oropharyngeal neoplasms

Summary

Summary: Tumors or cancer of the OROPHARYNX.

Top Publications

  1. D Souza G, Agrawal Y, Halpern J, Bodison S, Gillison M. Oral sexual behaviors associated with prevalent oral human papillomavirus infection. J Infect Dis. 2009;199:1263-9 pubmed publisher
    ..046, for trend) or open-mouthed kissing partners (P = .023, for trend) but not vaginal sex partners. Oral sex and open-mouthed kissing are associated with the development of oral HPV infection...
  2. Chung C, Schwartz D. Impact of HPV-related head and neck cancer in clinical trials: opportunity to translate scientific insight into personalized care. Otolaryngol Clin North Am. 2012;45:795-806 pubmed publisher
    ..This review discusses these research issues...
  3. Semrau R, Duerbaum H, Temming S, Huebbers C, Stenner M, Drebber U, et al. Prognostic impact of human papillomavirus status, survivin, and epidermal growth factor receptor expression on survival in patients treated with radiochemotherapy for very advanced nonresectable oropharyngeal cancer. Head Neck. 2013;35:1339-44 pubmed publisher
    ..The influence of human papillomavirus (HPV) status on survival for patients with very advanced inoperable oropharyngeal SCC treated with radiochemotherapy (RCT) was studied...
  4. Gao G, Chernock R, Gay H, Thorstad W, Zhang T, Wang H, et al. A novel RT-PCR method for quantification of human papillomavirus transcripts in archived tissues and its application in oropharyngeal cancer prognosis. Int J Cancer. 2013;132:882-90 pubmed publisher
    ..Thus, p16 mRNA or protein expression signature is a sensitive and specific surrogate marker for HPV transcriptional activity (all genotypes combined)...
  5. Marklund L, Näsman A, Ramqvist T, Dalianis T, Munck Wikland E, Hammarstedt L. Prevalence of human papillomavirus and survival in oropharyngeal cancer other than tonsil or base of tongue cancer. Cancer Med. 2012;1:82-8 pubmed publisher
    ..Our data highlight the diversity of head neck cancer sub-sites and the importance of taking OSCC sub-sites in consideration in future clinical trials and treatment...
  6. Holzinger D, Flechtenmacher C, Henfling N, Kaden I, Grabe N, Lahrmann B, et al. Identification of oropharyngeal squamous cell carcinomas with active HPV16 involvement by immunohistochemical analysis of the retinoblastoma protein pathway. Int J Cancer. 2013;133:1389-99 pubmed publisher
  7. Anantharaman D, Gheit T, Waterboer T, Abedi Ardekani B, Carreira C, McKay Chopin S, et al. Human papillomavirus infections and upper aero-digestive tract cancers: the ARCAGE study. J Natl Cancer Inst. 2013;105:536-45 pubmed publisher
    ..Human papillomavirus (HPV) is causally implicated in a subset of cancers of the upper aero-digestive tract (UADT)...
  8. JORDAN R, Lingen M, Perez Ordonez B, He X, Pickard R, Koluder M, et al. Validation of methods for oropharyngeal cancer HPV status determination in US cooperative group trials. Am J Surg Pathol. 2012;36:945-54 pubmed publisher
    ..A new validated H-score for p16 IHC assessment is proposed. Appropriate assay choice depends on clinical implications of a false-positive or false-negative test...
  9. Näsman A, Nordfors C, Grün N, Munck Wikland E, Ramqvist T, Marklund L, et al. Absent/weak CD44 intensity and positive human papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma indicates a very high survival. Cancer Med. 2013;2:507-18 pubmed publisher

More Information

Publications87

  1. Halec G, Holzinger D, Schmitt M, Flechtenmacher C, Dyckhoff G, Lloveras B, et al. Biological evidence for a causal role of HPV16 in a small fraction of laryngeal squamous cell carcinoma. Br J Cancer. 2013;109:172-83 pubmed publisher
    ..Human papillomavirus (HPV) is a causal factor in virtually all cervical and a subset of oropharyngeal squamous cell carcinoma (OP-SCC), whereas its role in laryngeal squamous cell carcinoma (L-SCC) is unclear...
  2. Schache A, Liloglou T, Risk J, Jones T, Ma X, Wang H, et al. Validation of a novel diagnostic standard in HPV-positive oropharyngeal squamous cell carcinoma. Br J Cancer. 2013;108:1332-9 pubmed publisher
    ..Recently, a novel RNA in situ hybridisation test (RNAscope) has been developed for the detection of HR-HPV in FFPE tissue; however, validation against the 'gold standard' has not been reported...
