serous cystadenoma


Summary: A cystic tumor of the ovary, containing thin, clear, yellow serous fluid and varying amounts of solid tissue, with a malignant potential several times greater than that of mucinous cystadenoma (CYSTADENOMA, MUCINOUS). It can be unilocular, parvilocular, or multilocular. It is often bilateral and papillary. The cysts may vary greatly in size. (Dorland, 27th ed; from Hughes, Obstetric-Gynecologic Terminology, 1972)

Top Publications

  1. Blandamura S, Parenti A, Famengo B, Canesso A, Moschino P, Pasquali C, et al. Three cases of pancreatic serous cystadenoma and endocrine tumour. J Clin Pathol. 2007;60:278-82 pubmed
    To report three cases of serous cystadenoma and endocrine tumour in the same pancreas, to review the literature and to evaluate the clinicopathological features of the tumours.
  2. Berman L, Mitchell K, Israel G, Salem R. Serous cystadenoma in communication with the pancreatic duct: an unusual radiologic and pathologic entity. J Clin Gastroenterol. 2010;44:e133-5 pubmed publisher
    ..of a patient with presumed intraductal papillary mucinous neoplasm (IPMN) who was ultimately found to have a serous cystadenoma in communication with the pancreatic duct...
  3. Abe H, Kimura W, Mori M, Makuuchi M, Yanagisawam A. Mixed serous cystadenoma with mucinous cystadenoma of the pancreas. Pancreas. 2005;31:98-100 pubmed
    We report a case of serous cystadenoma of the pancreas mixed with mucinous cystadenoma...
  4. Khalbuss W, Dipasquale B. Massive ovarian edema associated with ovarian serous cystadenoma: a case report and review of the literature. Int J Gynecol Cancer. 2006;16 Suppl 1:326-30 pubmed
    ..This article describes the first case of an ovarian serous cystadenoma associated with a massive ovarian edema...
  5. Shih I, Kurman R. Molecular pathogenesis of ovarian borderline tumors: new insights and old challenges. Clin Cancer Res. 2005;11:7273-9 pubmed
    ..This review summarizes recent molecular studies of ovarian borderline tumors with special emphasis on the role of SBT in tumor progression and its relationship to ovarian serous carcinoma...
  6. Seidman J, Ronnett B, Kurman R. Pathology of borderline (low malignant potential) ovarian tumours. Best Pract Res Clin Obstet Gynaecol. 2002;16:499-512 pubmed
    ..The remaining mucinous borderline tumours are always confined to the ovaries and have a benign behaviour. Since borderline tumours can now be classified into benign and malignant types, the category has no further utility...
  7. Colonna J, Plaza J, Frankel W, Yearsley M, Bloomston M, Marsh W. Serous cystadenoma of the pancreas: clinical and pathological features in 33 patients. Pancreatology. 2008;8:135-41 pubmed publisher
    ..To report the clinicopathological features of patients with serous cystadenomas of the pancreas...
  8. Belsley N, Pitman M, Lauwers G, Brugge W, Deshpande V. Serous cystadenoma of the pancreas: limitations and pitfalls of endoscopic ultrasound-guided fine-needle aspiration biopsy. Cancer. 2008;114:102-10 pubmed publisher
    Expectant management of serous cystadenoma (SCA) of the pancreas requires an accurate preoperative diagnosis. Previously published cytologic diagnostic sensitivities have ranged widely, from 10% to 100%...
  9. Tseng J, Warshaw A, Sahani D, Lauwers G, Rattner D, Fernandez del Castillo C. Serous cystadenoma of the pancreas: tumor growth rates and recommendations for treatment. Ann Surg. 2005;242:413-9; discussion 419-21 pubmed
    To define the natural history and optimal management of serous cystadenoma of the pancreas.

More Information


  1. Hung J, Yang C, Hu R, Lee P, Tien Y. Surgical treatment of pancreatic serous cystadenoma: aggressive for operations but limited resections. Pancreas. 2007;35:358-60 pubmed
    ..Serous cystadenomas of the pancreas are being increasingly identified as the advancement of the diagnostic abdominal imaging. However, the optimal timing of surgical intervention for this disease remains controversial...
