acinar cell carcinoma

Summary

Summary: A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)

Top Publications

  1. Kamisawa T, Tu Y, Egawa N, Ishiwata J, Tsuruta K, Okamoto A, et al. Ductal and acinar differentiation in pancreatic endocrine tumors. Dig Dis Sci. 2002;47:2254-61 pubmed
    ..Only one K-ras gene mutation and no p53 gene alterations were detected in these tumors, which suggests that they constitute an entity with a different origin than ductal carcinomas...
  2. Wisnoski N, Townsend C, Nealon W, Freeman J, Riall T. 672 patients with acinar cell carcinoma of the pancreas: a population-based comparison to pancreatic adenocarcinoma. Surgery. 2008;144:141-8 pubmed publisher
    b>Acinar cell carcinoma (ACC) is a rare cancer of the pancreas accounting for approximately 1% of nonendocrine tumors...
  3. Seth A, Argani P, Campbell K, Cameron J, Pawlik T, Schulick R, et al. Acinar cell carcinoma of the pancreas: an institutional series of resected patients and review of the current literature. J Gastrointest Surg. 2008;12:1061-7 pubmed
    b>Acinar cell carcinoma (ACC) is a rare, malignant neoplasm with a generally poor prognosis. We report our institutional series of 14 patients with ACC to determine current guidelines for their evaluation and treatment.
  4. Schmidt C, Matos J, Bentrem D, Talamonti M, Lillemoe K, Bilimoria K. Acinar cell carcinoma of the pancreas in the United States: prognostic factors and comparison to ductal adenocarcinoma. J Gastrointest Surg. 2008;12:2078-86 pubmed publisher
    Pancreatic acinar cell carcinoma (ACC) is a rare tumor with poorly defined prognosis.
  5. Kolb van Harten P, Rosien U, Kloppel G, Layer P. Pancreatic acinar cell carcinoma with excessive alpha-fetoprotein expression. Pancreatology. 2007;7:370-2 pubmed
    We report a case of acinar cell carcinoma of the pancreas associated with excessively elevated levels of serum alpha-fetoprotein (>32,000 ng/ml)...
  6. Matos J, Schmidt C, Turrini O, Agaram N, Niedergethmann M, Saeger H, et al. Pancreatic acinar cell carcinoma: a multi-institutional study. J Gastrointest Surg. 2009;13:1495-502 pubmed publisher
    The presentation and outcome of patients with acinar cell carcinoma (ACC) of the pancreas compared to the more common ductal cell adenocarcinoma (DCA) may be distinct...
  7. Lee J, Kim T, Chang H, Lee S, Kim M, Kang Y, et al. Locally advanced acinar cell carcinoma of the pancreas successfully treated by capecitabine and concurrent radiotherapy: report of two cases. Pancreas. 2003;27:e18-22 pubmed
  8. Holen K, Klimstra D, Hummer A, Gonen M, Conlon K, Brennan M, et al. Clinical characteristics and outcomes from an institutional series of acinar cell carcinoma of the pancreas and related tumors. J Clin Oncol. 2002;20:4673-8 pubmed
    b>Acinar cell carcinoma is a rare tumor of the exocrine pancreas. Clinical features such as prognostic information, survival, and treatment outcomes are unknown. We present the largest retrospective review to date.
  9. Riechelmann R, Hoff P, Moron R, da Câmera Lopes L, Buzaid A. Acinar cell carcinoma of the pancreas. Int J Gastrointest Cancer. 2003;34:67-72 pubmed
    b>Acinar cell carcinoma of the pancreas is a rare tumor for which the best chemotherapy regimen has not been clearly established...

More Information

Publications80

  1. Minakawa K, Oka K, Nihei T, Sando N, Oikawa H, Toda J, et al. Pancreatic endocrine tumor with partial acinar cell differentiation. APMIS. 2006;114:720-5 pubmed
    ..Neuroendocrine and zymogen granules were simultaneously observed in the cytoplasm of the same neoplastic cells at the ultrastructural level. The tumor may be considered an amphicrine tumor...
