prostatic intraepithelial neoplasia

Summary

Summary: A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.

Top Publications

  1. Price D, Stein B, Sieber P, Tutrone R, Bailen J, Goluboff E, et al. Toremifene for the prevention of prostate cancer in men with high grade prostatic intraepithelial neoplasia: results of a double-blind, placebo controlled, phase IIB clinical trial. J Urol. 2006;176:965-70; discussion 970-1 pubmed
    ..group clinical study was done to determine the incidence of prostate cancer in men with high grade prostatic intraepithelial neoplasia treated with toremifene...
  2. Couto S, Cao M, Duarte P, Banach Petrosky W, Wang S, Romanienko P, et al. Simultaneous haploinsufficiency of Pten and Trp53 tumor suppressor genes accelerates tumorigenesis in a mouse model of prostate cancer. Differentiation. 2009;77:103-11 pubmed publisher
    ..In our study, high-grade prostatic intraepithelial neoplasia (PIN) was found with high frequency at 8 weeks post-tissue recombination transplantation...
  3. Memarzadeh S, Xin L, Mulholland D, Mansukhani A, Wu H, Teitell M, et al. Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor. Cancer Cell. 2007;12:572-85 pubmed
    ..We also show that transient exposure to a paracrine growth factor may be sufficient for the initiation of oncogenic transformation. ..
  4. Tomlins S, Laxman B, Varambally S, Cao X, Yu J, Helgeson B, et al. Role of the TMPRSS2-ERG gene fusion in prostate cancer. Neoplasia. 2008;10:177-88 pubmed
    ..Transgenic mice expressing the ERG gene fusion product under androgen-regulation develop mouse prostatic intraepithelial neoplasia (PIN), a precursor lesion of prostate cancer...
  5. Furusato B, Gao C, Ravindranath L, Chen Y, Cullen J, McLeod D, et al. Mapping of TMPRSS2-ERG fusions in the context of multi-focal prostate cancer. Mod Pathol. 2008;21:67-75 pubmed
    ..onset and/or progression, we have evaluated the status of fusion transcripts in benign glands, prostatic intraepithelial neoplasia (PIN) and multiple cancer foci of each prostate...
  6. Iwata T, Schultz D, Hicks J, Hubbard G, Mutton L, Lotan T, et al. MYC overexpression induces prostatic intraepithelial neoplasia and loss of Nkx3.1 in mouse luminal epithelial cells. PLoS ONE. 2010;5:e9427 pubmed publisher
    Lo-MYC and Hi-MYC mice develop prostatic intraepithelial neoplasia (PIN) and prostatic adenocarcinoma as a result of MYC overexpression in the mouse prostate...
  7. Elmore L, Forsythe R, Forsythe H, Bright A, Nasim S, Endo K, et al. Overexpression of telomerase-associated chaperone proteins in prostatic intraepithelial neoplasia and carcinomas. Oncol Rep. 2008;20:613-7 pubmed
  8. Majumder P, Grisanzio C, O Connell F, Barry M, Brito J, Xu Q, et al. A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression. Cancer Cell. 2008;14:146-55 pubmed publisher
    Transgenic expression of activated AKT1 in the murine prostate induces prostatic intraepithelial neoplasia (PIN) that does not progress to invasive prostate cancer (CaP)...
  9. Wang L, Liu R, Li W, Chen C, Katoh H, Chen G, et al. Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate. Cancer Cell. 2009;16:336-46 pubmed publisher
    ..FOXP3 is an X-linked prostate tumor suppressor in the male. Because the male has only one X chromosome, our data represent a paradigm of "single genetic hit" inactivation-mediated carcinogenesis. ..

More Information

Publications78

  1. Klezovitch O, Risk M, Coleman I, Lucas J, Null M, True L, et al. A causal role for ERG in neoplastic transformation of prostate epithelium. Proc Natl Acad Sci U S A. 2008;105:2105-10 pubmed publisher
    ..mice results in initiation of prostate neoplasia observed as the development of focal precancerous prostatic intraepithelial neoplasia (PIN)...
