signet ring cell carcinoma


Summary: A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.

Top Publications

  1. Fujita K, Sugao H, Gotoh T, Yokomizo S, Itoh Y. Primary signet ring cell carcinoma of the prostate: report and review of 42 cases. Int J Urol. 2004;11:178-81 pubmed
    We report a case of primary signet ring cell carcinoma of the prostate in a 75-year-old man. Serum prostate specific antigen (PSA) level at presentation was 9.3 ng/mL...
  2. Fukasawa T, Shoji T, Gotoh H, Taniwaka K. [A long-term survivor with stage IV gastric cancer due to postoperative weekly paclitaxel and 5'-DFUR combination therapy]. Gan To Kagaku Ryoho. 2006;33:235-8 pubmed
    ..The patient has been recurrence-free for 25 months and remains alive as of 68 months after surgery. The present therapy may thus be effective in the treatment of previously treated Cur C advanced gastric cancer. ..
  3. Fujita Y, Terashima M, Hoshino Y, Ohtani S, Kashimura S, Kanzaki N, et al. Detection of cancer cells disseminated in bone marrow using real-time quantitative RT-PCR of CEA, CK19, and CK20 mRNA in patients with gastric cancer. Gastric Cancer. 2006;9:308-14 pubmed
  4. Chen J, Hsieh P, Chiang J, Yeh C, Tsai W, Tang R, et al. Clinical outcome of signet ring cell carcinoma and mucinous adenocarcinoma of the colon. Chang Gung Med J. 2010;33:51-7 pubmed
    The purpose of this study was to evaluate the clinicopathologic features and prognosis of signet ring cell carcinoma (SCC) and non-SCC mucinous adenocarcinoma (MC) and to compare them with those of nonmucinous adenocarcinoma (NMC) of the ..
  5. Hirasaki S, Suzuki S, Kanzaki H, Fujita K, Matsumura S, Matsumoto E. Minute signet ring cell carcinoma occurring in gastric hyperplastic polyp. World J Gastroenterol. 2007;13:5779-80 pubmed
    We describe a 45-year-old woman with minute signet ring cell carcinoma occurring in a gastric hyperplastic polyp. A biopsy specimen obtained from the gastric hyperplastic polyp revealed signet ring cell carcinoma...
  6. Sentani K, Oue N, Tashiro T, Sakamoto N, Nishisaka T, Fukuhara T, et al. Immunohistochemical staining of Reg IV and claudin-18 is useful in the diagnosis of gastrointestinal signet ring cell carcinoma. Am J Surg Pathol. 2008;32:1182-9 pubmed publisher
    ..In conclusion, Reg IV staining and claudin-18 staining can aid in diagnosis of gastrointestinal SRCC...
  7. Kiyohara T, Kumakiri M, Kouraba S, Tokuriki A, Ansai S. Primary cutaneous signet ring cell carcinoma expressing cytokeratin 20 immunoreactivity. J Am Acad Dermatol. 2006;54:532-6 pubmed
    Primary cutaneous signet ring cell carcinoma (PCSRCC) is a very unusual but distinctive clinicopathologic entity that can simulate metastatic adenocarcinomas...
  8. Yokoyama A, Shi B, Kawai T, Konishi H, Andoh R, Tachikawa H, et al. Muc4 is required for activation of ErbB2 in signet ring carcinoma cell lines. Biochem Biophys Res Commun. 2007;355:200-3 pubmed
    ..These results supply the biochemical backgrounds in recent studies suggesting the contribution of Muc4 in the tumorigenesis...
  9. Acikalin M, Vardareli E, Tel N, Saricam T, Urer S. Erysipelas-like cutaneous metastasis from gastric signet ring cell carcinoma. J Eur Acad Dermatol Venereol. 2005;19:642-3 pubmed

More Information


  1. Ogino S, Brahmandam M, Cantor M, Namgyal C, Kawasaki T, Kirkner G, et al. Distinct molecular features of colorectal carcinoma with signet ring cell component and colorectal carcinoma with mucinous component. Mod Pathol. 2006;19:59-68 pubmed
    b>Signet ring cell carcinoma and mucinous carcinoma are distinct subtypes of colorectal adenocarcinoma...
