choriocarcinoma

Summary

Summary: A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).

Top Publications

  1. Han B, Xiang Y, Wang Y, Wang Z, Zhang H, Huang S. Dihydrofolate reductase transcript level is not suitable for methotrexate-resistance prediction in choriocarcinoma cell line. Int J Gynecol Cancer. 2010;20:1259-63 pubmed
    To assess whether dihydrofolate reductase (DHFR) expression is correlated with the concentration of methotrexate (MTX) exposure and the resistance index during the establishment of MTX-resistant human choriocarcinoma JeG-3 cell line.
  2. Rytting E, Audus K. Effects of low oxygen levels on the expression and function of transporter OCTN2 in BeWo cells. J Pharm Pharmacol. 2007;59:1095-102 pubmed
    ..The OCTN1 substrate ergothioneine reversed the effects of hypoxia on carnitine transport, but identical concentrations of N-acetylcysteine, another water-soluble intracellular antioxidant, did not have the same effect. ..
  3. Shyu M, Lin M, Shih J, Lee C, Huang J, Liao C, et al. Mucin 15 is expressed in human placenta and suppresses invasion of trophoblast-like cells in vitro. Hum Reprod. 2007;22:2723-32 pubmed
    ..The effects of MUC15 on trophoblast invasion in vitro were analyzed by matrigel invasion assay in human choriocarcinoma JAR and JEG-3 cells. MUC15 was expressed most highly in human placenta...
  4. Shih I. Trophoblastic vasculogenic mimicry in gestational choriocarcinoma. Mod Pathol. 2011;24:646-52 pubmed publisher
    ..These findings provide cogent evidence that choriocarcinoma represents one of a few human tumor types that utilizes vasculogenic mimicry by tumor cell in supporting ..
  5. Fujita D, Tanabe A, Sekijima T, Soen H, Narahara K, Yamashita Y, et al. Role of extracellular signal-regulated kinase and AKT cascades in regulating hypoxia-induced angiogenic factors produced by a trophoblast-derived cell line. J Endocrinol. 2010;206:131-40 pubmed publisher
    ..Our results suggest that both the phosphatidylinositol 3-kinase-AKT-MTOR-HIF-1alpha and ERK-HIF-1alpha signaling pathways are crucial for increasing VEGF and endoglin expression in response to hypoxia in BeWo cells. ..
  6. Li A, Siu M, Zhang H, Wong E, Chan K, Ngan H, et al. Hypermethylation of SOX2 gene in hydatidiform mole and choriocarcinoma. Reprod Sci. 2008;15:735-44 pubmed publisher
    ..The methylation status of SOX2 promoter region in 55 hydatidiform moles, 4 choriocarcinoma, 23 first trimester, and 15 term placentas was evaluated by methylation-specific polymerase chain reaction...
  7. Hoffner L, Surti U. The genetics of gestational trophoblastic disease: a rare complication of pregnancy. Cancer Genet. 2012;205:63-77 pubmed publisher
    Gestational choriocarcinoma is usually a rapidly spreading fatal disease, but it is curable if diagnosed early and treated...
  8. Balat O, Kutlar I, Ozkur A, Bakir K, Aksoy F, Ugur M. Primary pure ovarian choriocarcinoma mimicking ectopic pregnancy: a report of fulminant progression. Tumori. 2004;90:136-8 pubmed
    Nongestational choriocarcinoma of the ovary is a germ cell tumor with a worse prognosis than gestational choriocarcinoma...
  9. Ceckova M, Libra A, Pavek P, Nachtigal P, Brabec M, Fuchs R, et al. Expression and functional activity of breast cancer resistance protein (BCRP, ABCG2) transporter in the human choriocarcinoma cell line BeWo. Clin Exp Pharmacol Physiol. 2006;33:58-65 pubmed
    ..In the present study, we evaluated the localization and functional expression of BCRP in the human choriocarcinoma cell line BeWo, an in vitro model of the human trophoblast, and compared it with the expression of P-..

