acoustic neuroma


Summary: A benign SCHWANNOMA of the eighth cranial nerve (VESTIBULOCOCHLEAR NERVE), mostly arising from the vestibular branch (VESTIBULAR NERVE) during the fifth or sixth decade of life. Clinical manifestations include HEARING LOSS; HEADACHE; VERTIGO; TINNITUS; and FACIAL PAIN. Bilateral acoustic neuromas are associated with NEUROFIBROMATOSIS 2. (From Adams et al., Principles of Neurology, 6th ed, p673)

Top Publications

  1. Schlehofer B, Schlaefer K, Blettner M, Berg G, Bohler E, Hettinger I, et al. Environmental risk factors for sporadic acoustic neuroma (Interphone Study Group, Germany). Eur J Cancer. 2007;43:1741-7 pubmed
    The only known risk factor for sporadic acoustic neuroma is high-dose ionising radiation...
  2. Balasubramaniam A, Shannon P, Hodaie M, Laperriere N, Michaels H, Guha A. Glioblastoma multiforme after stereotactic radiotherapy for acoustic neuroma: case report and review of the literature. Neuro Oncol. 2007;9:447-53 pubmed
    ..of a patient who succumbed to a glioblastoma multiforme (GBM) after stereotactic radiotherapy for an acoustic neuroma (AN)...
  3. Hours M, Bernard M, Arslan M, Montestrucq L, Richardson L, Deltour I, et al. Can loud noise cause acoustic neuroma? Analysis of the INTERPHONE study in France. Occup Environ Med. 2009;66:480-6 pubmed publisher
    To investigate possible associations between risk of acoustic neuroma and exposure to loud noise in leisure and occupational settings.
  4. Hajioff D, Raut V, Walsh R, Bath A, Bance M, Guha A, et al. Conservative management of vestibular schwannomas: third review of a 10-year prospective study. Clin Otolaryngol. 2008;33:255-9 pubmed publisher
    ..Patients who failed conservative management had clinical outcomes that were not different from those who underwent primary treatment without a period of conservative management...
  5. Abram S, Rosenblatt P, Holcomb S. Stereotactic radiation techniques in the treatment of acoustic schwannomas. Otolaryngol Clin North Am. 2007;40:571-88, ix pubmed
  6. Myrseth E, Pedersen P, Møller P, Lund Johansen M. Treatment of vestibular schwannomas. Why, when and how?. Acta Neurochir (Wien). 2007;149:647-60; discussion 660 pubmed
    ..Furthermore, we review the literature concerning quality of life in patients with VS. Finally, we present our experience with a management strategy applied to more than 300 cases since 2001...
  7. Cafer S, Bayramoglu I, Uzum N, Yilmaz M, Memis L, Uygur K. Expression and clinical significance of Ki-67, oestrogen and progesterone receptors in acoustic neuroma. J Laryngol Otol. 2008;122:125-7 pubmed
    The objective was to assess the presence of Ki-67, and oestrogen and progesterone hormone receptors as well as their clinical correlates in acoustic neuroma.
  8. Vereeck L, Wuyts F, Truijen S, De Valck C, Van de Heyning P. The effect of early customized vestibular rehabilitation on balance after acoustic neuroma resection. Clin Rehabil. 2008;22:698-713 pubmed publisher
    To compare the effect of early customized vestibular rehabilitation with general instructions in patients after acoustic neuroma surgery.
  9. Schankin C, Gall C, Straube A. Headache syndromes after acoustic neuroma surgery and their implications for quality of life. Cephalalgia. 2009;29:760-71 pubmed publisher
    The patients of this prospective study were analysed for headache as a sequela of surgery for acoustic neuroma (AN)...

More Information


  1. Samkange Zeeb F, Schlehofer B, Schüz J, Schlaefer K, Berg Beckhoff G, Wahrendorf J, et al. Occupation and risk of glioma, meningioma and acoustic neuroma: results from a German case-control study (interphone study group, Germany). Cancer Epidemiol. 2010;34:55-61 pubmed publisher
    ..We investigated the association between six occupational categories defined a priori: chemical, metal, agricultural, construction, electrical/electronic and transport, and the risk of glioma, meningioma and acoustic neuroma.
