insulinoma

Summary

Summary: A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.

Top Publications

  1. Pigeau G, Kolic J, Ball B, Hoppa M, Wang Y, Ruckle T, et al. Insulin granule recruitment and exocytosis is dependent on p110gamma in insulinoma and human beta-cells. Diabetes. 2009;58:2084-92 pubmed publisher
    ..Thus, p110gamma activity plays an important role in maintaining a membrane-docked, readily releasable pool of secretory granules in insulinoma and human beta-cells.
  2. Djokovic D, Trindade A, Gigante J, Badenes M, Silva L, Liu R, et al. Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis. BMC Cancer. 2010;10:641 pubmed publisher
    ..Combination targeting of Dll4/Notch and Ephrin-B2/EphB4 has potential for clinical investigation, providing cumulative efficacy and increased safety over Dll4/Notch inhibition alone. ..
  3. Mei M, Deng D, Liu T, Sang X, Lu X, Xiang H, et al. Clinical implications of microsatellite instability and MLH1 gene inactivation in sporadic insulinomas. J Clin Endocrinol Metab. 2009;94:3448-57 pubmed publisher
    ..There is a lack of biomarker to distinguish benign and malignant form of insulinoma. Our objective was to confirm the occurrence of microsatellite instability (MSI) in insulinomas, to identify ..
  4. Zumsteg A, Caviezel C, Pisarsky L, Strittmatter K, Garcia Echeverria C, Hofmann F, et al. Repression of malignant tumor progression upon pharmacologic IGF1R blockade in a mouse model of insulinoma. Mol Cancer Res. 2012;10:800-9 pubmed publisher
    ..The results indicate that inhibition of IGF1R alone is not sufficient to efficiently block insulinoma growth and imply an overlapping role of IGF1R and insulin receptor in executing mitogenic and survival stimuli ..
  5. Nishi Y, Fujimoto S, Sasaki M, Mukai E, Sato H, Sato Y, et al. Role of mitochondrial phosphate carrier in metabolism-secretion coupling in rat insulinoma cell line INS-1. Biochem J. 2011;435:421-30 pubmed publisher
    ..001 to 10 mM, but did not affect ??m at 3 mM Pi. In conclusion, the Pi supply to mitochondria via PiC plays a critical role in ATP production and metabolism-secretion coupling in INS-1 cells...
  6. Langelueddecke C, Jakab M, Ketterl N, Lehner L, Hufnagl C, Schmidt S, et al. Effect of the AMP-kinase modulators AICAR, metformin and compound C on insulin secretion of INS-1E rat insulinoma cells under standard cell culture conditions. Cell Physiol Biochem. 2012;29:75-86 pubmed publisher
  7. Zhao Y, Zhan H, Zhang T, Cong L, Dai M, Liao Q, et al. Surgical management of patients with insulinomas: Result of 292 cases in a single institution. J Surg Oncol. 2011;103:169-74 pubmed publisher
    b>Insulinoma is rare tumor with an incidence of approximately four cases per million per year. There are few large sample, single-center series that focus on the surgical management strategy of insulinomas.
  8. Zhan H, Cong L, Zhao Y, Zhang T, Chen G, Zhou L, et al. Activated mTOR/P70S6K signaling pathway is involved in insulinoma tumorigenesis. J Surg Oncol. 2012;106:972-80 pubmed publisher
    b>Insulinoma was a rare tumor and its pathogenesis was poorly understood. There had no study that focused on the role of mTOR signaling pathway in insulinoma tumorigenesis.
  9. Liu S, Rao D, Nemunaitis J, Senzer N, Zhou G, Dawson D, et al. PDX-1 is a therapeutic target for pancreatic cancer, insulinoma and islet neoplasia using a novel RNA interference platform. PLoS ONE. 2012;7:e40452 pubmed publisher
    ..PDX-1 is a therapeutic target for both hormonal symptoms and tumor volume in mouse models of pancreatic cancer, insulinoma and islet neoplasia...