More Information

Publications80

  1. Zairi F, De Saint Denis T, Thines L, Bourgeois P, Lejeune J. Ruptured cerebral oncotic aneurysm from choriocarcinoma: report of two cases and review of the literature. Acta Neurochir (Wien). 2011;153:353-7 pubmed publisher
    The study design involved case reports and review of the literature. Oncotic aneurysm from choriocarcinoma is an extremely rare event that should be known by all neurosurgeons and suspected in women of childbearing age...
  2. Jingting C, Yangde Z, Yi Z, Huining L, Rong Y, Yu Z. Heparanase expression correlates with metastatic capability in human choriocarcinoma. Gynecol Oncol. 2007;107:22-9 pubmed
    In this report, we studied the role of Hpa in metastatic capability of human choriocarcinoma. At the same time, we investigated the effect of Hpa antisense oligodeoxynucleotide (ASODN) on inhibition of invasiveness of human ..
  3. Pang R, Leung C, Ye T, Liu W, Chiu P, Lam K, et al. MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells. Carcinogenesis. 2010;31:1037-44 pubmed publisher
    ..Our results provide evidence that miR-34a inhibits invasiveness through regulation of the Notch pathway and its downstream matrix degrading enzyme. ..
  4. Singh M, Kindelberger D, Nagymanyoki Z, Ng S, Quick C, Yamamoto H, et al. Vascular endothelial growth factors and their receptors and regulators in gestational trophoblastic diseases and normal placenta. J Reprod Med. 2012;57:197-203 pubmed
    ..levels of VEGF and VEGFR-2 were determined in supernatants and lysates of normal trophoblast, JEG-3 and JAR choriocarcinoma cells with electrochemiluminescence assays...
  5. Jiao Y, Liu W. Low-density lipoprotein receptor-related protein 1 is an essential receptor for trichosanthin in 2 choriocarcinoma cell lines. Biochem Biophys Res Commun. 2010;391:1579-84 pubmed publisher
    ..In this study, we demonstrated that 2 choriocarcinoma cell lines can significantly bind and internalize TCS...
  6. Schröpfer A, Kammerer U, Kapp M, Dietl J, Feix S, Anacker J. Expression pattern of matrix metalloproteinases in human gynecological cancer cell lines. BMC Cancer. 2010;10:553 pubmed publisher
    ..g. endometrial, cervical or ovarian carcinoma). In this study we investigated the expression pattern of the 23 MMPs, currently known in humans, in different gynecological cancer cell lines...
  7. Heazell A, Taylor N, Greenwood S, Baker P, Crocker I. Does altered oxygenation or reactive oxygen species alter cell turnover of BeWo choriocarcinoma cells?. Reprod Biomed Online. 2009;18:111-9 pubmed
    ..In addition, these data support a role for p53 in mediating altered trophoblast cell turnover in response to oxidative stress. ..
  8. Khurana R, Dibernardo C, Handa J. Improved systemic chemotherapy for metastatic testicular choriocarcinoma can result in excellent prognosis for life and vision. Arch Ophthalmol. 2008;126:1008-9 pubmed publisher
  9. Hsieh T, Hsu K, Kuo P, Huang S. Uterine choriocarcinoma accompanied by an extremely high human chorionic gonadotropin level and thyrotoxicosis. J Obstet Gynaecol Res. 2008;34:274-8 pubmed publisher
    The conventional treatments given to a 24-year-old woman with metastatic uterine choriocarcinoma and clinical and biochemical thyrotoxicosis did not appear to have any effect, probably due to an extremely high serum human chorionic ..
  10. Boronkai A, Brubel R, Racz B, Tamas A, Kiss P, Horvath G, et al. Effects of pituitary adenylate cyclase activating polypeptide on the survival and signal transduction pathways in human choriocarcinoma cells. Ann N Y Acad Sci. 2009;1163:353-7 pubmed publisher
    ..Our data show that the signaling mechanism of PACAP may be different in trophoblast cells to that observed in other cell lines. ..
