adenoid cystic carcinoma

Summary

Summary: Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)

Top Publications

  1. Phuchareon J, Ohta Y, Woo J, Eisele D, Tetsu O. Genetic profiling reveals cross-contamination and misidentification of 6 adenoid cystic carcinoma cell lines: ACC2, ACC3, ACCM, ACCNS, ACCS and CAC2. PLoS ONE. 2009;4:e6040 pubmed publisher
    b>Adenoid cystic carcinoma (ACC) is the second most common malignant neoplasm of the salivary glands. Most patients survive more than 5 years after surgery and postoperative radiation therapy...
  2. Xu Q, Liu X, Cai Y, Yu Y, Chen W. RNAi-mediated ADAM9 gene silencing inhibits metastasis of adenoid cystic carcinoma cells. Tumour Biol. 2010;31:217-24 pubmed publisher
    ..Here, we show that ADAM9 is highly expressed in metastatic cancer tissues and in an adenoid cystic carcinoma cell line with a high metastatic potential...
  3. Suzuki N, Onda T, Yamamoto N, Katakura A, Mizoe J, Shibahara T. Mutation of the p16/CDKN2 gene and loss of heterozygosity in malignant mucosal melanoma and adenoid cystic carcinoma of the head and neck. Int J Oncol. 2007;31:1061-7 pubmed
    ..study was to investigate the molecular biological characteristics of malignant mucosal melanoma (MMM) and adenoid cystic carcinoma (ACC) of the head and neck...
  4. Morais Freitas V, Nogueira da Gama de Souza L, Cyreno Oliveira E, Furuse C, Cavalcanti de Araujo V, Gastaldoni Jaeger R. Malignancy-related 67kDa laminin receptor in adenoid cystic carcinoma. Effect on migration and beta-catenin expression. Oral Oncol. 2007;43:987-98 pubmed
    b>Adenoid cystic carcinoma is a malignant salivary gland neoplasm with recurrence and metastasis. We studied the expression of a malignancy-related non-integrin laminin receptor, the 67LR, in this neoplasm...
  5. De Dosso S, Mazzucchelli L, Ghielmini M, Saletti P. Response to oxaliplatin with cetuximab in minor salivary gland adenoid cystic carcinoma. Tumori. 2009;95:378-81 pubmed
    Esophageal localization of adenoid cystic carcinoma of minor salivary glands is rare; it may occur in the early to mid-sixties' age group and is more frequently encountered in men than women...
  6. Rhee C, Won T, Lee C, Min Y, Sung M, Kim K, et al. Adenoid cystic carcinoma of the sinonasal tract: treatment results. Laryngoscope. 2006;116:982-6 pubmed
    ..Although adenoid cystic carcinoma (ACC) is the second most common cancer occurring in the sinonasal tract, only few studies have been ..
  7. Hara S, Nakashiro K, Goda H, Hamakawa H. Role of Akt isoforms in HGF-induced invasive growth of human salivary gland cancer cells. Biochem Biophys Res Commun. 2008;370:123-8 pubmed publisher
    ..system in the invasive growth of two human salivary gland cancer cell lines: green fluorescent protein-adenoid cystic carcinoma 2 (GFP-ACC2) and GFP-ACCM...
  8. Malhotra K, Agrawal V, Pandey R. High grade transformation in adenoid cystic carcinoma of the parotid: report of a case with cytologic, histologic and immunohistochemical study. Head Neck Pathol. 2009;3:310-4 pubmed publisher
    b>Adenoid cystic carcinoma (ACC) constitutes about 4% of salivary epithelial tumors and is the second common malignant epithelial salivary gland tumor involving both the major and minor salivary glands...
  9. Shi J, Wang S, Zhao E, Shi L, Xu X, Fang M. Paxillin expression levels are correlated with clinical stage and metastasis in salivary adenoid cystic carcinoma. J Oral Pathol Med. 2010;39:548-51 pubmed publisher
    ..the relationship between paxillin expression and clinicopathological features and metastasis in salivary adenoid cystic carcinoma (SACC). A total of 47 SACC were assessed histochemically for paxillin expression...

