches...
  13. Braun S, Pantel K. Clinical significance of occult metastatic cells in bone marrow of breast cancer patients. Oncologist. 2001;6:125-32 pubmed
    ..The present review summarizes the current data on the clinical significance of occult metastatic breast cancer cells in bone marrow...
  14. Woelfle U, Cloos J, Sauter G, Riethdorf L, Janicke F, van Diest P, et al. Molecular signature associated with bone marrow micrometastasis in human breast cancer. Cancer Res. 2003;63:5679-84 pubmed
    ..Thus, BM micrometastasis is a selective process with a specific molecular signature of the primary tumor...
  15. Funke I, Schraut W. Meta-analyses of studies on bone marrow micrometastases: an independent prognostic impact remains to be substantiated. J Clin Oncol. 1998;16:557-66 pubmed
    ..In the present meta-analyses, 20 studies, which included 2,494 patients, regarding the prognostic influence of a positive bone marrow micrometastases (BMM) status on relapse-free and/or overall survival were analyzed...
  16. Zhong X, Kaul S, Diel I, Eichler A, Bastert G. Analysis of sensitivity and specificity of cytokeratin 19 reverse transcriptase/polymerase chain reaction for detection of occult breast cancer in bone marrow and leukapheresis products. J Cancer Res Clin Oncol. 1999;125:286-91 pubmed
    ..The work aimed to evaluate the sensitivity and specificity of the cytokeratin (CK) 19 reverse transcriptase/polymerase chain reaction (RT-PCR) for the detection of occult breast cancer in bone marrow and leukapheresis products...
  17. Pantel K, Cote R, Fodstad O. Detection and clinical importance of micrometastatic disease. J Natl Cancer Inst. 1999;91:1113-24 pubmed
  18. Berois N, Varangot M, Aizen B, Estrugo R, Zarantonelli L, Fernandez P, et al. Molecular detection of cancer cells in bone marrow and peripheral blood of patients with operable breast cancer. Comparison of CK19, MUC1 and CEA using RT-PCR. Eur J Cancer. 2000;36:717-23 pubmed
    ..Our results suggest that CK19 and CEA RT-PCR assays are powerful methods for detecting disseminated breast cancer cells. A larger study with long-term follow-up is required in order to clarify their clinical usefulness...
  19. Bonavina L, Soligo D, Quirici N, Bossolasco P, Cesana B, Lembertenghi Deliliers G, et al. Bone marrow-disseminated tumor cells in patients with carcinoma of the esophagus or cardia. Surgery. 2001;129:15-22 pubmed
    ..In addition, we investigated the agreement between immunohistochemical and molecular techniques for the detection of micrometastases in a subgroup of patients...
  20. Braun S, Cevatli B, Assemi C, Janni W, Kentenich C, Schindlbeck C, et al. Comparative analysis of micrometastasis to the bone marrow and lymph nodes of node-negative breast cancer patients receiving no adjuvant therapy. J Clin Oncol. 2001;19:1468-75 pubmed
    ..In the present study we analyzed whether a correlation exists between microscopic tumor cell spread to bone marrow and to lymph nodes and attempted to determine which route is clinically more important...
  21. Braun S, Schlimok G, Heumos I, Schaller G, Riethdorf L, Riethmuller G, et al. ErbB2 overexpression on occult metastatic cells in bone marrow predicts poor clinical outcome of stage I-III breast cancer patients. Cancer Res. 2001;61:1890-5 pubmed
    ..78 (95% confidence interval, 1.11-6.96) for overall survival (P = 0.029). We therefore conclude that erbB2 overexpression characterizes a clinically relevant subset of breast cancer micrometastases...
  22. Flatmark K, Bjørnland K, Johannessen H, Hegstad E, Rosales R, Hårklau L, et al. Immunomagnetic detection of micrometastatic cells in bone marrow of colorectal cancer patients. Clin Cancer Res. 2002;8:444-9 pubmed
    ..Furthermore, that screening of 2 x 10(7) MNCs in a BM sample can be completed in <3 h makes the method an attractive alternative to other techniques...