  2. Kim D, Park Y, Joo J, Ryu S, Kim Y, Kim S, et al. Clinicopathological characteristics of signet ring cell carcinoma of the stomach. ANZ J Surg. 2004;74:1060-4 pubmed
    ..This study compared the clinicopathological features and prognosis of patients with SRC carcinoma with those with non-signet ring cell carcinoma of the stomach (NSRC).
  3. Kunisaki C, Shimada H, Nomura M, Matsuda G, Otsuka Y, Akiyama H. Therapeutic strategy for signet ring cell carcinoma of the stomach. Br J Surg. 2004;91:1319-24 pubmed
    Reports of clinicopathological characteristics and prognosis in patients with signet ring cell carcinoma (SRC) of the stomach are conflicting.
  4. Lee W, Chun H, Lee W, Yun S, Cho Y, Yun H, et al. Treatment outcomes in patients with signet ring cell carcinoma of the colorectum. Am J Surg. 2007;194:294-8 pubmed
    ..The aim of this study was to evaluate the clinicopathologic features and prognosis of signet ring cell (SRC) carcinoma and compare them with those of mucinous and poorly differentiated adenocarcinomas of the colorectum...
  5. Sim H, Tan K, Poon P, Cheng A. Primary rectal signet ring cell carcinoma with peritoneal dissemination and gastric secondaries. World J Gastroenterol. 2008;14:2118-20 pubmed
    ..The overall picture was that of a primary rectal signet ring cell carcinoma with peritoneal dissemination...
  6. Ko Y, Jung C, Oh S, Kim T, Won H, Kang J, et al. Primary signet ring cell carcinoma of the appendix: a rare case report and our 18-year experience. World J Gastroenterol. 2008;14:5763-8 pubmed
    ..5% of all gastrointestinal neoplasms. Moreover, primary signet ring cell carcinoma of the appendix is an exceedingly rare entity...
  7. Sung C, Seo J, Kim K, Do I, Kim S, Park C. Clinical significance of signet-ring cells in colorectal mucinous adenocarcinoma. Mod Pathol. 2008;21:1533-41 pubmed publisher
  8. Schaefer I, Sauer U, Liwocha M, Schorn H, Loertzer H, Fuzesi L. Occult gastric signet ring cell carcinoma presenting as spermatic cord and testicular metastases: "Krukenberg tumor" in a male patient. Pathol Res Pract. 2010;206:519-21 pubmed publisher
    Krukenberg tumor is a well-known ovarian metastasis, usually of gastric signet ring cell carcinoma in female patients...
  9. Ishibashi Y, Ito Y, Omori K, Wakabayashi K. Signet ring cell carcinoma of the ampulla of vater. A case report. JOP. 2009;10:690-3 pubmed
    b>Signet ring cell carcinoma of the ampulla of Vater is extremely rare and only 12 cases have previously been described in the English language literature...
  10. Fang W, Wu C, Lo S, Chen J, Hsieh M, Shen K, et al. Mucin-producing gastric cancer: clinicopathological difference between signet ring cell carcinoma and mucinous carcinoma. Hepatogastroenterology. 2009;56:1227-31 pubmed
    b>Signet ring cell carcinoma and mucinous carcinoma are mucin-producing gastric cancers. Their clinicopathological difference was obscure.
  11. Chua T, Pelz J, Kerscher A, Morris D, Esquivel J. Critical analysis of 33 patients with peritoneal carcinomatosis secondary to colorectal and appendiceal signet ring cell carcinoma. Ann Surg Oncol. 2009;16:2765-70 pubmed publisher
    ..The majority of patients develop peritoneal carcinomatosis (PC) early in the disease. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) may potentially improve survival...
