craniopharyngioma

Summary

Summary: A benign pituitary-region neoplasm that originates from Rathke's pouch. The two major histologic and clinical subtypes are adamantinous (or classical) craniopharyngioma and papillary craniopharyngioma. The adamantinous form presents in children and adolescents as an expanding cystic lesion in the pituitary region. The cystic cavity is filled with a black viscous substance and histologically the tumor is composed of adamantinomatous epithelium and areas of calcification and necrosis. Papillary craniopharyngiomas occur in adults, and histologically feature a squamous epithelium with papillations. (From Joynt, Clinical Neurology, 1998, Ch14, p50)

Top Publications

  1. Kiehna E, Merchant T. Radiation therapy for pediatric craniopharyngioma. Neurosurg Focus. 2010;28:E10 pubmed publisher
    The treatment of craniopharyngioma is highly controversial. Continued advances in limited surgery and radiation therapy have maintained excellent local disease control while minimizing treatment-related sequelae...
  2. Aquilina K, Merchant T, Rodriguez Galindo C, Ellison D, Sanford R, Boop F. Malignant transformation of irradiated craniopharyngioma in children: report of 2 cases. J Neurosurg Pediatr. 2010;5:155-61 pubmed publisher
    Malignant transformation of craniopharyngioma is a rare event; only 3 cases have been reported in children, all in the Japanese literature. The authors describe 2 additional pediatric cases...
  3. Moshkin O, Scheithauer B, Syro L, Velasquez A, Horvath E, Kovacs K. Collision tumors of the sella: craniopharyngioma and silent pituitary adenoma subtype 3: case report. Endocr Pathol. 2009;20:50-5 pubmed publisher
    ..The association of a craniopharyngioma and a pituitary adenoma is rare...
  4. Hölsken A, Gebhardt M, Buchfelder M, Fahlbusch R, Blumcke I, Buslei R. EGFR signaling regulates tumor cell migration in craniopharyngiomas. Clin Cancer Res. 2011;17:4367-77 pubmed publisher
    ..Targeting the EGFR signaling pathway by gefitinib may present a promising pharmacologic option in the treatment of this challenging tumor disease. ..
  5. Kołtowska Häggström M, Geffner M, Jonsson P, Monson J, Abs R, Hana V, et al. Discontinuation of growth hormone (GH) treatment during the transition phase is an important factor determining the phenotype of young adults with nonidiopathic childhood-onset GH deficiency. J Clin Endocrinol Metab. 2010;95:2646-54 pubmed publisher
    ..Little is known about the impact of childhood-onset GH deficiency (GHD), in particular the duration of GH cessation during the transition phase, on adult phenotype...
  6. Zhao R, Deng J, Liang X, Zeng J, Chen X, Wang J. Treatment of cystic craniopharyngioma with phosphorus-32 intracavitary irradiation. Childs Nerv Syst. 2010;26:669-74 pubmed publisher
    ..The aim of the study was to evaluate the effect of phosphorus-32 colloid ([(32)P]) intracavitary irradiation on the treatment of patients with cystic craniopharyngiomas...
  7. Roth C, Blevins J, Ralston M, Elfers C, Ogimoto K, Kaiyala K, et al. A novel rodent model that mimics the metabolic sequelae of obese craniopharyngioma patients. Pediatr Res. 2011;69:230-6 pubmed publisher
    Patients with craniopharyngioma (CP), a tumor located in the pituitary and/or hypothalamus, are susceptible to developing obesity and many metabolic complications...
  8. Andoniadou C, Gaston Massuet C, Reddy R, Schneider R, Blasco M, Le Tissier P, et al. Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma. Acta Neuropathol. 2012;124:259-71 pubmed publisher
    Activating mutations in the gene encoding ?-catenin have been identified in the paediatric form of human craniopharyngioma (adamantinomatous craniopharyngioma, ACP), a histologically benign but aggressive pituitary tumour accounting for ..