  2. Seket B, Saurin J, Scoazec J, Partensky C. [Pancreatic acinar cell carcinoma in a patient with familial adenomatous polyposis]. Gastroenterol Clin Biol. 2003;27:818-20 pubmed
    ..After total pancreatectomy and antrectomy, histological examination revealed an acinar cell carcinoma and duodenal adenomas with low and high-grade dysplasia, but no cancer...
  3. Tapia B, Ahrens W, Kenney B, Touloukian R, Reyes Mugica M. Acinar cell carcinoma versus solid pseudopapillary tumor of the pancreas in children: a comparison of two rare and overlapping entities with review of the literature. Pediatr Dev Pathol. 2008;11:384-90 pubmed publisher
    Primary epithelial tumors of the pancreas are extremely uncommon in children, and among these, acinar cell carcinoma (ACC) is the most rare...
  4. Stelow E, Bardales R, Shami V, Woon C, Presley A, Mallery S, et al. Cytology of pancreatic acinar cell carcinoma. Diagn Cytopathol. 2006;34:367-72 pubmed
    b>Acinar cell carcinoma (ACC) of the pancreas is extremely uncommon and its cytologic features have rarely been described...
  5. Ambrosini Spaltro A, Potì O, De Palma M, Filotico M. Pancreatic-type acinar cell carcinoma of the stomach beneath a focus of pancreatic metaplasia of the gastric mucosa. Hum Pathol. 2009;40:746-9 pubmed publisher
    b>Acinar cell carcinoma is an uncommon type of carcinoma of the pancreas that can exceptionally arise in ectopic pancreatic tissue...
  6. Tobita K, Kijima H, Chino O, Dowaki S, Kashiwagi H, Tanaka M, et al. Pancreatic acinar cell carcinoma with endocrine differentiation: immunohistochemical and ultrastructural analyses. Anticancer Res. 2001;21:2131-4 pubmed
    ..We present here a rare case of acinar cell carcinoma with apparent foci of endocrine differentiation...
  7. Antoine M, Khitrik Palchuk M, Saif M. Long-term survival in a patient with acinar cell carcinoma of pancreas. A case report and review of literature. JOP. 2007;8:783-9 pubmed
    b>Acinar cell carcinoma of the pancreas is a rare malignancy that may have acinar and endocrine differentiation. Clinical practice guidelines exist for pancreatic ductal adenocarcinoma...
  8. Takanami K, Mitamura A, Miyazaki S, Abe K, Ishida K, Yamada S, et al. Two cases of 18 F-FDG PET/CT findings in acinar cell carcinoma of the pancreas. Clin Nucl Med. 2009;34:209-12 pubmed publisher
    ..They underwent F-18 FDG PET/CT and subsequently a pancreaticoduodenectomy and acinar cell carcinoma in the pancreas was proven histopathologically...
  9. Hashimoto M, Miki K, Beck Y, Kokudo N, Makuuchi M, Tanaka H. Femoral neck fracture as a complication of lipase-secreting pancreatic acinar cell carcinoma. Surgery. 2007;142:779-80 pubmed
  10. Distler M, Ruckert F, Dittert D, Stroszczynski C, Dobrowolski F, Kersting S, et al. Curative resection of a primarily unresectable acinar cell carcinoma of the pancreas after chemotherapy. World J Surg Oncol. 2009;7:22 pubmed publisher
    b>Acinar cell carcinoma (ACC) represents only 1-2% of pancreatic cancers and is a very rare malignancy. At the time of diagnosis only 50% of the tumors appear to be resectable...
  11. Seki Y, Okusaka T, Ikeda M, Morizane C, Ueno H. Four cases of pancreatic acinar cell carcinoma treated with gemcitabine or S-1 as a single agent. Jpn J Clin Oncol. 2009;39:751-5 pubmed publisher
    Pancreatic acinar cell carcinoma (ACC) is a comparatively rare tumor and account for approximately 1% of all cases of pancreatic cancer. Clinical presentation is usually related to either local spread or metastasis...