  2. Allen P, Qin L, Tang L, Klimstra D, Brennan M, Lokshin A. Pancreatic cyst fluid protein expression profiling for discriminating between serous cystadenoma and intraductal papillary mucinous neoplasm. Ann Surg. 2009;250:754-60 pubmed publisher
    Many patients with benign serous cystadenoma (SCA) of the pancreas will undergo resection because of the inability to reliably discriminate between SCA and premalignant mucinous cysts (intraductal papillary mucinous neoplasm [IPMN], ..
  3. Ustün M, Tugyan N, Tunakan M. Coexistence of an endocrine tumour in a serous cystadenoma (microcystic adenoma) of the pancreas, an unusual association. J Clin Pathol. 2000;53:800-2 pubmed
    A pancreatic endocrine tumour arising within a serous cystadenoma is reported. A 49 year old woman was admitted with a history of epigastric pain, nausea, vomiting, and weight loss of two months duration...
  4. Tampi C, Mullerpatan P, Shah R, Jagannath P, Zimmermann A. Microcystic serous cystadenoma of the pancreas: a report of two cases with one of diffuse presentation. Pancreatology. 2006;6:248-53 pubmed
    Microcystic adenoma or serous cystadenoma is an uncommon tumor and accounts for 1-2% of the exocrine neoplasms of the pancreas...
  5. Horaguchi J, Fujita N, Kobayashi G, Noda Y, Kimura K, Ito K, et al. Serous cystadenoma of the pancreas associated with obstructive jaundice. J Gastroenterol. 2003;38:501-6 pubmed
    We herein report a case of pancreatic serous cystadenoma in a patient who presented with jaundice, and we provide a review of the literature. A 53-year-old man was admitted with complaints of jaundice and weight loss...
  6. Tseng J. Management of serous cystadenoma of the pancreas. J Gastrointest Surg. 2008;12:408-10 pubmed
    b>Serous cystadenoma of the pancreas is a diagnosis being entertained with increasing frequency...
  7. Bell D, Longacre T, Prat J, Kohn E, Soslow R, Ellenson L, et al. Serous borderline (low malignant potential, atypical proliferative) ovarian tumors: workshop perspectives. Hum Pathol. 2004;35:934-48 pubmed
  8. Bassi C, Salvia R, Molinari E, Biasutti C, Falconi M, Pederzoli P. Management of 100 consecutive cases of pancreatic serous cystadenoma: wait for symptoms and see at imaging or vice versa?. World J Surg. 2003;27:319-23 pubmed
    ..This is mainly relevant to the oligocystic forms, which account for about one fourth of all serous tumors observed...
  9. Dietel M, Hauptmann S. Serous tumors of low malignant potential of the ovary. 1. Diagnostic pathology. Virchows Arch. 2000;436:403-12 pubmed
    ..The concepts of molecular pathology of SLMP will be discussed in part 2 of this serial paper.)..
  10. Aluka K, Long C, Rickford M, Turner P, McKenna S, Fullum T. Laparoscopic distal pancreatectomy with splenic preservation for serous cystadenoma: a case report and literature review. Surg Innov. 2006;13:94-101 pubmed
    ..A computed tomography scan to rule out a functional adrenal mass incidentally revealed a 4 cm x 3 cm x 2 cm serous cystadenoma of the distal pancreas and normal adrenal glands...
  11. Singer G, Kurman R, Chang H, Cho S, Shih I. Diverse tumorigenic pathways in ovarian serous carcinoma. Am J Pathol. 2002;160:1223-8 pubmed
    ..The other pathway is characterized by rapid progression from the ovarian surface epithelium or inclusion cysts to a conventional (high-grade) serous carcinoma...
  12. Nitta H, Hirota M, Ohkado A, Motomura Y, Chikamoto A, Shibata M, et al. Coexistence of serous cystadenoma and ductal adenocarcinoma in the pancreas: a case report. Pancreas. 2008;36:218-9 pubmed publisher
  13. Kurman R, Seidman J, Shih I. Serous borderline tumours of the ovary. Histopathology. 2005;47:310-5 pubmed
    ..The significance of a micropapillary pattern is discussed, and issues related to extra-ovarian implants...