More Information

Publications66

  1. Preston A, Gurisik E, Bartley C, Laybutt D, Biden T. Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload. Diabetologia. 2009;52:2369-2373 pubmed publisher
    ..Our aim was to establish whether saturated fatty acids cause defects in ER-to-Golgi protein trafficking, which may thereby contribute to ER stress via protein overload...
  2. Sturla L, Fresia C, Guida L, Bruzzone S, Scarfi S, Usai C, et al. LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells. J Biol Chem. 2009;284:28045-57 pubmed publisher
    ..Recently, ABA was shown to be produced and released by human granulocytes, by insulin-producing rat insulinoma cells, and by human and murine pancreatic beta cells...
  3. Mathur A, Gorden P, Libutti S. Insulinoma. Surg Clin North Am. 2009;89:1105-21 pubmed publisher
    b>Insulinoma is a rare neuroendocrine tumor with an incidence of 4 per 1 million persons per year, which may occur as a unifocal sporadic event in patients without an inherited syndrome or as a part of multiple endocrine neoplasia type 1...
  4. Christ E, Wild D, Forrer F, Brandle M, Sahli R, Clerici T, et al. Glucagon-like peptide-1 receptor imaging for localization of insulinomas. J Clin Endocrinol Metab. 2009;94:4398-405 pubmed publisher
    ..Recently these tumors were shown to exhibit a very high density of glucagon-like peptide-1 receptors (GLP-1R) in vitro that may be used as specific targets for in vivo receptor radiolabeling...
  5. Sheline C, Shi C, Takata T, Zhu J, Zhang W, Sheline P, et al. Dietary zinc reduction, pyruvate supplementation, or zinc transporter 5 knockout attenuates ?-cell death in nonobese diabetic mice, islets, and insulinoma cells. J Nutr. 2012;142:2119-27 pubmed publisher
    ..Zn(2+)- and NAD(+)-mediated mechanisms are involved in ?-cell toxicity in models of ongoing T1DM using mouse insulinoma cells, islets, and nonobese diabetic (NOD) mice...
  6. Kauhanen S, Seppanen M, Minn H, Nuutila P. Clinical PET imaging of insulinoma and beta-cell hyperplasia. Curr Pharm Des. 2010;16:1550-60 pubmed
    Persistent hyperinsulinemic hypoglycemia (PHH) is caused by solitary benign insulinoma or hyperplasia of pancreatic beta cells...
  7. Ge Q, Du S, Bian F, Lin N, Su Q. Effects of lipopolysaccharides on TLR4 expression in INS-1 rat insulinoma cells. Cell Mol Biol (Noisy-le-grand). 2011;57 Suppl:OL1513-9 pubmed
    ..LPS increased TLR4 expression in the early short period of time and caused injury to INS-1 cells after a certain time. It could be one of the mechanisms that hyperglycemia occurs in the early stage of sepsis...
  8. Kwak T, Kim H, Jung O, Lee S, Kang M, Kim H, et al. Glucosamine treatment-mediated O-GlcNAc modification of paxillin depends on adhesion state of rat insulinoma INS-1 cells. J Biol Chem. 2010;285:36021-31 pubmed publisher
    ..We investigated the effects of O-GlcNAc modification on actin reorganization and morphology of rat insulinoma INS-1 cells after glucosamine (GlcN) treatment...
  9. Eriksson O, Velikyan I, Selvaraju R, Kandeel F, Johansson L, Antoni G, et al. Detection of metastatic insulinoma by positron emission tomography with [(68)ga]exendin-4-a case report. J Clin Endocrinol Metab. 2014;99:1519-24 pubmed publisher
    ..The glucagon like peptide-1 receptor (GLP-1R) is markedly up-regulated in insulinomas-especially benign lesions, which are difficult to localize with current imaging techniques...
  10. Wild D, Christ E, Caplin M, Kurzawinski T, Forrer F, Brandle M, et al. Glucagon-like peptide-1 versus somatostatin receptor targeting reveals 2 distinct forms of malignant insulinomas. J Nucl Med. 2011;52:1073-8 pubmed publisher
    ..Here, the role of GLP-1 and sst(2) receptor imaging in the management of malignant insulinoma patients was investigated.
