leydig cell tumor

Summary

Summary: Gonadal interstitial or stromal cell neoplasm composed of only LEYDIG CELLS. These tumors may produce one or more of the steroid hormones such as ANDROGENS; ESTROGENS; and CORTICOSTEROIDS. Clinical symptoms include testicular swelling, GYNECOMASTIA, sexual precocity in children, or virilization (VIRILISM) in females.

Top Publications

  1. Peters M, Teerds K, van der Gaag I, de Rooij D, van Sluijs F. Use of antibodies against LH receptor, 3beta-hydroxysteroid dehydrogenase and vimentin to characterize different types of testicular tumour in dogs. Reproduction. 2001;121:287-96 pubmed
    ..Overall, this panel of antibodies can be very useful for determination of the identity of testicular tumours in which histological characterization is complicated and the pathogenesis of feminization is not clear...
  2. Fukami M, Wada Y, Okada M, Kato F, Katsumata N, Baba T, et al. Mastermind-like domain-containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence. J Biol Chem. 2008;283:5525-32 pubmed
    ..We designate CXorf6 as MAMLD1 (mastermind-like domain-containing 1) based on its characteristic structure...
  3. Libe R, Fratticci A, Lahlou N, Jornayvaz F, Tissier F, Louiset E, et al. A rare cause of hypertestosteronemia in a 68-year-old patient: a Leydig cell tumor due to a somatic GNAS (guanine nucleotide-binding protein, alpha-stimulating activity polypeptide 1)-activating mutation. J Androl. 2012;33:578-84 pubmed publisher
    ..After left orchiectomy, histologic examination confirmed the diagnosis of Leydig cell tumor, and steroid hormone levels normalized...
  4. Kim I, Young R, Scully R. Leydig cell tumors of the testis. A clinicopathological analysis of 40 cases and review of the literature. Am J Surg Pathol. 1985;9:177-92 pubmed
  5. Sirianni R, Chimento A, Malivindi R, Mazzitelli I, Ando S, Pezzi V. Insulin-like growth factor-I, regulating aromatase expression through steroidogenic factor 1, supports estrogen-dependent tumor Leydig cell proliferation. Cancer Res. 2007;67:8368-77 pubmed
    The aim of this study was to investigate the role of estrogens in Leydig cell tumor proliferation. We used R2C rat Leydig tumor cells and testicular samples from Fischer rats with a developed Leydig tumor...
  6. Ghazi A, Rahimi F, Ahadi M, Sadeghi Nejad A. Development of true precocious puberty following treatment of a Leydig cell tumor of the testis. J Pediatr Endocrinol Metab. 2001;14:1679-81 pubmed
    We report a prepubertal boy who developed true precocious puberty following unilateral orchidectomy for the treatment of a Leydig cell tumor.
  7. Agrawal U, Sharma M, Bhatnagar D, Saxena S. Leydig cell tumor: an unusual presentation. Indian J Pathol Microbiol. 2009;52:395-6 pubmed publisher
    b>Leydig cell tumor is a benign tumor of the testis and malignant transformation, if present, is rare. The case presented here showed certain features of malignancy but no infiltration beyond the capsule or metastasis...
  8. Fan J, Traore K, Li W, Amri H, Huang H, Wu C, et al. Molecular mechanisms mediating the effect of mono-(2-ethylhexyl) phthalate on hormone-stimulated steroidogenesis in MA-10 mouse tumor Leydig cells. Endocrinology. 2010;151:3348-62 pubmed publisher
    ..A model for the mechanism of MEHP action on MA-10 Leydig cell steroidogenesis is proposed...
  9. Monteagudo L, Arruga M, Bonafonte J, Ordas M, Whyte A, Gallego M, et al. Bilateral Leydig cell tumor in a six-year-old intersex goat affected by Polled Intersex Syndrome. Vet Pathol. 2008;45:42-5 pubmed publisher
    ..An advanced Leydig cell tumor, resulting in almost total destruction of the intratesticular structures, was also observed...