  12. Klimstra D. Nonductal neoplasms of the pancreas. Mod Pathol. 2007;20 Suppl 1:S94-112 pubmed
    ..The most common and best-characterized nonductal neoplasms are pancreatic endocrine neoplasm, acinar cell carcinoma, pancreatoblastoma, and solid pseudopapillary neoplasm...
  13. Lewis B, Klimstra D, Varmus H. The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer. Genes Dev. 2003;17:3127-38 pubmed
    ..Our model appears to be useful for elucidating the genetic alterations, target cells, and signaling pathways that are important in the genesis of different types of pancreatic cancer...
  14. Machado M, Machado M, Perini M, Herman P, Jukemura J, Leite K, et al. Acinar cell carcinoma of the pancreas: is the absence of neuroendocrine component related to a more malignant behavior?. Hepatogastroenterology. 2008;55:708-10 pubmed
    ..This discrepancy in prognosis may be related to the cellular components of the tumor...
  15. Ihrler S, Blasenbreu Vogt S, Sendelhofert A, Lang S, Zietz C, Löhrs U. Differential diagnosis of salivary acinic cell carcinoma and adenocarcinoma (NOS). A comparison of (immuno-)histochemical markers. Pathol Res Pract. 2002;198:777-83 pubmed
    ..In conclusion, we recommend CK 7 and 18 as the most valuable markers in cases with difficult differential diagnosis between ACC and AC-NOS...
  16. Abraham S, Wu T, Hruban R, Lee J, Yeo C, Conlon K, et al. Genetic and immunohistochemical analysis of pancreatic acinar cell carcinoma: frequent allelic loss on chromosome 11p and alterations in the APC/beta-catenin pathway. Am J Pathol. 2002;160:953-62 pubmed
    ..These results indicate that ACCs are genetically distinct from pancreatic ductal adenocarcinomas, but some cases contain genetic alterations common to histologically similar pancreatoblastomas...
  17. Fujii M, Sato H, Ogasawara T, Ando T, Tsujii S, Nagahori J, et al. [A case of liver metastasis of pancreatic acinar cell carcinoma treated with S-1 and intra-arterial CDDP combination therapy]. Gan To Kagaku Ryoho. 2010;37:1987-90 pubmed
    A 55-year-old man underwent a pylorus-preserving pancreatoduodenectomy in August 2006 because of acinar cell carcinoma of the head of the pancreas...
  18. Hashimoto M, Miki K, Kokudo N, Beck Y, Makuuchi M. A long-term survivor of metastatic acinar cell carcinoma. Pancreas. 2007;34:271-2 pubmed
  19. Mizuno Y, Sumi Y, Nachi S, Ito Y, Marui T, Saji S, et al. Acinar cell carcinoma arising from an ectopic pancreas. Surg Today. 2007;37:704-7 pubmed
    We herein report a rare case of ectopic pancreatic acinar cell carcinoma (ACC) which presented as a submucosal tumor of the pylorus. A 73-year-old man came to our hospital presenting with epigastralgia...
  20. Hervieu V, Lombard Bohas C, Dumortier J, Boillot O, Scoazec J. Primary acinar cell carcinoma of the liver. Virchows Arch. 2008;452:337-41 pubmed publisher
    We report a case of acinar cell carcinoma primary to the liver...
  21. Zhang N, Lyons S, Lim E, Lassota P. A spontaneous acinar cell carcinoma model for monitoring progression of pancreatic lesions and response to treatment through noninvasive bioluminescence imaging. Clin Cancer Res. 2009;15:4915-24 pubmed publisher
    ..We have generated an EL1-luc/TAg transgenic mouse model that develops spontaneous and bioluminescent acinar cell carcinomas. We applied this model to noninvasively monitor tumor development and drug response...
