ganglioneuroblastoma

Summary

Summary: A moderately malignant neoplasm composed of primitive neuroectodermal cells dispersed in myxomatous or fibrous stroma intermixed with mature ganglion cells. It may undergo transformation into a neuroblastoma. It arises from the sympathetic trunk or less frequently from the adrenal medulla, cerebral cortex, and other locations. Cervical ganglioneuroblastomas may be associated with HORNER SYNDROME and the tumor may occasionally secrete vasoactive intestinal peptide, resulting in chronic diarrhea.

Top Publications

  1. Goto S, Umehara S, Gerbing R, Stram D, Brodeur G, Seeger R, et al. Histopathology (International Neuroblastoma Pathology Classification) and MYCN status in patients with peripheral neuroblastic tumors: a report from the Children's Cancer Group. Cancer. 2001;92:2699-708 pubmed
    ..MYCN amplification is a known molecular marker for aggressive progression of NTs. These have been used together as important prognostic factors to define risk groups for patient stratification and protocol assignment...
  2. Izbicki T, Mazur J, Izbicka E. Epidemiology of neuroblastoma: analysis of a single institution. Anticancer Res. 2003;23:1933-8 pubmed
    ..Neuroblastoma is the fourth most frequent cancer among all pediatric neoplasms Epidemiological studies may shed more light on the disease and aid in improving treatment of patients with neuroblastoma...
  3. Satoh F, Takahashi K, Murakami O, Totsune K, Sone M, Ohneda M, et al. Adrenomedullin in human brain, adrenal glands and tumor tissues of pheochromocytoma, ganglioneuroblastoma and neuroblastoma. J Clin Endocrinol Metab. 1995;80:1750-2 pubmed
    ..subjects by radioimmunoassay, as well as in the human adrenal glands and tumor tissues of pheochromocytoma, ganglioneuroblastoma and neuroblastoma. Immunoreactive adrenomedullin was detected in every region of human brain examined (0...
  4. George R, Variend S, Cullinane C, Cotterill S, McGuckin A, Ellershaw C, et al. Relationship between histopathological features, MYCN amplification, and prognosis: a UKCCSG study. United Kingdom Children Cancer Study Group. Med Pediatr Oncol. 2001;36:169-76 pubmed
    ..Most MYCN-amplified tumours have unfavourable histology and a poorer prognosis. However, in patients with stage 4 disease and those over the age of 1 year, other factors that may influence prognosis should be determined...
  5. Sossey Alaoui K, Su G, Malaj E, Roe B, Cowell J. WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma. Oncogene. 2002;21:5967-74 pubmed
    ..b>Ganglioneuroblastoma is a relatively benign form of Nb and consists of a mixture of fibrils, mature and maturing ganglion cells, ..
  6. Rha S, Byun J, Jung S, Chun H, Lee H, Lee J. Neurogenic tumors in the abdomen: tumor types and imaging characteristics. Radiographics. 2003;23:29-43 pubmed
    ..However, because most neurogenic tumors in adults are benign, CT and MR imaging can be used to develop a differential diagnosis and help determine the immediate local extent of tumor...
  7. Coco S, Defferrari R, Scaruffi P, Cavazzana A, Di Cristofano C, Longo L, et al. Genome analysis and gene expression profiling of neuroblastoma and ganglioneuroblastoma reveal differences between neuroblastic and Schwannian stromal cells. J Pathol. 2005;207:346-57 pubmed
    ..Neuroblastoma (Schwannian stroma-poor) (NB-SP) is composed of undifferentiated neuroblasts. Ganglioneuroblastoma intermixed (Schwannian stroma-rich) (GNBi-SR) is predominantly composed of Schwannian stromal (SS) and ..
  8. Spugnini E, Citro G, Dotsinsky I, Mudrov N, Mellone P, Baldi A. Ganglioneuroblastoma in a cat: a rare neoplasm treated with electrochemotherapy. Vet J. 2008;178:291-3 pubmed
    ..A diagnosis of ganglioneuroblastoma was suggested by the tumour appearance following histopathological staining with haematoxylin and eosin and ..
  9. Gahr N, Darge K, Hahn G, Kreher B, von Buiren M, Uhl M. Diffusion-weighted MRI for differentiation of neuroblastoma and ganglioneuroblastoma/ganglioneuroma. Eur J Radiol. 2011;79:443-6 pubmed publisher
    The purpose of this study was to assess the apparent diffusion coefficient (ADC) of neuroblastic tumours and to evaluate if the ADC can enable differentiation of neuroblastoma and ganglioneuroma/ganglioneuroblastoma.

More Information

Publications119 found, 100 shown here

  1. Wilzén A, Krona C, Sveinbjörnsson B, Kristiansson E, Dalevi D, Øra I, et al. ERBB3 is a marker of a ganglioneuroblastoma/ganglioneuroma-like expression profile in neuroblastic tumours. Mol Cancer. 2013;12:70 pubmed publisher
    ..In the current study we characterized these different subgroups in more detail, with a specific focus on the fourth divergent tumour subgroup (r4)...