  11. Oufkir T, Arseneault M, Sanderson J, Vaillancourt C. The 5-HT 2A serotonin receptor enhances cell viability, affects cell cycle progression and activates MEK-ERK1/2 and JAK2-STAT3 signalling pathways in human choriocarcinoma cell lines. Placenta. 2010;31:439-47 pubmed publisher
  12. Yu L, Chang K, Lu L, Zhao D, Han J, Zheng Y, et al. Lentivirus-mediated RNA interference targeting the H19 gene inhibits cell proliferation and apoptosis in human choriocarcinoma cell line JAR. BMC Cell Biol. 2013;14:26 pubmed publisher
    ..H19-specific small interfering RNA (siRNA) to specifically block the expression of H19 in the human choriocarcinoma cell line JAR...
  13. Kong B, Tian Y, Zhu W, Qin Y. A pure nongestational ovarian choriocarcinoma in a 10-year-old girl: case report and literature review. J Obstet Gynaecol Res. 2009;35:574-8 pubmed publisher
    Nongestational ovarian choriocarcinoma (NGCO) is a rare form of malignancy, which is difficult to diagnose. We present a case of a 10-year-old girl diagnosed with pure nongestational ovarian choriocarcinoma...
  14. Shih I, Kuo K. Power of the eternal youth: Nanog expression in the gestational choriocarcinoma. Am J Pathol. 2008;173:911-4 pubmed publisher
  15. Ramos A, Cantero M, Zhang P, Raychowdhury M, Green A, MacPhee D, et al. Morphological and electrical properties of human trophoblast choriocarcinoma, BeWo cells. Placenta. 2008;29:492-502 pubmed publisher
    ..In the present study, we investigated the morphological and electrical properties of BeWo cells, a human choriocarcinoma-derived trophoblast cell model, with several features of the human cytotrophoblast...
  16. Takahashi H, Matsuda H, Mizumoto Y, Furuya K. Intraplacental choriocarcinoma with fetomaternal hemorrhage: a case study and literature review. J Perinat Med. 2008;36:178-81 pubmed publisher
  17. Li F, Wang X, Men K, Xu D, Yan Y, Zhang J. Receptivity of human choriocarcinoma JEGIII cells and isolated trophoblast cells to hepatitis B virus infection and enhancement by tumor necrosis factor alpha. Jpn J Infect Dis. 2007;60:167-72 pubmed
    ..mechanism responsible for the passage of HBV from the maternal to the fetal circulation, we infected choriocarcinoma JEGIII cells and primary trophoblast cells with HBV...
  18. Shi H, Cao D, Wei L, Sun L, Guo A. Primary choriocarcinoma of the liver: a clinicopathological study of five cases in males. Virchows Arch. 2010;456:65-70 pubmed publisher
    ..Autopsy was performed for all five cases. The autopsy confirmed that the choriocarcinoma was confined to the liver in two surgically resected cases...
  19. Shimizu Y, Kusano M, Fujimori A, Kusano T, Taka J, Aoki T, et al. [A case of primary gastric choriocarcinoma treated by curative operation after neoadjuvant chemotherapy with S-1/CDDP]. Gan To Kagaku Ryoho. 2010;37:1135-8 pubmed
    We experienced a case of primary gastric choriocarcinoma(PGC)treated by curative operation after neoadjuvant chemotherapy with S-1/CDDP...
  20. Rauh A, Windischhofer W, Kovacevic A, DeVaney T, Huber E, Semlitsch M, et al. Endothelin (ET)-1 and ET-3 promote expression of c-fos and c-jun in human choriocarcinoma via ET(B) receptor-mediated G(i)- and G(q)-pathways and MAP kinase activation. Br J Pharmacol. 2008;154:13-24 pubmed publisher
    ..b>Choriocarcinoma cells display many of the biochemical and morphological characteristics of in utero invasive trophoblast ..
  21. Johnsen G, Weedon Fekjaer M, Tobin K, Staff A, Duttaroy A. Long-chain polyunsaturated fatty acids stimulate cellular fatty acid uptake in human placental choriocarcinoma (BeWo) cells. Placenta. 2009;30:1037-44 pubmed publisher
    ..These findings demonstrate that LCPUFA may function as an important regulator of general fatty acid uptake in trophoblast cells and may thus have impact on fetal growth and development...