More Information

Publications87

  1. Owston M, Ramos Vara J. Histologic and immunohistochemical characterization of a testicular mixed germ cell sex cord-stromal tumor and a leydig cell tumor in a dog. Vet Pathol. 2007;44:936-43 pubmed
    ..We describe the histopathology and immunohistochemical characteristics of an MGSCT associated with a Leydig cell tumor in a cryptorchid testis...
  2. Maeda T, Itoh N, Kobayashi K, Takahashi A, Masumori N, Tsukamoto T. Elevated serum estradiol suggesting recurrence of Leydig cell tumor nine years after radical orchiectomy. Int J Urol. 2002;9:659-61 pubmed
    We report a case of a Leydig cell tumor that showed retroperitoneal lymph node metastasis 9 years after radical orchiectomy. Elevated serum estradiol (E2) suggested recurrence of the Leydig cell tumor...
  3. Herrera J, Davidson J, Mestman J. Hyperandrogenism due to a testosterone-secreting Sertoli-Leydig cell tumor associated with a dehydroepiandrosterone sulfate-secreting adrenal adenoma in a postmenopausal woman: case presentation and review of literature. Endocr Pract. 2009;15:149-52 pubmed
    To report a case of hyperandrogenism attributable to the presence of an adrenal adenoma secreting dehydroepiandrosterone sulfate (DHEA-S) and an ovarian Sertoli-Leydig cell tumor secreting testosterone in a postmenopausal woman.
  4. Iwamoto I, Yanazume S, Fujino T, Yoshioka T, Douchi T. Leydig cell tumor in an elderly patient with complete androgen insensitivity syndrome. Gynecol Oncol. 2005;96:870-2 pubmed
    ..Testicular tumors often develop in patients with AIS, Sertoli cell tumor and seminoma being the most common types. Leydig cell tumor in AIS is extremely rare.
  5. Basciani S, Brama M, Mariani S, De Luca G, Arizzi M, Vesci L, et al. Imatinib mesylate inhibits Leydig cell tumor growth: evidence for in vitro and in vivo activity. Cancer Res. 2005;65:1897-903 pubmed
    ..kinases, on the growth of rodent Leydig tumor cell lines in vivo and in vitro, and examined, in human Leydig cell tumor samples, the expression of activated PDGFR and c-kit and the mutations in exons of the c-kit gene commonly ..
  6. Carmignani L, Colombo R, Gadda F, Galasso G, Lania A, Palou J, et al. Conservative surgical therapy for leydig cell tumor. J Urol. 2007;178:507-11; discussion 511 pubmed
    We performed a long-term evaluation of conservative surgical treatment of benign Leydig cell tumor.
  7. Al Agha O, Axiotis C. An in-depth look at Leydig cell tumor of the testis. Arch Pathol Lab Med. 2007;131:311-7 pubmed
    b>Leydig cell tumor (LCT) is a rare tumor of the male testicular interstitium...
  8. Carron C, Meyer D, Pegg J, Engleman V, Nickols M, Settle S, et al. A peptidomimetic antagonist of the integrin alpha(v)beta3 inhibits Leydig cell tumor growth and the development of hypercalcemia of malignancy. Cancer Res. 1998;58:1930-5 pubmed
    ..A xenogeneic severe combined immune deficiency mouse/rat Leydig cell tumor model was developed for testing SC-68448 as an inhibitor of tumor growth in vivo...
  9. Santoriello A, Benevento R, Petronella P, Perna G, Canonico S. Congenital adrenal hyperplasia and Leydig cell tumor of testis. Case report and review of literature. Ann Ital Chir. 2010;81:445-8 pubmed
    ..This report describes a case of a monorchid patient suffering from Adrenogenital Syndrome and Leydig cell tumor of his testis...
  10. Wang Y, Song L, Cui L, Hong X, Zhang Z, Wang X. Monobutyl phthalate inhibits steroidogenesis by downregulating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1). J Toxicol Environ Health A. 2007;70:947-55 pubmed
    ..Data indicate that MBP interfered with steroid hormone production by affecting StAR expression in MLTC-1 cells...
  11. Froehner M, Beuthien Baumann B, Dittert D, Schuler U, Wirth M. Lack of efficacy of imatinib in a patient with metastatic Leydig cell tumor. Cancer Chemother Pharmacol. 2006;58:716-8 pubmed
    ..Studies in vitro and in a mouse model suggested that the imatinib might also be active in malignant Leydig cell tumor. We report on the--to our knowledge--first treatment experiment with imatinib in a patient with metastatic ..