  11. Muhlbauer E, Albrecht E, Bazwinsky Wutschke I, Peschke E. Melatonin influences insulin secretion primarily via MT(1) receptors in rat insulinoma cells (INS-1) and mouse pancreatic islets. J Pineal Res. 2012;52:446-59 pubmed publisher
    ..The data indicate that melatonin inhibits insulin secretion, primarily via the MT(1) receptor in rat INS-1 cells and isolated mouse islets...
  12. Epstein S, Kirkpatrick C, Castillon G, Muñiz M, Riezman I, David F, et al. Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells. J Lipid Res. 2012;53:412-20 pubmed publisher
    ..Therefore, our study reveals a novel connection between UPR induction and ceramide synthesis that seems to be conserved between yeast and mammalian cells...
  13. Han S, Choi S, Yi S, Lee S, Kim H, Kim D, et al. ?-Cell-protective effect of 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid as a glutamate dehydrogenase activator in db/db mice. J Endocrinol. 2012;212:307-15 pubmed publisher
    ..05). In conclusion, the GDH activator BCH improved glycemic control in db/db mice. This anti-diabetic effect may be associated with improved insulin secretion, preserved islet architecture, and reduced ?-cell apoptosis...
  14. Moore F, Cunha D, Mulder H, Eizirik D. Use of RNA interference to investigate cytokine signal transduction in pancreatic beta cells. Methods Mol Biol. 2012;820:179-94 pubmed publisher
    ..This chapter details the methods and settings used to achieve efficient and nontoxic transfection of small interfering RNA in immortal and primary beta cells...
  15. Gao H, Niu G, Yang M, Quan Q, Ma Y, Murage E, et al. PET of insulinoma using ¹?F-FBEM-EM3106B, a new GLP-1 analogue. Mol Pharm. 2011;8:1775-82 pubmed publisher
    ..In this study, we labeled a novel GLP-1 analogue, EM3106B, with (18)F and performed PET imaging to visualize insulinoma tumors in an animal model...
  16. Davì M, Boninsegna L, Dalle Carbonare L, Toaiari M, Capelli P, Scarpa A, et al. Presentation and outcome of pancreaticoduodenal endocrine tumors in multiple endocrine neoplasia type 1 syndrome. Neuroendocrinology. 2011;94:58-65 pubmed publisher
    ..To assess presentation and outcome of pancreaticoduodenal endocrine tumors (PDETs) in a single center series of multiple endocrine neoplasia type 1 (MEN1) patients...
  17. Janem W, Sultan I, Ajlouni F, Deebajeh R, Haddad H, Sughayer M, et al. Malignant insulinoma in a child. Pediatr Blood Cancer. 2010;55:1423-6 pubmed publisher
    ..Herein, we present a case of metastatic malignant insulinoma in a 12-year-old child...
  18. Brom M, Oyen W, Joosten L, Gotthardt M, Boerman O. 68Ga-labelled exendin-3, a new agent for the detection of insulinomas with PET. Eur J Nucl Med Mol Imaging. 2010;37:1345-55 pubmed publisher
    ..Glucagon-like peptide 1 (GLP-1), the natural ligand of GLP-1R, is rapidly degraded in vivo. A more stable agonist of GLP-1R is exendin-3. We investigated imaging of insulinomas with DOTA-conjugated exendin-3 labelled with (68)Ga...
  19. Zhang B, Jiang B, Chen Y, Huang H, Xie Q, Kang M, et al. Detection of viability of transplanted beta cells labeled with a novel contrast agent - polyvinylpyrrolidone-coated superparamagnetic iron oxide nanoparticles by magnetic resonance imaging. Contrast Media Mol Imaging. 2012;7:35-44 pubmed publisher
    ..superparamagnetic iron oxide nanoparticles (PVP-SPIO) - to label ?-TC-6 cells (a mouse insulinoma cell line) or primary islets with commercial Feridex as a control...
