teratocarcinoma

Summary

Summary: A malignant neoplasm consisting of elements of teratoma with those of embryonal carcinoma or choriocarcinoma, or both. It occurs most often in the testis. (Dorland, 27th ed)

Top Publications

  1. Yoshida K, Morita T. Control of radiosensitivity of F9 mouse teratocarcinoma cells by regulation of histone H2AX gene expression using a tetracycline turn-off system. Cancer Res. 2004;64:4131-6 pubmed
    ..We constructed a tetracycline (tet)-directed turn-off vector and integrated it into F9 mouse teratocarcinoma cells by homologous recombination...
  2. Megiorni F, Mora B, Indovina P, Mazzilli M. Expression of neuronal markers during NTera2/cloneD1 differentiation by cell aggregation method. Neurosci Lett. 2005;373:105-9 pubmed
    Human teratocarcinoma NTera2/cloneD1 (NT2) cells are able to generate postmitotic neurons in response to retinoic acid (RA) and for this reason these cells provide an important tool to study human neurogenesis in vitro...
  3. Giovarelli M, Bucci G, Pasero M, Gherzi R, Briata P. KSRP silencing favors neural differentiation of P19 teratocarcinoma cells. Biochim Biophys Acta. 2013;1829:469-79 pubmed publisher
    ..Our data suggests that KSRP function is required to maintain P19 cells in a multipotent undifferentiated state and that its inactivation can orient cells towards neural differentiation...
  4. Lopatina N, Poole J, Saldanha S, Hansen N, Key J, Pita M, et al. Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells. Biochem Biophys Res Commun. 2003;306:650-9 pubmed
    ..Undifferentiated embryonic human teratocarcinoma (HT) cells were found to express high levels of hTERT, the catalytic subunit of telomerase, and the hTERT ..
  5. Mosselman S, Claesson Welsh L, Kamphuis J, van Zoelen E. Developmentally regulated expression of two novel platelet-derived growth factor alpha-receptor transcripts in human teratocarcinoma cells. Cancer Res. 1994;54:220-5 pubmed
    ..5 kilobases and 5.0 kilobases are expressed in the human teratocarcinoma cell line Tera-2 only while the cells are in an undifferentiated state...
  6. Sodja C, Fang H, Dasgupta T, Ribecco M, Walker P, Sikorska M. Identification of functional dopamine receptors in human teratocarcinoma NT2 cells. Brain Res Mol Brain Res. 2002;99:83-91 pubmed
    ..to brain disorders, we have characterised the expression and functionality of dopamine receptors in human teratocarcinoma NT2 cells...
  7. Hohjoh H, Fukushima T. Marked change in microRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonal carcinoma P19 cells. Biochem Biophys Res Commun. 2007;362:360-7 pubmed
    ..Here we report on the expression profile analysis of miRNAs in human teratocarcinoma NTere2D1, mouse embryonic carcinoma P19, mouse neuroblastoma Neuro2a and rat pheochromocytoma PC12D cells, ..
  8. Nozaki T, Masutani M, Watanabe M, Ochiya T, Hasegawa F, Nakagama H, et al. Syncytiotrophoblastic giant cells in teratocarcinoma-like tumors derived from Parp-disrupted mouse embryonic stem cells. Proc Natl Acad Sci U S A. 1999;96:13345-50 pubmed
    ..These ES cells, irrespective of the Parp genotype, produced tumors phenotypically similar to teratocarcinoma when injected s.c. into nude mice...
  9. Kim A, Lee C, Schlessinger D. Bex3 associates with replicating mitochondria and is involved in possible growth control of F9 teratocarcinoma cells. Gene. 2004;343:79-89 pubmed
    ..Visualized by deconvolution microscopy as a GFP-fusion protein in F9 teratocarcinoma cells, Bex3 localized, along with concentrations of actin, at perinuclear mitochondria that were undergoing ..

