neuroectodermal tumors

Summary

Summary: Malignant neoplasms arising in the neuroectoderm, the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems, including some glial cells.

Top Publications

  1. Lo A, Ma Q, Liu D, Junghans R. Anti-GD3 chimeric sFv-CD28/T-cell receptor zeta designer T cells for treatment of metastatic melanoma and other neuroectodermal tumors. Clin Cancer Res. 2010;16:2769-80 pubmed publisher
  2. Giovannini M, Biegel J, Serra M, Wang J, Wei Y, Nycum L, et al. EWS-erg and EWS-Fli1 fusion transcripts in Ewing's sarcoma and primitive neuroectodermal tumors with variant translocations. J Clin Invest. 1994;94:489-96 pubmed
    ..the frequency of EWS fusion transcripts in a series of primary Ewing's sarcomas and peripheral primitive neuroectodermal tumors and cells lines. Type 1 and 2 EWS-Fli1 fusions were demonstrated in 8 cell lines and 14 patient samples...
  3. Fazi B, Melino S, De Rubeis S, Bagni C, Paci M, Piacentini M, et al. Acetylation of RTN-1C regulates the induction of ER stress by the inhibition of HDAC activity in neuroectodermal tumors. Oncogene. 2009;28:3814-24 pubmed publisher
    ..These data demonstrate a molecular mechanism by which RTN-1C controls apoptosis and indicate this protein to be a novel potential target for cancer therapy...
  4. Kohla G, Stockfleth E, Schauer R. Gangliosides with O-acetylated sialic acids in tumors of neuroectodermal origin. Neurochem Res. 2002;27:583-92 pubmed
  5. Pecere T, Gazzola M, Mucignat C, Parolin C, Vecchia F, Cavaggioni A, et al. Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors. Cancer Res. 2000;60:2800-4 pubmed
    ..The growth of human neuroectodermal tumors is inhibited in mice with severe combined immunodeficiency without any appreciable toxic effects on the ..
  6. Haas I, Ganzer U. Does sophisticated diagnostic workup on neuroectodermal tumors have an impact on the treatment of esthesioneuroblastoma?. Onkologie. 2003;26:261-7 pubmed
    ..We have investigated whether improvements in diagnosis of sinonasal neuroectodermal tumors, including esthesioneuroblastomas (ENB), sinonasal neuroendocrine carcinomas (SNEC) and sinonasal ..
  7. Shim H, Oishi S, Fujii N. Chemokine receptor CXCR4 as a therapeutic target for neuroectodermal tumors. Semin Cancer Biol. 2009;19:123-34 pubmed publisher
    ..As an attractive therapeutic target of CXCR4/CXCL12 axis for cancer chemotherapy, development history and application of CXCR4 antagonists are described...
  8. Scursoni A, Galluzzo L, Camarero S, Lopez J, Lubieniecki F, Sampor C, et al. Detection of N-glycolyl GM3 ganglioside in neuroectodermal tumors by immunohistochemistry: an attractive vaccine target for aggressive pediatric cancer. Clin Dev Immunol. 2011;2011:245181 pubmed publisher
    ..Our aim was to evaluate the presence of NeuGc-GM3 in pediatric neuroectodermal tumors by immunohistochemistry...
  9. Fenoglio Preiser C. Gastrointestinal neuroendocrine/neuroectodermal tumors. Am J Clin Pathol. 2001;115 Suppl:S79-93 pubmed
    ..Tumor arrays within a given site, as in the stomach, are compared with one another to highlight their histologic features and differing biologies. General treatment guidelines are also provided...

More Information

Publications98

  1. Zhang Y, Li H. Primitive neuroectodermal tumors of adrenal gland. Jpn J Clin Oncol. 2010;40:800-4 pubmed publisher
    To analyze the clinical and pathological characteristics of adrenal primitive neuroectodermal tumors for a better understanding of the disease.
  2. Cope J, Tsokos M, Miller R. Ewing sarcoma and sinonasal neuroectodermal tumors as second malignant tumors after retinoblastoma and other neoplasms. Med Pediatr Oncol. 2001;36:290-4 pubmed
    ..To update and advance this information, case reports were sought by an extensive review of the literature...
  3. Movahedi Lankarani S, Hruban R, Westra W, Klimstra D. Primitive neuroectodermal tumors of the pancreas: a report of seven cases of a rare neoplasm. Am J Surg Pathol. 2002;26:1040-7 pubmed
    Primitive neuroectodermal tumors (PNETs) have rarely been described in solid organs. We report a series of seven PNETs of the pancreas...
