mucoepidermoid carcinoma

Summary

Summary: A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)

Top Publications

  1. Liu X, Adams A. Mucoepidermoid carcinoma of the bronchus: a review. Arch Pathol Lab Med. 2007;131:1400-4 pubmed
    Although mucoepidermoid carcinoma of the salivary gland is relatively common, mucoepidermoid carcinoma arising from the mucous glands of the bronchus is rare...
  2. Arslan M, Eroğlu S, Akin I, Akçayöz N, Saka C. [Mucoepidermoid carcinoma of the larynx: a case report]. Kulak Burun Bogaz Ihtis Derg. 2004;12:48-50 pubmed
    b>Mucoepidermoid carcinoma of the larynx is an uncommon malignancy. It is mostly located in the supraglottis. It frequently occurs in middle-aged and elderly men. The treatment is primarily surgical...
  3. Shieh Y, Shiah S, Jeng H, Lee H, Wu C, Chang L. DNA methyltransferase 1 expression and promoter methylation of E-cadherin in mucoepidermoid carcinoma. Cancer. 2005;104:1013-21 pubmed
    Loss of E-cadherin expression is found frequently in many types of human malignancies, including mucoepidermoid carcinoma (MEC)...
  4. Han S, Kim H, Jeon Y, Oh D, Lee S, Kim D, et al. Mucoepidermoid carcinoma of lung: potential target of EGFR-directed treatment. Lung Cancer. 2008;61:30-4 pubmed publisher
    b>Mucoepidermoid carcinoma (MEC) of lung is a rare malignancy of lung which originates from minor salivary glands of tracheobronchial tree...
  5. Choi D, Kim H, Lee K, Lee K, Park C. Mucoepidermoid carcinoma of the liver diagnosed as a liver abscess: report of a case. Surg Today. 2004;34:968-72 pubmed
    b>Mucoepidermoid carcinoma of the liver is a rare variant of cholangiocarcinoma, containing both mucus-secreting glandular cells and squamous cells mixed in nests...
  6. Okabe M, Miyabe S, Nagatsuka H, Terada A, Hanai N, Yokoi M, et al. MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma. Clin Cancer Res. 2006;12:3902-7 pubmed
    b>Mucoepidermoid carcinoma is the most common primary malignancy of the salivary gland...
  7. Achcar R, Nikiforova M, Dacic S, Nicholson A, Yousem S. Mammalian mastermind like 2 11q21 gene rearrangement in bronchopulmonary mucoepidermoid carcinoma. Hum Pathol. 2009;40:854-60 pubmed publisher
    The translocation t(11;19)(q21;p13) results in the gene fusion of mucoepidermoid carcinoma translocated 1-mammalian mastermind like 2 genes that is the major chromosomal abnormality observed in mucoepidermoid carcinomas of salivary glands ..
  8. Dorso L, Risi E, Triau S, Labrut S, Nguyen F, Guigand L, et al. High-grade mucoepidermoid carcinoma of the mandibular salivary gland in a lion (Panthera leo). Vet Pathol. 2008;45:104-8 pubmed publisher
    ..Histologic and immunohistochemical investigations led to a diagnosis of a high-grade mucoepidermoid carcinoma of the mandibular salivary gland...
  9. Bell D, Luna M, Weber R, Kaye F, El Naggar A. CRTC1/MAML2 fusion transcript in Warthin's tumor and mucoepidermoid carcinoma: evidence for a common genetic association. Genes Chromosomes Cancer. 2008;47:309-14 pubmed publisher
    ..its CRTC1/MAML2 fusion transcript have been identified in several examples of both Warthin's tumor and mucoepidermoid carcinoma and are believed to be associated with the development of a subset of these tumors...

More Information

Publications72

  1. Nakayama T, Miyabe S, Okabe M, Sakuma H, Ijichi K, Hasegawa Y, et al. Clinicopathological significance of the CRTC3-MAML2 fusion transcript in mucoepidermoid carcinoma. Mod Pathol. 2009;22:1575-81 pubmed publisher
    b>Mucoepidermoid carcinoma is the most common primary malignancy of the salivary gland. We and others showed that CRTC1-MAML2 gene fusion was associated with favorable clinicopathological tumor features...
