adenoma

Summary

Summary: A benign epithelial tumor with a glandular organization.

Top Publications

  1. Yamaji T, Iwasaki M, Sasazuki S, Sakamoto H, Yoshida T, Tsugane S. Association between plasma 25-hydroxyvitamin D and colorectal adenoma according to dietary calcium intake and vitamin D receptor polymorphism. Am J Epidemiol. 2012;175:236-44 pubmed publisher
    ..examinees who underwent total colonoscopy in Tokyo, Japan, 2004-2005, and evaluated its influence on colorectal adenoma, both alone and in interaction with VDR polymorphisms, which correspond to the FokI and TaqI restriction sites...
  2. Morgan R, Hernández Ramírez L, Trivellin G, Zhou L, Roe S, Korbonits M, et al. Structure of the TPR domain of AIP: lack of client protein interaction with the C-terminal α-7 helix of the TPR domain of AIP is sufficient for pituitary adenoma predisposition. PLoS ONE. 2012;7:e53339 pubmed publisher
    ..suggesting that failure of client-protein interaction with the Cα-7h is sufficient to predispose to pituitary adenoma. We have also identified a molecular switch in the AIP TPR-domain that allows recognition of both the conserved ..
  3. Palles C, Cazier J, Howarth K, Domingo E, Jones A, Broderick P, et al. Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas. Nat Genet. 2013;45:136-44 pubmed publisher
    ..and association analysis, we identified specific heterozygous POLE or POLD1 germline variants in several multiple-adenoma and/or CRC cases but in no controls. The variants associated with susceptibility, POLE p.Leu424Val and POLD1 p...
  4. Voutsinas J, Wilkens L, Franke A, Vogt T, Yokochi L, Decker R, et al. Heterocyclic amine intake, smoking, cytochrome P450 1A2 and N-acetylation phenotypes, and risk of colorectal adenoma in a multiethnic population. Gut. 2013;62:416-22 pubmed publisher
    ..This study tested the hypotheses that well-done meat and cigarette smoking increase the risk of adenoma, the precursor to most colorectal cancers, especially in individuals with rapid CYP1A2 and rapid NAT2 activities...
  5. Lee S, Kang S, Cho J, Lee B, Chang D, Woo H, et al. Pyloric gland adenoma in Lynch syndrome. Am J Surg Pathol. 2014;38:784-92 pubmed publisher
    ..Remarkably, in a patient with LS and germline mutation of MLH1 gene, pyloric gland adenoma (PGA) transformed to adenocarcinoma during follow-up...
  6. Gollub M, Grewal R, Panu N, Thipphavong S, Sohn M, Zheng J, et al. Diagnostic accuracy of ¹?F-FDG PET/CT for detection of advanced colorectal adenoma. Clin Radiol. 2014;69:611-8 pubmed publisher
    ..To determine the accuracy of 2-[(18)F]-fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography (PET) in the detection of advanced colorectal adenomas...
  7. Corley D, Jensen C, Marks A, Zhao W, Lee J, Doubeni C, et al. Adenoma detection rate and risk of colorectal cancer and death. N Engl J Med. 2014;370:1298-306 pubmed publisher
    ..proportion of screening colonoscopic examinations performed by a physician that detect one or more adenomas (the adenoma detection rate) is a recommended quality measure...
  8. Shrubsole M, Cai Q, Wen W, Milne G, Smalley W, Chen Z, et al. Urinary prostaglandin E2 metabolite and risk for colorectal adenoma. Cancer Prev Res (Phila). 2012;5:336-42 pubmed publisher
    ..Urinary PGE-M was assessed in a case-control study of colorectal adenoma. Included in the analysis were 224 cases with at least one advanced adenoma, 152 cases with multiple small ..
  9. Vyas S, Skipworth J, Lytras D, Smyth C, Mee A, Hatfield A, et al. Rare presentation of Brunner's gland adenoma: another differentiation in patients with recurrent "idiopathic" pancreatitis. Hepatobiliary Pancreat Dis Int. 2012;11:107-10 pubmed
    Brunner's gland adenoma (BGA) is an unusual benign neoplasm arising from Brunner's glands in the duodenum. When symptomatic it presents either with duodenal obstruction or bleeding...

More Information

Publications105 found, 100 shown here

  1. Zauber A, Winawer S, O Brien M, Lansdorp Vogelaar I, van Ballegooijen M, Hankey B, et al. Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths. N Engl J Med. 2012;366:687-96 pubmed publisher
    ..2; 95% CI, 0.1 to 10.6). These findings support the hypothesis that colonoscopic removal of adenomatous polyps prevents death from colorectal cancer. (Funded by the National Cancer Institute and others.). ..
  2. Rosa I, Fidalgo P, Soares J, Vinga S, Oliveira C, Silva J, et al. Adenoma incidence decreases under the effect of polypectomy. World J Gastroenterol. 2012;18:1243-8 pubmed publisher
    To investigate whether, under the influence of polypectomy, the incidence of adenoma decreases with age...
  3. Chiong C, Cox M, Eslick G. Gallstones are associated with colonic adenoma: a meta-analysis. World J Surg. 2012;36:2202-9 pubmed publisher
    ..It remains unclear whether there is a similar risk of developing adenomas. The aim of this meta-analysis was to determine the risk of developing colonic adenomas following gallstone disease or cholecystectomy...