More Information

Publications67

  1. Sandhu J, Sikorska M, Walker P. Characterization of astrocytes derived from human NTera-2/D1 embryonal carcinoma cells. J Neurosci Res. 2002;68:604-14 pubmed
    ..We report here that NTera-2 (NT2/D1, a cell line derived from a human teratocarcinoma and known to differentiate into neurons) can also be differentiated by a 4-week treatment with retinoic acid ..
  2. Xu J, Sylvester R, Tighe A, Chen S, Gudas L. Transcriptional activation of the suppressor of cytokine signaling-3 (SOCS-3) gene via STAT3 is increased in F9 REX1 (ZFP-42) knockout teratocarcinoma stem cells relative to wild-type cells. J Mol Biol. 2008;377:28-46 pubmed publisher
    ..repressed by retinoic acid (RA), encodes a zinc finger transcription factor expressed at high levels in F9 teratocarcinoma stem cells, embryonic stem cells, and other stem cells...
  3. Görtz P, Fleischer W, Rosenbaum C, Otto F, Siebler M. Neuronal network properties of human teratocarcinoma cell line-derived neurons. Brain Res. 2004;1018:18-25 pubmed
    ..We conclude that embryonic cortical neurons and hNT neurons have different network properties. This should be carefully considered before hNT neurons are used in therapeutic approaches, e g., central nervous system (CNS) grafting...
  4. Kwon Y, Ko J, Byung Gyu K, Kim M, Kim B. Analysis of plausible downstream target genes of Hoxc8 in F9 teratocarcinoma cells. Putative downstream target genes of Hoxc8. Mol Biol Rep. 2003;30:141-8 pubmed
    ..Hoxc8 downstream target genes, a stable cell line overexpressing Hoxc8 was established using F9 murine teratocarcinoma cells, proteom samples were analyzed by 2-DE, and compared with controls...
  5. Bieda K, Hoffmann A, Boller K. Phenotypic heterogeneity of human endogenous retrovirus particles produced by teratocarcinoma cell lines. J Gen Virol. 2001;82:591-6 pubmed
    ..5% of the human genome. The only HERV known to express virus particles is human teratocarcinoma-derived virus (HTDV), which is now termed HTDV/HERV-K...
  6. Paquet Durand F, Tan S, Bicker G. Turning teratocarcinoma cells into neurons: rapid differentiation of NT-2 cells in floating spheres. Brain Res Dev Brain Res. 2003;142:161-7 pubmed
    Cells from the human teratocarcinoma line NTera-2 can be induced to terminally differentiate into postmitotic neurons when treated with retinoic acid...
  7. Liu T, Liu X, Wang H, Moon R, Malbon C. Activation of rat frizzled-1 promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via pathways that require Galpha(q) and Galpha(o) function. J Biol Chem. 1999;274:33539-44 pubmed
    ..Medium conditioned by mouse F9 teratocarcinoma stem cells stably transfected to express either Xenopus Wnt-5a or Wnt-8 was used to test primitive endoderm ..
  8. Hovatta O, Jaconi M, Tohonen V, Bena F, Gimelli S, Bosman A, et al. A teratocarcinoma-like human embryonic stem cell (hESC) line and four hESC lines reveal potentially oncogenic genomic changes. PLoS ONE. 2010;5:e10263 pubmed publisher
    ..from the only single blastomere that survived cryopreservation of an embryo, and it more closely resembles teratocarcinoma lines than other hESC lines with respect to its abnormal karyotype and its formation of invasive tumors when ..
  9. Lee Y, Lee H, Lee Y, Chung H, Kim S, Lee S, et al. Involvement of glucocorticoid receptor in the induction of differentiation by ginsenosides in F9 teratocarcinoma cells. J Steroid Biochem Mol Biol. 1998;67:105-11 pubmed
    We have previously reported that ginsenosides Rh1 and Rh2 induced the differentiation of F9 teratocarcinoma stem cells [Lee, Y. N., Lee, H. Y., Chung, H. Y., Kim, S. I., Lee, S. K., Park, B. C. and Kim, K. W...
