ehrlich tumor carcinoma


Summary: A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.

Top Publications

  1. da Silva R, da Silva M, Vilela L, Fecchio D. Cytokine profile of Ehrlich ascites tumor treated with Bothrops jararaca venom. Mediators Inflamm. 2002;11:197-201 pubmed
    ..Furthermore, we suggest that the IL-6 detected in the present study is produced by the EAT cells and the suppression of its production could be associated with the antitumor effect of BjV...
  2. Majumder S, Panda G, Kumar Choudhuri S. Synthesis, characterization and biological properties of a novel copper complex. Eur J Med Chem. 2003;38:893-8 pubmed
    ..GSH depleting property of the complex may be utilized to sensitize drug resistant cells where resistance is due to elevated level of GSH...
  3. Suntres Z, Lui E. Prooxidative effect of copper--metallothionein in the acute cytotoxicity of hydrogen peroxide in Ehrlich ascites tumour cells. Toxicology. 2006;217:155-68 pubmed
    ..These data suggest that cells with high levels of Cu-MT may be particularly susceptible to oxidative stress...
  4. Majumder S, Dutta P, Mookerjee A, Choudhuri S. The role of a novel copper complex in overcoming doxorubicin resistance in Ehrlich ascites carcinoma cells in vivo. Chem Biol Interact. 2006;159:90-103 pubmed
    ..CuNG causes down regulation of all these three proteins in EAC/Dox cells. The effect of CuNG as RMA is better than BSO in many aspects...
  5. Majumder S, Dutta P, Choudhuri S. The role of copper in development of drug resistance in murine carcinoma. Med Chem. 2005;1:563-73 pubmed
  6. Olishevsky S, Burlaka A, Sidorik E, Shlyakhovenko V, Garpenko Y, Kozak V. Modulation of ROS/NO production by murine peritoneal macrophages in response to bacterial CpG DNA stimulation. Exp Oncol. 2006;28:114-20 pubmed
    ..To investigate the features of metabolic activation induced by bacterial CpG DNA (bCpG DNA) in peritoneal macrophages (PMphis)...
  7. Mookerjee A, Mookerjee Basu J, Dutta P, Majumder S, Bhattacharyya S, Biswas J, et al. Overcoming drug-resistant cancer by a newly developed copper chelate through host-protective cytokine-mediated apoptosis. Clin Cancer Res. 2006;12:4339-49 pubmed
    ..Herein, we have determined the efficacy of CuNG in overcoming multidrug-resistant cancer using drug-resistant murine and human cancer cell lines...
  8. Bhattacharyya A, Choudhuri T, Pal S, Chattopadhyay S, K Datta G, Sa G, et al. Apoptogenic effects of black tea on Ehrlich's ascites carcinoma cell. Carcinogenesis. 2003;24:75-80 pubmed
    ..All these observations together signify that black tea-induced apoptogenic signals overrode the growth-arresting message of p21, thereby leading the tumor cells towards death...
  9. Ghosh S, Roy S, Banerjee M, Maity P. Modulation of tumor induced angiogenesis in Ehrlich ascites tumor. J Exp Clin Cancer Res. 2004;23:681-90 pubmed
    ..Treatment with enzyme reduced serum VEGF levels of the tumor induced animals. In vitro VEGF production by EAC cells was reduced in a concentration dependent manner in presence of glutamine analogue...

More Information

Publications106 found, 100 shown here

  1. Silva A, Serakides R, Ferreira E, Moraes J, Ocarino N, Cassali G. [Effect of hypothyroidism on the solid form of Ehrlich tumor in intact or castrated adult female mice]. Arq Bras Endocrinol Metabol. 2004;48:867-74 pubmed
    ..In addition, the isolated effect of castration caused only mild alterations, whereas hypothyroidism associated with castration resulted in a more prominent delay in the growth rate of the Ehrlich tumor...
  2. Cebović T, Spasic S, Popovic M. Cytotoxic effects of the Viscum album L. extract on Ehrlich tumour cells in vivo. Phytother Res. 2008;22:1097-103 pubmed publisher
    ..However, changes in the antioxidative enzymes activities observed after administration of the Viscum album extract might be due to the induction of oxidative stress in the EAC cells...
  3. Venturini J, de Camargo M, Félix M, Vilani Moreno F, de Arruda M. Influence of tumour condition on the macrophage activity in Candida albicans infection. Scand J Immunol. 2009;70:10-7 pubmed publisher
  4. Cabrales L, Ciria H, Bruzón R, Quevedo M, Aldana R, De Oca L, et al. Electrochemical treatment of mouse Ehrlich tumor with direct electric current. Bioelectromagnetics. 2001;22:316-22 pubmed
  5. Roy S, Biswas S, Ray M, Ray S. Protective effect of creatine against inhibition by methylglyoxal of mitochondrial respiration of cardiac cells. Biochem J. 2003;372:661-9 pubmed
    ..The differential effect of creatine on mitochondria of cardiac and malignant cells has been discussed with reference to the therapeutic potential of methylglyoxal. ..
