squamous cell neoplasms


Summary: Neoplasms of the SQUAMOUS EPITHELIAL CELLS. The concept does not refer to neoplasms located in tissue composed of squamous elements.

Top Publications

  1. Metzger R, Schneider P, Warnecke Eberz U, Brabender J, Holscher A. Molecular biology of esophageal cancer. Onkologie. 2004;27:200-6 pubmed
    ..Regarding the dysplasia-metaplasia-carcinoma sequence of Barrett's esophagus, inhibition of apoptosis by overexpression of bcl-2 proteins occurs as an early event...
  2. Senkal C, Ponnusamy S, Rossi M, Sundararaj K, Szulc Z, Bielawski J, et al. Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo. J Pharmacol Exp Ther. 2006;317:1188-99 pubmed
    ..Moreover, treatment with L-t-C6-Pyr-Cer/GMZ combination resulted in a significant inhibition of telomerase activity and decrease in telomere length in vivo, which are among downstream targets of ceramide...
  3. Wang X, Liu R, Jin S, Fan F, Zhan Q. Overexpression of Aurora-A kinase promotes tumor cell proliferation and inhibits apoptosis in esophageal squamous cell carcinoma cell line. Cell Res. 2006;16:356-66 pubmed
  4. Fujishiro M, Yahagi N, Kakushima N, Kodashima S, Muraki Y, Ono S, et al. Endoscopic submucosal dissection of esophageal squamous cell neoplasms. Clin Gastroenterol Hepatol. 2006;4:688-94 pubmed
    ..Application of the technique is desirable for esophageal squamous cell neoplasms (SCNs), but there have been no reports on the use of this procedure in the esophagus.
  5. Ono S, Fujishiro M, Niimi K, Goto O, Kodashima S, Yamamichi N, et al. Predictors of postoperative stricture after esophageal endoscopic submucosal dissection for superficial squamous cell neoplasms. Endoscopy. 2009;41:661-5 pubmed publisher
    Although endoscopic submucosal dissection (ESD) is becoming accepted as an established treatment for superficial esophageal squamous cell neoplasms, the risks for developing postoperative stricture have not been elucidated.
  6. Fujishiro M, Kodashima S, Goto O, Ono S, Niimi K, Yamamichi N, et al. Endoscopic submucosal dissection for esophageal squamous cell neoplasms. Dig Endosc. 2009;21:109-15 pubmed publisher
    ..We believe that ESD will become a standard treatment for early esophageal cancer not only in Japan but also worldwide in the near future...
  7. Opitz O, Harada H, Suliman Y, Rhoades B, Sharpless N, Kent R, et al. A mouse model of human oral-esophageal cancer. J Clin Invest. 2002;110:761-9 pubmed
    ..These data demonstrate that L2D1(+)/p53(+/-) mice provide a well-defined, novel, and faithful model of oral-esophageal cancer, which allows for the testing of novel chemopreventive, diagnostic, and therapeutic approaches...
  8. Gojnic M, Dugalic V, Milicevic S, Arsenijevic L, Popovic N, Stefanovic A. Vaginal malignant melanoma in a healthy pregnancy--a case report. Eur J Gynaecol Oncol. 2006;27:201-3 pubmed
    ..Vaginal melanomas account for fewer than 2% of vaginal malignancies. The mean age at diagnosis is 55 years and the prognosis is poor, with an overall 5-year survival rate of 5% to 10%. ..
  9. Liu H, Shi J, Wilkerson M, Huang Y, Meschter S, Dupree W, et al. Immunohistochemical detection of p16INK4a in liquid-based cytology specimens on cell block sections. Cancer. 2007;111:74-82 pubmed

More Information

Publications111 found, 100 shown here

  1. Guerrero A, Quang P, Dekker N, Jordan R, Schmidt B. Peripheral cannabinoids attenuate carcinoma-induced nociception in mice. Neurosci Lett. 2008;433:77-81 pubmed publisher
    ..These findings support the suggestion that cannabinoids are capable of producing antinociception in carcinoma-induced pain. ..
  2. Vidal L, Gillison M. Human papillomavirus in HNSCC: recognition of a distinct disease type. Hematol Oncol Clin North Am. 2008;22:1125-42, vii pubmed publisher
    ..A diagnosis of HPV-positive HNSCC is associated not only with therapeutic relevance, but also has important implications for future prevention and screening strategies. ..
  3. Monteiro A, Russomano F, Reis A, Camargo M, Fialho S, Tristão M, et al. Effectiveness of see-and-treat for approaching pre-invasive lesions of uterine cervix. Rev Saude Publica. 2009;43:846-50 pubmed
    ..4;3.6). The difference in the mean time elapsed between patient recruitment and treatment indicates that S&T is a time-saving approach The proportion of negative cases from using the S&T approach can be regarded as low. ..