  9. Burghaus S, Hölsken A, Buchfelder M, Fahlbusch R, Riederer B, Hans V, et al. A tumor-specific cellular environment at the brain invasion border of adamantinomatous craniopharyngiomas. Virchows Arch. 2010;456:287-300 pubmed publisher
    ..Whether this facilitates the characteristic infiltrative growth pattern or is the consequence of an activated Wnt signaling pathway, detectable in 90% of these tumors, will need further consideration. ..

More Information

Publications71

  1. Minniti G, Esposito V, Amichetti M, Enrici R. The role of fractionated radiotherapy and radiosurgery in the management of patients with craniopharyngioma. Neurosurg Rev. 2009;32:125-32; discussion 132 pubmed publisher
    ..Longer follow-up is necessary to confirm the excellent tumor control and the potential reduction of long-term radiation toxicity...
  2. Pettorini B, Inzitari R, Massimi L, Tamburrini G, Caldarelli M, Fanali C, et al. The role of inflammation in the genesis of the cystic component of craniopharyngiomas. Childs Nerv Syst. 2010;26:1779-84 pubmed publisher
    b>Craniopharyngioma accounts for 5-10% of childhood tumors and, despite of the benign histological features, its clinical course can be malignant because of critical anatomical relationships with neural and vascular structures and the ..
  3. Guo C, Wang Y, Zhou Z, Zhu J, Li Z, Guo C. [Curative effect of stereotactic 186Re endocavitary irradiation on cystic craniopharyngioma]. Zhonghua Zhong Liu Za Zhi. 2010;32:548-50 pubmed
    To evaluate the treatment results of stereotactic (186)Re intracavitary irradiation in the patients with craniopharyngioma.
  4. Niranjan A, Kano H, Mathieu D, Kondziolka D, Flickinger J, Lunsford L. Radiosurgery for craniopharyngioma. Int J Radiat Oncol Biol Phys. 2010;78:64-71 pubmed publisher
    ..To analyze the outcomes of gamma knife stereotactic radiosurgery (SRS) for residual or recurrent craniopharyngiomas and evaluate the factors that optimized the tumor control rates...
  5. Elliott R, Moshel Y, Wisoff J. Minimal residual calcification and recurrence after gross-total resection of craniopharyngioma in children. J Neurosurg Pediatr. 2009;3:276-83 pubmed publisher
    The purpose of this study was to assess the impact of minimal residual calcification without enhancing tumor on the rate of recurrence after gross-total resection (GTR) of craniopharyngioma in children.
  6. Liu J, Christiano L, Patel S, Eloy J. Surgical nuances for removal of retrochiasmatic craniopharyngioma via the endoscopic endonasal extended transsphenoidal transplanum transtuberculum approach. Neurosurg Focus. 2011;30:E14 pubmed publisher
    ..An illustrative intraoperative video demonstrating the technique is also presented...
  7. Hashizume C, Mori Y, Kobayashi T, Shibamoto Y, Nagai A, Hayashi N. Stereotactic radiotherapy using Novalis for craniopharyngioma adjacent to optic pathways. J Neurooncol. 2010;98:239-47 pubmed publisher
    b>Craniopharyngioma has benign histological character...
  8. Campbell P, McGettigan B, Luginbuhl A, Yadla S, Rosen M, Evans J. Endocrinological and ophthalmological consequences of an initial endonasal endoscopic approach for resection of craniopharyngiomas. Neurosurg Focus. 2010;28:E8 pubmed publisher
    ..The expanded endoscopic approach to craniopharyngiomas has recently been described in several small case series. The authors present their experience with this technique and review the available literature...
  9. Simoneau Roy J, O Gorman C, Pencharz P, Adeli K, Daneman D, Hamilton J. Insulin sensitivity and secretion in children and adolescents with hypothalamic obesity following treatment for craniopharyngioma. Clin Endocrinol (Oxf). 2010;72:364-70 pubmed publisher
    b>Craniopharyngioma (CP), a tumour occurring in the hypothalamic-pituitary area, results in morbid obesity in 25-60% of affected children...
