endometrioid carcinoma

Summary

Summary: An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.

Top Publications

  1. Umezu T, Kajiyama H, Terauchi M, Shibata K, Ino K, Nawa A, et al. Establishment of a new cell line of endometrioid carcinoma of the ovary and its chemosensitivity. Hum Cell. 2007;20:71-6 pubmed
    A new cell line (NOE) of human ovarian endometrioid carcinoma was established and characterized. The cell line showed a short spindle-shaped morphology and continued to grow for more than 4 months without contact inhibition...
  2. Uharcek P. Prognostic factors in endometrial carcinoma. J Obstet Gynaecol Res. 2008;34:776-83 pubmed
    ..Other factors currently being investigated are estrogen and progesterone receptor status, p53 status, flow cytometric analysis for ploidy and S-phase fraction, and oncogenes such as HER-2/neu (c-erbB-2)...
  3. Kabukcuoglu S, Oner U, Ozalp S, Dundar E, Yalcin O, Colak E. Prognostic significance of fascin expression in endometrioid carcinoma. Eur J Gynaecol Oncol. 2006;27:481-6 pubmed
    ..Actin bundling protein fascin has been previously associated with tumor progression in human cancers. We evaluated whether fascin also plays a role in endometrioid carcinomas...
  4. Ferrero J, Weber B, Geay J, Lepille D, Orfeuvre H, Combe M, et al. Second-line chemotherapy with pegylated liposomal doxorubicin and carboplatin is highly effective in patients with advanced ovarian cancer in late relapse: a GINECO phase II trial. Ann Oncol. 2007;18:263-8 pubmed
    ..Pegylated liposomal doxorubicin (PLD) has significant single-agent activity in this setting. Therefore, we evaluated the use of PLD plus carboplatin in this patient population...
  5. Madore J, Ren F, Filali Mouhim A, Sanchez L, Köbel M, Tonin P, et al. Characterization of the molecular differences between ovarian endometrioid carcinoma and ovarian serous carcinoma. J Pathol. 2010;220:392-400 pubmed publisher
    ..carcinomas, or whether a significant number of high-grade serous carcinomas have been misclassified as endometrioid carcinoma. Several genetic aberrations are reported to occur in EOCs...
  6. Slater M, Cooper M, Murphy C. The cytoskeletal proteins alpha-actinin, Ezrin, and talin are De-expressed in endometriosis and endometrioid carcinoma compared with normal uterine epithelium. Appl Immunohistochem Mol Morphol. 2007;15:170-4 pubmed
    ..tissue, we found that alpha-actinin and talin were completely de-expressed in both endometriosis and endometrioid carcinoma tissue...
  7. Tsurumaki Y, Kume H, Homma Y. Late recurrence of uterine endometrioid carcinoma in the upper urinary tract. Arch Gynecol Obstet. 2009;280:631-2 pubmed publisher
    We will present an unusual case of endometrioid carcinoma that recurred in the upper urinary tract, showing an intraluminal spread, 11 years after hysterectomy for uterine corpus cancer...
  8. Miyakuni Y, Matsumoto T, Arakawa A, Sonoue H, Suzuki C, Takeda S. Lymphatic invasion according to D2-40 immunostaining is a predictor of nodal metastasis in endometrioid adenocarcinoma of the uterine corpus. Pathol Int. 2008;58:471-6 pubmed publisher
    ..In conclusion, lymphatic invasion demonstrated on D2-40 immunostaining is very useful as a predictor for nodal metastasis in endometrioid adenocarcinoma of uterine corpus...
  9. Merritt M, Green A, Nagle C, Webb P. Talcum powder, chronic pelvic inflammation and NSAIDs in relation to risk of epithelial ovarian cancer. Int J Cancer. 2008;122:170-6 pubmed
    ..We conclude that on balance chronic inflammation does not play a major role in the development of ovarian cancer...

More Information

Publications85

  1. Chakravarty D, Srinivasan R, Ghosh S, Rajwanshi A, Gopalan S. Estrogen receptor beta (ERbeta) in endometrial simple hyperplasia and endometrioid carcinoma. Appl Immunohistochem Mol Morphol. 2008;16:535-42 pubmed publisher
    The aim of this study was to analyze the expression of estrogen receptor (ER) beta in endometrioid carcinoma in comparison to non-neoplastic endometrium.