  12. Lee J, Park M, Kim K, Yu J, Kim M, Yang S, et al. Advanced gastric carcinoma with signet ring cell carcinoma versus non-signet ring cell carcinoma: differentiation with multidetector CT. J Comput Assist Tomogr. 2006;30:880-4 pubmed
    ..of multidetector computed tomography (MDCT) to assist in the differentiation of advanced gastric carcinoma with signet ring cell type from that with non-signet ring cell carcinoma (NSRC) with a focus on the thickened stomach wall itself.
  13. Mortensen A, Heegaard S, Clemmensen O, Prause J. Signet ring cell carcinoma of the eyelid - the monocle tumour. APMIS. 2008;116:326-32 pubmed publisher
    We report the clinical and histopathological characteristics of two cases of signet ring cell carcinoma of the eye lids, and discuss the histogenesis of this neoplasm...
  14. Tian M, Zhao A, Li Z, Li J. Phenotypic classification of gastric signet ring cell carcinoma and its relationship with clinicopathologic parameters and prognosis. World J Gastroenterol. 2007;13:3189-98 pubmed
  15. Qureshi S, Shrikhande S, Tanuja S, Shukla P. Breast metastases of gastric signet ring cell carcinoma: a differential diagnosis with primary breast signet ring cell carcinoma. J Postgrad Med. 2005;51:125-7 pubmed
    ..In this report, we present a case of signet ring cell stomach cancer with metastasis to the breast and discuss the differential diagnostic options...
  16. Sakashita N, Yokose C, Fujii K, Matsumoto M, Ohnishi K, Takeya M. Pulmonary tumor thrombotic microangiopathy resulting from metastatic signet ring cell carcinoma of the stomach. Pathol Int. 2007;57:383-7 pubmed
    ..Herein is reported a case of pulmonary tumor thrombotic microangiopathy associated with gastric signet ring cell carcinoma. A 51-year-old woman with gastric cancer died of subacute respiratory failure...
  17. Biedrzycki O, Arnaout A, Coppen M, Shepherd N. Isolated intramucosal goblet cells in subacute ischaemic enteritis: mimicry of signet ring cell carcinoma. Histopathology. 2005;46:460-2 pubmed
  18. Wagemakers M, Verhagen W, Borne B, Venderink D, Wauters C, Strobbe L. Bilateral profound hearing loss due to meningeal carcinomatosis. J Clin Neurosci. 2005;12:315-8 pubmed
    ..Hearing loss as the presenting symptom of MC is very uncommon. A patient with an esophageal signet ring cell carcinoma 3 years previously presented with sudden onset of profound hearing loss affecting both ears...
  19. Tot T. The role of cytokeratins 20 and 7 and estrogen receptor analysis in separation of metastatic lobular carcinoma of the breast and metastatic signet ring cell carcinoma of the gastrointestinal tract. APMIS. 2000;108:467-72 pubmed
    ..ER identified 31/34 of breast cancer metastases. By combining the results of CK20 and ER staining all the metastases could be properly classified as the CK20+/ER- pattern identified all the gastrointestinal tumors...
  20. Sato C, Naganawa S, Kumada H, Miura S, Ishigaki T. MR imaging of gastric cancer in vitro: accuracy of invasion depth diagnosis. Eur Radiol. 2004;14:1543-9 pubmed
    ..The grading by MR imaging matched the histopathologic findings for all 12 tumors. The overall accuracy was 100%. Thus, MR imaging in vitro was sufficiently accurate for grading cancerous invasion of the gastric wall...
  21. Langel D, Yeatts R, White W. Primary signet ring cell carcinoma of the eyelid: report of a case demonstrating further analogy to lobular carcinoma of the breast with a literature review. Am J Dermatopathol. 2001;23:444-9 pubmed
    Primary signet ring cell carcinoma of the eyelid is a rare neoplasm with less than ten cases described...
