melanotic neuroectodermal tumor

Summary

Summary: A benign, rapidly growing, deeply pigmented tumor of the jaw and occasionally of other sites, consisting of an infiltrating mass of cells arranged in an alveolar pattern, and occurring almost exclusively in infants. Its source of origin is in dispute, the various theories giving rise to its several names. (Dorland, 27th ed)

Top Publications

  1. Selim H, Shaheen S, Barakat K, Selim A. Melanotic neuroectodermal tumor of infancy: review of literature and case report. J Pediatr Surg. 2008;43:E25-9 pubmed publisher
    b>Melanotic neuroectodermal tumor of infancy (MNTI) is an uncommon, fast-growing, pigmented neoplasm of neural crest origin. It primarily affects the maxilla of the infants during the first year of life...
  2. Woessmann W, Neugebauer M, Gossen R, Blütters Sawatzki R, Reiter A. Successful chemotherapy for melanotic neuroectodermal tumor of infancy in a baby. Med Pediatr Oncol. 2003;40:198-9 pubmed
  3. Metwaly H, Cheng J, Maruyama S, Ohshiro K, Suzuki I, Hoshina Y, et al. Establishment and characterization of new cell lines derived from melanotic neuroectodermal tumor of infancy arising in the mandible. Pathol Int. 2005;55:331-42 pubmed
    Three cell systems (MINT1/2/3) derived from a melanotic neuroectodermal tumor of infancy (MNTI) arising in the mandible of a 1-month-old newborn boy have been established, and their cytological natures have been characterized...
  4. Barrett A, Morgan M, Ramsay A, Farthing P, Newman L, Speight P. A clinicopathologic and immunohistochemical analysis of melanotic neuroectodermal tumor of infancy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;93:688-98 pubmed
    The purpose of this study was to review the features of 8 cases of melanotic neuroectodermal tumor of infancy (MNTI) of the jaws with respect to the expression of NB84, CD99, PGP 9...
  5. Matsumoto M, Sakuma J, Suzuki K, Kawakami M, Sasaki T, Kodama N. Melanotic neuroectodermal tumor of infancy in the skull: case report and review of the literature. Surg Neurol. 2005;63:275-80 pubmed
    b>Melanotic neuroectodermal tumor of infancy (MNTI) is a rare neoplasm that develops during the first year of life and grows rapidly. Early diagnosis and radical surgery are critical for a long-term cure...
  6. George J, Edwards M, Jakacki R, Kho Duffin J. Melanotic neuroectodermal tumor of infancy. AJNR Am J Neuroradiol. 1995;16:1273-5 pubmed
    We present a case of malignant melanotic neuroectodermal tumor of infancy arising in the skull and secondarily invading brain...
  7. Tan O, Atik B, Ugras S. Melanotic neuroectodermal tumor in a newborn. Int J Pediatr Otorhinolaryngol. 2005;69:1441-4 pubmed
    b>Melanotic neuroectodermal tumor of infancy (MNTI) is an uncommon, fast-growing, pigmented neoplasm of neural crest origin; it primarily affects the maxilla of the infants during the first year of life...
  8. Eckardt A, Swennen G, Teltzrow T. Melanotic neuroectodermal tumor of infancy involving the mandible: 7-year follow-up after hemimandibulectomy and costochondral graft reconstruction. J Craniofac Surg. 2001;12:349-54 pubmed
    ..We report a case of a 6-months old female infant suffering from a melanotic neuroectodermal tumor of infancy involving the mandible...
  9. Hoshina Y, Hamamoto Y, Suzuki I, Nakajima T, Ida Yonemochi H, Saku T. Melanotic neuroectodermal tumor of infancy in the mandible: report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;89:594-9 pubmed
    A case of melanotic neuroectodermal tumor of infancy occurring in the mandible is described. The patient was a 1-month-old boy with a rapidly growing tumor of the mandible...

More Information

Publications99

  1. Khoddami M, Squire J, Zielenska M, Thorner P. Melanotic neuroectodermal tumor of infancy: a molecular genetic study. Pediatr Dev Pathol. 1998;1:295-9 pubmed
    b>Melanotic neuroectodermal tumor of infancy is a rare but well-recognized entity in pediatric pathology...
  2. Mast B, Kapadia S, Yunis E, Bentz M. Subtotal maxillectomy for melanotic neuroectodermal tumor of infancy. Plast Reconstr Surg. 1999;103:1961-3 pubmed
    b>Melanotic neuroectodermal tumor of infancy is a rare pigmented neoplasm occurring in infants before 1 year of age. It is a rapidly growing tumor that most frequently affects the craniofacial skeleton...