  2. Ishiyama G, Lopez I, Beltran Parrazal L, Ishiyama A. Immunohistochemical localization and mRNA expression of aquaporins in the macula utriculi of patients with Meniere's disease and acoustic neuroma. Cell Tissue Res. 2010;340:407-19 pubmed publisher
    ..Vestibular maculae utriculi were acquired from patients undergoing surgery for Meniere's disease and acoustic neuroma and from autopsy (subjects with normal hearing and balance)...
  3. Zverina E. [Acoustic neuroma--vestibular schwannoma--personal experience of up-to-date management]. Cas Lek Cesk. 2010;149:269-76 pubmed
    b>Acoustic neuroma, properly called vestibular schwannoma, arises from the Schwann cells of the vestibular transitional zone of the vestibulocochlear nerve as the most frequent tumour of the posterior fossa. Its incidence is estimated at 1...
  4. Day A, Wang C, Chen C, Young Y. Correlating the cochleovestibular deficits with tumor size of acoustic neuroma. Acta Otolaryngol. 2008;128:756-60 pubmed publisher
    The tumor size of acoustic neuroma correlates with cochleovestibular deficits. Those tumors with global frequency hearing loss, bilateral gaze nystagmus, or absent caloric and VEMP responses may indicate a tumor size >2.5 cm.
  5. Rimaaja T, Haanpaa M, Blomstedt G, Farkkila M. Headaches after acoustic neuroma surgery. Cephalalgia. 2007;27:1128-35 pubmed
    Headache and depression were studied in patients who had undergone operation for acoustic neuroma. A questionnaire with headache and Beck Depression Inventory scale were sent to 228 patients, of whom 192 (84%) responded...
  6. Saito A, Morris C, Ito K, Watanabe F, Karasawa K, Mendenhall W, et al. Comparing size evaluation methods for acoustic neuroma after stereotactic radiosurgery. Radiat Med. 2007;25:339-45 pubmed
    b>Acoustic neuroma tumor size may be evaluated using several methods. Here we investigate the variations among measuring techniques.
  7. Myrseth E, Møller P, Pedersen P, Lund Johansen M. Vestibular schwannoma: surgery or gamma knife radiosurgery? A prospective, nonrandomized study. Neurosurgery. 2009;64:654-61; discussion 661-3 pubmed publisher
    ..To conduct a prospective, open, nonrandomized study of treatment-associated morbidity in patients undergoing microsurgery or gamma knife radiosurgery (GKRS) for vestibular schwannomas...
  8. Rajaraman P, Hutchinson A, Wichner S, Black P, Fine H, Loeffler J, et al. DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma. Neuro Oncol. 2010;12:37-48 pubmed publisher
    ..Altered DNA repair is also likely to affect the risk of meningioma and acoustic neuroma, but these tumors have not been well studied...
  9. Kano H, Kondziolka D, Khan A, Flickinger J, Lunsford L. Predictors of hearing preservation after stereotactic radiosurgery for acoustic neuroma. J Neurosurg. 2009;111:863-73 pubmed publisher
    ..The authors of this study evaluated tumor control and hearing preservation as they relate to tumor volume, imaging characteristics, and nerve and cochlear radiation dose following stereotactic radiosurgery (SRS) using the Gamma Knife...
  10. Gal T, Shinn J, Huang B. Current epidemiology and management trends in acoustic neuroma. Otolaryngol Head Neck Surg. 2010;142:677-81 pubmed publisher
    The objective of this study was to assess the epidemiology of acoustic neuroma and determine current trends in therapy using tumor registry techniques.
  11. Shaffer B, Cohen M, Bigelow D, Ruckenstein M. Validation of a disease-specific quality-of-life instrument for acoustic neuroma: the Penn Acoustic Neuroma Quality-of-Life Scale. Laryngoscope. 2010;120:1646-54 pubmed publisher
    To design and validate the first disease-specific quality-of-life instrument for acoustic neuroma, the Penn Acoustic Neuroma Quality-of-Life (PANQOL) scale.
  12. Cohen H, Bloomberg J. Modified dynamic visual acuity tests after acoustic neuroma resection. Acta Otolaryngol. 2007;127:825-8 pubmed
    ..These findings may have practical implications for seating design and design of tasks requiring good visual acuity while seated...