  10. Faria T, LaRosa G, Wilen E, Liao J, Gudas L. Characterization of genes which exhibit reduced expression during the retinoic acid-induced differentiation of F9 teratocarcinoma cells: involvement of cyclin D3 in RA-mediated growth arrest. Mol Cell Endocrinol. 1998;143:155-66 pubmed
    In the presence of retinoic acid (RA), F9 murine teratocarcinoma cells differentiate into cells resembling the extra-embryonic endoderm of the early mouse embryo...
  11. Liu C, Xu S, Ma Z, Zeng Y, Chen Z, Lu Y. Generation of pluripotent cancer-initiating cells from transformed bone marrow-derived cells. Cancer Lett. 2011;303:140-9 pubmed publisher
    ..These findings demonstrate that pluripotent cancer-initiating cells can originate from BMDCs. It provides an accessible in vitro model for copying the "embryonal rest" phenomenon from adult cells...
  12. Zhuang Y, Faria T, Chambon P, Gudas L. Identification and characterization of retinoic acid receptor beta2 target genes in F9 teratocarcinoma cells. Mol Cancer Res. 2003;1:619-30 pubmed
    ..analysis, we have identified and characterized genes that are differentially expressed in F9 RARbeta(2)(-/-) teratocarcinoma cells...
  13. Li H, Malbon C, Wang H. Gene profiling of Frizzled-1 and Frizzled-2 signaling: expression of G-protein-coupled receptor chimeras in mouse F9 teratocarcinoma embryonal cells. Mol Pharmacol. 2004;65:45-55 pubmed
    ..Genes activated in mouse totipotent F9 teratocarcinoma cells solely by activation of the Rfz1 chimera include Lefty1, STAM, JAB, Erk1, MyD118, Fcer Ig, and ..
  14. Gillespie R, Gudas L. Retinoic acid receptor isotype specificity in F9 teratocarcinoma stem cells results from the differential recruitment of coregulators to retinoic response elements. J Biol Chem. 2007;282:33421-34 pubmed
    ..acid receptor (RAR) alpha, beta(2), and gamma isotypes each regulate specific subsets of target genes in F9 teratocarcinoma stem cells...
  15. Longobardi E, Blasi F. Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation. J Biol Chem. 2003;278:39235-41 pubmed
    ..This effect has important functional consequences. F9 teratocarcinoma cells stably transfected with PREP-1 had an increased DNA binding activity to a PREP-PBX-responsive element...
  16. Krawetz R, Kelly G. Moesin signalling induces F9 teratocarcinoma cells to differentiate into primitive extraembryonic endoderm. Cell Signal. 2008;20:163-75 pubmed
    The mouse F9 teratocarcinoma cell line is a model that can be manipulated to imitate one of the earliest epithelial-mesenchymal transitions in mouse development...
  17. Solter D. From teratocarcinomas to embryonic stem cells and beyond: a history of embryonic stem cell research. Nat Rev Genet. 2006;7:319-27 pubmed publisher
    ..Here I briefly recapitulate this fascinating history...
  18. Gokhale P, Giesberts A, Andrews P. Brachyury is expressed by human teratocarcinoma cells in the absence of mesodermal differentiation. Cell Growth Differ. 2000;11:157-62 pubmed
    ..Thus, in human teratocarcinomas, Brachyury expression is not necessarily an indicator of commitment to mesodermal differentiation...
  19. Rennicke A, Voigt W, Mueller T, Fruehauf A, Schmoll H, Beyer C, et al. Resistance mechanisms following cisplatin and oxaliplatin treatment of the human teratocarcinoma cell line 2102EP. Anticancer Res. 2005;25:1147-55 pubmed
    ..Oxaliplatin and cisplatin are widely used in cancer chemotherapy, however, their clinical efficiency is often limited by the development of resistance...