  3. El Saggan A, Bang G, Olofsson J. Melanotic neuroectodermal tumour of infancy arising in the maxilla. J Laryngol Otol. 1998;112:61-4 pubmed
    ..The genital organs are the most frequent extracranial site. We present two cases of melanotic neuroectodermal tumour of infancy arising in the maxilla...
  4. Gaiger de Oliveira M, Thompson L, Chaves A, Rados P, da Silva Lauxen I, Filho M. Management of melanotic neuroectodermal tumor of infancy. Ann Diagn Pathol. 2004;8:207-12 pubmed
    b>Melanotic neuroectodermal tumor of infancy is a rare congenital neoplasm involving the head and neck in young patients...
  5. Kruse Losler B, Gaertner C, Burger H, Seper L, Joos U, Kleinheinz J. Melanotic neuroectodermal tumor of infancy: systematic review of the literature and presentation of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102:204-16 pubmed
    b>Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, distinctive neoplasm of early infancy with rapid expansile growth and a high rate of recurrences...
  6. Suzuki C, Maeda M, Matsushima N, Takamura M, Matsubara T, Taki W, et al. Melanotic neuroectodermal tumor of infancy in the skull: CT and MRI features. J Neuroradiol. 2007;34:212-3 pubmed
  7. Kaya S, Unal O, Sarac S, Gedikoglu G. Melanotic neuroectodermal tumor of infancy: report of two cases and review of literature. Int J Pediatr Otorhinolaryngol. 2000;52:169-72 pubmed
    b>Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, distinctive neoplasm containing melanin; it primarily affects the maxilla of the infants during the first year of life...
  8. Bouckaert M, Raubenheimer E. Gigantiform melanotic neuroectodermal tumor of infancy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;86:569-72 pubmed
    b>Melanotic neuroectodermal tumor of infancy is a rare neoplasm of possibly neural crest origin, and it predominantly occurs in the premaxillas of infants less than 12 months old...
  9. Calabrese F, Danieli D, Valente M. Melanotic neuroectodermal tumor of the epididymis in infancy: case report and review of the literature. Urology. 1995;46:415-8 pubmed
    b>Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, benign tumor that usually involves the upper or lower jaw, but it may also arise in other sites. We describe a case of MNTI located in the left epididymis of a 6-month-old boy...
  10. Anil S, Raji M, Beeana V. Melanotic neuroectodermal tumor of infancy. Report of a case. Indian J Dent Res. 1993;4:65-7 pubmed
    A case of melanotic neuroectodermal tumor of infancy involving the right maxillary alveolar ridge region of a 4 month old girl is reported. Clinical, histopathological and laboratory findings supported the diagnosis...
  11. Chaudhary A, Wakhlu A, Mittal N, Misra S, Mehrotra D, Wakhlu A. Melanotic neuroectodermal tumor of infancy: 2 decades of clinical experience with 18 patients. J Oral Maxillofac Surg. 2009;67:47-51 pubmed publisher
    The purpose of this article is to report our experience in the management of 18 patients with melanotic neuroectodermal tumor of infancy involving the maxillary alveolus.
  12. Neven J, Hulsbergen van der Kaa C, Groot Loonen J, de Wilde P, Merkx M. Recurrent melanotic neuroectodermal tumor of infancy: a proposal for treatment protocol with surgery and adjuvant chemotherapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106:493-6 pubmed publisher
    ..a 4-month-old male infant treated with combined surgery and chemotherapy for an aggressive recurrent melanotic neuroectodermal tumor of infancy (MNTI) on the top of the alveolar process of the mandible with a long-term follow-up is ..
  13. Hoshino S, Takahashi H, Shimura T, Nakazawa S, Naito Z, Asano G. Melanotic neuroectodermal tumor of infancy in the skull associated with high serum levels of catecholamine. Case report. J Neurosurg. 1994;80:919-24 pubmed
    The case of a 5-month-old boy with a left retromastoid melanotic neuroectodermal tumor of infancy is presented. The tumor extended from the subcutaneous tissue of the occiput to the cerebellar hemisphere...
  14. Fowler D, Chisholm J, Roebuck D, Newman L, Malone M, Sebire N. Melanotic neuroectodermal tumor of infancy: clinical, radiological, and pathological features. Fetal Pediatr Pathol. 2006;25:59-72 pubmed
    We present a case of a 4-month-old female infant with a maxillary melanotic neuroectodermal tumor of infancy (MNTI) and review the pooled data from previous publications on this entity...
  15. Carnevale G, Mortelliti A. The operating microscope in the management of melanotic neuroectodermal tumor of infancy. Am J Otolaryngol. 2001;22:76-9 pubmed
    b>Melanotic neuroectodermal tumor of infancy is a rare condition that is most commonly found within the head and neck regions. We present a 4-month-old boy with a melanotic neuroectodermal tumor of infancy of his maxilla...