  12. Inaba H, Suzuki S, Shigematsu S, Shinomiya K, Ohfusa H, Shimojo Y, et al. Leydig cell tumor and malignant lymphoma in a patient with nonclassical 21-hydroxylase deficiency. Intern Med. 2009;48:601-5 pubmed
    ..Five years earlier, he underwent simultaneous surgeries for an adrenal adenoma, a benign Leydig cell tumor (LCT), and a malignant lymphoma...
  13. Entezari P, Kajbafzadeh A, Mahjoub F, Vasei M. Leydig cell tumor in two brothers with congenital adrenal hyperplasia due to 11-? hydroxylase deficiency: a case report. Int Urol Nephrol. 2012;44:133-7 pubmed publisher
    ..Two differential diagnoses were noticed for both patients: testicular adrenal rest tumors (TART) and Leydig cell tumor (LCT). In this study the tumors were yellow, firm, and non-tender with intra-testicular location...
  14. Hekimgil M, Altay B, Yakut B, Soydan S, Ozyurt C, Killi R. Leydig cell tumor of the testis: comparison of histopathological and immunohistochemical features of three azoospermic cases and one malignant case. Pathol Int. 2001;51:792-6 pubmed
    ..cell tumors, and we believe that a panel of antibodies, including Ki-67, p53 and bcl-2, used for immunohistochemical analysis could be of diagnostic value in the identification of malignant and borderline cases of Leydig cell tumor.
  15. Carpino A, Rago V, Pezzi V, Carani C, Ando S. Detection of aromatase and estrogen receptors (ERalpha, ERbeta1, ERbeta2) in human Leydig cell tumor. Eur J Endocrinol. 2007;157:239-44 pubmed
    A Leydig cell tumor is a rare neoplasm, deriving from the interstitial cells, whose pathogenesis has not been still defined. Leydig cells of normal adult testis are known as physiological targets for estrogens...
  16. Rago V, Romeo F, Giordano F, Maggiolini M, Carpino A. Identification of the estrogen receptor GPER in neoplastic and non-neoplastic human testes. Reprod Biol Endocrinol. 2011;9:135 pubmed publisher
    ..Recently, a G-protein-coupled-receptor (GPER) has been suggested as being involved in rapid responses to estrogens in different normal and tumor cells...
  17. Carmignani L, Salvioni R, Gadda F, Colecchia M, Gazzano G, Torelli T, et al. Long-term followup and clinical characteristics of testicular Leydig cell tumor: experience with 24 cases. J Urol. 2006;176:2040-3; discussion 2043 pubmed
    ..We performed a retrospective multicenter evaluation of clinical and histological characteristics as well as followup of Leydig cell tumors...
  18. Henderson C, Ahmed A, Sesterhenn I, Belman A, Rushton H. Enucleation for prepubertal leydig cell tumor. J Urol. 2006;176:703-5 pubmed
    ..We present our experience with testis sparing enucleation of Leydig cell tumor in prepubertal boys.
  19. Sugimoto K, Matsumoto S, Nose K, Kurita T, Uemura H, Park Y, et al. A malignant Leydig cell tumor of the testis. Int Urol Nephrol. 2006;38:291-2 pubmed
    ..We performed right high orchiectomy. Histologically, Reinke's crystals and capsular invasion by tumor cells were found. Final diagnosis, the tumor was a malignant Leydig cell tumor of the testis.
  20. Cruceyra Betriu G, Tejido Sánchez A, Duarte Ojeda J, García de la Torre J, de la Morena Gallego J, Martínez Silva V, et al. [Leydig cell tumor: report of 8 cases and review of the literature]. Actas Urol Esp. 2002;26:36-40 pubmed
    b>Leydig cell tumor is the most frequent non-germ cell tumors of testis, included in the group of specialized gonadal stromal neoplasms. It has a low incidence, accounting for 1-3% of testicular neoplasms...