  20. Manabe M, Morimatsu H, Egi M, Suzuki S, Kaku R, Matsumi M, et al. [Anesthetic management of pediatric patients with insulinoma using continuous glucose monitoring]. Masui. 2009;58:757-9 pubmed
    ..We report the anesthetic management of a 5-year-old patient with insulinoma. Soon after the induction of anesthesia, the continuous glucose monitoring was commenced...
  21. Wu H, Liang S, Liu S, Pan Y, Cheng D, Zhang Y. 18F-radiolabeled GLP-1 analog exendin-4 for PET/CT imaging of insulinoma in small animals. Nucl Med Commun. 2013;34:701-8 pubmed publisher
    b>Insulinoma is a neuroendocrine tumor derived from the ? cells of pancreatic islets. They are usually relatively inaccessible for surgical intervention...
  22. Cohen Kutner M, Khomsky L, Trus M, Aisner Y, Niv M, Benhar M, et al. Thioredoxin-mimetic peptides (TXM) reverse auranofin induced apoptosis and restore insulin secretion in insulinoma cells. Biochem Pharmacol. 2013;85:977-90 pubmed publisher
    ..The Trx mimetics peptides (TXM) protected insulinoma INS 832/13 cells from oxidative stress induced by selectively inhibiting TrxR with auranofin (AuF)...
  23. Anaye A, Mathieu A, Closset J, Bali M, Metens T, Matos C. Successful preoperative localization of a small pancreatic insulinoma by diffusion-weighted MRI. JOP. 2009;10:528-31 pubmed
    b>Insulinoma is the most common functioning endocrine tumor of the pancreas responsible for fasting hypoglycemia resulting from autonomous insulin hypersecretion...
  24. Brown L, Longacre M, Hasan N, Kendrick M, Stoker S, MacDonald M. Chronic reduction of the cytosolic or mitochondrial NAD(P)-malic enzyme does not affect insulin secretion in a rat insulinoma cell line. J Biol Chem. 2009;284:35359-67 pubmed publisher
    ..Me1 mRNA levels by 80-86% and ME1 enzyme activity by 78-86% with either of two shRNAs in the INS-1 832/13 insulinoma cell line...
  25. Bertolotti A, Borgogna M, Facoetti A, Marsich E, Nano R. The effects of alginate encapsulation on NIT-1 insulinoma cells: viability, growth and insulin secretion. In Vivo. 2009;23:929-35 pubmed
    ..In particular, alginate encapsulation affects the cellular growth profile and causes the lost of time dependence of insulin secretion profile...
  26. Shin J, Gorden P, Libutti S. Insulinoma: pathophysiology, localization and management. Future Oncol. 2010;6:229-37 pubmed publisher
    b>Insulinoma is a rare neuroendocrine tumor that causes oversecretion of insulin and, as a result, patients present with symptoms of hypoglycemia...
  27. Ong G, Henley D, Hurley D, Turner J, Claringbold P, Fegan P. Therapies for the medical management of persistent hypoglycaemia in two cases of inoperable malignant insulinoma. Eur J Endocrinol. 2010;162:1001-8 pubmed publisher
    Hypoglycaemia poses a significant management challenge in patients with unresectable functional malignant insulinoma. Novel agents such as mammalian target of rapamycin (mTOR) inhibitors and radiolabelled peptides may be effective where ..
  28. Vaidakis D, Karoubalis J, Pappa T, Piaditis G, Zografos G. Pancreatic insulinoma: current issues and trends. Hepatobiliary Pancreat Dis Int. 2010;9:234-41 pubmed
    ..This review aimed to summarize classical knowledge with current trends in the diagnosis and treatment of insulinomas...
  29. Bazwinsky Wutschke I, Wolgast S, Muhlbauer E, Peschke E. Distribution patterns of calcium-binding proteins in pancreatic tissue of non-diabetic as well as type 2 diabetic rats and in rat insulinoma beta-cells (INS-1). Histochem Cell Biol. 2010;134:115-27 pubmed publisher
    ..different calcium-binding proteins (CaBPs) in the pancreatic tissue of non-diabetic and diabetic rats and in rat insulinoma beta-cells (INS-1)...