  13. Edwards C, Schwartzbaum J, Nise G, Forssén U, Ahlbom A, Lonn S, et al. Occupational noise exposure and risk of acoustic neuroma. Am J Epidemiol. 2007;166:1252-8 pubmed
    ..epidemiologic studies of occupational noise exposure based on self-report have suggested an association with acoustic neuroma. The goal of the present study was to further examine the association between noise exposure and acoustic ..
  14. Han Y, Kano H, Davis D, Niranjan A, Lunsford L. Cell phone use and acoustic neuroma: the need for standardized questionnaires and access to industry data. Surg Neurol. 2009;72:216-22; discussion 222 pubmed publisher be absorbed into the brain has prompted concerns that regular cell phone use may increase the risk of acoustic neuroma (AN) and other brain tumors...
  15. Douglas S, Yeung P, Daudia A, Gatehouse S, O Donoghue G. Spatial hearing disability after acoustic neuroma removal. Laryngoscope. 2007;117:1648-51 pubmed
    Previous studies on hearing loss (HL) after acoustic neuroma removal concentrate mainly on pure-tone hearing results rather than hearing disability...
  16. Stangerup S, Caye Thomasen P, Tos M, Thomsen J. Change in hearing during 'wait and scan' management of patients with vestibular schwannoma. J Laryngol Otol. 2008;122:673-81 pubmed
    ..To evaluate hearing changes during 'wait and scan' management of patients with vestibular schwannoma...
  17. Treleaven J, LowChoy N, Darnell R, Panizza B, Brown Rothwell D, Jull G. Comparison of sensorimotor disturbance between subjects with persistent whiplash-associated disorder and subjects with vestibular pathology associated with acoustic neuroma. Arch Phys Med Rehabil. 2008;89:522-30 pubmed publisher
    ..tests (cervical joint position error [JPE], neck-influenced eye movement control, postural stability) between subjects with persistent whiplash and subjects with unilateral vestibular pathology associated with acoustic neuroma.
  18. Fortnum H, O NEILL C, Taylor R, Lenthall R, Nikolopoulos T, Lightfoot G, et al. The role of magnetic resonance imaging in the identification of suspected acoustic neuroma: a systematic review of clinical and cost effectiveness and natural history. Health Technol Assess. 2009;13:iii-iv, ix-xi, 1-154 pubmed publisher
    ..a range of diagnostic strategies for investigating patients with unilateral hearing loss and/or tinnitus, with a view to confirming or eliminating a diagnosis of acoustic neuroma, and to describe the natural history of acoustic neuroma.
  19. Linskey M. Hearing preservation in vestibular schwannoma stereotactic radiosurgery: what really matters?. J Neurosurg. 2008;109 Suppl:129-36 pubmed publisher
    ..Serous otitis media, ossicular or temporal bone osteonecrosis, and chondromalacia are not likely to be relevant factors or considerations for hearing preservation after SRS...
  20. Schoemaker M, Swerdlow A, Ahlbom A, Auvinen A, Blaasaas K, Cardis E, et al. Mobile phone use and risk of acoustic neuroma: results of the Interphone case-control study in five North European countries. Br J Cancer. 2005;93:842-8 pubmed
    ..If such an effect exists, acoustic neuroma would be of particular concern because of the proximity of the acoustic nerve to the handset...
  21. Kanzaki J, Tos M, Sanna M, Moffat D, Monsell E, Berliner K. New and modified reporting systems from the consensus meeting on systems for reporting results in vestibular schwannoma. Otol Neurotol. 2003;24:642-8; discussion 648-9 pubmed
  22. Battaglia A, Mastrodimos B, Cueva R. Comparison of growth patterns of acoustic neuromas with and without radiosurgery. Otol Neurotol. 2006;27:705-12 pubmed
    To compare the natural history of acoustic neuroma growth to the reported growth rate of acoustic neuromas after radiosurgical therapy, a retrospective review and meta-analysis of the literature was performed...
  23. Schoemaker M, Swerdlow A, Auvinen A, Christensen H, Feychting M, Johansen C, et al. Medical history, cigarette smoking and risk of acoustic neuroma: an international case-control study. Int J Cancer. 2007;120:103-10 pubmed
    b>Acoustic neuroma (vestibular schwannoma) is a benign tumor of the vestibulocochlear nerve. Its recorded incidence is increasing but risk factors for this tumor have scarcely been investigated...