  16. Dilu N, Bobe A, Sokolo M. [Melanotic progonoma. Apropos of a voluminous tumor in an infant]. Rev Stomatol Chir Maxillofac. 1998;99:103-5 pubmed
    ..The large size of the tumor can hinder feeding in infants. Surgical cure is generally easy and outcome quite satisfactory without recurrence. ..
  17. Higashi K, Ogawa T, Onuma M, Usubuchi H, Imai Y, Takata I, et al. Clinicopathological features of melanotic neuroectodermal tumor of infancy: Report of two cases. Auris Nasus Larynx. 2016;43:451-4 pubmed publisher
    b>Melanotic neuroectodermal tumor of infancy (MNTI) is an extremely rare, pigmented neoplastic entity of neural crest origin...
  18. Badenhorst P, Voas M, Rebay I, Wu C. Biological functions of the ISWI chromatin remodeling complex NURF. Genes Dev. 2002;16:3186-98 pubmed
    ..Finally, mutants in NURF subunits exhibit neoplastic transformation of larval blood cells that causes melanotic tumors to form. ..
  19. Kumari T, Venugopal M, Mathews A, Kusumakumary P. Effectiveness of chemotherapy in melanotic neurectodermal tumor of infancy. Pediatr Hematol Oncol. 2005;22:199-206 pubmed
    ..All 3 infants showed good response to chemotherapy. In 2 of them complete residual tumor resection became possible; 2 of them are alive and tumor regression continues. One child had local recurrence later and was lost for follow-up. ..
  20. Miękus N, Kowalski P, Olędzka I, Plenis A, Bień E, Miękus A, et al. Cyclodextrin-modified MEKC method for quantification of selected acidic metabolites of catecholamines in the presence of various biogenic amines. Application to diagnosis of neuroblastoma. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;1003:27-34 pubmed publisher
    ..applied to evaluate the levels of selected acidic metabolites of catecholamines like HVA, VMA and DOPAC in urine samples collected from patients diagnosed with neuroblastoma (NB), melanotic neuroectodermal tumor of infancy (MNTI).
  21. McGuire T, Gomes P, Forte V, Sandor G. Rapidly growing intraoral swelling involving the maxilla of an infant. J Oral Maxillofac Surg. 2007;65:1595-9 pubmed
  22. Slootweg P. Lesions of the jaws. Histopathology. 2009;54:401-18 pubmed publisher
    ..Other lesions, not strictly odontogenic but also mainly confined to the jaw bones, are giant cell lesions, fibro-osseous lesions, and the melanotic neuro-ectodermal tumour of infancy. They also will be included in this overview...
  23. Liu H, Chen T, Chang H. Melanotic neuroectodermal tumour of infancy in the maxilla: a case report. Int J Paediatr Dent. 2004;14:371-5 pubmed
    ..There have only been a limited number of reports on the dental rehabilitation of postoperative MNTI. We report a case of maxillary MNTI in which the need for dental rehabilitation was emphasized. ..
  24. Moreau A, Galmiche L, Belhous K, Franchi G, Couloigner V, Nevoux J, et al. Prenatal Diagnosis of a Melanotic Neuroectodermal Tumor of Infancy (MNTI): A Case Report With a Favorable Outcome After Chemotherapy Failure and Incomplete Resection. J Pediatr Hematol Oncol. 2017;: pubmed publisher
    ..Surgical biopsy confirmed a melanotic neuroectodermal tumor of infancy...
  25. Gomes C, Diniz M, de Menezes G, Castro W, Gomez R. BRAFV600E Mutation in Melanotic Neuroectodermal Tumor of Infancy: Toward Personalized Medicine?. Pediatrics. 2015;136:e267-9 pubmed publisher
    The melanotic neuroectodermal tumor of infancy (MNTI) is a rare neoplasm that primarily affects the maxilla of infants during their first year of life...
  26. Kobayashi T, Kunimi K, Imao T, Ohkawa M, Komatsu K, Mizukami Y, et al. Melanotic neuroectodermal tumor of infancy in the epididymis. Case report and literature review. Urol Int. 1996;57:262-5 pubmed
    We report a case of melanotic neuroectodermal tumor that originated in the right epididymis of a 4-month-old Japanese male and review reports of similar cases...
  27. Lambropoulos V, Neofytou A, Sfougaris D, Mouravas V, Petropoulos A. Melanotic neuroectodermal tumor of infancy (MNT1) arising in the skull. Short review of two cases. Acta Neurochir (Wien). 2010;152:869-75 pubmed publisher
    b>Melanotic neuroectodermal tumor of infancy (MNT1) is a rare congenital pigmented neoplasm of neural crest origin, locally aggressive, and rapidly growing that develops during the first year of life...