  22. Wojtowicz A, Augustowska K, Gregoraszczuk E. The short- and long-term effects of two isomers of DDT and their metabolite DDE on hormone secretion and survival of human choriocarcinoma JEG-3 cells. Pharmacol Rep. 2007;59:224-32 pubmed
    ..These findings indicate that both isomers of DDT and their metabolite DDE are able to alter main placental hormone production and survival of JEG-3 cells in the concentration- and time-dependent manner...
  23. Harada M, Inoue T, Hamano K. Choriocarcinoma of the sigmoid colon: report of a case. Surg Today. 2012;42:93-6 pubmed publisher
    We report a rare case of primary choriocarcinoma of the colon. A 58-year-old woman underwent Hartmann's procedure to remove a sigmoid colon tumor, and pathological examination confirmed choriocarcinoma that had originated from the colon...
  24. Chittenden B, Ahamed E, Maheshwari A. Choriocarcinoma in a postmenopausal woman. Obstet Gynecol. 2009;114:462-5 pubmed publisher
    b>Choriocarcinoma typically occurs within 12 months of pregnancy but rarely may present many years after an antecedent pregnancy. This report describes choriocarcinoma in a postmenopausal woman.
  25. Tobin K, Johnsen G, Staff A, Duttaroy A. Long-chain polyunsaturated fatty acid transport across human placental choriocarcinoma (BeWo) cells. Placenta. 2009;30:41-7 pubmed publisher
    ..of LCPUFAs and a non-essential fatty acid (oleic acid, OA) in a transwell monolayer system of placental choriocarcinoma (BeWo) cells...
  26. Pongcharoen S, Supalap K. Interleukin-17 increased progesterone secretion by JEG-3 human choriocarcinoma cells. Am J Reprod Immunol. 2009;61:261-4 pubmed publisher
    JEG-3 choriocarcinoma cell line has previously been reported to express a receptor for interleukin (IL)-17...
  27. Naniwadekar M, Desai S, Kshirsagar N, Angarkar N, Dombale V, Jagtap S. Pure choriocarcinoma of ovary diagnosed by fine needle aspiration cytology. Indian J Pathol Microbiol. 2009;52:417-20 pubmed publisher
    Pure ovarian choriocarcinoma is extremely rare and can develop as a germ cell tumor or as a metastasis from uterine or tubal gestational choriocarcinoma or rarely from an ovarian pregnancy...
  28. Ma Y, Xiang Y, Wan X, Chen Y, Feng F, Lei C, et al. The prognostic analysis of 123 postpartum choriocarcinoma cases. Int J Gynecol Cancer. 2008;18:1097-101 pubmed
    A retrospective analysis of 123 postpartum choriocarcinoma cases treated at the Peking Union Medical College Hospital between December 1985 and December 2006 was performed...
  29. Harish Kumar G, Chandra Mohan K, Jagannadha Rao A, Nagini S. Nimbolide a limonoid from Azadirachta indica inhibits proliferation and induces apoptosis of human choriocarcinoma (BeWo) cells. Invest New Drugs. 2009;27:246-52 pubmed publisher
    ..effects of nimbolide, a limonoid present in leaves and flowers of the neem tree (Azadirachta indica) on human choriocarcinoma (BeWo) cells...
  30. Hoshiyama F, Hosokawa Y, Kumamoto H, Hayashi Y, Fujimoto K, Hirao Y. [Choriocarcinoma presenting as a spontaneous rupture of an adrenal metastasis: a case report]. Hinyokika Kiyo. 2008;54:281-4 pubmed
    ..An examination during surgery showed a rupture of adrenal tumor. En bloc resection of adrenal gland, tumor, and the kidney was performed. Pathological finding revealed the adrenal tumor was choriocarcinoma.
  31. Pang R, Leung C, Lee C, Lam K, Ye T, Chiu P, et al. MicroRNA-34a is a tumor suppressor in choriocarcinoma via regulation of Delta-like1. BMC Cancer. 2013;13:25 pubmed publisher
    b>Choriocarcinoma is a gestational trophoblastic tumor which causes high mortality if left untreated. MicroRNAs (miRNAs) are small non protein-coding RNAs which inhibit target gene expression...