  4. Steinman S, Smith D, Chandler N, Dhurandhar B, Di Filippo L, Scheiber Pact M, et al. Morphologic, patient and interpreter profiles of high-risk human papillomavirus-positive vs.-negative cases of atypical squamous cells of undetermined significance. Acta Cytol. 2008;52:279-85 pubmed
    ..This could be used in everyday practice to further fine tune the diagnosis of ASCUS. Monitoring individual and laboratory ASCUS rates with HR-HPV positivity can be an important quality improvement indicator. ..
  5. Separovic D, Bielawski J, Pierce J, Merchant S, Tarca A, Ogretmen B, et al. Increased tumour dihydroceramide production after Photofrin-PDT alone and improved tumour response after the combination with the ceramide analogue LCL29. Evidence from mouse squamous cell carcinomas. Br J Cancer. 2009;100:626-32 pubmed publisher
  6. Chhieng D, Chen J, Connolly K, Roberson J, Eltoum I. High-risk HPV DNA detection rate in patients with atypical squamous cells and its relationship to the atypical squamous cell: squamous intraepithelial lesion ratio. Acta Cytol. 2006;50:291-4 pubmed
    ..Our ASC:SIL ratios (except for 1 pathologist) and high-risk HPV DNA detection rates were within an acceptable range. We did not observe any association between ASC:SIL ratio and high-risk HPV detection rate. ..
  7. Weinberg J. Topical therapy for actinic keratoses: current and evolving therapies. Rev Recent Clin Trials. 2006;1:53-60 pubmed
    ..Several topical treatment options have been shown to offer some significant benefit in the alleviation of these lesions. The therapies include 5-fluorouracil, imiquimod, diclofenac, colchicine and retinoids. ..
  8. Lee S, Choi Y, Choi J, Kim M, Kim J, Jung D, et al. Polymorphisms in the caspase genes and the risk of lung cancer. J Thorac Oncol. 2010;5:1152-8 pubmed publisher
    ..54, 95% confidence interval = 1.28-5.02, p = 0.008, respectively). These results suggest that a combined analysis of these three CASP gene polymorphisms might better predict the risk of lung cancer than analysis of a single polymorphism. ..
  9. de Oliveira E, Derchain S, Sarian L, Rabelo Santos S, Gontijo R, Yoshida A, et al. Prediction of high-grade cervical disease with human papillomavirus detection in women with glandular and squamous cytologic abnormalities. Int J Gynecol Cancer. 2006;16:1055-62 pubmed
    ..We conclude that in women with AGC, HPV positivity strongly correlated with the presence of glandular or squamous cervical lesion but did not help distinguishing women with squamous from those with glandular neoplasia. ..
  10. Vaĭshlia N, Zinov eva M, Sass A, Kopantsev E, Vinogradova T, Sverdlov E. [Increase of BIRC5 gene expression in non-small cell lung cancer and esophageal squamous cell carcinoma does not correlate with expression of genes SMAC/DIABLO and PML encoding its inhibitors]. Mol Biol (Mosk). 2008;42:652-61 pubmed
    ..Thus the increase of level of survivin in tumor tissues is not the result of decrease in content of its inhibitors SMAC and PML, as their content in tumor and normal cells is the same. ..
  11. Barreth D, Schepansky A, Capstick V, Johnson G, Steed H, Faught W. Atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion (ASC-H): a result not to be ignored. J Obstet Gynaecol Can. 2006;28:1095-1098 pubmed publisher
    ..Patients with an ASC-H Pap smear result should undergo timely colposcopic and histologic assessment to rule out HSIL, AIS, and cervical cancer. ..
  12. Smith E, Riddle C, Menter M, Lebwohl M. Combining systemic retinoids with biologic agents for moderate to severe psoriasis. Int J Dermatol. 2008;47:514-8 pubmed publisher
    ..Acitretin combined with biologic agents offers a promising method of managing refractory psoriasis. More research is needed to determine the long-term safety and efficacy of this combination. ..
  13. Moro Sibilot D, Lantuejoul S, Diab S, Moulai N, Aubert A, Timsit J, et al. Lung carcinomas with a basaloid pattern: a study of 90 cases focusing on their poor prognosis. Eur Respir J. 2008;31:854-9 pubmed
  14. Westin S, Bustillos D, Gano J, Fields M, Coker A, Sun C, et al. Social factors affecting treatment of cervical cancer: ethical issues and policy implications. Obstet Gynecol. 2008;111:747-51 pubmed publisher
    ..In this paper, we report a tragic case where social factors affected the outcome of a single mother with advanced cervical cancer. ..