  2. Noda T, Higashiyama M, Oda K, Higaki N, Takami K, Okami J, et al. Mucoepidermoid carcinoma of the thymus treated by multimodality therapy: a case report. Ann Thorac Cardiovasc Surg. 2006;12:273-8 pubmed
    A case report of mucoepidermoid carcinoma of the thymus, aggressively treated by multimodality therapy including surgery, radiotherapy, chemothermotherapy, and systemic chemotherapy is presented...
  3. Yamada T, Chiba W, Yasuba H, Shimada T, Kudo M, Hamada K, et al. [Successful treatment of bronchial mucoepidermoid carcinoma by bronchoplasty]. Kyobu Geka. 2005;58:531-6 pubmed
    ..The tumor was diagnosed as mucoepidermoid carcinoma by bronchoscopic biopsy...
  4. Pires F, da Cruz Perez D, de Almeida O, Kowalski L. Estrogen receptor expression in salivary gland mucoepidermoid carcinoma and adenoid cystic carcinoma. Pathol Oncol Res. 2004;10:166-8 pubmed
    ..All cases were negative. These results do not support a role for estrogens in salivary gland mucoepidermoid carcinoma and adenoid cystic carcinoma.
  5. da Cruz Perez D, Pires F, Lopes M, de Almeida O, Kowalski L. Adenoid cystic carcinoma and mucoepidermoid carcinoma of the maxillary sinus: report of a 44-year experience of 25 cases from a single institution. J Oral Maxillofac Surg. 2006;64:1592-7 pubmed
    The aim of this study was to analyze the clinicopathologic characteristics of all cases of adenoid cystic carcinoma (ACC) and mucoepidermoid carcinoma (MEC) arising in the maxillary sinuses treated in a single institution.
  6. Handra Luca A, Bilal H, Bertrand J, Fouret P. Extra-cellular signal-regulated ERK-1/ERK-2 pathway activation in human salivary gland mucoepidermoid carcinoma: association to aggressive tumor behavior and tumor cell proliferation. Am J Pathol. 2003;163:957-67 pubmed
    Information on oncogenetic events accompanying salivary gland mucoepidermoid carcinoma is so far limited. Activation of extracellular signal-regulated kinases ERK-1 and ERK-2 is strongly correlated to cancer...
  7. Cho N, Han H, Soh Y, Son H. Overexpression of cyclooxygenase-2 correlates with cytoplasmic HuR expression in salivary mucoepidermoid carcinoma but not in pleomorphic adenoma. J Oral Pathol Med. 2007;36:297-303 pubmed
    ..HuR is an mRNA-binding protein that controls the stability of certain transcripts including COX-2...
  8. Calis A, Coskun B, Seven H, Sayin I, Basak T. Laryngeal mucoepidermoid carcinoma: report of two cases. Auris Nasus Larynx. 2006;33:211-4 pubmed
    b>Mucoepidermoid carcinoma (MEC) of the larynx is a rare neoplasm, with a review of the literature having disclosed only 83 documented cases...
  9. Macarenco R, Uphoff T, Gilmer H, Jenkins R, Thibodeau S, Lewis J, et al. Salivary gland-type lung carcinomas: an EGFR immunohistochemical, molecular genetic, and mutational analysis study. Mod Pathol. 2008;21:1168-75 pubmed publisher
    ..carcinomas are uncommon neoplasms of the lung, the two most common being adenoid cystic carcinoma and mucoepidermoid carcinoma. Although they usually have an indolent behavior, adenoid cystic carcinomas can be more aggressive, with ..
  10. Alaeddini M, Khalili M, Tirgary F, Etemad Moghadam S. Argyrophilic proteins of nucleolar organizer regions (AgNORs) in salivary gland mucoepidermoid carcinoma and its relation to histological grade. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105:758-62 pubmed publisher
    ..The aim of this study was to assess the cellular proliferation rate of major and minor salivary gland mucoepidermoid carcinomas (MECs) by quantitative analysis of AgNOR and to determine its relation to histopathologic grading...
  11. O Neill I. t(11;19) translocation and CRTC1-MAML2 fusion oncogene in mucoepidermoid carcinoma. Oral Oncol. 2009;45:2-9 pubmed publisher
    b>Mucoepidermoid carcinoma (MEC) is a relatively uncommon carcinoma of variable histology that can involve many tissue types, most commonly major and minor salivary glands and the tracheo-bronchial tree...