  23. Jankowski K, Kucia M, Wysoczynski M, Reca R, Zhao D, Trzyna E, et al. Both hepatocyte growth factor (HGF) and stromal-derived factor-1 regulate the metastatic behavior of human rhabdomyosarcoma cells, but only HGF enhances their resistance to radiochemotherapy. Cancer Res. 2003;63:7926-35 pubmed
    ..Signaling from the c-MET receptor may also contribute to the resistance of RMS cells to conventional treatment modalities...
  24. Baur A, Bartl R, Pellengahr C, Baltin V, Reiser M. Neovascularization of bone marrow in patients with diffuse multiple myeloma: a correlative study of magnetic resonance imaging and histopathologic findings. Cancer. 2004;101:2599-604 pubmed
    ..The goal of the current study was to assess the correlation between bone marrow histology and contrast enhancement in infiltrative diffuse myeloma...
  25. Kaifi J, Yekebas E, Schurr P, Obonyo D, Wachowiak R, Busch P, et al. Tumor-cell homing to lymph nodes and bone marrow and CXCR4 expression in esophageal cancer. J Natl Cancer Inst. 2005;97:1840-7 pubmed
    ..We investigated CXCR4 expression in esophageal cancer specimens and its association with survival, lymph node microinvolvement, and bone marrow micrometastasis...
  26. Arkenau H, Müssig O, Buhr T, Jend H, Porschen R. Microangiopathic hemolytic anemia (MAHA) as paraneoplastic syndrome in metastasized signet ring cell carcinomas: case reports and review of the literature. Z Gastroenterol. 2005;43:719-22 pubmed
    ..Parallel to symptomatic treatment we started chemotherapy treatment (ELF and PLF regimen, respectively). In both cases we were able to control the MAHA and cancer progression...
  27. Braun S, Vogl F, Naume B, Janni W, Osborne M, Coombes R, et al. A pooled analysis of bone marrow micrometastasis in breast cancer. N Engl J Med. 2005;353:793-802 pubmed
    ..We assessed the prognostic significance of the presence of micrometastasis in the bone marrow at the time of diagnosis of breast cancer by means of a pooled analysis...
  28. Becker S, Becker Pergola G, Wallwiener D, Solomayer E, Fehm T. Detection of cytokeratin-positive cells in the bone marrow of breast cancer patients undergoing adjuvant therapy. Breast Cancer Res Treat. 2006;97:91-6 pubmed
    ..020). Adjuvant treatment regimens are not able to completely eliminate cytokeratin-positive cells from the bone marrow. Prospective studies need to evaluate, whether these cells could become targets for additional adjuvant therapy...
  29. Weihrauch M, Skibowski E, Koslowsky T, Voiss W, Re D, Kuhn Regnier F, et al. Immunomagnetic enrichment and detection of micrometastases in colorectal cancer: correlation with established clinical parameters. J Clin Oncol. 2002;20:4338-43 pubmed
    ..We used magnetic activated cell sorting (MACS), a highly sensitive method, to increase detection rates and correlated the presence of cytokeratin (CK)-expressing cells with clinical parameters...
  30. Slade M, Singh A, Smith B, Tripuraneni G, Hall E, Peckitt C, et al. Persistence of bone marrow micrometastases in patients receiving adjuvant therapy for breast cancer: results at 4 years. Int J Cancer. 2005;114:94-100 pubmed
    ..These results indicate that MRD persists despite adjuvant therapy in a majority of patients with primary breast cancer up to 4 years following surgery...
  31. Benoy I, Elst H, Van der Auwera I, Van Laere S, van Dam P, Van Marck E, et al. Real-time RT-PCR correlates with immunocytochemistry for the detection of disseminated epithelial cells in bone marrow aspirates of patients with breast cancer. Br J Cancer. 2004;91:1813-20 pubmed
  32. Benoy I, Elst H, Philips M, Wuyts H, Van Dam P, Scharpe S, et al. Prognostic significance of disseminated tumor cells as detected by quantitative real-time reverse-transcriptase polymerase chain reaction in patients with breast cancer. Clin Breast Cancer. 2006;7:146-52 pubmed
    ..Bone marrow samples from a large cohort of patients with breast cancer were analyzed for the presence of DTC by immunocytochemistry (ICC) or a molecular-based method...