  22. Henson D, Dittus C, Younes M, Nguyen H, Albores Saavedra J. Differential trends in the intestinal and diffuse types of gastric carcinoma in the United States, 1973-2000: increase in the signet ring cell type. Arch Pathol Lab Med. 2004;128:765-70 pubmed
    ..This decline has primarily included the intestinal type (Lauren classification). However, there is an impression among pathologists that the diffuse type, especially the signet ring cell subtype, has become more prevalent...
  23. Wang K, Weinrach D, Lal A, Musunuri S, Ramirez J, Ozer O, et al. Signet-ring cell change versus signet-ring cell carcinoma: a comparative analysis. Am J Surg Pathol. 2003;27:1429-33 pubmed
    ..Extensive SCC, although rare, can occur in different clinical conditions and can be easily mistaken for SRCA. When in doubt, routine immunohistochemical stains such as p53, Ki-67, and E-cadherin can help to differentiate SCC from SRCA...
  24. Muta H, Noguchi M, Kanai Y, Ochiai A, Nawata H, Hirohashi S. E-cadherin gene mutations in signet ring cell carcinoma of the stomach. Jpn J Cancer Res. 1996;87:843-8 pubmed
    ..These results indicated that E-cadherin gene mutations are an early event in the development of signet ring cell carcinoma of the stomach...
  25. Cavazzini G, Colpani F, Cantore M, Aitini E, Rabbi C, Taffurelli M, et al. Breast metastasis from gastric signet ring cell carcinoma, mimicking inflammatory carcinoma. A case report. Tumori. 1993;79:450-3 pubmed
    ..Although a primary signet ring cell breast carcinoma were described, the pathologic patterns of the breast lesion, here reported, lead us to conclude this was a metastasis and not another primary tumor...
  26. Wollensak G, Witschel H, Bohm N. Signet ring cell carcinoma of the eccrine sweat glands in the eyelid. Ophthalmology. 1996;103:1788-93 pubmed
    b>Signet ring cell carcinoma of the eyelid is a rare variant of eccrine sweat gland carcinoma and has been reported previously in only five patients.
  27. Yokota T, Kunii Y, Teshima S, Yamada Y, Saito T, Kikuchi S, et al. Signet ring cell carcinoma of the stomach: a clinicopathological comparison with the other histological types. Tohoku J Exp Med. 1998;186:121-30 pubmed
    A retrospective analysis was carried out on 93 patients with signet ring cell carcinoma of the stomach operated on between 1985 and 1995, to review the clinicopathologic characteristics from the database of gastric cancer at Sendai ..
  28. FB F, Hofman V, Lagier J, Gastaud P, Santini J, Hofman P. [Primary signet ring cell carcinoma of the eccrine sweat gland in the eyelid. Immunohistochemical and ultrastructural study of a case]. J Fr Ophtalmol. 2002;25:547-51 pubmed
    ..Differential diagnosis with a metastasis from a mammary adenocarcinoma is difficult and a complete staging is necessary to confirm the primitive origin of the tumor. The behavior of this tumor is marked by locoregional recurrence...
  29. Abe N, Watanabe T, Sugiyama M, Yanagida O, Masaki T, Mori T, et al. Endoscopic treatment or surgery for undifferentiated early gastric cancer?. Am J Surg. 2004;188:181-4 pubmed
    ..This study was conducted to determine this subgroup among undifferentiated EGC patients in whom the risk of LNM can be highly ruled out in an attempt to identify candidates who can be treated by EMR...
  30. Michal M, Chlumska A, Mukensnabl P. Signet-ring cell aggregates simulating carcinoma in colon and gallbladder mucosa. Pathol Res Pract. 1998;194:197-200 pubmed
    ..The occurrence of benign signet-ring cell aggregates is a rare and very misleading diagnostic pitfall which must be differentiated from signet-ring cell carcinoma of the colon and gallbladder...
  31. González Lois C, Rodriguez Peralto J, Serrano Pardo R, Martinez Gonzalez M, Lopez Rios F. Cutaneous signet ring cell carcinoma: a report of a case and review of the literature. Am J Dermatopathol. 2001;23:325-8 pubmed
    ..We report a case of CSRCC in a 70-year-old man along with its histologic and ultrastructural characteristics, and review of previous cases. We describe their main diagnostic features and discuss its wide differential diagnosis...