  2. Torng P, Lee Y, Huang C, Ye J, Lin Y, Chu Y, et al. Insulin-like growth factor binding protein-3 (IGFBP-3) acts as an invasion-metastasis suppressor in ovarian endometrioid carcinoma. Oncogene. 2008;27:2137-47 pubmed
    ..the molecular signature in ovarian cancer invasion, we established and characterized a human ovarian endometrioid carcinoma (EC) cell line OVTW59-P0 and its invasion-related sublines (P1-P4, in the order of increasing invasive ..
  3. Razzouk K, Roman H, Chanavaz Lacheray I, Scotte M, Verspyck E, Marpeau L. Mixed clear cell and endometrioid carcinoma arising in parietal endometriosis. Gynecol Obstet Invest. 2007;63:140-2 pubmed
    We report a case of a mixed clear cell and endometrioid carcinoma arising in parietal endometriosis.
  4. Chang S, Wang T, Tsai C, Hu T, Chang M, Wang H. Increased epithelial stem cell traits in advanced endometrial endometrioid carcinoma. BMC Genomics. 2009;10:613 pubmed publisher
    ..It is unclear, however, whether genes enriched in EpiSCs also contribute in tumor malignancy. Endometrial endometrioid carcinoma (EEC) is a dominant type of the endometrial cancers and is still among the most common female cancers...
  5. Shaco Levy R, Sharabi S, Piura B, Sion Vardy N. MMP-2, TIMP-1, E-cadherin, and beta-catenin expression in endometrial serous carcinoma compared with low-grade endometrial endometrioid carcinoma and proliferative endometrium. Acta Obstet Gynecol Scand. 2008;87:868-74 pubmed publisher
    To investigate the expression of MMP-2, TIMP-1, E-cadherin and beta-catenin in endometrial serous carcinoma (ESC), low-grade endometrial endometrioid carcinoma (EEC), and proliferative endometrium.
  6. Fujimoto T, Nanjyo H, Fukuda J, Nakamura A, Mizunuma H, Yaegashi N, et al. Endometrioid uterine cancer: histopathological risk factors of local and distant recurrence. Gynecol Oncol. 2009;112:342-7 pubmed publisher
    ..To determine the relationship between histopathological prognostic factors and sites of initial recurrence in endometrioid uterine cancer...
  7. Akbulut M, Tosun H, Soysal M, Oztekin O. Endometrioid carcinoma of the endometrium with choriocarcinomatous differentiation: a case report and review of the literature. Arch Gynecol Obstet. 2008;278:79-84 pubmed
    ..An endometrioid adenocarcinoma (EAC) with true trophoblastic differentiation is a rare event with a highly aggressive clinical course...
  8. Mulvany N, Allen D. Combined large cell neuroendocrine and endometrioid carcinoma of the endometrium. Int J Gynecol Pathol. 2008;27:49-57 pubmed
    ..Combined endometrioid and high-grade LCNEC possess more characteristics of a type II than a type I endometrial carcinoma...
  9. Rosen D, Zhang Z, Chang B, Wang X, Lin E, Liu J. Low membranous expression of beta-catenin and high mitotic count predict poor prognosis in endometrioid carcinoma of the ovary. Mod Pathol. 2010;23:113-22 pubmed publisher
    Mutations in the beta-catenin gene are common in ovarian endometrioid carcinoma. Few studies have addressed the association of beta-catenin expression with tumor characteristics and patient outcome, yielding controversial results...
  10. Li S, Chen J, Yang Z, Lu G, Tang H, Hu H. N-myc downstream-regulated gene 1 as a downregulated target gene of PTEN in the controlling of tumourigenesis in endometrioid carcinoma. Indian J Med Res. 2008;127:453-9 pubmed
    ..In this study, we explored the possibility that PTEN alteration may cause carcinogenesis of endometrioid carcinoma by regulating the expression of the NDRG1 gene.
  11. Lee J, Park Y, Choi J, Lee Y, Kim C, Choi C, et al. The expression of the miRNA-200 family in endometrial endometrioid carcinoma. Gynecol Oncol. 2011;120:56-62 pubmed publisher
    ..The purpose of this study was to evaluate the roles of miRNAs as therapeutic targets in human endometrial endometrioid carcinomas (EECs)...
