gestational trophoblastic disease


Summary: A group of diseases arising from pregnancy that are commonly associated with hyperplasia of trophoblasts (TROPHOBLAST) and markedly elevated human CHORIONIC GONADOTROPIN. They include HYDATIDIFORM MOLE, invasive mole (HYDATIDIFORM MOLE, INVASIVE), placental-site trophoblastic tumor (TROPHOBLASTIC TUMOR, PLACENTAL SITE), and CHORIOCARCINOMA. These neoplasms have varying propensities for invasion and spread.

Top Publications

  1. Hromadnikova I, Kotlabova K, Krofta L, Hron F. Follow-up of gestational trophoblastic disease/neoplasia via quantification of circulating nucleic acids of placental origin using C19MC microRNAs, hypermethylated RASSF1A, and SRY sequences. Tumour Biol. 2017;39:1010428317697548 pubmed publisher
    ..miR-520a-5p, miR-520h, miR-525, and miR-526a) for the diagnosis and consecutive follow-up of gestational trophoblastic disease/neoplasia...
  2. Dantas P, Maestá I, Filho J, Junior J, Elias K, Howoritz N, et al. Does hormonal contraception during molar pregnancy follow-up influence the risk and clinical aggressiveness of gestational trophoblastic neoplasia after controlling for risk factors?. Gynecol Oncol. 2017;147:364-370 pubmed publisher
    ..The use of HC during postmolar follow-up or GTN treatment does not seem to increase the risk of GTN or its severity and does not postpone the normalization of hCG levels. ..
  3. Berkowitz R, Goldstein D. Current advances in the management of gestational trophoblastic disease. Gynecol Oncol. 2013;128:3-5 pubmed publisher
  4. Ngan H, Kohorn E, Cole L, Kurman R, Kim S, Lurain J, et al. Trophoblastic disease. Int J Gynaecol Obstet. 2012;119 Suppl 2:S130-6 pubmed publisher
  5. Piura E, Piura B. Brain metastases from gestational trophoblastic neoplasia: review of pertinent literature. Eur J Gynaecol Oncol. 2014;35:359-67 pubmed
    ..Nonetheless, brain metastasis from GTN is a grave disease with a median survival time from diagnosis of brain metastasis of about 12 months. ..
  6. Eysbouts Y, Massuger L, Inthout J, Lok C, Sweep F, Ottevanger P. The added value of hysterectomy in the management of gestational trophoblastic neoplasia. Gynecol Oncol. 2017;145:536-542 pubmed publisher
    ..For patients with widespread metastatic disease, the benefit of hysterectomy lies in the removal of chemotherapy-resistant tumor bulk with subsequent effect on survival. ..
  7. Kong Y, Yang J, Jiang F, Zhao J, Ren T, Li J, et al. Clinical characteristics and prognosis of ultra high-risk gestational trophoblastic neoplasia patients: A retrospective cohort study. Gynecol Oncol. 2017;146:81-86 pubmed publisher
    ..Moreover, salvage surgery may improve the prognosis. Floxuridine-based multiagent chemotherapy is effective with manageable toxicity for ultra high-risk GTN patients. ..
  8. Essel K, Bruegl A, Gershenson D, Ramondetta L, Naumann R, Brown J. Salvage chemotherapy for gestational trophoblastic neoplasia: Utility or futility?. Gynecol Oncol. 2017;146:74-80 pubmed publisher
    ..Several salvage chemotherapy regimens demonstrate activity in high risk GTN. Multiple regimens may be required and cure is not universal. ..
  9. Asmar F, Braga Neto A, de Rezende Filho J, Villas Bôas J, Charry R, Maestá I. Uterine artery Doppler flow velocimetry parameters for predicting gestational trophoblastic neoplasia after complete hydatidiform mole, a prospective cohort study. Clinics (Sao Paulo). 2017;72:284-288 pubmed publisher
    ..Uterine Doppler flow velocimetry measurements, particularly pre- and post-molar evacuation pulsatility indices, can be useful for predicting postmolar gestational trophoblastic neoplasia. ..

More Information


  1. Laganà A, Vitale S, De Dominici R, Padula F, Rapisarda A, Biondi A, et al. Fertility outcome after laparoscopic salpingostomy or salpingectomy for tubal ectopic pregnancy A 12-years retrospective cohort study. Ann Ital Chir. 2016;87:461-465 pubmed
  2. Sefidbakht S, Hosseini F, Bijan B, Hamedi B, Azizi T. Qualitative and quantitative analysis of diffusion-weighted imaging of gestational trophoblastic disease: Can it predict progression of molar pregnancy to persistent form of disease?. Eur J Radiol. 2017;88:71-76 pubmed publisher
    To describe the diffusion-weighted imaging (DWI) appearance of gestational trophoblastic disease (GTD) and to determine its apparent diffusion coefficient (ADC) values...
  3. Parker V, Pacey A, Palmer J, Tidy J, Winter M, Hancock B. Classification systems in Gestational trophoblastic neoplasia - Sentiment or evidenced based?. Cancer Treat Rev. 2017;56:47-57 pubmed publisher
    ..This culminates in a critique of the current FIGO/WHO prognostic system and discussion surrounding clinical preference versus evidence based practice. ..
  4. . Current FIGO staging for cancer of the vagina, fallopian tube, ovary, and gestational trophoblastic neoplasia. Int J Gynaecol Obstet. 2009;105:3-4 pubmed
  5. Wang Z, Li X, Pan J, Chen J, Shi H, Zhang X, et al. Bleeding from gestational trophoblastic neoplasia: embolotherapy efficacy and tumour response to chemotherapy. Clin Radiol. 2017;72:992.e7-992.e11 pubmed publisher
    ..SAE can effectively control haemorrhage from GTN and these patients had good response to systemic chemotherapy following successful SAE. Uterine bleeding may recur due to uterine AVMs, even following complete embolisation and CR of GTN. ..