  2. Toraman A, Keser I, Luleci G, Tunali N, Gelen T. Comparative genomic hybridization in ganglioneuroblastomas. Cancer Genet Cytogenet. 2002;132:36-40 pubmed
    The ganglioneuroblastoma are rare lesions with widespread neuronal differentiation that have been classified as intermediate stages between neuroblastoma and ganglioneuroma...
  3. Peuchmaur M, D Amore E, Joshi V, Hata J, Roald B, Dehner L, et al. Revision of the International Neuroblastoma Pathology Classification: confirmation of favorable and unfavorable prognostic subsets in ganglioneuroblastoma, nodular. Cancer. 2003;98:2274-81 pubmed
    b>Ganglioneuroblastoma, nodular (GNBn) comprises one of the categories of peripheral neuroblastic tumors...
  4. Hsiao C, Huang C, Sheen J, Tai M, Chen C, Huang L, et al. Differential expression of delta-like gene and protein in neuroblastoma, ganglioneuroblastoma and ganglioneuroma. Mod Pathol. 2005;18:656-62 pubmed
    ..expression were studied in formalin-fixed archival tissues from 10 patients with neuroblastoma, five with ganglioneuroblastoma, and five with ganglioneuroma...
  5. Peuchmaur M. [Peripheral neuroblastic tumors: anatomo pathological classification]. Ann Pathol. 2004;24:556-67 pubmed
    ..subtypes: 1/Neuroblastoma stroma poor, undifferentiated, poorly differentiated, and differentiating, 2/ganglioneuroblastoma stroma composite, nodular, 3/ganglioneuroblastoma stroma composite, intermixed and 4/ganglioneuromas stroma ..
  6. Schulte J, Pentek F, Hartmann W, Schramm A, Friedrichs N, Øra I, et al. The low-affinity neurotrophin receptor, p75, is upregulated in ganglioneuroblastoma/ganglioneuroma and reduces tumorigenicity of neuroblastoma cells in vivo. Int J Cancer. 2009;124:2488-94 pubmed publisher
  7. Angelini P, London W, Cohn S, Pearson A, Matthay K, Monclair T, et al. Characteristics and outcome of patients with ganglioneuroblastoma, nodular subtype: a report from the INRG project. Eur J Cancer. 2012;48:1185-91 pubmed publisher
    Describe characteristics and outcome of INRG patients with ganglioneuroblastoma, nodular subtype (GNBn).
  8. Duijkers F, Gaal J, Meijerink J, Admiraal P, Pieters R, de Krijger R, et al. High anaplastic lymphoma kinase immunohistochemical staining in neuroblastoma and ganglioneuroblastoma is an independent predictor of poor outcome. Am J Pathol. 2012;180:1223-31 pubmed publisher
    ..the prognostic relevance of ALK positivity by IHC and ALK mutation status by PCR sequencing in 71 NBL, 12 ganglioneuroblastoma (GNBL), and 20 ganglioneuroma samples in a multivariate model...
  9. Schipper M, van Duinen S, Taphoorn M, Kloet A, Walchenbach R, Wiggenraad R, et al. Cerebral ganglioneuroblastoma of adult onset: two patients and a review of the literature. Clin Neurol Neurosurg. 2012;114:529-34 pubmed publisher
    b>Ganglioneuroblastoma is a rare tumor variant of neuroblastoma. Only five cases have been observed in the adult brain, and we report here on two more adult patients with cerebral ganglioneuroblastoma...
  10. Wang M, Zhou C, Cai R, Li Y, Gong L. Copy number gain of MYCN gene is a recurrent genetic aberration and favorable prognostic factor in Chinese pediatric neuroblastoma patients. Diagn Pathol. 2013;8:5 pubmed publisher
    ..But copy number analyses of MYCN gene in ganglioneuroblastoma (GNBL) and ganglioneuroma(GN) is poorly described in the literature...
  11. Lonergan G, Schwab C, Suarez E, Carlson C. Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation. Radiographics. 2002;22:911-34 pubmed
    Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma are tumors of the sympathetic nervous system that arise from primitive sympathogonia and are referred to collectively as neuroblastic tumors...
  12. Ramadan M, Whalen B, De Santes K. Hyperexcitable blink reflex preceding the diagnosis of neuroblastoma. J Pediatr Hematol Oncol. 2004;26:665-7 pubmed
  13. McHugh K. Renal and adrenal tumours in children. Cancer Imaging. 2007;7:41-51 pubmed
  14. Neuzillet C, Hammel P, Baudin E, Couvelard A, Elias D, Casiraghi O, et al. [Verner-Morrison syndrome revealing a ganglioneuroblastoma in an adult]. Gastroenterol Clin Biol. 2008;32:282-8 pubmed publisher
    ..We report here the case of a Verner-Morrison syndrome in a 40-year-old woman revealing a metastatic ganglioneuroblastoma. The diarrhea resolved after the resection of primary tumour and liver metastases...
  15. Yamanaka M, Saitoh F, Saitoh H, Nisimura S, Sawada Y, Tsukui A, et al. Primary retroperitoneal ganglioneuroblastoma in an adult. Int J Urol. 2001;8:130-2 pubmed
    A case of retroperitoneal ganglioneuroblastoma in a 60-year-old man is reported. This retroperitoneal tumor was surgically removed and pathologic diagnosis was ganglioneuroblastoma...