  4. Li M, Bouffet E, Hawkins C, Squire J, Huang A. Molecular genetics of supratentorial primitive neuroectodermal tumors and pineoblastoma. Neurosurg Focus. 2005;19:E3 pubmed
    The supratentorial primitive neuroectodermal tumors (PNETs) are a group of highly malignant lesions primarily affecting young children...
  5. Broniscer A, Nicolaides T, Dunkel I, Gardner S, Johnson J, Allen J, et al. High-dose chemotherapy with autologous stem-cell rescue in the treatment of patients with recurrent non-cerebellar primitive neuroectodermal tumors. Pediatr Blood Cancer. 2004;42:261-7 pubmed
    Recurrent non-cerebellar primitive neuroectodermal tumors (PNETs) carry a dismal prognosis when treated with conventional chemotherapy alone...
  6. Peyromaure M, Vieillefond A, Boucher E, De Pinieux G, Beuzeboc P, Debre B, et al. Primitive neuroectodermal tumor of the prostate. J Urol. 2003;170:182-3 pubmed
  7. Hamann K. Lessons from Jeanetta. J Palliat Med. 2003;6:83-4 pubmed
  8. Uttenreuther Fischer M, Kruger J, Fischer P. Molecular characterization of the anti-idiotypic immune response of a relapse-free neuroblastoma patient following antibody therapy: a possible vaccine against tumors of neuroectodermal origin?. J Immunol. 2006;176:7775-86 pubmed
    ..18. Rabbits vaccinated with GK8 or GK2 (weaker) produced Ab3 against the original target Ag GD2. GK8 may be useful as a tumor vaccine for GD2-positive [corrected] tumors. ..
  9. Gessi M, Giangaspero F, Lauriola L, Gardiman M, Scheithauer B, Halliday W, et al. Embryonal tumors with abundant neuropil and true rosettes: a distinctive CNS primitive neuroectodermal tumor. Am J Surg Pathol. 2009;33:211-7 pubmed publisher
    ..Performed on 2 cases, cytogenetic analysis revealed extra copies of chromosome 2 in both. We believe that the ETANTR represents a histologically distinctive form of CNS embryonal tumor. ..
  10. Sadiq M, Ahmad I, Shuja J, Ahmad K. Primary Ewing sarcoma of the kidney: a case report and treatment review. CEN Case Rep. 2017;6:132-135 pubmed publisher
    Ewing sarcomas/primitive neuroectodermal tumors (ES/PNET) of the kidney are rarely found high-grade malignant tumors, offering poor prognosis...
  11. Papadopoulos N, Tamiolakis D, Lambropoulou M, Alexiadis G, Argyropoulou P, Manavis J, et al. Immunophenotypic profile and FISH analysis in a case of Ewing's sarcoma. In Vivo. 2001;15:359-64 pubmed
    ..Translocation t (11;22) (q24;q12) was found as the main cytogenetic change in this tumor, by means of FISH analysis. ..
  12. White M. Primitive neuroectodermal neoplasia in coho salmon, Oncorhynchus kisutch. Vet Pathol. 2004;41:72-4 pubmed
    ..Based on the close association of these neoplasms with the vertebrae as well as the histologic, ultrastructural, and immunohistochemical findings, these neoplasms were considered to all be primitive neuroectodermal neoplasms. ..
  13. Giammarile F, Chiti A, Lassmann M, Brans B, Flux G. EANM procedure guidelines for 131I-meta-iodobenzylguanidine (131I-mIBG) therapy. Eur J Nucl Med Mol Imaging. 2008;35:1039-47 pubmed publisher
  14. Gross N, Meier R. Chemokines in neuroectodermal cancers: the crucial growth signal from the soil. Semin Cancer Biol. 2009;19:103-10 pubmed publisher
    ..b>Neuroectodermal tumors regroup neoplasms originating from the embryonic neural crest cells, which display clinical and biological ..
  15. Kałwak K, Ussowicz M, Gorczynska E, Toporski J, Turkiewicz D, Bogusławska Jaworska J, et al. Posttransplant adoptive immunotherapy with interleukin-2 in children suffering from neuroectodermal tumors with poor prognosis. Transplant Proc. 2002;34:665-7 pubmed
  16. Lund V. Distant metastases from sinonasal cancer. ORL J Otorhinolaryngol Relat Spec. 2001;63:212-3 pubmed
    ..Notwithstanding this, the frequency with which systemic metastases occurs is such that screening at presentation could not be regarded as cost-effective and is consequently only instituted in the presence of specific symptoms. ..
  17. Coulson J, Edgson J, Woll P, Quinn J. A splice variant of the neuron-restrictive silencer factor repressor is expressed in small cell lung cancer: a potential role in derepression of neuroendocrine genes and a useful clinical marker. Cancer Res. 2000;60:1840-4 pubmed
    ..The NRSF splice variant represents a specific clinical marker that could prove useful in detection of the majority of SCLCs. ..