  28. Toda T, Sadi A, Kiyuna M, Egawa H, Tamamoto T, Toyoda Z. Pigmented neuroectodermal tumor of infancy in the epididymis. A case report. Acta Cytol. 1998;42:775-80 pubmed
    ..Cytology has not been applied to the diagnoses of PNTI. In our opinion, fine needle aspiration cytology could be helpful in the preoperative diagnosis of this tumor. ..
  29. Henley J, Ferry J, Ulbright T. Miscellaneous rare paratesticular tumors. Semin Diagn Pathol. 2000;17:319-39 pubmed
    ..the ovarian-type epithelial tumors (OTET), the desmoplastic small round cell tumor (DSRCT), and the melanotic neuroectodermal tumor of infancy (MNTI)...
  30. Rege J, Shet T, Sawant H, Naik L. Cytologic diagnosis of a melanotic neuroectodermal tumor of infancy occurring in the cranial bones. Diagn Cytopathol. 1999;21:280-3 pubmed
    ..In the present case, following the cytologic diagnosis a wide local excision was carried out, and the histologic examination confirmed the cytologic diagnosis. Diagn. Cytopathol. 1999;21:280-283. ..
  31. de Souza P, Merly F, Maia D, Castro W, Gomez R. Cell cycle-associated proteins in melanotic neuroectodermal tumor of infancy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;88:466-8 pubmed
    ..expression of cell cycle-associated proteins in neuroblastic and melanocytic cell populations of melanotic neuroectodermal tumor of infancy. Three cases of melanotic neuroectodermal tumor of infancy were selected...
  32. Eckardt A, Swennen G, Brachvogel P. [Autologous rib graft for restoration of continuity defects of the mandible]. Mund Kiefer Gesichtschir. 2005;9:66-70 pubmed
    ..Histological diagnoses were melanotic neuroectodermal tumor and hemangioendothelioma of the mandible...
  33. Rickert C, Probst Cousin S, Blasius S, Gullotta F. Melanotic progonoma of the brain: a case report and review. Childs Nerv Syst. 1998;14:389-93 pubmed
    ..We present the case of a 1-year-old boy suffering from a melanotic progonoma of the pineal gland, who died at the age of 22 months with extensive spinal and abdominal metastases 10 months after partial removal of the tumor. ..
  34. Kanungo A, Chandi S. Melanotic neuroectodermal tumor of the epididymis. A case report. Indian J Cancer. 1994;31:138-40 pubmed
    ..Melanotic neuroectodermal tumors occur very rarely in the epididymis, only eleven cases having been reported to date in the world literature. An additional case is reported which we believe is the first from India. ..
  35. Freitag S, Eagle R, Shields J, Duker J, Font R. Melanogenic neuroectodermal tumor of the retina (primary malignant melanoma of the retina). Arch Ophthalmol. 1997;115:1581-4 pubmed
    ..To our knowledge, such an ocular tumor has not been reported previously. ..
  36. Gupta R, Howell R, Amin M. Paratesticular paraganglioma: a rare cause of an intrascrotal mass. Arch Pathol Lab Med. 2009;133:811-3 pubmed publisher
    ..Herein the relevant histopathologic differential diagnoses are discussed along with a brief review of literature. ..
  37. Paueksakon P, Parker J, Fan X, Miles G, Ruiz H, Wushensky C, et al. Melanotic neuroectodermal tumor of infancy discovered after head trauma. Pediatr Neurosurg. 2002;36:33-6 pubmed
    b>Melanotic neuroectodermal tumor of infancy (MNTI) is a rare neoplasm that generally arises in the maxilla during the first year of life. Involvement of bones of the cranial vault or brain is extremely rare...
  38. Eckardt A, Swennen G, Barth E, Brachvogel P. Long-term results after mandibular continuity resection in infancy: the role of autogenous rib grafts for mandibular restoration. J Craniofac Surg. 2006;17:255-60 pubmed
    ..Histologic diagnoses were melanotic neuroectodermal tumor, hemangioendothelioma of the mandible, and ameloblastoma...
  39. Chossegros C, Cheynet F, Gentet J, Scheiner C. [Melanotic neuroectodermal tumor in an infant]. Arch Pediatr. 1995;2:545-7 pubmed
    b>Melanotic neuroectodermal tumor is a mostly benign tumor, rare in childhood, essentially located in the head and neck region. A two-month-old girl was seen for a rapidly increasing odontogenic tumor which appeared cystic at the CT scan...