  6. Kaneno R, Fontanari L, Santos S, Di Stasi L, Rodrigues Filho E, Eira A. Effects of extracts from Brazilian sun-mushroom (Agaricus blazei) on the NK activity and lymphoproliferative responsiveness of Ehrlich tumor-bearing mice. Food Chem Toxicol. 2004;42:909-16 pubmed
  7. Ismail M, Ghorab M, Noaman E, Ammar Y, Heiba H, Sayed M. Novel synthesis of pyrrolo [2,3-d] pyrimidines bearing sulfonamide moieties as potential antitumor and radioprotective agents. Arzneimittelforschung. 2006;56:301-8 pubmed
    ..Moreover, compound 8d exhibited radioprotective activity. The structures of the newly synthesized compounds were established by their elemental analyses and spectral data. ..
  8. Miko M, Poturnajova M, Soucek R. Cytotoxicity and mode of action of the potential cytostatic drug oracin. Neoplasma. 2002;49:167-71 pubmed
    ..The extent of inhibition was dependent on both time and drug concentration. We found that oracin inhibited activity of topoisomerase II by 100% at concentration 5 to 15 micromol/l. ..
  9. El Khawaga O, Salem T, Elshal M. Protective role of Egyptian propolis against tumor in mice. Clin Chim Acta. 2003;338:11-6 pubmed
    ..Crude Egyptian propolis has a strong inhibitory activity against tumors. The anti-tumor mechanism may be mediated by preventing oxidative damage and induction of apoptosis. ..
  10. Alonso F, Segura J, Lora J, Lobo C, Fernández Molina B, Marquez J, et al. Sensitisation of Ehrlich ascitic tumour cells to methotrexate by inhibiting glutaminase. Anticancer Res. 2005;25:3315-20 pubmed
    ..These results provide insights into the possible role of glutaminase in cancer therapy by demonstrating that the expression of antisense mRNA for glutaminase decreases chemoresistance to some pro-apoptotic agents. ..
  11. Akev N, Turkay G, Can A, Gurel A, Yildiz F, Yardibi H, et al. Effect of Aloe vera leaf pulp extract on Ehrlich ascites tumours in mice. Eur J Cancer Prev. 2007;16:151-7 pubmed
    ..According to our results, A. vera could be proposed as a prophylactic for cancer prevention. ..
  12. Palermo Neto J, de Oliveira Massoco C, Robespierre de Souza W. Effects of physical and psychological stressors on behavior, macrophage activity, and Ehrlich tumor growth. Brain Behav Immun. 2003;17:43-54 pubmed
  13. Roy S, Maity P. Effect of glutamine analogue-acivicin on tumor induced angiogenesis in Ehrlich ascites carcinoma. Indian J Exp Biol. 2005;43:407-13 pubmed
    ..Serum VEGF level was found to decrease in the drug treated groups both after 10 and 15 days of treatment. The results thus suggest that acivicin may suppress tumoral angiogenesis through regulation of VEGF level. ..
  14. Guruvayoorappan C, Kuttan G. Immunomodulatory and antitumor activity of Biophytum sensitivum extract. Asian Pac J Cancer Prev. 2007;8:27-32 pubmed
    ..The number of plaque forming cells also enhanced significantly (p<0.001), and bone marrow cellularity and beta-esterase positive cells were also increased by the administration of B. sensitivum extract. ..
  15. Taşkin E, Akgun Dar K, Kapucu A, Osanç E, Dogruman H, Eraltan H, et al. Apoptosis-inducing effects of Morinda citrifolia L. and doxorubicin on the Ehrlich ascites tumor in Balb-c mice. Cell Biochem Funct. 2009;27:542-6 pubmed publisher
    ..Further studies are warranted to assess the dosage and safety of using noni fruit juice in conjuction with anti-cancer drugs against breast cancer...
  16. Athanasoulis T, Koutsikos J, Zerva C. What is the source of the skeletal affinity of 99mTc-V-DMSA?. Eur J Nucl Med Mol Imaging. 2004;31:1673-4; author reply 1675-6 pubmed
  17. Kumar A, D Souza S, Tickoo S, Salimath B, Singh H. Antiangiogenic and proapoptotic activities of allyl isothiocyanate inhibit ascites tumor growth in vivo. Integr Cancer Ther. 2009;8:75-87 pubmed publisher
    ..AITC arrested the growth of EAT cells by inducing apoptosis and effectively arrested cell cycle progression at the G1 phase. The results clearly suggest that AITC inhibits tumor growth by both antiangiogenic and proapoptotic mechanisms. ..
  18. Ama M, Hirayama E, Hiraki A, Kim J. Changes in fused cells induced by hvj (sendai virus): relationship of morphological changes to endocytosis of the surface membrane. Cell Biol Int. 2002;26:355-61 pubmed
    ..Experiments using an endocytotic inhibitor, methylamine, indicated that endocytosis is essential for the morphological change that occurs in the fused cells. ..