  4. Gurudu S, Ramirez F, Harrison M, Leighton J, Crowell M. Increased adenoma detection rate with system-wide implementation of a split-dose preparation for colonoscopy. Gastrointest Endosc. 2012;76:603-8.e1 pubmed publisher
    ..However, the effects of SDP on other quality indicators of colonoscopy, such as cecal intubation and adenoma detection rates, have not been previously reported, to our knowledge...
  5. Park S, Kim T, Yoon J, Kim T, Chung J, Jeon U, et al. The washout rate on the delayed CT image as a diagnostic tool for adrenal adenoma verified by pathology: a multicenter study. Int Urol Nephrol. 2012;44:1397-402 pubmed publisher
    To establish the undisputed the value of washout rate for adrenal adenoma using delayed enhanced CT, we evaluated diagnostic performance of cut-off value and delayed time of washout rate by final pathologic diagnosis in a multicenter ..
  6. Cui G, Yuan A, Goll R, Florholmen J. IL-17A in the tumor microenvironment of the human colorectal adenoma-carcinoma sequence. Scand J Gastroenterol. 2012;47:1304-12 pubmed publisher
    ..authors evaluated the dynamic change of IL-17A expression in the tumor microenvironment throughout the colorectal adenoma-carcinoma sequence...
  7. Gentilin E, Tagliati F, Filieri C, Molè D, Minoia M, Rosaria Ambrosio M, et al. miR-26a plays an important role in cell cycle regulation in ACTH-secreting pituitary adenomas by modulating protein kinase C?. Endocrinology. 2013;154:1690-700 pubmed publisher
    ..as putative therapeutic targets; their investigation may shed light on the mechanisms that underpin pituitary adenoma development and progression...
  8. Boroff E, Gurudu S, Hentz J, Leighton J, Ramirez F. Polyp and adenoma detection rates in the proximal and distal colon. Am J Gastroenterol. 2013;108:993-9 pubmed publisher
    Little is known about the correlation between the polyp detection rate (PDR) and the adenoma detection rate (ADR) in individual colonic segments...
  9. Van Udelsman B, Udelsman R. Surgery in primary hyperparathyroidism: extensive personal experience. J Clin Densitom. 2013;16:54-9 pubmed publisher
    ..This article reviews our approach reflecting advances in preoperative localization, anesthetic techniques, and intraoperative management of patients undergoing parathyroidectomy for the treatment of PHPT...
  10. Javanbakht J, Tavassoli A, Sasani F, Sabbagh A, Hassan M, Samakkhah S, et al. An overall assessment of circumanal gland adenoma in a terrier mix breed dog. Asian Pac J Trop Biomed. 2013;3:580-3 pubmed publisher
    ..Ulceration, hemorrhage, necrosis and secondary infection with inflammatory cell infiltrates are common. These cytology and histopathology features are consistent with hepatoid gland adenoma.
  11. Varshney S, Bhadada S, Sachdeva N, Arya A, Saikia U, Behera A, et al. Methylation status of the CpG islands in vitamin D and calcium-sensing receptor gene promoters does not explain the reduced gene expressions in parathyroid adenomas. J Clin Endocrinol Metab. 2013;98:E1631-5 pubmed publisher
    ..decreased expression of the vitamin D receptor (VDR) and calcium-sensing receptor (CASR) genes in parathyroid adenoma is not known, but methylation of promoter regions is often detected during epigenetic downregulation of gene ..
  12. Stratakis C. Cushing syndrome in pediatrics. Endocrinol Metab Clin North Am. 2012;41:793-803 pubmed publisher
    ..Barriers to optimal care of a pediatric patient with Cushing syndrome are discussed. ..
  13. Cai Q, Yu E, Xiao Y, Bai W, Chen X, He L, et al. Derivation and validation of a prediction rule for estimating advanced colorectal neoplasm risk in average-risk Chinese. Am J Epidemiol. 2012;175:584-93 pubmed publisher
    No prediction rule is currently available for advanced colorectal neoplasms, defined as invasive cancer, an adenoma of 10 mm or more, a villous adenoma, or an adenoma with high-grade dysplasia, in average-risk Chinese...
  14. Coriat R, Lecler A, Lamarque D, Deyra J, Roche H, Nizou C, et al. Quality indicators for colonoscopy procedures: a prospective multicentre method for endoscopy units. PLoS ONE. 2012;7:e33957 pubmed publisher
    ..Colon preparation was insufficient in 3.7% (range 1-10.5). Colonoscopies were successful in 95.3% (range 81-99). Adenoma detection rate was 0.31 (range 0.17-0.45) in successful colonoscopies...
  15. Schepers A, Snippert H, Stange D, van den Born M, van Es J, van de Wetering M, et al. Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science. 2012;337:730-5 pubmed publisher
    ..heterotrimeric guanine nucleotide-binding protein-coupled receptor 5) also marks a subpopulation of adenoma cells that fuel the growth of established intestinal adenomas...