  16. Vanchinathan V, Marinelli E, Kartha R, Uzieblo A, Ranchod M, Sundram U. A malignant cutaneous neuroendocrine tumor with features of Merkel cell carcinoma and differentiating neuroblastoma. Am J Dermatopathol. 2009;31:193-6 pubmed publisher
    ..primary cutaneous neuroendocrine carcinoma that shows histologic and immunohistochemical features of ganglioneuroblastoma/differentiating neuroblastoma...
  17. Maugeri G, D Amico A, Rasà D, Reitano R, Saccone S, Federico C, et al. Expression profile of Wilms Tumor 1 (WT1) isoforms in undifferentiated and all-trans retinoic acid differentiated neuroblastoma cells. Genes Cancer. 2016;7:47-58 pubmed
    ..that neuroblastoma may undergo maturation, by transforming itself in a more differentiated tumors such as ganglioneuroblastoma and ganglioneuroma, or progressing into a highly aggressive metastatic malignancy...
  18. Schiavetti A, Ingrosso A, Picone S, Boscherini B. Growth hormone deficiency after localized ganglioneuroblastoma: A case report. J Pediatr Hematol Oncol. 2006;28:625-6 pubmed
    ..We report on a case of localized ganglioneuroblastoma treated by carboplatin/etoposide for 2 courses and surgery, which developed a serious GHD after 56 months...
  19. Wildhaber B, Niggli F, Bergsträsser E, Stallmach T, Sacher P. Paraneoplastic syndromes in ganglioneuroblastoma: contrasting symptoms of constipation and diarrhoea. Eur J Pediatr. 2003;162:511-513 pubmed publisher
    ..Either severe diarrhoea or chronic constipation may represent rare paraneoplastic syndromes in ganglioneuroblastomas. ..
  20. Grayson W. Recurrent and metastatic ganglioneuroblastic melanoma with terminal rhabdoid phenotype. Am J Dermatopathol. 2003;25:359-60 pubmed
  21. Vlachou M, Verikokakis A, Grivas T, Dimitriadis D. Treatment of severe thoracolumbar kyphoscoliosis on the ground of ganglioneuroblastoma of the diaphragm: a case report. J Pediatr Orthop B. 2012;21:155-9 pubmed publisher
    ..of an unusual case with severe kyphoscoliotic deformity of the thoracolumbar spine, in association with a ganglioneuroblastoma invading the adjacent diaphragm, is presented in this report...
  22. Huang S, Alaggio R, Sung Y, Chen C, Zhang L, Kao Y, et al. Frequent HRAS Mutations in Malignant Ectomesenchymoma: Overlapping Genetic Abnormalities With Embryonal Rhabdomyosarcoma. Am J Surg Pathol. 2016;40:876-85 pubmed publisher
    ..The intermixed neuroectodermal components were mostly scattered ganglion cells, ganglioneuroma, or ganglioneuroblastoma. By Sanger sequencing, 6 of 7 (86%) MEMs had HRAS mutations, with no additional case harboring PTPRD or ..
  23. Beniashvili D, Anisimov V. [Induction of tumors of the sympathetic nervous system in rats]. Vopr Onkol. 2002;48:52-6 pubmed
  24. Zangeneh F, Young W, Lloyd R, Chiang M, Kurczynski E, Zangeneh F. Cushing's syndrome due to ectopic production of corticotropin-releasing hormone in an infant with ganglioneuroblastoma. Endocr Pract. 2003;9:394-9 pubmed
    ..the first recognized case of Cushing's syndrome due to a corticotropin-releasing hormone (CRH)-secreting ganglioneuroblastoma, which was found in an 18-month-old boy with hypertensive encephalopathy...
  25. Retrosi G, Sebire N, Bishay M, Kiely E, Anderson J, De Coppi P, et al. Brain lipid-binding protein: a marker of differentiation in neuroblastic tumors. J Pediatr Surg. 2011;46:1197-200 pubmed publisher
    Neuroblastoma (NB), ganglioneuroblastoma (GNB), and ganglioneuroma (GN) are neuroblastic tumours (NT) of sympathetic nervous system origin...
  26. Shida Y, Igawa T, Abe K, Hakariya T, Takehara K, Onita T, et al. Composite pheochromocytoma of the adrenal gland: a case series. BMC Res Notes. 2015;8:257 pubmed publisher
    ..laparoscopic right adrenalectomy, and pathological examination revealed composite pheochromocytoma-ganglioneuroblastoma. Although the Ki67-positive rates varied from 1.0 to 6...
  27. Frappaz D, Giammarile F, Thiesse P, Ranchere Vince D, Louis D, Guibaud L, et al. False positive MIBG scan. Med Pediatr Oncol. 1997;29:589-92 pubmed
    ..Metaiodobenzylguanidine (MIBG) uptake suggested a sympathetic tissue origin of the mass despite negative catecholamines excretion, but histopathologic examination revealed a juvenile capillary angioma within a normal sympathic ganglion. ..