  19. Fahim F, Esmat A, Mady E, Ibrahim E. Antitumor activities of iodoacetate and dimethylsulphoxide against solid Ehrlich carcinoma growth in mice. Biol Res. 2003;36:253-62 pubmed
    ..Combined treatment increased significantly the levels of plasma LDH and erythrocytes G6PDH activities, as well as liver glycogen, and in contrast it decreased the levels of liver total protein, RNA and DNA, compared to normal controls...
  20. Hirai M, Minematsu H, Kondo N, Oie K, Igarashi K, Yamazaki N. Accumulation of liposome with Sialyl Lewis X to inflammation and tumor region: application to in vivo bio-imaging. Biochem Biophys Res Commun. 2007;353:553-8 pubmed
    ..Thus, it was proven that this liposome is useful not only as an in vivo bio-imaging reagent but also as a drug delivery system (DDS). ..
  21. Da Silva S, Chaar J, Yano T. Chemotherapeutic potential of two gallic acid derivative compounds from leaves of Casearia sylvestris Sw (Flacourtiaceae). Eur J Pharmacol. 2009;608:76-83 pubmed publisher
    ..5 mg/kg dosages of these compounds for 4 days. The pharmacokinetic studies showed that IGDE remains in the organism for a long period of time, possibly explaining the higher compound efficiency...
  22. Sannigrahi S, Mazumder U, Mondal A, Pal D, Mishra S, Roy S. Flavonoids of Enhydra fluctuans exhibit anticancer activity against Ehrlich's ascites carcinoma in mice. Nat Prod Commun. 2010;5:1239-42 pubmed
    ..All the hematological parameters, malonaldehyde content and antioxidant enzyme activity were restored towards the normal level. FEF was found to be cytotoxic in the in-vitro model. ..
  23. Agafonova I, Aminin D, Shubina L, Fedorov S. Influence of polyhydroxysteroids on [Ca(2+)](i). Steroids. 2002;67:695-701 pubmed
    ..It is suggested that the investigated compounds may act as Ca(2+)-agonists and increase Ca(2+)-transport across cell membranes. ..
  24. Pasupathy K, Nair C. Response of DNA repair enzymes in murine fibrosarcoma, lymphosarcoma and ascites cells following gamma irradiation. J Radiat Res. 2003;44:229-35 pubmed
    ..We speculate that a possible role of PARP is to coordinate the activities of other enzymes in DNA repair by selectively inhibiting certain enzymes by the ribosylation process. ..
  25. Queiroz M, Valadares M, Torello C, Ramos A, Oliveira A, Rocha F, et al. Comparative studies of the effects of Tabebuia avellanedae bark extract and beta-lapachone on the hematopoietic response of tumour-bearing mice. J Ethnopharmacol. 2008;117:228-35 pubmed publisher
    ..In addition, it is clear from our results that hematopoietic disorders produced by tumours are an important pathological condition that must be considered in drug development...
  26. Rao S, Rao P, Rao B. Preliminary investigation of the radiosensitizing activity of guduchi (Tinospora cordifolia) in tumor-bearing mice. Phytother Res. 2008;22:1482-9 pubmed publisher
    ..Since Tinospora cordifolia is being used in India for treatment of various ailments, it may offer an alternative treatment strategy for cancer in combination with gamma radiation...
  27. Bera S, Wallimann T, Ray S, Ray M. Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells. FEBS J. 2008;275:5899-909 pubmed publisher
  28. Ghorab M, El Sayed Barakat S, Saker H, Abd Rabo M. Synthesis and antitumor activity of some novel quinazoline derivatives bearing the biologically active thione moiety. Arzneimittelforschung. 2006;56:665-70 pubmed
  29. Antonov A, Kalinovsky A, Stonik V, Afiyatullov S, Aminin D, Dmitrenok P, et al. Isolation and structures of erylosides from the Caribbean sponge Erylus formosus. J Nat Prod. 2007;70:169-78 pubmed
  30. Ferreira M, Barcelos L, Teixeira M, Bakhle Y, Andrade S. Tumor growth, angiogenesis and inflammation in mice lacking receptors for platelet activating factor (PAF). Life Sci. 2007;81:210-7 pubmed
    ..Further, although growth was still associated with angiogenesis in PAFR-KO mice, growth was not correlated with inflammation (leukocyte accumulation). ..
  31. Christensen S, Kolbjørn Jensen A, Simonsen L. Aberrant 3H in Ehrlich mouse ascites tumor cell nucleotides after in vivo labeling with myo-[2-3H]- and L-myo-[1-3H]inositol: implications for measuring inositol phosphate signaling. Anal Biochem. 2003;313:283-91 pubmed
    ..L-myo-[1-3H]Inositol appears nevertheless to be a preferable alternative to myo-[2-3H]inositol for tracing the intact myo-inositol molecule after in vivo labeling, with minimized interference from aberrant 3H-labeling of nucleotides. ..