  14. Ito K, Kudo A, Nakamura N, Tanaka S, Teramoto K, Arii S. Left-sided portal hypertension caused by serous cystadenoma of the pancreas: report of a case. Surg Today. 2008;38:184-7 pubmed publisher
    We report a case of serous cystadenoma of pancreas causing left-sided portal hypertension and gastric varices. A 68-year-old man was admitted for treatment of a pancreatic body tumor...
  15. Pinarbasi B, Poturoglu S, Yanar H, Guven K, Akyuz F, Dizdaroglu F, et al. A rare cause of hemosuccus pancreaticus: primary splenic artery aneurysm ruptured into pancreatic serous cystadenoma. Turk J Gastroenterol. 2008;19:57-63 pubmed
    ..intraabdominal haemorrhagia had occurred with the rupture of a splenic artery aneurysm into a pancreatic serous cystadenoma, which ruptured into the abdomen because of high pressure...
  16. Choi J, Kim M, Lee J, Lim J, Chung J, Kim K, et al. Typical and atypical manifestations of serous cystadenoma of the pancreas: imaging findings with pathologic correlation. AJR Am J Roentgenol. 2009;193:136-42 pubmed publisher
    The purpose of this article is to present the typical and atypical manifestations of serous cystadenoma, which can be visualized with cross-sectional imaging.
  17. Watanabe H, Ohtsubo K, Yamaguchi Y, Mouri H, Motoo Y, Noto M, et al. Successful cystic fenestration for a macrocystic serous cystadenoma of the pancreas causing obstructive jaundice: report of a case. Surg Today. 2006;36:89-93 pubmed
    ..We made a preoperative diagnosis of macrocystic serous cystadenoma (SCA) of the pancreas, but did not perform palliative choledochojejunostomy because aspiration of the ..
  18. Yamaguchi M. Solid serous adenoma of the pancreas: a solid variant of serous cystadenoma or a separate disease entity?. J Gastroenterol. 2006;41:178-9 pubmed
  19. Okuyama M, Fujiwara Y, Hayakawa T, Shiba M, Watanabe T, Tominaga K, et al. Esophagogastric varices due to arterioportal shunt in a serous cystadenoma of the pancreas in von Hippel-Lindau disease. Dig Dis Sci. 2003;48:1948-54 pubmed
    ..we describe a rare case of VHL disease with esophageal and gastric varices due to arterioportal shunt in a serous cystadenoma of the pancreas, which, upon immunohistochemical examination, exhibited HIF-1alpha and VEGF expression...
  20. Sanaka M, Kowalski T, Brotz C, Yeo C, McCue P, Palazzo J. Solid serous adenoma of the pancreas: a rare form of serous cystadenoma. Dig Dis Sci. 2007;52:3154-6 pubmed
  21. Koksal A, Ulker A, Asil M, Tunc B, Arda K, Savkilioglu M, et al. Serous cystadenoma of the pancreas presenting as a third primary neoplasm. Can J Gastroenterol. 2003;17:552-4 pubmed
    ..This is the first report of a serous cystadenoma of the pancreas with two metachronous neoplasms...
  22. Gabata T, Terayama N, Yamashiro M, Takamatsu S, Yoshida K, Matsui O, et al. Solid serous cystadenoma of the pancreas: MR imaging with pathologic correlation. Abdom Imaging. 2005;30:605-9 pubmed
    We report a case of solid type serous cystadenoma of the pancreas. Computed tomographic and magnetic resonance (MR) images showed a hypervascular solid tumor that was difficult to differentiate from endocrine tumor of the pancreas...
  23. Agarwal N, Kumar S, Dass J, Arora V, Rathi V. Diffuse pancreatic serous cystadenoma associated with neuroendocrine carcinoma: a case report and review of literature. JOP. 2009;10:55-8 pubmed
    ..The management of these tumors poses a challenge due to their rarity and uncertain malignant potential. We report a case of diffuse serous cystadenoma associated with neuroendocrine carcinoma in a 35-year-old woman.