  3. Lewis J. p16 Immunohistochemistry as a standalone test for risk stratification in oropharyngeal squamous cell carcinoma. Head Neck Pathol. 2012;6 Suppl 1:S75-82 pubmed publisher
  4. Huang H, Zhang B, Chen W, Zou S, Zhang Y, Qiao Y. [Detection of human papillomavirus in oropharyngeal squamous cell carcinoma]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2012;34:545-9 pubmed publisher
    ..To investigate the infection rate and subtypes of human papilloma virus(HPV) in patients with oropharyngeal squamous cell carcinoma (OSCC) and analyze the clinicopathologic features of patients with or without HPV infection...
  5. Kato H, Yui T, Yamamoto N, Okada T, Urano M, Sakurai K, et al. [The clinical significance of thymidylate synthase expression in human papillomavirus-related oropharyngeal squamous carcinoma]. Nihon Jibiinkoka Gakkai Kaiho. 2012;115:957-64 pubmed
    ..Our studies suggested that positive HPV status was most strongly associated with a favorable prognosis in the patients with OSCC. TS expression has an unusual aspect as a biomarker for OSCC, though it was not related to prognosis...
  6. de Freitas Cordeiro Silva M, Stur E, Agostini L, de Podestá J, De Oliveira J, Soares M, et al. Promoter hypermethylation in primary squamous cell carcinoma of the oral cavity and oropharynx: a study of a Brazilian cohort. Mol Biol Rep. 2012;39:10111-9 pubmed publisher
    ..In contrast, CDKN2A and RUNX3 genes could be considered differentially methylated genes and potential tumor markers in OSCCs...
  7. Paolini F, Rizzo C, Sperduti I, Pichi B, Mafera B, Rahimi S, et al. Both mucosal and cutaneous papillomaviruses are in the oral cavity but only alpha genus seems to be associated with cancer. J Clin Virol. 2013;56:72-6 pubmed publisher
    ..The majority of published studies on HPV prevalence in these tumors concentrated on identifying high-risk mucosal types...
  8. Holzinger D, Schmitt M, Dyckhoff G, Benner A, Pawlita M, Bosch F. Viral RNA patterns and high viral load reliably define oropharynx carcinomas with active HPV16 involvement. Cancer Res. 2012;72:4993-5003 pubmed publisher
    ..55, 95% CI, 0.29-1.08). In summary, our findings argued that viral load or RNA pattern analysis is better suited than p16(INK4a) expression to identify HPV16-driven tumors in OPSCC patient populations...
  9. Liang C, Marsit C, McClean M, Nelson H, Christensen B, Haddad R, et al. Biomarkers of HPV in head and neck squamous cell carcinoma. Cancer Res. 2012;72:5004-13 pubmed publisher
  10. Brown L, Check D, Devesa S. Oropharyngeal cancer incidence trends: diminishing racial disparities. Cancer Causes Control. 2011;22:753-63 pubmed publisher
    ..The OCPC decreases found among all the race/sex groups reflect reductions in smoking prevalence and alcohol consumption. Rising HPV-related cancers among white men may reflect changes in sexual practices since the mid-1960s. ..
  11. Shi W, Kato H, Perez Ordonez B, Pintilie M, Huang S, Hui A, et al. Comparative prognostic value of HPV16 E6 mRNA compared with in situ hybridization for human oropharyngeal squamous carcinoma. J Clin Oncol. 2009;27:6213-21 pubmed publisher
    ..However, the latter two assays are technically easier to perform; hence, HPV16 ISH or p16 IHC should become standard evaluations for all patients with OSCC. ..
  12. Suwinski R, Jaworska M, Nikiel B, Grzegorz W, Bankowska Wozniak M, Wojciech M, et al. Predicting the effect of accelerated fractionation in postoperative radiotherapy for head and neck cancer based on molecular marker profiles: data from a randomized clinical trial. Int J Radiat Oncol Biol Phys. 2010;77:438-46 pubmed publisher
    ..Combining individual predictors in a joint score may improve their predictive potential. ..
  13. Tachezy R, Klozar J, Rubenstein L, Smith E, Salakova M, Smahelova J, et al. Demographic and risk factors in patients with head and neck tumors. J Med Virol. 2009;81:878-87 pubmed publisher
  14. Park W, Ryu J, Cho K, Choi M, Moon S, Yun T, et al. Human papillomavirus in oropharyngeal squamous cell carcinomas in Korea: use of G1 cycle markers as new prognosticators. Head Neck. 2012;34:1408-17 pubmed publisher
    ..S.-European data. HPV presence correlates with improved survival. Expression ratios of G1 markers may predict survival of oropharyngeal SCCs better than each marker alone. ..