More Information

Publications80

  1. Seethala R, Hunt J, Baloch Z, LiVolsi V, Leon Barnes E. Adenoid cystic carcinoma with high-grade transformation: a report of 11 cases and a review of the literature. Am J Surg Pathol. 2007;31:1683-94 pubmed
    High-grade transformation of adenoid cystic carcinoma (ACC) (previously referred to as dedifferentiation) is a rare phenomenon that does not fit into the traditional ACC grading schemes...
  2. Vila L, Liu H, Al Quran S, Coco D, Dong H, Liu C. Identification of c-kit gene mutations in primary adenoid cystic carcinoma of the salivary gland. Mod Pathol. 2009;22:1296-302 pubmed publisher
    The CD117 (KIT) protein is overexpressed in many human neoplasms including adenoid cystic carcinoma of salivary glands...
  3. Sasahira T, Oue N, Kirita T, Luo Y, Bhawal U, Fujii K, et al. Reg IV expression is associated with cell growth and prognosis of adenoid cystic carcinoma in the salivary gland. Histopathology. 2008;53:667-75 pubmed publisher
    ..These results suggest that Reg IV might accelerate cell growth and disease progression of ACCs. ..
  4. Hanna E, Vural E, Prokopakis E, Carrau R, Snyderman C, Weissman J. The sensitivity and specificity of high-resolution imaging in evaluating perineural spread of adenoid cystic carcinoma to the skull base. Arch Otolaryngol Head Neck Surg. 2007;133:541-5 pubmed
    To evaluate the sensitivity and specificity of computed tomography (CT) and magnetic resonance imaging (MRI) in detecting perineural spread (PNS) of adenoid cystic carcinoma of the head and neck to the skull base.
  5. Wang H, Xu L, Li F. Subglottic adenoid cystic carcinoma mistaken for asthma. J Zhejiang Univ Sci B. 2009;10:707-10 pubmed publisher
    b>Adenoid cystic carcinoma rarely occurs within the subglottic larynx. In this study, a case of subglottic adenoid cystic carcinoma was reported...
  6. Choi S, Sano D, Cheung M, Zhao M, Jasser S, Ryan A, et al. Vandetanib inhibits growth of adenoid cystic carcinoma in an orthotopic nude mouse model. Clin Cancer Res. 2008;14:5081-9 pubmed publisher
    b>Adenoid cystic carcinoma (ACC) can often be controlled with surgery and postoperative adjuvant radiotherapy but is also characterized by late local recurrence and distant metastasis...
  7. Zhang J, Peng B. NF-kappaB promotes iNOS and VEGF expression in salivary gland adenoid cystic carcinoma cells and enhances endothelial cell motility in vitro. Cell Prolif. 2009;42:150-61 pubmed publisher
    ..and endothelial cell mobility are essential for neovascularization and haematogenous metastasis of adenoid cystic carcinoma (ACC) of the human salivary glands...
  8. Qin M, Fu Y, Yu D, Xu S, Han M, Wang Z. [Diagnosis and treatment of tracheal or bronchuotracheal adenoid cystic carcinoma]. Zhongguo Fei Ai Za Zhi. 2010;13:628-31 pubmed publisher
    b>Adenoid cystic carcinoma is primary bronchopulmonary carcinoma with low malignancy, and 43 patients treated in the past 50 years in our hospital were retrospectively studied...
  9. Dong F, Gidley P, Ho T, Luna M, Ginsberg L, Sturgis E. Adenoid cystic carcinoma of the external auditory canal. Laryngoscope. 2008;118:1591-6 pubmed publisher
    To describe the clinical history and outcome of patients with adenoid cystic carcinoma (ACC) of the external auditory canal (EAC).
  10. He J, Ge M, Zhu X, Chen C, Tan Z, Li Y, et al. Expression of RUNX3 in salivary adenoid cystic carcinoma: implications for tumor progression and prognosis. Cancer Sci. 2008;99:1334-40 pubmed publisher
    ..043). Our results demonstrate the expression of RUNX3 in normal salivary glands and salivary ACCs. The low level of RUNX3 protein in salivary ACCs might play a pivotal role in tumor progression and have prognostic values in ACCs...