  40. Jeon H, Kong D, Shin H. Melanotic neuroectodermal tumor of infancy: a case report. Childs Nerv Syst. 2008;24:1489-92 pubmed publisher
    b>Melanotic neuroectodermal tumor of infancy (MNTI) is a rare pigmented tumor generally occurring in the head and neck region in children 12 months of age or younger...
  41. Foster K, Choudhri A, Lingo R, Boop F. Melanotic Neuroectodermal Tumor of Infancy with Involvement of the Superior Sagittal Sinus. Pediatr Neurosurg. 2017;52:36-40 pubmed
    b>Melanotic neuroectodermal tumor of infancy (MNTI) is a rare lesion that typically manifests in the first year of life, most commonly involving the facial bones...
  42. Al Marzooq Y, Al Bagshi M, Chopra R, Hashish H. Melanotic neuroectodermal tumor of infancy in the soft tissues of the arm: fine needle aspiration biopsy and histologic correlation-a case report. Diagn Cytopathol. 2003;29:352-5 pubmed
    A case of melanotic neuroectodermal tumor of infancy (MNTI) presenting as a soft tissue mass in the right arm of a 6-mo female child is discussed...
  43. Galera Ruiz H, Gomez Angel D, Vazquez Ramirez F, Sanguino Fabre J, Salazar Fernandez C, Gonzalez Hachero J. Fine needle aspiration in the pre-operative diagnosis of melanotic neuroectodermal tumour of infancy. J Laryngol Otol. 1999;113:581-4 pubmed
    ..This tumour belongs to a field of pathology with which many otolaryngologists may not be familiar. ..
  44. Moreau A, Galmiche L, Minard Colin V, Rachwalski M, Belhous K, Orbach D, et al. Melanotic neuroectodermal tumor of infancy (MNTI) of the head and neck: A French multicenter study. J Craniomaxillofac Surg. 2018;46:201-206 pubmed publisher
    b>Melanotic neuroectodermal tumor of infancy (MNTI) of the head and neck is a rare entity with uncertain clinical behavior...
  45. Kirigin M, Dzombeta T, Seiwerth S, Mesić M, Stepan Giljevic J, Kruslin B. Melanotic Neuroectodermal Tumor of Infancy of the Upper Arm: A Case Report. Med Princ Pract. 2017;: pubmed publisher
    To present a case of a 6-month-old infant with melanotic neuroectodermal tumor of infancy (MNTI) in the upper arm.
  46. Irving R, Parikh A, Coumbe A, Albert D. Melanotic neuroectodermal tumour of infancy. J Laryngol Otol. 1993;107:1045-8 pubmed
    ..This tumour, which many otolaryngologists may not be familiar with, should be included in the differential diagnosis of head and neck neoplasms in infants and young children. ..
  47. Desai S, Roy S, Borges A. Recurrent melanotic neuroectodermal tumour of infancy of the epididymis and testis: a case report. Indian J Pathol Microbiol. 2005;48:363-4 pubmed
    b>Melanotic neuroectodermal tumor of infancy or melanotic progonoma is an uncommon tumor, presenting in infants. The epididymis and testis are rare sites of occurrence. This tumor can be confused with round cell tumor (RCT)...
  48. Barnes D, Hookway E, Athanasou N, Kashima T, Oppermann U, Hughes S, et al. A germline mutation of CDKN2A and a novel RPLP1-C19MC fusion detected in a rare melanotic neuroectodermal tumor of infancy: a case report. BMC Cancer. 2016;16:629 pubmed publisher
    b>Melanotic neuroectodermal tumor of infancy (MNTI) is exceptionally rare and occurs predominantly in the head and neck (92.8 % cases)...
  49. JAIN P, Garg R, Kapoor A. Melanotic neuroectodermal tumor of infancy in oral cavity at unusual age. Fetal Pediatr Pathol. 2010;29:344-52 pubmed publisher
    The melanotic neuroectodermal tumor of infancy is an extremely rare, fast-growing but benign lesion, commonly occurring in the maxilla of children within the first year of life...
  50. Popa C, Stelea C, Popa R, Popescu E. [Oral and perioral endogenous pigmented lesions]. Rev Med Chir Soc Med Nat Iasi. 2008;112:1054-60 pubmed
    ..In this article, pigmented lesions are described to allow practitioner to elaborate a positive diagnosis of endogenous pigmented lesions and to facilitate an early detection of these lesions particularly the malignant ones...
  51. Ünsal H, Yalcin M. Melanotic Neuroectodermal Tumor of Infancy in the Maxilla. J Craniofac Surg. 2018;29:e28-e30 pubmed publisher
    b>Melanotic neuroectodermal tumor of infancy is uncommon and has rapid expansile growth...