  30. Fiebrich H, Siemerink E, Brouwers A, Links T, Remkes W, Hospers G, et al. Everolimus induces rapid plasma glucose normalization in insulinoma patients by effects on tumor as well as normal tissues. Oncologist. 2011;16:783-7 pubmed publisher
    Mammalian target of rapamycin inhibitor everolimus administered to four insulinoma patients rapidly controlled hypoglycemia (Kulke et al., N Engl J Med 2009;360:195-197)...
  31. Karslioglu E, Kleinberger J, Salim F, Cox A, Takane K, Scott D, et al. cMyc is a principal upstream driver of beta-cell proliferation in rat insulinoma cell lines and is an effective mediator of human beta-cell replication. Mol Endocrinol. 2011;25:1760-72 pubmed publisher
    ..The cMyc pathway provides potential approaches, targets, and tools for driving and sustaining human ?-cell replication...
  32. Atiq M, Bhutani M, Bektas M, Lee J, Gong Y, Tamm E, et al. EUS-FNA for pancreatic neuroendocrine tumors: a tertiary cancer center experience. Dig Dis Sci. 2012;57:791-800 pubmed publisher
    ..With this background, we decided to review our experience from a tertiary cancer center with regard to the presentation and clinical features of PNET and the diagnostic utility of EUS-FNA in this scenario...
  33. Serewko Auret M, Mould A, Loffler K, Duncan R, Kay G, Hayward N. Alterations in gene expression in MEN1-associated insulinoma development. Pancreas. 2010;39:1140-6 pubmed publisher
    To identify gene expression alterations associated with insulinoma formation and progression in 2 mouse models of multiple endocrine neoplasia type 1.
  34. Duvillard L, Florentin E, Pont F, Petit J, Baillot Rudoni S, Penfornis A, et al. Chronic hyperinsulinemia does not increase the production rate of high-density lipoprotein apolipoprotein AI: evidence from a kinetic study in patients with insulinoma. Arterioscler Thromb Vasc Biol. 2013;33:2460-5 pubmed publisher
    ..Thus, we hypothesized that chronic hyperinsulinemia could contribute to the increase in the production of high-density lipoprotein apoAI that is observed in metabolic syndrome...
  35. Zhang B, Yang B, Zhai C, Jiang B, Wu Y. The role of exendin-4-conjugated superparamagnetic iron oxide nanoparticles in beta-cell-targeted MRI. Biomaterials. 2013;34:5843-52 pubmed publisher
    ..Toxicity assessments demonstrated good biocompatibility in vivo. These results suggest that SPIO-exendin4 has potential as molecularly targeted imaging agents for in vivo imaging of insulinoma, and possibly for future beta cell imaging.
  36. Lu J, Herrera P, Carreira C, Bonnavion R, Seigne C, Calender A, et al. Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development. Gastroenterology. 2010;138:1954-65 pubmed publisher
    ..The purpose of the current study was to address this issue in relation to islet tumor histogenesis...
  37. Huising M, Pilbrow A, Matsumoto M, van der Meulen T, Park H, Vaughan J, et al. Glucocorticoids differentially regulate the expression of CRFR1 and CRFR2? in MIN6 insulinoma cells and rodent islets. Endocrinology. 2011;152:138-50 pubmed publisher
    ..Here we demonstrate that CRFR2? is expressed by MIN6 insulinoma cells and by primary mouse and human islets, with no detectable expression of CRFR2?...
  38. Winer J, Choi H, Gibbs Strauss S, Ashitate Y, Colson Y, Frangioni J. Intraoperative localization of insulinoma and normal pancreas using invisible near-infrared fluorescent light. Ann Surg Oncol. 2010;17:1094-100 pubmed publisher
    Neuroendocrine tumors of the pancreas, such as insulinoma, are difficult to localize, and complete resection is essential for cure...
  39. Lin Y, Sun X, Qiu L, Wei J, Huang Q, Fang C, et al. Exposure to bisphenol A induces dysfunction of insulin secretion and apoptosis through the damage of mitochondria in rat insulinoma (INS-1) cells. Cell Death Dis. 2013;4:e460 pubmed publisher
    ..Taken together, these findings provide strong evidence that BPA triggers INS-1 cells dysfunction and apoptosis may be meditated via the mitochondrial pathway...