  10. Xia Z, Liu W, Li S, Jia G, Zhang Y, Li C, et al. Expression of matrix metalloproteinase-9, type IV collagen and vascular endothelial growth factor in adamantinous craniopharyngioma. Neurochem Res. 2011;36:2346-51 pubmed publisher
    ..9 (MMP-9), type IV collagen (Col IV) and vascular endothelial growth factor (VEGF) in adamantinomatous craniopharyngioma (ACP) and analyze the correlation between the level of these markers and adamantimous craniopharyngiomas ..
  11. Rajput D, Srivastva A, Kumar R, Mahapatra A. Recurrent chemical meningitis in craniopharyngioma without reduction in size of cyst: case report of two cases and review of the literature. Turk Neurosurg. 2012;22:233-6 pubmed publisher
    Chemical meningitis is a rare phenomenon due to rupture of a craniopharyngioma cyst; it develops because of presence of cholesterol crystals in cyst fluid secreted by the squamous epithelium lining of the cyst...
  12. Manley P, McKendrick K, McGillicudy M, Chi S, Kieran M, Cohen L, et al. Sleep dysfunction in long term survivors of craniopharyngioma. J Neurooncol. 2012;108:543-9 pubmed publisher
    ..We conducted a retrospective review of all patients with craniopharyngioma more than 2 years off treatment and who were evaluated in the neuro-oncology survivorship clinic between ..
  13. Masson Côté L, Masucci G, Atenafu E, Millar B, Cusimano M, Croul S, et al. Long-term outcomes for adult craniopharyngioma following radiation therapy. Acta Oncol. 2013;52:153-8 pubmed publisher
    We report long-term outcomes in adult patients with craniopharyngioma following surgery and radiation therapy (RT).
  14. Ondruch A, Maryniak A, Kropiwnicki T, Roszkowski M, Daszkiewicz P. Cognitive and social functioning in children and adolescents after the removal of craniopharyngioma. Childs Nerv Syst. 2011;27:391-7 pubmed publisher
    The aim of this study is to assess cognitive, emotional and social functioning in children and adolescents after the removal of craniopharyngioma.
  15. Hammond J, Hall S. Functional analysis and treatment of aggressive behavior following resection of a craniopharyngioma. Dev Med Child Neurol. 2011;53:369-74 pubmed publisher
    b>Craniopharyngioma is a relatively rare, benign tumor that most often affects pre-adolescent children...
  16. Nielsen E, Feldt Rasmussen U, Poulsgaard L, Kristensen L, Astrup J, Jørgensen J, et al. Incidence of craniopharyngioma in Denmark (n = 189) and estimated world incidence of craniopharyngioma in children and adults. J Neurooncol. 2011;104:755-63 pubmed publisher
    We studied the incidence of craniopharyngioma in Denmark during the period 1985-2004 and estimated worldwide incidence rates (IR) of craniopharyngioma based on a literature review...
  17. Honegger J, Tatagiba M. Craniopharyngioma surgery. Pituitary. 2008;11:361-73 pubmed publisher
    ..The contemporary neurosurgical strategy of treating craniopharyngiomas with early and late outcome data is presented. Neurosurgical therapy is only beneficial in the context of an interdisciplinary treatment concept as discussed here...
  18. Cohen M, Bartels U, Branson H, Kulkarni A, Hamilton J. Trends in treatment and outcomes of pediatric craniopharyngioma, 1975-2011. Neuro Oncol. 2013;15:767-74 pubmed publisher
    b>Craniopharyngioma tumors and their treatment can lead to significant long-term morbidity due to their proximity to vital structures. The optimal treatment has been debated for many years...
  19. Jane J, Prevedello D, Alden T, Laws E. The transsphenoidal resection of pediatric craniopharyngiomas: a case series. J Neurosurg Pediatr. 2010;5:49-60 pubmed publisher
    ..The purpose of this study is to report the outcomes after transsphenoidal surgery in a consecutive series of pediatric patients with craniopharyngiomas treated at a single institution with the goal of gross-total resection (GTR)...
  20. Muller H. Childhood craniopharyngioma: current controversies on management in diagnostics, treatment and follow-up. Expert Rev Neurother. 2010;10:515-24 pubmed publisher
    ..The treatment of craniopharyngioma remains controversial...