  24. Chen V, Ruiz B, Killeen J, Cote T, Wu X, Correa C. Pathology and classification of ovarian tumors. Cancer. 2003;97:2631-42 pubmed
  25. Stankovic Z, Djuricic S, Djukic M, Jovanovic D, Vasiljevic M. Epithelial ovarian tumors and CA125 in premenarchal girls. Eur J Gynaecol Oncol. 2006;27:597-9 pubmed
    ..CA125 is a tumor marker with low sensitivity and specificity for detection of epithelial ovarian malignancy in this age group. ..
  26. Itoi T, Sofuni A, Itokawa F, Moriyasu F. [Percutaneous transhepatic cholangiography for diagnosis of pancreatic tumors]. Nihon Rinsho. 2006;64 Suppl 1:129-34 pubmed
  27. Mazanowska N, Rajski D, Pietrzak B, Kaminski P, Wielgos M. Should We Be Concerned About Asymptomatic Adnexal Masses in Female Kidney and Liver Graft Recipients?. Transplant Proc. 2016;48:1532-4 pubmed publisher
    ..examination revealed that in both groups, the most often encountered pathological findings were serous cystadenoma (33.3% and 47% of patients, respectively), endometrial cysts (24.6% and 21...
  28. Maruyama H, Ohyama N, Hosokawa Y, Momose H, Yamada K, Tsutsumi M, et al. Serous borderline tumor of the paratestis. Pathol Int. 2008;58:311-6 pubmed publisher
    ..The lesion in the present case was concluded to be a testicular serous tumor of Müllerian type, similar to SBT of the ovary. ..
  29. Seidman J, Sherman M, Bell K, Katabuchi H, O Leary T, Kurman R. Salpingitis, salpingoliths, and serous tumors of the ovaries: is there a connection?. Int J Gynecol Pathol. 2002;21:101-7 pubmed
    ..In addition, the high frequency of salpingitis in women with endometriosis may be related to the mechanism of endometriosis-associated infertility...
  30. Stacher E, Pristauz G, Scholz H, Moinfar F. Bilateral ovarian well-differentiated Sertoli-Leydig cell tumors with heterologous elements associated with unilateral serous cystadenoma--a case report. Int J Gynecol Pathol. 2010;29:419-22 pubmed publisher
    ..Furthermore, on the left side it also was associated with a serous cystadenoma.
  31. Wertel F, Polak G, Rolinski J, Barczynski B, Kotarski J. Myeloid and lymphoid dendritic cells in the peritoneal fluid of women with ovarian cancer. Adv Med Sci. 2006;51:174-7 pubmed
    ..We studied 34 patients with serous cystadenocarcinoma and 29 women with serous cystadenoma. Dendritic cells were isolated from peritoneal fluid, stained with monoclonal antibodies anti-BDCA-1 and ..
  32. Chamberlin M, Eltabbakh G, Mount S, Leavitt B. Metastatic serous borderline ovarian tumor in an internal mammary lymph node: a case report and review of the literature. Gynecol Oncol. 2001;82:212-5 pubmed
    ..Borderline ovarian tumors should be included in the differential diagnosis of metastatic adenocarcinoma involving the supradiaphragmatic lymph nodes. ..
  33. Rollins S, Young R, Bell D. Autoimplants in serous borderline tumors of the ovary: a clinicopathologic study of 30 cases of a process to be distinguished from serous adenocarcinoma. Am J Surg Pathol. 2006;30:457-62 pubmed
  34. Bondiau P, Largillier R, Foa C, Rasendrarijao D, Frenay M, Gerard J. [Treatment of brain metastasis from ovarian cancer]. Cancer Radiother. 2003;7:184-6 pubmed
    ..Taking into account the increase in the incidence of the CMOC and their early occurrence, some authors have proposed a prophylactic brain radiotherapy in patients who receive adjuvant chemotherapy. ..
  35. Chen A, Zhang J, Liu H, Zhao S, Dai S, Sun X. [Association of EGFR expression with angiogenesis and chemoresistance in ovarian carcinoma]. Zhonghua Zhong Liu Za Zhi. 2009;31:48-52 pubmed
    ..LRP-positive expression and chemotherapeutic effect may be independent prognostic factors. ..