  20. Dósa R, Burian K, Gonczol E. Human cytomegalovirus latency is associated with the state of differentiation of the host cells: an in vitro model in teratocarcinoma cells. Acta Microbiol Immunol Hung. 2005;52:397-406 pubmed
    ..This model system contributes to an understanding of HCMV latency and reactivation in vivo in the cells of the myeloid lineage...
  21. Sarraf S, Tejada R, Abawi M, Oberst M, Dennis T, Simon K, et al. The human ovarian teratocarcinoma cell line PA-1 demonstrates a single translocation: analysis with fluorescence in situ hybridization, spectral karyotyping, and bacterial artificial chromosome microarray. Cancer Genet Cytogenet. 2005;161:63-9 pubmed
    ..The ovarian teratocarcinoma cell line PA-1 demonstrates a single chromosomal aberration: a reciprocal t(15;20)(p11.2;q11.2)...
  22. Turner C, Granycome C, Hurst R, Pohler E, Juhola M, Juhola M, et al. Systematic segregation to mutant mitochondrial DNA and accompanying loss of mitochondrial DNA in human NT2 teratocarcinoma Cybrids. Genetics. 2005;170:1879-85 pubmed
    ..pathological mutation at nucleotide position 3243 of human mitochondrial DNA was introduced into human rho(0) teratocarcinoma (NT2) cells...
  23. Thompson J, Gudas L. Retinoic acid induces parietal endoderm but not primitive endoderm and visceral endoderm differentiation in F9 teratocarcinoma stem cells with a targeted deletion of the Rex-1 (Zfp-42) gene. Mol Cell Endocrinol. 2002;195:119-33 pubmed
    Cultured murine F9 teratocarcinoma stem cells resemble pluripotent stem cells of the inner cell mass of the mouse blastocyst and, depending upon their treatment, can be induced to differentiate along the primitive endoderm, the parietal ..
  24. Beyer T, Kolowos W, Dumitriu I, Voll R, Heyder P, Gaipl U, et al. Apoptosis of the teratocarcinoma cell line Tera-1 leads to the cleavage of HERV-K10gag proteins by caspases and/or granzyme B. Scand J Immunol. 2002;56:303-9 pubmed
    ..Therefore, immunogenicity of retroviral antigens in SLE patients may result from a similar mechanism as described for nuclear autoantigens...
  25. Hara K, Yasuhara T, Maki M, Matsukawa N, Masuda T, Yu S, et al. Neural progenitor NT2N cell lines from teratocarcinoma for transplantation therapy in stroke. Prog Neurobiol. 2008;85:318-34 pubmed publisher
    This review article discusses recent progress on the use of teratocarcinoma-derived Ntera2/D1 neuron-like cells (NT2N cells, also called hNT cells) as graft source for cell transplantation in stroke...
  26. Blum B, Benvenisty N. The tumorigenicity of human embryonic stem cells. Adv Cancer Res. 2008;100:133-58 pubmed publisher
    ..The problem of HESC-induced teratomas may also impede or prevent future HESC-based therapies. We thus conclude with a survey of approaches to evade HESC-induced tumor formation...
  27. Sharif T, Auger C, Bronner C, Alhosin M, Klein T, Etienne Selloum N, et al. Selective proapoptotic activity of polyphenols from red wine on teratocarcinoma cell, a model of cancer stem-like cell. Invest New Drugs. 2011;29:239-47 pubmed publisher
    ..Since teratocarcinoma cells are totipotent stem cells with a high degree of malignancy, we used them as a model of cancer stem ..
  28. Lutzker S, Mathew R, Taller D. A p53 dose-response relationship for sensitivity to DNA damage in isogenic teratocarcinoma cells. Oncogene. 2001;20:2982-6 pubmed
    ..b>Teratocarcinoma cells ex vivo in tissue culture are also relatively chemosensitive and undergo apoptotic death in response to ..