  32. Mai K, Isotalo P, Guindi M, Burns B, Parks W. Intestinal epithelial lesions associated with signet ring cell carcinoma of the colon and small intestine. Pathology. 2002;34:51-6 pubmed
    The purpose of this study was to investigate the epithelial lesions associated with signet ring cell carcinoma (SRCC) of the colon and small intestine and the possible mechanism of tumour development.
  33. Hirano Y, Suzuki K, Fujita K, Furuse H, Fukuta K, Kitagawa M, et al. Primary signet ring cell carcinoma of the urinary bladder successfully treated with intra-arterial chemotherapy alone. Urology. 2002;59:601 pubmed
    ..Cystoscopy revealed a sessile tumor on the left bladder wall. It was diagnosed as primary signet ring cell carcinoma of the bladder (T3bN0M0). The patient did not want surgical treatment...
  34. Bodi I, Andrews T, Howard R, Al Sarraj S. Carcinomatous meningitis from primary signet ring cell carcinoma of bladder. Histopathology. 2004;44:394-6 pubmed
  35. Charlton A, Blair V, Shaw D, Parry S, Guilford P, Martin I. Hereditary diffuse gastric cancer: predominance of multiple foci of signet ring cell carcinoma in distal stomach and transitional zone. Gut. 2004;53:814-20 pubmed
    ..While two recent series of prophylactic gastrectomy described microscopic foci of signet ring cell carcinoma in sample sections from 10 macroscopically normal stomachs, whole stomach phenotype has not been mapped...
  36. Shimoyama S, Seto Y, Aoki F, Ogawa T, Toma T, Endo H, et al. Gastric cancer with metastasis to the gingiva. J Gastroenterol Hepatol. 2004;19:831-5 pubmed
    ..Hematogenous spread could be a mechanism of metastasis for this unusual tumor...
  37. Bouquot M, Dokmak S, Barbier L, Cros J, Levy P, Sauvanet A. Gastric stump carcinoma as a long-term complication of pancreaticoduodenectomy: report of two cases and review of the English literature. BMC Gastroenterol. 2017;17:117 pubmed publisher
    ..Its incidence might increase in the future due to prolonged survival observed after pancreaticoduodenectomy for benign and premalignant lesions. ..
  38. Hasegawa S, Yoshikawa T, Yoshida T, Osaragi T, Cho H, Tsuburaya A, et al. [A case of breast metastasis of gastric cancer]. Gan To Kagaku Ryoho. 2007;34:1115-8 pubmed
    ..In Japan, there are 25 reports of breast metastasis from gastric cancer. Two possible pathways from gastric lesion were lymphatic and one vascular, but the mechanism of breast metastasis has remained controversial. ..
  39. Purohit R, Kant K, Bhargava N, Kothari N, Purohit V. Signet ring cell carcinoma of ampulla of Vater in a young adult. Indian J Gastroenterol. 2005;24:222-3 pubmed
    b>Signet ring cell carcinoma of the ampulla of Vater is extremely rare. The 7 cases reported earlier have been in older patients...
  40. Ragazzi M, Carbonara C, Rosai J. Nonneoplastic signet-ring cells in the gallbladder and uterine cervix. A potential source of overdiagnosis. Hum Pathol. 2009;40:326-31 pubmed publisher
    ..Awareness of this phenomenon is of importance to avoid a potential overdiagnosis of signet-ring cell adenocarcinoma. ..
  41. Morelli O, Castellani D, Asciutti S, Baldoni M, Familiari L, Nardi E, et al. Colon and gastric metastases from a primary signet-ring cell carcinoma of the urinary bladder. Dig Liver Dis. 2006;38:609-11 pubmed
    ..Eighteen months after radical cystectomy, the patient developed colon and stomach metastases. This case represents the first description of a primary signet-ring cell carcinoma of the urinary bladder with gastrointestinal metastases. ..