  15. Vinod S, Sidhom M, Gabriel G, Lee M, Delaney G. Why do some lung cancer patients receive no anticancer treatment?. J Thorac Oncol. 2010;5:1025-32 pubmed publisher
  16. Remmelink M, Mijatovic T, Gustin A, Mathieu A, Rombaut K, Kiss R, et al. Identification by means of cDNA microarray analyses of gene expression modifications in squamous non-small cell lung cancers as compared to normal bronchial epithelial tissue. Int J Oncol. 2005;26:247-58 pubmed
    ..Some of these genes (such as those involved in invasion) could be used as new prognostic markers and others, like CFLAR/FLIP, could even constitute new therapeutic targets. ..
  17. Ferrandina G, Perillo A, Distefano M, D Agostino G, Gallotta V, Pierelli L, et al. Carboplatin-based neoadjuvant treatment with peripheral blood stem cell and growth factor support in locally advanced cervical cancer patients with bulky metastatic lymph nodes. Eur J Obstet Gynecol Reprod Biol. 2007;131:236-8 pubmed
  18. Zhu X, Guo Y, Li X, Ding Y, Chen L. Metastasis-associated protein 1 nuclear expression is associated with tumor progression and clinical outcome in patients with non-small cell lung cancer. J Thorac Oncol. 2010;5:1159-66 pubmed publisher
    ..Little research has been done to test the usefulness of metastasis-associated protein 1 (MTA1) as a prognostic marker for non-small cell lung cancer (NSCLC). In this study, we investigated MTA1 expression and its prognostic value for NSCLC...
  19. Cordova K, Weinstock M. Skin cancer prevention and detection--melanoma and beyond. Med Health R I. 2005;88:92-5 pubmed
  20. Goudge C, Downs L, Judson P, Argenta P. Stage II squamous cell carcinoma of the vagina in a patient with Bloom syndrome: a case report. J Reprod Med. 2007;52:557-9 pubmed
    ..There is no known treatment to decrease the occurrence of neoplasia in BS patients other than strict adherence to all known cancer surveillance screening modalities. ..
  21. Yang S, Wu C, Lee Y, Chen T, Tsai C. Postoperative recurrence as an associated factor of malignant transformation of oral dysplastic leukoplakia. ORL J Otorhinolaryngol Relat Spec. 2010;72:280-90 pubmed publisher
    ..40) was the independent prognostic factor for malignant transformation. Recurrence after laser treatment is an independent prognostic factor predicting malignant transformation of dysplastic oral leukoplakia. ..
  22. Guo M, Liu S, Lu F. Gefitinib-sensitizing mutations in esophageal carcinoma. N Engl J Med. 2006;354:2193-4 pubmed
  23. Sawan S, Mugnai R, Lopes A, Hughes A, Edmondson R. Lower-limb lymphedema and vulval cancer: feasibility of prophylactic compression garments and validation of leg volume measurement. Int J Gynecol Cancer. 2009;19:1649-54 pubmed publisher
    ..The design of these studies should take into account the observer-related variability in measuring leg volume or consider alternative methods. ..
  24. Levitt J, Hunter M, Mujat C, McLaughlin Drubin M, Munger K, Georgakoudi I. Diagnostic cellular organization features extracted from autofluorescence images. Opt Lett. 2007;32:3305-7 pubmed
  25. Rossi R, Assad G, Buggiani G, Lotti T. Photodynamic therapy: treatment of choice for actinic cheilitis?. Dermatol Ther. 2008;21:412-5 pubmed publisher
    ..MAL-PDT seems to be the ideal treatment for actinic cheilitis and other actinic keratosis, especially on exposed parts such as the face, joining tolerability and clinical efficacy with an excellent cosmetic outcome. ..
  26. Zanfir D, Zurac S, Staniceanu F, Andreescu B, Reboşapcă A. Incidental findings during ENT routine examination for head and neck trauma. Rom J Intern Med. 2009;47:301-5 pubmed
  27. Karandikar S, Borley A, Crosby T, Williams G, Reynolds S, Radcliffe A. A five-year audit of anal cancer in Wales. Colorectal Dis. 2006;8:266-72 pubmed
    ..As recommended by NICE all patients should be referred to a multidisciplinary anal cancer team, which can provide individual treatment plans. Increased specialization could mean specialist regional MDTs for anal cancer. ..
  28. Devarapu S, Sharma S, Das S. Triggering of T cell-mediated immune responses by allogenic tumor cell vaccine in patients with oral cancer. Immunopharmacol Immunotoxicol. 2006;28:387-95 pubmed
    ..The results indicate that the allogenic whole tumor cell vaccine is able to trigger T-cell mediated immunity in patients with intraoral squamous cell carcinoma. ..
  29. Coutlee F, Trottier H, Gagnon S, Koushik A, Richardson H, Roger M, et al. Low-risk human papillomavirus type 6 DNA load and integration in cervical samples from women with squamous intraepithelial lesions. J Clin Virol. 2009;45:96-9 pubmed publisher
    ..Samples from women with LSIL contained higher HPV-6 loads than women without SIL. HPV-6 DNA was not integrated into cellular DNA in these samples. ..