  12. Chakravarty D, Srinivasan R, Ghosh S, Gopalan S, Rajwanshi A, Majumdar S. Estrogen receptor beta1 and the beta2/betacx isoforms in nonneoplastic endometrium and in endometrioid carcinoma. Int J Gynecol Cancer. 2007;17:905-13 pubmed
    ..was to analyze the expression of ERbeta1 and ERbeta2/betacx isoforms in nonneoplastic endometrium and endometrioid carcinoma. The study was conducted on samples of 22 proliferative endometrium, 15 secretory endometrium, 20 simple ..
  13. Torng P, Lin C, Chan M, Yang H, Huang S, Lin C. Promoter methylation of IGFBP-3 and p53 expression in ovarian endometrioid carcinoma. Mol Cancer. 2009;8:120 pubmed publisher
    ..the correlation between IGFBP-3 and p53 expression as well as IGFBP-3 promoter methylation in ovarian endometrioid carcinoma (OEC) by immunohistochemical staining and quantitative methylation-specific PCR (qMSP)...
  14. Torng P, Mao T, Chan W, Huang S, Lin C. Prognostic significance of stromal metalloproteinase-2 in ovarian adenocarcinoma and its relation to carcinoma progression. Gynecol Oncol. 2004;92:559-67 pubmed
    ..MMP-2 expression in ovarian cancer cells has been correlated with poor prognosis. This study attempts to assess the prognostic importance of stromal MMP-2 in patients with ovarian endometrioid and serous adenocarcinoma...
  15. Culton L, Deavers M, Silva E, Liu J, Malpica A. Endometrioid carcinoma simultaneously involving the uterus and the fallopian tube: a clinicopathologic study of 13 cases. Am J Surg Pathol. 2006;30:844-9 pubmed
    ..One fallopian tube carcinoma was mixed with serous carcinoma. In 4 cases, there was also an endometrioid carcinoma involving the ovary, all of them with an intact ovarian capsule...
  16. Wu T, Chang T, Hsueh S, Lai C. Ovarian endometrioid carcinoma with diffuse pigmented peritoneal keratin granulomas: a case report and review of the literature. Int J Gynecol Cancer. 2006;16:426-9 pubmed
    The presence of keratin granulomas in peritoneal cavity associated with ovarian endometrioid carcinoma, which might be related to leakage from the ovarian tumor, is rarely reported...
  17. Chee J, Ho T, Tay E, Low J, Yam K. Endometrioid adenocarcinoma of the uterus: surgico-pathological correlations and role of pelvic lymphadenectomy. Ann Acad Med Singapore. 2003;32:670-5 pubmed
    ..From our study we aim to determine the significance of surgico-pathological parameters of endometrioid carcinoma for pelvic nodal metastases and survival, as well as to study the role of pelvic lymphadenectomy in the ..
  18. Stefansson I, Salvesen H, Immervoll H, Akslen L. Prognostic impact of histological grade and vascular invasion compared with tumour cell proliferation in endometrial carcinoma of endometrioid type. Histopathology. 2004;44:472-9 pubmed
    ..The recently proposed binary architectural grade was also evaluated, in addition to age, depth of myometrial infiltration and FIGO stage in our population-based series of 237 endometrioid carcinomas...
  19. Fersis N, Gruber I, Relakis K, Friedrich M, Becker S, Wallwiener D, et al. Sentinel node identification and intraoperative lymphatic mapping. First results of a pilot study in patients with endometrial cancer. Eur J Gynaecol Oncol. 2004;25:339-42 pubmed
    ..We decided to evaluate sentinel lymph node (SNL) biopsies also in patients with endometrial cancer undergoing hysterectomy with lymphadenectomy...
  20. Lambrou N, Gomez Marin O, Mirhashemi R, Beach H, Salom E, Almeida Parra Z, et al. Optimal surgical cytoreduction in patients with Stage III and Stage IV endometrial carcinoma: a study of morbidity and survival. Gynecol Oncol. 2004;93:653-8 pubmed
    ..To evaluate the survival impact of residual disease at the time of primary surgery for patients with Stage III and IV endometrial carcinoma; to assess morbidity associated with surgical cytoreduction...
  21. Scopa C, Aletra C, Lifschitz Mercer B, Czernobilsky B. Metastases of breast carcinoma to the uterus. Report of two cases, one harboring a primary endometrioid carcinoma, with review of the literature. Gynecol Oncol. 2005;96:543-7 pubmed
    ..The endometrium is even less frequently affected by metastases. Lobular carcinoma is the most common type of breast cancer that metastasizes to the uterus...