  21. Panesar N, Chan K, Ho C. Mouse Leydig tumor cells produce C-19 steroids, including testosterone. Steroids. 2003;68:245-51 pubmed
    The mouse Leydig tumor cells (MLTC-1) were derived from a transplantable Leydig cell tumor carried in C57BL/6 mice. The original cell line (M5480) produced testosterone and little progesterone...
  22. Di Tonno F, Tavolini I, Belmonte P, Bertoldin R, Cossaro E, Curti P, et al. Lessons from 52 patients with leydig cell tumor of the testis: the GUONE (North-Eastern Uro-Oncological Group, Italy) experience. Urol Int. 2009;82:152-7 pubmed publisher
    ..The goal of the study was to define treatment rules for the uncommon, rarely (10%) malignant and chemorefractory Leydig cell tumors (LCT) of the testis...
  23. Handa U, Sood T, Punia R. Testicular Leydig cell tumor diagnosed on fine needle aspiration. Diagn Cytopathol. 2010;38:682-4 pubmed publisher
    We report on the cytopathologic findings of a Leydig cell tumor of the testis in an adult male with no evidence of endocrine dysfunction...
  24. Cheville J, Sebo T, Lager D, Bostwick D, Farrow G. Leydig cell tumor of the testis: a clinicopathologic, DNA content, and MIB-1 comparison of nonmetastasizing and metastasizing tumors. Am J Surg Pathol. 1998;22:1361-7 pubmed
    ..Thirty cases of Leydig cell tumor of the testis (23 tumors that had not metastasized and 7 that had metastasized) were studied...
  25. Chimento A, Sirianni R, Zolea F, De Luca A, Lanzino M, Catalano S, et al. Nandrolone and stanozolol induce Leydig cell tumor proliferation through an estrogen-dependent mechanism involving IGF-I system. J Cell Physiol. 2012;227:2079-88 pubmed publisher
    ..study we aimed to determine if nandrolone and stanozolol, two commonly used AAS, could have an effect on Leydig cell tumor proliferation and if their effects could be potentiated by the concomitant use of IGF-I...
  26. Dees J, Gazouli M, Papadopoulos V. Effect of mono-ethylhexyl phthalate on MA-10 Leydig tumor cells. Reprod Toxicol. 2001;15:171-87 pubmed
    ..5-fold over control levels at MEHP concentrations of 10(-6) to 10(-3) M whereas mitochondrial volume fraction decreased. These results suggest that MEHP in Leydig cells may act as a mitochondrial toxicant and lipid metabolism disrupter. ..
  27. Baron S, Manin M, Aigueperse C, Berger M, Jean C, Veyssiere G, et al. Hormonal and developmental regulation of the mouse aldose reductase-like gene akr1b7 expression in Leydig cells. J Mol Endocrinol. 2003;31:71-81 pubmed
    ..Unexpectedly, levels of akr1b7 mRNA increased from embryonic day 15 to the day of birth and declined until adulthood while AKR1B7 protein levels followed an inverse pattern, suggesting an important role for translational mechanisms. ..
  28. Anderson M, Brogi E, Biller B. Occult Leydig cell tumor in a patient with gynecomastia. Endocr Pract. 2001;7:267-71 pubmed
    ..This ultrasound study showed a right testicular mass, which proved to be a Leydig cell tumor. The patient was referred for definitive therapy with orchiectomy...
  29. Murphy B, Lalli E, Walsh L, Liu Z, Soh J, Stocco D, et al. Heat shock interferes with steroidogenesis by reducing transcription of the steroidogenic acute regulatory protein gene. Mol Endocrinol. 2001;15:1255-63 pubmed
    ..Together these observations provide strong evidence for a mechanism of transcriptional inhibition in the down-regulation of steroidogenic acute regulatory protein expression by heat shock. ..
  30. Kato N, Fukase M, Motoyama T. Expression of a transcription factor, SOX9, in Sertoli-stromal cell tumors of the ovary. Int J Gynecol Pathol. 2004;23:180-1 pubmed
    ..These findings suggest that SOX9 expression probably plays some role in Sry-independent testicular differentiation in ovarian Sertoli-stromal cell tumors...