  33. Benoy I, Elst H, Philips M, Wuyts H, van Dam P, Scharpe S, et al. Real-time RT-PCR detection of disseminated tumour cells in bone marrow has superior prognostic significance in comparison with circulating tumour cells in patients with breast cancer. Br J Cancer. 2006;94:672-80 pubmed
    ..The use of either larger volumes of PB or performing an enrichment step for circulating tumour in blood cells might improve these results...
  34. Gray R, O Donnell M, Verghis R, McCluggage W, Maxwell P, McGuigan J, et al. Bone marrow micrometastases in esophageal carcinoma: a 10-year follow-up study. Dis Esophagus. 2012;25:709-15 pubmed publisher
    ..Although the presence of BMMs correlates with recognized adverse tumor characteristics in patients with esophageal cancer, micrometastases detected in the bone marrow at time of surgery does not influence long-term survival. ..
  35. Guan J, Wang X, Ma K. [One-step method of bone marrow aspiration and biopsy applied in diagnosis of the bone marrow metastatic cancer]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2013;21:1054-7 pubmed publisher
    ..The bone marrow biopsy is better than that of aspiration in diagnosis of metastatic cancer. Combining biopsy with aspiration can improve the accuracy of diagnosis. ..
  36. Tsuji K, Doyama H, Yamada S, Kaneko Y, Takemura K, Tsuji S, et al. [A case of disseminated carcinomatosis of bone marrow treated by S-1 and cisplatin after distal gastrectomy for early gastric cancer]. Gan To Kagaku Ryoho. 2012;39:813-5 pubmed
    ..After one course of treatment, DIC was resolved and his pain was relieved. He survived for about nine months. S-1 and cisplatin are considered to be effective for disseminated carcinosis of bone marrow. ..
  37. Nowicka J, Nahaczewska W, Owczarek H, Woźniak M. The decrease in prolidase activity in myeloproliferative neoplasms. Adv Clin Exp Med. 2012;21:767-71 pubmed
  38. Torigian D, Lopez R, Alapati S, Bodapati G, Hofheinz F, van den Hoff J, et al. Feasibility and performance of novel software to quantify metabolically active volumes and 3D partial volume corrected SUV and metabolic volumetric products of spinal bone marrow metastases on 18F-FDG-PET/CT. Hell J Nucl Med. 2011;14:8-14 pubmed
    ..This novel approach has great potential for practical, accurate, and precise combined structural-functional PET quantification of disease before and after therapeutic intervention. ..
  39. Chantada G, Sampor C, Bosaleh A, Solernou V, Fandino A, de Davila M. Comparison of staging systems for extraocular retinoblastoma: analysis of 533 patients. JAMA Ophthalmol. 2013;131:1127-34 pubmed publisher
    ..For lower stages, only the IRSS considers all unequivocal pathological prognostic factors. For higher stages, all systems had redundant information, resulting in an excess of substages. ..
  40. Sinha P, Okoro C, Foell D, Freeze H, Ostrand Rosenberg S, Srikrishna G. Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cells. J Immunol. 2008;181:4666-75 pubmed
    ..Since S100A8/A9 activation of MDSC is through the NF-kappaB signaling pathway, drugs that target this pathway may reduce MDSC levels and be useful therapeutic agents in conjunction with active immunotherapy in cancer patients. ..
  41. Hong J, Lee Y, Park Y, Kim S, Hwang K, Park S, et al. Role of FDG-PET/CT in detecting lymphomatous bone marrow involvement in patients with newly diagnosed diffuse large B-cell lymphoma. Ann Hematol. 2012;91:687-695 pubmed publisher
    ..The results suggest that FDG-PET/CT had a limited value to detect BM involvement in patients with DLBCL. Focal hypermetabolism of hematopoietic BM in FDG-PET/CT had no impact on survival. ..