  16. Jiang Z, Gui S, Zhang Y. Analysis of differential gene expression in plurihormonal pituitary adenomas using bead-based fiber-optic arrays. J Neurooncol. 2012;108:341-8 pubmed publisher
    ..Bead-based fiber-optic arrays combined with pathway analysis of gene expression data appears to be a valid method for investigating the pathogenesis of tumors...
  17. Matsubara A, Sekine S, Kushima R, Ogawa R, Taniguchi H, Tsuda H, et al. Frequent GNAS and KRAS mutations in pyloric gland adenoma of the stomach and duodenum. J Pathol. 2013;229:579-87 pubmed publisher
    ..of microsatellite instability, was observed in one PGA (3%), 12 foveolar-type adenomas (52%), one intestinal-type adenoma (2%) and five adenocarcinomas (7%)...
  18. Teriaky A, Driman D, Chande N. Outcomes of a 5-year follow-up of patients with sessile serrated adenomas. Scand J Gastroenterol. 2012;47:178-83 pubmed publisher
    ..SSAs occurred more frequently in females and in the right colon. Dysplasia occurred in a small subset of SSAs. There was a high rate of prior and subsequent CRC in patients with SSAs. ..
  19. Wang M, Mou C, Jiang M, Han L, Fan S, Huan C, et al. The characteristics of acromegalic patients with hyperprolactinemia and the differences in patients with merely GH-secreting adenomas: clinical analysis of 279 cases. Eur J Endocrinol. 2012;166:797-802 pubmed publisher
  20. Adler A, Wegscheider K, Lieberman D, Aminalai A, Aschenbeck J, Drossel R, et al. Factors determining the quality of screening colonoscopy: a prospective study on adenoma detection rates, from 12,134 examinations (Berlin colonoscopy project 3, BECOP-3). Gut. 2013;62:236-41 pubmed publisher
    Screening colonoscopy (SC) outcome quality is best determined by the adenoma detection rate (ADR). The substantial variability in the ADRs between endoscopists may reflect different skills, experience and/or equipment...
  21. Lee J, Kim J, Lee S, Quinley C, Kim H, Herdman S, et al. Signal transducer and activator of transcription 3 (STAT3) protein suppresses adenoma-to-carcinoma transition in Apcmin/+ mice via regulation of Snail-1 (SNAI) protein stability. J Biol Chem. 2012;287:18182-9 pubmed publisher
    ..Accordingly, the tumors in Apc(min)(/+)/Stat3(IEC-KO) mice undergo adenoma-to-carcinoma transition and acquire an invasive phenotype...
  22. Littlejohn C, Hilton S, Macfarlane G, Phull P. Systematic review and meta-analysis of the evidence for flexible sigmoidoscopy as a screening method for the prevention of colorectal cancer. Br J Surg. 2012;99:1488-500 pubmed publisher
    ..of FS was usually lower than that for stool-based tests, although FS was more effective at detecting advanced adenoma and carcinoma...
  23. Choueiri T, Cheville J, Palescandolo E, Fay A, Kantoff P, Atkins M, et al. BRAF mutations in metanephric adenoma of the kidney. Eur Urol. 2012;62:917-22 pubmed publisher
    Metanephric adenoma (MA) of the kidney is a rare, indolent tumor that may be difficult to differentiate from other small renal masses (SRMs). Genetic alterations associated with MA remain largely unknown...
  24. Mohammadi M, Kristensen M, Nielsen H, Bonde J, Holck S. Qualities of sessile serrated adenoma/polyp/lesion and its borderline variant in the context of synchronous colorectal carcinoma. J Clin Pathol. 2012;65:924-7 pubmed
    Although much data have accumulated on sessile serrated adenoma/polyp/lesion (SSA/P/L) in general, its characteristics in specified contexts are less well elucidated...
  25. Kim H, Kim Y, Kang Y, Moon J. Leptin and peroxisome proliferator-activated receptor ? expression in colorectal adenoma. World J Gastroenterol. 2012;18:557-62 pubmed publisher
    ..BMI has influenced on the leptin expression of colorectal adenoma. The exact mechanism underlies the strong correlation between leptin and PPARG expression needs further study.
  26. Boguszewski C, Fighera T, Bornschein A, Marques F, Dénes J, Rattenbery E, et al. Genetic studies in a coexistence of acromegaly, pheochromocytoma, gastrointestinal stromal tumor (GIST) and thyroid follicular adenoma. Arq Bras Endocrinol Metabol. 2012;56:507-12 pubmed
    ..pheochromocytoma (PHEO), gastrointestinal stromal tumor (GIST), intestinal polyposis, and thyroid follicular adenoma. At the age of 56, she was diagnosed with acromegaly caused by a pituitary macroadenoma, treated by ..
  27. Wang J, Wang X, Lin S, Chen C, Wang C, Ma Q, et al. Identification of kininogen-1 as a serum biomarker for the early detection of advanced colorectal adenoma and colorectal cancer. PLoS ONE. 2013;8:e70519 pubmed publisher
    ..Proteomic profiles of serum samples collected from 35 healthy volunteers, 35 patients with advanced colorectal adenoma (ACA), and 40 patients with CRC were compared using Clinprot technology...