  11. da Cruz Perez D, Pires F, Lopes M, de Almeida O, Kowalski L. Adenoid cystic carcinoma and mucoepidermoid carcinoma of the maxillary sinus: report of a 44-year experience of 25 cases from a single institution. J Oral Maxillofac Surg. 2006;64:1592-7 pubmed
    The aim of this study was to analyze the clinicopathologic characteristics of all cases of adenoid cystic carcinoma (ACC) and mucoepidermoid carcinoma (MEC) arising in the maxillary sinuses treated in a single institution.
  12. Rao P, Roberts D, Zhao Y, Bell D, Harris C, Weber R, et al. Deletion of 1p32-p36 is the most frequent genetic change and poor prognostic marker in adenoid cystic carcinoma of the salivary glands. Clin Cancer Res. 2008;14:5181-7 pubmed publisher
    b>Adenoid cystic carcinoma (ACC) is a relatively uncommon salivary gland malignancy known for its protean phenotypic features and pernicious clinical behavior...
  13. Bonaparte J, Hart R, Trites J, Taylor M. Incidence of adenoid cystic carcinoma in nova scotia: 30-year population-based epidemiologic study. J Otolaryngol Head Neck Surg. 2008;37:642-8 pubmed
    b>Adenoid cystic carcinoma (ACC) of the head and neck is a rare malignancy of salivary gland origin. Few epidemiologic studies exist assessing the incidence of this tumour...
  14. Naylor E, Sarkar P, Perlis C, Giri D, Gnepp D, Robinson Bostom L. Primary cutaneous adenoid cystic carcinoma. J Am Acad Dermatol. 2008;58:636-41 pubmed publisher
    Primary cutaneous adenoid cystic carcinoma is a rare, slow-growing malignancy first described by Boggio in 1975...
  15. Aubry M, Heinrich M, Molina J, Lewis J, Yang P, Cassivi S, et al. Primary adenoid cystic carcinoma of the lung: absence of KIT mutations. Cancer. 2007;110:2507-10 pubmed
    ..Adjuvant therapy is often ineffective and identification of a targeted novel therapy would be useful. The objective of the current study was to evaluate KIT expression and KIT-activating mutations...
  16. Luna Ortiz K, Carmona Luna T, Herrera Gomez A, Cano Valdez A. Macroglossia caused by adenoid cystic carcinoma. Case report. Med Oral Patol Oral Cir Bucal. 2008;13:E395-7 pubmed
    ..She had been treated before with tracheostomy and gastrostomy due to an adenoid cystic carcinoma (ACC) of the mobile tongue, in clinical stage IVC...
  17. Agarwal J, Jain S, Gupta T, Tiwari M, Laskar S, Dinshaw K, et al. Intraoral adenoid cystic carcinoma: prognostic factors and outcome. Oral Oncol. 2008;44:986-93 pubmed publisher
    ..To analyze and correlate prognostic factors with outcome in intraoral adenoid cystic carcinoma. Medical records of 76 patients with intraoral adenoid cystic carcinoma treated with definitive loco-..
  18. Petersson F, Kutzner H, Spagnolo D, Bisceglia M, Kacerovska D, Vazmitel M, et al. Adenoid cystic carcinoma-like pattern in spiradenoma and spiradenocylindroma: a rare feature in sporadic neoplasms and those associated with Brooke-Spiegler syndrome. Am J Dermatopathol. 2009;31:642-8 pubmed publisher
    ..We present the rare occurrence of adenoid cystic carcinoma (ACC)-like areas in 7 spiradenomas and 1 spiradenocylindroma, not described in the English literature to ..
  19. Prasad M, Barbacioru C, Rawal Y, Husein O, Wen P. Hierarchical cluster analysis of myoepithelial/basal cell markers in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. Mod Pathol. 2008;21:105-14 pubmed
    Distinguishing adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma of the salivary glands is important for their management...
  20. Huang S, Zhang D, Han J, Zhang N, Zhang S, Mu W, et al. Radiosensitization and anti-tumour effects of cytosine deaminase and thymidine kinase fusion suicide gene in human adenoid cystic carcinoma cells. J Int Med Res. 2009;37:479-90 pubmed
    ..Human adenoid cystic carcinoma (ACC-2) cells transduced with a CD/HSV-TK fusion gene (ACC-2/CD-TK cells) were found to be more sensitive ..