  42. Gozdziuk K, Kedra M, Rybojad P, Sagan D. A rare case of solitary plasmacytoma mimicking a primary lung tumor. Ann Thorac Surg. 2009;87:e25-6 pubmed publisher
    ..We present a 31-year-old patient who was diagnosed with a solitary plasmacytoma located in the lung mimicking a primary lung tumor. After several weeks, this developed into multiple myeloma. ..
  43. Zhao S, Xing Y, Natkunam Y. Use of CD137 ligand expression in the detection of small B-cell lymphomas involving the bone marrow. Hum Pathol. 2014;45:1024-30 pubmed publisher
  44. Walther A, Cost N, Garrison A, Geller J, Alam S, Tiao G. Renal rhabdomyosarcoma in a pancake kidney. Urology. 2013;82:458-60 pubmed publisher
    ..Treatment included multimodal therapy, consisting of neoadjuvant chemotherapy, complete surgical resection, and adjuvant chemotherapy. He remains in clinical remission 7 months after resection. ..
  45. Lesnik J, ANTES T, Kim J, Griner E, Pedro L. Registered report: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. elife. 2016;5:e07383 pubmed publisher
    ..2012). The Reproducibility Project: Cancer Biology is a collaboration between the Center for Open Science and Science Exchange and the results of the replications will be published in eLife. ..
  46. Gore S. New ways to use DNA methyltransferase inhibitors for the treatment of myelodysplastic syndrome. Hematology Am Soc Hematol Educ Program. 2011;2011:550-5 pubmed publisher
    ..New information on the impact of DNMT inhibitors on the immune system and on stem cells will likely lead to novel uses of these drugs in MDS and other hematologic and nonhematologic malignancies. ..
  47. Isozaki Y, Yamanishi M, Utsunomiya S, Yamaguchi S, Okita M, Matsumoto N, et al. [A case of disseminated carcinomatosis of bone marrow with disseminated intravascular coagulation caused by advanced colon cancer treated by mFOLFOX6]. Gan To Kagaku Ryoho. 2011;38:1705-8 pubmed
    ..He was treated with the systemic chemotherapy of modified FOLFOX6 (mFOLFOX6). After one course of the treatment, DIC was resolved and severe back pain and lumbargo were improved. ..
  48. Kim D, Royal A, Villamil J. Disseminated melanoma in a dog with involvement of leptomeninges and bone marrow. Vet Pathol. 2009;46:80-3 pubmed publisher
    ..This case report describes a unique presentation of canine melanoma, which in some ways resembles leptomeningeal melanomatosis, a rare human melanoma variant. ..
  49. Arush M, Kollender Y, Issakov J, Shalom R, Arieh Y, Malkin L, et al. Unusual leptomeningeal dissemination in a child with extracranial metastatic alveolar rhabdomyosarcoma. Pediatr Hematol Oncol. 2009;26:473-8 pubmed publisher
  50. Buergy D, Fuchs T, Kambakamba P, Mudduluru G, Maurer G, Post S, et al. Prognostic impact of extracellular matrix metalloprotease inducer: immunohistochemical analyses of colorectal tumors and immunocytochemical screening of disseminated tumor cells in bone marrow from patients with gastrointestinal cancer. Cancer. 2009;115:4667-78 pubmed publisher
  51. Marconato L, Bonfanti U, Stefanello D, Lorenzo M, Romanelli G, Comazzi S, et al. Cytosine arabinoside in addition to VCAA-based protocols for the treatment of canine lymphoma with bone marrow involvement: does it make the difference?. Vet Comp Oncol. 2008;6:80-9 pubmed publisher
    ..Ara-C added to a VCAA-based protocol appears to be safe and beneficial in dogs with stage V lymphoma. Incorporation of the nucleoside analogue might be crucial for the development of future therapeutic strategies in dogs. ..
  52. Satoh D, Ninomiya M, Umeoka T, Harano M, Sasaki H, Aoki H, et al. [A case of progressive gastric carcinoma accompanied by disseminated carcinomatosis of bone marrow due to bone metastasis with DIC recovery by joint administration of 5-FU and paclitaxel]. Gan To Kagaku Ryoho. 2006;33:2079-81 pubmed
    ..5-FU+PTX therapy is considered to be effective for DIC due to bone metastasis of gastric carcinoma...