  24. Andersen H, Schrøder S, Bonding P. Unilateral deafness after acoustic neuroma surgery: subjective hearing handicap and the effect of the bone-anchored hearing aid. Otol Neurotol. 2006;27:809-14 pubmed
    To evaluate the subjective hearing handicap in patients with unilateral deafness after acoustic neuroma surgery and the effect of the Bone-anchored Hearing Aid (BAHA) on test band.
  25. Pollock B, Driscoll C, Foote R, Link M, Gorman D, Bauch C, et al. Patient outcomes after vestibular schwannoma management: a prospective comparison of microsurgical resection and stereotactic radiosurgery. Neurosurgery. 2006;59:77-85; discussion 77-85 pubmed
    ..Unless long-term follow-up evaluation shows frequent tumor progression at currently used radiation doses, radiosurgery should be considered the best management strategy for the majority of VS patients. ..
  26. Hardell L, Hansson Mild K, Sandström M, Carlberg M, Hallquist A, Påhlson A. Vestibular schwannoma, tinnitus and cellular telephones. Neuroepidemiology. 2003;22:124-9 pubmed
    ..For all other brain tumors taken together, the incidence significantly increased yearly by +0.80% (CI 0.59-1.02) for the time period 1960-1998, although the increase was only significant for benign tumors other than VS during 1960-1979. ..
  27. Myrseth E, Møller P, Pedersen P, Vassbotn F, Wentzel Larsen T, Lund Johansen M. Vestibular schwannomas: clinical results and quality of life after microsurgery or gamma knife radiosurgery. Neurosurgery. 2005;56:927-35; discussion 927-35 pubmed
    ..Some of the quality of life questions showed an association with facial nerve function and sex. Posttreatment facial nerve function, hearing, complication rates, and quality of life were all significantly in favor of GK radiosurgery. ..
  28. Evans D, Moran A, King A, Saeed S, Gurusinghe N, Ramsden R. Incidence of vestibular schwannoma and neurofibromatosis 2 in the North West of England over a 10-year period: higher incidence than previously thought. Otol Neurotol. 2005;26:93-7 pubmed
    ..To determine the incidence of vestibular schwannoma (VS) in sporadic, neurofibromatosis type 2 (NF2) germ-line and mosaic form in a 10-year period...
  29. Tufarelli D, Meli A, Alesii A, De Angelis E, Badaracco C, Falcioni M, et al. Quality of life after acoustic neuroma surgery. Otol Neurotol. 2006;27:403-9 pubmed
    The aim of this study is to assess patients' quality of life after acoustic neuroma surgery, and if some patients' characteristics, parameters of tumor and surgical parameters affect patients' quality of life. Retrospective study...
  30. Yamakami I, Uchino Y, Kobayashi E, Yamaura A. Conservative management, gamma-knife radiosurgery, and microsurgery for acoustic neurinomas: a systematic review of outcome and risk of three therapeutic options. Neurol Res. 2003;25:682-90 pubmed
    ..With a low rate of morbidity, GK radiosurgery suppresses tumor growth and provides good tumor control. Microsurgery provides the best tumor control, although mortality and morbidity are not completely eliminated. ..
  31. Pogodzinski M, Harner S, Link M. Patient choice in treatment of vestibular schwannoma. Otolaryngol Head Neck Surg. 2004;130:611-6 pubmed
    ..This is the first study to examine patient choice in treatment of vestibular schwannoma. ..
  32. Hardell L, Hansson Mild K. Mobile phone use and risk of acoustic neuroma: results of the interphone case-control study in five North European countries. Br J Cancer. 2006;94:1348-9; author reply 1352-3 pubmed
  33. Hasegawa T, Fujitani S, Katsumata S, Kida Y, Yoshimoto M, Koike J. Stereotactic radiosurgery for vestibular schwannomas: analysis of 317 patients followed more than 5 years. Neurosurgery. 2005;57:257-65; discussion 257-65 pubmed
    ..Good functional outcomes were observed in this group of patients. ..
  34. Sanna M, Taibah A, Russo A, Falcioni M, Agarwal M. Perioperative complications in acoustic neuroma (vestibular schwannoma) surgery. Otol Neurotol. 2004;25:379-86 pubmed
    Retrospective study and review of the complications other than those related to the facial nerve and hearing, encountered in acoustic neuroma surgery. Also, an evaluation of hospital stay and its relation with various factors.