  32. Hsieh Y, Chou M, Chen H, Tseng J. IMP1 promotes choriocarcinoma cell migration and invasion through the novel effectors RSK2 and PPME1. Gynecol Oncol. 2013;131:182-90 pubmed publisher
    ..Expression of IMP1 is limited to a few adult human tissues. However, it commonly expresses in a variety of cancers. Our objective was to study the regulatory mechanism of IMP1 on the cellular functions of choriocarcinoma (CC) JAR cells.
  33. Chen Y, Lv W, Chen H, Ye F, Xie X. Methotrexate induces apoptosis of human choriocarcinoma cell line JAR via a mitochondrial pathway. Eur J Obstet Gynecol Reprod Biol. 2009;143:107-11 pubmed publisher
    To investigate methotrexate (MTX)-induced apoptosis and the involved pathways in human choriocarcinoma cells.
  34. Huang C, Chen C, Hsieh C, Cheng W. Intracerebral hemorrhage as initial presentation of gestational choriocarcinoma: a case report and literature review. Int J Gynecol Cancer. 2007;17:1166-71 pubmed
    b>Choriocarcinoma is the most malignant tumor of gestational trophoblastic neoplasia. It grows rapidly and metastasizes to the lung, liver, and, less frequently, to the brain...
  35. Naito Y, Akeda K, Kasai Y, Matsumine A, Tabata T, Nagao K, et al. Lumbar metastasis of choriocarcinoma. Spine (Phila Pa 1976). 2009;34:E538-43 pubmed publisher
    A case of lumbar metastasis of a choriocarcinoma is presented.
  36. Tatokoro M, Kawakami S, Sakura M, Kobayashi T, Kihara K, Akamatsu H. Successful management of life-threatening choriocarcinoma syndrome with rupture of pulmonary metastatic foci causing hemorrhagic shock. Int J Urol. 2008;15:263-4 pubmed publisher
    ..Pathologic examination of the specimen revealed choriocarcinoma and yolk sac tumor. Through multimodal treatments he achieved complete remission...
  37. Honkisz E, Zieba Przybylska D, Wojtowicz A. The effect of triclosan on hormone secretion and viability of human choriocarcinoma JEG-3 cells. Reprod Toxicol. 2012;34:385-92 pubmed publisher
    ..Anti proliferative and pro-apoptotic effects were also observed. Overall, this study demonstrates that triclosan may indirectly disrupt steroidogenesis which may, in turn, affect placental development and consequently fetal growth...
  38. Bilban M, Tauber S, Haslinger P, Pollheimer J, Saleh L, Pehamberger H, et al. Trophoblast invasion: assessment of cellular models using gene expression signatures. Placenta. 2010;31:989-96 pubmed publisher
    ..expressed genes revealed that EVTs most closely resemble CTBs with considerable differences to the group of choriocarcinoma cells (JEG-3, BeWo, ACH-3P) and the group of SV40 Large T Antigen-selected cell types (SGHPL-5, HTR-8/SVneo)...
  39. Araujo J, Goncalves P, Martel F. Modulation of glucose uptake in a human choriocarcinoma cell line (BeWo) by dietary bioactive compounds and drugs of abuse. J Biochem. 2008;144:177-86 pubmed publisher
    ..and chronic (48 h) effect of these substances on the apical uptake of 3H-2-deoxy-D-glucose (3H-DG) by a human choriocarcinoma cell line (BeWo) was determined...
  40. Mak V, Lee L, Siu M, Wong O, Lu X, Ngan H, et al. Downregulation of ASPP1 in gestational trophoblastic disease: correlation with hypermethylation, apoptotic activity and clinical outcome. Mod Pathol. 2011;24:522-32 pubmed publisher
    ..and expression profiles of ASPP1 in different trophoblastic tissues and its in vitro functional effect on two choriocarcinoma cell lines, namely JEG-3 and JAR...
  41. Baumann M, Zamudio S, Illsley N. Hypoxic upregulation of glucose transporters in BeWo choriocarcinoma cells is mediated by hypoxia-inducible factor-1. Am J Physiol Cell Physiol. 2007;293:C477-85 pubmed
    ..of hypoxia on the regulation of trophoblast glucose transporter (GLUT) expression and activity in BeWo choriocarcinoma cells, a trophoblast cell model, and human placental villous tissue explants...