  21. Ross P, Teoh E, A hern R, Rhys Evans P, Harrington K, Nutting C, et al. Epirubicin, cisplatin and protracted venous infusion 5-Fluorouracil chemotherapy for advanced salivary adenoid cystic carcinoma. Clin Oncol (R Coll Radiol). 2009;21:311-4 pubmed publisher
    b>Adenoid cystic carcinoma (ACC) is a rare tumour that usually arises in the salivary glands. Initial management is surgery often combined with adjuvant radiotherapy. Chemotherapy is reserved for treatment of symptomatic recurrence...
  22. Vékony H, Ylstra B, Wilting S, Meijer G, van de Wiel M, Leemans C, et al. DNA copy number gains at loci of growth factors and their receptors in salivary gland adenoid cystic carcinoma. Clin Cancer Res. 2007;13:3133-9 pubmed
    b>Adenoid cystic carcinoma (ACC) is a malignant salivary gland tumor with a high mortality rate due to late, distant metastases. This study aimed at unraveling common genetic abnormalities associated with ACC...
  23. Shimizu J, Oda M, Matsumoto I, Arano Y, Ishikawa N, Minato H. Clinicopathological study of surgically treated cases of tracheobronchial adenoid cystic carcinoma. Gen Thorac Cardiovasc Surg. 2010;58:82-6 pubmed publisher
    Between 1980 and 2007, five patients were pathologically diagnosed as tracheobronchial adenoid cystic carcinoma (ACC). All five patients were women aged 37-67 years...
  24. Youk J, Kim M, Kim E, Lee J, Oh K, Park B. Recurrence of adenoid cystic carcinoma in the breast after lumpectomy and adjuvant therapy. J Ultrasound Med. 2006;25:921-4 pubmed
  25. Zhou C, Gao Y. Aberrant expression of beta-catenin, Pin1 and cylin D1 in salivary adenoid cystic carcinoma: relation to tumor proliferation and metastasis. Oncol Rep. 2006;16:505-11 pubmed
    ..Theses results suggest that Pin1 and Wnt signalling pathway are activated in SACC and may play a pivotal role in SACC carcinogenesis and metastasis...
  26. Dardick I, Daley T, McComb R. Sialoblastoma in adults: distinction from adenoid cystic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109:109-16 pubmed publisher
    ..If even focal cribriforming were present, such cases have undoubtedly been diagnosed as adenoid cystic carcinoma. Such was the circumstance in the 3 adult tumors presented in this report...
  27. Tanaka N, Urabe K, Hashitani S, Sakurai K, Urade M. Establishment and characterization of a human adenoid cystic carcinoma cell line forming colonies cultured in collagen gel and transplantable in nude mice. Oncol Rep. 2007;17:335-40 pubmed
    We established a new cell line (ACCNS) from human adenoid cystic carcinoma (AdCC) of the maxilla, using tissue culture techniques and it has been successfully subcultured for more than 100 passages during 2 years...
  28. Clough A, Clarke P. Adenoid cystic carcinoma of the trachea: a long-term problem. ANZ J Surg. 2006;76:751-3 pubmed
    b>Adenoid cystic carcinoma of the trachea, although rare, is the second most common primary tumour of the trachea...
  29. Carrasco Ortiz D, Aldape Barrios B. Adenoid cystic carcinoma of the dorsum of the tongue: presentation of a case. Med Oral Patol Oral Cir Bucal. 2006;11:E417-20 pubmed
    b>Adenoid cystic carcinoma is the most frequent malignant neoplasm of minor salivary glands (76.5%); it is clinically characterized by slow growth, and its most frequent localization is the hard palate...
  30. Greer R, Said S, Shroyer K, Marileila V, Weed S. Overexpression of cyclin D1 and cortactin is primarily independent of gene amplification in salivary gland adenoid cystic carcinoma. Oral Oncol. 2007;43:735-41 pubmed
    b>Adenoid cystic carcinoma (ACC) of the salivary glands exhibits persistent growth, invasion and metastasis...