  12. Awwad R, Hsu J. Mucoepidermoid carcinoma of the parotid gland: an unusual presentation. Am J Otolaryngol. 2006;27:344-5 pubmed
  13. Luna M. Salivary mucoepidermoid carcinoma: revisited. Adv Anat Pathol. 2006;13:293-307 pubmed
    b>Mucoepidermoid carcinoma (MEC) is a malignant epithelial neoplasm composed of varying proportions of mucous, epidermoid, intermediate, columnar, and clear cells and often demonstrates prominent cystic growth...
  14. Lee C, Hung Y, Lin C, Hung P, Hung H, Shieh Y. Loss of SFRP1 expression is associated with aberrant beta-catenin distribution and tumor progression in mucoepidermoid carcinoma of salivary glands. Ann Surg Oncol. 2010;17:2237-46 pubmed publisher
    Cytoplasmic and nuclear accumulation of beta-catenin in mucoepidermoid carcinoma (MEC) is frequently noted, but the mechanism is unknown.
  15. Wen D, Zhu X, Guan S, Wu Y, Yu L, Wu J. Silencing of CXCR4 inhibits the proliferation, adhesion, chemotaxis and invasion of salivary gland mucoepidermoid carcinoma Mc3 cells in vitro. Oral Oncol. 2008;44:545-54 pubmed
    b>Mucoepidermoid carcinoma is the most common malignant tumor in salivary glands and high-grade mucoepidermoid carcinoma is often accompanied with poor prognosis...
  16. Bhandarkar N, Chan J, Strome M. A rare case of mucoepidermoid carcinoma of the thyroid. Am J Otolaryngol. 2005;26:138-41 pubmed
    The aim of the study was to report a recent case of mucoepidermoid carcinoma (MEC) of the thyroid, review the pertinent literature, and highlight the importance of multimodal treatment in this potentially aggressive malignancy.
  17. Guo X, Sun S, Wang W, Wei F, Yu H, Ma B. Alterations of p16INK4a tumour suppressor gene in mucoepidermoid carcinoma of the salivary glands. Int J Oral Maxillofac Surg. 2007;36:350-3 pubmed
    b>Mucoepidermoid carcinoma (MEC) is common in the salivary glands, but alterations of the p16(INK4a) tumour suppressor gene are largely unknown...
  18. Emerick K, Fabian R, Deschler D. Clinical presentation, management, and outcome of high-grade mucoepidermoid carcinoma of the parotid gland. Otolaryngol Head Neck Surg. 2007;136:783-7 pubmed
    To describe clinical features of high-grade (HG) mucoepidermoid carcinoma (MEC) of the parotid gland and assess clinical outcomes of one surgical management approach...
  19. Chen K. Intraductal carcinoma of the oral cavity. Am J Surg Pathol. 2005;29:279; author reply 279 pubmed
  20. Nguyen L, Black M, Hier M, Chauvin P, Rochon L. HER2/neu and Ki-67 as prognostic indicators in mucoepidermoid carcinoma of salivary glands. J Otolaryngol. 2003;32:328-31 pubmed
    b>Mucoepidermoid carcinoma is the most common salivary gland malignancy, representing up to 30% of all cases...
  21. Magliulo G, Fusconi M, Pulice G. Mucoepidermoid carcinoma of the external auditory canal: case report. Am J Otolaryngol. 2003;24:274-7 pubmed
    This study reports a case of mucoepidermoid carcinoma (MEC) of the external auditory canal, which to date has only been described once in literature...
  22. Giger R, Mhawech P, Marchal F, Lehmann W, Dulguerov P. Mucoepidermoid carcinoma of Stensen's duct: a case report and review of the literature. Head Neck. 2005;27:829-33 pubmed
    b>Mucoepidermoid carcinoma of Stensen's duct is a rare neoplasm, with only five cases reported in the literature.
  23. Dahse R, Kosmehl H. Detection of drug-sensitizing EGFR exon 19 deletion mutations in salivary gland carcinoma. Br J Cancer. 2008;99:90-2 pubmed publisher
    ..By screening salivary gland carcinoma, two drug-sensitizing EGFR exon 19 delE746-A750 mutations were identified in an adenocystic and in a mucoepidermoid carcinoma of the parotid gland.