  29. Pera M, Herszfeld D. Differentiation of human pluripotent teratocarcinoma stem cells induced by bone morphogenetic protein-2. Reprod Fertil Dev. 1998;10:551-5 pubmed
    Pluripotent human teratocarcinoma stem cells cultured in vitro provide a resource for the study of early embryonic development in man, as well as a means for discovery of novel factors controlling cell differentiation and commitment...
  30. Boucquey M, De Plaen E, Locker M, Poliard A, Mouillet Richard S, Boon T, et al. Noxp20 and Noxp70, two new markers of early neuronal differentiation, detected in teratocarcinoma-derived neuroectodermic precursor cells. J Neurochem. 2006;99:657-69 pubmed
    The murine 1C11 cell line, derived from F9 pluripotent teratocarcinoma cells, exhibits features of a bipotential neuronal precursor as it converts into serotonergic or catecholaminergic neurons under appropriate induction...
  31. Zhang B, Ma X, Zhang W, Yeh C, Lin A, Luo J, et al. Polyunsaturated fatty acids mobilize intracellular Ca2+ in NT2 human teratocarcinoma cells by causing release of Ca2+ from mitochondria. Am J Physiol Cell Physiol. 2006;290:C1321-33 pubmed
    ..We have found that PUFA but not monounsaturated or saturated FA cause [Ca(2+)](i) mobilization in NT2 human teratocarcinoma cells...
  32. Blum B, Benvenisty N. The tumorigenicity of diploid and aneuploid human pluripotent stem cells. Cell Cycle. 2009;8:3822-30 pubmed
    ..We also discuss the differences in the tumorigenicity between mouse embryonic stem cells (MESCs) and HESCs, and suggest methodologies that may help to identify cellular markers for culture adapted HESCs...
  33. Nayernia K, Li M, Jaroszynski L, Khusainov R, Wulf G, Schwandt I, et al. Stem cell based therapeutical approach of male infertility by teratocarcinoma derived germ cells. Hum Mol Genet. 2004;13:1451-60 pubmed
    ..We report here in vitro generation of a germ cell line (SSC1) from the pluripotent teratocarcinoma cells by a novel promoter-based sequential selection strategy and show that the SSC1 cell line form mature ..
  34. Rotenberg B, El Hakim H, Lodha A, MacCormick A, Ngan B, Forte V. Nasopharyngeal teratocarcinosarcoma. Int J Pediatr Otorhinolaryngol. 2002;62:159-64 pubmed
    ..We present a case of a nasopharyngeal teratocarcinosarcoma associated with a cleft palate and the congenital replacement or absence of the ipsilateral Eustachian tube...
  35. Clark A, Rodriguez R, Bodnar M, Abeyta M, Cedars M, Turek P, et al. Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma. Stem Cells. 2004;22:169-79 pubmed
    ..Our characterization of STELLAR, NANOG, and GDF3 suggests that they may play a similar role in humans as in mice, in spite of their remarkable evolutionary divergence...
  36. Erdo F, Bührle C, Blunk J, Hoehn M, Xia Y, Fleischmann B, et al. Host-dependent tumorigenesis of embryonic stem cell transplantation in experimental stroke. J Cereb Blood Flow Metab. 2003;23:780-5 pubmed
  37. Borsi L, Balza E, Bestagno M, Castellani P, Carnemolla B, Biro A, et al. Selective targeting of tumoral vasculature: comparison of different formats of an antibody (L19) to the ED-B domain of fibronectin. Int J Cancer. 2002;102:75-85 pubmed
    ..Furthermore, the fact that ED-B is 100% homologous in human and mouse, which ensures that L19 reacts equally well with the human and the murine antigen, should expedite the transfer of these reagents to clinical trials...
  38. Bauerschmitz G, Nettelbeck D, Kanerva A, Baker A, Hemminki A, Reynolds P, et al. The flt-1 promoter for transcriptional targeting of teratocarcinoma. Cancer Res. 2002;62:1271-4 pubmed
    ..High transgene expression levels were detected in teratocarcinoma lines, correlating with levels of flt-1 mRNA...