  30. Sun X, Wang J, Boecking A. [Diagnostic and prognostic use of DNA-Image-Cytometry in cervical squamous intraepithelial lesions and invasive carcinoma]. Zhonghua Bing Li Xue Za Zhi. 2005;34:435-7 pubmed
  31. Prince M, Ailles L. Cancer stem cells in head and neck squamous cell cancer. J Clin Oncol. 2008;26:2871-5 pubmed publisher
    ..Further study of HNSCC stem cells will increase our knowledge of this devastating disease and allow us to develop novel treatments. ..
  32. Li H, Zhang W, Wu L, Znang R, Bai P. [Clinicopathologic study of 24 patients with vulvar intraepithelial neoplasia III]. Zhonghua Zhong Liu Za Zhi. 2005;27:306-8 pubmed
    ..Treatment should be individualized and either extended local excision or simple vulvectomy is appropriate. Periodical follow-up should be done. ..
  33. Yang Z, Schumaker L, Egorin M, Zuhowski E, Guo Z, Cullen K. Cisplatin preferentially binds mitochondrial DNA and voltage-dependent anion channel protein in the mitochondrial membrane of head and neck squamous cell carcinoma: possible role in apoptosis. Clin Cancer Res. 2006;12:5817-25 pubmed
    ..Cisplatin binding to nDNA is not necessary for induction of apoptosis in HNSCC, which can result from direct action of cisplatin on mitochondria. ..
  34. Iguchi Y, Niwa Y, Miyahara R, Nakamura M, Banno K, Nagaya T, et al. Pilot study on confocal endomicroscopy for determination of the depth of squamous cell esophageal cancer in vivo. J Gastroenterol Hepatol. 2009;24:1733-9 pubmed publisher
    ..84 and 0.75, respectively. Scoring and quantification of confocal endomicroscopic images may be useful for the differential diagnosis and diagnosis of superficial invasion by squamous cell carcinoma. ..
  35. Pettersson B, Andersson S, Hellman K, Hellström A. Invasive carcinoma of the uterine cervix associated with pregnancy: 90 years of experience. Cancer. 2010;116:2343-9 pubmed publisher
    ..The objective was to retrospectively study changes in the distribution of cervical carcinoma (CC) by age, disease stage, histopathology, survival, and the development of second primary cancers...
  36. Ahn M, Lee J, Park Y, Ahn J, Ziogas A, Zell J, et al. Korean ethnicity as compared with white ethnicity is an independent favorable prognostic factor for overall survival in non-small cell lung cancer before and after the oral epidermal growth factor receptor tyrosine kinase inhibitor era. J Thorac Oncol. 2010;5:1185-96 pubmed publisher
    ..In addition, greater survival benefit among Korean patients with NSCLC was noted in the postepidermal growth factor receptor tyrosine kinase inhibitor era (2002 and after) compared with US white ethnicity. ..
  37. Kornovski I, Gorchev G. [Histopathological findings in postoperative specimens in cervical cancer patients (IB2-IVA) after neoadjuvant chemotherapy and preoperative radiotherapy]. Akush Ginekol (Sofiia). 2007;46:28-34 pubmed
    ..cerv. - 15,6%, infiltration in isthmus uteri- 8,9% and ovarian metastases - 4,4%. NCT followed by surgical treatment leads to histological results in the postoperative specimen that are not worse than the standard preoperative RT ..
  38. Sterry W. Skin diseases with high public health impact. Nonmelanoma skin cancer. Eur J Dermatol. 2007;17:562-3 pubmed
  39. Kim J, Han J, Shim Y, Park J, Kim D. Aberrant methylation of H-cadherin (CDH13) promoter is associated with tumor progression in primary nonsmall cell lung carcinoma. Cancer. 2005;104:1825-33 pubmed
    ..In addition, H-cadherin methylation may be a valuable candidate molecular marker for the early detection of NSCLC. ..
  40. Karaca O, Canbaz S, Gur O, Duran E. Bilateral venous thrombosis and lymphedema in upper extremities of patient with lung cancer. J Cardiovasc Surg (Torino). 2005;46:523-4 pubmed
  41. Gomes C, Gomez R. MicroRNA and oral cancer: future perspectives. Oral Oncol. 2008;44:910-4 pubmed publisher
    ..The emergence of miRNA knowledge, and its potential interactive action with such alterations, therefore creates a new understanding of cell transformation. ..
  42. Niyazi M, Marini P, Daniel P, Humphreys R, Jendrossek V, Belka C. Efficacy of triple therapies including ionising radiation, agonistic TRAIL antibodies and cisplatin. Oncol Rep. 2009;21:1455-60 pubmed
    ..Our data suggest that targeted agents can be effectively added to existing multimodal therapy approaches which might open new perspectives in radiation oncology. ..