  31. Alongi F, Di Muzio N, Motta M, Broggi S, De Martin E, Bolognesi A, et al. Adenoid cystic carcinoma of trachea treated with adjuvant hypofractionated tomotherapy. Case report and literature review. Tumori. 2008;94:121-5 pubmed
    b>Adenoid cystic carcinoma, also called cylindroma, is the second most common histological type of tracheal malignancy but represents 1% of all respiratory tract cancers...
  32. Wang X, Wu D, Li B, Lu Y, Yang B. Synergistic inhibitory effect of sulforaphane and 5-fluorouracil in high and low metastasis cell lines of salivary gland adenoid cystic carcinoma. Phytother Res. 2009;23:303-7 pubmed publisher
    ..and a traditional chemotherapy agent, 5-fluorouracil (5-Fu), against the proliferation of salivary gland adenoid cystic carcinoma high metastatic cell line (ACC-M) and low metastasis cell line (ACC-2)...
  33. Shi H, Wang J, Dong F, Wang X, Li H, Hou Y. The effect of proteoglycans inhibited by RNA interference on metastatic characters of human salivary adenoid cystic carcinoma. BMC Cancer. 2009;9:456 pubmed publisher
    Salivary adenoid cystic carcinoma (SACC) is one of the most common malignancies of salivary gland. Recurrence or/and early metastasis is its biological properties...
  34. Manganaris A, Kiziridou A, Manganaris T. Unusual localization of an adenoid cystic carcinoma subsequent to superficial parotidectomy for a benign lesion. J Craniofac Surg. 2007;18:231-5 pubmed
    b>Adenoid cystic carcinoma of the parotid gland is relatively rare...
  35. Moukarbel R, Goldstein D, O Sullivan B, Gullane P, Brown D, Wang L, et al. Adenoid cystic carcinoma of the larynx: a 40-year experience. Head Neck. 2008;30:919-24 pubmed publisher
    Laryngeal adenoid cystic carcinoma (ACC) is a rare disease. We reviewed our experience at the Princess Margaret Hospital (PMH) with its treatment.
  36. Zhang C, Mao L, Li L, Tian Z, Zhou X, Zhang Z, et al. Promoter methylation as a common mechanism for inactivating E-cadherin in human salivary gland adenoid cystic carcinoma. Cancer. 2007;110:87-95 pubmed
    The role of promoter methylation in the inactivation of E-cadherin (E-cad) in salivary gland adenoid cystic carcinoma (ACC) is unknown...
  37. Nascimento C, Gama de Souza L, Freitas V, Jaeger R. Role of MMP9 on invadopodia formation in cells from adenoid cystic carcinoma. Study by laser scanning confocal microscopy. Microsc Res Tech. 2010;73:99-108 pubmed publisher
    ..Here we characterized invadopodia in a cell line (CAC2) derived from human adenoid cystic carcinoma. We carried out fluorescent-substrate degradation assay to assess in situ protease activity of CAC2 cells...
  38. Hao L, Xiao lin N, Qi C, Yi ping Y, Jia quan L, Yan ning L. Nerve growth factor and vascular endothelial growth factor: retrospective analysis of 63 patients with salivary adenoid cystic carcinoma. Int J Oral Sci. 2010;2:35-44 pubmed publisher
    ..the expression of nerve growth factor (NGF) and vascular endothelial growth factor (VEGF) in salivary adenoid cystic carcinoma (SACC) tissues, as well as to determine the correlation between growth factor expression and prognosis in ..
  39. Zhang S, Wang X, Gan Y, Li S. Activation of c-Jun N-terminal kinase is required for mevastatin-induced apoptosis of salivary adenoid cystic carcinoma cells. Anticancer Drugs. 2010;21:678-86 pubmed
    ..study aims to explore the proapoptotic effects and underlying mechanisms of statins on human salivary adenoid cystic carcinoma (SACC)...
  40. Zvrko E, Golubovic M. Laryngeal adenoid cystic carcinoma. Acta Otorhinolaryngol Ital. 2009;29:279-82 pubmed
    ..b>Adenoid cystic carcinoma is characterised by slow progression, multiple recurrences and late distant metastasis...