  31. Giatzakis C, Batarseh A, Dettin L, Papadopoulos V. The role of Ets transcription factors in the basal transcription of the translocator protein (18 kDa). Biochemistry. 2007;46:4763-74 pubmed
    ..We conclude that Sp1/Sp3 and members of the Ets family of transcription factors bind to specific binding sites in the TSPO promoter to drive basal TSPO gene transcription. ..
  32. Carr B, Rahbar S, Asmeron Y, Riggs A, Winberg C. Carcinogenicity and haemoglobin synthesis induction by cytidine analogues. Br J Cancer. 1988;57:395-402 pubmed
    ..These last two analogues appear to be relatively non-toxic, noncarcinogenic in these experiments, and retain haemoglobin activating properties with a potency similar to that of 5-azacytidine. ..
  33. Kanner W, Drachenberg C, Papadimitriou J, Wang S, Meltzer S, Sklar G. Urethral stromal tumor with pacemaker cell phenotype. Ultrastruct Pathol. 2007;31:63-71 pubmed
    ..Interstitial cells with potential pacemaker function have been recently described in the lower urinary tract, including the urethra, and this tumor may be related to this cellular phenotype. ..
  34. Shilo Y, Zisman A, Lindner A, Raz O, Strauss S, Siegel Y, et al. The predominance of benign histology in small testicular masses. Urol Oncol. 2012;30:719-22 pubmed publisher
    ..Benign lesions were found in 11 patients (8%), including epidermoid cyst (n = 4), Leydig cell tumor (n = 3), fibrosis (n = 1), adenomatoid tumor (n = 2), and 1 patient with a simple cyst...
  35. Muheilan M, Shomaf M, Tarawneh E, Murshidi M, Al Sayyed M, Murshidi M. Leydig cell tumor in grey zone: A case report. Int J Surg Case Rep. 2017;35:12-16 pubmed publisher
    b>Leydig cell tumor constitutes only about 1-3% of testicular neoplasms...
  36. Leonhartsberger N, Ramoner R, Aigner F, Stoehr B, Pichler R, Zangerl F, et al. Increased incidence of Leydig cell tumours of the testis in the era of improved imaging techniques. BJU Int. 2011;108:1603-7 pubmed publisher
    ..Use of 'observation-only' for very small lesions detected at infertility clinics is under debate. ..
  37. Salman M P, Cuello F M, Kolbach M, Gejman R, Arteaga U E. [Virilization caused by an ovarian tumor. Report of one case]. Rev Med Chil. 2011;139:1066-70 pubmed publisher
    ..A bilateral oophorectomy was performed, demonstrating the presence of a Leydig cell hilar tumor in the right ovary. The patient had a good postoperative evolution with reduction of androgen levels and reversion of alopecia. ..
  38. Shaw N, Stauffer C, Eisenberg M. Leydig cell tumor found incidentally during microscopic testicular sperm extraction in patient with mosaic Klinefelter syndrome: case report. Fertil Steril. 2016;106:1344-1347 pubmed publisher
    To report the finding and management of a case of Leydig cell tumor discovered during the infertility evaluation of a patient with mosaic Klinefelter syndrome. Single case report. Academic hospital...
  39. Foppiani L, Bernasconi D, Del Monte P, Marugo A, Toncini C, Marugo M. Leydig cell tumour-induced bilateral gynaecomastia in a young man: endocrine abnormalities. Andrologia. 2005;37:36-9 pubmed
    ..Finally, we claim that T/E2 ratio may be a useful tool in evaluating derangement of the endocrine milieu secondary to LCT. ..
  40. Olivier P, Simoneau Roy J, Francoeur D, Sartelet H, Parma J, Vassart G, et al. Leydig cell tumors in children: contrasting clinical, hormonal, anatomical, and molecular characteristics in boys and girls. J Pediatr. 2012;161:1147-52 pubmed publisher
    ..pseudopuberty, and of a 12-year-old girl with rapidly progressive virilization, both due to a pure Leydig cell tumor. Review of all cases of pediatric Leydig cell tumors published since 1999 (when the first somatic mutations ..
