seminoma

Summary

Summary: A radiosensitive, malignant neoplasm of the testis, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. There are three variants: classical (typical), the most common type; anaplastic; and spermatocytic. The classical seminoma is composed of fairly well differentiated sheets or cords of uniform polygonal or round cells (seminoma cells), each cell having abundant clear cytoplasm, distinct cell membranes, a centrally placed round nucleus, and one or more nucleoli. In the female, a grossly and histologically identical neoplasm, known as dysgerminoma, occurs. (Dorland, 27th ed)

Top Publications

  1. Rago V, Romeo F, Giordano F, Ferraro A, Ando S, Carpino A. Identification of ERbeta1 and ERbeta2 in human seminoma, in embryonal carcinoma and in their adjacent intratubular germ cell neoplasia. Reprod Biol Endocrinol. 2009;7:56 pubmed publisher
    ..previously reported in testicular germ cell tumours and, particularly, an ERbeta down-regulation was evidenced in seminoma and embryonal carcinoma...
  2. Xiao G, Mccash S, Unger P. Paraganglia mimicking metastatic seminomatous tumor. Int J Surg Pathol. 2011;19:534-7 pubmed publisher
    ..0 to 3.0 mm in size. These cell groups were initially interpreted as recurrent metastatic seminoma, but were later reinterpreted as paraganglionic cells, which were confirmed by immunohistochemical analysis...
  3. Kristensen D, Mlynarska O, Nielsen J, Jacobsen G, Rajpert De Meyts E, Almstrup K. Heterogeneity of chromatin modifications in testicular spermatocytic seminoma point toward an epigenetically unstable phenotype. Cancer Genet. 2012;205:425-31 pubmed publisher
    Testicular spermatocytic seminoma (SS) is a rare tumor type predominantly found in elderly men. It is thought to originate from spermatogonia and shows cytological and genetic heterogeneity...
  4. Chevalier N, Vega A, Bouskine A, Siddeek B, Michiels J, Chevallier D, et al. GPR30, the non-classical membrane G protein related estrogen receptor, is overexpressed in human seminoma and promotes seminoma cell proliferation. PLoS ONE. 2012;7:e34672 pubmed publisher
    ..of this study was to demonstrate that GPER was overexpressed in testicular tumours and was able to trigger JKT-1 seminoma cell proliferation...
  5. Looijenga L. Spermatocytic seminoma: toward further understanding of pathogenesis. J Pathol. 2011;224:431-3 pubmed publisher
    ..developmental models for this type of germ cell tumour have been proposed and it is clear that spermatocytic seminoma has a pathogenesis independent from that of seminoma...
  6. Schmoll H, Osanto S, Kawai K, Einhorn L, Fizazi K. Advanced seminoma and nonseminoma: SIU/ICUD Consensus Meeting on Germ Cell Tumors (GCT), Shanghai 2009. Urology. 2011;78:S456-68 pubmed publisher
    ..the potential role of carboplatin as single agent or combined with etoposide and bleomycin for advanced seminoma. From prospective randomized trials and available data from additional sources, a European standard has been ..
  7. Subramanian V, Nguyen C, Stephenson A, Klein E. Complications of open primary and post-chemotherapy retroperitoneal lymph node dissection for testicular cancer. Urol Oncol. 2010;28:504-9 pubmed publisher
    ..We sought to compare the complication profile of primary (P-) and post-chemotherapy (PC-) RPLND using a standardized complication grading scale...
  8. Wallacides A, Chesnel A, Ajj H, Chillet M, Flament S, Dumond H. Estrogens promote proliferation of the seminoma-like TCam-2 cell line through a GPER-dependent ER?36 induction. Mol Cell Endocrinol. 2012;350:61-71 pubmed publisher
    b>Seminoma, originated from carcinoma in situ cells (CIS), is one of the main causes of cancer in young men. Postpubertal development of these testicular germ cell tumors suggests a hormone-sensitive way of CIS cell proliferation induction...
  9. Mauro V, Carette D, Chevallier D, Michiels J, Segretain D, Pointis G, et al. Reg I protein in healthy and seminoma human testis. Histol Histopathol. 2008;23:1195-203 pubmed publisher
    ..normal rodent and human testes where germ cells normally proliferate and differentiate into spermatozoa, and in seminoma testis, the most common cancer of young men...