  40. Bazwinsky Wutschke I, Wolgast S, Muhlbauer E, Albrecht E, Peschke E. Phosphorylation of cyclic AMP-response element-binding protein (CREB) is influenced by melatonin treatment in pancreatic rat insulinoma ?-cells (INS-1). J Pineal Res. 2012;53:344-57 pubmed publisher
    ..In pancreatic rat insulinoma ?-cells (INS-1), pCREB immunofluorescence intensities in cell nuclei using digitised confocal image analysis ..
  41. Bernard V, Lombard Bohas C, Taquet M, Caroli Bosc F, Ruszniewski P, Niccoli P, et al. Efficacy of everolimus in patients with metastatic insulinoma and refractory hypoglycemia. Eur J Endocrinol. 2013;168:665-74 pubmed publisher
    Refractory hypoglycemia in patients with metastatic insulinoma is an important cause of morbidity and mortality. Everolimus could be a new therapeutic option.
  42. Yang R, Xi N, Lai K, Patterson K, Chen H, Song B, et al. Cellular biophysical dynamics and ion channel activities detected by AFM-based nanorobotic manipulator in insulinoma ?-cells. Nanomedicine. 2013;9:636-45 pubmed publisher
  43. Coelho C, Druce M, Grossman A. Diagnosis of insulinoma in a patient with hypoglycemia without obvious hyperinsulinemia. Nat Rev Endocrinol. 2009;5:628-31 pubmed publisher
    ..She was not taking medication and did not report any prior personal or familial history of endocrinopathy or other relevant pathology...
  44. Cao Y, Gao Z, Li L, Jiang X, Shan A, Cai J, et al. Whole exome sequencing of insulinoma reveals recurrent T372R mutations in YY1. Nat Commun. 2013;4:2810 pubmed publisher
    Functional pancreatic neuroendocrine tumours (PNETs) are mainly represented by insulinoma, which secrete insulin independent of glucose and cause hypoglycaemia. The major genetic alterations in sporadic insulinomas are still unknown...
  45. Reubi J, Perren A, Rehmann R, Waser B, Christ E, Callery M, et al. Glucagon-like peptide-1 (GLP-1) receptors are not overexpressed in pancreatic islets from patients with severe hyperinsulinaemic hypoglycaemia following gastric bypass. Diabetologia. 2010;53:2641-5 pubmed publisher
    ..The present study sought to evaluate the GLP-1 receptor status in vitro in other pancreatic disorders leading to hyperinsulinaemic hypoglycaemia, specifically after gastric bypass surgery...
  46. Kiesewetter D, Gao H, Ma Y, Niu G, Quan Q, Guo N, et al. 18F-radiolabeled analogs of exendin-4 for PET imaging of GLP-1 in insulinoma. Eur J Nucl Med Mol Imaging. 2012;39:463-73 pubmed publisher
    ..The abundance of GLP-1R in pancreatic ?-cells in insulinoma, a cancer of the pancreas, and the activity of GLP-1 in the cardiovascular system have made GLP-1R a target for ..
  47. Sheng H, Hassanali S, Nugent C, Wen L, Hamilton Williams E, Dias P, et al. Insulinoma-released exosomes or microparticles are immunostimulatory and can activate autoreactive T cells spontaneously developed in nonobese diabetic mice. J Immunol. 2011;187:1591-600 pubmed publisher
    ..To test possible roles of EXO in autoimmunity, we isolated small microparticles, mainly EXO, from mouse insulinoma and examined their activities to stimulate the autoimmune responses in NOD mice, a model for human type 1 ..
  48. Burke S, Collier J. The gene encoding cyclooxygenase-2 is regulated by IL-1? and prostaglandins in 832/13 rat insulinoma cells. Cell Immunol. 2011;271:379-84 pubmed publisher
    ..In addition, PGD(2) and PGE(2) coordinately alter COX2 and EP receptor gene expression patterns and potentiate the cytokine-mediated transcriptional activity of promoters containing NF-?B or GAS response elements...