  15. Perisanidis C, Perisanidis B, Wrba F, Brandstetter A, El Gazzar S, Papadogeorgakis N, et al. Evaluation of immunohistochemical expression of p53, p21, p27, cyclin D1, and Ki67 in oral and oropharyngeal squamous cell carcinoma. J Oral Pathol Med. 2012;41:40-6 pubmed publisher
    ..Our results suggest that the biomarkers p53, p21, p27, cyclin D1, and Ki67 have no impact on treatment response and survival in patients with oral and oropharyngeal cancer treated with preoperative chemoradiation. ..
  16. Hong A, Grulich A, Jones D, Lee C, Garland S, Dobbins T, et al. Squamous cell carcinoma of the oropharynx in Australian males induced by human papillomavirus vaccine targets. Vaccine. 2010;28:3269-72 pubmed publisher
    ..56 cases of oropharyngeal cancer per 100,000 males per year were associated with HPV types targeted by the vaccine. Vaccinating males may substantially reduce the burden of oropharyngeal cancer in Australia. ..
  17. Setton J, Caria N, Romanyshyn J, Koutcher L, Wolden S, Zelefsky M, et al. Intensity-modulated radiotherapy in the treatment of oropharyngeal cancer: an update of the Memorial Sloan-Kettering Cancer Center experience. Int J Radiat Oncol Biol Phys. 2012;82:291-8 pubmed publisher
    ..Our results confirm the feasibility of IMRT in achieving excellent locoregional control and low rates of xerostomia. According to our knowledge, this study is the largest report of patients treated with IMRT for OPC. ..
  18. Braakhuis B, Visser O, Leemans C. Oral and oropharyngeal cancer in The Netherlands between 1989 and 2006: Increasing incidence, but not in young adults. Oral Oncol. 2009;45:e85-9 pubmed publisher
    ..The reason for the decreasing annual incidence rate at all sites observed for Dutch young adults remains to be explained. ..
  19. Tomita N, Kodaira T, Furutani K, Tachibana H, Hasegawa Y, Terada A, et al. Long-term follow-up and a detailed prognostic analysis of patients with oropharyngeal cancer treated with radiotherapy. J Cancer Res Clin Oncol. 2010;136:617-23 pubmed publisher
    ..Primary radiotherapy was recommended for OPC patients with the lateral wall at the primary site because of good LRC. The treatment method to the older population and T4 tumor is future tasks. ..
  20. Cohan D, Popat S, Kaplan S, Rigual N, Loree T, Hicks W. Oropharyngeal cancer: current understanding and management. Curr Opin Otolaryngol Head Neck Surg. 2009;17:88-94 pubmed
    ..For the time being, we propose using local subsite and disease stage to guide therapeutic decision-making. ..
  21. Ribeiro K, Levi J, Pawlita M, Koifman S, Matos E, Eluf Neto J, et al. Low human papillomavirus prevalence in head and neck cancer: results from two large case-control studies in high-incidence regions. Int J Epidemiol. 2011;40:489-502 pubmed publisher
    ..The proportion of head and neck cancer caused by HPV may vary substantially between different geographical regions and studies that are designed to evaluate the impact of HPV vaccination on HNSCC need to consider this heterogeneity. ..
  22. McGovern S, Williams M, Weber R, Sabichi A, Chambers M, Martin J, et al. Three synchronous HPV-associated squamous cell carcinomas of Waldeyer's ring: case report and comparison with Slaughter's model of field cancerization. Head Neck. 2010;32:1118-24 pubmed publisher
    ..Therefore, the emerging population of young patients with head and neck SCC with HPV-positive cancers presents a new opportunity for understanding the molecular origins of synchronous tumors. ..
  23. Sharma A, Mohanti B, Thakar A, Bahadur S, Bhasker S. Concomitant chemoradiation versus radical radiotherapy in advanced squamous cell carcinoma of oropharynx and nasopharynx using weekly cisplatin: a phase II randomized trial. Ann Oncol. 2010;21:2272-7 pubmed publisher
    ..CRT and CR were independent prognostic factors. This trial on Indian head and neck squamous cell carcinoma patients confirms that the use of weekly cisplatin is safe and CRT is superior to RT alone resulting in higher OS. ..