  42. Park J, Lee Y, Kim J, Kim Y, Lee S, Shin S, et al. Clinicopathological features and prognostic factors of proximal gastric carcinoma in a population with high Helicobacter pylori prevalence: a single-center, large-volume study in Korea. Ann Surg Oncol. 2010;17:829-37 pubmed publisher
    ..PGC is often diagnosed at more advanced stage than other gastric cancers, and therefore early detection is critical for successful treatment. ..
  43. Zhao Z, Ru G, Ma J. [mRNA expression of IGF-IIand HGF in relation to microvascular density, tumor progression and prognosis of gastric carcinoma]. Zhonghua Zhong Liu Za Zhi. 2004;26:673-7 pubmed
    ..5. IGF-II and HGF promote angiogenesis in gastric cancer, and take part in tumor invasion and metastasis. They can be used as prognostic markers of gastric cancer in clinical practice. ..
  44. Tsuji T, Iwahashi M, Nakamori M, Ueda K, Ishida K, Naka T, et al. Multiple early gastric cancer with gastritis cystica profunda showing various histological types. Hepatogastroenterology. 2008;55:1150-2 pubmed
    ..moderately differentiated, poorly differentiated adenocarcinoma, mucinous adenocarcinoma and signet ring cell carcinoma- that had developed independently in the mucosal and submucosal layers of the resected specimen...
  45. Zhang J, Xiao Y, Lu M, Li J, Zhang X, Li Y, et al. [Retrospective study on regimens of capecitabine-based chemotherapy in the treatment for advanced gastric cancer]. Zhonghua Zhong Liu Za Zhi. 2009;31:312-5 pubmed
    ..The regimen of capecitabine combined with paclitaxel was more effective than other regimens. However, further investigation to improve it is still required. ..
  46. Yie S, Yang H, Ye S, Li K, Dong D, Lin X. Expression of human leukocyte antigen G (HLA-G) correlates with poor prognosis in gastric carcinoma. Ann Surg Oncol. 2007;14:2721-9 pubmed
    ..44-24.0). Overall, our results indicated that the expression of HLA-G is a characteristic feature of gastric carcinoma and that immunostaining by anti-HLA-G antibody may be a potentially useful prognostic indicator. ..
  47. Shida A, Fujioka S, Kobayashi K, Ishibashi Y, Omura N, Mitsumori N, et al. Pre-pyloric site gastric cancer after pylorus-preserving gastrectomy (PPG): a case report. Int J Surg. 2008;6:e20-3 pubmed publisher
    ..We report a patient who developed a pre-pyloric site gastric cancer after PPG. To our knowledge, this is the first report on the development of pre-pyloric site gastric cancer after PPG in the English literature using PubMed. ..
  48. Kuhn E, Manoni S, De Anda J. Images in pathology. Signet ring cells in an endometrial biopsy: tumor or not tumor? That is the question. Int J Surg Pathol. 2006;14:227 pubmed
  49. Reingruber B, Boettcher M, Klein P, Hohenberger W, Pelz J. Hyperthermic intraperitoneal chemoperfusion is an option for treatment of peritoneal carcinomatosis in children. J Pediatr Surg. 2007;42:E17-21 pubmed
    ..Thirty months after HIPEC, he died of progressive recurrent disease. Hyperthermic intraperitoneal chemoperfusion as performed in adults may be beneficial to children with peritoneal carcinomatosis and merits further study. ..
  50. Wachtel M, Zhang Y, Chiriva Internati M, Frezza E. Different regression equations relate age to the incidence of Lauren types 1 and 2 stomach cancer in the SEER database: these equations are unaffected by sex or race. BMC Cancer. 2006;6:65 pubmed
    ..The results should be validated by evaluation of other databases. ..