  18. Billard V, Cheikh M, Delaporte Cerceau S, Raffin Sanson M. [Anaesthesia for endocrine tumor removal]. Ann Fr Anesth Reanim. 2009;28:549-63 pubmed publisher
  19. Santra G, Sinha P, De D, Phaujdar S. Peripheral type of primitive neuroectodermal tumour arising from the left orbital floor. Singapore Med J. 2011;52:e138-40 pubmed
  20. Cianchetti M, Varvares M, Deschler D, Liebsch N, Wang J, Chan A. Risk of sinonasal-cutaneous fistula after treatment for advanced sinonasal cancer. J Surg Oncol. 2012;105:261-5 pubmed
    ..Histologic subtype, T category, and quality of the skin and the underlying supporting tissues after transfacial incision are risk factors for sinonasal-cutaneous fistula formation. ..
  21. Weylandt K, Nebrig M, Jansen Rosseck N, Amey J, Carmena D, Wiedenmann B, et al. ClC-3 expression enhances etoposide resistance by increasing acidification of the late endocytic compartment. Mol Cancer Ther. 2007;6:979-86 pubmed
    ..This study therefore provides first evidence for a role of intracellular CLC proteins in the modulation of cancer drug resistance. ..
  22. Best D, Butz G, Moller K, Coleman W, Thomas D. Molecular analysis of an immature ovarian teratoma with gliomatosis peritonei and recurrence suggests genetic independence of multiple tumors. Int J Oncol. 2004;25:17-25 pubmed
  23. Morales C, Zurita M, Vaquero J. Antitumoral effect of irinotecan (CPT-11) on an experimental model of malignant neuroectodermal tumor. J Neurooncol. 2002;56:219-26 pubmed
    ..These results suggest the utility of CPT-11, by means of intralesional administration, on malignant tumors of the nervous system. ..
  24. Ko K, Kim E, Lee E, Kwon Y. Primary primitive neuroectodermal tumor of the breast: a case report. Korean J Radiol. 2009;10:407-10 pubmed publisher
    Primary primitive neuroectodermal tumors (PNET) are rare malignant tumors, affecting mostly children and adolescents. Only three cases of primary breast PNETs have been reported in the medical literature, with none in Korea...
  25. Reddy A. Advances in biology and treatment of childhood brain tumors. Curr Neurol Neurosci Rep. 2001;1:137-43 pubmed
    ..A growing body of work is aimed at improving the outcome for children with brain tumors not only through clinical trials, but also by focusing on the biologic underpinning of these diseases that have been poorly understood. ..
  26. Kalamarides M, Dewolf E, Couvelard A, Shahidi A, Bouccara D, Cyna Gorse F, et al. Extraaxial primitive neuroectodermal tumor mimicking a vestibular schwannoma: diagnostic and therapeutic difficulties. Report of two cases. J Neurosurg. 2001;94:612-6 pubmed
    Extraaxial cerebellopontine angle (CPA) medulloblastomas and other primitive neuroectodermal tumors (PNETs) are rare tumors. The authors report on two patients with PNETs who presented with progressive audiovestibular symptoms...
  27. Tanaka S, Kamitani H, Amin M, Watanabe T, Oka H, Fujii K, et al. Preliminary individual adjuvant therapy for gliomas based on the results of molecular biological analyses for drug-resistance genes. J Neurooncol. 2000;46:157-71 pubmed
    ..11 glioblastomas, and 7 other malignant neuroepithelial tumors such as medulloblastomas and primitive neuroectodermal tumors) by RT-PCR with the specific primers for O6-methylguanine DNA methyltransferase (MGMT), multidrug-..
  28. Naji M, Al Nahhas A. ??Ga-labelled peptides in the management of neuroectodermal tumours. Eur J Nucl Med Mol Imaging. 2012;39 Suppl 1:S61-7 pubmed publisher
    ..The use of this technique in neuroectodermal tumours has been shown to be superior to all available modalities, but the available data are limited and larger studies are awaited to establish its role in the management of these tumours. ..
  29. Zenali M, Zhang P, Bendel A, Brown R. Morphoproteomic confirmation of constitutively activated mTOR, ERK, and NF-kappaB pathways in Ewing family of tumors. Ann Clin Lab Sci. 2009;39:160-6 pubmed
    ..Based on a literature review, these observations appear to be the first morphoproteomic study of such pathways of convergence in tumors from EFT patients. ..