  22. Parazzini F, Chiaffarino F, Negri E, Surace M, Benzi G, Franceschi S, et al. Risk factors for different histological types of ovarian cancer. Int J Gynecol Cancer. 2004;14:431-6 pubmed
    ..7) and endometrioid (OR = 0.8) ovarian cancers but not for mucinous (OR = 1.4) and other histologies (OR = 1.6). Finally, our results on dietary fat intake did not show substantial differences in all histological types of ovarian cancer...
  23. Boruta D, Gehrig P, Groben P, Bae Jump V, Boggess J, Fowler W, et al. Uterine serous and grade 3 endometrioid carcinomas: is there a survival difference?. Cancer. 2004;101:2214-21 pubmed
    ..serous carcinoma (USC) with that of women with International Federation of Gynecology and Obstetrics (FIGO) Grade 3 endometrioid carcinoma (G3EC) to determine whether outcomes varied between these two poorly differentiated histologies.
  24. Creasman W, Kohler M, Odicino F, Maisonneuve P, Boyle P. Prognosis of papillary serous, clear cell, and grade 3 stage I carcinoma of the endometrium. Gynecol Oncol. 2004;95:593-6 pubmed
    ..The purpose of this study was to evaluate patients with uterine papillary serous carcinoma (UPSC), clear cell (CC), and grade 3 endometrioid (G3) surgically stage I endometrial cancer...
  25. Santala M, Talvensaari Mattila A. DNA ploidy is an independent prognostic indicator of overall survival in stage I endometrial endometrioid carcinoma. Anticancer Res. 2003;23:5191-6 pubmed
    ..The current retrospective follow-up study aimed to evaluate DNA ploidy, S-phase fraction and preoperative serum CA 125 level as prognostic factors of endometrial endometrioid adenocarcinoma...
  26. Shibata K, Kikkawa F, Suzuki Y, Mizokami Y, Kajiyama H, Ino K, et al. Expression of placental leucine aminopeptidase is associated with a poor outcome in endometrial endometrioid adenocarcinoma. Oncology. 2004;66:288-95 pubmed
    ..This study investigated whether the expression of P-LAP correlates with clinicopathologic factors and prognosis in patients with endometrial endometrioid adenocarcinoma...
  27. Planaguma J, Díaz Fuertes M, Gil Moreno A, Abal M, Monge M, Garcia A, et al. A differential gene expression profile reveals overexpression of RUNX1/AML1 in invasive endometrioid carcinoma. Cancer Res. 2004;64:8846-53 pubmed
    ..types of endometrial carcinoma have been described, based on estrogen relation and grade: endometrioid carcinoma (EEC) and non-EEC (NEEC)...
  28. Kurian A, Balise R, McGuire V, Whittemore A. Histologic types of epithelial ovarian cancer: have they different risk factors?. Gynecol Oncol. 2005;96:520-30 pubmed
    ..The goals of the current study were to characterize further the relation of histologic-specific ovarian cancer risks to reproductive and lifestyle attributes...
  29. Sagae S, Saito T, Satoh M, Ikeda T, Kimura S, Mori M, et al. The reproducibility of a binary tumor grading system for uterine endometrial endometrioid carcinoma, compared with FIGO system and nuclear grading. Oncology. 2004;67:344-50 pubmed
    ..We analyzed this system for predicting the prognosis, with respect to inter- and intraobserver reproducibility and treatment modalities...
  30. Kawate S, Takeyoshi I, Ikota H, Numaga Y, Sunose Y, Morishita Y. Endometrioid adenocarcinoma arising from endometriosis of the mesenterium of the sigmoid colon. Jpn J Clin Oncol. 2005;35:154-7 pubmed
  31. Karahan N, Guney M, Oral B, Kapucuoglu N, Mungan T. CD24 expression is a poor prognostic marker in endometrial carcinoma. Eur J Gynaecol Oncol. 2006;27:500-4 pubmed
    ..CD24 is commonly up-regulated in endometrial cancer and this corroborates the importance of CD24 in tumor progression among these cases. ..
  32. van Wijk F, van der Burg M, Burger C, Vergote I, van Doorn H. Management of recurrent endometrioid endometrial carcinoma: an overview. Int J Gynecol Cancer. 2009;19:314-20 pubmed publisher
    ..The different sites of recurrent disease (ie, local, regional, and/or distant) are evaluated separately; management recommendations are proposed, and alternative approaches are given. ..