  42. Ronco A, Llaguno E, Epuñan M, Llanos M. Effect of cadmium on cortisol production and 11beta-hydroxysteroid dehydrogenase 2 expression by cultured human choriocarcinoma cells (JEG-3). Toxicol In Vitro. 2010;24:1532-7 pubmed publisher
    ..of acute low dose of cadmium on cortisol production and 11beta-HSD2 expression and activity by cultured human choriocarcinoma cells (JEG-3)...
  43. Brubel R, Boronkai A, Reglodi D, Racz B, Nemeth J, Kiss P, et al. Changes in the expression of pituitary adenylate cyclase-activating polypeptide in the human placenta during pregnancy and its effects on the survival of JAR choriocarcinoma cells. J Mol Neurosci. 2010;42:450-8 pubmed publisher
    ..The effects of PACAP on the survival of JAR human choriocarcinoma cells were investigated using flow cytometry and MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium ..
  44. Chao A, Tsai C, Wei P, Hsueh S, Chao A, Wang C, et al. Decreased expression of microRNA-199b increases protein levels of SET (protein phosphatase 2A inhibitor) in human choriocarcinoma. Cancer Lett. 2010;291:99-107 pubmed publisher
    We compared microRNA profiles between choriocarcinoma and non-cancerous trophoblasts, and revealed that miR-199b was underexpressed in choriocarcinoma...
  45. Pai M, Mathai A, Kumar S, Prabhu S. Coexistent gastric primary choriocarcinoma and adenocarcinoma. Indian J Pathol Microbiol. 2009;52:537-9 pubmed publisher
    ..We herein describe a case of primary gastric choriocarcinoma with liver metastasis in a 69-year-old male...
  46. Siu M, Wong E, Chan H, Ngan H, Chan K, Cheung A. Overexpression of NANOG in gestational trophoblastic diseases: effect on apoptosis, cell invasion, and clinical outcome. Am J Pathol. 2008;173:1165-72 pubmed publisher
    Gestational trophoblastic disease includes choriocarcinoma, a frankly malignant tumor, and hydatidiform mole (HM), which often leads to the development of persistent gestational trophoblastic neoplasia and requires chemotherapy...
  47. Vijay R, Kaduthodil M, Bottomley J, Abdi S. Metastatic gestational trophoblastic tumour presenting as spontaneous subcapsular renal haematoma. Br J Radiol. 2008;81:e234-7 pubmed publisher
    We describe a rare case of metastatic choriocarcinoma, which presented with acute left loin pain due to a subcapsular haematoma secondary to a bleeding renal metastasis. The renal metastasis was embolised to prevent further bleeding...
  48. Chang W, Hung Y, Shen H, Kao C. Choriocarcinoma with pulmonary metastasis: report of a case of successful treatment with serial FDG-PET follow-up. J Reprod Med. 2007;52:450-2 pubmed
    This is the first report of successful treatment of a case of choriocarcinoma with pulmonary metastasis using serial 2-(18F)-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) before, during and after treatment.
  49. Wu X, Iguchi T, Itoh N, Okamoto K, Takagi T, Tanaka K, et al. Ascorbic acid transported by sodium-dependent vitamin C transporter 2 stimulates steroidogenesis in human choriocarcinoma cells. Endocrinology. 2008;149:73-83 pubmed
    ..steroidogenesis, we tested the effects of AA treatment and SVCT2 knockdown on steroidogenesis in human choriocarcinoma cell lines...
  50. Kairi Vassilatou E, Papakonstantinou K, Grapsa D, Kondi Paphiti A, Hasiakos D. Primary gestational choriocarcinoma of the uterine cervix. Report of a case and review of the literature. Int J Gynecol Cancer. 2007;17:921-5 pubmed
    Gestational choriocarcinoma usually arises in the uterine cavity and is associated with coincident or antecedent pregnancy. Extrauterine choriocarcinomas are very rare entities, and most of these are located in the uterine cervix...