  22. Sorscher S. Metastatic acinar cell carcinoma of the pancreas responding to gemcitabine, 5-fluorouracil and leucovorin therapy: a case report. Eur J Cancer Care (Engl). 2009;18:318-9 pubmed
    b>Acinar cell carcinoma of the pancreas is rare tumour with a generally poor prognosis. There are very few reports of tumour regression following chemotherapy...
  23. Ordonez N. Pancreatic acinar cell carcinoma. Adv Anat Pathol. 2001;8:144-59 pubmed
    ..Although ACCs present a bland histology, they are highly malignant and the survival of patients with these tumors, even though better than that of those with ductal cell carcinomas, is generally poor...
  24. Tatli S, Mortele K, Levy A, Glickman J, Ros P, Banks P, et al. CT and MRI features of pure acinar cell carcinoma of the pancreas in adults. AJR Am J Roentgenol. 2005;184:511-9 pubmed
    We sought to describe the CT and MRI features of pure acinar cell carcinoma of the pancreas in adults.
  25. Ban D, Shimada K, Sekine S, Sakamoto Y, Kosuge T, Kanai Y, et al. Pancreatic ducts as an important route of tumor extension for acinar cell carcinoma of the pancreas. Am J Surg Pathol. 2010;34:1025-36 pubmed publisher
    b>Acinar cell carcinoma (ACC) of the pancreas is very rare, which usually grows expansively...
  26. Dewald G, Smyrk T, Thorland E, McWilliams R, Van Dyke D, Keefe J, et al. Fluorescence in situ hybridization to visualize genetic abnormalities in interphase cells of acinar cell carcinoma, ductal adenocarcinoma, and islet cell carcinoma of the pancreas. Mayo Clin Proc. 2009;84:801-10 pubmed publisher
    To use fluorescence in situ hybridization (FISH) to visualize genetic abnormalities in interphase cell nuclei (interphase FISH) of acinar cell carcinoma, ductal adenocarcinoma, and islet cell carcinoma of the pancreas.
  27. Martin S, Agarwal G, Lynch G. Subcutaneous fat necrosis as the presenting feature of a pancreatic carcinoma: the challenge of differentiating endocrine and acinar pancreatic neoplasms. Pancreas. 2009;38:219-22 pubmed publisher
    ..Accurate diagnosis of these tumors is necessary to determine prognosis and define appropriate therapy...
  28. Imamura M, Kimura Y, Ito H, Nobuoka T, Koito K, Sasaki A, et al. Acinar cell carcinoma of the pancreas with intraductal growth: report of a case. Surg Today. 2009;39:1006-9 pubmed publisher
    ..The tumor tends to present nonspecific symptoms. It occurs in older patients, and jaundice is infrequent. This report presents a case of ACC of the pancreas with intraductal papillary growth and lymph node metastasis...
  29. Suzuki A, Sakaguchi T, Morita Y, Oishi K, Fukumoto K, Inaba K, et al. Long-term survival after a repetitive surgical approach in a patient with acinar cell carcinoma of the pancreas and recurrent liver metastases: report of a case. Surg Today. 2010;40:679-83 pubmed publisher
    b>Acinar cell carcinoma is a relatively rare malignant neoplasm, which represents 1%-2% of all pancreatic exocrine tumors. Its prognosis is thought to be poor, especially when it metastasizes to the liver...
  30. Illyes G, Luczay A, Benyó G, Kálmán A, Borka K, Koves K, et al. Cushing's syndrome in a child with pancreatic acinar cell carcinoma. Endocr Pathol. 2007;18:95-102 pubmed
    ..Two years later, the patient died with metastatic disease. The presented case of ACC is interesting due to high serum AFP values and ectopic ACTH secretion resulting in Cushing's syndrome...
  31. Chiou Y, Chiang J, Hwang J, Yen C, Tsay S, Chang C. Acinar cell carcinoma of the pancreas: clinical and computed tomography manifestations. J Comput Assist Tomogr. 2004;28:180-6 pubmed
    b>Acinar cell carcinoma (ACC) is a subtype of pancreatic neoplasm sufficiently rare that its imaging has not been fully analyzed. The purpose of this article is to present the computed tomography (CT) appearance of ACC of the pancreas.