  41. Takamiya M, Lambard S, Huhtaniemi I. Effect of bisphenol A on human chorionic gonadotrophin-stimulated gene expression of cultured mouse Leydig tumour cells. Reprod Toxicol. 2007;24:265-75 pubmed
    ..sqRT-PCR demonstrated induction of StAR expression by hCG stimulation and no effect of BPA. In conclusion, our results indicate that BPA has only subtle modulating effects on gene expression of gonadotrophin-stimulated mLTC-1 cells. ..
  42. Cimitan M, Hodolic M, Maffione A, Borsatti E, Urso C, Colletti P, et al. Incidental detection of Leydig cell tumor via fluorine-18-Choline PET/CT in a patient with recurrent prostate cancer disease. Clin Nucl Med. 2013;38:752-4 pubmed publisher
    ..On testis removal, a Leydig cell tumor of 2.5 cm in diameter was unexpectedly found...
  43. Kriplani A, Agarwal N, Roy K, Manchanda R, Singh M. Laparoscopic management of Sertoli-Leydig cell tumors of the ovary. A report of two cases. J Reprod Med. 2001;46:493-6 pubmed
    Sertoli-Leydig cell tumor is a rare ovarian tumor with an incidence of < .5% of all ovarian tumors. Laparotomy is the standard approach to these cases.
  44. Durieux E, Descotes F, Mauduit C, Decaussin M, Guyetant S, Devouassoux Shisheboran M. The co-occurrence of an ovarian Sertoli-Leydig cell tumor with a thyroid carcinoma is highly suggestive of a DICER1 syndrome. Virchows Arch. 2016;468:631-6 pubmed publisher
    ..We report two cases of differentiated thyroid carcinoma associated with ovarian Sertoli-Leydig cell tumor and with a heterozygous DICER1 gene mutation, occurring in two unrelated young girls without pleuropulmonary ..
  45. Ulbright T, Srigley J, Hatzianastassiou D, Young R. Leydig cell tumors of the testis with unusual features: adipose differentiation, calcification with ossification, and spindle-shaped tumor cells. Am J Surg Pathol. 2002;26:1424-33 pubmed
  46. Dieckmann K. Impalpable testis cancer. BJU Int. 2004;93:638 pubmed
  47. Binsaleh S, Sircar K, Chan P. Feasibility of simultaneous testicular microdissection for sperm retrieval and ipsilateral testicular tumor resection in azoospermic men. J Androl. 2004;25:867-71 pubmed
  48. Radi Z, Miller D. Immunohistochemical expression of calretinin in canine testicular tumours and normal canine testicular tissue. Res Vet Sci. 2005;79:125-9 pubmed
    ..The present work reports, for the first time, calretinin immunohistochemical expression in normal and neoplastic canine testis. ..
  49. Fridman E, Skarda J, Ofek Moravsky E, Cordoba M. Complex multilocular cystic lesion of rete testis, accompanied by smooth muscle hyperplasia, mimicking intratesticular Leydig cell neoplasm. Virchows Arch. 2005;447:768-71 pubmed
    ..To the best of our knowledge, no similar complex lesion of the rete testis has yet been reported...
  50. Wang L, Fu Y, Peng J, Wu D, Yu M, Xu C, et al. Simvastatin-induced up-regulation of gap junctions composed of connexin 43 sensitize Leydig tumor cells to etoposide: an involvement of PKC pathway. Toxicology. 2013;312:149-57 pubmed publisher
    ..The present study suggests the possibility that upregulation of gap junctions may be utilized to increase the efficacy of anticancer chemotherapies. ..
  51. Wang X, Dyson M, Jo Y, Eubank D, Stocco D. Involvement of 5-lipoxygenase metabolites of arachidonic acid in cyclic AMP-stimulated steroidogenesis and steroidogenic acute regulatory protein gene expression. J Steroid Biochem Mol Biol. 2003;85:159-66 pubmed
    ..The results further suggested that the AA-responsive element resides in the -67/-96 region of the StAR promoter...
  52. Beck B. Letter to the editor: effects of MTBE on Leydig cell tumors in Sprague-Dawley rats: range of possible poly-3 results. Regul Toxicol Pharmacol. 2008;50:430 pubmed publisher
  53. Middendorff R, Davidoff M, Mayer B, Holstein A. Neuroendocrine characteristics of human Leydig cell tumours. Andrologia. 1995;27:351-5 pubmed
    ..Moreover, on the assumption that 'neuronal' Leydig cells exist beside 'non-neuronal' ones in normal testicular tissue, we propose the hypothesis that 'neuronal' Leydig cells can transform to tumour cells...