  32. Ghosh D, Bose A, Haque E, Baral R. Pretreatment with neem (Azadirachta indica) leaf preparation in Swiss mice diminishes leukopenia and enhances the antitumor activity of cyclophosphamide. Phytother Res. 2006;20:814-8 pubmed
    ..Based on these observations, it is concluded that NLP would be an effective tool to reduce CYP-induced hematological complications. ..
  33. Sitdikova S, Kiselevskii M, Sel chuk V, Amandzholov B, Voyushin K, Luchenko I, et al. Mononuclear leukocytes from mice with resected tumor induce resistance to transplantation of tumor cells to animals. Bull Exp Biol Med. 2009;148:86-8 pubmed
  34. Glushkova O, Novoselova E, Sinotova O, Vrublevskaia V, Fesenko E. [Immunomodulating effect of electromagnetic waves on production of tumor necrosis factor in mice with various rates of neoplasm growth]. Biofizika. 2002;47:376-81 pubmed
    ..We suggest that the significant immunomodulating effect of low-density microwaves can be utilized for tumor growth suppression. ..
  35. Huang Y, Zhang Z, Liu W. [Biodistribution of N-(2-hydroxypropyl) methacrylamide copolymer-bound mitoxantrone in mice bearing Ehrlich solid tumor]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2004;21:930-4 pubmed
    ..These results show the possibility of targeting anticancer drug-Mitoxantrone with secondary amino residue to the tumor tissue by HPMA copolymer as carrier. ..
  36. Sitdikova S, Amandzholov B, Kiselevskii M, Donenko F. Lectin binding to mouse blood lymphocytes during tumor growth. Bull Exp Biol Med. 2005;140:445-8 pubmed
    ..Lectin binding to lymphocytes from animals with tumors decreased by more than 50% in comparison with intact animals. Changed protein glycosylation during tumor growth is specific and differs for tumors of different origin. ..
  37. Suntres Z, Lui E. Antioxidant effect of zinc and zinc-metallothionein in the acute cytotoxicity of hydrogen peroxide in Ehrlich ascites tumour cells. Chem Biol Interact. 2006;162:11-23 pubmed publisher
    ..These data suggested that Zn-MT can be considered as an antioxidant by virtue of its thiolate groups and its Zn ions that are released in the presence of oxidative stress. ..
  38. Ferreira E, da Silva A, Serakides R, Gomes M, Cassali G. Ehrlich tumor as model to study artificial hyperthyroidism influence on breast cancer. Pathol Res Pract. 2007;203:39-44 pubmed
    ..At the end of the experiment, we noted metabolism and a decrease in cell proliferation in groups having received l-thyroxine, which were more evident in the non-castrated group (p<0.001). ..
  39. Vasconcellos M, Bezerra D, Fonseca A, Pereira M, Lemos T, Pessoa O, et al. Antitumor activity of biflorin, an o-naphthoquinone isolated from Capraria biflora. Biol Pharm Bull. 2007;30:1416-21 pubmed
  40. Nascimento F, Cruz G, Pereira P, Maciel M, Silva L, Azevedo A, et al. Ascitic and solid Ehrlich tumor inhibition by Chenopodium ambrosioides L. treatment. Life Sci. 2006;78:2650-3 pubmed
    ..This effect is probably related with anti-oxidant properties of C. ambrosioides...
  41. Jagetia G, Rao S. Evaluation of the antineoplastic activity of guduchi (Tinospora cordifolia) in Ehrlich ascites carcinoma bearing mice. Biol Pharm Bull. 2006;29:460-6 pubmed
    ..TCE exerted cytotoxic effect on tumor cells by reducing the GSH concentration and increase in LPx simultaneously...
  42. Nogueira I, Leão A, Vieira M, Benfica P, da Cunha L, Valadares M. Antitumoral and antiangiogenic activity of Synadenium umbellatum Pax. J Ethnopharmacol. 2008;120:474-8 pubmed publisher
    ..In these animals, the levels of vascular endothelial growth factor were markedly decreased after the treatment. The data presented herein could open interesting perspectives for further research of SU as a candidate anticancer agent. ..
  43. Hazra B, Sarkar R, Bhattacharyya S, Ghosh P, Chel G, Dinda B. Synthesis of plumbagin derivatives and their inhibitory activities against Ehrlich ascites carcinoma in vivo and Leishmania donovani Promastigotes in vitro. Phytother Res. 2002;16:133-7 pubmed
    ..The conversion of diospyrin to the hydroquinonoid compound also led to a substantial increase in the antileishmanial activity, while a similar conversion of plumbagin failed to do so. ..
  44. Das T, Sa G, Chattopadhyay S, Ray P. Protein A-induced apoptosis of cancer cells is effected by soluble immune mediators. Cancer Immunol Immunother. 2002;51:376-80 pubmed
    ..The present observations provide additional findings on an approach to cancer immunotherapy that causes apoptogenic insult to cancer cells. ..