  30. Lazzari G, Colleoni S, Giannelli S, Brunetti D, Colombo E, Lagutina I, et al. Direct derivation of neural rosettes from cloned bovine blastocysts: a model of early neurulation events and neural crest specification in vitro. Stem Cells. 2006;24:2514-21 pubmed
    ..Moreover, this study provides a source of highly proliferative neural crest precursor cell lines of wide differentiation potential for cell therapy and tissue engineering applications. ..
  31. Shim J, Choi J, Park M, Kim H, Kim J, Kim S, et al. Development of zebrafish medulloblastoma-like PNET model by TALEN-mediated somatic gene inactivation. Oncotarget. 2017;8:55280-55297 pubmed publisher
    ..Tumors induced by rb1 somatic inactivation were characterized as medulloblastoma-like primitive neuroectodermal tumors based on incidence location, histopathological features, and immunohistochemical tests...
  32. Yağcı Küpeli B, Akyuz C, Yalcin B, Varan A, Kutluk T, Buyukpamukcu M. Single institution experience on cancer among adolescents 15-19 years of age. Turk J Pediatr. 2017;59:1-5 pubmed publisher
    ..8%), central nervous system (CNS) tumors (10.9%), osteosarcoma (10.6%), Ewing sarcoma/primitive neuroectodermal tumors (EWN/PNET (9.9%) nasopharyngeal carcinoma (NPC) (9.6%)...
  33. Wang G, Guo F. Primary intramedullary primitive neuroectodermal tumor: A case report and review of the literature. Medicine (Baltimore). 2017;96:e9001 pubmed publisher
    Primary spinal primitive neuroectodermal tumors (PNETs) are highly malignant tumors, which are extremely rare entities and primary intramedullary PNETs are extremely rare...
  34. Saito M, Sakurai S, Motegi A, Saito K, Sano T, Nakajima T. Comparative study using rabbit-derived polyclonal, mouse-derived monoclonal, and rabbit-derived monoclonal antibodies for KIT immunostaining in GIST and other tumors. Pathol Int. 2007;57:200-4 pubmed
    ..At present, pAb A4502 or RabMA Y145 seems to be suitable for KIT immunostaining in formalin-fixed paraffin-embedded tumor specimens, especially in the differential diagnosis of GIST from other mesenchymal tumors. ..
  35. Tannapfel A, Vomschloss S, Karhoff D, Markwarth A, Hengge U, Wittekind C, et al. BRAF gene mutations are rare events in gastroenteropancreatic neuroendocrine tumors. Am J Clin Pathol. 2005;123:256-60 pubmed
    ..Nevertheless, activation of the RAF/mitogen-activated protein kinase pathway might have a causative role in the development of neuroendocrine tumors, independent of BRAF or k-ras-2 mutation...
  36. Massimo L. Marrying pediatric oncology to biological research: cell communication in neuroectodermal tumors: introduction to the workshop. Ann N Y Acad Sci. 2004;1028:56-8 pubmed
  37. Suzuki S, Kitai R, Llena J, Lee S, Goldman J, Shafit Zagardo B. MAP-2e, a novel MAP-2 isoform, is expressed in gliomas and delineates tumor architecture and patterns of infiltration. J Neuropathol Exp Neurol. 2002;61:403-12 pubmed
    ..MAP-2e was not expressed in non-CNS tumors or neuroblastomas. Thus. neuroectodermal tumors that have glial characteristics express this developmental marker of immature glia...
  38. Jenkin R, al Fawaz I, Al Shabanah M, Allam A, Ayas M, Memon M, et al. Metastatic Ewing sarcoma/PNET of bone at diagnosis: prognostic factors--a report from Saudi Arabia. Med Pediatr Oncol. 2001;37:383-9 pubmed
    ..Small primary tumor size and the presence of lung metastases alone were the only significant favorable prognostic factors. Earlier diagnosis will be the basis for better results. ..
  39. Tanigawa H, Onodera H, Maekawa A. Effects of barbital on neuro-oncogenesis in a transplacental carcinogenicity model using F344 rats. J Toxicol Sci. 1995;20:55-65 pubmed
    ..In contrast, lung tumors were not found in group III, while they were observed in groups II and IV. These results suggest that BB has no neuro-carcinogenic activity in the rat transplacental carcinogenesis model. ..
  40. Leighton D. Radiological abnormalities in children born as a result of assisted conception. Australas Radiol. 1995;39:237-42 pubmed
    ..Radiological abnormalities relating to the increased rate of prematurity, a probable increase in the risk of congenital malformations and a number of cases of neural crest tumours seen in these infants will be presented. ..