  39. Marty C, Odermatt B, Schott H, Neri D, Ballmer Hofer K, Klemenz R, et al. Cytotoxic targeting of F9 teratocarcinoma tumours with anti-ED-B fibronectin scFv antibody modified liposomes. Br J Cancer. 2002;87:106-12 pubmed
    ..and in vivo by studying their biodistribution and their therapeutic potential in mice bearing subcutanous F9 teratocarcinoma tumours...
  40. Lee H, Murata J, Clair T, Polymeropoulos M, Torres R, Manrow R, et al. Cloning, chromosomal localization, and tissue expression of autotaxin from human teratocarcinoma cells. Biochem Biophys Res Commun. 1996;218:714-9 pubmed
    ..a potent human tumor cell motility-stimulating exophosphodiesterase, was isolated and cloned from the human teratocarcinoma cell line NTera2D1...
  41. Harrison N, Baker D, Andrews P. Culture adaptation of embryonic stem cells echoes germ cell malignancy. Int J Androl. 2007;30:275-81; discussion 281 pubmed
    ..Understanding the mechanisms that drive such culture adaptation of ES cells may also provide insights into the development and progression of GCT...
  42. Damjanov I. The road from teratocarcinoma to human embryonic stem cells. Stem Cell Rev. 2005;1:273-6 pubmed
    ..Most of the space will be devoted to the studies in which the author personally took part, and the discussion will also touch upon some of the crucial experiments important for the understanding of this entire research effort...
  43. Zhang H, Zhang S, Zhuang H, Lu F. Cytotoxicity of a novel fibroblast growth factor receptor targeted immunotoxin on a human ovarian teratocarcinoma cell line. Cancer Biother Radiopharm. 2006;21:321-32 pubmed
    ..The bioactivity of the product was evaluated by testing the cytotoxicity on PA-1 cells (a human ovarian teratocarcinoma cell line with high-level expression of FGFR) in vitro...
  44. Hardy M, Younkin D, Tang C, Pleasure J, Shi Q, Williams M, et al. Expression of non-NMDA glutamate receptor channel genes by clonal human neurons. J Neurochem. 1994;63:482-9 pubmed
    Treatment of the human teratocarcinoma line NTera2/c1.D1 (NT2) with retinoic acid induces terminal neuronal differentiation...
  45. Omranipour R, Alavion M. Cervical mature teratoma 17 years after initial treatment of testicular teratocarcinoma: report of a late relapse. World J Surg Oncol. 2007;5:1 pubmed
    Late relapses of testicular germ cell tumor are uncommon. We report a case of cervical mature teratoma appeared 17 years after treatment of testicular teratocarcinoma.
  46. Liu T, Lee Y, Malbon C, Wang H. Activation of the beta-catenin/Lef-Tcf pathway is obligate for formation of primitive endoderm by mouse F9 totipotent teratocarcinoma cells in response to retinoic acid. J Biol Chem. 2002;277:30887-91 pubmed
    The morphogen retinoic acid promotes the formation of primitive endoderm in mouse F9 teratocarcinoma cells as does the stimulation of the Frizzled-1 pathway...
  47. Billy E, Brondani V, Zhang H, Muller U, Filipowicz W. Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines. Proc Natl Acad Sci U S A. 2001;98:14428-33 pubmed
    ..We demonstrate that extracts prepared from EC cells catalyze processing of dsRNA into approximately 23-nt fragments and that Dicer localizes to the cytoplasm of EC and HeLa cells...
  48. Chambers I, Smith A. Self-renewal of teratocarcinoma and embryonic stem cells. Oncogene. 2004;23:7150-60 pubmed
    ..Nanog function also requires Oct4. Here, we review recent progress in ES cell self-renewal, relate this to the biology of teratocarcinomas and offer testable hypotheses to expose the mechanics of ES cell self-renewal...