  28. Aswakul P, Prachayakul V, Lohsiriwat V, Bunyaarunnate T, Kachintorn U. Screening colonoscopy from a large single center of Thailand - something needs to be changed?. Asian Pac J Cancer Prev. 2012;13:1361-4 pubmed
    Results of screening colonoscopy from Western countries reported adenoma detection rates (ADRs) of 30-40% while those from Asia had ADR as low as 10%. There have been limited data regarding screening colonoscopy in Thailand...
  29. Schwitalla S, Ziegler P, Horst D, Becker V, Kerle I, Begus Nahrmann Y, et al. Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors. Cancer Cell. 2013;23:93-106 pubmed publisher
    Loss of p53 is considered to allow progression of colorectal tumors from the adenoma to the carcinoma stage...
  30. Prasetyanti P, Zimberlin C, De Sousa E Melo F, Medema J. Isolation and propagation of colon cancer stem cells. Methods Mol Biol. 2013;1035:247-59 pubmed publisher
    ..we describe a detailed methodology for the isolation and expansion of both human colon CSCs and mouse intestinal adenoma together with a brief differentiation and coculture method that proved to be valuable to study the concept of ..
  31. Carvalho B, Sillars Hardebol A, Postma C, Mongera S, Terhaar sive Droste J, Obulkasim A, et al. Colorectal adenoma to carcinoma progression is accompanied by changes in gene expression associated with ageing, chromosomal instability, and fatty acid metabolism. Cell Oncol (Dordr). 2012;35:53-63 pubmed publisher
    ..Colorectal cancer develops in a multi-step manner from normal epithelium, through a pre-malignant lesion (so-called adenoma), into a malignant lesion (carcinoma), which invades surrounding tissues and eventually can spread systemically (..
  32. Burnett Hartman A, Newcomb P, Phipps A, Passarelli M, Grady W, Upton M, et al. Colorectal endoscopy, advanced adenomas, and sessile serrated polyps: implications for proximal colon cancer. Am J Gastroenterol. 2012;107:1213-9 pubmed publisher
  33. Grimm C, Chavez L, Vilardell M, Farrall A, Tierling S, Böhm J, et al. DNA-methylome analysis of mouse intestinal adenoma identifies a tumour-specific signature that is partly conserved in human colon cancer. PLoS Genet. 2013;9:e1003250 pubmed publisher
    ..Here, we have used MeDIP-seq to analyse the DNA methylome of APC(Min) adenoma as a model for intestinal cancer initiation, and we present a list of more than 13,000 recurring differentially ..
  34. Lekva T, Berg J, Fougner S, Olstad O, Ueland T, Bollerslev J. Gene expression profiling identifies ESRP1 as a potential regulator of epithelial mesenchymal transition in somatotroph adenomas from a large cohort of patients with acromegaly. J Clin Endocrinol Metab. 2012;97:E1506-14 pubmed publisher
  35. Al Kharusi M, Smartt H, Greenhough A, Collard T, Emery E, Williams A, et al. LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: implications for targeting adenoma stem cells with NSAIDs. Carcinogenesis. 2013;34:1150-7 pubmed publisher
    ..Wnt signalling, the focus of this study was to investigate whether PGE2 regulated LGR5 expression in colorectal adenoma cells and whether LGR5 was important for tumour cell survival...
  36. Chokshi R, Hovis C, Hollander T, Early D, Wang J. Prevalence of missed adenomas in patients with inadequate bowel preparation on screening colonoscopy. Gastrointest Endosc. 2012;75:1197-203 pubmed publisher
    ..Initial adenoma detection rate and adenoma detection rate on follow-up examination...
  37. Jover R, Zapater P, Polanía E, Bujanda L, Lanas A, Hermo J, et al. Modifiable endoscopic factors that influence the adenoma detection rate in colorectal cancer screening colonoscopies. Gastrointest Endosc. 2013;77:381-389.e1 pubmed publisher
    b>Adenoma detection rate (ADR) has become the most important quality indicator for colonoscopy...
  38. Logan R, Patnick J, Nickerson C, Coleman L, Rutter M, von Wagner C. Outcomes of the Bowel Cancer Screening Programme (BCSP) in England after the first 1 million tests. Gut. 2012;61:1439-46 pubmed
    ..Subjects aged 60-69 are being invited to complete three guaiac faecal occult blood tests (6 windows) every 2 years. The programme aims to reduce mortality from colorectal cancer by 16% in those invited for screening...
  39. Xekouki P, Pacak K, Almeida M, Wassif C, Rustin P, Nesterova M, et al. Succinate dehydrogenase (SDH) D subunit (SDHD) inactivation in a growth-hormone-producing pituitary tumor: a new association for SDH?. J Clin Endocrinol Metab. 2012;97:E357-66 pubmed publisher
  40. Kimura T, Yamamoto E, Yamano H, Suzuki H, Kamimae S, Nojima M, et al. A novel pit pattern identifies the precursor of colorectal cancer derived from sessile serrated adenoma. Am J Gastroenterol. 2012;107:460-9 pubmed publisher
    ..Consequently, colonoscopic identification of SSAs has important implications for preventing CRCs, but accurate endoscopic diagnosis is often difficult. Our aim was to clarify which endoscopic findings are specific to SSAs...