More Information

Publications83

  1. McIver S, Loveland K, Roman S, Nixon B, Kitazawa R, McLaughlin E. The chemokine CXCL12 and its receptor CXCR4 are implicated in human seminoma metastasis. Andrology. 2013;1:517-29 pubmed publisher
    b>Seminoma and non-seminoma tumours increasingly occur within the western population. These tumours originate from carcinoma in situ (CIS) cells, which arise from dysfunctional gonocytes...
  2. Lawrentschuk N, Fleshner N. Clinical stage I seminoma: the case for surveillance. World J Urol. 2009;27:433-9 pubmed publisher
    ..This takes into consideration the fact that a small number of men with clinical stage I (CSI) seminoma on surveillance will recur but are salvageable with equivalent outcome compared to those having adjuvant ..
  3. Grieco V, Banco B, Giudice C, Mosca F, Finazzi M. Immunohistochemical expression of the KIT protein (CD117) in normal and neoplastic canine testes. J Comp Pathol. 2010;142:213-7 pubmed publisher
    ..Seminomas were subclassified on the basis of expression of placental alkaline phosphatase (PLAP) as classical seminoma (SE; PLAP positive; n=5) or spermatocytic seminoma (SS; PLAP negative; n=5)...
  4. Senadhi V, Dutta S. Testicular seminoma metastasis to the gastrointestinal tract and the necessity of surgery. J Gastrointest Cancer. 2012;43:499-501 pubmed publisher
    ..We present a case of chemoresistant pure testicular seminoma with metastasis to the duodenum with a complication of a massive upper GI bleed requiring emergent surgery.
  5. Cummins S, Yau T, Huddart R, Dearnaley D, Horwich A. Surveillance in stage I seminoma patients: a long-term assessment. Eur Urol. 2010;57:673-8 pubmed publisher
    Following orchidectomy patients with stage I seminoma of the testis may be managed by either surveillance or adjuvant treatment. In view of the very high cure rate, it is important to analyse long-term outcomes...
  6. Waheeb R, Hofmann M. Human spermatogonial stem cells: a possible origin for spermatocytic seminoma. Int J Androl. 2011;34:e296-305; discussion e305 pubmed publisher
    ..However, morphological appearance and overall immunohistochemical profile of these tumours indicate that the cell of origin could also be a spermatogonial stem cell. ..
  7. Vossen C, Horwich A, Daugaard G, Van Poppel H, Osanto S. Patterns of care in the management of seminoma stage I: results from a European survey. BJU Int. 2012;110:524-31 pubmed publisher
    ..late events such as second malignancy and cardiovascular events for the three post-orchidectomy strategies in seminoma stage I patients has led to debates about whether the three strategies are equally effective and safe...
  8. Kollmannsberger C, Tyldesley S, Moore C, Chi K, Murray N, Daneshmand S, et al. Evolution in management of testicular seminoma: population-based outcomes with selective utilization of active therapies. Ann Oncol. 2011;22:808-14 pubmed publisher
    ..evolution of treatment with increased use of active surveillance for stage I disease as well as risk-adapted chemotherapy for disseminated disease and associated outcomes of testicular seminoma in a contemporary population-based cohort.
  9. Ruf C, Linbecker M, Port M, Riecke A, Schmelz H, Wagner W, et al. Predicting metastasized seminoma using gene expression. BJU Int. 2012;110:E14-20 pubmed publisher
    ..Gene expression analysis in testis cancer allowed discrimination between the different histological subtypes (seminoma and non-seminoma) as well as testis cancer and normal testis tissue...
  10. Aggarwal N, Parwani A. Spermatocytic seminoma. Arch Pathol Lab Med. 2009;133:1985-8 pubmed publisher