  24. Klussmann J, Preuss S, Speel E. [Human papillomavirus and cancer of the oropharynx. Molecular interaction and clinical implications]. HNO. 2009;57:113-22 pubmed publisher
    ..Therefore, we think it will be mandatory to consider and stratify HPV status in the design of prospective clinical trials in the future. ..
  25. Quon H, Cohen M, Montone K, Ziober A, Wang L, Weinstein G, et al. Transoral robotic surgery and adjuvant therapy for oropharyngeal carcinomas and the influence of p16 INK4a on treatment outcomes. Laryngoscope. 2013;123:635-40 pubmed publisher
    ..446, P = .277, P = .643, respectively). p16(INK4a) was not prognostic in resectable OPSCC when treated with an initial TORS approach. ..
  26. Ohnishi K, Shioyama Y, Nakamura K, Nakashima T, Ohga S, Nonoshita T, et al. Concurrent chemoradiotherapy with S-1 as first-line treatment for patients with oropharyngeal cancer. J Radiat Res. 2011;52:47-53 pubmed
    ..The treatment-related toxicities were acceptable, and the incidence of myelotoxicity was low. Further study must be carried out to compare with other chemotherapy regimens. ..
  27. Posner M, Lorch J, Goloubeva O, Tan M, Schumaker L, Sarlis N, et al. Survival and human papillomavirus in oropharynx cancer in TAX 324: a subset analysis from an international phase III trial. Ann Oncol. 2011;22:1071-7 pubmed publisher
    ..These results support the possibility of selectively reducing therapy and long-term morbidity in HPV+ OPC while preserving survival and approaching HPV- disease with more aggressive treatment. ..
  28. Leonhardt F, Quon H, Abrahão M, O Malley B, Weinstein G. Transoral robotic surgery for oropharyngeal carcinoma and its impact on patient-reported quality of life and function. Head Neck. 2012;34:146-54 pubmed publisher
    ..Combination TORS and adjuvant therapy caused a temporary decrease in several domains at 6 months, returning to baseline including swallowing function in all patients. ..
  29. Ramqvist T, Dalianis T. An epidemic of oropharyngeal squamous cell carcinoma (OSCC) due to human papillomavirus (HPV) infection and aspects of treatment and prevention. Anticancer Res. 2011;31:1515-9 pubmed
    ..Finally, we suggest that the possibility to vaccinate against HPV-positive OSCC should be examined. ..
  30. Iseli T, Kulbersh B, Iseli C, Carroll W, Rosenthal E, Magnuson J. Functional outcomes after transoral robotic surgery for head and neck cancer. Otolaryngol Head Neck Surg. 2009;141:166-71 pubmed publisher
    ..Patients with advanced T stage, laryngeal or oropharyngeal site, and preoperative enterogastric feeding may be at increased risk of enterogastric feeding and poor swallowing outcomes. ..
  31. Sinha P, Lewis J, Piccirillo J, Kallogjeri D, Haughey B. Extracapsular spread and adjuvant therapy in human papillomavirus-related, p16-positive oropharyngeal carcinoma. Cancer. 2012;118:3519-30 pubmed publisher
    ..The authors propose that de-escalated adjuvant therapy should be considered for patients with p16-positive OPSCC who undergo surgery and that routinely reported ECS should not be used to justify adjuvant chemotherapy. ..
  32. Agoston E, Robinson S, Mehra K, Birch C, Semmel D, Mirkovic J, et al. Polymerase chain reaction detection of HPV in squamous carcinoma of the oropharynx. Am J Clin Pathol. 2010;134:36-41 pubmed publisher
    ..However, it is imperative that appropriate sensitivity controls be in place for such assays...
  33. Hocking J, Stein A, Conway E, Regan D, Grulich A, Law M, et al. Head and neck cancer in Australia between 1982 and 2005 show increasing incidence of potentially HPV-associated oropharyngeal cancers. Br J Cancer. 2011;104:886-91 pubmed publisher
    ..69% (95% CI: -1.96, -1.42%)), but not in females. Potentially HPV-associated oropharyngeal cancer in Australia is increasing; the impact of HPV vaccination on these cancers should be monitored. ..
  34. Chaturvedi A, Madeleine M, Biggar R, Engels E. Risk of human papillomavirus-associated cancers among persons with AIDS. J Natl Cancer Inst. 2009;101:1120-30 pubmed publisher
  35. Nichols A, Faquin W, Westra W, Mroz E, Begum S, Clark J, et al. HPV-16 infection predicts treatment outcome in oropharyngeal squamous cell carcinoma. Otolaryngol Head Neck Surg. 2009;140:228-34 pubmed publisher
    ..To determine if patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) treated with chemoradiation have improved outcomes...