  24. Weed D, Gomez Fernandez C, Pacheco J, Ruiz J, Hamilton Nelson K, Arnold D, et al. MUC4 and ERBB2 expression in major and minor salivary gland mucoepidermoid carcinoma. Head Neck. 2004;26:353-64 pubmed
    ..This study investigates MUC4 and ErbB2 receptor expression in major and minor salivary gland mucoepidermoid carcinoma and correlates patterns of expression with clinical outcomes.
  25. Nance M, Seethala R, Wang Y, Chiosea S, Myers E, Johnson J, et al. Treatment and survival outcomes based on histologic grading in patients with head and neck mucoepidermoid carcinoma. Cancer. 2008;113:2082-9 pubmed publisher
    Histopathologic grade of mucoepidermoid carcinoma (MEC) is an established predictor of prognosis and affects treatment protocol...
  26. Lee E, Vargas S, Sawicki G, Boyer D, Grant F, Voss S. Mucoepidermoid carcinoma of bronchus in a pediatric patient: (18)F-FDG PET findings. Pediatr Radiol. 2007;37:1278-82 pubmed
    ..Of the primary malignant pulmonary neoplasms arising in childhood, mucoepidermoid carcinoma accounts for approximately 10%...
  27. Ando M, Nakanishi Y, Asai M, Maeshima A, Matsuno Y. Mucoepidermoid carcinoma of the thyroid gland showing marked ciliation suggestive of its pathogenesis. Pathol Int. 2008;58:741-4 pubmed publisher
    b>Mucoepidermoid carcinoma of the thyroid gland is a rare tumor first described by Rhatigan et al. in 1977. Its pathogenesis is still controversial...
  28. Shieh Y, Hung Y, Hsieh C, Chen J, Chou K, Liu S. Tumor-associated macrophage correlated with angiogenesis and progression of mucoepidermoid carcinoma of salivary glands. Ann Surg Oncol. 2009;16:751-60 pubmed publisher
    ..examined the clinicopathologic significance of TAMs and their association with tumor angiogenesis, cell proliferation, and apoptosis in mucoepidermoid carcinoma (MEC). The potential effect of TAMs on cancer cells was also investigated.
  29. Guo S, Cheuk W, Chan J. Pleomorphic adenoma with mucinous and squamous differentiation: a mimicker of mucoepidermoid carcinoma. Int J Surg Pathol. 2009;17:335-7 pubmed publisher
    ..adenoma with foci of squamous and mucinous differentiation can potentially be misdiagnosed as low-grade mucoepidermoid carcinoma. The circumscribed borders of the tumor, gradual merging of mucoepidermoid foci into areas typical of ..
  30. Ishizumi T, Tateishi U, Watanabe S, Maeda T, Arai Y. F-18 FDG PET/CT imaging of low-grade mucoepidermoid carcinoma of the bronchus. Ann Nucl Med. 2007;21:299-302 pubmed
    ..technique for the evaluation of pulmonary lesions; however, to our knowledge, F-18 FDG PET findings in mucoepidermoid carcinoma of the bronchus have been described in only a few cases...
  31. Fuse E, Kamimura M, Takeda Y, Kawaishi M, Kimura S, Niino H, et al. Response of a thymic mucoepidermoid carcinoma to combination chemotherapy with cisplatin and irinotecan: a case report. Lung Cancer. 2008;59:403-6 pubmed
    ..We describe a patient with advanced thymic mucoepidermoid carcinoma who achieved a complete response to combination chemotherapy with cisplatin (Randa) and irinotecan ..
  32. Shang J, Shui Y, Sheng L, Wang K, Hu Q, Wei Q. Epidermal growth factor receptor and human epidermal growth receptor 2 expression in parotid mucoepidermoid carcinoma: possible implications for targeted therapy. Oncol Rep. 2008;19:435-40 pubmed
    ..The HER2 overexpression was only found in 4.3% (2/46) of the primary mucoepidermoid carcinoma and none of the lymph node metastases (0/11)...