  2. Furusato B, Tan S, Young D, Dobi A, Sun C, Mohamed A, et al. ERG oncoprotein expression in prostate cancer: clonal progression of ERG-positive tumor cells and potential for ERG-based stratification. Prostate Cancer Prostatic Dis. 2010;13:228-37 pubmed publisher
    ..Strong concordance of ERG-positive foci of prostatic intraepithelial neoplasia (PIN) with ERG-positive carcinoma (82 out of 85 sections with PIN, 96...
  3. Mosquera J, Perner S, Genega E, Sanda M, Hofer M, Mertz K, et al. Characterization of TMPRSS2-ERG fusion high-grade prostatic intraepithelial neoplasia and potential clinical implications. Clin Cancer Res. 2008;14:3380-5 pubmed publisher
    ..biopsies are done annually in the United States with up to 16% incidence of isolated high-grade prostatic intraepithelial neoplasia (HGPIN)...
  4. Park K, Tomlins S, Mudaliar K, Chiu Y, Esgueva R, Mehra R, et al. Antibody-based detection of ERG rearrangement-positive prostate cancer. Neoplasia. 2010;12:590-8 pubmed
    ..two patient cohorts and observed ERG expression confined to prostate cancer cells and high-grade prostatic intraepithelial neoplasia associated with ERG-positive cancer, as well as vessels and lymphocytes (where ERG has a known ..
  5. Bismar T, Yoshimoto M, Vollmer R, Duan Q, Firszt M, Corcos J, et al. PTEN genomic deletion is an early event associated with ERG gene rearrangements in prostate cancer. BJU Int. 2011;107:477-85 pubmed publisher
  6. Lee S, Poulogiannis G, Pyne S, Jia S, Zou L, Signoretti S, et al. A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice. Proc Natl Acad Sci U S A. 2010;107:11002-7 pubmed publisher
    ..Array analyses of transcription in multiple murine prostate tumor models featuring PI3K/AKT pathway activation allowed construction of a pathway signature that may be useful in predicting the prognosis of human prostate tumors. ..
  7. Cerveira N, Ribeiro F, Peixoto A, Costa V, Henrique R, Jeronimo C, et al. TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions. Neoplasia. 2006;8:826-32 pubmed
    ..been found recurrently in prostate carcinomas, but not in the presumed precursor lesion, high-grade prostatic intraepithelial neoplasia (HGPIN). However, HGPIN lesions may share chromosomal changes with prostate cancer...
  8. Devaney J, Wang S, Funda S, Long J, Taghipour D, Tbaishat R, et al. Identification of novel DNA-methylated genes that correlate with human prostate cancer and high-grade prostatic intraepithelial neoplasia. Prostate Cancer Prostatic Dis. 2013;16:292-300 pubmed publisher
    ..In addition, candidate gene-based studies have shown an association between specific gene methylation and alterations and clinicopathologic indicators of poor prognosis in PCa...
  9. Goodwin A, Jadallah S, Toubaji A, Lecksell K, Hicks J, Kowalski J, et al. Increased spermine oxidase expression in human prostate cancer and prostatic intraepithelial neoplasia tissues. Prostate. 2008;68:766-72 pubmed publisher
  10. Schwartz A, Man Y, Rezaei M, Simmens S, Berg P. BP1, a homeoprotein, is significantly expressed in prostate adenocarcinoma and is concordant with prostatic intraepithelial neoplasia. Mod Pathol. 2009;22:1-6 pubmed publisher
    ..7. In tissue sections, 12 cases with paired carcinoma and prostatic intraepithelial neoplasia (PIN) showed concordance with strong immunoreactivity...
  11. Clark J, Attard G, Jhavar S, Flohr P, Reid A, de Bono J, et al. Complex patterns of ETS gene alteration arise during cancer development in the human prostate. Oncogene. 2008;27:1993-2003 pubmed
    ..In a search for possible precursor lesions clonal ERG rearrangements were found both in high grade prostatic intraepithelial neoplasia (PIN) and in atypical in situ epithelial lesions consistent with the diagnosis of low grade PIN...
  12. Luchman H, Benediktsson H, Villemaire M, Peterson A, Jirik F. The pace of prostatic intraepithelial neoplasia development is determined by the timing of Pten tumor suppressor gene excision. PLoS ONE. 2008;3:e3940 pubmed publisher
    ..These progressed from pre-malignant changes (nuclear atypia, focal hyperplasia) and low grade prostatic intraepithelial neoplasia (PIN) at 16-20 wks post-tamoxifen exposure, to overtly malignant lesions by approximately 1 yr of ..