  36. Eisbruch A, Harris J, Garden A, Chao C, Straube W, Harari P, et al. Multi-institutional trial of accelerated hypofractionated intensity-modulated radiation therapy for early-stage oropharyngeal cancer (RTOG 00-22). Int J Radiat Oncol Biol Phys. 2010;76:1333-8 pubmed publisher
    ..To assess the results of a multi-institutional study of intensity-modulated radiation therapy (IMRT) for early oropharyngeal cancer...
  37. Lewis J, Thorstad W, Chernock R, Haughey B, Yip J, Zhang Q, et al. p16 positive oropharyngeal squamous cell carcinoma:an entity with a favorable prognosis regardless of tumor HPV status. Am J Surg Pathol. 2010;34:1088-96 pubmed publisher
    ..Many recommend use of both p16 immunohistochemistry and HPV in situ hybridization (ISH). A significant minority of tumors are p16 positive and HPV ISH negative, the significance of which is unclear...
  38. Feng F, Kim H, Lyden T, Haxer M, Worden F, Feng M, et al. Intensity-modulated chemoradiotherapy aiming to reduce dysphagia in patients with oropharyngeal cancer: clinical and functional results. J Clin Oncol. 2010;28:2732-8 pubmed publisher
    ..To assess clinical and functional results of chemoradiotherapy for oropharyngeal cancer (OPC), utilizing intensity-modulated radiotherapy (IMRT) to spare the important swallowing structures to reduce post-therapy dysphagia...
  39. Rich J, Milov S, Lewis J, Thorstad W, Adkins D, Haughey B. Transoral laser microsurgery (TLM) +/- adjuvant therapy for advanced stage oropharyngeal cancer: outcomes and prognostic factors. Laryngoscope. 2009;119:1709-19 pubmed publisher
    ..Document survival, prognostic variables, and functional outcomes of patients with AJCC stage III or IV oropharyngeal cancer, treated with transoral laser microsurgery (TLM) +/- adjuvant therapy...
  40. Biron V, Cote D, Seikaly H. Oropharyngeal squamous cell carcinoma and human papillomavirus-associated cancers in women: epidemiologic evaluation of association. J Otolaryngol Head Neck Surg. 2011;40 Suppl 1:S65-9 pubmed
    ..Human papillomavirus (HPV) is a well-established etiologic factor in oropharyngeal squamous cell carcinoma (OPSCC). The objective of this study was to evaluate the association between OPSCC and HPV-related cancerous lesions of the cervix...
  41. de Souza D, de Camargo Cancela M, Pérez M, Curado M. Trends in the incidence of oral cavity and oropharyngeal cancers in Spain. Head Neck. 2012;34:649-54 pubmed publisher
    ..The purpose of this study was to analyze and compare incidence trends of oral cavity and oropharyngeal cancers, using data from population-based Spanish cancer registries...
  42. Sturgis E, Ang K. The epidemic of HPV-associated oropharyngeal cancer is here: is it time to change our treatment paradigms?. J Natl Compr Canc Netw. 2011;9:665-73 pubmed
    ..However, data are currently insufficient to change treatment paradigms for HPV-associated oropharyngeal cancer outside of a closely monitored clinical trial...
  43. Laco J, Nekvindova J, Novakova V, Celakovsky P, Dolezalova H, Tucek L, et al. Biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral and oropharyngeal squamous cell carcinoma, with emphasis on smoking, protein p16(INK4a) expression, and HPV status. Neoplasma. 2012;59:398-408 pubmed publisher
    ..Smoking itself does not seem to be an important prognostic factor...
  44. Atula T, Hunter K, Cooper L, Shoaib T, Ross G, Soutar D. Micrometastases and isolated tumour cells in sentinel lymph nodes in oral and oropharyngeal squamous cell carcinoma. Eur J Surg Oncol. 2009;35:532-8 pubmed publisher
    ..We compared the UICC/TNM definitions of MMs and ITCs with our previously published sentinel node protocol to assess how the adoption of the UICC/TNM criteria would affect the staging of nodal micrometastatic disease...
  45. Kreimer A, Villa A, Nyitray A, Abrahamsen M, Papenfuss M, Smith D, et al. The epidemiology of oral HPV infection among a multinational sample of healthy men. Cancer Epidemiol Biomarkers Prev. 2011;20:172-82 pubmed publisher
    ..40%, respectively). It remains unclear whether this reflects reduced exposure or if the oral region is more resistant to HPV infection compared with anogenital sites. ..