  45. Shil P, Sanghvi S, Vidyasagar P, Mishra K. Enhancement of radiation cytotoxicity in murine cancer cells by electroporation: in vitro and in vivo studies. J Environ Pathol Toxicol Oncol. 2005;24:291-8 pubmed
    ..The results suggest that radiocytotoxicity of tumor cells in vitro as well as in vivo were enhanced significantly by electric pulses, which may offer a potentially improved treatment of cancer. ..
  46. Hu J, Lan X, Zhang Y, Gao Z, Wu J. A comparative study of 99mTc-YIGSR and 99mTc-MIBI uptake in tumor cells. J Huazhong Univ Sci Technolog Med Sci. 2005;25:712-4 pubmed
    ..5 +/- 2.1) % and (9.47 +/- 1.9) % at 60 min, respectively. The in vitro study suggests that 99mTc-YIGSR is superior to 99mTc-MIBI in cell uptake and has potential value in tumor imaging. ..
  47. Horiuchi Suzuki K, Konno A, Ueda M, Fukuda Y, Nishio S, Hashimoto K, et al. Skeletal affinity of Tc(V)-DMS is bone cell mediated and pH dependent. Eur J Nucl Med Mol Imaging. 2004;31:388-98 pubmed
    ..Very specific pH-sensitive Tc(V)-DMS accumulation only in the osteoclastic system was detected, and use of Tc(V)-DMS in the differential detection of osteoblastic and osteoclastic metastases is discussed. ..
  48. Jagetia G, Baliga M. Evaluation of anticancer activity of the alkaloid fraction of Alstonia scholaris (Sapthaparna) in vitro and in vivo. Phytother Res. 2006;20:103-9 pubmed
    ..5 and 18.3 days, respectively. The effective dose of 210 mg of ASERS was 3/10 of the LD50 dose, which increased the MST and AST up to 54 and 49.5 days, respectively. ..
  49. da Silva R, da Silva M, Vilela L, Fecchio D. Antitumor effect of Bothrops jararaca venom. Mediators Inflamm. 2002;11:99-104 pubmed
    ..Taken together, our results demonstrate that BjV has an important antitumor effect. This is the first report showing this in vivo effect for this venom...
  50. Vyas S, Ahmadi B, Hammond J. Complex effects of sulfhydryl reagents on ligand interactions with nucleoside transporters: evidence for multiple populations of ENT1 transporters with differential sensitivities to N-ethylmaleimide. Arch Biochem Biophys. 2002;403:92-102 pubmed
    ..The interaction of NEM with the mouse ENT1 protein may also involve additional sulphydryl groups not present in the human ENT1...
  51. Ishar M, Singh G, Singh S, Sreenivasan K, Singh G. Design, synthesis, and evaluation of novel 6-chloro-/fluorochromone derivatives as potential topoisomerase inhibitor anticancer agents. Bioorg Med Chem Lett. 2006;16:1366-70 pubmed
    ..The compounds displayed promising anticancer activity under these test systems and shall serve as useful 'leads' for further design...
  52. Goryacheva Y, Vekshina O, Yashin V, Kim Y. Fusion and endocytosis of anionic liposomes with Ehrlich ascitic carcinoma cells. Bull Exp Biol Med. 2005;140:733-5 pubmed
    ..Some liposomes are endocytosed in cells and are distributed near the inner surface of the membrane. Liposome membranes spontaneously fuse with the cells under certain conditions...
  53. Wang P, Wang X, Liu Q, Zhao X, Cao B, Zhao P. Comparision between sonodynamic effects with protoporphyrin IX and hematoporphyrin on the cytoskeleton of Ehrlich ascites carcinoma cells. Cancer Biother Radiopharm. 2010;25:55-64 pubmed publisher
    ..So, it is very important to investigate whether SDT has some influence on the cytoskeleton, and it would also be interesting to compare Pp-/ and Hp-mediated SDT on the cytoskeleton...
  54. Novoselova E, Ogai V, Sinotova O, Glushkova O, Sorokina O, Fesenko E. [Effect oh millimeter waves on the immune system in mice with experimental tumors]. Biofizika. 2002;47:933-42 pubmed
    ..It was concluded that low-intensity millimeter waves do not increase the resistance against tumor as it was shown earlier in our experiments with centimeter waves...
  55. Kurita T, Miyagishima A, Nozawa Y, Sadzuka Y, Sonobe T. A dosage design of mitomycin C tablets containing finely powdered green tea. Int J Pharm. 2004;275:279-83 pubmed
    ..PT and epigallocatechin gallate (EGCG) increased significantly in MMC uptake in Ehrlich ascites carcinoma cells as compared with the control dose-dependently in vitro...
  56. de Vieira Santos M, da Silva R, da Silva M, Fecchio D. Subpopulations of mononuclear leukocytes associated with inhibition of Ehrlich ascites tumor growth by treatment with Bothrops jararaca venom. Mediators Inflamm. 2004;13:29-32 pubmed
    ..These data suggest that the inhibition of EAT is related to the toxic action of BjV on tumor cells and/or to the proteolytic effect of the venom on the mediators produced by the cells for growth modulation...