  13. Merrimen J, Jones G, Walker D, Leung C, Kapusta L, Srigley J. Multifocal high grade prostatic intraepithelial neoplasia is a significant risk factor for prostatic adenocarcinoma. J Urol. 2009;182:485-90; discussion 490 pubmed publisher
    There is debate in the literature on the role of high grade prostatic intraepithelial neoplasia as a risk factor for subsequent prostatic adenocarcinoma detection on prostatic needle biopsy...
  14. Doak S, Jenkins S, Hurle R, Varma M, Hawizy A, Kynaston H, et al. Bone morphogenic factor gene dosage abnormalities in prostatic intraepithelial neoplasia and prostate cancer. Cancer Genet Cytogenet. 2007;176:161-5 pubmed
    ..developed and applied to archival sections with areas of adjacent benign epithelium, high-grade prostatic intraepithelial neoplasia, and prostate carcinoma. Two hundred nuclei from each region were evaluated...
  15. Mariani S, Lionetto L, Cavallari M, Tubaro A, Rasio D, De Nunzio C, et al. Low prostate concentration of lycopene is associated with development of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia. Int J Mol Sci. 2014;15:1433-40 pubmed publisher
    ..Since pre-cancerous lesions, i.e., the high-grade prostatic intraepithelial neoplasia (HGPIN), can be detected years before progression to PC, early diagnosis and chemoprevention are ..
  16. Nomikos M, Karyotis I, Phillipou P, Constadinides C, Delakas D. The implication of initial 24-core transrectal prostate biopsy protocol on the detection of significant prostate cancer and high grade prostatic intraepithelial neoplasia. Int Braz J Urol. 2011;37:87-93; discussion 93 pubmed
    ..To assess the diagnostic value of an initial 24-sample transrectal ultrasound guided (TRUS) prostate biopsy protocol compared to the 10-core technique...
  17. Hom J, Coakley F, Simko J, Lu Y, Qayyum A, Westphalen A, et al. High-grade prostatic intraepithelial neoplasia in patients with prostate cancer: MR and MR spectroscopic imaging features--initial experience. Radiology. 2007;242:483-9 pubmed
    To retrospectively determine the magnetic resonance (MR) and MR spectroscopic imaging features of high-grade prostatic intraepithelial neoplasia (HGPIN) in patients with prostate cancer.
  18. Schoenfield L, Jones J, Zippe C, Reuther A, Klein E, Zhou M, et al. The incidence of high-grade prostatic intraepithelial neoplasia and atypical glands suspicious for carcinoma on first-time saturation needle biopsy, and the subsequent risk of cancer. BJU Int. 2007;99:770-4 pubmed
    To investigate the detection rate and extent of high-grade prostatic intraepithelial neoplasia (HGPIN) and atypical glands (AG) suspicious for prostate cancer, and the cancer risk in subsequent biopsies, diagnosed by a first 24-core ..
  19. Joshua A, Vukovic B, Braude I, Hussein S, Zielenska M, Srigley J, et al. Telomere attrition in isolated high-grade prostatic intraepithelial neoplasia and surrounding stroma is predictive of prostate cancer. Neoplasia. 2007;9:81-9 pubmed
    ..to facilitate the formation of crucial genomic aberrations both in the precursor lesion high-grade prostatic intraepithelial neoplasia (HPIN) and in CaP...
  20. Zong Y, Xin L, Goldstein A, Lawson D, Teitell M, Witte O. ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells. Proc Natl Acad Sci U S A. 2009;106:12465-70 pubmed publisher
    ..prostate epithelial cells is sufficient to induce the formation of epithelial hyperplasia and focal prostatic intraepithelial neoplasia (PIN) lesions, but not progression to carcinoma...
  21. Bethel C, Faith D, Li X, Guan B, Hicks J, Lan F, et al. Decreased NKX3.1 protein expression in focal prostatic atrophy, prostatic intraepithelial neoplasia, and adenocarcinoma: association with gleason score and chromosome 8p deletion. Cancer Res. 2006;66:10683-90 pubmed
    ..Prior studies of NKX3.1 mRNA and protein in human prostate cancer and prostatic intraepithelial neoplasia (PIN) have been conflicting, and expression in focal prostate atrophy lesions has not been ..