  41. Duran I, Siu L, Oza A, Chung T, Sturgeon J, Townsley C, et al. Characterisation of the lung toxicity of the cell cycle inhibitor temsirolimus. Eur J Cancer. 2006;42:1875-80 pubmed
    ..The presentation and its severity are variable. The risk of developing this toxicity may be increased among subjects with abnormal pre-treatment pulmonary functions or history of lung disease. ..
  42. Kandemir N, Bahadir B, Gul S, Karadayi N, Ozdamar S. Glioblastoma with primitive neuroectodermal tumor-like features: case report. Turk Neurosurg. 2009;19:260-4 pubmed
    ..The histogenesis and prognostic significance of neuronal differentiation observed in glial tumors are not known yet. Inclusion of this component in pathological reports is important regarding formation of a database for future studies...
  43. Neville A, Herts B. CT characteristics of primary retroperitoneal neoplasms. Crit Rev Comput Tomogr. 2004;45:247-70 pubmed
    ..CT is used to diagnosis and assess the size and extent of retroperitoneal tumors, as well as assess the involvement of organs and vasculature with resection in mind...
  44. Pastorino F, Brignole C, Marimpietri D, Di Paolo D, Zancolli M, Pagnan G, et al. Targeted delivery of oncogene-selective antisense oligonucleotides in neuroectodermal tumors: therapeutic implications. Ann N Y Acad Sci. 2004;1028:90-103 pubmed
    b>Neuroectodermal tumors are highly malignant and increasingly common tumors. Because the cure rate of these neoplasias by conventional treatment is very low, new therapeutic approaches are needed...
  45. Wassberg C, Thorn M, Yuen J, Ringborg U, Hakulinen T. Second primary cancers in patients with cutaneous malignant melanoma: a population-based study in Sweden. Br J Cancer. 1996;73:255-9 pubmed
    ..03-1.88), but no significant associations existed for cancers of the breast, ovary, testis or other endocrine glands. Among tumours of the digestive tract, only colon cancer in men had a significantly increased SIR (1.33, CI = 1.00-1.74)...
  46. Raffaghello L, Cocco C, Corrias M, Airoldi I, Pistoia V. Chemokines in neuroectodermal tumour progression and metastasis. Semin Cancer Biol. 2009;19:97-102 pubmed publisher
    ..Finally, chemokine receptor and function in other neuroectodermal tumours of adulthood (i.e. melanoma and small cell lung cancer) are discussed...
  47. Isaacs H. Cutaneous metastases in neonates: a review. Pediatr Dermatol. 2011;28:85-93 pubmed publisher
    ..Patients with rhabdoid tumor and rhabdomyosarcoma had the lowest survival rates, 4% and 15%, respectively, compared with leukemia, 37.5%, and neuroblastoma, 58%. Overall survival was 39%...
  48. Rome A, Andre N, Michel A, Coze C, Gentet J, Bernard J. [Successful treatment with caspofungin of an invasive candidosis resistant to liposomal amphotericin B in a neutropenic patient]. Arch Pediatr. 2006;13:1556-7 pubmed
  49. Tanimoto A, Arima N, Hayashi R, Hamada T, Matsuki Y, Sasaguri Y. Teratoid carcinosarcoma of the ovary with prominent neuroectodermal differentiation. Pathol Int. 2001;51:829-32 pubmed
    ..This ovarian tumor consisted of frankly malignant components, with prominent neuroectodermal elements mixed with epithelial and mesenchymal elements in an organoid fashion; a quite rare tumor...
  50. Bascoul Mollevi C, Laplanche A, Le Deley M, Kramar A. SAE: an R package for early stopping rules in clinical trials. Comput Methods Programs Biomed. 2011;104:243-8 pubmed publisher
    ..The main difficulty in the implementation of the method is the choice of a priori parameters. Data from an ongoing clinical trial are presented as an example to improve the understanding and the use of the package...
  51. Petrovich S, Konoplia N, Sachivko N, Furmanchuk A, Iunevich E, Dubrovskiĭ A, et al. [Tumors of the central nervous system in children in the Republic of Belarus: morbidity and survival on a population level]. Vopr Onkol. 2002;48:306-10 pubmed
  52. Ohishi Y, Kaku T, Kaneki E, Wake N, Tsuneyoshi M. Malignant ovarian tumor composed of endometrioid adenocarcinoma, clear cell adenocarcinoma, squamous cell carcinoma, yolk sac tumor and immature teratoma with prominent neuroectodermal and rhabdomyosarcomatous differentiation: a case study. Gynecol Oncol. 2007;105:548-52 pubmed
    ..Cases of malignant ovarian tumor composed of müllerian-type epithelial tumor and malignant germ cell tumor are extremely rare...