  33. Pires F, Azevedo R, Ficarra G, Cardoso A, Carlos R, Kowalski L, et al. Metastatic renal cell carcinoma to the oral cavity and clear cell mucoepidermoid carcinoma: comparative clinicopathologic and immunohistochemical study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109:e22-7 pubmed publisher
    Metastatic clear cell renal cell carcinoma (CCRCC) should be considered in differential diagnosis of intraoral clear cell tumors, including mucoepidermoid carcinoma (MEC).
  34. Tonon G, Modi S, Wu L, Kubo A, Coxon A, Komiya T, et al. t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Nat Genet. 2003;33:208-13 pubmed
    ..This rearrangement fuses exon 1 from a novel gene of unknown function at 19p13, termed mucoepidermoid carcinoma translocated 1 (MECT1), with exons 2-5 of a novel member of the Mastermind-like gene family (MAML2) at ..
  35. Vaos G, Zavras N, Priftis K, Micahil Strantzia C, Antypas G. Bronchotomy in the treatment of a low-grade bronchial mucoepidermoid carcinoma in a child. J Thorac Cardiovasc Surg. 2004;128:782-3 pubmed
  36. Gomes M, Pepe G, Bomanji J, Al Salihi O, Du Y, Gacinovic S, et al. High-grade mucoepidermoid carcinoma of the accessory parotid gland with distant metastases identified by 18F-FDG PET-CT. Pediatr Blood Cancer. 2008;50:395-7 pubmed
    We report a rare case of a metastatic mucoepidermoid carcinoma (MEC) arising from the accessory parotid gland in a 14-year-old male. In the pre-surgical assessment, the MR and CT showed no other abnormalities apart from the primary lesion...
  37. Moran C, Suster S. Primary mucoepidermoid carcinoma of the pleura. A clinicopathologic study of two cases. Am J Clin Pathol. 2003;120:381-5 pubmed
    Two cases of primary mucoepidermoid carcinoma of the pleura are described. The patients are 2 men, 48 and 61 years old. Clinically, both men sought care because of chest pain in the right side and breathing difficulty...
  38. da Silveira E, Veras Barros S, de Amorim R, Queiroz L, Freitas R, de Souza L. Cytokeratin profile in mucoepidermoid carcinoma is not related to its histological grading of malignancy. Exp Mol Pathol. 2006;81:72-6 pubmed
    ..These results suggest that expression profile of these proteins does not reflect the biological behavior of MCE, however, it guides the detection of cellular types and differential diagnosis from other salivary gland tumors...
  39. Yoon J, Ahn S, Kim S, Kim J. Calcifications in a clear cell mucoepidermoid carcinoma of the hard palate. Int J Oral Maxillofac Surg. 2005;34:927-9 pubmed
    ..A case of clear cell mucoepidermoid carcinoma (MEC) of the hard palate with extensive intratumoural calcifications visible on computed tomography (CT) ..
  40. Prgomet D, Bilic M, Bumber Z, Manojlovic S, Katić V. Mucoepidermoid carcinoma of the larynx: report of three cases. J Laryngol Otol. 2003;117:998-1000 pubmed
    b>Mucoepidermoid carcinoma of the larynx is very rare, with only a few individual cases or studies in small patient groups reported in the literature...
  41. Sogut A, Yilmaz O, Yuksel H. A rare cause of persistent atelectasis in childhood: mucoepidermoid carcinoma. Tuberk Toraks. 2008;56:325-8 pubmed
    ..Open lung biopsy revealed a low-grade mucoepidermoid carcinoma. Left lower lung lobectomy was performed. The patient is in good condition 12 months after the operation...
  42. Weinreb I, Seethala R, Perez Ordonez B, Chetty R, Hoschar A, Hunt J. Oncocytic mucoepidermoid carcinoma: clinicopathologic description in a series of 12 cases. Am J Surg Pathol. 2009;33:409-16 pubmed publisher
    b>Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. Oncocytic MEC (OMEC) has been rarely reported with previous cases suggesting they are largely cystic low-grade neoplasms with a favorable prognosis...
  43. Campanella C, Bucchieri F, Ardizzone N, Marino Gammazza A, Montalbano A, Ribbene A, et al. Upon oxidative stress, the antiapoptotic Hsp60/procaspase-3 complex persists in mucoepidermoid carcinoma cells. Eur J Histochem. 2008;52:221-8 pubmed
    ..NCI-H292 (mucoepidermoid carcinoma) cells were exposed to various concentrations of hydrogen peroxide (H2O2) for 24 hours...