  21. Kim R, Shah R, Tershakovec A, Zemel B, Sutton L, Grimberg A, et al. Energy expenditure in obesity associated with craniopharyngioma. Childs Nerv Syst. 2010;26:913-7 pubmed publisher
    Obesity is a common yet incompletely understood complication of childhood craniopharyngioma. We hypothesized that craniopharyngioma is associated with specific defects in energy balance compared to obese control children.
  22. Joo J, Rigo J, Sapi Z, Timár B. Foetal craniopharyngioma diagnosed by prenatal ultrasonography and confirmed by histopathological examination. Prenat Diagn. 2009;29:160-3 pubmed publisher
    b>Craniopharyngioma is an intracranial tumour, which usually develops in children and young adults and rarely occurs in intrauterine life.
  23. Liubinas S, Munshey A, Kaye A. Management of recurrent craniopharyngioma. J Clin Neurosci. 2011;18:451-7 pubmed publisher
    b>Craniopharyngioma accounts for approximately 1.2% to 4.6% of all intracranial tumours...
  24. Iughetti L, Bruzzi P. Obesity and craniopharyngioma. Ital J Pediatr. 2011;37:38 pubmed publisher
    ..One of these subgroups comprises patients treated for childhood cancers and namely survivors of craniopharyngioma. The high incidence of obesity in this group makes these patients an important disease model to better ..
  25. Crom D, Smith D, Xiong Z, Onar A, Hudson M, Merchant T, et al. Health status in long-term survivors of pediatric craniopharyngiomas. J Neurosci Nurs. 2010;42:323-8; quiz 329-30 pubmed
    ..The purpose of this study was to analyze the health status of long-term survivors of pediatric craniopharyngioma treated primarily with radiation and conservative surgical resection...
  26. Jane J, Kiehna E, Payne S, Early S, Laws E. Early outcomes of endoscopic transsphenoidal surgery for adult craniopharyngiomas. Neurosurg Focus. 2010;28:E9 pubmed publisher
    ..The purpose of this study was to report the outcomes of the endoscopic transsphenoidal approach for adults with craniopharyngiomas in whom the goal was gross-total resection...
  27. Roderick E, Karavitaki N, Wass J. Craniopharyngiomas. Historical aspects of their management. Hormones (Athens). 2008;7:271-4 pubmed
  28. Muller H. Childhood craniopharyngioma--current concepts in diagnosis, therapy and follow-up. Nat Rev Endocrinol. 2010;6:609-18 pubmed publisher
    ..5-2.0 new cases per million of the population per year, and ?30-50% of all cases represent childhood craniopharyngioma. These partly cystic embryogenic malformations of the sellar region are presumably derived from Rathke cleft ..
  29. Muller H. Consequences of craniopharyngioma surgery in children. J Clin Endocrinol Metab. 2011;96:1981-91 pubmed publisher
    Childhood craniopharyngioma, a rare embryogenic tumorous malformation of the sellar region, is characterized by survival rates ranging from 91 to 98%...
  30. Garcia Lavandeira M, Saez C, Diaz Rodriguez E, Perez Romero S, Senra A, Dieguez C, et al. Craniopharyngiomas express embryonic stem cell markers (SOX2, OCT4, KLF4, and SOX9) as pituitary stem cells but do not coexpress RET/GFRA3 receptors. J Clin Endocrinol Metab. 2012;97:E80-7 pubmed publisher
    ..Recently, stem/progenitor cells in the rodent and human pituitary have been characterized as expressing GFRA2/RET, PROP1, and stem cell markers such as SOX2 and OCT4 (GPS cells)...
  31. Holmer H, Ekman B, Bjork J, Nordstöm C, Popovic V, Siversson A, et al. Hypothalamic involvement predicts cardiovascular risk in adults with childhood onset craniopharyngioma on long-term GH therapy. Eur J Endocrinol. 2009;161:671-9 pubmed publisher
    b>Craniopharyngioma patients without GH therapy are at an increased cardiovascular disease (CVD) risk and particularly concerning women...