  51. Collett G, Linton E, Redman C, Sargent I. Downregulation of caveolin-1 enhances fusion of human BeWo choriocarcinoma cells. PLoS ONE. 2010;5:e10529 pubmed publisher
    ..used RNA interference to determine whether caveolin-1 plays a role in differentiation and fusion in the BeWo choriocarcinoma cell line, a model of villous cytotrophoblast fusion...
  52. Go J. Pure choriocarcinoma of testis with tumor-infiltrating lymphocytes and granulomas. Yonsei Med J. 2006;47:887-91 pubmed
    Pure choriocarcinoma is very rare in the testes, and host immune responses including tumor infiltrating lymphocytes are unusual in choriocarcinoma...
  53. Klempan T, Hudon Thibeault A, Oufkir T, Vaillancourt C, Sanderson J. Stimulation of serotonergic 5-HT2A receptor signaling increases placental aromatase (CYP19) activity and expression in BeWo and JEG-3 human choriocarcinoma cells. Placenta. 2011;32:651-656 pubmed publisher
    ..BeWo and JEG-3 choriocarcinoma cells were used as models of the human placental trophoblast to evaluate the effects of serotonin and ..
  54. Goldman S, Lovett D, Shalev E. Mechanisms of matrix metalloproteinase-2 (mmp-2) transcriptional repression by progesterone in jar choriocarcinoma cells. Reprod Biol Endocrinol. 2009;7:41 pubmed publisher
    ..This study aimed to explore the mechanism by which progesterone inhibits MMP-2 expression...
  55. Flores Martín J, Rena V, Marquez S, Panzetta Dutari G, Genti Raimondi S. StarD7 knockdown modulates ABCG2 expression, cell migration, proliferation, and differentiation of human choriocarcinoma JEG-3 cells. PLoS ONE. 2012;7:e44152 pubmed publisher
    ..Our data from an explorative microarray assay performed with mRNAs from StarD7 siRNA-transfected JEG-3 cells indicated that ABCG2 (ATP-binding cassette sub-family G member 2) was one of the most abundantly downregulated mRNAs...
  56. Wong N, Novakovic B, Weinrich B, Dewi C, Andronikos R, Sibson M, et al. Methylation of the adenomatous polyposis coli (APC) gene in human placenta and hypermethylation in choriocarcinoma cells. Cancer Lett. 2008;268:56-62 pubmed publisher
    ..We have examined the methylation of APC gene promoters in human placenta and choriocarcinoma cells...
  57. Al Nasiry S, Geusens N, Hanssens M, Luyten C, Pijnenborg R. The use of Alamar Blue assay for quantitative analysis of viability, migration and invasion of choriocarcinoma cells. Hum Reprod. 2007;22:1304-9 pubmed
    ..In this study, the vital dye AB (AB) was used to quantify cell number and viability of BeWo and JEG-3 choriocarcinoma cells, as well as their migration and invasion through fibronectin-coated filters.
  58. Maymó J, Pérez Pérez A, Sanchez Margalet V, Dueñas J, Calvo J, Varone C. Up-regulation of placental leptin by human chorionic gonadotropin. Endocrinology. 2009;150:304-13 pubmed publisher
    ..In the present work, we have found that recombinant human chorionic gonadotropin (hCG) added to BeWo choriocarcinoma cell line showed a stimulatory effect on endogenous leptin expression, when analyzed by Western blot...
  59. Chen Y, Qian H, Wang H, Zhang X, Fu M, Liang X, et al. Ad-PUMA sensitizes drug-resistant choriocarcinoma cells to chemotherapeutic agents. Gynecol Oncol. 2007;107:505-12 pubmed
    To investigate whether exogenous PUMA expression suppresses the growth of drug-resistant choriocarcinoma cells and sensitizes them to chemotherapeutic agents.
  60. Niimi K, Yamamoto E, Fujiwara S, Shinjo K, Kotani T, Umezu T, et al. High expression of N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma. Br J Cancer. 2012;107:1969-77 pubmed publisher
    ..the asparagine-linked sugar chains on hCG contain abnormal biantennary structures in invasive mole and choriocarcinoma, but not normal pregnancy or hydatidiform mole...