  49. Thijssen V, Barkan B, Shoji H, Aries I, Mathieu V, Deltour L, et al. Tumor cells secrete galectin-1 to enhance endothelial cell activity. Cancer Res. 2010;70:6216-24 pubmed publisher
    ..Altogether, these data identify galectin-1 as a proangiogenic factor. These findings have direct implications for current efforts on galectin-1-targeted cancer therapies. ..
  50. Parrella E, Gianni M, Fratelli M, Barzago M, Raska I, Diomede L, et al. Antitumor activity of the retinoid-related molecules (E)-3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid (ST1926) and 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) in F9 teratocarcinoma: Role of retinoic acid receptor. Mol Pharmacol. 2006;70:909-24 pubmed
    ..ST1926 and CD437 are better RARgamma agonists than ATRA. We used three teratocarcinoma cell lines to evaluate the significance of RARgamma in the activity of RRMs: F9-wild type (WT); F9gamma-/-, ..
  51. Hong Y, Kim S, Bhattacharya A, Pratt D, Hong W, Tainsky M. Structure and function of the HOX A1 human homeobox gene cDNA. Gene. 1995;159:209-14 pubmed
    ..During embryonic development, the homeobox genes are both spatially and temporally regulated. In teratocarcinoma cell cultures, homeobox genes are regulated by retinoic acid (RA)...
  52. Czabanka M, Parmaksiz G, Bayerl S, Nieminen M, Trachsel E, Menssen H, et al. Microvascular biodistribution of L19-SIP in angiogenesis targeting strategies. Eur J Cancer. 2011;47:1276-84 pubmed publisher
    ..SF126 glioma and F9 teratocarcinoma cells were implanted into dorsal skin fold chambers (SF126: n = 4; F9: n = 6)...
  53. Willert J, Epping M, Pollack J, Brown P, Nusse R. A transcriptional response to Wnt protein in human embryonic carcinoma cells. BMC Dev Biol. 2002;2:8 pubmed
    ..Wnt signaling activates genes that promote stem cell fate and inhibit cellular differentiation and regulates a remarkable number of genes involved in its own signaling system. ..
  54. Kempkensteffen C, Hinz S, Jager T, Weikert S, Krause H, Schostak M, et al. [Expression levels of the IAP antagonists XAF1, Smac/DIABLO and HtrA2 in testicular germ cell tumours]. Aktuelle Urol. 2008;39:436-41 pubmed publisher
    ..We examined the mRNA-expression of these pro-apoptotic parameters in testicular germ cell tumors (TGCT) and normal testicular tissue and correlated their expression levels to clinicopathological tumour features...
  55. Min D, Shin K, Kim E, Kim S, Yoon S, Kim M, et al. Down-regulation of phospholipase D during differentiation of mouse F9 teratocarcinoma cells. FEBS Lett. 1999;454:197-200 pubmed
    ..We investigated the expression of phospholipase D during the differentiation of F9 embryonal teratocarcinoma cells...
  56. Ferreiro E, Costa R, Marques S, Cardoso S, Oliveira C, Pereira C. Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP(106-126). J Neurochem. 2008;104:766-76 pubmed
    ..pathway triggered by the PrP peptide, we investigated the effects of PrP(106-126) on the Ntera2 human teratocarcinoma cell line that had been depleted of their mitochondrial DNA, termed NT2 rho0 cells, characterized by the ..
  57. Lensch M, Ince T. The terminology of teratocarcinomas and teratomas. Nat Biotechnol. 2007;25:1211; author reply 1211-2 pubmed
  58. Niesner U, Halin C, Lozzi L, Gunthert M, Neri P, Wunderli Allenspach H, et al. Quantitation of the tumor-targeting properties of antibody fragments conjugated to cell-permeating HIV-1 TAT peptides. Bioconjug Chem. 2002;13:729-36 pubmed
    ..severely reduced tumor targeting performance compared to the unconjugated antibody, as measured in murine F9 teratocarcinoma-bearing mice, after intravenous injection of the radiolabeled antibody preparations...