  32. Kitagami H, Kondo S, Hirano S, Kawakami H, Egawa S, Tanaka M. Acinar cell carcinoma of the pancreas: clinical analysis of 115 patients from Pancreatic Cancer Registry of Japan Pancreas Society. Pancreas. 2007;35:42-6 pubmed
    b>Acinar cell carcinoma (ACC) of the pancreas is a rare tumor, and many aspects remain unclear because no large-scale clinical studies have been conducted.
  33. Ohike N, Kosmahl M, Kloppel G. Mixed acinar-endocrine carcinoma of the pancreas. A clinicopathological study and comparison with acinar-cell carcinoma. Virchows Arch. 2004;445:231-5 pubmed
    ..The frequent identification of endocrine cells in these tumors suggests the existence of a pluripotent cell of origin that is capable of differentiating into acinar and endocrine cells...
  34. Jayaram G, Othman M, Kumar M, Krishnan G. Papillary cystic type of acinic cell carcinoma of parotid: fine needle aspiration cytological features of a high grade variant with oncocytic metaplasia. Malays J Pathol. 2002;24:107-12 pubmed
    ..ACC-PCV is an uncommon tumour and knowledge of its varied FNA cytological features is important for the diagnosis of this neoplasm. ..
  35. Negahban S, Daneshbod Y, Khademi B, Seif I. Papillary cystic acinic cell carcinoma with many psammoma bodies, so-called psammoma body-rich papillary cystic acinic cell carcinoma: report of a case with fine needle aspiration findings. Acta Cytol. 2009;53:440-4 pubmed
  36. Sato T, Kamata S, Kawabata K, Nigauri T, Mitani H, Beppu T, et al. Acinic cell carcinoma of the parotid gland in a child. Pediatr Surg Int. 2005;21:377-80 pubmed
    ..In our view, when tumors are completely encapsulated and do not adhere to the facial nerves, superficial parotidectomy is the best surgical treatment in children. ..
  37. Sharma S, Agarwal S, Nagendla M, Gupta D. Omental acinar cell carcinoma of pancreatic origin in a child: a clinicopathological rarity. Pediatr Surg Int. 2016;32:307-11 pubmed publisher
    ..Histopathology suggested acinar cell carcinoma of pancreatic origin in an ectopic location. The child is well at 5 months follow-up.
  38. Hammami B, Dhouib H, Sallemi M, Ben Hmida A, Ben Mahfoudh K, Daoud J, et al. [Acinic cell carcinoma of the nasal septum]. Rev Stomatol Chir Maxillofac. 2010;111:88-90 pubmed publisher
    ..Its septal origin is exceptional. It is usually located at the salivary gland level. Curative treatment is surgery associated or not to radiotherapy. The prognosis is related to tumor extension and quality of resection. ..
  39. Hamada T, Nanashima A, Hiyoshi M, Ikenoue M, Imamura N, Yano K, et al. Curative distal pancreatectomy in patients with acinar cell carcinoma of pancreas diagnosed by endoscopic aspiration via esophago-jejunostomy: A successful case report. Int J Surg Case Rep. 2018;42:274-279 pubmed publisher
    ..The cytological diagnosis with immunohistochemistry was acinar cell carcinoma of the pancreas. Distal pancreatectomy with splenectomy was successfully performed...
  40. Prieto Rodríguez M, Artes Martinez M, Navarro Hervás M, Camañas Sanz A, Vera Sempere F. Cytological characteristics of acinic cell carcinoma (ACC) diagnosed by fine-needle aspiration biopsy (FNAB). A study of four cases. Med Oral Patol Oral Cir Bucal. 2005;10:103-8 pubmed
    ..Our observations confirm the validity of FNAB in a first diagnostic approximation for those lesions accessible to direct puncture. ..