  36. Shao S, Cai Y, Wang Q, Yan L, Zhao X, Wang L. [Expression of GLUT-1, p63 and DNA-Pkcs in serous ovarian tumors and their significance]. Zhonghua Zhong Liu Za Zhi. 2007;29:697-700 pubmed
    ..05). The results suggest that the abnormal expression of GTUT1, p63 and DNA-Pkcs may perhaps participate in serous ovarian tumor occurrence and development and may be considered as a marker reflecting tumor malignant behavior. ..
  37. Alborzi S, Foroughinia L, Kumar P, Asadi N, Alborzi S. A comparison of histopathologic findings of ovarian tissue inadvertently excised with endometrioma and other kinds of benign ovarian cyst in patients undergoing laparoscopy versus laparotomy. Fertil Steril. 2009;92:2004-7 pubmed publisher
    ..The surgical approach had no statistically significant impact on conservation of ovarian reserves. The nature of the ovarian cyst played a greater role in the quality and quantity of the excised ovarian tissue. ..
  38. Ooi L, Ho G, Chew S, Low C, Soo K. Cystic tumours of the pancreas: a diagnostic dilemma. Aust N Z J Surg. 1998;68:844-6 pubmed
    ..5 months. The difficulties with pre-operative diagnosis, the high incidence of tumours with potential malignancy, and the good outcome with resection, suggest that all suspected cystic tumours of the pancreas should be resected. ..
  39. Echenique Elizondo M. Image of the month. Giant serous microcystic cystadenoma of the pancreas. Arch Surg. 2003;138:1157-8 pubmed
  40. Rangel L, Agarwal R, D Souza T, Pizer E, Alo P, Lancaster W, et al. Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas. Clin Cancer Res. 2003;9:2567-75 pubmed
    ..A better knowledge of the mechanisms underlying ovarian tumorigenesis will likely result in the development of novel approaches for the diagnosis and therapy of this deadly disease. ..
  41. Davidson B, Lazarovici P, Ezersky A, Nesland J, Berner A, Risberg B, et al. Expression levels of the nerve growth factor receptors TrkA and p75 in effusions and solid tumors of serous ovarian carcinoma patients. Clin Cancer Res. 2001;7:3457-64 pubmed
    ..TrkA and p75 expression in effusions does not appear to be a predictor of disease outcome in advanced-stage serous ovarian carcinoma. ..
  42. Fitzgerald T, Smith A, Ryan M, Atri M, Wright F, Law C, et al. Surgical treatment of incidentally identified pancreatic masses. Can J Surg. 2003;46:413-8 pubmed
    ..The histologic type of the masses included neuroendocrine tumour (3), serous cystadenoma (2), intraductal papillary mucinous tumour (1) and papillary cystic and solid tumour (1)...
  43. Dobrowolski F, Saeger H. [The therapy of benign pancreatic tumors]. Zentralbl Chir. 2003;128:424-8 pubmed
    ..5 years in our institution with the following operative procedures: 2 total pancreatectomies, 21 pancreatic head resections, 25 left pancreatectomies, 10 pancreas segmental resections amd 2 enucleations. ..
  44. Smart J, Blaquiere R. Synchronous serous cystadenomas of the pancreas. Clin Radiol. 2002;57:532-4 pubmed
  45. Eras M, Yenigun M, Acar C, Kumbasar B, Sar F, Bilge T. Pancreatic involvement in Von Hippel-Lindau disease. Indian J Cancer. 2004;41:159-61 pubmed
    ..Shortly, even pancreatic involvement in VHL disease requires close clinical follow up, morbidity and mortality in this case is not severe as in renal and the central nervous system involvement. ..
  46. Cho E, Choi Y, Chae S, Sohn J, Ahn G. Relationship between p53-associated proteins and estrogen receptor status in ovarian serous neoplasms. Int J Gynecol Cancer. 2006;16:1000-6 pubmed
  47. Gurbuz Y, Ozkara S. Immunohistochemical profile of serous papillary cystadenofibroma of the fallopian tube: a clue of paramesonephritic origin. Appl Immunohistochem Mol Morphol. 2003;11:153-5 pubmed
  48. Rattner D, Fernandez Del Castillo C, Warshaw A. Cystic pancreatic neoplasms. Ann Oncol. 1999;10 Suppl 4:104-6 pubmed
    ..When surgery is performed, benign lesions should be treated with pancreatic parenchymal sparing procedures if anatomy permits. Standard surgical oncologic principles should be employed when treating indeterminate or malignant lesions. ..