  22. Jiang M, Fernandez S, Jerome W, He Y, Yu X, Cai H, et al. Disruption of PPARgamma signaling results in mouse prostatic intraepithelial neoplasia involving active autophagy. Cell Death Differ. 2010;17:469-81 pubmed publisher
    ..epithelial knockout of PPARgamma in mice resulted in focal hyperplasia which developed into mouse prostatic intraepithelial neoplasia (mPIN). The grade of PIN became more severe with time...
  23. Ploussard G, Plennevaux G, Allory Y, Salomon L, Azoulay S, Vordos D, et al. High-grade prostatic intraepithelial neoplasia and atypical small acinar proliferation on initial 21-core extended biopsy scheme: incidence and implications for patient care and surveillance. World J Urol. 2009;27:587-92 pubmed publisher
    To evaluate the incidence of high-grade prostatic intraepithelial neoplasia (HGPIN) and atypical small acinar proliferation (ASAP) in an initial 21-core extended biopsy scheme and to determine the prostate cancer detection rate in the ..
  24. Elkahwaji J, Hauke R, Brawner C. Chronic bacterial inflammation induces prostatic intraepithelial neoplasia in mouse prostate. Br J Cancer. 2009;101:1740-8 pubmed publisher
    ..Although the aetiology of prostate cancer remains unknown, we hypothesised that chronic bacterial insult has a major role in prostate carcinogenesis...
  25. Denkert C, Thoma A, Niesporek S, Weichert W, Koch I, Noske A, et al. Overexpression of cyclooxygenase-2 in human prostate carcinoma and prostatic intraepithelial neoplasia-association with increased expression of Polo-like kinase-1. Prostate. 2007;67:361-9 pubmed
    ..Cyclooxygenases (COX) as well as Polo-like kinases (PLK) are involved in proliferation and cell cycle regulation and have been suggested for preventive and therapeutic approaches in prostate carcinoma...
  26. Karakiewicz P, Benayoun S, Begin L, Duclos A, Valiquette L, McCormack M, et al. Chronic inflammation is negatively associated with prostate cancer and high-grade prostatic intraepithelial neoplasia on needle biopsy. Int J Clin Pract. 2007;61:425-30 pubmed
    ..the association between chronic inflammation and prostate cancer (PCa), as well as high-grade prostatic intraepithelial neoplasia (HGPIN), in prostatic needle biopsy specimens...
  27. Scarpelli M, Mazzucchelli R, Barbisan F, Santinelli A, Lopez Beltran A, Cheng L, et al. Is there a role for prostate tumour overexpressed-1 in the diagnosis of HGPIN and of prostatic adenocarcinoma? A comparison with alpha-methylacyl CoA racemase. Int J Immunopathol Pharmacol. 2012;25:67-74 pubmed
    ..However, PTOV1 may aid in the diagnosis of PCa, at least to supplement AMACR as another positive marker of carcinoma and to potentially increase diagnostic accuracy...
  28. Gurel B, Iwata T, Koh C, Jenkins R, Lan F, Van Dang C, et al. Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis. Mod Pathol. 2008;21:1156-67 pubmed publisher
  29. Akhavan A, Keith J, Bastacky S, Cai C, Wang Y, Nelson J. The proportion of cores with high-grade prostatic intraepithelial neoplasia on extended-pattern needle biopsy is significantly associated with prostate cancer on site-directed repeat biopsy. BJU Int. 2007;99:765-9 pubmed
    To determine whether the predictive value of isolated high-grade prostatic intraepithelial neoplasia (HGPIN) for an unsampled prostate cancer on an extended biopsy is lower due to more thorough prostate sampling, and whether the ..
  30. Zhigang Z, Wenlu S. Prostate stem cell antigen (PSCA) mRNA expression in prostatic intraepithelial neoplasia: implications for the development of prostate cancer. Prostate. 2007;67:1143-51 pubmed
    Prior data clearly demonstrated the expression of prostate stem cell antigen (PSCA) mRNA in prostatic intraepithelial neoplasia (PIN) tissues...