  35. Scheller C, Strauss C, Fahlbusch R, Romstock J. Delayed facial nerve paresis following acoustic neuroma resection and postoperative vasoactive treatment. Zentralbl Neurochir. 2004;65:103-7 pubmed
    Delayed facial nerve paresis is a well known clinical phenomenon following acoustic neuroma surgery, typically occurring early during the postoperative course...
  36. Hardell L, Carlberg M, Hansson Mild K. Case-control study on cellular and cordless telephones and the risk for acoustic neuroma or meningioma in patients diagnosed 2000-2003. Neuroepidemiology. 2005;25:120-8 pubmed
    ..results for benign brain tumors with data from 413 cases (89% response rate), 305 with meningioma, 84 with acoustic neuroma, 24 with other types and 692 controls (84% response rate)...
  37. Iwai Y, Yamanaka K, Shiotani M, Uyama T. Radiosurgery for acoustic neuromas: results of low-dose treatment. Neurosurgery. 2003;53:282-87; discussion 287-8 pubmed
    ..The results of radiosurgical treatment of acoustic neuromas have improved by reducing the tumor marginal doses. We report relatively long-term follow-up results (>5 yr) for patients who underwent low-dose radiosurgery...
  38. Chang S, Gibbs I, Sakamoto G, Lee E, Oyelese A, Adler J. Staged stereotactic irradiation for acoustic neuroma. Neurosurgery. 2005;56:1254-61; discussion 1261-3 pubmed
    ..Sunnyvale, CA) image-guided radiosurgery now makes it more practical to treat acoustic neuroma with a staged approach...
  39. Boisson Bertrand D, Laxenaire M, Mertes P. Recovery after prolonged anaesthesia for acoustic neuroma surgery: desflurane versus isoflurane. Anaesth Intensive Care. 2006;34:338-42 pubmed
    In this study, 33 patients were randomly assigned to receive desflurane (D) or isoflurane (I) for acoustic neuroma surgery...
  40. Del Rio L, Lassaletta L, Alfonso C, Sarriá M, Gavilan J. [Clinical tumoral size dissociation in acoustic neuroma: reality or measure distortion?]. Acta Otorrinolaringol Esp. 2006;57:345-9 pubmed
    In this study we have analyzed (i) the audiometric frequencies more often affected in acoustic neuroma (AN), (ii) the percentage of patients presenting normal hearing and those with sudden hearing loss, (iii) if there is a correlation ..
  41. Muscat J, Malkin M, Shore R, Thompson S, Neugut A, Stellman S, et al. Handheld cellular telephones and risk of acoustic neuroma. Neurology. 2002;58:1304-6 pubmed
    The hypothesis that intracranial energy deposition from handheld cellular telephones causes acoustic neuroma was tested in an epidemiologic study of 90 patients and 86 control subjects. The relative risk was 0.9 (p = 0...
  42. Wiet R, Mamikoglu B, Odom L, Hoistad D. Long-term results of the first 500 cases of acoustic neuroma surgery. Otolaryngol Head Neck Surg. 2001;124:645-51 pubmed
    This retrospective study focuses on 2 outcome results after surgical intervention for acoustic neuroma: (1) facial nerve status, and (2) hearing preservation.
  43. Chee G, Nedzelski J, Rowed D. Acoustic neuroma surgery: the results of long-term hearing preservation. Otol Neurotol. 2003;24:672-6 pubmed
    To report the long-term outcome hearing results following acoustic neuroma surgery. To determine whether changes, if any, in the thresholds of the operated ear are mirrored in the contralateral unoperated side...
  44. Tanaka Y, Hongo K, Tada T, Kobayashi S. What is the best method for reporting tumor diameter in vestibular schwannoma?. Neurosurgery. 2003;53:634-7; discussion 637-8 pubmed
    ..To clarify the most appropriate method to represent the tumor volume, tumor diameters according to various measuring methods were statistically compared with the actual tumor volume...