  28. Bosdure E, Attarian S, Mancini J, Mikaeloff Y, Chabrol B. [Lambert-Eaton myastenic syndrome revealing neuroblastoma in 2 children]. Arch Pediatr. 2006;13:1121-4 pubmed
    ..This disease is extremely rare in children. Only 10 cases have been reported in the last 35 years. We report 2 new observations occurring in very young patients, aged 2 and 3 years, with a ganglioneurobastoma as primitive tumor...
  29. McMahon S, Menon S, McDowell D, Yeap B, Russell J, Corbally M. The use of the trapdoor incision for access to thoracic inlet pathology in children. J Pediatr Surg. 2013;48:1147-51 pubmed publisher
    ..We report our experience of four cases where a trapdoor incision was used to gain excellent access and exposure to thoracic inlet pathology in children. ..
  30. Posner J. Paraneoplastic syndromes in neuroblastoma. J Pediatr Hematol Oncol. 2004;26:553-4 pubmed
  31. Ulrich R, Stan A, Koch A, Beineke A. Expression of brain-derived neurotrophic factor and tropomyosin-related kinase-B in a bovine jejunal nodular ganglioneuroblastoma. Vet Pathol. 2008;45:355-60 pubmed publisher
    This report describes the morphologic, ultrastructural, and immunophenotypic features of a nodular ganglioneuroblastoma in the jejunum of a 13-month-old Holstein-Friesian heifer...
  32. Kurt E, Filiz G, Vuruskan H, Kurt M, Evrensel T. Life-threatening complications of an extremely rare tumor of the kidney: adult-type primary renal ganglioneuroblastoma. South Med J. 2007;100:852-3 pubmed
  33. Lucaccioni L, Bigi E, Garcinuno C, Paolucci P, Iughetti L. Incidental diagnosis of thoracic ganglioneuroblastoma in a 3-year-old female with wheezing. Acta Biomed. 2012;83:53-5 pubmed
    b>Ganglioneuroblastoma (GNB) is a cancer of the peripheral sympathetic nervous system and represents the 30% of cases of Neuroblastoma...
  34. Karabayir N, Demirkol D, Al I, Dolaş I, Sencer A. Subarachnoid-pleural fistula in a child: the cause and treatment. Pediatr Int. 2012;54:929-31 pubmed publisher
    ..A two years and four months old boy who was operated because of ganglioneuroblastoma was admitted to hospital due to respiratory distress...
  35. Nakazato Y, Hosaka N. A 32-year-old man with left temporal lobe tumor. Neuropathology. 2004;24:261-2 pubmed
  36. Beniashvili D, Anisimov V. Morphology of experimentally induced tumors of the sympathetic nervous system in rats. Exp Toxicol Pathol. 2004;56:53-8 pubmed
    ..These tumors were classified as follows: benign--ganglioneuroma (six cases) and malignant--ganglioneuroblastoma (four cases) and neuroblastoma (seven cases)...
  37. Jin Y, Wang H, Han W, Lu J, Chu P, Han S, et al. Single nucleotide polymorphism rs11669203 in TGFBR3L is associated with the risk of neuroblastoma in a Chinese population. Tumour Biol. 2016;37:3739-47 pubmed publisher
    ..of Chinese origin with neuroblastic family tumors, including neuroblastoma (NB), ganglioneuroma (GN), and ganglioneuroblastoma (GNB), and in 290 cancer-free controls to determine whether any of the tested SNPs are associated with ..
  38. Jackson J, Tran H, Stein J, Shimada H, Patel A, Marachelian A, et al. The clinical management and outcomes of cervical neuroblastic tumors. J Surg Res. 2016;204:109-13 pubmed publisher
    ..Twelve patients (3.6%) were found to have cervical neuroblastic tumors (nine NBs, one ganglioneuroblastoma, and two ganglioneuromas). All had favorable histology, and none (0/12) had MYCN amplification...
  39. Sousa N, Marques de Oliveira L, Cortez P, Valenti V, Garner D, Irulegui R, et al. A rare case of Ganglioneuroblastoma Encapsulated in Pheochromocytoma. Acta Medica (Hradec Kralove). 2016;59:67-9 pubmed publisher
    Pheochromocytoma and Ganglioneuroblastoma are separate diseases and a rare combination in which the diagnosis can only be confirmed by pathological examination after tumor excision...
  40. Catalina Fernandez I, Sáenz Santamaria J, López Presa D. Fine needle aspiration cytology of ganglioneuroma. Acta Cytol. 2008;52:380-1 pubmed
  41. Magro G, Salvatorelli L, Alaggio R, D Agata V, Nicoletti F, Di Cataldo A, et al. Diagnostic utility of cyclin D1 in the diagnosis of small round blue cell tumors in children and adolescents. Hum Pathol. 2017;60:58-65 pubmed publisher
    ..peripheral neuroectodermal tumor (EWS/pPNET) and peripheral neuroblastic tumors (neuroblastoma and ganglioneuroblastoma), we immunohistochemically assessed cyclin D1 immunoreactivity in 128 cases of SRBCTs in children and ..
  42. Kuwamura M, Kotera T, Yamate J, Kotani T, Aoki M, Hori A. Cerebral ganglioneuroblastoma in a golden retriever dog. Vet Pathol. 2004;41:282-4 pubmed
    ..Based on morphologic and immunohistochemical features, the diagnosis of cerebral ganglioneuroblastoma was made...