  31. Yaskiv O, Zhang X, Simmerman K, Daly T, He H, Falzarano S, et al. The utility of ERG/P63 double immunohistochemical staining in the diagnosis of limited cancer in prostate needle biopsies. Am J Surg Pathol. 2011;35:1062-8 pubmed publisher
    ..High-grade prostatic intraepithelial neoplasia was present in 17 cases, and in 5 (29%) cases ERG was positive in high-grade prostatic ..
  32. Montironi R, Mazzucchelli R, Lopez Beltran A, Cheng L, Scarpelli M. Mechanisms of disease: high-grade prostatic intraepithelial neoplasia and other proposed preneoplastic lesions in the prostate. Nat Clin Pract Urol. 2007;4:321-32 pubmed
    High-grade prostatic intraepithelial neoplasia (HGPIN) is the most likely precursor of prostatic adenocarcinoma according to virtually all available evidence...
  33. Han K, Jeong I, Joung J, Yang S, Chung J, Seo H, et al. Prevalence of high-grade prostatic intraepithelial neoplasia in prostate gland of Korean men: comparisons between radical prostatectomy and cystoprostatectomy. Urology. 2007;70:1100-3 pubmed
    To evaluate the prevalence of high-grade prostatic intraepithelial neoplasia (HGPIN) and its association with prostate cancer in Korean men.
  34. Antonelli A, Tardanico R, Giovanessi L, Pesenti N, Gatti L, Zambolin T, et al. Predicting prostate cancer at rebiopsies in patients with high-grade prostatic intraepithelial neoplasia: a study on 546 patients. Prostate Cancer Prostatic Dis. 2011;14:173-6 pubmed publisher
    ..was to analyse the factors that predict the diagnosis of prostate cancer (PCa) after high-grade prostatic intraepithelial neoplasia (HGPIN)...
  35. Davidsson S, Fiorentino M, Andrén O, Fang F, Mucci L, Varenhorst E, et al. Inflammation, focal atrophic lesions, and prostatic intraepithelial neoplasia with respect to risk of lethal prostate cancer. Cancer Epidemiol Biomarkers Prev. 2011;20:2280-7 pubmed publisher
    ..Inflammation, focal prostatic atrophy, and prostatic intraepithelial neoplasia (PIN) are common in prostate tumor specimens, but it is not clear whether these lesions have ..
  36. Montironi R, Mazzucchelli R, Lopez Beltran A, Scarpelli M, Cheng L. Prostatic intraepithelial neoplasia: its morphological and molecular diagnosis and clinical significance. BJU Int. 2011;108:1394-401 pubmed publisher
    The aim of the present paper was to review the morphological spectrum of prostatic intraepithelial neoplasia (PIN), its relationship to carcinoma of the prostate (PCa) and its clinical significance...
  37. Park K, Dalton J, Narayanan R, Barbieri C, Hancock M, Bostwick D, et al. TMPRSS2:ERG gene fusion predicts subsequent detection of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia. J Clin Oncol. 2014;32:206-11 pubmed publisher
    High-grade prostatic intraepithelial neoplasia (HGPIN) is considered a precursor lesion of prostate cancer (PCa)...
  38. Brasil A, Favaro W, Cagnon V, Ferreira U, Billis A. Atrophy in specimens of radical prostatectomy: is there topographic relation to high-grade prostatic intraepithelial neoplasia or cancer?. Int Urol Nephrol. 2011;43:397-403 pubmed publisher
    ..whether there is any relationship of proliferative inflammatory atrophy (PIA) to high-grade prostatic intraepithelial neoplasia (HGPIN) and cancer (CA)...
  39. Yoshimoto M, Cutz J, Nuin P, Joshua A, Bayani J, Evans A, et al. Interphase FISH analysis of PTEN in histologic sections shows genomic deletions in 68% of primary prostate cancer and 23% of high-grade prostatic intra-epithelial neoplasias. Cancer Genet Cytogenet. 2006;169:128-37 pubmed
    ..These findings draw attention to the usefulness of this relatively simple FISH assay for future applications in clinical laboratories...
  40. Powell M, Casimiro M, Cordon Cardo C, He X, Yeow W, Wang C, et al. Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation. Cancer Res. 2011;71:964-75 pubmed publisher
    ..Herein, homozygous deletion of the Sirt1 gene in mice resulted in prostatic intraepithelial neoplasia (PIN) associated with reduced autophagy...