  43. Cao W, Cavacini L, Tillman K, Posner M. CD40 function in squamous cell cancer of the head and neck. Oral Oncol. 2005;41:462-9 pubmed
    ..CD40 induces secretion of specific proinflammatory and proangiogenic cytokines, inhibits spontaneous and Fas-induced apoptosis and increases EGFr phosphorylation. CD40 signaling may enhance the survival of SCCHN and tumor stroma. ..
  44. Adegbidi H, Yedomon H, Atadokpede F, Balley Pognon M, do Ango Padonou F. Skin cancers at the National University Hospital of Cotonou from 1985 to 2004. Int J Dermatol. 2007;46 Suppl 1:26-9 pubmed
    ..A low incidence has been reported in the black American population and in Africa, however. This study investigates the incidence of melanoma and epidermoid and basocellular carcinoma at Cotonou in Benin...
  45. Mulanovich E, Mulanovich V, Rolston K. A case of Dirofilaria pulmonary infection coexisting with lung cancer. J Infect. 2008;56:241-3 pubmed publisher
    ..Pulmonary dirofilariasis is a rare cause of lung nodules and may be present with lung cancer even more infrequently. ..
  46. Yao H, Wang H, Zhang Z, Jiang B, Luo J, Shi X. Sulforaphane inhibited expression of hypoxia-inducible factor-1alpha in human tongue squamous cancer cells and prostate cancer cells. Int J Cancer. 2008;123:1255-61 pubmed publisher
  47. Feltl D, Zavadova E, Pala M, Hozak P. Post-treatment plasma transforming growth factor beta 1 (TGF-beta1) level predicts for late morbidity in patients with advanced head and neck cancer. Neoplasma. 2005;52:393-7 pubmed
    ..252, respectively). The post-treatment plasma TGF-beta 1 level can predict late morbidity grade >1 in advanced head and neck cancer treated with radio(chemo)therapy. This could make a basis for dose escalation in selected patients. ..
  48. Fregnani J, Soares F, Novik P, Lopes A, Latorre M. Comparison of biological behavior between early-stage adenocarcinoma and squamous cell carcinoma of the uterine cervix. Eur J Obstet Gynecol Reprod Biol. 2008;136:215-23 pubmed
    ..1) To compare the anatomopathological variables and recurrence rates in patients with early-stage adenocarcinoma (AC) and squamous cell carcinoma (SCC) of the uterine cervix; (2) to identify the independent risk factors for recurrence...
  49. Lamprecht B, Porsch P, Pirich C, Studnicka M. Electromagnetic navigation bronchoscopy in combination with PET-CT and rapid on-site cytopathologic examination for diagnosis of peripheral lung lesions. Lung. 2009;187:55-9 pubmed publisher
    ..The combination of electromagnetic navigation bronchoscopy (ENB), PET-CT, and rapid on-site cytopathologic examination (ROSE) for the routine diagnostic work-up of peripheral lung lesions has not been evaluated previously...
  50. Conde Taboada A, De la Torre C, Garcia Doval I, Flórez A, Cruces M. Intravascular cholesterol clefts as an incidental finding. Am J Dermatopathol. 2004;26:518; author reply 518 pubmed
  51. Liman A, Giampoli E, Bonfiglio T. Should women with atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion, receive reflex human papillomavirus-DNA testing?. Cancer. 2005;105:457-60 pubmed
    ..The objective of this pilot study was to evaluate whether reflex human papillomavirus (HPV)-DNA testing performed on smears diagnosed as ASC-H may obviate the need for immediate colposcopic examination...
  52. Grimm C, Six L, Tomovski C, Speiser P, Joura E, Zeillinger R, et al. A common interleukin-6 promoter polymorphism in patients with vulvar cancer. J Soc Gynecol Investig. 2005;12:617-20 pubmed
    ..No data are available with respect to vulvar cancer. Therefore, we determined the prognostic potential of the common -174(G-->C) single nucleotide polymorphism in the promoter region of IL6 in a series of patients with this disease...
  53. Stoler M. ASC, TBS, and the power of ALTS. Am J Clin Pathol. 2007;127:489-91 pubmed
  54. Gurumurthy S, Hezel A, Sahin E, Berger J, Bosenberg M, Bardeesy N. LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis. Cancer Res. 2008;68:55-63 pubmed publisher
    ..Our data indicate that Lkb1 is a potent suppressor of carcinogen-induced skin and lung cancers and that downstream targets beyond the AMPK-mTOR pathway are likely mediators of Lkb1-dependent tumor suppression...
  55. Wein R, Lewis A. Synchronous reconstruction of the floor of mouth and chin with a single skin island fibular free flap. Microsurgery. 2008;28:223-6 pubmed publisher
    ..The goal this presentation is to: 1) Review the reconstructive options for anterior mandible through-and-through composite defects and 2) Instruct the audience in the application of the double-skin paddle fibular flap in selected patients...