  53. Dromain C, de Baere T, Baudin E, Galline J, Ducreux M, Boige V, et al. MR imaging of hepatic metastases caused by neuroendocrine tumors: comparing four techniques. AJR Am J Roentgenol. 2003;180:121-8 pubmed
    ..The aim of our prospective study was to assess the MR imaging characteristics of hepatic metastases of neuroendocrine tumors and to determine the optimal MR sequence for their detection...
  54. Algros M, Collonge Rame M, Bedgejian I, Tropet Y, Delattre O, Kantelip B. [Neurectodermal differentiation of extraskeletal myxoid chondrosarcoma: a classical feature?]. Ann Pathol. 2003;23:244-8 pubmed
    ..A documented case of an extraskeletal myxoid chondrosarcoma characterized by a t(9; 17) (q22; q11) translocation with a neuroendocrine and neural differentiation is reported...
  55. Pecere T, Sarinella F, Salata C, Gatto B, Bet A, Dalla Vecchia F, et al. Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin. Int J Cancer. 2003;106:836-47 pubmed
    ..Due to its high accumulation in neuroectodermal tumor cells AE could also kill tumor cells harboring p53 mutant genes. This property would further contribute to AE specific anti-tumor activity and might be exploitable in the clinic...
  56. Miettinen M, McCue P, Sarlomo Rikala M, Rys J, Czapiewski P, Ważny K, et al. GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors. Am J Surg Pathol. 2014;38:13-22 pubmed publisher
    ..Among mesenchymal and neuroectodermal tumors, paragangliomas were usually positive, which sets these tumors apart from epithelial neuroendocrine tumors...
  57. Plougastel B, Zucman J, Peter M, Thomas G, Delattre O. Genomic structure of the EWS gene and its relationship to EWSR1, a site of tumor-associated chromosome translocation. Genomics. 1993;18:609-15 pubmed
    ..22 breakpoint of the t(11;22)(q24;q12) translocation that characterizes Ewing sarcoma and related neuroectodermal tumors. The EWS gene spans about 40 kb of DNA and is encoded by 17 exons...
  58. Doherty G. Multiple endocrine neoplasia type 1. J Surg Oncol. 2005;89:143-50 pubmed
    ..Care of people with MEN-1 requires knowledge of the problems that may arise, and the best approaches to detect and care for the manifestations of this incurable, but manageable, disease...
  59. Wolff J, Finlay J. High-dose chemotherapy in childhood brain tumors. Onkologie. 2004;27:239-45 pubmed
    ..The data suggest benefit in recurrent primitive neuroectodermal tumors (PNET), in newly diagnosed young children with PNET and possibly in young children with newly diagnosed ..
  60. Schmid H, Schoeffter P. Functional activity of the multiligand analog SOM230 at human recombinant somatostatin receptor subtypes supports its usefulness in neuroendocrine tumors. Neuroendocrinology. 2004;80 Suppl 1:47-50 pubmed
  61. Brahmi U, Rajwanshi A, Joshi K, Dey P, Vohra H, Ganguly N, et al. Automated nuclear image morphometry on fine needle aspiration smears of malignant round cell tumors. Anal Quant Cytol Histol. 2001;23:287-90 pubmed
    ..To analyze nuclear image morphometry in fine needle aspiration cytology smears of different groups of malignant round cell tumors (MRCTs) to evaluate its diagnostic role...
  62. Valero G, Escalona A, Leyton R. [Primitive neuroectodermal tumor of the kidney. A case report]. Rev Med Chil. 2001;129:191-5 pubmed
    ..Immunohistochemistry was positive for specific neuronal enolase and CD99. Involvement of the urinary system with primary neuroectodermal tumors is very infrequent.
  63. Chotai N, Tang P, Gopinathan A. Imaging of parotid gland primitive neuroectodermal tumor. J Cancer Res Ther. 2010;6:327-9 pubmed publisher
    ..The findings at surgery and histopathology provided a final diagnosis of parotid gland primitive neuroectodermal tumor. This report emphasizes on the imaging findings of this rare tumor occurring in such an unusual location...
  64. Necchi A, Colecchia M, Nicolai N, Piva L, Catanzaro M, Biasoni D, et al. Towards the definition of the best management and prognostic factors of teratoma with malignant transformation: a single-institution case series and new proposal. BJU Int. 2011;107:1088-94 pubmed publisher
    ..To investigate the optimal management and prognostic factors of patients with malignant transformation (MT) in germ-cell tumour (GCT) by re-evaluating Institutional series...
  65. Besirli K, Arslan C, Tuzun H, Oz B. The primitive neuroectodermal tumor of the heart. Eur J Cardiothorac Surg. 2000;18:619-21 pubmed
    ..Surgical exploration of the tumor showed that it was unresectable and pathology of the biopsy material was primitive neuroectodermal tumor. Medical literature concerning this unusual type of tumor is reviewed...