  57. Drinyaev V, Mosin V, Kruglyak E, Novik T, Sterlina T, Ermakova N, et al. Antitumor effect of avermectins. Eur J Pharmacol. 2004;501:19-23 pubmed
    ..It was also shown that avermectins enhanced the vincristine-induced suppression of the growth of Ehrlich carcinoma, melanoma B16, and P388 lympholeukemia. Avermectins produced this effect only when injected after vincristine...
  58. Sadzuka Y, Sugiyama I, Tsuruda T, Sonobe T. Characterization and cytotoxicity of mixed polyethyleneglycol modified liposomes containing doxorubicin. Int J Pharm. 2006;312:83-9 pubmed
    ..Thus, liposomes covered with PEG-DSG and PEG-CHO have an enhanced cytotoxicity. In conclusion, it was confirmed that mix-modified liposomes using PEG-lipid with different anchors were superior...
  59. de Souza A, Coelho E, Zyngier S. Comparison of the anti-neoplastic effects of dirhodium(II) tetrapropionate and its adducts with nicotinate and isonicotinate anions in mice bearing Ehrlich tumors. Eur J Med Chem. 2006;41:1214-6 pubmed
  60. Pryluts ka S, Hryniuk I, Burlaka A, Holub O, Matyshevs ka O. [Oxidative properties of photoexcited fullerenes C60 and C60-containing composites in suspension of thymocytes and Ehrlich ascites carcinoma cells]. Ukr Biokhim Zh (1999). 2006;78:139-45 pubmed
    ..No effects of photoexcited C60-composites were detected in thymocytes suspension. The data obtained testity to perspective utility of C60-composites for optimization of photodynamic therapy methods...
  61. Sadzuka Y, Iwasaki F, Sugiyama I, Horiuchi K, Hirano T, Ozawa H, et al. Study on liposomalization of zinc-coproporphyrin I as a novel drug in photodynamic therapy. Int J Pharm. 2007;338:306-9 pubmed
    ..6) treatment were shown to be higher than that in other groups. In conclusion, it is considered that the ZnCPI liposome (pH 4.6) had the effective antitumor activity with laser irradiation without the adverse reactions...
  62. Takata R, Yanai T, Yamamoto R, Konno T. Improvement of the antitumor activity of black currant polysaccharide by an enzymatic treatment. Biosci Biotechnol Biochem. 2007;71:1342-4 pubmed
    ..In vivo, partially digested CAPS with a mean MW of approximately 20,000 showed the most potent antitumor activity against Ehrlich carcinoma in mice...
  63. Nielsen D, Jensen A, Harbak H, Christensen S, Simonsen L. Cell content of phosphatidylinositol (4,5)bisphosphate in Ehrlich mouse ascites tumour cells in response to cell volume perturbations in anisotonic and in isosmotic media. J Physiol. 2007;582:1027-36 pubmed
    ..We hypothesize that PtdInsP(2) might orchestrate this 'set-point' shift...
  64. Rajkapoor B, Sankari M, Sumithra M, Anbu J, Harikrishnan N, Gobinath M, et al. Antitumor and cytotoxic effects of Phyllanthus polyphyllus on Ehrlich ascites carcinoma and human cancer cell lines. Biosci Biotechnol Biochem. 2007;71:2177-83 pubmed
    ..MPP possessed significant antitumor and cytotoxic activity on EAC and human cancer cell lines...
  65. Pedersen S, Darborg B, Rasmussen M, Nylandsted J, Hoffmann E. The Na+/H+ exchanger, NHE1, differentially regulates mitogen-activated protein kinase subfamilies after osmotic shrinkage in Ehrlich Lettre Ascites cells. Cell Physiol Biochem. 2007;20:735-50 pubmed
    ..Long-term shrinkage elicited caspase-3 activation and a loss of cell viability, which was augmented by ERK1/2 or JNK1/2 inhibition, and attenuated by p38 MAPK inhibition...
  66. Kumar S, Kumar Mishra A, Chhikara B, Chuttani K, Kumar Sharma R. Preparation and pharmacological evaluation of a new radiopharmaceutical, technetium-99m-5-fluorouracil, for tumor scintigraphy. Hell J Nucl Med. 2008;11:91-5 pubmed
    ..In the present study, we have optimized the methodology to radiolabel it with technetium-99m ((99m)Tc) efficiently and evaluated its physicochemical and biological properties...
  67. Sogawa N, Sogawa C, Oda N, Onodera K, Furuta H. Involvement of non-mast cell histamine on Ehrlich's ascites carcinoma cell proliferation. Inflamm Res. 2002;51 Suppl 1:S69-70 pubmed
  68. Takata R, Yamamoto R, Yanai T, Konno T, Okubo T. Immunostimulatory effects of a polysaccharide-rich substance with antitumor activity isolated from black currant (Ribes nigrum L.). Biosci Biotechnol Biochem. 2005;69:2042-50 pubmed
    ..The IL-4 level was, however, still lower than that exhibited by a group of normal mice. CAPS showed a certain cytotoxicity directly against tumor cells...