  56. Zou H, Thomas S, Yan Z, Grandis J, Vogt A, Li L. Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells. FASEB J. 2009;23:425-32 pubmed publisher
    ..These findings are consistent with the view that RHBDF1 is critically involved in a GPCR ligand-stimulated process leading to the activation of latent EGFR ligands...
  57. Boyd S, Virolainen S, Pärssinen J, Skoog T, van Hogerlinden M, Latonen L, et al. MMP-10 (Stromelysin-2) and MMP-21 in human and murine squamous cell cancer. Exp Dermatol. 2009;18:1044-52 pubmed publisher
    ..MMP-21 does not associate with invasion of SCC but may be involved in keratinocyte differentiation...
  58. Kim M, Huang Y, Lee J, Zhong X, Jiang W, Ratovitski E, et al. Cellular transformation by cigarette smoke extract involves alteration of glycolysis and mitochondrial function in esophageal epithelial cells. Int J Cancer. 2010;127:269-81 pubmed publisher
  59. Roth M, Katki H, Wei W, Qiao Y, Bagni R, Wang G, et al. Serum cytokine analysis in a positive chemoprevention trial: selenium, interleukin-2, and an association with squamous preneoplastic disease. Cancer Prev Res (Phila). 2010;3:810-7 pubmed publisher
    ..The favorable effect of selenomethionine on esophageal dysplasia in the original trial may have been mediated in part by its effect in reducing the levels of IL-2. ..
  60. Espinosa M, Cantu D, Lopez C, De la Garza J, Maldonado V, Melendez Zajgla J. SMAC is expressed de novo in a subset of cervical cancer tumors. BMC Cancer. 2004;4:84 pubmed
    ..It binds IAPs, allowing caspase activation and cell death. In view of its activity it might participate in carcinogenesis. In the present study, we analyzed Smac expression in a panel of cervical cancer patients...
  61. Ludlow A, Yee K, Lipman R, Bronson R, Weinreb P, Huang X, et al. Characterization of integrin beta6 and thrombospondin-1 double-null mice. J Cell Mol Med. 2005;9:421-37 pubmed
    ..They also indicate that alphavbeta6 functions as a tumor suppressor gene and that activation of TGFbeta by TSP-1 and alphavbeta6 contributes to normal tissue architecture and function...
  62. Conway W, van der Voort van Zyp J, Thamilselvan V, Walsh M, Crowe D, Basson M. Paxillin modulates squamous cancer cell adhesion and is important in pressure-augmented adhesion. J Cell Biochem. 2006;98:1507-16 pubmed
    ..Targeting paxillin in patients with malignancy and minimal tumor manipulation during surgical resection may be important therapeutic adjuncts...
  63. Riva E, Serraino D, Pierangeli A, Bambacioni F, Zaniratti S, Minosse C, et al. Markers of human papillomavirus infection and their correlation with cervical dysplasia in human immunodeficiency virus-positive women. Clin Microbiol Infect. 2007;13:94-7 pubmed
    ..The HPV DNA load in both HIV-positive and HIV-negative women was significantly higher in squamous intra-epithelial lesions than in negative Pap smears...
  64. Androutsopoulos G, Adonakis G, Ravazoula P, Kourounis G. Vaginal cancer in a patient treated for cervical intraepithelial neoplasia (CIN 3): case report. Eur J Gynaecol Oncol. 2006;27:638-9 pubmed
    ..In women who have undergone total hysterectomy for cervical intraepithelial neoplasia or cervical cancer, postoperative cytologic and colposcopic follow-up of the vagina is necessary...
  65. Guo L, Zhang F, Cai Y, Liu T. Expression profiling of integrins in lung cancer cells. Pathol Res Pract. 2009;205:847-53 pubmed publisher
    ..RAGE is a promising technique for studying the expression profiles of genes, such as integrins in cancer cells...
  66. Kim J, Do Y, Park K, Kim M, Lee K, Bae S, et al. A multi-center phase II study of docetaxel plus cisplatin as first-line therapy in patients with metastatic squamous cell esophageal cancer. Cancer Chemother Pharmacol. 2010;66:31-6 pubmed publisher
    ..The objective of this study was to evaluate the efficacy and toxicity of docetaxel and cisplatin combination chemotherapy in patients with metastatic esophageal cancer...
  67. Kontakiotis T, Manolakoglou N, Zoglopitis F, Iakovidis D, Sacas L, Papagiannis A, et al. Epidemiologic trends in lung cancer over two decades in Northern Greece: an analysis of bronchoscopic data. Monaldi Arch Chest Dis. 2009;71:147-52 pubmed
    ..The aim of this study was to explore the changing epidemiology of lung cancer in Northern Greece over the last two decades...
  68. Doherty V, Brewster D, Jensen S, Gorman D. Trends in skin cancer incidence by socioeconomic position in Scotland, 1978-2004. Br J Cancer. 2010;102:1661-4 pubmed publisher
    ..Non-melanoma skin cancer has been little studied in relation to deprivation...