  66. Mott R, Murphy B, Geisinger K. Ovarian malignant mixed mesodermal tumor with neuroectodermal differentiation: a multifaceted evaluation. Int J Gynecol Pathol. 2010;29:234-8 pubmed publisher
    ..Our findings suggest that the neuroectodermal component may arise from a separate clone or at least evolves at an earlier stage of tumor development...
  67. Saran F. Recent advances in paediatric neuro-oncology. Curr Opin Neurol. 2002;15:671-7 pubmed
    ..Over the last 12-18 months a significant number of institutional and national studies have been reported which are likely to impact on the design of future clinical trials...
  68. De Bustos C, Smits A, Stromberg B, Collins V, Nister M, Afink G. A PDGFRA promoter polymorphism, which disrupts the binding of ZNF148, is associated with primitive neuroectodermal tumours and ependymomas. J Med Genet. 2005;42:31-7 pubmed
    ..The molecular mechanisms responsible for the PDGFRalpha expression in tumours are not known, but in the absence of amplification, changes in transcriptional regulation might be an important factor in this process...
  69. Ishizawa K, Komori T, Hirose T. Stromal cells in hemangioblastoma: neuroectodermal differentiation and morphological similarities to ependymoma. Pathol Int. 2005;55:377-85 pubmed
    ..This result, taken together with the neuroectodermal hypothesis of stromal cells, suggests that hemangioblastomas may occasionally exhibit morphological similarities to ependymomas...
  70. Habermann H, Benesch M, Schips L, Pummer K, Ratschek M, Uggowitzer M, et al. Findings and clinical course of a localized primitive peripheral neuroectodermal tumor of the kidney. Urol Int. 2003;71:319-21 pubmed
    ..We present the findings and clinical course of a patient with localized disease who is free of disease more than 3 years after first presentation. In suspicious cases we recommend to surgically explore renal masses as early as possible...
  71. Reynolds G, Peet A, Arvanitis T. Generating prior probabilities for classifiers of brain tumours using belief networks. BMC Med Inform Decis Mak. 2007;7:27 pubmed
    ..g. combining imaging information with spectroscopy. In this work a method of generating probabilities of tumour class from anatomical location is presented...
  72. Savic S, Tapia C, Grilli B, Rufle A, Bihl M, de Vito Barascud A, et al. Comprehensive epidermal growth factor receptor gene analysis from cytological specimens of non-small-cell lung cancers. Br J Cancer. 2008;98:154-60 pubmed
    ..New criteria for a positive EGFR FISH status to predict response to therapy with EGFR-TKI need to be defined for cytological specimens...
  73. Altaf F, Mansoor I, Jamal A. Histopathological and immuno-histochemical characteristics of primary renal primitive neuroectodermal tumor. Saudi Med J. 2002;23:90-2 pubmed
    ..Primitive neuroectodermal tumors are rare malignant round cell tumors of the kidney...
  74. Milne E, Laurvick C, Blair E, de Klerk N, Charles A, Bower C. Fetal growth and the risk of childhood CNS tumors and lymphomas in Western Australia. Int J Cancer. 2008;123:436-443 pubmed publisher
    ..The associations we observed are consistent with causal pathways involving fetal growth factors...
  75. Liu X, Lin J, Huang J, Li L, Liu L, Xu P. Upregulation of Ku expression in human neuroectodermal tumor cells after retroviral DNA integration. Intervirology. 2002;45:183-7 pubmed
    ..To examine the expression of DNA-dependent protein kinase (DNA-PK); including DNA-PKcs, Ku70 and Ku80 in human neuroectodermal tumor cells with or without retroviral DNA integration...
  76. Vanchinathan V, Marinelli E, Kartha R, Uzieblo A, Ranchod M, Sundram U. A malignant cutaneous neuroendocrine tumor with features of Merkel cell carcinoma and differentiating neuroblastoma. Am J Dermatopathol. 2009;31:193-6 pubmed publisher
    ..To the best of our knowledge, ganglioneuroblastoma-like differentiation has not been previously described in Merkel cell carcinoma...
  77. Okada Y, Kamata S, Akashi T, Kurata M, Nakamura T, Kihara K. Primitive neuroectodermal tumor/Ewing's sarcoma of the urinary bladder: a case report and its molecular diagnosis. Int J Clin Oncol. 2011;16:435-8 pubmed publisher
    ..Exact diagnosis is crucial for deciding the treatment strategy for rare bladder tumors consisting of small round cells...