  33. Spadaro F, Ramoni C, Mezzanzanica D, Miotti S, Alberti P, Cecchetti S, et al. Phosphatidylcholine-specific phospholipase C activation in epithelial ovarian cancer cells. Cancer Res. 2008;68:6541-9 pubmed publisher
    ..These findings warrant further investigations on the role of PC-PLC and on the effects of its inhibition on the pathways responsible for constitutive EOC cell stimulation and cell proliferation. ..
  34. Berretta R, Merisio C, Piantelli G, Rolla M, Giordano G, Melpignano M, et al. Preoperative transvaginal ultrasonography and intraoperative gross examination for assessing myometrial invasion by endometrial cancer. J Ultrasound Med. 2008;27:349-55 pubmed
  35. Grammatoglou X, Skafida E, Glava C, Katsamagkou E, Delliou E, Vasilakaki T. Synchronous endometrioid carcinoma of the uterine corpus and ovary. A case report and review of the literature. Eur J Gynaecol Oncol. 2009;30:437-9 pubmed
    Synchronous endometrioid carcinoma of the uterine corpus and ovary is an uncommon but well recognized event...
  36. Alexander Sefre F, Nibbs R, Rafferty T, Ayhan A, Singh N, Jacobs I. Clinical value of immunohistochemically detected lymphatic and vascular invasions in clinically staged endometrioid endometrial cancer. Int J Gynecol Cancer. 2009;19:1074-9 pubmed publisher
    ..Lymphatic space invasion detected by using dual immunostaining is of significant value in identifying high-risk patients. ..
  37. Feng W, Marquez R, Lu Z, Liu J, Lu K, Issa J, et al. Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation. Cancer. 2008;112:1489-502 pubmed publisher
    ..Two imprinted genes, paternally expressed 3 (PEG3) and aplasia Ras homologue member I (ARHI), are the most frequently down-regulated in ovarian cancers on gene expression arrays...
  38. Fu C, Li G, Liu F, Lin Q, Fang X. [Effect of carbon dioxide pneumoperitoneum-laparoscopic surgery on tumor seeding and metastases in endometrial cancer]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008;33:130-7 pubmed
    ..No evidence has been found that CO2 pneumoperitoneum-laparoscopic surgery may favor endometrial cancer cell seeding and metastases. ..
  39. Konecny G, Agarwal R, Keeney G, Winterhoff B, Jones M, Mariani A, et al. Claudin-3 and claudin-4 expression in serous papillary, clear-cell, and endometrioid endometrial cancer. Gynecol Oncol. 2008;109:263-9 pubmed publisher
    ..Our aim was to determine the expression pattern and prognostic relevance of claudin-3 and claudin-4 in a large cohort of endometrial cancer patients of diverse histological type and stage...
  40. Navaratnarajah R, Pillay O, Hardiman P. Polycystic ovary syndrome and endometrial cancer. Semin Reprod Med. 2008;26:62-71 pubmed publisher
    ..Potential strategies to prevent endometrial cancer in PCOS women are discussed. ..
  41. Kikuchi R, Tsuda H, Kanai Y, Kasamatsu T, Sengoku K, Hirohashi S, et al. Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer. Cancer Res. 2007;67:7095-105 pubmed
  42. Otsuka I, Uno M, Wakabayashi A, Kameda S, Udagawa H, Kubota T. Predictive factors for prolonged survival in recurrent endometrial carcinoma: Implications for follow-up protocol. Gynecol Oncol. 2010;119:506-10 pubmed publisher
    ..To evaluate the role of follow-up after curative treatment in endometrial carcinoma, we determined predictive factors for prolonged survival after recurrence...
  43. Stanojević Z, Dordević B. [Prognostic parameters in FIGO stage I endometrial carcinoma of endometrioid type]. Vojnosanit Pregl. 2006;63:1006-10 pubmed
    ..b>Endometrioid carcinoma represents about three-fourths of all endometrial carcinoma...
  44. Brustmann H. Poly(ADP-ribose) polymerase (PARP) and DNA-fragmentation factor (DFF45): expression and correlation in normal, hyperplastic and neoplastic endometrial tissues. Pathol Res Pract. 2007;203:65-72 pubmed
    ..45 (DFF45) in normal endometria (NE, n=13), non-atypical (NAH, n=22) and atypical hyperplasia (AH, n=14), endometrioid carcinoma (EC, n=34), serous carcinoma (SC, n=10), and clear cell carcinoma (CCC, n=2)...