  61. Lurain J. Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol. 2010;203:531-9 pubmed publisher
    ..includes hydatidiform mole (complete and partial) and gestational trophoblastic neoplasia (invasive mole, choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor)...
  62. Kawamura N, Kawamura K, Manabe M, Tanaka T. Inhibition of brain-derived neurotrophic factor/tyrosine kinase B signaling suppresses choriocarcinoma cell growth. Endocrinology. 2010;151:3006-14 pubmed publisher
    ..Here, we found the expression of BDNF and neurtropin-4/5 together with TrkB in human trophoblastic choriocarcinoma cells...
  63. Fu J, Lv X, Lin H, Wu L, Wang R, Zhou Z, et al. Ubiquitin ligase cullin 7 induces epithelial-mesenchymal transition in human choriocarcinoma cells. J Biol Chem. 2010;285:10870-9 pubmed publisher
    ..However, CUL7 levels in term trophoblast cells or JEG-3 cells, which are derived from human choriocarcinoma but exhibit weak invasion capacity, were low or undetectable...
  64. Jingting C, Huining L, Yi Z. Preparation and characterization of magnetic nanoparticles containing Fe(3)O(4)-dextran-anti-?-human chorionic gonadotropin, a new generation choriocarcinoma-specific gene vector. Int J Nanomedicine. 2011;6:285-94 pubmed publisher
    ..To evaluate the feasibility of using magnetic iron oxide (Fe(3)O(4))-dextran-anti-?-human chorionic gonadotropin (HCG) nanoparticles as a gene vector for cellular transfections...
  65. Morales Prieto D, Schleussner E, Markert U. Reduction in miR-141 is induced by leukemia inhibitory factor and inhibits proliferation in choriocarcinoma cell line JEG-3. Am J Reprod Immunol. 2011;66 Suppl 1:57-62 pubmed publisher
    ..The influence of LIF on miRNA expression in trophoblastic cells has not yet been analyzed and was focus of this investigation...
  66. Mao T, Kurman R, Huang C, Lin M, Shih I. Immunohistochemistry of choriocarcinoma: an aid in differential diagnosis and in elucidating pathogenesis. Am J Surg Pathol. 2007;31:1726-32 pubmed
    b>Choriocarcinoma is traditionally described as being composed of cytotrophoblast and syncytiotrophoblast...
  67. Wang H, Lee E, Zhou L, Leung P, Ross D, Unadkat J, et al. Progesterone receptor (PR) isoforms PRA and PRB differentially regulate expression of the breast cancer resistance protein in human placental choriocarcinoma BeWo cells. Mol Pharmacol. 2008;73:845-54 pubmed
    ..In this study, we investigated the molecular mechanism by which BCRP expression in human placental choriocarcinoma BeWo cells is regulated by progesterone...
  68. Lal A, Singhal M, Kumar S, Bag S, Singh S, Khandelwal N. Bilateral renal and jejunal metastasis of choriocarcinoma presenting as spontaneous renal hemorrhage. Cancer Imaging. 2009;9:56-8 pubmed publisher
    ..We report a case of SRH and episodic gross hematuria in a patient with metastatic choriocarcinoma involving both kidneys for which successful angioembolization was carried out for control of hemorrhage...
  69. Suman P, Poehlmann T, Prakash G, Markert U, Gupta S. Interleukin-11 increases invasiveness of JEG-3 choriocarcinoma cells by modulating STAT3 expression. J Reprod Immunol. 2009;82:1-11 pubmed publisher
    ..the IL-6 family, was investigated for its role in regulating invasion, migration and proliferation of JEG-3 choriocarcinoma cells...
  70. Fujiwara H, Nishioka Y, Matsumoto H, Suginami K, Horie A, Tani H, et al. Eph-ephrin A system regulates human choriocarcinoma-derived JEG-3 cell invasion. Int J Gynecol Cancer. 2013;23:576-82 pubmed publisher
    ..of the Eph-ephrin system in the invasion of malignant gestational trophoblastic diseases using a human choriocarcinoma-derived cell line, JEG-3...
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    This article reports a uterine gestational choriocarcinoma arising in a 57-year-old woman with a long latent period of 22 years from the last known pregnancy...