  78. Taddei P, Mahajan A, Mirkovic D, Zhang R, Giebeler A, Kornguth D, et al. Predicted risks of second malignant neoplasm incidence and mortality due to secondary neutrons in a girl and boy receiving proton craniospinal irradiation. Phys Med Biol. 2010;55:7067-80 pubmed publisher
    ..Lung cancer predominated the risk of SMN mortality for both patients. This study suggests that the risks of SMN incidence and mortality from neutrons may be greater for girls than for boys treated with proton CSI...
  79. Miller K, Holcomb G. Laparoscopic adrenalectomy and esophagomyotomy. Semin Pediatr Surg. 2002;11:237-44 pubmed
    ..The goal of this article is to familiarize the reader with the current laparoscopic approach to benign pediatric adrenal conditions and esophageal motility disorders in children...
  80. Hayes S, Jani T, Rahman S, Jogai S, Harries P, Salib R. Solitary extra-skeletal sinonasal metastasis from a primary skeletal Ewing's sarcoma. J Laryngol Otol. 2011;125:861-4 pubmed publisher
    ..We describe a unique case of an isolated extra-skeletal metastasis from a skeletal Ewing's sarcoma primary, arising in the right sinonasal cavity of a young man who presented with severe epistaxis and periorbital cellulitis...
  81. Hirato J, Nakazato Y. Pathology of pineal region tumors. J Neurooncol. 2001;54:239-49 pubmed
    ..In contrast, pineoblastomas are embryonal tumors resembling primitive neuroectodermal tumors (PNET)...
  82. Bahk W, Chang E, Bae J, Chun K, Lee A, Rho S, et al. Primary cutaneous Ewing's sarcoma/primitive neuroectodermal tumor manifesting numerous small and huge ulcerated masses: its complete remission by chemotherapy and magnetic resonance imaging findings. Skeletal Radiol. 2010;39:595-600 pubmed publisher
    ..We present magnetic resonance imaging (MRI) findings and clinical course of a unique case of primary cutaneous ES/PNET presenting as numerous huge masses with severe ulceration on them...
  83. Györke T, Zajic T, Lange A, Schäfer O, Moser E, Makó E, et al. Impact of FDG PET for staging of Ewing sarcomas and primitive neuroectodermal tumours. Nucl Med Commun. 2006;27:17-24 pubmed
    ..Our purpose was to evaluate the value of [18F]fluorodeoxyglucose positron emission tomography (FDG PET) in patients with Ewing tumours...
  84. Vang R, Taubenberger J, Mannion C, Bijwaard K, Malpica A, Ordonez N, et al. Primary vulvar and vaginal extraosseous Ewing's sarcoma/peripheral neuroectodermal tumor: diagnostic confirmation with CD99 immunostaining and reverse transcriptase-polymerase chain reaction. Int J Gynecol Pathol. 2000;19:103-9 pubmed
    ..To our knowledge, these are the first reported cases of vaginal and vulvar Ewing's sarcoma/peripheral neuroectodermal tumor, confirmed with molecular genetic analysis, in the English literature...
  85. Long P, Schulman F, Koestner A, Fix A, Campbell M, Cameron K. Primitive neuroectodermal tumor in a two-month-old black and white Colobus monkey. Vet Pathol. 1998;35:64-7 pubmed
    ..The extracranial tumors were synaptophysin (SYN)-positive, glial fibrillary acidic protein (GFAP)-negative, and neurofilament protein (NFP)-negative, while the intracranial tumor was SYN-positive, GFAP-positive, and NFP-negative...
  86. Vojkovic S, Kristjanson L. Case study report of two palliative care patients receiving intracerebroventricular (ICV) analgesia. J Palliat Care. 2003;19:280-3 pubmed
  87. Zawitkowska Klaczynska J, Katski K, Wozniak M, Kowalczyk J. Characteristics and outcome of children with primary soft tissue sarcomas of extremities. Med Wieku Rozwoj. 2004;8:169-74 pubmed
    ..To determine the characteristics and outcome or patients with primary soft tissue sarcomas of extremities in children...
  88. Parham D. Neuroectodermal and neuroendocrine tumors principally seen in children. Am J Clin Pathol. 2001;115 Suppl:S113-28 pubmed
    b>Neuroectodermal tumors comprise a large proportion of childhood neoplasms...
  89. Bisogno G, Carli M, Stevens M, Oberlin O, Treuner J, Scarzello G, et al. Intensive chemotherapy for children and young adults with metastatic primitive neuroectodermal tumors of the soft tissue. Bone Marrow Transplant. 2002;30:297-302 pubmed
    ..04). In conclusion, despite the high CR rate, intensive chemotherapy with or without high-dose melphalan appeared to have little impact on the survival of patients with metastatic extraosseus PNET...