  46. Kreimer A, Bhatia R, Messeguer A, Gonzalez P, Herrero R, Giuliano A. Oral human papillomavirus in healthy individuals: a systematic review of the literature. Sex Transm Dis. 2010;37:386-91 pubmed publisher
    ..HPV16 DNA detected in oral specimens has recently been identified as a risk factor for some oropharyngeal cancers. The reported prevalence of oral HPV infection from individual studies is highly variable...
  47. Warnakulasuriya S. Causes of oral cancer--an appraisal of controversies. Br Dent J. 2009;207:471-5 pubmed publisher
    ..Some controversies related to the aetiology of this disease also need clarification. The objective of this paper is to provide an opinion on these debated controversies...
  48. Schache A, Liloglou T, Risk J, Filia A, Jones T, Sheard J, et al. Evaluation of human papilloma virus diagnostic testing in oropharyngeal squamous cell carcinoma: sensitivity, specificity, and prognostic discrimination. Clin Cancer Res. 2011;17:6262-71 pubmed publisher
    ..In clinical trials, HPV16 status is an essential inclusion or stratification parameter, highlighting the importance of accurate testing...
  49. Fischer C, Zlobec I, Green E, Probst S, Storck C, Lugli A, et al. Is the improved prognosis of p16 positive oropharyngeal squamous cell carcinoma dependent of the treatment modality?. Int J Cancer. 2010;126:1256-62 pubmed publisher
    ..The improved prognosis of p16 positive OPSCC is found after RT as well as after surgery...
  50. Maxwell J, Kumar B, Feng F, Worden F, Lee J, Eisbruch A, et al. Tobacco use in human papillomavirus-positive advanced oropharynx cancer patients related to increased risk of distant metastases and tumor recurrence. Clin Cancer Res. 2010;16:1226-35 pubmed publisher
  51. Gillison M, Zhang Q, Jordan R, Xiao W, Westra W, Trotti A, et al. Tobacco smoking and increased risk of death and progression for patients with p16-positive and p16-negative oropharyngeal cancer. J Clin Oncol. 2012;30:2102-11 pubmed publisher
    ..Tobacco smoking is associated with oropharynx cancer survival, but to what extent cancer progression or death increases with increasing tobacco exposure is unknown...
  52. Saba N, Edelman S, Tighiouart M, Gaultney J, Davis L, Khuri F, et al. Concurrent chemotherapy with intensity-modulated radiation therapy for locally advanced squamous cell carcinoma of the larynx and oropharynx: a retrospective single-institution analysis. Head Neck. 2009;31:1447-55 pubmed publisher
    ..We present outcome data from concurrent chemotherapy and intensity-modulated radiation therapy (IMRT) for squamous cell carcinoma (SCC) of the larynx and oropharyx...
  53. Rampias T, Sasaki C, Weinberger P, Psyrri A. E6 and e7 gene silencing and transformed phenotype of human papillomavirus 16-positive oropharyngeal cancer cells. J Natl Cancer Inst. 2009;101:412-23 pubmed publisher
    ..We examined the effects of repressing E6 and E7 oncogene expression on the transformed phenotype of HPV16-positive oropharyngeal cancer cell lines...
  54. Lohavanichbutr P, Houck J, Fan W, Yueh B, Mendez E, Futran N, et al. Genomewide gene expression profiles of HPV-positive and HPV-negative oropharyngeal cancer: potential implications for treatment choices. Arch Otolaryngol Head Neck Surg. 2009;135:180-8 pubmed publisher
    ..To study the difference in gene expression between human papillomavirus (HPV)-positive and HPV-negative oral cavity and oropharyngeal squamous cell carcinoma (OSCC)...
  55. Fukada J, Shigematsu N, Takeda A, Ohashi T, Tomita T, Shiotani A, et al. Weekly low-dose docetaxel-based chemoradiotherapy for locally advanced oropharyngeal or hypopharyngeal carcinoma: a retrospective, single-institution study. Int J Radiat Oncol Biol Phys. 2010;76:417-24 pubmed publisher
    ..To retrospectively assess the efficacy, toxicity, and prognostic factors of weekly low-dose docetaxel-based chemoradiotherapy for Stage III/IV oropharyngeal or hypopharyngeal carcinoma...
  56. Sinclair C, McColloch N, Carroll W, Rosenthal E, Desmond R, Magnuson J. Patient-perceived and objective functional outcomes following transoral robotic surgery for early oropharyngeal carcinoma. Arch Otolaryngol Head Neck Surg. 2011;137:1112-6 pubmed publisher
    ..To evaluate changes in patient-perceived swallowing function over time following transoral robotic surgery (TORS) for primary T1 and T2 oropharyngeal squamous cell carcinomas...