  52. Piperi E, Rake S, Tosios K, Vasilopoulou E, Rake A, Sandler N, et al. Mandibular melanotic neuroectodermal tumor of infancy treated conservatively with enucleation. J Craniofac Surg. 2010;21:685-8 pubmed publisher
    b>Melanotic neuroectodermal tumor of infancy (MNTI) is an uncommon, rapidly growing neoplasm of neural crest origin that primarily develops in the maxilla of infants during their first year of life...
  53. Nakanishi K, Hori H, Matsubara T, Matsuda K, Deguchi T, Komada Y. Recurrent melanotic neuroectodermal tumor in the orbit successfully treated with resection followed by pediculated periosteal flaps. Pediatr Blood Cancer. 2008;51:430-2 pubmed publisher
    b>Melanotic neuroectodermal tumor of infancy (MNTI) is a rare tumor arising mainly in the orofacial bones. Among more than 200 cases described in articles, only seven cases involved orbital regions...
  54. Hered R, Smithwick W, Sandler E, Goldstein J. Orbital melanotic neuroectodermal tumor of infancy successfully treated with chemotherapy and subtotal excision. J AAPOS. 2007;11:504-5 pubmed
    b>Melanotic neuroectodermal tumor of infancy is a rare condition that typically presents within the first 6 months of life. It rarely metastasizes but is locally aggressive...
  55. Pantanowitz L, Galan A, Gang D, Crisi G, LaPolice P, Goulart R. Diagnostic cytologic features of an epididymal melanotic neuroectodermal tumor of infancy present in scrotal fluid: a case report. Acta Cytol. 2006;50:460-5 pubmed
    The cytologic features of melanotic neuroectodermal tumor of infancy (MNTI) have been described in rare cases only, and these reports have been based solely on direct smears obtained from aspirated tumor material or from touch ..
  56. Rustemeyer J, Thieme V, Loeschke S, Bremerich A, Kössling F. [Melanotic neuroectodermal tumor of infancy]. Klin Padiatr. 2001;213:69-73 pubmed
    The melanotic neuroectodermal tumor of infancy is a rare and so far as being classified neoplasm with a high rate of recurrence for one year after diagnosis...
  57. Gomez R, Carvalho Silva E, Castro W. Melanotic neuroectodermal tumor of infancy: report of a case. J Clin Pediatr Dent. 1996;20:253-5 pubmed
    The melanotic neuroectodermal tumor of infancy (MNTI) is an uncommon benign neoplasm frequently detected in young infants, which has a predilection for the head and neck region, particularly maxilla...
  58. Dashti S, Cohen M, Cohen A. Role of radical surgery for intracranial melanotic neuroectodermal tumor of infancy: case report. Neurosurgery. 1999;45:175-8 pubmed
    b>Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, locally aggressive tumor that arises most commonly from the maxilla or mandible...
  59. Sorrentino G, Monsurro M, Pettinato G, Vanni R, Zuddas A, di Porzio U, et al. Establishment and characterization of a human neuroectodermal cell line (TB) from a cerebrospinal fluid specimen. Brain Res. 1999;827:205-9 pubmed
    ..In summary, TB cells represent primitive neuroectodermal cells having the potential for neuronal, myoblastic and possibly melanoblastic differentiation...
  60. Belajouza H, Slama A, Moatemri R, Bouzaiene M, Belghith M, Nouri A, et al. [Unusual tumor in a 3 month-old baby]. Rev Stomatol Chir Maxillofac. 2007;108:243-4 pubmed
  61. Raila F, Parent A, Ward B, Fratkin J. Three-dimensional reconstruction of melanotic neuroectodermal tumor of infancy involving the occipital bone and dura. J Neuroimaging. 1997;7:123-6 pubmed
    A rare case of melanotic neuroectodermal tumor of infancy involving the right occipital bone in an 11-month-old infant is described. The bone tumor and its dural extension were surgically removed...
  62. Kumar Dutta H. Jaw and gum tumours in children. Pediatr Surg Int. 2009;25:781-4 pubmed publisher
    ..Children presenting with jaw tumours during 2001 till 2007 are presented. Their modes of presentation, operative procedures and findings, histology and post operative results have been described...
  63. Dammann O, Hagel C, Allers B, Grubel G, Schulte F. Malignant melanotic neuroectodermal tumor of infancy. Childs Nerv Syst. 1995;11:186-8 pubmed
    A 2-month-old boy underwent surgery for removal of a right temporal melanotic neuroectodermal tumor of infancy (MNTI). Histologically the tumor tissue showed signs of malignancy...