  45. Rajaraman P, De Roos A, Stewart P, Linet M, Fine H, Shapiro W, et al. Occupation and risk of meningioma and acoustic neuroma in the United States. Am J Ind Med. 2004;45:395-407 pubmed
    Workplace exposures may be related to the development of brain tumors. In this case-control study, we examine occupation as a risk factor for meningioma and acoustic neuroma.
  46. Ishikawa K, Wang Y, Wong W, Shibata Y, Itasaka Y. Gait instability in patients with acoustic neuroma. Acta Otolaryngol. 2004;124:486-9 pubmed
    To investigate pathological gait in patients with unilateral acoustic neuroma using tactile sensors placed under both feet.
  47. Raut V, Walsh R, Bath A, Bance M, Guha A, Tator C, et al. Conservative management of vestibular schwannomas - second review of a prospective longitudinal study. Clin Otolaryngol Allied Sci. 2004;29:505-14 pubmed
    ..Tumours in this study confined to the IAC typically demonstrated minimal or no growth on serial MRI scanning. Regular follow-up with interval scanning is mandatory in all patients...
  48. Hardell L, Mild K, Carlberg M. Further aspects on cellular and cordless telephones and brain tumours. Int J Oncol. 2003;22:399-407 pubmed
    ..11, 95% CI=1.01-1.22, and cordless phones OR=1.09, 95% CI=1.01-1.19. There was a tendency of a shorter tumour induction period for ipsilateral exposure to microwaves than for contralateral, which may indicate a tumour promotor effect...
  49. Becker S, Jackler R, Pitts L. Cerebrospinal fluid leak after acoustic neuroma surgery: a comparison of the translabyrinthine, middle fossa, and retrosigmoid approaches. Otol Neurotol. 2003;24:107-12 pubmed
    To determine whether the choice of surgical approach affects the rate of postoperative cerebrospinal fluid leakage in patients who have undergone surgical resection of acoustic neuroma.
  50. DiMaio S, Mohr G, Dufour J, Albrecht S. Distal mycotic aneurysm of the AICA mimicking intracanalicular acoustic neuroma. Can J Neurol Sci. 2003;30:388-92 pubmed
    ..We report a distal fusiform mycotic pseudoaneurysm of the anterior inferior cerebellar artery (AICA) that simulated an acoustic neuroma on presentation.
  51. Christensen H, Schüz J, Kosteljanetz M, Poulsen H, Thomsen J, Johansen C. Cellular telephone use and risk of acoustic neuroma. Am J Epidemiol. 2004;159:277-83 pubmed, the authors examined the possible association between use of cellular telephones and development of acoustic neuroma. Between 2000 and 2002, they ascertained 106 incident cases and matched these persons with 212 randomly ..
  52. Lonn S, Ahlbom A, Hall P, Feychting M. Mobile phone use and the risk of acoustic neuroma. Epidemiology. 2004;15:653-9 pubmed
    Radiofrequency exposure from mobile phones is concentrated to the tissue closest to the handset, which includes the auditory nerve. If this type of exposure increases tumor risk, acoustic neuroma would be a potential concern.
  53. Ryzenman J, Pensak M, Tew J. Headache: a quality of life analysis in a cohort of 1,657 patients undergoing acoustic neuroma surgery, results from the acoustic neuroma association. Laryngoscope. 2005;115:703-11 pubmed
    On the basis of survey results of the Acoustic Neuroma Association (ANA), we report patient ratings of postoperative headache (POH) symptoms, determine its effect on quality of life (QOL), and review the literature regarding POH after ..
  54. Paek S, Chung H, Jeong S, Park C, Kim C, Kim J, et al. Hearing preservation after gamma knife stereotactic radiosurgery of vestibular schwannoma. Cancer. 2005;104:580-90 pubmed
  55. Propp J, McCarthy B, Davis F, Preston Martin S. Descriptive epidemiology of vestibular schwannomas. Neuro Oncol. 2006;8:1-11 pubmed
    ..While improvements in diagnosis and reporting may explain some of these trends, further consideration of potential etiologic factors may be warranted...
  56. Hartsell T, Long D, Kirsch J. The efficacy of postoperative ondansetron (Zofran) orally disintegrating tablets for preventing nausea and vomiting after acoustic neuroma surgery. Anesth Analg. 2005;101:1492-6 pubmed
    ..and vomiting in a prospective, randomized, placebo-controlled double-blind trial of 60 patients undergoing acoustic neuroma resection. Each patient received intraoperative ondansetron (4 mg IV) or placebo 30 min before case end...