    Spermatocytic seminoma is a rare germ cell tumor distinct from classical seminoma, both clinically and pathologically...
  11. Giannis M, Aristotelis B, Vassiliki K, Ioannis A, Konstantinos S, Nikolaos A, et al. Cisplatin-based chemotherapy for advanced seminoma: report of 52 cases treated in two institutions. J Cancer Res Clin Oncol. 2009;135:1495-500 pubmed publisher
    ..strategy in order to optimize treatment outcomes while maintaining acceptable toxicity in patients with advanced seminoma. Fifty-two patients with advanced pure seminoma were retrospectively evaluated...
  12. Davis Dao C, Siegmund K, Vandenberg D, Skinner E, Coetzee G, Thomas D, et al. Heterogenous effect of androgen receptor CAG tract length on testicular germ cell tumor risk: shorter repeats associated with seminoma but not other histologic types. Carcinogenesis. 2011;32:1238-43 pubmed publisher
    ..However, risk of seminoma was significantly associated with shorter CAG repeat length [CAG 20-21 versus CAG ? 19: OR = 0.82 (95% CI: 0.43-1...
  13. Vesprini D, Chung P, Tolan S, Gospodarowicz M, Jewett M, O Malley M, et al. Utility of serum tumor markers during surveillance for stage I seminoma. Cancer. 2012;118:5245-50 pubmed publisher
    ..and lactate dehydrogenase (LDH) are often measured as part of surveillance protocols in patients with stage I seminoma. In this study, the authors evaluated the utility of routine measurement of these markers in the detection of ..
  14. Hoffman K, Chen M, Punglia R, Beard C, D Amico A. Influence of year of diagnosis, patient age, and sociodemographic status on recommending adjuvant radiation treatment for stage I testicular seminoma. J Clin Oncol. 2008;26:3937-42 pubmed publisher
    Adjuvant radiation therapy (ART) for stage I seminoma can cause adverse late effects and alternative postorchiectomy management strategies have been developed...
  15. Chung P, Mayhew L, Warde P, Winquist E, Lukka H. Management of stage I seminomatous testicular cancer: a systematic review. Clin Oncol (R Coll Radiol). 2010;22:6-16 pubmed publisher
    The treatment options available for the management of stage I seminoma consist of either a surveillance strategy or adjuvant therapy after orchidectomy. A systematic review was undertaken to identify the optimal management strategy...
  16. Bachner M, Loriot Y, Gross Goupil M, Zucali P, Horwich A, Germa Lluch J, et al. 2-¹?fluoro-deoxy-D-glucose positron emission tomography (FDG-PET) for postchemotherapy seminoma residual lesions: a retrospective validation of the SEMPET trial. Ann Oncol. 2012;23:59-64 pubmed publisher
    ..positron emission tomography (FDG-PET) has been recommended in international guidelines in the evaluation of postchemotherapy seminoma residuals. Our trial was designed to validate these recommendations in a larger group of patients.
  17. Horn T, Schulz S, Maurer T, Gschwend J, Kübler H. Poor efficacy of BEP polychemotherapy in metastatic spermatocytic seminoma. Med Oncol. 2011;28 Suppl 1:S423-5 pubmed publisher
    Metastatic spermatocytic seminoma is an extremely rare disease. No chemotherapeutic regimen is established and the use of adjuvant radiation therapy after orchiectomy as frequently performed for classical seminoma is unclear...
  18. Ajj H, Chesnel A, Pinel S, Plenat F, Flament S, Dumond H. An alkylphenol mix promotes seminoma derived cell proliferation through an ERalpha36-mediated mechanism. PLoS ONE. 2013;8:e61758 pubmed publisher
    ..were monitored after exposure to a realistic mixture of 4-tert-octylphenol and 4-nonylphenol of either TCam-2 seminoma derived cells, NT2/D1 embryonal carcinoma cells or testis tumor in xenografted nude mice...