  54. Guanà R, Mussa A, Lala R, Tessaris D, Tessiatore P, Canavese F. Surgical enucleation of testicular leydigioma in a young child: case report and literature review. J Pediatr Endocrinol Metab. 2011;24:839-42 pubmed
    ..Clinical symptoms of all leydigioma usually are isosexual precocious pseudo-puberty due to autonomous testosterone overproduction, suppressed gonadotropin levels and a testis mass. Nowadays its therapy is debated...
  55. Tucker A, Smith J. Prostatic squamous metaplasia in a cat with interstitial cell neoplasia in a retained testis. Vet Pathol. 2008;45:905-9 pubmed publisher
    ..This is the first report of prostatic squamous metaplasia associated with testicular neoplasia in a felid...
  56. Rudolph C, Sigruener A, Hartmann A, Orso E, Bals Pratsch M, Gronwald W, et al. ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis. Horm Metab Res. 2007;39:322-35 pubmed
    ..These results relate the human YjeF_N domain containing protein family to cholesterol processing and steroid hormone metabolism in spermiogenesis and oogenesis, and AI-BP may link this function to the HDL pathway...
  57. Bohlmann M, Rabe T, Sinn H, Strowitzki T, von Wolff M. Intraoperative venous blood sampling to localize a small androgen-producing ovarian tumor. Gynecol Endocrinol. 2005;21:138-41 pubmed
    ..We report the case of a Leydig cell tumor of the ovary where diagnostic attempts to localize the source of hyperandrogenism preoperatively failed ..
  58. Valente P, Schantz H, Edmonds P, Hanjani P. Peritoneal cytology of uncommon ovarian tumors. Diagn Cytopathol. 1992;8:98-106 pubmed
    ..Careful correlation of peritoneal cytologic findings, cell-block preparations, and immunocytochemistry with the cytohistologic features of these tumors is crucial for correct tumor classification...
  59. Drudi F, Valentino M, Bertolotto M, Malpassini F, Maghella F, Cantisani V, et al. CEUS Time Intensity Curves in the Differentiation Between Leydig Cell Carcinoma and Seminoma: A Multicenter Study. Ultraschall Med. 2016;37:201-5 pubmed publisher
    ..Identification of a Leydig cell tumor is essential since the lesion is benign in 90% of cases...
  60. Carmignani L, Gadda F, Gazzano G, Nerva F, Mancini M, Ferruti M, et al. High incidence of benign testicular neoplasms diagnosed by ultrasound. J Urol. 2003;170:1783-6 pubmed
  61. Han X, Tang R, Chen X, Xu B, Qin Y, Wu W, et al. 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) decreases progesterone synthesis through cAMP-PKA pathway and P450scc downregulation in mouse Leydig tumor cells. Toxicology. 2012;302:44-50 pubmed publisher
    ..Put all together, these results suggested that progesterone synthesis decrease induced by BDE-47 may be associated with attenuation of cAMP generation and reduction of P450scc activity...
  62. Davis T. Interstitial cell adenoma of the rat testis: why is it such a problem in toxicology studies using Sprague-Dawley rats?. Toxicol Pathol. 1995;23:83-6 pubmed
    ..These predictions are consistent with experience...
  63. Alexiev B, Xu L, Heath J, Twaddell W, Phelan M. Adenomatoid tumor of the testis with intratesticular growth: a case report and review of the literature. Int J Surg Pathol. 2011;19:838-42 pubmed publisher
    ..No involvement of the epididymis or testicular membranes was identified. The morphological clues leading to the correct diagnosis of adenomatoid tumor and the possible histogenesis and differential diagnosis are discussed...
  64. Pedersen R, Brownie A. Steroidogenesis-activator polypeptide isolated from a rat Leydig cell tumor. Science. 1987;236:188-90 pubmed
    ..with comparable chromatographic behavior and biological activity has been purified from the rat H-540 Leydig cell tumor in quantities sufficient for amino acid sequencing...