  45. Staats P, Clement P, Young R. Primary endometrioid adenocarcinoma of the vagina: a clinicopathologic study of 18 cases. Am J Surg Pathol. 2007;31:1490-501 pubmed
    ..The prognosis seems to be good in low-stage patients, with 11 patients alive and well and 2 alive with recurrent disease. ..
  46. Aparecida Alves C, Silva I, Villanova F, Nicolau S, Custódio M, Bortoletto C, et al. Differential gene expression profile reveals overexpression of MAP3K8 in invasive endometrioid carcinoma. Eur J Gynaecol Oncol. 2006;27:589-93 pubmed
    ..To the best of our knowledge this is the first report showing the MAP3K8 oncogene linked to human endometrial carcinoma suggesting that it may be another molecule involved in human endometrial cancer. ..
  47. Baize N, Mahamat A, Benizri E, Saint Paul M, Mounier N. Bone metastasis from endometrioid ovarian carcinoma: a case study and literature review. Eur J Gynaecol Oncol. 2009;30:326-8 pubmed
    ..In patients suffering from a neoplasm that rarely metastasises to bone, histological proof should be obtained to diagnose uncommon sites of disease relapse. ..
  48. Appel M, Edelweiss M, Fleck J, Rivero L, Rivoire W, Mônego H, et al. P53 and BCL-2 as prognostic markers in endometrial carcinoma. Pathol Oncol Res. 2008;14:23-30 pubmed publisher
    ..On the other hand, BCL-2 expression was not correlated with any known histological factors. ..
  49. Lobo J, Pinto C, Freitas M, Pinheiro M, Vizcaíno R, Oliva E, et al. Ovarian metastasis from uveal melanoma with MLH1/PMS2 protein loss in a patient with germline MLH1 mutated Lynch syndrome: consequence or coincidence?. Virchows Arch. 2017;470:347-352 pubmed publisher
    ..recurred 22 years later presenting as an ovarian metastasis and concurrently a microscopic endometrial endometrioid carcinoma, grade 1/3 was diagnosed...
  50. De Marzi P, Frigerio L, Cipriani S, Parazzini F, Busci L, Carlini L, et al. Adjuvant treatment with concomitant radiotherapy and chemotherapy in high-risk endometrial cancer: a clinical experience. Gynecol Oncol. 2010;116:408-12 pubmed publisher
    ..4% (95% CI, 71.1-95.6). These results, based on a larger series, support our previous data: Paclitaxel plus RT may represent an effective and well-tolerated treatment in high-risk endometrial cancer patients. ..
  51. McCluggage W, Young R. Ovarian sertoli-leydig cell tumors with pseudoendometrioid tubules (pseudoendometrioid sertoli-leydig cell tumors). Am J Surg Pathol. 2007;31:592-7 pubmed
    ..The presence of more typical Sertoli cell elements and Leydig cells, an absence of squamous elements, endometriosis or associated adenofibroma, and the characteristic immunophenotype assist in diagnosis...
  52. Indraccolo U, Cingolani N, Indraccolo S. Bilateral Brenner tumor with endometrial adenocarcinoma in a postmenopausal woman. Eur J Gynaecol Oncol. 2007;28:233-4 pubmed
  53. Gonzalez Bosquet J, Terstriep S, Cliby W, Brown Jones M, Kaur J, Podratz K, et al. The impact of multi-modal therapy on survival for uterine carcinosarcomas. Gynecol Oncol. 2010;116:419-23 pubmed publisher
    ..This highly aggressive uterine malignancy warrants comprehensive surgical staging to assess tumor dissemination followed by systemic therapy in patients with both early and advanced stage disease. ..
  54. McIntosh M, Liu Y, Drescher C, Urban N, Diamandis E. Validation and characterization of human kallikrein 11 as a serum marker for diagnosis of ovarian carcinoma. Clin Cancer Res. 2007;13:4422-8 pubmed
    ..The human kallikrein 11 (hK11) marker has been reported to have favorable predictive value for ovarian cancer, although, by itself, it may be inferior to CA 125...
  55. Saito S, Ito K, Nagase S, Suzuki T, Akahira J, Okamura K, et al. Progesterone receptor isoforms as a prognostic marker in human endometrial carcinoma. Cancer Sci. 2006;97:1308-14 pubmed
    ..0258). The results of our study demonstrated that loss or absence of PR isoform expression determined by immunohistochemistry could become an important prognostic indicator in patients with endometrioid endometrial carcinoma...