  43. Lin X, Wu D, Chen C, Zheng N. Clinical characteristics of adrenal tumors in children: a retrospective review of a 15-year single-center experience. Int Urol Nephrol. 2017;49:381-385 pubmed publisher
    ..Adrenomedullary tumors were 37, including 24 cases of neuroblastoma, 10 cases of ganglioneuroma, 2 cases of ganglioneuroblastoma, and 1 case of pheochromocytoma...
  44. Nakagawara A, Nakamura Y, Ikeda H, Hiwasa T, Kuida K, Su M, et al. High levels of expression and nuclear localization of interleukin-1 beta converting enzyme (ICE) and CPP32 in favorable human neuroblastomas. Cancer Res. 1997;57:4578-84 pubmed
    ..Our results suggest that ICE and CPP32 cysteine proteases may play an important role in regulating the apoptotic process of the favorable neuroblastomas. ..
  45. Nio M, Nakamura M, Yoshida S, Ishii T, Amae S, Hayashi Y. Thoracoscopic removal of neurogenic mediastinal tumors in children. J Laparoendosc Adv Surg Tech A. 2005;15:80-3 pubmed
    ..0-2.5 cm in each case. Pathologic diagnosis was neuroblastoma in 1 patient, ganglioneuroblastoma in 2, and ganglioneuroma in 3 patients. The mean operative time was 230 minutes...
  46. Lara Bohorquez C, Gonzalez Campora R, Mendoza García E, Ríos Martín J, Pareja Megia M, Lopez Beltran A. TP53, BCL-2, p21Waf1/Cip1 and metallothionein as markers of differentiation, response to treatment and prognosis in neuroblastic tumors. Anal Quant Cytol Histol. 2008;30:105-12 pubmed
    ..TP53, BCL-2, p21Waf1/Cip1 and metallothionein had limited value reflecting tumor maturation (differentiation) or predicting response to therapy. Only nuclear TP53 accumulation may be relevant in patient's prognosis. ..
  47. Ramani P, Headford A, May M. GLUT1 protein expression correlates with unfavourable histologic category and high risk in patients with neuroblastic tumours. Virchows Arch. 2013;462:203-9 pubmed publisher
    ..Our data may have clinical significance because GLUT1 was also present in a higher proportion of high-risk NTs. ..
  48. Shimada H, Umehara S, Monobe Y, Hachitanda Y, Nakagawa A, Goto S, et al. International neuroblastoma pathology classification for prognostic evaluation of patients with peripheral neuroblastic tumors: a report from the Children's Cancer Group. Cancer. 2001;92:2451-61 pubmed
    ..The International Neuroblastoma Pathology Classification was established in 1999 for the prognostic evaluation of patients with neuroblastic tumors (NTs)...
  49. Reindl T, Degenhardt P, Luck W, Riebel T, Sarioglu N, Henze G, et al. [The VIP-secreting tumor as a differential diagnosis of protracted diarrhea in pediatrics]. Klin Padiatr. 2004;216:264-9 pubmed
    ..We report on two patients with ganglioneuroblastoma and secretory diarrhea...
  50. Mody R, Naranjo A, Van Ryn C, Yu A, London W, Shulkin B, et al. Irinotecan-temozolomide with temsirolimus or dinutuximab in children with refractory or relapsed neuroblastoma (COG ANBL1221): an open-label, randomised, phase 2 trial. Lancet Oncol. 2017;18:946-957 pubmed publisher
    ..Oncology Group (COG; ANBL1221), patients had to have histological verification of neuroblastoma or ganglioneuroblastoma at diagnosis or have tumour cells in bone marrow with increased urinary catecholamine concentrations at ..
  51. Masumoto K, Arima T, Izaki T, Takahashi Y, Honda N, Toyoshima S, et al. Ondine's curse associated with Hirschsprung disease and ganglioneuroblastoma. J Pediatr Gastroenterol Nutr. 2002;34:83-6 pubmed
  52. Tabyaoui I, Tahiri Jouti N, Serhier Z, Bennani Othmani M, Sibai H, Itri M, et al. Immunohistochemical expression of CD44s in human neuroblastic tumors: Moroccan experience and highlights on current data. Diagn Pathol. 2013;8:39 pubmed publisher
    Peripheral neuroblastic tumors (pNTs), including neuroblastoma (NB), ganglioneuroblastoma (GNB) and ganglioneuroma (GN), are extremely heterogeneous pediatric tumors responsible for 15 % of childhood cancer death...
  53. Alvi S, Karadaghy O, Manalang M, Weatherly R. Clinical manifestations of neuroblastoma with head and neck involvement in children. Int J Pediatr Otorhinolaryngol. 2017;97:157-162 pubmed publisher
    ..The hospital tumor database was analyzed to identify patients with neuroblastoma, ganglioneuroblastoma, and esthesioneuroblastoma diagnosed between 1997 and 2012...
  54. Teitz T, Inoue M, Valentine M, Zhu K, Rehg J, Zhao W, et al. Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis. Cancer Res. 2013;73:4086-97 pubmed publisher
    ..Cytokine TGF-? can preferentially promote single cell motility and blood-borne metastasis and therefore activation of this pathway may explain the enhanced bone marrow metastasis observed in this animal model. ..