  49. Alaiya A, Franzen B, Moberger B, Silfversward C, Linder S, Auer G. Two-dimensional gel analysis of protein expression in ovarian tumors shows a low degree of intratumoral heterogeneity. Electrophoresis. 1999;20:1039-46 pubmed
    ..We conclude that 2-DE analysis of intratumoral heterogeneity in ovarian cancer tissue indicates a low degree of heterogeneity. ..
  50. Kloppel G, Kosmahl M. Cystic lesions and neoplasms of the pancreas. The features are becoming clearer. Pancreatology. 2001;1:648-55 pubmed
    ..The progress made in recent years has made it possible to clearly distinguish between the various entities and to unravel some of the problems involved. ..
  51. Exacoustos C, Romanini M, Rinaldo D, Amoroso C, Szabolcs B, Zupi E, et al. Preoperative sonographic features of borderline ovarian tumors. Ultrasound Obstet Gynecol. 2005;25:50-9 pubmed
    ..The most frequent diagnostic feature on imaging BOT is the presence of papillae within the cyst. However, neither papillae nor other sonographic features constituted highly sensitive sonographic markers of BOT. ..
  52. Okada S, Ohaki Y, Inoue K, Kawamura T, Hayashi T, Kato T, et al. Calcifications in mucinous and serous cystic ovarian tumors. J Nippon Med Sch. 2005;72:29-33 pubmed
    ..However, the presence of intramural calcifications may be a good indicator of mucinous tumors. Understanding the frequency and morphology of the calcifications in these neoplasms is one of the keys to making a correct diagnosis. ..
  53. Aranha G. Central (middle segment) pancreatectomy: a suitable operation for small lesions of the neck of the pancreas. Hepatogastroenterology. 2002;49:1713-5 pubmed
    ..Central pancreatectomy affords the opportunity to save normal pancreatic tissue thus avoiding the complications of exocrine pancreatic insufficiency, namely steatorrhea and endocrine pancreatic insufficiency namely diabetes...
  54. Liu A, Chen L, Ngan H, Khoo U, Zhao Y, Cheung A. Apoptotic and proliferative activity in ovarian benign, borderline and malignant tumors. Chin Med Sci J. 2002;17:106-11 pubmed
    ..To determine the apoptotic and proliferative activities in various ovarian epithelial tumors...
  55. Irie H, Honda H, Kuroiwa T, Yoshimitsu K, Aibe H, Shinozaki K, et al. Measurement of the apparent diffusion coefficient in intraductal mucin-producing tumor of the pancreas by diffusion-weighted echo-planar MR imaging. Abdom Imaging. 2002;27:82-7 pubmed
    ..We investigated whether diffusion-weighted echo-planar magnetic resonance (MR) imaging can help differentiate intraductal mucin-producing tumors of the pancreas from other cystic lesions...
  56. Li A, Elmore R, Pavelka J, Karlan B. Hyperandrogenism, mediated by obesity and receptor polymorphisms, promotes aggressive epithelial ovarian cancer biology. Gynecol Oncol. 2007;107:420-3 pubmed
    ..We have hypothesized that the combination of these factors further manifests an aggressive ovarian cancer phenotype...
  57. Kuroda N, Toi M, Nakayama H, Miyazaki E, Yamamoto M, Hayashi Y, et al. The distribution and role of myofibroblasts and CD34-positive stromal cells in normal pancreas and various pancreatic lesions. Histol Histopathol. 2004;19:59-67 pubmed publisher
    ..n=3), chronic non-obstructive pancreatitis (n=4), obstructive pancreatitis (n=7), islet cell tumor (n=4), serous cystadenoma (n=7), mucinous cystadenoma (n=6), and invasive ductal carcinoma (n=12)...
  58. Kikuchi A, Kozuma S, Yasugi T, Taketani Y. 3-D fractal tumor growth of epithelial ovarian cancer. Eur J Gynaecol Oncol. 2006;27:561-5 pubmed
    ..Our objective was to determine whether surface growth patterns in malignant epithelial ovarian tumors are 3-D fractal, and if the mean fractal dimension differs according to histologic types...