  41. Cao D, Maitra A, Saavedra J, Klimstra D, Adsay N, Hruban R. Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathways. Mod Pathol. 2005;18:752-61 pubmed
  42. Moore P, Orlandini S, Zamboni G, Capelli P, Rigaud G, Falconi M, et al. Pancreatic tumours: molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis. Br J Cancer. 2001;84:253-62 pubmed
    ..These data suggest that pancreatic exocrine and endocrine tumourigenesis involves different genetic targets and that among exocrine pancreatic neoplasms, only ductal and ampullary cancers share common molecular events. ..
  43. Hayama S, Ohmi M, Yonemori A, Yamabuki T, Inomata H, Nihei K, et al. Metachronous pancreatic acinar cell carcinoma discovered in early stage during follow-up of breast cancer: report of a case. Clin J Gastroenterol. 2012;5:257-60 pubmed publisher
    We present an extremely rare case of early-stage acinar cell carcinoma of the pancreas. A 49-year-old woman, who had undergone radical surgery for breast cancer 3 years earlier, was suspected to have a rib metastasis during follow-up...
  44. Ohike N, Morohoshi T. Exocrine Pancreatic Neoplasms of Nonductal Origin: Acinar Cell Carcinoma, Pancreatoblastoma, and Solid-Pseudopapillary Neoplasm. Surg Pathol Clin. 2011;4:579-88 pubmed publisher
    ..diagnosis, and biologic behavior of exocrine pancreatic tumors of predominantly nonductal differentiation: acinar cell carcinoma, pancreatoblastoma, and solid-pseudopapillary neoplasm...
  45. Psalla D, Geigy C, Konar M, Café Marçal V, Oevermann A. Nasal acinic cell carcinoma in a cat. Vet Pathol. 2008;45:365-8 pubmed publisher
    ..Clinicians and pathologists should be aware of the occurrence of acinic cell carcinoma in the sinonasal tract and include the tumor in the differential diagnosis of feline nasal diseases. ..
  46. Kuroda N, Hamaguchi N, Takeuchi E, Ohara M, Hirouchi T, Mizuno K. Lung adenocarcinoma with a micropapillary pattern: a clinicopathological study of 25 cases. APMIS. 2006;114:381-5 pubmed
    ..Lung micropapillary carcinoma of breast type may behave more aggressively than the alveolar type. ..
  47. Rubin M, de la Taille A, Bagiella E, Olsson C, O Toole K. Cribriform carcinoma of the prostate and cribriform prostatic intraepithelial neoplasia: incidence and clinical implications. Am J Surg Pathol. 1998;22:840-8 pubmed
    ..The close association between high tumor volume and HGCP supports the theory that the development of HGCP is a late event in tumor progression, more compatible with the intraductal spread of tumor than dysplasia. ..
  48. La Rosa S, Franzi F, Marchet S, Finzi G, Clerici M, Vigetti D, et al. The monoclonal anti-BCL10 antibody (clone 331.1) is a sensitive and specific marker of pancreatic acinar cell carcinoma and pancreatic metaplasia. Virchows Arch. 2009;454:133-42 pubmed publisher
    b>Acinar cell carcinoma (ACC) is a rare pancreatic cancer which may be difficult to distinguish from other solid nonadenocarcinoma tumors...
  49. Yu S, Hao Y, Lowe A. Effects of GP2 expression on secretion and endocytosis in pancreatic AR4-2J cells. Biochem Biophys Res Commun. 2004;322:320-5 pubmed
    ..Thus, GP2 expression in AR4-2J cells does not affect amylase packaging in secretory granules or stimulated secretion. GP2 expression also does not influence membrane recycling in response to stimulated stimulation in AR4-2J cells. ..
  50. Zhu L, Sidhu G, Cassai N, Yang G. Fine-needle aspiration cytology of pancreatoblastoma in a young woman: report of a case and review of the literature. Diagn Cytopathol. 2005;33:258-62 pubmed
    ..The literature was reviewed and the cytological features of all the four cases of pancreatoblastoma are summarized. ..