  32. Holmer H, Pozarek G, Wirfalt E, Popovic V, Ekman B, Bjork J, et al. Reduced energy expenditure and impaired feeding-related signals but not high energy intake reinforces hypothalamic obesity in adults with childhood onset craniopharyngioma. J Clin Endocrinol Metab. 2010;95:5395-402 pubmed publisher
    Obesity is a frequent manifestation of hypothalamic damage from a craniopharyngioma (CP). It is not yet clarified whether the obesity is due to alterations in energy expenditure, i.e...
  33. Zada G, Lin N, Ojerholm E, Ramkissoon S, Laws E. Craniopharyngioma and other cystic epithelial lesions of the sellar region: a review of clinical, imaging, and histopathological relationships. Neurosurg Focus. 2010;28:E4 pubmed publisher
    ..The authors review the developmental relationships and differentiating features of various epithelial lesions of the sellar region...
  34. Steinbok P, Hukin J. Intracystic treatments for craniopharyngioma. Neurosurg Focus. 2010;28:E13 pubmed publisher
    b>Craniopharyngioma is a benign tumor histopathologically and in theory should be curable by radical resection...
  35. Pettorini B, Tamburrini G, Massimi L, Caldarelli M, Di Rocco C. Endoscopic transventricular positioning of intracystic catheter for treatment of craniopharyngioma. Technical note. J Neurosurg Pediatr. 2009;4:245-8 pubmed publisher
    The intracystic injection of chemo- and radiotherapeutic agents was introduced for the treatment of craniopharyngioma to control tumor growth and to delay the potentially harmful effects of surgery or radiation therapy...
  36. Iwata H, Tatewaki K, Inoue M, Yokota N, Baba Y, Nomura R, et al. Single and hypofractionated stereotactic radiotherapy with CyberKnife for craniopharyngioma. J Neurooncol. 2012;106:571-7 pubmed publisher
    ..the clinical outcome of single and hypofractionated stereotactic radiotherapy (SRT) with CyberKnife for craniopharyngioma. Forty-three patients (21 men and 22 women; median age 44 years; range 3-85 years) were treated at two ..
  37. Sherlock M, Ayuk J, Tomlinson J, Toogood A, Aragon Alonso A, Sheppard M, et al. Mortality in patients with pituitary disease. Endocr Rev. 2010;31:301-42 pubmed publisher
    ..b>Craniopharyngioma patients have a particularly increased risk of mortality as a result of the tumor itself and treatment to ..
  38. Yang I, Sughrue M, Rutkowski M, Kaur R, Ivan M, Aranda D, et al. Craniopharyngioma: a comparison of tumor control with various treatment strategies. Neurosurg Focus. 2010;28:E5 pubmed publisher
    ..Here, the authors summarize the published literature regarding rates of tumor control with various treatment modalities for craniopharyngiomas...
  39. Elliott R, Moshel Y, Wisoff J. Surgical treatment of ectopic recurrence of craniopharyngioma. Report of 4 cases. J Neurosurg Pediatr. 2009;4:105-12 pubmed publisher
    Local recurrence following radical resection is one of the most common complications of pediatric craniopharyngioma. Only 28 cases of ectopic recurrence of craniopharyngioma have been reported in the literature, and only 13 cases ..
  40. Kobayashi T. Long-term results of gamma knife radiosurgery for 100 consecutive cases of craniopharyngioma and a treatment strategy. Prog Neurol Surg. 2009;22:63-76 pubmed publisher
    ..is proposed, based on evaluation of long-term results of gamma knife radiosurgery for residual or recurrent craniopharyngioma after microsurgery. A total of 98 of 107 patients were followed up for a mean of 65...
  41. Hölsken A, Buchfelder M, Fahlbusch R, Blumcke I, Buslei R. Tumour cell migration in adamantinomatous craniopharyngiomas is promoted by activated Wnt-signalling. Acta Neuropathol. 2010;119:631-9 pubmed publisher
    ..This suggests that activated Wnt-signalling serves as a promoter of the epithelial migration machinery by regulating target molecules such as fascin in adaCP tumour cells...