  41. Lee Y, Jun H, Pan C, Lin S, Wilson L, Mansfield B, et al. Prevention of hepatocellular adenoma and correction of metabolic abnormalities in murine glycogen storage disease type Ia by gene therapy. Hepatology. 2012;56:1719-29 pubmed publisher
    ..type Ia (GSD-Ia), which is characterized by impaired glucose homeostasis and chronic risk of hepatocellular adenoma (HCA), is caused by deficiencies in the endoplasmic reticulum (ER)-associated glucose-6-phosphatase-? (G6Pase-? ..
  42. Hong J, Ding X, Wang S. Coexistence of ectopic pituitary adenoma and empty sella in a patient with acromegaly : a case report and review of literature. Neurol India. 2012;60:304-6 pubmed publisher
    Ectopic pituitary adenoma with an empty sella is extremely rare. We report an unusual patient with an ectopic growth hormone-secreting pituitary adenoma in the sphenoid sinus with an empty sella...
  43. Atkin W, Valori R, Kuipers E, Hoff G, Senore C, Segnan N, et al. European guidelines for quality assurance in colorectal cancer screening and diagnosis. First Edition--Colonoscopic surveillance following adenoma removal. Endoscopy. 2012;44 Suppl 3:SE151-63 pubmed
    ..The chapter on colonoscopic surveillance following adenoma removal includes 24 graded recommendations...
  44. Rossitto G, Regolisti G, Rossi E, Negro A, Nicoli D, Casali B, et al. Elevation of angiotensin-II type-1-receptor autoantibodies titer in primary aldosteronism as a result of aldosterone-producing adenoma. Hypertension. 2013;61:526-33 pubmed publisher
    ..Moreover, if they were elevated in aldosterone-producing adenoma (APA) and not in idiopathic hyperaldosteronism (IHA), they might be useful for discriminating between these ..
  45. Lee T, Blanks R, Rees C, Wright K, Nickerson C, Moss S, et al. Longer mean colonoscopy withdrawal time is associated with increased adenoma detection: evidence from the Bowel Cancer Screening Programme in England. Endoscopy. 2013;45:20-6 pubmed publisher
    Increasing colonoscopy withdrawal time (CWT) is thought to be associated with increasing adenoma detection rate (ADR). Current English guidelines recommend a minimum CWT of 6 minutes...
  46. Bricaire L, Odou M, Cardot Bauters C, Delemer B, North M, Salenave S, et al. Frequent large germline HRPT2 deletions in a French National cohort of patients with primary hyperparathyroidism. J Clin Endocrinol Metab. 2013;98:E403-8 pubmed publisher
    ..is an autosomal dominant syndrome with incomplete penetrance that can associate in a single patient parathyroid adenoma or carcinoma, fibro-osseous jaw tumor, cystic kidney lesion, and uterine tumor...
  47. Yen A, Leung J, Leung F. A novel method with significant impact on adenoma detection: combined water-exchange and cap-assisted colonoscopy. Gastrointest Endosc. 2013;77:944-8 pubmed publisher
    Water exchange provides salvage cleansing and improves adenoma detection, but drawbacks include prolonged procedure time...
  48. Prasetyanti P, Zimberlin C, Bots M, Vermeulen L, Melo F, Medema J. Regulation of stem cell self-renewal and differentiation by Wnt and Notch are conserved throughout the adenoma-carcinoma sequence in the colon. Mol Cancer. 2013;12:126 pubmed publisher
    ..This suggests that, despite the numerous genetic aberrations and morphological changes that have occurred during cancer initiation and progression, a remnant homeostatic regulation persists...
  49. van Heumen B, Roelofs H, Te Morsche R, Marian B, Nagengast F, Peters W. Celecoxib and tauro-ursodeoxycholic acid co-treatment inhibits cell growth in familial adenomatous polyposis derived LT97 colon adenoma cells. Exp Cell Res. 2012;318:819-27 pubmed publisher
    ..HT-29 colon cancer cells and LT97 colorectal micro-adenoma cells derived from a patient with FAP, were exposed to low dose celecoxib and UDCA alone or in combination with ..
  50. Kim B, Shin A, Hong C, Sohn D, Han K, Ryu K, et al. Association of colorectal adenoma with components of metabolic syndrome. Cancer Causes Control. 2012;23:727-35 pubmed publisher
    ..The objective of this study was to assess the association between metabolic risk factors and colorectal neoplasm...
  51. Pan Y, Han C, Wang C, Hu G, Luo C, Gan X, et al. ADAM10 promotes pituitary adenoma cell migration by regulating cleavage of CD44 and L1. J Mol Endocrinol. 2012;49:21-33 pubmed publisher
    ..In high-grade pituitary adenoma patients, ADAM10 expression levels were found to be elevated compared with low-grade pituitary adenomas...
  52. Yoo J, Shin S, Lee K, Choi J, Wi J, Kim D, et al. How can we predict the presence of missed synchronous lesions after endoscopic submucosal dissection for early gastric cancers or gastric adenomas?. J Clin Gastroenterol. 2013;47:e17-22 pubmed publisher
    To identify predictive factors associated with the presence of missed synchronous lesions after endoscopic submucosal dissection (ESD) for gastric adenoma or early gastric cancer (EGC).