  51. Lee J, Lee K, Park H, Lee K. [Acinar cell carcinoma of the pancreas in Korea--clinicopathologic analysis of 27 patients from korean literature and 2 cases from our hospital--]. Korean J Gastroenterol. 2010;55:245-51 pubmed
    b>Acinar cell carcinoma (ACC) of the pancreas is a rare malignancy. ACC has been considered a cancer with poor prognosis due to frequent metastasis, a high recurrence rate, and low resectability...
  52. Ordonez N, Mackay B. Acinar cell carcinoma of the pancreas. Ultrastruct Pathol. 2000;24:227-41 pubmed
    Four cases of acinar cell carcinoma of the pancreas are reported. An acinar cell carcinoma can resemble an islet cell tumor by routine light microscopy but the two differ considerably in their fine structure and immunostaining properties...
  53. Neto A, Pineda Daboin K, Spencer M, Luna M. Sinonasal acinic cell carcinoma: a clinicopathologic study of four cases. Head Neck. 2005;27:603-7 pubmed
    ..To date, only 11 cases of sinonasal acinic cell carcinomas have been reported in the English-language literature. We present the clinicopathologic features of four sinonasal acinic cell carcinomas...
  54. Gallagher R, Hay T, Meniel V, Naughton C, Anderson T, Shibata H, et al. Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency. Oncogene. 2002;21:6446-57 pubmed
    ..However, additional deficiency of Tcf-1 completely blocks normal mammary development and results in acanthoma...
  55. Saleh T, Hakin K, Davidson M. Metastasis of acinic cell carcinoma of the parotid gland to the contralateral orbit. Arch Ophthalmol. 2003;121:1783-6 pubmed
  56. Matsuyama T, Ogata S, Sugiura Y, Yoshizumi Y, Aiko S, Aida S, et al. Acinar cell carcinoma of the pancreas eroding the pylorus and duodenal bulb. J Hepatobiliary Pancreat Surg. 2004;11:276-9 pubmed
    ..The histologic diagnosis was acinar cell carcinoma (ACC), originating in the pancreatic head and extending to the stomach, duodenum, and transverse colon, ..
  57. Mazzullo G, Sfacteria A, Ianelli N, De Majo M, Pennisi M. Carcinoma of the submandibular salivary glands with multiple metastases in a cat. Vet Clin Pathol. 2005;34:61-4 pubmed
    ..Bilateral salivary adenocarcinoma has not previously been reported in cats, and extensive metastases are rare...
  58. Schaeffer B, Terhune P, Longnecker D. Pancreatic carcinomas of acinar and mixed acinar/ductal phenotypes in Ela-1-myc transgenic mice do not contain c-K-ras mutations. Am J Pathol. 1994;145:696-701 pubmed
  59. Johnykutty S, Miller C, Hoda R, Giampoli E. Fine-needle aspiration of dedifferentiated acinic cell carcinoma: Report of a case with cyto-histological correlation. Diagn Cytopathol. 2009;37:763-8 pubmed publisher
    ..So far, to our knowledge, only one case of DAcCC has been reported in the cytology literature. Herein, we describe a second case of DAcCC from a fine-needle aspiration (FNA) along with its subsequent histological correlation...
  60. Goldman N, Lee J, Tolley B. Acinic cell carcinoma of the parotid gland. Otolaryngol Head Neck Surg. 2007;137:828-9 pubmed
  61. Delides A, Velegrakis G, Kontogeorgos G, Karagianni E, Nakas D, Helidonis E. Familial bilateral acinic cell carcinoma of the parotid synchronous with pituitary adenoma: case report. Head Neck. 2005;27:825-8 pubmed
    ..Acinic cell carcinoma is a common neoplasm of the salivary glands that occurs predominately in the parotid. Only one case of a familial recurrence of such a neoplasm and 16 cases of bilateral tumors have been reported...