  55. Takama Y, Yoneda A, Nakamura T, Nakaoka T, Higashio A, Santo K, et al. Early Detection and Treatment of Neuroblastic Tumor with Opsoclonus-Myoclonus Syndrome Improve Neurological Outcome: A Review of Five Cases at a Single Institution in Japan. Eur J Pediatr Surg. 2016;26:54-9 pubmed publisher
    ..The tumor histopathology was neuroblastoma in two patients, ganglioneuroblastoma in two patients, and ganglioneuroma in one patient. Primary resection was performed in three cases...
  56. Sirignano M, Dillman J, WEISS B, Quinn C, Zhang B, Su W, et al. Change in liver, spleen and bone marrow magnetic resonance imaging signal intensity over time in children with solid abdominal tumors. Pediatr Radiol. 2018;48:325-332 pubmed publisher
    ..MR images obtained December 2009 through February 2016 in children with hepatoblastoma, neuroblastoma, ganglioneuroblastoma and Wilms tumor. All signal intensity measurements were normalized to paraspinal muscle signal intensity...
  57. Gluer S, Zense M, Radtke E, von Schweinitz D. [Expression of polysialylated NCAM on neuroblastomas of various histology and clinical stages]. Langenbecks Arch Chir Suppl Kongressbd. 1998;115:289-92 pubmed
    ..Since PSA-NCAM serum concentrations correlate to the amount of PSA-NCAM positive tumor cells, we conclude that PSA-NCAM is a new useful diagnostic and prognostic marker for childhood neuroblastoma. ..
  58. Akgun B, Ates D, Kaplan M. Ganglioneuroblastoma of the thoracic spinal cord: a very rare case report. Acta Medica (Hradec Kralove). 2012;55:50-2 pubmed
    ..Histopathological properties were compatible with the intermixed subtype of ganglioneuroblastoma. Only a limited number of thoracic cord Ganglioneuroblastoma reports have been previously published...
  59. Mejia C, Navarro S, Pellin A, Ruiz A, Castel V, Llombart Bosch A. Prognostic significance of cell proliferation in human neuroblastoma: comparison with other prognostic factors. Oncol Rep. 2003;10:243-7 pubmed
    Peripheral neuroblastic tumors (PNT), are heterogeneous neoplasms that include neuroblastoma (NB), ganglioneuroblastoma (GNB) and ganglioneuroma (GN) and present great biological heterogeneity...
  60. Abe T, Goda M, Kamida T, Fujiki M, Kobayashi H, Nakano T, et al. Overlapping free bone graft with galea-pericranium in reconstruction of the anterior skull base to prevent CSF leak and sequestrum formation. Acta Neurochir (Wien). 2007;149:771-5; discussion 775 pubmed
    ..Conclusion. Three dimensional computed tomography (3D-CT) at bone window settings demonstrated the bone graft covered the bone defect and was not absorbed and after 11 years there have been no signs of tumour regrowth or complications. ..
  61. Lam A. Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours. Endocr Pathol. 2017;28:213-227 pubmed publisher
    ..head and neck paraganglioma and sympathetic paraganglioma), neuroblastic tumours (neuroblastoma, nodular ganglioneuroblastoma, intermixed ganglioneuroblastoma, and ganglioneuroma), composite pheochromocytoma, and composite ..
  62. Mitchell W, Blaes F. Cancer and Autoimmunity: Paraneoplastic Neurological Disorders Associated With Neuroblastic Tumors. Semin Pediatr Neurol. 2017;24:180-188 pubmed publisher
    ..but the most common of these rare disorders are instigated by neuroblastic tumors, such as neuroblastoma, ganglioneuroblastoma, and ganglioneuroma...
  63. Pai Balaji S, Shetty N, Mahadevan A, Shankar S. A 21-month-old child with acute spastic parapapresis. Brain Pathol. 2008;18:105-7, 143 pubmed publisher
  64. Vallat Decouvelaere A, Gauchez P, Varlet P, Delisle M, Popovic M, Boissonnet H, et al. So-called malignant and extra-ventricular neurocytomas: reality or wrong diagnosis? A critical review about two overdiagnosed cases. J Neurooncol. 2000;48:161-72 pubmed
    ..such as ours is not easy: the diagnoses finally retained were oligodendroglioma in the first case and ganglioneuroblastoma in the second case...
  65. Wu X, Zhu M, Zhang Z. [Expression of KAI1/CD82 in neuroblastoma and its correlation to prognosis]. Ai Zheng. 2005;24:885-9 pubmed
    ..was used to detect the expression of KAI1/CD82 in 90 specimens of neuroblastoma (28 specimens of ganglioneuroblastoma and 62 specimens of neuroblastoma). Clinical data and follow-up data of the 90 patients were analyzed...
  66. Pranzatelli M, Tate E, Shenoy S, Travelstead A. Ofatumumab for a rituximab-allergic child with chronic-relapsing paraneoplastic opsoclonus-myoclonus. Pediatr Blood Cancer. 2012;58:988-91 pubmed publisher
    ..He had relapsed despite chemotherapy, plasma exchange with immunoadsorption, and resection of ganglioneuroblastoma, detected 3 years after OMS onset...