  41. Haresh K, Prabhakar R, Rath G, Sharma D, Julka P, Subramani V. Adenoid cystic carcinoma of the trachea treated with PET-CT based intensity modulated radiotherapy. J Thorac Oncol. 2008;3:793-5 pubmed publisher
    Primary tumors of the trachea are rare and are usually malignant in adults and benign in children. Adenoid cystic carcinoma, which is of salivary gland origin, account for about one thirds of adult primary tracheal tumors...
  42. Barnes J, Garcia C. Primary cutaneous adenoid cystic carcinoma: a case report and review of the literature. Cutis. 2008;81:243-6 pubmed
    Primary cutaneous adenoid cystic carcinoma is a rare cancer, with only 61 cases reported in the literature. We report an additional case and review the latest recommendations for workup and treatment.
  43. Seth A, Agarwal A. Adenoid cystic carcinoma of uterine cervix in a young patient. Indian J Pathol Microbiol. 2009;52:543-5 pubmed publisher
    b>Adenoid cystic carcinoma of uterine cervix is a rare tumor. Its origin is debatable. It has a high incidence in postmenopausal women but rarely can develop in patients under 40...
  44. Torrão M, da Costa J, Ferreira E, da Silva M, Paiva I, Lopes C. Adenoid cystic carcinoma of the breast. Breast J. 2007;13:206 pubmed
  45. Daa T, Kashima K, Kondo Y, Yada N, Suzuki M, Yokoyama S. Aberrant methylation in promoter regions of cyclin-dependent kinase inhibitor genes in adenoid cystic carcinoma of the salivary gland. APMIS. 2008;116:21-6 pubmed publisher
    b>Adenoid cystic carcinoma (ACC) is a common malignant neoplasm of the salivary gland. The mechanism underlying ACC carcinogenesis is not fully elucidated, although data on associated genetic alterations are accumulating...
  46. Franceschini G, Terribile D, Scafetta I, Magno S, Fabbri C, Chiesa F, et al. Conservative treatment of a rare case of multifocal adenoid cystic carcinoma of the breast: case report and literature review. Med Sci Monit. 2010;16:CS33-39 pubmed
    b>Adenoid cystic carcinoma of the breast is a rare neoplasm accounting for 0.1% of all malignant breast tumors and presenting most commonly as a painful breast mass...
  47. Bianchi B, Copelli C, Cocchi R, Ferrari S, Pederneschi N, Sesenna E. Adenoid cystic carcinoma of intraoral minor salivary glands. Oral Oncol. 2008;44:1026-31 pubmed publisher
    ..5% at 5 years, 64.9% at 10 years and 61.1% at 15 years. Stage T, cervical lymph node metastasis and surgical margin status proved to make a statistically significant contribution when describing the outcome...
  48. Qing J, Zhang Q, Wei M, Guo Z. [Prognostic analysis of adenoid cystic carcinoma of major salivary glands of 64 cases]. Ai Zheng. 2006;25:1138-43 pubmed
    b>Adenoid cystic carcinoma of salivary glands is a kind of highly malignant tumor, and researches on the tumors originated from major salivary glands are rare...
  49. Unsal A, Karaman C, Kacar F, Sen S. [Atypically located pulmonary adenoid cystic carcinoma: case report]. Tuberk Toraks. 2008;56:210-4 pubmed
    ..a complaint of chronic cough, who was found to have a mass lesion at upper lobe of right lung and a final diagnosis of primary pulmonary adenoid cystic carcinoma according to transbronchial needle biopsy and pneumonectomy, was presented.
  50. Bernheim A, Toujani S, Saulnier P, Robert T, Casiraghi O, Validire P, et al. High-resolution array comparative genomic hybridization analysis of human bronchial and salivary adenoid cystic carcinoma. Lab Invest. 2008;88:464-73 pubmed publisher
    b>Adenoid cystic carcinoma (ACC) is a rare but distinctive tumor. Oligonucleotide array comparative genomic hybridization has been applied for cataloging genomic copy number alterations (CNAs) in 17 frozen salivary or bronchial tumors...
  51. Giannini P, Shetty K, Horan S, Reid W, Litchmore L. Adenoid cystic carcinoma of the buccal vestibule: A case report and review of the literature. Oral Oncol. 2006;42:1029-32 pubmed
    Minor salivary gland tumors of the buccal vestibule are relatively rare. Adenoid cystic carcinoma is the fifth most common salivary gland malignancy following mucoepidermoid carcinoma, adenocarcinoma not otherwise specified (NOS), acinic ..