  53. Bhangu A, Bowley D, Horner R, Baranowski E, Raman S, Karandikar S. Volume and accreditation, but not specialty, affect quality standards in colonoscopy. Br J Surg. 2012;99:1436-44 pubmed publisher
    ..There are known variations in colonoscopic performance, and investigation of factors causing this is needed. This study aimed to analyse the impact of endoscopist specialty and procedural volume on the quality of colonoscopy...
  54. Grivennikov S, Wang K, Mucida D, Stewart C, Schnabl B, Jauch D, et al. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature. 2012;491:254-8 pubmed publisher
    ..We propose that barrier deterioration induced by colorectal-cancer-initiating genetic lesions results in adenoma invasion by microbial products that trigger tumour-elicited inflammation, which in turn drives tumour growth.
  55. Zhou D, Yang L, Zheng L, Ge W, Li D, Zhang Y, et al. Exome capture sequencing of adenoma reveals genetic alterations in multiple cellular pathways at the early stage of colorectal tumorigenesis. PLoS ONE. 2013;8:e53310 pubmed publisher
    ..Sequencing the whole exome of the adenoma will help identifying molecular biomarkers that can predict the occurrence of adenocarcinoma more precisely and ..
  56. Lim J, Cha J, Lee J, Joo K, Shin H, Park J, et al. Osteoporosis is associated with the risk of colorectal adenoma in women. Dis Colon Rectum. 2013;56:169-74 pubmed publisher
    ..An association between lower bone mineral density and colorectal cancer suggests that colorectal adenoma, which is a precursor of colorectal cancer, may also be associated with lower bone mineral density.
  57. Raju G, Vadyala V, Slack R, Krishna S, Ross W, Lynch P, et al. Adenoma detection in patients undergoing a comprehensive colonoscopy screening. Cancer Med. 2013;2:391-402 pubmed publisher
    Measures shown to improve the adenoma detection during colonoscopy (excellent bowel preparation, cecal intubation, cap fitted colonoscope to examine behind folds, patient position change to optimize colon distention, trained endoscopy ..
  58. Marinoni I, Lee M, Mountford S, Perren A, Bravi I, Jennen L, et al. Characterization of MENX-associated pituitary tumours. Neuropathol Appl Neurobiol. 2013;39:256-69 pubmed publisher
    ..Characterization of MENX adenomas is a prerequisite to exploit this animal model for molecular and translational studies of pituitary adenomas...
  59. Liu J, Ding D, Wang X, Chen Y, Li R, Zhang Y, et al. N-acetyltransferase polymorphism and risk of colorectal adenoma and cancer: a pooled analysis of variations from 59 studies. PLoS ONE. 2012;7:e42797 pubmed publisher
    ..2 (NAT2) genotypes may be implicated in the development of colorectal cancer (CRC) and colorectal adenoma (CRA). So far the published data on this association has remained controversial, however...
  60. van Heijningen E, Lansdorp Vogelaar I, Kuipers E, Dekker E, Lesterhuis W, ter Borg F, et al. Features of adenoma and colonoscopy associated with recurrent colorectal neoplasia based on a large community-based study. Gastroenterology. 2013;144:1410-8 pubmed publisher
    We investigated adenoma and colonoscopy characteristics that are associated with recurrent colorectal neoplasia based on data from community-based surveillance practice.
  61. Ding W, Zhou D, Jiang X, Lu L. Methionine synthase A2756G polymorphism and risk of colorectal adenoma and cancer: evidence based on 27 studies. PLoS ONE. 2013;8:e60508 pubmed publisher
    ..concentrations, was thought to be involved in the development of colorectal cancer (CRC) and colorectal adenoma (CRA) by affecting DNA methylation...
  62. Tudorancea A, Francois P, Trouillas J, Cottier J, Girard J, Jan M, et al. Von Hippel-Lindau disease and aggressive GH-PRL pituitary adenoma in a young boy. Ann Endocrinol (Paris). 2012;73:37-42 pubmed publisher
    ..Pituitary adenomas are not classically described in VHL syndrome and the medical community should be alerted to its rare occurrence in this location...
  63. Pox C, Altenhofen L, Brenner H, Theilmeier A, Von Stillfried D, Schmiegel W. Efficacy of a nationwide screening colonoscopy program for colorectal cancer. Gastroenterology. 2012;142:1460-7.e2 pubmed publisher
    ..In autumn 2002, colonoscopy was introduced as part of a nationwide cancer screening program in Germany; it was offered to the general population for individuals 55 years of age or older. We collected and analyzed data from this program...
  64. Messick C, Church J, Bennett A, Kalady M. Serrated polyps: new classifications highlight clinical importance. Colorectal Dis. 2012;14:1328-37 pubmed publisher
    ..The clinical relevance of this new nomenclature is incompletely defined. This study examines the incidence and characteristics of colorectal SSA/Ps and describes other associated colorectal neoplasia...
  65. Voorham Q, Carvalho B, Spiertz A, van Grieken N, Mongera S, Rondagh E, et al. Chromosome 5q loss in colorectal flat adenomas. Clin Cancer Res. 2012;18:4560-9 pubmed
    ..Here, we aimed to compare one of the molecular changes most explicitly associated with adenoma to carcinoma progression, that is, chromosomal instability, between flat and polypoid colorectal adenomas.