  65. Erichsen A, Levy F, Golf S, Hansson V. A transplantable rat Leydig cell tumor--5. Cellular localization of beta-adrenergic and prostaglandin receptors and their effects on testosterone production. J Steroid Biochem. 1988;31:41-8 pubmed
    ..cyclase activity (AC) and testosterone production in vitro were investigated in a transplantable rat Leydig cell tumor (H-540)...
  66. Cánovas Ivorra J, Castillo Gimeno J, Michelena Barcena J, Alberto Ramírez D, Vera Román J. [Leydig cell tumor. Case report and review of the literature]. Arch Esp Urol. 2006;59:293-6 pubmed
    To report a new case of the rare Leydig cell tumor, and to perform bibliographic review.
  67. Zuckerman J, Moatamed N. Sertoli-Leydig cell tumor of the ovary masquerading as a mucinous adenocarcinoma: a frozen section pitfall. Rare Tumors. 2017;9:6861 pubmed publisher
    ..Here we report a case of Sertoli-Leydig cell tumor mistakenly diagnosed as an invasive mucinous adenocarcinoma at time of intraoperative consultation because ..
  68. Yasuda T, Banville D, Rabbani S, Hendy G, Goltzman D. Rat parathyroid hormone-like peptide: comparison with the human homologue and expression in malignant and normal tissue. Mol Endocrinol. 1989;3:518-25 pubmed
    A rat Leydig cell tumor cDNA library was screened with a 32P-labeled genomic restriction fragment encoding human PTH-like peptide (hPLP), and three cDNA clones were isolated. The largest cDNA insert contained 1146 nucleotides...
  69. Loh K, Lo J, Zaloudek C, Fitzgerald P. Occult virilizing ovarian tumours in postmenopausal women: problems in evaluation with reference to a case. Ann Acad Med Singapore. 1998;27:712-6 pubmed
    ..This approach avoids unnecessary investigations and delays in definitive management...
  70. Nakagawa R, Sakai Y, Takashima A, Terada T, Kobayashi A, Maeda M. GATA DNA-binding protein expressed in mouse I-10 Leydig testicular tumor cells. Biochem Biophys Res Commun. 2001;283:412-6 pubmed
    ..Thus the conserved zinc finger domain of GATA proteins is suggested to contribute to the binding sequence preference. GATA-4 expressed in I-10 cells was not susceptible to proteolysis coupled with cAMP signaling...
  71. Mikola M, Rahman N, Paukku T, Ahtiainen P, Vaskivuo T, Tapanainen J, et al. Gonadal tumors of mice double transgenic for inhibin-alpha promoter-driven simian virus 40 T-antigen and herpes simplex virus thymidine kinase are sensitive to ganciclovir treatment. J Endocrinol. 2001;170:79-90 pubmed
    ..The findings provide a lead for further development of somatic gene therapy for gonadal tumors...
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    ..These findings indicate that in male patients with gonadotropin-independent sexual precocity, the presence of small testicular Leydig cell tumors harboring a somatic mutation of the LH receptor gene should be considered...
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    ..Ten years later, the patient ended up well within his familial target height and remained free of disease. We report on a long-term follow-up of a prepubertal boy after testis-sparing surgery for Leydig-cell-tumour...
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    ..However, Leydig cells and a Leydig cell tumor were negative for Sry expression...
  76. Papaioannou N, Psalla D, Zavlaris M, Loukopoulos P, Tziris N, Vlemmas I. Immunohistochemical expression of dog TERT in canine testicular tumours in relation to PCNA, ki67 and p53 expression. Vet Res Commun. 2009;33:905-19 pubmed publisher
    ..Our results indicate that TERT and PCNA are useful proliferation markers but not helpful to evaluate prognosis. Instead of that ki67 and p53 could be used for predicting aggressiveness in this group of tumours...
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    ..These data collectively indicate that LHCGR mRNA is expressed as a function of the passage of cells across the G1-S phase boundary...
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    ..These tumors are usually benign; surgical resection is the accepted treatment. Masculinizing consequences of hormonal secretions may be managed by cosmetologic treatments which should not be overlooked...