  57. Lee D, Maseyesva B, Westra W, Long D, Niparko J, Califano J. Microsatellite analysis of recurrent vestibular schwannoma (acoustic neuroma) following stereotactic radiosurgery. Otol Neurotol. 2006;27:213-9 pubmed
    ..Genetic and immunohistochemical studies may provide insight into the mechanisms of vestibular schwannoma (VS) recurrence following radiation therapy...
  58. Stangerup S, Caye Thomasen P, Tos M, Thomsen J. The natural history of vestibular schwannoma. Otol Neurotol. 2006;27:547-52 pubmed
    ..As treatment may depend on tumor growth, there is a demand of a treatment strategy based on hard data on the growth pattern of these tumors. This article reports growth data registered prospectively in 552 patients...
  59. Nageris B, Popovtzer A. Acoustic neuroma in patients with completely resolved sudden hearing loss. Ann Otol Rhinol Laryngol. 2003;112:395-7 pubmed
    ..The aim of the present clinical study was to determine whether acoustic neuroma-induced hearing loss may be associated with full recovery...
  60. Ahsan S, Telischi F, Hodges A, Balkany T. Cochlear implantation concurrent with translabyrinthine acoustic neuroma resection. Laryngoscope. 2003;113:472-4 pubmed
    ..Auditory rehabilitation in these patients can be challenging. We present the case of one such patient who underwent a concurrent translabyrinthine vestibular schwannoma resection and cochlear implantation in the same ear...
  61. Caye Thomasen P, Hansen S, Dethloff T, Stangerup S, Thomsen J. Sublocalization and volumetric growth pattern of intracanalicular vestibular schwannomas. Laryngoscope. 2006;116:1131-5 pubmed
    ..None of several previous reports on the growth pattern of vestibular schwannomas (VS) have dealt with the sublocalization and volumetric growth pattern of intracanalicular tumors. This paper reports such data from 196 patients...
  62. Doherty J, Friedman R. Controversies in building a management algorithm for vestibular schwannomas. Curr Opin Otolaryngol Head Neck Surg. 2006;14:305-13 pubmed
    ..The present review examines the various mainstream treatment options, benefits and risks, and controversies involved in developing a management algorithm for treatment of vestibular schwannoma...
  63. Quaranta A, Gandolfi A, Fava G, Quaranta N, Zini C. Paradoxical effects of contralateral white noise on evoked otoacoustic emissions in ears with acoustic neuroma. Acta Otolaryngol. 2000;120:227-30 pubmed
    ..loss, while it is absent or reduced in ears to which the vestibular nerve has been cut and in ears with acoustic neuroma (AN)...
  64. Chopra R, Kondziolka D, Niranjan A, Lunsford L, Flickinger J. Long-term follow-up of acoustic schwannoma radiosurgery with marginal tumor doses of 12 to 13 Gy. Int J Radiat Oncol Biol Phys. 2007;68:845-51 pubmed
    ..To define long-term tumor control and clinical outcomes of radiosurgery with marginal tumor doses of 12 to 13 Gy for unilateral acoustic schwannoma...
  65. Cross J, Baguley D, Antoun N, Moffat D, Prevost A. Reproducibility of volume measurements of vestibular schwannomas - a preliminary study. Clin Otolaryngol. 2006;31:123-9 pubmed
    ..A preliminary study to investigate the intra-observer and inter-observer variability of measurements of vestibular schwannoma volume using an area-tracing and linear dimension measurement method...
  66. Nikolopoulos T, O Donoghue G. Acoustic neuroma management: an evidence-based medicine approach. Otol Neurotol. 2002;23:534-41 pubmed
    Partisan claims supporting the use of microsurgical resection, radiologic surveillance, and radiosurgery in acoustic neuroma management appear widely in the published literature...
  67. Luppino F, Grooters E, de Bruine F, Zwinderman A, van der Mey A. Volumetrical measurements in vestibular schwannoma, the influence of slice thickness and patient's repositioning. Otol Neurotol. 2006;27:962-8 pubmed
    ..The second objective was to evaluate the influence of the use of different magnetic resonance imaging (MRI) slice thickness and the influence of patient's repositioning on the measurements' outcome...