  57. Junor E, Kerr G, Oniscu A, Campbell S, Kouzeli I, Gourley C, et al. Benefit of chemotherapy as part of treatment for HPV DNA-positive but p16-negative squamous cell carcinoma of the oropharynx. Br J Cancer. 2012;106:358-65 pubmed publisher
    ..To determine (a) the cause of an improvement in survival from oropharyngeal squamous cell carcinoma (OSCC) in South East Scotland and (b) whether this improvement was human papillomavirus (HPV) and p16 subtype-dependent...
  58. El Naggar A, Westra W. p16 expression as a surrogate marker for HPV-related oropharyngeal carcinoma: a guide for interpretative relevance and consistency. Head Neck. 2012;34:459-61 pubmed publisher
    ..This perspective addresses the conceptual and practical issues associated with the p16 expression analysis and provides a broad outline for its application and evaluation in patients with oropharyngeal carcinoma...
  59. Moore E, Olsen K, Kasperbauer J. Transoral robotic surgery for oropharyngeal squamous cell carcinoma: a prospective study of feasibility and functional outcomes. Laryngoscope. 2009;119:2156-64 pubmed publisher
    ..To investigate the feasibility of transoral robotic surgery as a method of surgical treatment of oropharyngeal squamous cell carcinoma...
  60. Klussmann J, Mooren J, Lehnen M, Claessen S, Stenner M, Huebbers C, et al. Genetic signatures of HPV-related and unrelated oropharyngeal carcinoma and their prognostic implications. Clin Cancer Res. 2009;15:1779-86 pubmed publisher
    ..Patients with human papillomavirus (HPV)-containing oropharyngeal squamous cell carcinomas (OSCC) have a better prognosis than patients with HPV-negative OSCC. This may be attributed to different genetic pathways promoting cancer...
  61. Robinson M, Sloan P, Shaw R. Refining the diagnosis of oropharyngeal squamous cell carcinoma using human papillomavirus testing. Oral Oncol. 2010;46:492-6 pubmed publisher
    ..Furthermore, the techniques employed are automated and are subject to stringent quality assurance measures; features that can deliver routine, accurate and cost effective HPV testing for oropharyngeal cancers...
  62. Kreeft A, van der Molen L, Hilgers F, Balm A. Speech and swallowing after surgical treatment of advanced oral and oropharyngeal carcinoma: a systematic review of the literature. Eur Arch Otorhinolaryngol. 2009;266:1687-1698 pubmed publisher
  63. Schiefke F, Akdemir M, Weber A, Akdemir D, Singer S, Frerich B. Function, postoperative morbidity, and quality of life after cervical sentinel node biopsy and after selective neck dissection. Head Neck. 2009;31:503-12 pubmed publisher
    ..It is claimed that SNB may be superior to selective neck dissection (SND) with respect to quality of life (QOL) and postoperative morbidity...
  64. Ang K, Sturgis E. Human papillomavirus as a marker of the natural history and response to therapy of head and neck squamous cell carcinoma. Semin Radiat Oncol. 2012;22:128-42 pubmed publisher
  65. de Camargo Cancela M, de Souza D, Curado M. International incidence of oropharyngeal cancer: a population-based study. Oral Oncol. 2012;48:484-90 pubmed publisher
    ..2) and females (13.5). The results provide an overview of oropharyngeal cancer incidence and constitute a basis for the development of primary and secondary prevention, according to geographical variations and topography...
  66. Dziegielewski P, O Connell D, Rieger J, Harris J, Seikaly H. The lip-splitting mandibulotomy: aesthetic and functional outcomes. Oral Oncol. 2010;46:612-7 pubmed publisher
    ..05). The LSMA provides satisfactory scarring and low self-perception of disfigurement for patients. Moreover, the LSMA does not impact lower-lip sensation, movement or oral continence...
  67. Blomberg M, Nielsen A, Munk C, Kjaer S. Trends in head and neck cancer incidence in Denmark, 1978-2007: focus on human papillomavirus associated sites. Int J Cancer. 2011;129:733-41 pubmed publisher
    ..HPV16 is the type most often found in HNCs; thus, the recent introduction of vaccination against HPV may in the future prevent HPV-associated cancers of the head and neck...
  68. Heusinkveld M, Goedemans R, Briet R, Gelderblom H, Nortier J, Gorter A, et al. Systemic and local human papillomavirus 16-specific T-cell immunity in patients with head and neck cancer. Int J Cancer. 2012;131:E74-85 pubmed publisher
    ..The local presence of HPV16-specific T-cell immunity in HPV16-induced HNSCC implicates a role in the antitumor response and support the development of immunotherapy for HNSCC...