  62. Cavalcanti F, Alves V, Pereira J, Kanamura C, Wakamatsu A, Saldanha L. Proliferative lesions of prostate: a multivariate approach to differential diagnosis. Pathol Oncol Res. 2005;11:103-7 pubmed
    ..Multivariate analysis selected a small panel of histological features as those most helpful in the differential diagnosis of proliferative lesions in prostate biopsies...
  63. Azua Romeo J, Sánchez Garnica J, Azúa Blanco J, Tovar Lázaro M. DNA quantification as prognostic factor in a case of acinar cell carcinoma of the parotid gland, diagnosed by FNA. Med Oral Patol Oral Cir Bucal. 2005;10:289-93 pubmed
    ..Fine needle aspiration cytology was performed, diagnosing of compatible with acinar cell carcinoma, thus DNA quantification by image cytometry was carried out...
  64. Piechocki M, Yoo G, Dibbley S, Amjad E, Lonardo F. Iressa induces cytostasis and augments Fas-mediated apoptosis in acinic cell adenocarcinoma overexpressing HER2/neu. Int J Cancer. 2006;119:441-54 pubmed
    ..These data showing that Iressa induces cytostasis and primes the extrinsic (Fas) and intrinsic (mitochondrial and endoplasmic reticulum) apoptotic pathways should lead to the development of novel therapeutic targets and strategies...
  65. Kataoka Y, Nio Y, Yano S, Koike M, Hashimoto K, Itakura M, et al. [Pancreatic acinar cell carcinoma successfully treated with combination of oral TS-1 and intra-arterial cisplatin]. Gan To Kagaku Ryoho. 2006;33:525-8 pubmed
    ..We report a 49-year old male patient with pancreatic acinar cell carcinoma and multiple liver metastases, which responded to oral TS-1 and hepatic arterial infusion of cisplatin...
  66. Imaoka H, Amano Y, Moriyama I, Itoh S, Yanagisawa A, Kinoshita Y. Endoscopic ultrasound-guided fine-needle aspiration of a mixed acinar-endocrine carcinoma: a case report. Am J Gastroenterol. 2008;103:2659-60 pubmed publisher
  67. Chidzonga M, Makunike Mutasa R. Acinic cell carcinoma of the submandibular salivary gland presenting as a large cyst. Int J Oral Maxillofac Surg. 2007;36:1215-7 pubmed
    ..The case of a long-standing, predominantly cystic, acinic cell carcinoma located in the submandibular gland of a child is presented here. The tumour was successfully removed and there has been no recurrence...
  68. Skalova A, Sima R, Vanecek T, Muller S, Korabecna M, Nemcova J, et al. Acinic cell carcinoma with high-grade transformation: a report of 9 cases with immunohistochemical study and analysis of TP53 and HER-2/neu genes. Am J Surg Pathol. 2009;33:1137-45 pubmed publisher
    ..Six of 9 patients (66%) died from tumor dissemination, all with a median overall survival of 4.3 years (range: 1 to 9 y). The high propensity for LN metastases indicates the need for neck dissection at the time of diagnosis...
  69. Nagler R, Ben Izhak O, Ostrovsky D, Golz A, Hershko D. The expression and prognostic significance of Cks1 in salivary cancer. Cancer Invest. 2009;27:512-20 pubmed publisher
    ..High expression of Cks1 WAS strongly associated with lymph node metastases and poor prognosis and survival. Cks1 alterations may have a significant biological role in the pathogenesis of salivary cancer...
  70. Luukkaa H, Laitakari J, Vahlberg T, Klemi P, Grenman R. Morphometric analysis using automated image analysis of CD34-positive vessels in salivary gland acinic cell carcinoma. Acta Otolaryngol. 2007;127:869-73 pubmed
    ..Bigger vessel size, vessel irregularity, and lower intensity of CD34-positive vessel staining may indicate unfavorable prognosis...
  71. Lopez J. Prostate adenocarcinoma detected after high-grade prostatic intraepithelial neoplasia or atypical small acinar proliferation. BJU Int. 2007;100:1272-6 pubmed