  44. Shilo K, Foss R, Franks T, DePeralta Venturina M, Travis W. Pulmonary mucoepidermoid carcinoma with prominent tumor-associated lymphoid proliferation. Am J Surg Pathol. 2005;29:407-11 pubmed
    We report 6 cases of low-grade pulmonary mucoepidermoid carcinoma displaying a striking lymphoplasmacytic infiltrate...
  45. Chiosea S, Barnes E, Lai S, Egloff A, Sargent R, Hunt J, et al. Mucoepidermoid carcinoma of upper aerodigestive tract: clinicopathologic study of 78 cases with immunohistochemical analysis of Dicer expression. Virchows Arch. 2008;452:629-35 pubmed publisher
    ..We review our experience with mucoepidermoid carcinoma (MEC) and characterize the prognostic value of Dicer expression...
  46. Camelo Piragua S, Habib C, Kanumuri P, Lago C, Mason H, Otis C. Mucoepidermoid carcinoma of the breast shares cytogenetic abnormality with mucoepidermoid carcinoma of the salivary gland: a case report with molecular analysis and review of the literature. Hum Pathol. 2009;40:887-92 pubmed publisher
    b>Mucoepidermoid carcinoma of the breast is a rare entity with specific morphologic and immunohistochemical features similar to its salivary gland counterpart...
  47. Shivapathasundharam B, Bertin A. Clear cell variant of mucoepidermoid carcinoma. Report of a case and a review of clear cell lesions of the oral cavity. Indian J Dent Res. 2003;14:23-8 pubmed
  48. Monoo K, Sageshima M, Ito E, Nishihira S, Ishikawa K. [Histopathological grading and clinical features of patients with mucoepidermoid carcinoma of the salivary glands]. Nihon Jibiinkoka Gakkai Kaiho. 2003;106:192-8 pubmed
    ..and February 2001, we treated 16 patients--10 men and 6 women aged 10-80 years (mean: 44 years)--with mucoepidermoid carcinoma (MEC) of the salivary gland, evaluating them clinically and histopathologically...
  49. Kim Y, Chae S, Jung H. Mucoepidermoid carcinoma arising from the eustachian tube and middle ear. J Laryngol Otol. 2003;117:202-4 pubmed
    We report a case of mucoepidermoid carcinoma (MEC) originating from the eustachian tube and middle ear...
  50. Kang H, Park Y, Kim S, Sohn K, Yoo N, Park J, et al. Double primary mucoepidermoid carcinoma and hepatocellular carcinoma of the liver--a case report. Hepatogastroenterology. 2003;50:238-41 pubmed
    ..case has previously been reported in the literature, although there have been about 14 cases of primary mucoepidermoid carcinoma of the liver. Most of the reported hepatic mucoepidermoid carcinoma showed a poor prognosis...
  51. Li C, Huang S, Li H. Bronchoscopic Nd-YAG laser surgery for tracheobronchial mucoepidermoid carcinoma--a report of two cases. Int J Clin Pract. 2004;58:979-82 pubmed
    b>Mucoepidermoid carcinoma (MEC) of the tracheobronchial tree represents 0.2% of all lung tumours...
  52. Rutigliano D, Meyers P, Ghossein R, Carlson D, Kayton M, Kraus D, et al. Mucoepidermoid carcinoma as a secondary malignancy in pediatric sarcoma. J Pediatr Surg. 2007;42:E9-13 pubmed
    ..Herein we report on 2 patients with sarcoma who developed a case of secondary mucoepidermoid carcinoma after chemotherapy treatment without associated radiation therapy...
  53. Handra Luca A, Lamas G, Bertrand J, Fouret P. MUC1, MUC2, MUC4, and MUC5AC expression in salivary gland mucoepidermoid carcinoma: diagnostic and prognostic implications. Am J Surg Pathol. 2005;29:881-9 pubmed
    We determined whether immunostaining for mucins could provide a better characterization of salivary gland mucoepidermoid carcinoma (MEC). We investigated 63 MECs by immunohistochemistry for MUC1, MUC2, MUC4, and MUC5AC...