  69. Ongkeko W, Altuna X, Weisman R, Wang Rodriguez J. Expression of protein tyrosine kinases in head and neck squamous cell carcinomas. Am J Clin Pathol. 2005;124:71-6 pubmed
    ..None of the kinase expressions correlated with disease-free survival. The expression of the kinases raises the possibility of treatment of HNSCC by tyrosine and serine-threonine kinase inhibitors...
  70. Sarbia M, Stahl M, von Weyhern C, Weirich G, Pühringer Oppermann F. The prognostic significance of genetic polymorphisms (Methylenetetrahydrofolate Reductase C677T, Methionine Synthase A2756G, Thymidilate Synthase tandem repeat polymorphism) in multimodally treated oesophageal squamous cell carcinoma. Br J Cancer. 2006;94:203-7 pubmed
    ..Determination of MTHFR C677T and TS tandem repeat polymorphism has no predictive value...
  71. Musso Lassalle S, Butori C, Bailleux S, Santini J, Franc B, Hofman P. A diagnostic pitfall: nodular tumor-like squamous metaplasia with Hashimoto's thyroiditis mimicking a sclerosing mucoepidermoid carcinoma with eosinophilia. Pathol Res Pract. 2006;202:379-83 pubmed
    ..We present the different histological criteria, allowing us to eliminate an SMC and other neoplastic tumors of the thyroid. The etiology of this tumor-like lesion, which is still under debate, is discussed...
  72. Longatto Filho A, Erzen M, Branca M, Roteli Martins C, Naud P, Derchain S, et al. Human papillomavirus testing as an optional screening tool in low-resource settings of Latin America: experience from the Latin American Screening study. Int J Gynecol Cancer. 2006;16:955-62 pubmed
    ..0% for cancer, with respective decline of positive predictive value. These data suggest that HPV testing with HC II assay might be a viable screening tool among this population with relatively high prevalence of cervical disease...
  73. Ramanakumar A, Parent M, Siemiatycki J. Risk of lung cancer from residential heating and cooking fuels in Montreal, Canada. Am J Epidemiol. 2007;165:634-42 pubmed
    ..5 (95% confidence interval: 1.5, 3.6; n = 253). The findings for women suggest the need for research dedicated to exploring this association, with particular emphasis on improved exposure assessment...
  74. Sheikh Ali M, Gunduz M, Nagatsuka H, Gunduz E, Cengiz B, Fukushima K, et al. Expression and mutation analysis of epidermal growth factor receptor in head and neck squamous cell carcinoma. Cancer Sci. 2008;99:1589-94 pubmed publisher
    ..02, P = 0.032, respectively). Similar to patients from western ethnicity, mutations are absent or rare in Japanese HNSCC. Protein overexpression rather than mutation might be responsible for activation of the EGFR pathway in HNSCC...
  75. Crohns M, Saarelainen S, Kankaanranta H, Moilanen E, Alho H, Kellokumpu Lehtinen P. Local and systemic oxidant/antioxidant status before and during lung cancer radiotherapy. Free Radic Res. 2009;43:646-57 pubmed publisher
    ..RT shifts the oxidant/antioxidant balance towards lipid peroxidation, although the antioxidant defense mechanisms of the body appear to counteract the increased oxidative stress rather effectively...
  76. DiFurio M, Mailhiot T, Sundborg M, Nauschuetz K. Comparison of the clinical significance of the Papanicolaou test interpretations LSIL cannot rule out HSIL and ASC-H. Diagn Cytopathol. 2010;38:313-7 pubmed publisher
    ..Based on our results, we recommend (1)LSIL/ASC-H to be added to TBS classification and (2) Pap test cases of LSIL/ASC-H may need to be clinically followed in a manner similar to ASC-H, i.e., colposcopy for all patients...
  77. Cytryn A, Russomano F, Camargo M, Zardo L, Horta N, Fonseca R, et al. Prevalence of cervical intraepithelial neoplasia grades II/III and cervical cancer in patients with cytological diagnosis of atypical squamous cells when high-grade intraepithelial lesions (ASC-H) cannot be ruled out. Sao Paulo Med J. 2009;127:283-7 pubmed
  78. Yildirim M, Tasli F, Bayam M, Postaci H. A rare cause of small bowel transection: metastatic lung cancer. Med Princ Pract. 2010;19:232-4 pubmed publisher
    ..To present a case of small bowel perforation due to metastatic lung cancer...
  79. Harrington C, James M, Wynne C. Radiation myelopathy after 36 Gy in 12 fractions palliative chest radiotherapy for squamous cell cancer of the lung: case report and review of published studies. Clin Oncol (R Coll Radiol). 2010;22:561-3 pubmed publisher
    ..The maximum spinal cord dose was 38.9 Gy. The possible contributions of portal imaging and gemcitabine are discussed and the literature reviewed...