  51. Ruiz Hernández G, Delgado Bolton R, Rubio Pérez M, Jiménez Vicioso A, Perez Castejon M, Carreras Delgado J. [Recurrent signet-ring cell gastric carcinoma evidenced by FDG-PET]. Rev Esp Med Nucl. 2005;24:326-30 pubmed
    ..In this case report we stress the importance of early recurrence by FDG-PET in a non-intestinal gastric carcinoma. This is of interest given the greater difficulty to detect mucous secreting and/or producing carcinomas with the PET-FDG. ..
  52. Aihara R, Mochiki E, Ohotake S, Kamiyama Y, Ohono T, Kuwano H, et al. Peritoneal recurrence of gastric cancer with mucin phenotype 12 years after curative resection: report of a case. Surg Today. 2007;37:325-9 pubmed
    ..Although peritoneal recurrence so many years after curative gastrectomy is rare, careful long-term follow-up should be done for all patients undergoing surgery for gastric cancer with mucin phenotype. ..
  53. Reichert R. Primary ovarian adenofibromatous neoplasms with mucin-containing signet-ring cells: a report of 2 cases. Int J Gynecol Pathol. 2007;26:165-72 pubmed
  54. Schott M, Sagert C, Willenberg H, Schinner S, Ramp U, Varro A, et al. Carcinogenic hypergastrinemia: signet-ring cell carcinoma in a patient with multiple endocrine neoplasia type 1 with Zollinger-Ellison's syndrome. J Clin Endocrinol Metab. 2007;92:3378-82 pubmed
    ..Mutations in the epithelial cadherin (E-cadherin) gene have been shown to be associated with the occurrence of diffuse gastric carcinomas in affected families...
  55. Zheng H, Xu X, Yu M, Takahashi H, Masuda S, Takano Y. The role of Reg IV gene and its encoding product in gastric carcinogenesis. Hum Pathol. 2010;41:59-69 pubmed publisher
    ..05). Among histologic subtypes of the World Health Organization, signet ring cell carcinoma more frequently expressed Reg IV than the others (P < ...
  56. Konishi H, Kikuchi S, Ochiai T, Ikoma H, Kubota T, Ichikawa D, et al. Latrunculin a has a strong anticancer effect in a peritoneal dissemination model of human gastric cancer in mice. Anticancer Res. 2009;29:2091-7 pubmed
    ..Data indicated that latrunculin A has strong anticancer effects, and it may be a new candidate i.p. drug against peritoneal dissemination of gastric cancer in humans...
  57. Cho H, Kim W, Hur H, Jeon H. Laparoscopy-assisted completion total gastrectomy for gastric cancer in remnant stomach: report of 2 cases. Surg Laparosc Endosc Percutan Tech. 2009;19:e57-60 pubmed publisher
    ..Furthermore, we conducted the curative operations through a sufficiently extended lymphadenectomy or even through the resection of surrounding organs...
  58. Moon K, Cho S, Lee H, Jeon Y, Chung J, Jung K, et al. Distinct expression patterns of E-cadherin and beta-catenin in signet ring cell carcinoma components of primary pulmonary adenocarcinoma. Arch Pathol Lab Med. 2006;130:1320-5 pubmed
    ..Primary signet ring cell carcinoma (SRCC) of the lung is a rare variant of pulmonary adenocarcinoma, and E-cadherin and beta-catenin ..
  59. Fadare O. Pleomorphic lobular carcinoma in situ of the breast composed almost entirely of signet ring cells. Pathol Int. 2006;56:683-7 pubmed
    ..It is concluded that this is an example of a purely signet ring variant of pleomorphic LCIS...
  60. Kodama T, Ishida H, Okino T, Okamoto R, Takahashi H, Hayashi N, et al. [A case report of complete response by TS-1 and paclitaxel combination chemotherapy for advanced gastric cancer]. Gan To Kagaku Ryoho. 2006;33:1159-62 pubmed
    ..The adverse event was alopecia (grade 2), but she could continue the chemotherapy as an outpatient treatment. After completing 5 cycles of chemotherapy, we recognized the primary tumor as an endoscopic complete response...