  42. Laffond C, Dellatolas G, Alapetite C, Puget S, Grill J, Habrand J, et al. Quality-of-life, mood and executive functioning after childhood craniopharyngioma treated with surgery and proton beam therapy. Brain Inj. 2012;26:270-81 pubmed publisher
    Childhood craniopharyngioma, a benign tumour with a good survival rate, is associated with important neurocognitive and psychological morbidity, reducing quality-of-life (QoL).
  43. Gaston Massuet C, Andoniadou C, Signore M, Jayakody S, Charolidi N, Kyeyune R, et al. Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans. Proc Natl Acad Sci U S A. 2011;108:11482-7 pubmed publisher
    ..those that survive weaning develop lethal pituitary tumors, which closely resemble human adamantinomatous craniopharyngioma, an epithelial tumor associated with mutations in the human ?-catenin gene...
  44. Vinchon M, Weill J, Delestret I, Dhellemmes P. Craniopharyngioma and hypothalamic obesity in children. Childs Nerv Syst. 2009;25:347-52 pubmed publisher
    Obesity is a major concern in children treated for craniopharyngioma and is caused by hypothalamic damage. The role of aggressive surgical removal has been questioned, leading some authors to recommend a minimalist approach...
  45. Winkfield K, Linsenmeier C, Yock T, Grant P, Yeap B, Butler W, et al. Surveillance of craniopharyngioma cyst growth in children treated with proton radiotherapy. Int J Radiat Oncol Biol Phys. 2009;73:716-21 pubmed publisher
    ..The aim of this study was to report our experience with cyst enlargement during conformal proton RT for children with craniopharyngioma and to make recommendations regarding mid-treatment surveillance.
  46. Holmer H, Popovic V, Ekman B, Follin C, Siversson A, Erfurth E. Hypothalamic involvement and insufficient sex steroid supplementation are associated with low bone mineral density in women with childhood onset craniopharyngioma. Eur J Endocrinol. 2011;165:25-31 pubmed publisher
    Data on bone mineral density (BMD) are lacking in adults with childhood onset (CO)-craniopharyngioma (CP) with hypothalamic damage from the tumor. In patients with CO GH deficiency, BMD increases during GH treatment.
  47. Muller H, Gebhardt U, Teske C, Faldum A, Zwiener I, Warmuth Metz M, et al. Post-operative hypothalamic lesions and obesity in childhood craniopharyngioma: results of the multinational prospective trial KRANIOPHARYNGEOM 2000 after 3-year follow-up. Eur J Endocrinol. 2011;165:17-24 pubmed publisher
    Hypothalamic obesity has major impact on prognosis and quality of life (QoL) in childhood craniopharyngioma.
  48. Gokden M, Mrak R. Pituitary adenoma with craniopharyngioma component. Hum Pathol. 2009;40:1189-93 pubmed publisher
    Neoplasms consisting of pituitary adenoma and craniopharyngioma components are rare and are being increasingly recognized. Their histogenesis is not clear. Most represent collision tumors; others are difficult to assess...
  49. Floyd J, Cmelak A, Russell P, Weaver K. Endoscopic, image-guided, transnasal instillation of (32)P for recurrent infrachiasmatic cystic craniopharyngioma. Minim Invasive Neurosurg. 2009;52:137-40 pubmed publisher
  50. Metzler Baddeley C, Jones R. Brief communication: cognitive rehabilitation of executive functioning in a case of craniopharyngioma. Appl Neuropsychol. 2010;17:299-304 pubmed publisher
    ..effectiveness of goal management training for dysexecutive problems following the removal and treatment of a craniopharyngioma in a young woman...
  51. Yomo S, Hayashi M, Chernov M, Tamura N, Izawa M, Okada Y, et al. Stereotactic radiosurgery of residual or recurrent craniopharyngioma: new treatment concept using Leksell gamma knife model C with automatic positioning system. Stereotact Funct Neurosurg. 2009;87:360-7 pubmed publisher
    ..The present study analyzed the initial experience with the application of the original concept of 'robotic microradiosurgery' using Leksell Gamma Knife Model C with automatic positioning system for management of craniopharyngiomas...