  64. Olaya J, Raghavan R, Totaro L, Zouros A. Pineal anlage tumor in a 5-month-old boy. J Neurosurg Pediatr. 2010;5:636-40 pubmed publisher
  65. Burov V, Dmitrieva N, Rudenko O. Nonlinear ultrasound: breakdown of microscopic biological structures and nonthermal impact on a malignant tumor. Dokl Biochem Biophys. 2002;383:101-4 pubmed
  66. Nelson Z, Newman L, Loukota R, Williams D. Melanotic neuroectodermal tumour of infancy: an immunohistochemical and ultrastructural study. Br J Oral Maxillofac Surg. 1995;33:375-80 pubmed
    ..Both cases have responded to local excision, with no recurrence more than a year after initial treatment...
  67. Haider N, Mc Dermott M, Fitzgerald R. Melanotic neuroectodermal tumour of infancy arising in skull. Med Pediatr Oncol. 2003;41:495-6 pubmed
  68. Kantar M, Sezak M, Turhan T, Kitis O, Mutluer S, Demirag B, et al. Melanotic progonoma of the skull in infancy. Childs Nerv Syst. 2008;24:1371-5 pubmed publisher
    Melanotic progonoma or melanotic neuroectodermal tumor is a rare tumor in infancy. This lesion has to be considered in the differential diagnosis of benign or malignant lesions of calvarium.
  69. Nitta T, Endo T, Tsunoda A, Kadota Y, Matsumoto T, Sato K. Melanotic neuroectodermal tumor of infancy: a molecular approach to diagnosis. Case report. J Neurosurg. 1995;83:145-8 pubmed
    A case of melanotic neuroectodermal tumor of infancy arising from the transverse sinus is presented. The tumor was located on the outer surface of the dura and extended extracranially through the occipitomastoid suture...
  70. Shuangshoti S, Mujananon S, Bunyaratavej K, Chaipipat M, Khaoroptham S. A 4-year-old girl with mass in the frontotemporal bone. Brain Pathol. 2006;16:333-4 pubmed
  71. Gorhan C, Soto Ares G, Ruchoux M, Blond S, Pruvo J. Melanotic neuroectodermal tumour of the pineal region. Neuroradiology. 2001;43:944-7 pubmed
    ..The pathological diagnosis was made on the resected piece. Embryology of the pineal gland and the histology of melanotic neuroectodermal tumour of infancy are discussed...
  72. Hafsa C, Golli M, Kriaa S, Zbidi M, Bouzaiene M, Belguith M, et al. [Radiological quiz of the month: a maxillary mass in an infant]. Arch Pediatr. 2005;12:52, 67-9 pubmed
  73. Patankar T, Prasad S, Goel A, Perumpillichira J, Desai A. Malignant melanotic neuroectodermal tumour of infancy affecting the occipital squama. J Postgrad Med. 1998;44:73-5 pubmed
    ..An unusual case of a melanotic neuroectodermal tumour of the occipital squama, which underwent malignant transformation in a nine-month-old infant is reported and pertinent literature reviewed...
  74. Latham K, Podda S, Wolfe S. Melanocytic neuroectodermal tumor of infancy: excision and primary palatal repair at 7 months of age. J Craniofac Surg. 2007;18:450-4 pubmed
    ..A 7-month-old boy was found in a Haitian orphanage with a growing, very large mass originating from his right maxilla...
  75. Di Rocco F, Roujeau T, Puget S, Peyre M, Zerah M. Slow-growing lambdoid melanotic neuroectodermal tumor of infancy. Eur J Pediatr. 2007;166:739-41 pubmed
    ..To illustrate this latter presentation, we present a case of a slowly growing melanotic neuroectodermal tumor of infancy located on the right lambdoid suture.
  76. Shaia W, DiNardo L, Underhill T, Cesca C. Recurrent melanotic neuroectodermal tumor of infancy. Am J Otolaryngol. 2002;23:249-52 pubmed
  77. Omodaka S, Saito R, Kumabe T, Kawagishi J, Jokura H, Sonoda Y, et al. Melanotic neuroectodermal tumor of the brain recurring 12 years after complete remission: case report. Brain Tumor Pathol. 2010;27:51-7 pubmed publisher
    We describe a rare case of melanotic neuroectodermal tumor (MNT) of the brain recurring 12 years after complete remission. An 11-year-old girl initially presented with exotropia and bilateral papilledema...