  41. Guo C, Epstein J. Intraductal carcinoma of the prostate on needle biopsy: Histologic features and clinical significance. Mod Pathol. 2006;19:1528-35 pubmed
    ..Consideration should be given to treat patients with IDC-P on biopsy aggressively even in the absence of documented infiltrating cancer...
  42. Billis A, Freitas L, Magna L, Ferreira U. Inflammatory atrophy on prostate needle biopsies: is there topographic relationship to cancer?. Int Braz J Urol. 2007;33:355-60; discussion 361-3 pubmed
    ..been suggested that the proliferative epithelium in inflammatory atrophy may progress to high-grade prostatic intraepithelial neoplasia and/or adenocarcinoma...
  43. Qingyi Z, Lin Y, Junhong W, Jian S, Weizhou H, Long M, et al. Unfavorable prognostic value of human PEDF decreased in high-grade prostatic intraepithelial neoplasia: a differential proteomics approach. Cancer Invest. 2009;27:794-801 pubmed publisher
    High-grade prostatic intraepithelial neoplasia (HGPIN) is the most likely precursor of prostate cancer, but the frequency and timing of epigenetic changes found in prostate carcinogenesis has not been extensively documented.
  44. Joniau S, Goeman L, Roskams T, Lerut E, Oyen R, Van Poppel H. Effect of nutritional supplement challenge in patients with isolated high-grade prostatic intraepithelial neoplasia. Urology. 2007;69:1102-6 pubmed
    To investigate, through a prospective follow-up study, the effects of a dietary supplementation challenge in men with isolated high-grade prostatic intraepithelial neoplasia (HGPIN).
  45. Xiao W, Zhang Q, Habermacher G, Yang X, Zhang A, Cai X, et al. U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia. Oncogene. 2008;27:1536-44 pubmed
    ..The U19/Eaf2 knockout mouse also provides a unique animal model for three important cancers: lung adenocarcinoma, B-cell lymphoma and hepatocellular carcinoma...
  46. Yee D, Narula N, Ramzy I, Boker J, Ahlering T, Skarecky D, et al. Reduced annexin II protein expression in high-grade prostatic intraepithelial neoplasia and prostate cancer. Arch Pathol Lab Med. 2007;131:902-8 pubmed
    ..Although commonly underexpressed in prostate cancer, the association of reduced expression with pathologic grade and stage is unknown...
  47. Gallo F, Chiono L, Gastaldi E, Venturino E, Giberti C. Prognostic significance of high-grade prostatic intraepithelial neoplasia (HGPIN): risk of prostatic cancer on repeat biopsies. Urology. 2008;72:628-32 pubmed publisher
    To verify prognostic significance of high-grade prostatic intraepithelial neoplasia (HGPIN) in 65 patients who underwent repeat biopsies with a mean follow-up of 36 months.
  48. Morote J, Fernandez S, Alaña L, Iglesias C, Planas J, Reventos J, et al. PTOV1 expression predicts prostate cancer in men with isolated high-grade prostatic intraepithelial neoplasia in needle biopsy. Clin Cancer Res. 2008;14:2617-22 pubmed publisher
    To analyze the expression of PTOV1 in high-grade prostatic intraepithelial neoplasia (HG-PIN) and to explore its usefulness to predict prostate cancer in patients with isolated HG-PIN in needle biopsy (prostate needle biopsy).
  49. Montironi R, Mazzucchelli R, Barbisan F, Stramazzotti D, Santinelli A, Lopez Beltran A, et al. Immunohistochemical expression of endothelin-1 and endothelin-A and endothelin-B receptors in high-grade prostatic intraepithelial neoplasia and prostate cancer. Eur Urol. 2007;52:1682-9 pubmed
    ..High-grade prostatic intraepithelial neoplasia (HGPIN) was also investigated.
  50. Guzzo T, Kutikov A, Canter D, Tomaszewski J, Magerfleish L, VanArsdalen K, et al. The clinical and pathological history of prostate cancer progression in men with a prior history of high grade prostatic intraepithelial neoplasia. Can J Urol. 2008;15:4174-8; discussion 4179 pubmed
    The natural history of high grade prostatic intraepithelial neoplasia (HGPIN) is incompletely understood limiting evidence based recommendations regarding screening and repeat biopsy intervals...