  56. Djordjevic B, Clement Kruzel S, Atkinson N, Malpica A. Nodal endosalpingiosis in ovarian serous tumors of low malignant potential with lymph node involvement: a case for a precursor lesion. Am J Surg Pathol. 2010;34:1442-8 pubmed publisher
    ..This result contributes to the understanding of the pathogenesis of extraovarian disease in cases of OSLMP and has important implications for patient management and follow-up...
  57. Shaco Levy R, Piura B. Endometrioid endometrial adenocarcinoma recurring as carcinosarcoma. J Obstet Gynaecol Res. 2008;34:279-82 pubmed publisher
    ..The tumor evolution in this case supports the prevailing opinion that Müllerian carcinosarcomas are derived from carcinomas and represent tumor progression...
  58. Mylonas I. Prognostic significance and clinical importance of estrogen receptor alpha and beta in human endometrioid adenocarcinomas. Oncol Rep. 2010;24:385-93 pubmed
    ..Therefore, the analysis of both estrogen receptors might be used as a marker to identify high-risk patients only in a subset of patients with endometrioid adenocarcinoma...
  59. Chen L, Park S, Tumanov A, Hau A, Sawada K, Feig C, et al. CD95 promotes tumour growth. Nature. 2010;465:492-6 pubmed publisher
    ..These results demonstrate that CD95 has a growth-promoting role during tumorigenesis and indicate that efforts to inhibit its activity rather than to enhance it should be considered during cancer therapy. ..
  60. Briese J, Schulte H, Sajin M, Bamberger C, Redlin K, Milde Langosch K, et al. Correlations between reduced expression of the metastasis suppressor gene KAI-1 and accumulation of p53 in uterine carcinomas and sarcomas. Virchows Arch. 2008;453:89-96 pubmed publisher
    ..In conclusion, KAI-1 and p53 show inverse expression. The reduced KAI-1 expression may be the result of dysregulated p53 function and could be an important step in the endometrial carcinogenesis...
  61. Li B, Li X, Wu L, Zhang W, Li S, Min C, et al. A pilot study of sentinel lymph nodes identification in patients with endometrial cancer. Bull Cancer. 2007;94:E1-4 pubmed
    ..The purpose of this study was to investigate the feasibility of sentinel lymph node (SLN) identification in patients with endometrial cancer...
  62. Razorenova T, Samsonova E, Pozharisskii K, Razorenov G. [Mathematical evaluation of prognostic significance of clinico-morphological and immunohistochemical features of endometrioid adenocarcinoma]. Vopr Onkol. 2007;53:682-9 pubmed
  63. Croog V, Abu Rustum N, Barakat R, Alektiar K. Adjuvant radiation for early stage endometrial cancer with lymphovascular invasion. Gynecol Oncol. 2008;111:49-54 pubmed publisher
    ..To determine the impact of the decrease in use of postoperative pelvic external beam radiation (EBRT) in favor of intravaginal RT (IVRT) alone in patients with early stage endometrial cancer who had lymphovascular invasion (LVI)...
  64. Stolnicu S, Preda O, Dohan M, Puscasiu L, García Galvis O, Nogales F. Pseudoglandular hepatoid differentiation in endometrioid carcinoma of the ovary simulates oxyphilic cell change. Int J Gynecol Pathol. 2008;27:521-5 pubmed publisher
    ..HC) of clear cell and eosinophilic pseudoglandular type that was difficult to differentiate from endometrioid carcinoma of oxyphilic type and sex cord-stromal tumor...
  65. Coosemans A, Moerman P, Verbist G, Maes W, Neven P, Vergote I, et al. Wilms' tumor gene 1 (WT1) in endometrial carcinoma. Gynecol Oncol. 2008;111:502-8 pubmed publisher
    ..To expand the knowledge on the biological role of WT1 in other uterine cancers, we focused on its detection in endometrial carcinoma...
  66. An H, Kim K, Kim J, Shim J, Kang H, Kim T, et al. Microsatellite instability in endometrioid type endometrial adenocarcinoma is associated with poor prognostic indicators. Am J Surg Pathol. 2007;31:846-53 pubmed
    ..03 and 0.05, respectively), known to be the poor prognostic molecular indicators. According to these results, the MSI may represent the poor prognostic impact on the endometrioid type endometrial adenocarcinoma...