  66. Lee K, Yum K. Association of endotoxins and colon polyp: a case-control study. J Korean Med Sci. 2012;27:1062-5 pubmed publisher
    ..149 ± 0.223 EU/mL). The endotoxin levels also significantly increased in groups with tubular adenoma with high-grade dysplasia (hyperplastic polyp group, 0.109 ± 0...
  67. Yüce S, Uysal I, Doğan M, Ersin T, Muderris S. Canalicular adenoma of the palate. J Craniofac Surg. 2012;23:e396-8 pubmed publisher
    ..Differential diagnosis of the canalicular adenoma versus adenocarcinoma is important because it may result in unjustified radiotherapy or extensive and aggressive ..
  68. Ben Q, An W, Jiang Y, Zhan X, Du Y, Cai Q, et al. Body mass index increases risk for colorectal adenomas based on meta-analysis. Gastroenterology. 2012;142:762-72 pubmed publisher
    ..the relationship between excess body weight, expressed as increased body mass index (BMI), and risk of colorectal adenoma (CRA). We conducted a meta-analysis to explore this relationship...
  69. Han S, Sue L, Berndt S, Selhub J, Burdette L, Rosenberg P, et al. Associations between genes in the one-carbon metabolism pathway and advanced colorectal adenoma risk in individuals with low folate intake. Cancer Epidemiol Biomarkers Prev. 2012;21:417-27 pubmed publisher
    ..Low dietary and circulating folate and polymorphic variation in this pathway are associated with increased risk of colorectal adenoma and cancer.
  70. Hongmei Y, Zhe W, Jing W, Daokui W, Peicheng C, Yongjie L. Delayed cerebrospinal fluid rhinorrhea after gamma knife surgery in a patient with a growth hormone-secreting adenoma. J Clin Neurosci. 2012;19:900-2 pubmed publisher
    ..cerebrospinal fluid (CSF) rhinorrhea 11 years after gamma knife radiosurgery for a growth hormone (GH)-secreting adenoma. The treatment dose was 18 Gy for the tumor margin (50% isodose)...
  71. Kwagyan J, Apprey V, Ashktorab H. Linkage disequilibrium and haplotype analysis of COX-2 and risk of colorectal adenoma development. Clin Transl Sci. 2012;5:60-4 pubmed publisher
    ..and haplotype analyses of 13 single nucleotide polymorphisms of the COX-2 gene and examined its susceptibility to adenoma development in 72 African American cases and 142 controls...
  72. Gupta N, Bansal A, Rao D, Early D, Jonnalagadda S, Wani S, et al. Prevalence of advanced histological features in diminutive and small colon polyps. Gastrointest Endosc. 2012;75:1022-30 pubmed publisher
    ..Advanced histological features such as villous histology, high-grade dysplasia, and/or cancer in these polyps could deter adoption of these strategies...
  73. Abulkheir I, Mohammad D. Value of immunohistochemical expression of p27 and galectin-3 in differentiation between follicular adenoma and follicular carcinoma. Appl Immunohistochem Mol Morphol. 2012;20:131-40 pubmed
    ..Galectin-3 is a member of lectin family and seems to play a significant role in a number of biological processes. p27 is a key regulator of progression from G1 to S phase...
  74. Bongers G, Muniz L, Pacer M, Iuga A, Thirunarayanan N, Slinger E, et al. A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humans. Gastroenterology. 2012;143:730-740 pubmed publisher
    ..Tumors that arise from these polyps frequently contain activating mutations in BRAF or KRAS, but little is known about the role of EGFR activation in their development...
  75. Rex D, Ahnen D, Baron J, Batts K, Burke C, Burt R, et al. Serrated lesions of the colorectum: review and recommendations from an expert panel. Am J Gastroenterol. 2012;107:1315-29; quiz 1314, 1330 pubmed publisher
    ..pathologically according to the World Health Organization criteria as hyperplastic polyp, sessile serrated adenoma/polyp (SSA/P) with or without cytological dysplasia, or traditional serrated adenoma (TSA)...
  76. Murthy M, Azizan E, Brown M, O Shaughnessy K. Characterization of a novel somatic KCNJ5 mutation delI157 in an aldosterone-producing adenoma. J Hypertens. 2012;30:1827-33 pubmed publisher
    ..Here, we report the functional properties of KCNJ5 channels carrying this novel delI157 mutation...
  77. Paggi S, Rondonotti E, Amato A, Terruzzi V, Imperiali G, Mandelli G, et al. Resect and discard strategy in clinical practice: a prospective cohort study. Endoscopy. 2012;44:899-904 pubmed publisher
    ..The aim of the present study was to assess the feasibility and safety of this approach in routine clinical practice...
  78. Kim H, Koo B, Cho J, Kim Y, Seong J, Chang H, et al. Notch1 counteracts WNT/?-catenin signaling through chromatin modification in colorectal cancer. J Clin Invest. 2012;122:3248-59 pubmed publisher
    ..Activation of Notch1 converted high-grade adenoma into low-grade adenoma in an Apcmin mouse colon cancer model and suppressed the expression of WNT target genes in ..