  59. Montero M, Vázquez J, Rihuete M, Cortón D, Antón L, Soriano D, et al. Serous cystadenoma of the pancreas in a child. J Pediatr Surg. 2003;38:E6-7 pubmed
    ..Only 4 of them represented serous cystadenoma. Although the tumor is not potentially malignant, all patients required partial pancreatic resection...
  60. Lee C, Scheiman J, Anderson M, Hines O, Reber H, Farrell J, et al. Risk of malignancy in resected cystic tumors of the pancreas < or =3 cm in size: is it safe to observe asymptomatic patients? A multi-institutional report. J Gastrointest Surg. 2008;12:234-42 pubmed
    ..3%. This study suggests that a group of patients with small cystic pancreatic neoplasms who have low risk of malignancy can be identified, and selective resection of these lesions may be appropriate...
  61. Slukvin I, Hafez G, Niederhuber J, Warner T. Combined serous microcystic adenoma and well-differentiated endocrine pancreatic neoplasm: a case report and review of the literature. Arch Pathol Lab Med. 2003;127:1369-72 pubmed
  62. Werlin L, Micha J, Rushovich A, Goldstein B. Serous cystadenoma and ectopic pregnancy in the fallopian tube. J Minim Invasive Gynecol. 2010;17:653-5 pubmed publisher
    ..The patient eventually underwent diagnostic laparoscopy. After pathologic review, an ectopic pregnancy and serous cystadenoma were identified in the left fallopian tube.
  63. Pedrazzoli S, Sperti C, Pasquali C. Pancreatic head resection for noninflammatory benign lesions of the head of the pancreas. Pancreas. 2001;23:309-15 pubmed
    ..Duodenum-preserving pancreatic head resection (DPPHR) has been safely performed in patients with chronic pancreatitis. The procedure has rarely been used to remove benign or borderline lesions of the head of the pancreas...
  64. Tulunay G, Baykal C, Cil A, Kahraman B, Ozer S, Cavusoglu D. Borderline tumor of the lymph node associated with bilateral serous borderline tumor of the ovary: case report. Eur J Gynaecol Oncol. 2004;25:632-4 pubmed
    ..At the same time, pathological examination of one of the paraaortic lymph nodes revealed borderline tumor of the lymph node. We also searched the literature associated with this case...
  65. Ebert A, Rosenow G, David M, Mechsner S, Magalov I, Papadopoulos T. Co-occurrence of atypical endometriosis, subserous uterine leiomyomata, sactosalpinx, serous cystadenoma and bilateral hemorrhagic corpora lutea in a perimenopausal adipose patient taking tamoxifen (20 mg/day) for invasive lobular breast cancer. Gynecol Obstet Invest. 2008;66:209-13 pubmed publisher
    ..For women taking tamoxifen, recent data strongly support the estrogen agonist role of tamoxifen as a causal factor for the increased risk of endometriosis, but also of leiomyomata, endometrial polyps, and endometrial hyperplasia...
  66. Ionescu M, Dumitrascu T, Stroescu C, Ciurea S, Pietrăreanu D, Mitulescu G, et al. [Central pancreatectomy--indications, technique, outcomes]. Chirurgia (Bucur). 2005;100:429-35 pubmed
    ..We report our experience on 5 patients and some considerations about this surgical technique from medical literature...
  67. Bardeesy N, Morgan J, Sinha M, Signoretti S, Srivastava S, Loda M, et al. Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia. Mol Cell Biol. 2002;22:635-43 pubmed
    ..These compound mutant mice developed a novel pancreatic neoplasm, serous cystadenoma (SCA), presenting as large epithelial tumors bearing conspicuous gross and histological resemblances to ..
  68. Stephens D, Pillai S, Cham E, Arensman R, Chou P. Serous borderline tumor of the fallopian tube in a patient with Klippel-Trenaunay syndrome. J Pediatr Surg. 2010;45:2244-6 pubmed publisher
    ..This case is notable for the rarity of this neoplasm in a premenarchal patient as well as the association with this syndrome. We briefly review these entities and the significance of malignancy in Klippel-Trenaunay syndrome...