  52. Zhang J, Peng B. In vitro angiogenesis and expression of nuclear factor kappaB and VEGF in high and low metastasis cell lines of salivary gland Adenoid Cystic Carcinoma. BMC Cancer. 2007;7:95 pubmed
    b>Adenoid cystic carcinoma is a high malignant carcinoma characterized by intensive local invasion and high incidence of distant metastasis...
  53. Yu Y, Chen W, Zhang Y, Hamburger A, Pan H, Zhang Z. Suppression of salivary adenoid cystic carcinoma growth and metastasis by ErbB3 binding protein Ebp1 gene transfer. Int J Cancer. 2007;120:1909-13 pubmed
    ..Matrigel assays demonstrated that the adenoid cystic carcinoma cell invasiveness was significantly reduced...
  54. Garbyal R, Kumar M, Bohra A. Adenoid cystic carcinoma of ceruminous gland: a case report. Indian J Pathol Microbiol. 2006;49:587-9 pubmed
    b>Adenoid cystic carcinoma of the external auditory canal (EAC) is a very rare malignant tumor and its diagnosis is frequently missed because of the superficial nature of biopsies...
  55. Younes M, Park Y, Yazici Y, Gu M, Santillan A, Nong X, et al. Concomitant inhibition of epidermal growth factor and vascular endothelial growth factor receptor tyrosine kinases reduces growth and metastasis of human salivary adenoid cystic carcinoma in an orthotopic nude mouse model. Mol Cancer Ther. 2006;5:2696-705 pubmed
    ..VEGF)-induced angiogenic signals are important for the progression and metastasis of human salivary adenoid cystic carcinoma (ACC)...
  56. Pfeffer M, Talmi Y, Catane R, Symon Z, Yosepovitch A, Levitt M. A phase II study of Imatinib for advanced adenoid cystic carcinoma of head and neck salivary glands. Oral Oncol. 2007;43:33-6 pubmed
    b>Adenoid cystic carcinoma of the salivary glands is characterized by a poor response to chemotherapy. Most cases of adenoid cystic carcinoma express the c-kit protein...
  57. Epivatianos A, Poulopoulos A, Dimitrakopoulos I, Andreadis D, Nomikos A, Vlahou S, et al. Application of alpha-smooth muscle actin and c-kit in the differential diagnosis of adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma. Oral Oncol. 2007;43:67-76 pubmed
    ..The results of this study support the potential application of alpha-SMA and c-kit as an adjunctive aid in the differential diagnosis of AdCCs from PLGAs...
  58. Coates J, Martinez S, Bold R, Chen S. Adjuvant radiation therapy is associated with improved survival for adenoid cystic carcinoma of the breast. J Surg Oncol. 2010;102:342-7 pubmed publisher
    The role of adjuvant radiation therapy (RT) for adenoid cystic carcinoma (ACC) of the breast remains unclear.
  59. Ferrazzo K, Alves S, Santos E, Martins M, de Sousa S. Galectin-3 immunoprofile in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of salivary glands. Oral Oncol. 2007;43:580-5 pubmed
    b>Adenoid cystic carcinoma (ACC) and polymorphous low-grade adenocarcinoma (PLGA) are malignant neoplasms of salivary glands, which are similar in histologic patterns but very different in clinical behavior, treatment and prognosis...
  60. Chikamatsu K, Shino M, Sakakura K, Nakajima K, Sakurai T, Miyashita M, et al. Expression of thymidylate synthase and dihydropyrimidine dehydrogenase in adenoid cystic carcinoma of the head and neck: correlation with clinical outcome. Oral Oncol. 2007;43:662-9 pubmed
    ..synthase (TS), dihydropyrimidine dehydrogenase (DPD), and p53 as predictive values of clinical outcome in adenoid cystic carcinoma (ACC)...
  61. Mithani S, Shao C, Tan M, Smith I, Califano J, El Naggar A, et al. Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands. PLoS ONE. 2009;4:e8493 pubmed publisher
    ..The MitoChip v2.0 resequencing array is an array-based technique allowing for accurate and complete sequencing of the mitochondrial genome. No studies have investigated mitochondrial mutation in salivary gland adenoid cystic carcinomas...