  52. Bawden H, Salisbury S, Eskes G, Morehouse R. Neuropsychological functioning following craniopharyngioma removal. J Clin Exp Neuropsychol. 2009;31:140-4 pubmed publisher
    ..The craniopharyngioma group had lower Performance IQ than did the normal control group, but their Performance IQ was comparable to ..
  53. Crowley R, Woods C, Fleming M, Rogers B, Behan L, O Sullivan E, et al. Somnolence in adult craniopharyngioma patients is a common, heterogeneous condition that is potentially treatable. Clin Endocrinol (Oxf). 2011;74:750-5 pubmed publisher
    Somnolence and obesity are prevalent in craniopharyngioma patients. We hypothesized that somnolence was because of obstructive sleep apnoea in craniopharyngioma patients.
  54. Barkhoudarian G, Laws E. Craniopharyngioma: history. Pituitary. 2013;16:1-8 pubmed publisher
    One of the most challenging parasellar tumors, the craniopharyngioma was first described by Friedrich Albert von Zenker in 1857...
  55. Khalatbari M, Borghei Razavi H, Samadian M, Moharamzad Y, Schick U. Isolated primary craniopharyngioma in the cerebellopontine angle. J Clin Neurosci. 2012;19:1516-9 pubmed publisher
    Between January 2000 and January 2011, we diagnosed three patients with isolated craniopharyngioma in the cerebellopontine angle (CPA)...
  56. Visser J, Hukin J, Sargent M, Steinbok P, Goddard K, Fryer C. Late mortality in pediatric patients with craniopharyngioma. J Neurooncol. 2010;100:105-11 pubmed publisher
    Ten year survival rates for patients with craniopharyngioma vary from 24 to 100%...
  57. Sughrue M, Yang I, Kane A, Fang S, Clark A, Aranda D, et al. Endocrinologic, neurologic, and visual morbidity after treatment for craniopharyngioma. J Neurooncol. 2011;101:463-76 pubmed publisher
    ..study aims to summarize and compare the published literature regarding morbidity resulting from treatment of craniopharyngioma. We performed a comprehensive search of the published English language literature to identify studies ..
  58. Tsutsumi S, Yasumoto Y, Ito M. Central pontine and extrapontine myelinolysis in an infant associated with the treatment of craniopharyngioma: case report. Neurol Med Chir (Tokyo). 2008;48:351-4 pubmed
    ..syndrome after undergoing uneventful neuroendoscopic cystostomy for a growing cystic suprasellar craniopharyngioma following microscopic subtotal resection 1 year previously...
  59. Yoshida A, Sen C, Asa S, Rosenblum M. Composite pituitary adenoma and craniopharyngioma?: an unusual sellar neoplasm with divergent differentiation. Am J Surg Pathol. 2008;32:1736-41 pubmed publisher
    ..Alternatively, it may be viewed as a pituitary adenoma showing metaplastic change analogous to the development of squamous cell nests of the pars tuberalis from adenohypophyseal endocrine cells...
  60. Beltran C, Naik M, Merchant T. Dosimetric effect of target expansion and setup uncertainty during radiation therapy in pediatric craniopharyngioma. Radiother Oncol. 2010;97:399-403 pubmed publisher
    Investigate the effect of tumor change and setup uncertainties on target coverage for pediatric craniopharyngioma during RT.
  61. Stamm A, Vellutini E, Balsalobre L. Craniopharyngioma. Otolaryngol Clin North Am. 2011;44:937-52, viii pubmed publisher
    ..The rate of cerebrospinal fluid fistula has improved due to the use of vascularized mucosal flaps for cranial base reconstruction...
  62. Beltran C, Roca M, Merchant T. On the benefits and risks of proton therapy in pediatric craniopharyngioma. Int J Radiat Oncol Biol Phys. 2012;82:e281-7 pubmed publisher
    b>Craniopharyngioma is a pediatric brain tumor whose volume is prone to change during radiation therapy...