  53. Mansi J, Morden J, Bliss J, Neville M, Coombes R. Bone marrow micrometastases in early breast cancer-30-year outcome. Br J Cancer. 2016;114:243-7 pubmed publisher
    ..In multivariable analyses, the presence of micrometastases was no longer a statistically significant prognostic factor. Bone marrow micrometastases are predictive for OS, particularly in the first decade and in younger patients. ..
  54. Janku F, Srovnal J, Korinkova G, Novotny J, Petruzelka L, Power D, et al. Molecular detection of disseminated breast cancer cells in the bone marrow of early breast cancer patients using quantitative RT PCR for CEA. Neoplasma. 2008;55:317-22 pubmed
    ..Clinical and prognostic relevance of minimal residual disease using this technique remains unproven. Our results should be interpreted with caution with regard to 2 deaths in CEA positive group with no relationship to disease recurrence...
  55. Wang H, Yan H, Liu J, Duan L, Wang Z, Zhu L, et al. Haploidentical hematopoietic stem-cell transplantation for non-Hodgkin lymphoma with bone marrow involvement. Leuk Lymphoma. 2009;50:1488-93 pubmed
    ..71 months (range: 44-81 months). The results here suggest that haplo-HSCT might provide an opportunity of myeloablative therapy for refractory lymphoma with marrow infiltration...
  56. Berg A, Berner A, Lilleby W, Bruland Ø, Fossa S, Nesland J, et al. Impact of disseminated tumor cells in bone marrow at diagnosis in patients with nonmetastatic prostate cancer treated by definitive radiotherapy. Int J Cancer. 2007;120:1603-9 pubmed
    ..In conclusion our study shows that presence of DTCs in BM at diagnosis was associated with the histological differentiation of the primary tumor and an increased risk of developing distant metastases after RT...
  57. Inoue K, Okada K, Harigae H, Taki Y, Goto R, Kinomura S, et al. Diffuse bone marrow uptake on F-18 FDG PET in patients with myelodysplastic syndromes. Clin Nucl Med. 2006;31:721-3 pubmed
    ..These cases demonstrate that diffuse FDG uptake by bone marrow can suggest neoplastic disease of the hematopoietic tissues...
  58. Chisholm J, Machin D, McDowell H, McHugh K, Ellershaw C, Jenney M, et al. Efficacy of carboplatin given in a phase II window study to children and adolescents with newly diagnosed metastatic soft tissue sarcoma. Eur J Cancer. 2007;43:2537-44 pubmed
    ..The activity of carboplatin was evaluated in a phase II window study in previously untreated children with metastatic soft tissue sarcoma...
  59. Morita K, Nakamine H, Inoue R, Takano M, Takeda M, Enomoto Y, et al. Autopsy case of primary myelofibrosis in which myeloid sarcoma was the initial manifestation of tumor progression. Pathol Int. 2012;62:433-7 pubmed publisher
    ..Therefore, it is important to recognize that there is a wide variation in the pathogeneses of MyS and PMF...
  60. Ozkan M, Er O, Karahan I, Deniz K, Coskun R, Kucuk C, et al. Rectal carcinoid tumor with bone marrow and osteoblastic bone metastasis: a case report. Turk J Gastroenterol. 2007;18:111-4 pubmed
    ..Bone marrow involvement might be a poor prognostic factor in carcinoid tumor as has been the case in many other tumors...
  61. Mancosu P, Navarria P, Castagna L, Roggio A, Pellegrini C, Reggiori G, et al. Anatomy driven optimization strategy for total marrow irradiation with a volumetric modulated arc therapy technique. J Appl Clin Med Phys. 2012;13:3653 pubmed publisher
    ..A clinical protocol started in our department in October 2010. ..
  62. Qian L, Zhang Z, Shen J, Liu Y. Primary bone marrow B-cell non-Hodgkin's lymphoma successfully treated with R-CHOP. West Indian Med J. 2013;62:89-91 pubmed
    ..We concluded that primary bone marrow mature small B-cell lymphoma is a rare but distinctive subtype of lymphoma. The prognosis for this entity is poor but rituximab-based treatment is promising for improving its outcomes...