  79. Patel N, Islam R, Wu Q, Gurudu S, Ramirez F, Crowell M, et al. Measurement of polypectomy rate by using administrative claims data with validation against the adenoma detection rate. Gastrointest Endosc. 2013;77:390-4 pubmed publisher
    The adenoma detection rate (ADR) is a main quality indicator in colonoscopy but has many challenges for calculating...
  80. Alvarez C, Andreu M, Castells A, Quintero E, Bujanda L, Cubiella J, et al. Relationship of colonoscopy-detected serrated polyps with synchronous advanced neoplasia in average-risk individuals. Gastrointest Endosc. 2013;78:333-341.e1 pubmed publisher
    ..Serrated cancers account for 10% to 20% of all colorectal cancers (CRC) and more than 30% of interval cancers. The presence of proximal serrated polyps and large (?10 mm) serrated polyps (LSP) has been correlated with colorectal neoplasia...
  81. Sillars Hardebol A, Carvalho B, Tijssen M, Belien J, de Wit M, Delis van Diemen P, et al. TPX2 and AURKA promote 20q amplicon-driven colorectal adenoma to carcinoma progression. Gut. 2012;61:1568-75 pubmed
    Progression of a colorectal adenoma to invasive cancer occurs in a minority of adenomas and is the most crucial step in colorectal cancer pathogenesis...
  82. Tichomirowa M, Lee M, Barlier A, Daly A, Marinoni I, Jaffrain Rea M, et al. Cyclin-dependent kinase inhibitor 1B (CDKN1B) gene variants in AIP mutation-negative familial isolated pituitary adenoma kindreds. Endocr Relat Cancer. 2012;19:233-41 pubmed publisher
    Familial isolated pituitary adenoma (FIPA) occurs in families and is unrelated to multiple endocrine neoplasia type 1 and Carney complex. Mutations in AIP account only for 15-25% of FIPA families...
  83. Chen J, Lin Y, Zhang R, Huang Z, Pan X. Contribution of NAD(P)H quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and risk of colorectal adenoma and colorectal cancer in Caucasians: a meta-analysis. Arch Med Res. 2012;43:58-66 pubmed publisher
    ..of polymorphism of NAD(P)H quinone oxidoreductase 1 (NQO1 Pro187Ser, rs1800566) on the risks of colorectal adenoma and cancer have been widely studied and results remain controversial...
  84. Powell A, Wang Y, Li Y, Poulin E, Means A, Washington M, et al. The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor. Cell. 2012;149:146-58 pubmed publisher
  85. Edwards T, Shrubsole M, Cai Q, Li G, Dai Q, Rex D, et al. A study of prostaglandin pathway genes and interactions with current nonsteroidal anti-inflammatory drug use in colorectal adenoma. Cancer Prev Res (Phila). 2012;5:855-63 pubmed publisher
    ..In this study, we used data from the Tennessee Colorectal Polyp Study and the Tennessee-Indiana Adenoma Recurrence Study to evaluate selected genes from the prostaglandin (PG) metabolism and signaling pathways for ..
  86. Blanks R, Moss S. The calculation of targets for the cancer and adenoma detection rates for the NHS bowel screening programme. J Med Screen. 2012;19:72-6 pubmed publisher
    ..This paper describes the calculation of targets for the purpose of monitoring screening performance in the programme...
  87. Kim J, Jang S, Hwang J, Ha S, Choi W, Park J, et al. [A ten-year follow-up of a case with gastric adenoma accompanied with gastritis cystica profunda treated by endoscopic submucosal dissection]. Korean J Gastroenterol. 2012;59:366-71 pubmed
    ..Herein, we report a case of gastric adenoma associated with GCP in an unoperated patient...
  88. Fu B, Yachida S, Morgan R, Zhong Y, Montgomery E, Iacobuzio Donahue C. Clinicopathologic and genetic characterization of traditional serrated adenomas of the colon. Am J Clin Pathol. 2012;138:356-66 pubmed publisher
    ..However, conventional epithelial dysplasia and abnormal p53 labeling in a TSA are seen more often in the setting of BRAF mutation...
  89. Pohl H, Srivastava A, Bensen S, Anderson P, Rothstein R, Gordon S, et al. Incomplete polyp resection during colonoscopy-results of the complete adenoma resection (CARE) study. Gastroenterology. 2013;144:74-80.e1 pubmed publisher
    Although the adenoma detection rate is used as a measure of colonoscopy quality, there are limited data on the quality of endoscopic resection of detected adenomas...
  90. Koutourousiou M, Gardner P, Fernandez Miranda J, Paluzzi A, Wang E, Snyderman C. Endoscopic endonasal surgery for giant pituitary adenomas: advantages and limitations. J Neurosurg. 2013;118:621-31 pubmed publisher
    ..Endoscopic endonasal surgery (EES) has recently been introduced as a treatment option for these tumors. The authors present the results of EES for giant adenomas and analyze the advantages and limitations of this technique...
  91. Nik A, Reyahi A, Ponten F, Carlsson P. Foxf2 in intestinal fibroblasts reduces numbers of Lgr5(+) stem cells and adenoma formation by inhibiting Wnt signaling. Gastroenterology. 2013;144:1001-11 pubmed publisher
    ..We investigated how in intestinal fibroblasts the forkhead transcription factor Foxf2 controls Wnt signaling to affect numbers of stem cells and formation and growth of adenomas in mice...