  69. Arafa H, Abdel Hamid M, El Khouly A, Elmazar M, Osman A. Enhancement by dexamethasone of the therapeutic benefits of cisplatin via regulation of tumor angiogenesis and cell cycle kinetics in a murine tumor paradigm. Toxicology. 2006;222:103-13 pubmed
    ..Also, dexamethasone did not alter cisplatin-induced nephrotoxicity, thus demonstrating an improved therapeutic potential...
  70. Ozcan Arican G, Ozalpan A. Evaluation of the effect of paclitaxel, epirubicin and tamoxifen by cell kinetics parameters in estrogen-receptor-positive ehrlich ascites tumor (eat) cells growing in vitro. Acta Biol Hung. 2007;58:49-59 pubmed
    ..01 - p < 0.001). As a result, concomitant treatment combined with hormonal therapy has given improved results compared with single treatment and PAC + EPI + TAM treatments had a maximum synergistic effect for 32 hrs (p < 0.001)...
  71. Rasmussen M, Alexander R, Darborg B, Møbjerg N, Hoffmann E, Kapus A, et al. Osmotic cell shrinkage activates ezrin/radixin/moesin (ERM) proteins: activation mechanisms and physiological implications. Am J Physiol Cell Physiol. 2008;294:C197-212 pubmed
    ..In contrast, no evidence was found for the involvement of an NHE1-ezrin-PI3K-PKB pathway in counteracting shrinkage-induced cell death...
  72. Donenko F, Sitdikova S, Syrtsev A, Gradyushko A, Kiselevsky M, Serebryakova M, et al. Hemoglobin-associated proteins isolated from blood serum of Ehrlich carcinoma-bearing mice. Int J Oncol. 2008;32:885-93 pubmed
    ..In conclusion, HAP might be a novel principle of tumor regression. The clinical relevance of these findings with Ehrlich carcinoma should be investigated in the future...
  73. Yadav A, Mishra P, Jain S, Mishra P, Mishra A, Agrawal G. Preparation and characterization of HA-PEG-PCL intelligent core-corona nanoparticles for delivery of doxorubicin. J Drug Target. 2008;16:464-78 pubmed
  74. Li J, Bao Y, Zhu X, Liu J, Wang H. [Immunoregulatory activity of polysaccharopeptide and Astragalus polysaccharides on EAC tumor-bearing mice]. Zhongguo Zhong Yao Za Zhi. 2008;33:924-7 pubmed
    ..To investigate the immunoregulatory activities of polysaccharopeptide and astragalus polysaccharides on EAC tumor-bearing mice...
  75. Novikov V, Novikov G, Fesenko E. Effect of weak combined static and extremely low-frequency alternating magnetic fields on tumor growth in mice inoculated with the Ehrlich ascites carcinoma. Bioelectromagnetics. 2009;30:343-51 pubmed publisher
    ..In animals without tumors, no pathological deviations from the norm in the structure of organs and tissues occurred after exposure to weak MF, indicating that this factor per se is not toxic to the organism...
  76. De A, Chattopadhyay S. The variation in cytoplasmic distribution of mouse peritoneal macrophage during phagocytosis modulated by mangiferin, an immunomodulator. Immunobiology. 2009;214:367-76 pubmed publisher
  77. de Barros A, Cardoso V, Mota L, Leite E, de Oliveira M, Alves R. A novel D-glucose derivative radiolabeled with technetium-99m: synthesis, biodistribution studies and scintigraphic images in an experimental model of Ehrlich tumor. Bioorg Med Chem Lett. 2010;20:2478-80 pubmed publisher
    ..This compound showed high accumulation in tumor tissue with high tumor-to-muscle ratio. Thus, d-glucose-MAG(3) could be considered as agent for tumor diagnosis...
  78. Jaganathan S, Mondhe D, Wani Z, Pal H, Mandal M. Effect of honey and eugenol on Ehrlich ascites and solid carcinoma. J Biomed Biotechnol. 2010;2010:989163 pubmed publisher
    ..88%. In case of solid carcinoma, eugenol (100 mg/kg; i/p) showed 24.35% tumor growth inhibition. This work will promote the development of honey and eugenol as promising candidates in cancer chemoprevention...
  79. Pederson S, Varming C, Christensen S, Hoffmann E. Mechanisms of activation of NHE by cell shrinkage and by calyculin A in Ehrlich ascites tumor cells. J Membr Biol. 2002;189:67-81 pubmed
    ..NHE activity under both iso- and hypertonic conditions is increased by inhibition of serine/threonine phosphatases, and this effect appears to be PKC-dependent...