  51. Epstein J. Precursor lesions to prostatic adenocarcinoma. Virchows Arch. 2009;454:1-16 pubmed publisher
    High-grade prostatic intraepithelial neoplasia (PIN) is the one well-documented precursor to adenocarcinoma of the prostate. This review article defines both low- and high-grade PIN. Unusual variants of high-grade PIN are illustrated...
  52. Hu Y, Wang M, Veverka K, Garcia F, Stearns M. The ABCA5 protein: a urine diagnostic marker for prostatic intraepithelial neoplasia. Clin Cancer Res. 2007;13:929-38 pubmed
    ..To develop a urine diagnostic test for preneoplastic intraepithelial neoplasia of the prostate...
  53. Kelavkar U, Harya N, Hutzley J, Bacich D, Monzon F, Chandran U, et al. DNA methylation paradigm shift: 15-lipoxygenase-1 upregulation in prostatic intraepithelial neoplasia and prostate cancer by atypical promoter hypermethylation. Prostaglandins Other Lipid Mediat. 2007;82:185-97 pubmed
    ..We examined the methylation status of this specific CpG in microdissected high grade prostatic intraepithelial neoplasia (HGPIN), PCa, metastatic human prostate tissues, normal prostate cell lines and human donor (normal)..
  54. Morikawa T, Goto A, Tomita K, Tsurumaki Y, Ota S, Kitamura T, et al. Recurrent prostatic stromal sarcoma with massive high-grade prostatic intraepithelial neoplasia. J Clin Pathol. 2007;60:330-2 pubmed
    ..case of prostatic stromal sarcoma (PSS) that recurred in the pelvic cavity with massive high-grade prostatic intraepithelial neoplasia is described...
  55. Willems Jones A, Kavanagh L, Clouston D, Bolton D, Fox S, Thorne H. High grade prostatic intraepithelial neoplasia does not display loss of heterozygosity at the mutation locus in BRCA2 mutation carriers with aggressive prostate cancer. BJU Int. 2012;110:E1181-6 pubmed publisher
    ..High grade prostatic intraepithelial neoplasia (HGPIN) has been considered a precursor to prostate adenocarcinoma in some, but not all, cases of ..
  56. Tam N, Szeto C, Freudenberg J, Fullenkamp A, Medvedovic M, Ho S. Research resource: estrogen-driven prolactin-mediated gene-expression networks in hormone-induced prostatic intraepithelial neoplasia. Mol Endocrinol. 2010;24:2207-17 pubmed publisher
    Cotreatment with testosterone (T) and 17?-estradiol (E2) is an established regimen for inducing of prostatic intraepithelial neoplasia (PIN) and prostate cancer in rodent models...
  57. Ayala A, Ro J. Prostatic intraepithelial neoplasia: recent advances. Arch Pathol Lab Med. 2007;131:1257-66 pubmed
    There have been 2 putative prostatic cancer precursors, prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia (adenosis), but PIN remains as a well-known precancerous condition.
  58. Fowke J, Motley S, Barocas D, Cookson M, Concepcion R, Byerly S, et al. The associations between statin use and prostate cancer screening, prostate size, high-grade prostatic intraepithelial neoplasia (PIN), and prostate cancer. Cancer Causes Control. 2011;22:417-26 pubmed publisher
    ..We also describe the association between statin use and prostate cancer and high-grade prostatic intraepithelial neoplasia (PIN) before and after controlling for prostate cancer screening indices associated with statin use.
  59. Chua C, Chiu Y, Yuen H, Chan K, Wang X, Ling M, et al. Differential expression of MSX2 in nodular hyperplasia, high-grade prostatic intraepithelial neoplasia and prostate adenocarcinoma. APMIS. 2010;118:918-26 pubmed publisher
    ..nuclear expression was significantly higher in nodular hyperplasia when compared with high-grade prostatic intraepithelial neoplasia (PIN), while MSX2 nuclear expression in prostate adenocarcinoma was higher than that in high-grade ..
  60. Zhang S, Pavlovitz B, Tull J, Wang Y, Deng F, Fuller C. Detection of TMPRSS2 gene deletions and translocations in carcinoma, intraepithelial neoplasia, and normal epithelium of the prostate by direct fluorescence in situ hybridization. Diagn Mol Pathol. 2010;19:151-6 pubmed publisher
    ..In this study, we examined adenocarcinomas, prostatic intraepithelial neoplasia (PIN), and normal epithelium of the prostate retrieved from radical prostatectomy specimens to ..