  67. Garcia J, Faca V, Jarzembowski J, Zhang Q, Park J, Hanash S. Comprehensive profiling of the cell surface proteome of Sy5Y neuroblastoma cells yields a subset of proteins associated with tumor differentiation. J Proteome Res. 2009;8:3791-6 pubmed publisher
    ..This comprehensive neuroblastoma cell surface profile has identified novel potential markers for neuroblastoma classification and novel potential targets for therapy. ..
  68. Guarino S, Astini C, Howard J, Colombelli V. Large mediastinal nodular ganglioneuroblastoma in a child from Africa. Ann Ital Chir. 2012;83:543-6 pubmed
    b>Ganglioneuroblastoma, nodular (GNBn) is a subtype of neuroblastic tumors. This is a rare malignancy typically affecting young children. Few cases are reported in adolescents and adults...
  69. Yoneda A, Oue T, Imura K, Inoue M, Yagi K, Kawa K, et al. Observation of untreated patients with neuroblastoma detected by mass screening: a "wait and see" pilot study. Med Pediatr Oncol. 2001;36:160-2 pubmed
    ..Therefore, we started an observation program for these patients to determine how frequently spontaneous regression occurs...
  70. Averbuch D, Boekhoutt T, Falk R, Engelhard D, Shapiro M, Block C, et al. Fungemia in a cancer patient caused by fluconazole-resistant Cryptococcus laurentii. Med Mycol. 2002;40:479-84 pubmed
    We report the recent isolation of Cryptococcus laurentii from the blood of a patient given the diagnosis of ganglioneuroblastoma. The organism was identified using physiological and molecular characteristics, including morphology, ..
  71. Hu H, He L. [Study on MYCN gene amplification and CD44 expression in neuroblastoma]. Zhonghua Bing Li Xue Za Zhi. 2004;33:332-6 pubmed
    ..To assess the relationship between MYCN amplification in neuroblastoma (NB), tumor stage and prognosis; and to evaluate the usefulness of CD44 in predicting prognosis of NB...
  72. Ito A, Uno T, Gunji Y, Yamauchi T, Egami S, Kawarasaki H, et al. Obstructive jaundice as a presentation of ganglioneuroblastoma. J Pediatr Hematol Oncol. 2005;27:112-4 pubmed
    ..The authors report a case of ganglioneuroblastoma presenting with obstructive jaundice as a rare initial feature...
  73. Meyer J, Siegel M, Farooqui S, Jaramillo D, Fletcher B, Hoffer F. Which MRI sequence of the spine best reveals bone-marrow metastases of neuroblastoma?. Pediatr Radiol. 2005;35:778-85 pubmed
    ..MRI is an effective tool in evaluating bone marrow metastases. However, no study has defined which MRI sequences or image characteristics best correlate with bone-marrow metastases in neuroblastoma...
  74. Cardesa Salzmann T, Mora J, García Cazorla M, Cruz O, Munoz C, Campistol J. Epstein-Barr virus related opsoclonus-myoclonus-ataxia does not rule out the presence of occult neuroblastic tumors. Pediatr Blood Cancer. 2006;47:964-7 pubmed
    ..We present the case of a 20-month-old child with OMA associated with a microbiologically documented acute EBV infection and an occult thoracic ganglioneuroblastoma diagnosed 5 months later.
  75. Turkel S, Brumm V, Mitchell W, Tavare C. Mood and behavioral dysfunction with opsoclonus-myoclonus ataxia. J Neuropsychiatry Clin Neurosci. 2006;18:239-41 pubmed
    ..Psychiatric symptoms examined included disruptive behavior, affective dysregulation, irritability, impulsivity, cognitive impairment, and poor attention...
  76. Gasparetto E, Rosemberg S, Matushita H, Leite C. Ganglioneuroblastoma of the cerebellum: neuroimaging and pathological features of a case. Arq Neuropsiquiatr. 2007;65:338-40 pubmed
    To report a case of ganglioneuroblastoma of cerebellum, with emphasis to the neuroimaging and pathological findings.
  77. Banelli B, Bonassi S, Casciano I, Mazzocco K, di Vinci A, Scaruffi P, et al. Outcome prediction and risk assessment by quantitative pyrosequencing methylation analysis of the SFN gene in advanced stage, high-risk, neuroblastic tumor patients. Int J Cancer. 2010;126:656-68 pubmed publisher
    ..Our results lead to the hypothesis that a subset of patients considered at high risk-but displaying low levels of methylation-could be assigned at a lower risk group...
  78. Okumi M, Ueda T, Ichimaru N, Fujimoto N, Itoh K. [A case of composite pheochromocytoma-ganglioneuroblastoma in the adrenal gland with primary hyperparathyroidism]. Hinyokika Kiyo. 2003;49:269-72 pubmed
    We report a case of composite pheochromocytoma-ganglioneuroblastoma in the adrenal gland with primary hyperparathyrodisim...