  78. Tantcheu V, Ben Romdhane M, Ducou Le Pointe H, Montagne J. [Melanotic progonoma]. J Radiol. 2002;83:63-5 pubmed
  79. Demirci A, Kawamura Y, Sze G, Duncan C. MR of parenchymal neurocutaneous melanosis. AJNR Am J Neuroradiol. 1995;16:603-6 pubmed
    ..Two cases of neurocutaneous melanosis are presented. MR showed hyperintense areas in the brain on short-repetition-time/short-echo-time sequences, compatible with intraparenchymal melanin deposits. No leptomeningeal abnormality was seen...
  80. Poe L, Roitberg D, Galyon D. Neurocutaneous melanosis presenting as an intradural mass of the cervical canal: magnetic resonance features and the presence of melanin as a clue to diagnosis: case report. Neurosurgery. 1994;35:741-3 pubmed
    ..An imaging clue to the diagnosis was apparent as T1-weighted shortening on magnetic resonance in the pia and/or cortex of the cerebellar folia, suggesting the presence of melanin...
  81. Oruckaptan H, Soylemezoglu F, Kutluk T, Akalan N. Benign melanocytic tumor in infancy: discussion on a rare case and review of the literature. Pediatr Neurosurg. 2000;32:240-7 pubmed
    ..The prognostic criteria, differential diagnosis and its embryological aspects are discussed with an extensive review of the related existing literature...
  82. Adad S, Pinheiro S, Marinho E, Reis M, Rua A, Rodrigues D. Melanotic neuroectodermal tumor of infancy (MNTI). Diagn Cytopathol. 2004;30:67-9 pubmed
  83. Gupta A, Trehan A, Marwaha R, Sharma R, Nijhawan R. Melanotic neuroectodermal tumour in an infant. Indian J Pediatr. 2002;69:725-6 pubmed
    ..The encounter with an unusual melanotic neuroectodermal tumour of the jaw in a young infant is described in this report. There has been no recurrence, after complete surgical excision, in a follow-up period of six months...
  84. Jurincic Winkler C, Metz K, Klippel K. Melanotic neuroectodermal tumor of infancy (MNTI) in the epididymis. A case report with immunohistological studies and special consideration of malignant features. Zentralbl Pathol. 1994;140:181-5 pubmed
    ..The small tumor cells were only slightly positive for GFAP, NKI-C3, NSE, and S100 but they were negative for cytokeratin and vimentin. Neurofilament and chromogranin could not be proved in the tumor...
  85. Antunes A, Freitas R, Oliveira P, Rebouças R. Melanotic neuroectodermal tumor of infancy: case report. Arq Neuropsiquiatr. 2005;63:670-2 pubmed
    b>Melanotic neuroectodermal tumor of infancy (MNTI) is a rare tumor, locally aggressive, usually originated from maxilla and mandible and rarely from the skull...
  86. Deminiere C, Akele Akpo M, Rivel J, Vergnes P. [Epididymal tumor in a six-months-old infant]. Ann Pathol. 2002;22:52-5 pubmed
    ..Immunohistochemistry staining and electron microscopy led to the diagnosis of mealnotic neuroectodermal tumor, or progonoma. Prognosis of progonoma, a benign tumor, is generally good, but malignant transformation has been reported...
  87. Berns S, Pearl G. Review of pineal anlage tumor with divergent histology. Arch Pathol Lab Med. 2006;130:1233-5 pubmed
    ..We review the literature on this tumor, including the clinical presentation, gross pathology, histopathology, immunohistochemistry, differential diagnosis, and prognosis...
  88. Elli M, Aydin O, Pinarli F, Dagdemir A, Dabak N, Selcuk M, et al. Melanotic neuroectodermal tumor of infancy of the femur. Pediatr Hematol Oncol. 2006;23:579-86 pubmed
    b>Melanotic neuroectodermal tumor of infancy (MNTI) is a rare neoplasm that often occurs during the first year of life. More than 90% of MNTIs occur in the head and neck region, with most on the anterior part of the maxillary ridge...
  89. Melino G, Draoui M, Bernardini S, Bellincampi L, Reichert U, Cohen P. Regulation by retinoic acid of insulin-degrading enzyme and of a related endoprotease in human neuroblastoma cell lines. Cell Growth Differ. 1996;7:787-96 pubmed
    ..These results provide evidence that complex posttranslational molecular mechanisms participate in the autocrine/paracrine growth control of the IGF-II loop in neuroblastomas involving proteolytic systems...
  90. Min K. Usefulness of electron microscopy in the diagnosis of "small" round cell tumors of the sinonasal region. Ultrastruct Pathol. 1995;19:347-63 pubmed
    ..in 27 cases: esthesioneuroblastoma (EN), 12; undifferentiated carcinoma, 6; melanoma, 3; lymphoma, 3; melanotic neuroectodermal tumor, 1; rhabdomyosarcoma, 1; and pituitary adenoma, 1...