  61. ACEVEDO V, Gangula R, Freeman K, Li R, Zhang Y, Wang F, et al. Inducible FGFR-1 activation leads to irreversible prostate adenocarcinoma and an epithelial-to-mesenchymal transition. Cancer Cell. 2007;12:559-71 pubmed
    ..iFGFR1 inactivation by CID withdrawal led to full reversion of prostatic intraepithelial neoplasia, whereas PCa lesions became iFGFR1-independent...
  62. Ugolkov A, Eisengart L, Luan C, Yang X. Expression analysis of putative stem cell markers in human benign and malignant prostate. Prostate. 2011;71:18-25 pubmed publisher
    ..To identify potential prostatic stem cells, we analyzed the expression of several potential stem cell markers in benign prostate and prostatic adenocarcinoma...
  63. Han B, Suleman K, Wang L, Siddiqui J, Sercia L, Magi Galluzzi C, et al. ETS gene aberrations in atypical cribriform lesions of the prostate: Implications for the distinction between intraductal carcinoma of the prostate and cribriform high-grade prostatic intraepithelial neoplasia. Am J Surg Pathol. 2010;34:478-85 pubmed publisher
    ..It may represent cribriform "high-grade prostatic intraepithelial neoplasia" (HGPIN) or "intraductal carcinoma of the prostate" (IDC-P), which is almost always ..
  64. Singh P, Nicholson C, Ragavan N, Blades R, Martin F, Matanhelia S. Risk of prostate cancer after detection of isolated high-grade prostatic intraepithelial neoplasia (HGPIN) on extended core needle biopsy: a UK hospital experience. BMC Urol. 2009;9:3 pubmed publisher
    High-grade prostatic intraepithelial neoplasia (HGPIN) is a precursor lesion to prostate cancer (CaP). UK-based studies examining the occurrence of isolated HGPIN and subsequent risk of CaP are lacking...
  65. Shin S, Kim T, Jin F, van Deursen J, Dehm S, Tindall D, et al. Induction of prostatic intraepithelial neoplasia and modulation of androgen receptor by ETS variant 1/ETS-related protein 81. Cancer Res. 2009;69:8102-10 pubmed publisher
    ..Transgenic ETV1 mice developed prostatic intraepithelial neoplasia as well as hyperplasia/neoplasia in seminal vesicles...
  66. Evren S, Dermen A, Lockwood G, Fleshner N, Sweet J. mTOR-RAPTOR and 14-3-3? immunohistochemical expression in high grade prostatic intraepithelial neoplasia and prostatic adenocarcinomas: a tissue microarray study. J Clin Pathol. 2011;64:683-8 pubmed publisher
    ..The correlation of mTOR, RAPTOR and 14-3-3? in high grade prostatic intraepithelial neoplasia (HGPIN) and prostate cancer has not previously been investigated.
  67. Thompson I, Lucia M, Redman M, Darke A, La Rosa F, Parnes H, et al. Finasteride decreases the risk of prostatic intraepithelial neoplasia. J Urol. 2007;178:107-9; discussion 110 pubmed
    High grade prostatic intraepithelial neoplasia is likely a premalignant lesion of the prostate. Decreasing the frequency of high grade PIN may decrease the risk of prostate cancer...
  68. Jonmarker S, Glaessgen A, Culp W, Pisa P, Lewensohn R, Ekman P, et al. Expression of PDX-1 in prostate cancer, prostatic intraepithelial neoplasia and benign prostatic tissue. APMIS. 2008;116:491-8 pubmed
    ..9 months. We separately arrayed benign prostatic tissue, atrophy, high-grade prostatic intraepithelial neoplasia (HGPIN) and PCa from 40 men and also 17 lymph node metastases...
  69. King J, Xu J, Wongvipat J, Hieronymus H, Carver B, Leung D, et al. Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis. Nat Genet. 2009;41:524-6 pubmed publisher
    The TMPRSS2-ERG fusion, present in approximately 50% of prostate cancers, is less common in prostatic intraepithelial neoplasia (PIN), raising questions about whether TMPRSS2-ERG contributes to disease initiation...