  79. Gesundheit B, Smith C, Gerstle J, Weitzman S, Chan H. Ataxia and secretory diarrhea: two unusual paraneoplastic syndromes occurring concurrently in the same patient with ganglioneuroblastoma. J Pediatr Hematol Oncol. 2004;26:549-52 pubmed
    ..The diarrhea resolved after tumor resection, whereas OMA required further therapy. Increased awareness of VIP-secretory diarrhea, especially in an ataxic child, might contribute to an earlier diagnosis of neuroblastoma...
  80. Gunlusoy B, Arslan M, Selek E, Sural S, Ayder A. A case report: adrenal ganglioneuroblastoma in a 59-year old man. Int Urol Nephrol. 2004;36:481-3 pubmed
    b>Ganglioneuroblastoma is a common type of tumor in children, but is rarely seen in adults. We present here a case of adrenal ganglioneuroblastoma in a 59-year old man.
  81. Daneshbod Y, Khojasteh H, Zamiri B, Daneshbod K. Metastatic ganglioneuroblastoma in head and neck diagnosed by fine needle aspiration: a case report. Acta Cytol. 2007;51:429-33 pubmed
    To describe the cytologic findings of a case of ganglioneuroblastoma metastatic to the jaw and neck.
  82. Winter C, Pawel B, Seiser E, Zhao H, Raabe E, Wang Q, et al. Neural cell adhesion molecule (NCAM) isoform expression is associated with neuroblastoma differentiation status. Pediatr Blood Cancer. 2008;51:10-6 pubmed publisher
    ..While highly expressed on neuroblastoma cells, the relative contribution of the three major NCAM isoforms (120, 140, and 180 kDa) to neuroblastoma biology has not been investigated...
  83. La Rosa C, Baroncelli G, Pavone P, Praticò A, Di Cataldo A, Caruso Nicoletti M. Ganglioneuroblastoma-associated vitamin D deficiency rickets. J Pediatr Hematol Oncol. 2009;31:502-4 pubmed publisher
    ..South of Italy he underwent several investigations, which demonstrated the association with an abdominal ganglioneuroblastoma. To our knowledge, ganglioneuroblastoma has never been reported in association with vitamin D deficiency ..
  84. Okita Y, Narita Y, Yoshida A, Miyakita Y, Ohno M, Saio M, et al. The late recurrence of ganglioneuroma 21 years after initial presentation with neuroblastoma. Pediatr Hematol Oncol. 2012;29:647-51 pubmed
    ..After chemotherapy, the tumors were resected and the pathological diagnoses of ganglioneuroblastoma in the adrenal gland and ganglioneuroma in the orbit were made...
  85. Tanaka M, Shibui S, Nomura K, Nakanishi Y. Pineal ganglioneuroblastoma in an adult. J Neurooncol. 1999;44:169-73 pubmed
    A 57-year-old male with pineal ganglioneuroblastoma was reported. The tumor was composed of a predominant ganglioneuromatous component and a small neuroblastic component. Primary ganglioneuroblastoma of the pineal region is extremely rare...
  86. Giannini G, Kim C, Di Marcotullio L, Manfioletti G, Cardinali B, Cerignoli F, et al. Expression of the HMGI(Y) gene products in human neuroblastic tumours correlates with differentiation status. Br J Cancer. 2000;83:1503-9 pubmed
  87. Hedborg F, Franklin G, Norrman J, Grimelius L, Wassberg E, Hero B, et al. Evidence of chromaffin oxygen sensing in neuroblastoma. Med Pediatr Oncol. 2001;36:149-53 pubmed
  88. Moukheiber A, Nicollas R, Roman S, Coze C, Triglia J. Primary pediatric neuroblastic tumors of the neck. Int J Pediatr Otorhinolaryngol. 2001;60:155-61 pubmed
    ..The histological diagnosis was ganglioneuroblastoma in three cases and neuroblastoma in one case...
  89. Slapa R, Jakubowski W, Kasperlik Zaluska A, Szopinski K, Debski R, Samsel M, et al. Adrenal ganglioneuroblastoma in pregnant woman: diagnosis with three-dimensional ultrasound. Eur Radiol. 2002;12 Suppl 3:S121-6 pubmed
    ..Three-dimensional colour Doppler and power Doppler studies showed ample neovascularization in the tumour and the adrenal vein draining to the inferior vena cava similarly to angiographic studies performed in the past...
  90. Wildhaber B, Niggli F, Stallmach T, Willi U, Stauffer U, Sacher P. Intestinal pseudoobstruction as a paraneoplastic syndrome in ganglioneuroblastoma. Eur J Pediatr Surg. 2002;12:429-31 pubmed
    Intestinal pseudoobstruction may be part of a paraneoplastic syndrome. We report a teenage girl with ganglioneuroblastoma who presented with severe constipation...
  91. Shimada H, Nakagawa A, Peters J, Wang H, Wakamatsu P, Lukens J, et al. TrkA expression in peripheral neuroblastic tumors: prognostic significance and biological relevance. Cancer. 2004;101:1873-81 pubmed
    This study was conducted to investigate the prognostic significance and biologic relevance of trkA expression levels in peripheral neuroblastic tumors (pNTs) (i.e., neuroblastoma, ganglioneuroblastoma, and ganglioneuroma).
  92. Darnill S, Gamage B. The patient's journey: palliative care--a parent's view. BMJ. 2006;332:1494-5 pubmed