  69. Mehta V, Yu G, Schantz S. Population-based analysis of oral and oropharyngeal carcinoma: changing trends of histopathologic differentiation, survival and patient demographics. Laryngoscope. 2010;120:2203-12 pubmed publisher
    ..To test the hypothesis that decreased histologic differentiation and increased disease-specific survival is related to a decline in smoking rates and an increased percentage of human papillomavirus (HPV)-related tumors...
  70. Guan X, Sturgis E, Lei D, Liu Z, Dahlstrom K, Wei Q, et al. Association of TGF-beta1 genetic variants with HPV16-positive oropharyngeal cancer. Clin Cancer Res. 2010;16:1416-22 pubmed publisher
  71. Auluck A, Hislop G, Bajdik C, Poh C, Zhang L, Rosin M. Trends in oropharyngeal and oral cavity cancer incidence of human papillomavirus (HPV)-related and HPV-unrelated sites in a multicultural population: the British Columbia experience. Cancer. 2010;116:2635-44 pubmed publisher
    ..Little is known about the ethnic variation in incidence for these cancers. This study determined incidence rates of OCC and oropharyngeal cancer among South Asian, Chinese, and the general population in British Columbia, Canada...
  72. Albinger Hegyi A, Stoeckli S, Schmid S, Storz M, Iotzova G, Probst Hensch N, et al. Lysyl oxidase expression is an independent marker of prognosis and a predictor of lymph node metastasis in oral and oropharyngeal squamous cell carcinoma (OSCC). Int J Cancer. 2010;126:2653-62 pubmed publisher
    ..Moreover, LOX overexpression may be an early phenomenon in the pathogenesis of OSCC and thus an attractive novel target for chemopreventive and therapeutic strategies...
  73. Chaturvedi A, Engels E, Pfeiffer R, Hernandez B, Xiao W, Kim E, et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol. 2011;29:4294-301 pubmed publisher
    ..Recent increases in incidence and survival of oropharyngeal cancers in the United States have been attributed to human papillomavirus (HPV) infection, but empirical evidence is lacking...
  74. Gupta D, Shukla P, Bisht S, Dhawan A, Pant M, Bhatt M, et al. A prospective comparision of sequential chemoradiation vs concurrent chemoradiation in locally advanced oropharyngeal carcinomas. Cancer Biol Ther. 2009;8:213-7 pubmed
    ..The beneficial role of chemoradiation following induction chemotherapy over concurrent chemoradiation has not been evaluated. Present study evaluates the same prospectively...
  75. Clemente S, Wu B, Sanguineti G, Fusco V, Ricchetti F, Wong J, et al. SmartArc-based volumetric modulated arc therapy for oropharyngeal cancer: a dosimetric comparison with both intensity-modulated radiation therapy and helical tomotherapy. Int J Radiat Oncol Biol Phys. 2011;80:1248-55 pubmed publisher
    ..To investigate the roles of volumetric modulated arc therapy with SmartArc (VMAT-S), intensity-modulated radiation therapy (IMRT), and helical tomotherapy (HT) for oropharyngeal cancer using a simultaneous integrated boost (SIB) approach...
  76. Hong A, Dobbins T, Lee C, Jones D, Harnett G, Armstrong B, et al. Human papillomavirus predicts outcome in oropharyngeal cancer in patients treated primarily with surgery or radiation therapy. Br J Cancer. 2010;103:1510-7 pubmed publisher
    ..This study examines the prognostic significance of human papillomavirus (HPV) in patients with locally advanced oropharyngeal squamous cell carcinoma (SCC) treated primarily with surgery or definitive radiotherapy...
  77. Ramqvist T, Dalianis T. Oropharyngeal cancer epidemic and human papillomavirus. Emerg Infect Dis. 2010;16:1671-7 pubmed publisher
    ..We also suggest that individualized treatment modalities and preventive vaccination should be further explored...
  78. Daly M, Le Q, Maxim P, Loo B, Kaplan M, Fischbein N, et al. Intensity-modulated radiotherapy in the treatment of oropharyngeal cancer: clinical outcomes and patterns of failure. Int J Radiat Oncol Biol Phys. 2010;76:1339-46 pubmed publisher
    ..To report outcomes, failures, and toxicities in patients treated with intensity-modulated radiotherapy (IMRT) for squamous cell carcinoma of the oropharynx...