  61. Zheng H, Zheng Y, Xia P, Xu X, Xing Y, Takahashi H, et al. The pathobiological behaviors and prognosis associated with Japanese gastric adenocarcinomas of pure WHO histological subtypes. Histol Histopathol. 2010;25:445-52 pubmed publisher
    ..cases were well-, poorly-, or moderately-differentiated subtype, whereas the minority were papillary or signet ring cell carcinoma (SRC). Patients with poorly-differentiated or SRC carcinoma were predominantly young and female...
  62. Moran C. Pulmonary adenocarcinoma: the expanding spectrum of histologic variants. Arch Pathol Lab Med. 2006;130:958-62 pubmed
    ..The current review addresses these unusual variants and the importance of recognizing and properly categorizing them to avoid unnecessary additional workup or possible misdiagnosis...
  63. Brackmann S, Andersen S, Aamodt G, Roald B, Langmark F, Clausen O, et al. Two distinct groups of colorectal cancer in inflammatory bowel disease. Inflamm Bowel Dis. 2009;15:9-16 pubmed publisher
    ..The 2 groups probably represent different pathogenetic entities of neoplasia in IBD. This might have consequences for surveillance strategies. ..
  64. Kusakari C, Soda H, Nakamura Y, Yamaguchi H, Kitazaki T, Nakano H, et al. Mediastinal signet-ring cell carcinoma of unknown primary: long-term survival by treatment with S-1, a novel derivative of 5-fluorouracil. Lung Cancer. 2007;56:139-41 pubmed
  65. Park K, Park Y. Tonsillar metastasis of signet-ring cell adenocarcinoma of the colon. Ear Nose Throat J. 2010;89:376-7 pubmed
    ..The manner in which tonsillar metastases evolve is still unknown, but some hypotheses have been proposed, and we briefly review these theories...
  66. Heyne J, Pfleiderer S, Trebing G, Scheele J, Kaiser W. Palliative portal vein stent placement for lymphatic recurrence of gastric cancer. Int J Colorectal Dis. 2005;20:67-71 pubmed
    ..Percutaneous transhepatic stenting of the main portal vein is a rare intervention...
  67. Klarskov L, Bernstein I, Holck S. HNPCC-associated synchronous early-stage signet-ring cell carcinomas of colonic origin. A comparative morphological and immunohistochemical study of an intramucosal and a submucosal example. Virchows Arch. 2009;454:115-24 pubmed publisher
  68. Nomura S, Nakajima A, Ishimine S, Matsuhashi N, Kadowaki T, Kaminishi M. Differential expression of peroxisome proliferator-activated receptor in histologically different human gastric cancer tissues. J Exp Clin Cancer Res. 2006;25:443-8 pubmed
    ..All samples of intestinal metaplasia and most samples of gastric tumors, except for signet ring cell carcinoma, expressed PPARgamma in the epithelial cells...
  69. Del Sordo R, Bellezza G, Colella R, Mameli M, Sidoni A, Cavaliere A. Primary signet-ring cell carcinoma of the urinary bladder: a clinicopathologic and immunohistochemical study of 5 cases. Appl Immunohistochem Mol Morphol. 2009;17:18-22 pubmed publisher
  70. Skoronad V, Berdov B, Mardynskiĭ I, Titova L. [Comparative analysis of long-term results of combined and surgical treatment in gastric cancer]. Vopr Onkol. 2007;53:427-35 pubmed
    ..In other words, early cancer of the stomach and total involvement must be excluded...
  71. Krunic A, Chen H, Lopatka K. Signet-ring cell carcinoma of the gallbladder with skin metastases. Australas J Dermatol. 2007;48:187-9 pubmed
    ..We also briefly discuss other primary and metastatic skin tumours with signet-ring cell morphology...
  72. Bakkelund K, Fossmark R, Nordrum I, Waldum H. Signet ring cells in gastric carcinomas are derived from neuroendocrine cells. J Histochem Cytochem. 2006;54:615-21 pubmed
    ..This finding could have implications for the classification and understanding of gastric carcinogenesis...