  63. Messiou C, Collins D, Morgan V, Desouza N. Optimising diffusion weighted MRI for imaging metastatic and myeloma bone disease and assessing reproducibility. Eur Radiol. 2011;21:1713-8 pubmed publisher
    ..To establish normal bone marrow values of apparent diffusion coefficient (ADC) over an age range, compare them with metastatic and myelomatous involvement, to establish reproducibility and to optimise b values...
  64. Bruland Ø, Høifødt H, Hall K, Smeland S, Fodstad Ø. Bone marrow micrometastases studied by an immunomagnetic isolation procedure in extremity localized non-metastatic osteosarcoma patients. Cancer Treat Res. 2009;152:509-15 pubmed publisher
  65. Ohsugi T, Wakamiya M, Morikawa S, Matsuura K, Kumar J, Kumasaka T, et al. Invasion of histiocytic sarcoma into the spinal cord of HTLV-1 tax transgenic mice with HTLV-1-associated myelopathy/tropical spastic paraparesis-like disease. Oncol Res. 2013;20:403-10 pubmed publisher
  66. Demeulenaere M, Duerinck J, DU Four S, Fostier K, Michotte A, Neyns B. Bone Marrow Metastases from a 1p/19q Co-deleted Oligodendroglioma - A Case Report. Anticancer Res. 2016;36:4145-9 pubmed
    ..Despite best supportive care, the patient died three weeks after diagnosis of myelophthisis. Extracranial metastases from CNS oligodendroglioma are a very rare event but can be the cause of bone marrow failure. ..
  67. Guo S, Bai H, Megyola C, Halene S, Krause D, Scadden D, et al. Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms. Proc Natl Acad Sci U S A. 2012;109:16636-41 pubmed publisher
    ..Our data demonstrate that miR-125a-induced MPN is addicted to its sustained overexpression, and highlight the complex nature of oncogenic miRNA dependence in an early neoplastic state...
  68. Kushner B, Modak S, Kramer K, Basu E, Roberts S, Cheung N. Ifosfamide, carboplatin, and etoposide for neuroblastoma: a high-dose salvage regimen and review of the literature. Cancer. 2013;119:665-71 pubmed publisher
    ..A major reason for using this regimen was the long time since patients received previous treatment with a platinum compound. The authors also summarized the published experience on ICE in patients with NB...
  69. Edry Botzer L, Maman S, Sagi Assif O, Meshel T, Nevo I, Bauerle T, et al. Lung-residing metastatic and dormant neuroblastoma cells. Am J Pathol. 2011;179:524-36 pubmed publisher
    ..We hypothesize that the DisNB cells are metastasis precursors, which may progress toward metastasis under certain microenvironmental conditions...
  70. Rauh M, Al Habeeb A, Chang H. Microangiopathic hemolytic anemia and leukoerythroblastic blood film heralding bone marrow metastatic gastroesophageal adenocarcinoma. Pathol Res Pract. 2011;207:121-3 pubmed publisher
  71. Turial S, Karabul N, Gutjahr P, Engel V, Bierschock S, Schier F. Ovarian tumours: late extramedullary recurrence of acute leukaemia. Eur J Pediatr Surg. 2009;19:184-6 pubmed publisher
    ..Isolated extramedullary relapse, especially ovarian recurrence, of acute leukaemia is rare. Local therapy such as irradiation or extensive surgical resection of the mass is ineffective and unnecessary...
  72. Iguchi H, Matsuhisa T. [Characteristic features of bone disease in disseminated carcinomatosis of bone marrow]. Nihon Rinsho. 2007;65 Suppl 9:550-4 pubmed
  73. Gupta G, Robertson P, Szer J. Focal lesions on magnetic resonance imaging in aplastic anaemia: multiple metastases or haemopoietic marrow. Australas Radiol. 2007;51 Spec No.:B110-4 pubmed
    ..In this case, the low signal intensity lesions represent regenerating, expanding haemopoietic marrow...