  69. Saldaña D, de Acosta D, Alemán H, Gebrehiwot D, Torres E. Gallbladder endometrioma associated with obstructive jaundice and a serous ovarian cystic adenoma. South Med J. 2010;103:1250-2 pubmed publisher
    ..Endometriosis should be considered in the differential diagnosis of a fertile woman with a painful mass, particularly if the mass is associated in size and tenderness with menstrual variability...
  70. Zeng L, Peng Z, Duan Z. [Expression of THY1 gene in epithelial ovarian cancer]. Zhonghua Zhong Liu Za Zhi. 2009;31:118-20 pubmed
    ..To detect the expession of THY1 in ovarian serous cystadenocarcinoma tissues...
  71. Roger P, Pujol P, Lucas A, Baldet P, Rochefort H. Increased immunostaining of fibulin-1, an estrogen-regulated protein in the stroma of human ovarian epithelial tumors. Am J Pathol. 1998;153:1579-88 pubmed
    ..This fibulin-1 overexpression, demonstrated in vivo in ovarian carcinomas, might be a useful indicator for predicting cancer risk and/or aggressiveness...
  72. Machado M, Machado M. Solid serous adenoma of the pancreas: an uncommon but important entity. Eur J Surg Oncol. 2008;34:730-3 pubmed publisher
    ..It is definitively a rare entity but oncologic surgeons should be aware of this neoplasm in order to make a correct preoperative diagnosis that will ultimately result in more conservative surgeries...
  73. Rao S, Zeng M, Cheng W, Yang S, Miao X, Zhang L, et al. [Value of multidetector computed tomography in differentiating ovarian tumors from non-ovarian masses]. Zhonghua Zhong Liu Za Zhi. 2007;29:856-9 pubmed
    ..To evaluate the ability of multidetector computed tomography (MDCT) in differentiating ovarian tumors from non-ovarian masses...
  74. Ashkzaran H, Coenegrachts K, Steyaert L, Vandelanotte M, Van den Berghe I, Verstraete K, et al. An unusual presentation of pancreatic serous cystadenoma with acute hemorrhage. JBR-BTR. 2007;90:44-6 pubmed
    ..They can be discovered after investigations for upper abdominal discomfort because of mass effect or incidentally. In rare cases they are detected because of biliary obstruction. Hemorrhagic complication is very unusual...
  75. Abdullah L, Gupta R, Arnst A. Intratesticular borderline serous tumor. Int J Urol. 2006;13:1536-8 pubmed
    ..We report a case of an intratesticular borderline serous tumor accidentally discovered during the course of a preoperative workup in a 72-year-old man admitted for left upper lobectomy for squamous cell carcinoma of the lung...
  76. Sand J, Nordback I. The differentiation between pancreatic neoplastic cysts and pancreatic pseudocyst. Scand J Surg. 2005;94:161-4 pubmed
    ..Endoscopic ultrasound, cyst fluid analysis and positron emission tomography may be used in selected patients, but the accuracy of these methods needs further investigation...
  77. Bassi C, Salvia R, Gumbs A, Butturini G, Falconi M, Pederzoli P. The value of standard serum tumor markers in differentiating mucinous from serous cystic tumors of the pancreas: CEA, Ca 19-9, Ca 125, Ca 15-3. Langenbecks Arch Surg. 2002;387:281-5 pubmed
    ..Examination of preoperative serum tumor markers may help improve preoperative diagnosis...
  78. Talmon G, Johannson S. Serous cystadenoma of the epididymis. Urology. 2007;70:372.e7-8 pubmed
    ..The latter are most commonly serous tumors of borderline malignant potential and involve the tunicae. We present the first case of a serous cystadenoma of the epididymis in English reports with a brief literature review.
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    ..Here we explored whether glycosylation variants on specific proteins in cyst fluid samples could serve as biomarkers to aid in this diagnosis...
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    ..In this review, we summarize the recent publications that have examined the key issues in the diagnosis and management of cystic lesions of the pancreas...
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    ..To evaluate the series of advanced ovarian cancer patients who underwent splenectomy as part of their surgery, a retrospective file review of 258 ovarian cancer cases were examined...