  80. Takahashi H, Nakajima S, Sakata I, Ishida Yamamoto A, Iizuka H. Photodynamic therapy using a novel photosensitizer, ATX-S10(Na): comparative effect with 5-aminolevulinic acid on squamous cell carcinoma cell line, SCC15, ultraviolet B-induced skin tumor, and phorbol ester-induced hyperproliferative skin. Arch Dermatol Res. 2005;296:496-502 pubmed
    ..Our results indicate that ATX-S10(Na) PDT might be more effective than ALA PDT for the treatment of various skin diseases...
  81. Scurry J. International Society for the Study of Vulvovaginal Disease abandons grading of vulvar intraepithelial neoplasia. Australas J Dermatol. 2006;47:146-8 pubmed
  82. Sweny P. Infection and cancer following renal transplantation. Saudi J Kidney Dis Transpl. 2006;17:189-99 pubmed
    ..New infectious organisms continue to be identified [e.g. Burkitt's Virus (BKV), West Nile virus and Avian influenza) and will continue to tax the ingenuity of transplant physicians and microbiologists...
  83. Li W, Tran N, Lee S, O Brien C, Tse G, Scolyer R, et al. New evidence for geographic variation in the role of human papillomavirus in tonsillar carcinogenesis. Pathology. 2007;39:217-22 pubmed
    ..This study provides the first data on HPV in tonsillar cancers from Hong Kong...
  84. Johnston E, Logani S. Cytologic diagnosis of atypical squamous cells of undetermined significance in perimenopausal and postmenopausal women: lessons learned from human Papillomavirus DNA testing. Cancer. 2007;111:160-5 pubmed
    ..Reflex human papillomavirus (HPV) testing provides an opportunity to distinguish cytologic features of significance from those within the spectrum of benign cellular change in this age group...
  85. McDougall J, Madeleine M, Daling J, Li C. Racial and ethnic disparities in cervical cancer incidence rates in the United States, 1992-2003. Cancer Causes Control. 2007;18:1175-86 pubmed
    ..Differences in cervical cancer incidence rates by race/ethnicity persist in the United States. We examined these differences by histologic type and by various patient and socioeconomic characteristics...
  86. Hengge U. Role of viruses in the development of squamous cell cancer and melanoma. Adv Exp Med Biol. 2008;624:179-86 pubmed publisher
    ..Melanoma-associated retrovirus (MelARV) has been detected in mice and men and was shown to subvert immunosurveillance besides insertional mutagenesis. The state of the art of viral participation in melanomagenesis will be discussed...
  87. Simen Kapeu A, La Ruche G, Kataja V, Yliskoski M, Bergeron C, Horo A, et al. Tobacco smoking and chewing as risk factors for multiple human papillomavirus infections and cervical squamous intraepithelial lesions in two countries (Côte d'Ivoire and Finland) with different tobacco exposure. Cancer Causes Control. 2009;20:163-70 pubmed publisher
    ..In the latter, the risk was statistically significant. Our findings emphasize the need for health initiatives targeted to prevent tobacco smoking or chewing among women especially in less industrialized countries...
  88. Minkoff H, Zhong Y, Burk R, Palefsky J, Xue X, Watts D, et al. Influence of adherent and effective antiretroviral therapy use on human papillomavirus infection and squamous intraepithelial lesions in human immunodeficiency virus-positive women. J Infect Dis. 2010;201:681-90 pubmed publisher
    ..Prior studies, however, did not consider patients' adherence to their regimens or HAART effectiveness (viral suppression)...
  89. Narendra H, Tankshali R. Prevalence and pattern of nodal metastasis in pT4 gingivobuccal cancers and its implications for treatment. Indian J Cancer. 2010;47:328-31 pubmed publisher
    ..Most studies available on the pattern are from the western world and for early cancers of the tongue and floor of the mouth...
  90. Verhagen A, Bulten J, Shirango H, Thunnissen F, van der Drift M, van der Bruggen W, et al. The clinical value of lymphatic micrometastases in patients with non-small cell lung cancer. J Thorac Oncol. 2010;5:1201-5 pubmed publisher
    ..The goal of our study was to determine whether recurrent disease is associated with the presence of lymphatic micrometastases and/or isolated tumor cells, at the time of the lung resection...
  91. Harada K, Supriatno -, Kawaguchi S, Onoue T, Kawashima Y, Yoshida H, et al. High antitumor activity using intratumoral injection of plasmid DNA with mutant-type p27Kip1 gene following in vivo electroporation. Oncol Rep. 2005;13:201-6 pubmed
  92. Murthy R, Honavar S, Vemuganti G, Burman S, Naik M, Parathasaradhi A. Ocular surface squamous neoplasia in Papillon-Lefevre syndrome. Am J Ophthalmol. 2005;139:207-9 pubmed
    ..To report the occurrence of ocular surface squamous neoplasia (OSSN) in a patient with Papillon-Lefevre syndrome...