  49. Cárdenas C, Dominguez I, Campuzano M, Bezaury P, Iñiguez Rodríguez M, Gamboa Dominguez A, et al. Malignant insulinoma arising from intrasplenic heterotopic pancreas. JOP. 2009;10:321-3 pubmed
    ..The spleen is a rare site of origin. This case report describes a patient with a malignant insulinoma which originated from an intrasplenic heterotopic pancreas.
  50. An L, Li W, Yao K, Liu R, Lv F, Tang J, et al. Assessment of contrast-enhanced ultrasonography in diagnosis and preoperative localization of insulinoma. Eur J Radiol. 2011;80:675-80 pubmed publisher
    This study was to evaluate the value of contrast-enhanced ultrasonography (CEUS) in the diagnosis and preoperative localization of insulinoma and explore the enhancement patterns of the tumors.
  51. Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Ito S, Ogawa Y, et al. Diagnosis and management of insulinoma. World J Gastroenterol. 2013;19:829-37 pubmed publisher
    ..Common autonomic symptoms of insulinoma include diaphroresis, tremor, and palpitations, whereas neuroglycopenenic symptoms include confusion, ..
  52. Chen Z, Li Y, Han J, Yin J, Wang Y, Zhu L, et al. Liraglutide prevents high glucose level induced insulinoma cells apoptosis by targeting autophagy. Chin Med J (Engl). 2013;126:937-41 pubmed
    ..The aim of our study was to evaluate whether liraglutide can inhibit apoptosis and modulate autophagy in vitro in insulinoma cells (INS-1 cells).
  53. Jawiarczyk A, Bolanowski M, Syrycka J, Bednarek Tupikowska G, Kałuzny M, Kołodziejczyk A, et al. Effective therapy of insulinoma by using long-acting somatostatin analogue. A case report and literature review. Exp Clin Endocrinol Diabetes. 2012;120:68-72 pubmed publisher
    We are reporting a case of 68-year-old woman with insulinoma, after a non-successful tumor surgery and a long-term diazoxide treatment. She had a lot of hypoglycemia cases, and a weight gain of 50?kg...
  54. Brambillasca S, Altkrueger A, Colombo S, Friederich A, Eickelmann P, Mark M, et al. CDK5 regulatory subunit-associated protein 1-like 1 (CDKAL1) is a tail-anchored protein in the endoplasmic reticulum (ER) of insulinoma cells. J Biol Chem. 2012;287:41808-19 pubmed publisher
    ..only isoform 1, which migrates as a 61-kDa protein by SDS-PAGE, is expressed in human islets and pancreatic insulinoma INS-1 and MIN6 cells...
  55. Muhlbauer E, Albrecht E, Hofmann K, Bazwinsky Wutschke I, Peschke E. Melatonin inhibits insulin secretion in rat insulinoma ?-cells (INS-1) heterologously expressing the human melatonin receptor isoform MT2. J Pineal Res. 2011;51:361-72 pubmed publisher
    ..constitutively expressed human recombinant MT2 receptor (hMT2) and its impact on insulin secretion, using a rat insulinoma ?-cell line (INS-1)...
  56. Chandra P, Yarandi S, Khazai N, Jacobs S, Umpierrez G. Management of intractable hypoglycemia with Yttirum-90 radioembolization in a patient with malignant insulinoma. Am J Med Sci. 2010;340:414-7 pubmed publisher
    ..The authors present our experience with Yttirum-90 radioembolization in a patient with metastatic malignant insulinoma who failed to respond to distal pancreatectomy, systemic chemotherapy with capecitabine and everolimus and ..
  57. Kamijima T, Sakashita M, Miura A, Nishimiya Y, Tsuda S. Antifreeze protein prolongs the life-time of insulinoma cells during hypothermic preservation. PLoS ONE. 2013;8:e73643 pubmed publisher
    ..Here we found an ability of hypothermic (+4°C) preservation of fish antifreeze protein (AFP) against rat insulinoma cells denoted as RIN-5F...