  80. Korekane H, Nishikawa A, Imamura K. Mechanisms mediating metabolic abnormalities in the livers of Ehrlich ascites tumor-bearing mice. Arch Biochem Biophys. 2003;412:216-22 pubmed
    ..These findings suggest that the tumor-derived ODC factor and cytokines such as IL-1alpha and TNF-alpha might function synergistically in the metabolic perturbations observed in Ehrlich ascites tumor bearers...
  81. Ning J, Zhang W, Yi Y, Yang G, Wu Z, Yi J, et al. Synthesis of beta-(1-->6)-branched beta-(1-->3) glucohexaose and its analogues containing an alpha-(1-->3) linked bond with antitumor activity. Bioorg Med Chem. 2003;11:2193-203 pubmed
    ..5-1mg/kg substantially increased the inhibition of S(180) for CPA, but decreased the toxicity caused by CPA. Some of these oligosaccharides also inhibited U(14) noumenal tumor in mice effectively...
  82. Wang L, Wang Y, Chen S, Ma J, Fu Q, Wang B. [The antitumor activity of Diosgenin in vivo and in vitro]. Zhongguo Zhong Yao Za Zhi. 2002;27:777-9 pubmed
    ..To investigate the antitumor activity of Diosgenin in vivo and in vitro...
  83. Luksiene Z, de Witte P. Hypericin as novel and promising photodynamic therapy tool: studies on intracellular accumulation capacity and growth inhibition efficiency. Medicina (Kaunas). 2003;39:677-82 pubmed
    ..Hence, the accumulation of the photosensitizer in the tumor cells should be considered as one of the prognostic factors for the determination of the therapeutic outcome...
  84. Guerra R, Pereira H, Silveira L, Olea R. Immunomodulatory properties of Alternanthera tenella Colla aqueous extracts in mice. Braz J Med Biol Res. 2003;36:1215-9 pubmed
    ..The present findings are significant for the development of alternative, inexpensive and perhaps even safer strategies for cancer treatment...
  85. Badami S, Manohara Reddy S, Kumar E, Vijayan P, Suresh B. Antitumor activity of total alkaloid fraction of solanum pseudocapsicum leaves. Phytother Res. 2003;17:1001-4 pubmed
    ..The antitumor activity observed may be due to its cytotoxic properties. However the treatment caused a significant decrease in the body weight below the normal indicating the toxicity of the treatment...
  86. Bredow J, Kretzschmar M, Wunderlich G, Dorr W, Pohl T, Franke W, et al. [Therapy of malignant ascites in vivo by 211At-labelled microspheres]. Nuklearmedizin. 2004;43:63-8 pubmed
    ..Determination of the biological effect of the alpha emitter (211)At on cellular level as well as the assessment of dosimetric data in a tumour model in vivo...
  87. Valadares M, Klein S, Queiroz M. Titanocene modulation of cytokine imbalance induced by Ehrlich ascites tumour progression. Eur J Pharmacol. 2004;503:203-8 pubmed
  88. Lora J, Alonso F, Segura J, Lobo C, Marquez J, Matés J. Antisense glutaminase inhibition decreases glutathione antioxidant capacity and increases apoptosis in Ehrlich ascitic tumour cells. Eur J Biochem. 2004;271:4298-306 pubmed
    ..Taken together, these results provide insights into the role of glutaminase in apoptosis by demonstrating that the expression of antisense mRNA for glutaminase alters apoptosis and glutathione antioxidant capacity...
  89. Hu J, Zhang Y, Lan X, Qin G, Zhang J, Hu Z. An imaging study using laminin peptide 99mTc-YIGSR in mice bearing Ehrlich ascites tumour. Chin Med J (Engl). 2005;118:753-8 pubmed
    ..The purpose is to evaluate the usefulness of (99m)Tc-YIGSR, a novel tumour radiotracer, in the receptor imaging of Ehrlich ascites tumour...
  90. Razina T, Khotimchenko Y, Zueva E, Shilova N, Amosova E, Krylova S, et al. Non-starch polysaccharides as correctors in cytostatic therapy of experimental tumors. Bull Exp Biol Med. 2006;142:351-5 pubmed
    ..We studied the effects of low-esterified pectin, calcium pectate, and alginate on the development of transplanted Ehrlich adenocarcinoma and Lewis pulmonary carcinoma and on the efficiency of cyclophosphamide treatment in mice...
  91. Gu H, You Q, Liu W, Yang Y, Zhao L, Qi Q, et al. Gambogic acid induced tumor cell apoptosis by T lymphocyte activation in H22 transplanted mice. Int Immunopharmacol. 2008;8:1493-502 pubmed publisher
    ..In summary, this report demonstrated, for the first time, that GA mainly activates T lymphocytes to induce cancer cell apoptosis in H22 transplanted mice...
  92. Lialiaris T, Papachristou F, Mourelatos C, Simopoulou M. Antineoplastic and cytogenetic effects of chlorpromazine on human lymphocytes in vitro and on Ehrlich ascites tumor cells in vivo. Anticancer Drugs. 2009;20:746-51 pubmed publisher
    ..Further investigation including other phenothiazines, biological systems, and cancer models is required...