  67. Kamat A, Coffey D, Merritt W, Nugent E, Urbauer D, Lin Y, et al. EphA2 overexpression is associated with lack of hormone receptor expression and poor outcome in endometrial cancer. Cancer. 2009;115:2684-92 pubmed publisher
    ..The objective of the current investigation was to study the role of EphA2 in endometrial cancer and its relation to steroid hormone receptor expression...
  68. Smith C, Heeren M, Nicklin J, Perrin L, Land R, Crandon A, et al. Efficacy of routine follow-up in patients with recurrent uterine cancer. Gynecol Oncol. 2007;107:124-9 pubmed
    ..To evaluate the efficacy of routine follow-up in patients with recurrent uterine cancer...
  69. Rasool N, Fader A, Seamon L, Neubauer N, Shahin F, Alexander H, et al. Stage I, grade 3 endometrioid adenocarcinoma of the endometrium: an analysis of clinical outcomes and patterns of recurrence. Gynecol Oncol. 2010;116:10-4 pubmed publisher
    ..To study patterns of recurrence and survival outcomes in patients with surgical stage I, grade 3 endometrioid adenocarcinoma of the endometrium (EA) treated with various treatment modalities...
  70. Pellegrino A, Signorelli M, Fruscio R, Villa A, Buda A, Beretta P, et al. Feasibility and morbidity of total laparoscopic radical hysterectomy with or without pelvic limphadenectomy in obese women with stage I endometrial cancer. Arch Gynecol Obstet. 2009;279:655-60 pubmed publisher
    ..The aim of this study was to describe the feasibility and morbidity rates associated with total laparoscopic radical hysterectomy (TLRH) with or without pelvic lymphadenectomy for stage I endometrial cancer in obese women...
  71. Hidaka T, Kato K, Yonezawa R, Shima T, Nakashima A, Nagira K, et al. Omission of lymphadenectomy is possible for low-risk corpus cancer. Eur J Surg Oncol. 2007;33:86-90 pubmed
    ..The objective of this study is to ascertain whether omission of lymphadenectomy is possible when endometrial cancer is considered low-risk based on intraoperative pathologic indicators...
  72. Agrawal A, Nation J, Ghatage P, Chu P, Ross S, Magliocco A. Malignant chest wall endometriosis: a case report and literature review. J Obstet Gynaecol Can. 2009;31:538-541 pubmed publisher
    ..Most commonly, the pelvic organs are involved. Involvement of the chest wall after hysterectomy is rare. The incidence of malignant transformation is less than 1% for ovarian endometriosis, but is unknown for extraovarian endometriosis...
  73. Xiong Y, Xiong Y, Zhou Y. Expression and significance of beta-catenin, Glut-1 and PTEN in proliferative endometrium, endometrial intraepithelial neoplasia and endometrioid adenocarcinoma. Eur J Gynaecol Oncol. 2010;31:160-4 pubmed
    ..The aim of this study was to explore the potentiality of beta-catenin, Glut-1 and PTEN proteins as markers for a diagnosis of endometrial intraepithelial neoplasia (EIN)...
  74. Zannoni G, Vellone V, Arena V, Prisco M, Scambia G, Carbone A, et al. Does high-grade endometrioid carcinoma (grade 3 FIGO) belong to type I or type II endometrial cancer? A clinical-pathological and immunohistochemical study. Virchows Arch. 2010;457:27-34 pubmed publisher
    ..Further research is needed to clarify the clinical value of this observation...
  75. Mitamura T, Watari H, Todo Y, Koshida T, Sakuragi N. A 14-year-old female patient with FIGO stage IB endometrial carcinoma: a case report. Int J Gynecol Cancer. 2009;19:896-7 pubmed publisher
    ..In addition, no dominant-negative p53 mutation was found by a yeast functional assay. A uterine malignancy should therefore be included in the differential diagnosis in a young female patient complaining of abnormal genital bleeding. ..
  76. Abu Rustum N, Iasonos A, Zhou Q, Oke E, Soslow R, Alektiar K, et al. Is there a therapeutic impact to regional lymphadenectomy in the surgical treatment of endometrial carcinoma?. Am J Obstet Gynecol. 2008;198:457.e1-5; discussion 457.e5-6 pubmed publisher
    ..The objective of the study was to evaluate whether surgical removal of regional lymph nodes influences the overall survival of women with endometrial carcinoma...