  54. Pires F, Chen S, da Cruz Perez D, de Almeida O, Kowalski L. Cytokeratin expression in central mucoepidermoid carcinoma and glandular odontogenic cyst. Oral Oncol. 2004;40:545-51 pubmed
    Central mucoepidermoid carcinoma (MEC) is an entity whose origin is still controversial. Glandular odontogenic cyst (GOC) is a recently described lesion whose relationship to low-grade central MEC has been reported in the literature...
  55. Pires F, de Almeida O, de Araujo V, Kowalski L. Prognostic factors in head and neck mucoepidermoid carcinoma. Arch Otolaryngol Head Neck Surg. 2004;130:174-80 pubmed
    To analyze clinical, histological, and immunohistochemical prognostic factors in a large series of patients with mucoepidermoid carcinoma (MEC) treated in a single institution, using univariate and multivariate survival analyses.
  56. Kim G, Kim H, Oh J, Jo H, Juhng S. Mucoepidermoid carcinoma of the thymus: a case report. J Korean Med Sci. 2004;19:601-3 pubmed
    b>Mucoepidermoid carcinoma of the thymus is an extremely rare malignant mediastinal neoplasm, and to our knowledge, only 13 cases have been reported...
  57. Moller E, Stenman G, Mandahl N, Hamberg H, Mölne L, van den Oord J, et al. POU5F1, encoding a key regulator of stem cell pluripotency, is fused to EWSR1 in hidradenoma of the skin and mucoepidermoid carcinoma of the salivary glands. J Pathol. 2008;215:78-86 pubmed publisher
    ..we report the fusion of EWSR1 and POU5F1 in two types of epithelial tumours: hidradenoma of the skin and mucoepidermoid carcinoma of the salivary glands...
  58. Siddiqui N, Wu S. Fine-needle aspiration biopsy of cystic pleomorphic adenoma with adnexa-like differentiation mimicking mucoepidermoid carcinoma: a case report. Diagn Cytopathol. 2005;32:229-32 pubmed
    ..cystic changes or squamous, mucinous, or sebaceous metaplasia can lead to a false positive diagnosis of mucoepidermoid carcinoma (MEC)...
  59. Fehr A, Röser K, Heidorn K, Hallas C, Löning T, Bullerdiek J. A new type of MAML2 fusion in mucoepidermoid carcinoma. Genes Chromosomes Cancer. 2008;47:203-6 pubmed
    The present study reports for the first time a CRTC3-MAML2 fusion gene in a mucoepidermoid carcinoma, as determined by RT-PCR and sequencing...
  60. Aro K, Leivo I, Makitie A. Management and outcome of patients with mucoepidermoid carcinoma of major salivary gland origin: a single institution's 30-year experience. Laryngoscope. 2008;118:258-62 pubmed
    b>Mucoepidermoid carcinoma (MEC) is one of the most frequent epithelial malignancies of the salivary glands. Prediction of clinical outcome of MEC is challenging.
  61. Luo X, Sun M, Lu C, Zhou Z. The role of Schwann cell differentiation in perineural invasion of adenoid cystic and mucoepidermoid carcinoma of the salivary glands. Int J Oral Maxillofac Surg. 2006;35:733-9 pubmed
    Twenty cases of adenoid cystic carcinoma (ACC) and 18 cases of mucoepidermoid carcinoma (MEC), were examined for expression of the Schwann cell markers S100 protein and glial fibrillary acidic protein (GFAP) by immunohistochemical ..
  62. Leong S, Pinder E, Sasae R, Mortimore S. Mucoepidermoid carcinoma of the tongue. Singapore Med J. 2007;48:e272-4 pubmed
    We report a 27-year-old Congolese man with mucoepidermoid carcinoma (MEC) of the tongue base, which presented as spontaneous intraoral bleeding. Optimal treatment of tongue base MEC is unknown...
  63. Bared A, Dave S, Garcia M, Angeli S. Mucoepidermoid carcinoma of the external auditory canal (EAC). Acta Otolaryngol. 2007;127:280-4 pubmed
    We present the third case of mucoepidermoid carcinoma of the external auditory canal (EAC) in the English literature, and discuss the management of this lesion...