  62. Pommier P, Liebsch N, Deschler D, Lin D, McIntyre J, Barker F, et al. Proton beam radiation therapy for skull base adenoid cystic carcinoma. Arch Otolaryngol Head Neck Surg. 2006;132:1242-9 pubmed
    To determine the treatment outcome and prognostic factors in patients with adenoid cystic carcinoma of the skull base treated with proton beam radiation therapy.
  63. Suemitsu R, Okamoto T, Maruyama R, Wataya H, Seto T, Ichinose Y. A long-term survivor after aggressive treatment for tracheal adenoid cystic carcinoma: a case report. Ann Thorac Cardiovasc Surg. 2007;13:335-7 pubmed
    ..male underwent a tracheal resection and reconstruction with omentopexy for the treatment of tracheal adenoid cystic carcinoma. Postoperatively, he received radiotherapy for a microscopic residual tumor of the tracheal margin...
  64. Seethala R, Pasha T, Raghunath P, LiVolsi V, Zhang P. The selective expression of CD43 in adenoid cystic carcinoma. Appl Immunohistochem Mol Morphol. 2008;16:165-72 pubmed publisher
    ..Hence, CD43 seems to be selectively expressed in a subset of ACC and its significance in salivary tumors is discussed...
  65. van Herpen C, Locati L, Buter J, Thomas J, Bogaerts J, Lacombe D, et al. Phase II study on gemcitabine in recurrent and/or metastatic adenoid cystic carcinoma of the head and neck (EORTC 24982). Eur J Cancer. 2008;44:2542-5 pubmed publisher
    This phase II study was conducted to determine the antitumour activity of gemcitabine in adenoid cystic carcinoma (ACC).
  66. Massoumi R, Paus R. Cylindromatosis and the CYLD gene: new lessons on the molecular principles of epithelial growth control. Bioessays. 2007;29:1203-14 pubmed
    ..We argue that these recent insights into CYLD function and cylindroma pathogenesis may lead to the development of novel molecular strategies for cancer prevention and treatment...
  67. Luna Ortiz K, Carmona Luna T, Cano Valdez A, Mosqueda Taylor A, Herrera Gomez A, Villavicencio Valencia V. Adenoid cystic carcinoma of the tongue--clinicopathological study and survival analysis. Head Neck Oncol. 2009;1:15 pubmed publisher
    To review the demographic data of a series of adenoid cystic carcinoma (ACC) of the tongue, as well as to analyze c-kit expression, histopathologic patterns, prognostic factors, evolution, recurrences and/or persistence and survival.
  68. Rabban J, Swain R, Zaloudek C, Chase D, Chen Y. Immunophenotypic overlap between adenoid cystic carcinoma and collagenous spherulosis of the breast: potential diagnostic pitfalls using myoepithelial markers. Mod Pathol. 2006;19:1351-7 pubmed
    b>Adenoid cystic carcinoma of the breast is a rare neoplasm whose cribriform architecture may mimic invasive cribriform carcinoma, cribriform ductal carcinoma in situ, and collagenous spherulosis...
  69. Da Silva L, Buck L, Simpson P, Reid L, McCallum N, Madigan B, et al. Molecular and morphological analysis of adenoid cystic carcinoma of the breast with synchronous tubular adenosis. Virchows Arch. 2009;454:107-14 pubmed publisher
    b>Adenoid cystic carcinoma (ACC) of the breast is a rare tumour...
  70. Laurie S, Licitra L. Systemic therapy in the palliative management of advanced salivary gland cancers. J Clin Oncol. 2006;24:2673-8 pubmed
    ..The majority of patients for whom systemic therapy is considered will have either adenoid cystic carcinoma, mucoepidermoid carcinoma, or high-grade adenocarcinoma...
  71. Hu K, Gan Y, Li S, Gao Y, Wu D, Wang C, et al. Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma. Oncol Rep. 2009;21:137-43 pubmed
    Lung metastasis is one of the important characteristics of salivary adenoid cystic carcinoma (SACC)...