  19. Esposito F, Boscia F, Franco R, Tornincasa M, Fusco A, Kitazawa S, et al. Down-regulation of oestrogen receptor-? associates with transcriptional co-regulator PATZ1 delocalization in human testicular seminomas. J Pathol. 2011;224:110-20 pubmed publisher
  20. Ferranti F, Muciaccia B, Ricci G, Dovere L, Canipari R, Magliocca F, et al. Glial cell line-derived neurotrophic factor promotes invasive behaviour in testicular seminoma cells. Int J Androl. 2012;35:758-68 pubmed publisher
    ..in the onset and progression of testicular germ cell tumours, we analysed GFRA1 and Ret expression patterns in seminoma samples...
  21. Xu N, Li F, Tian R, Shao M, Liu L, Guo K. A rare case of bilateral sequential spermatocytic seminoma. World J Surg Oncol. 2013;11:175 pubmed publisher
    Spermatocytic seminoma (SS) is a rare testicular neoplasm characterized by a palpable, painless, slowly enlarging mass in the testis. Even more rare is a synchronous bilateral presentation...
  22. Clasen J, Schmidberger H, Souchon R, Weissbach L, Hartmann M, Hartmann J, et al. What is the value of routine follow-up in stage I seminoma after paraaortic radiotherapy?: an analysis of the German Testicular Cancer Study Group (GTCSG) in 675 prospectively followed patients. Strahlenther Onkol. 2009;185:349-54 pubmed publisher
    Routine posttreatment surveillance is recommended after adjuvant radiotherapy for stage I seminoma. However, systematic studies on the value of follow-up in these patients are missing...
  23. Kamba T, Kamoto T, Okubo K, Teramukai S, Kakehi Y, Matsuda T, et al. Outcome of different post-orchiectomy management for stage I seminoma: Japanese multi-institutional study including 425 patients. Int J Urol. 2010;17:980-7 pubmed publisher
    To clarify the contemporary clinical outcome of stage I seminoma and to provide information on treatment options to patients.
  24. Chevalier N, Paul Bellon R, Camparo P, Michiels J, Chevallier D, Fenichel P. Genetic variants of GPER/GPR30, a novel estrogen-related G protein receptor, are associated with human seminoma. Int J Mol Sci. 2014;15:1574-89 pubmed publisher
    ..We reported two distinct effects of estrogens and/or xeno-estrogens on in vitro human seminoma-derived cells proliferation: (1) an antiproliferative effect via a classical estrogen receptor beta-dependent ..
  25. Bode P, Barghorn A, Fritzsche F, Riener M, Kristiansen G, Knuth A, et al. MAGEC2 is a sensitive and novel marker for seminoma: a tissue microarray analysis of 325 testicular germ cell tumors. Mod Pathol. 2011;24:829-35 pubmed
    ..In contrast, KIT was positive in 94% of seminoma but also in 8% of embryonal carcinomas...
  26. Koppad S, Sonawane S, Kapoor V, Deshmukh A, Borole K. Bilateral synchronous spermatocytic seminoma: a rare case report from rural India and literature review. Pan Afr Med J. 2012;13:34 pubmed
    Spermatocytic Seminoma is an unusual germ cell tumour known to arise from testis only. It is associated with good prognosis. Testicular tumours as such are uncommon in Asia as compared to western countries...
  27. Djeffal C, Demailly M, Tillou X, Saint F, Petit J. [Place of serum HCG assay in the follow-up of non-HCG-secreting testicular seminomas]. Prog Urol. 2008;18:654-6 pubmed publisher
    ..variations of serum total HCG levels in patients with normal baseline levels for the surveillance of treated testicular seminomas in order to determine the value of assay of this tumour marker in the follow-up of testicular seminoma.
  28. Ruf C, Khalili Harbi N, Sachs S, Isbarn H, Wagner W, Matthies C, et al. The search for biomarkers of metastatic seminoma. J Urol. 2013;190:1046-51 pubmed publisher
    We screened 90 potential parameters as biomarkers of metastatic seminoma to facilitate detection and eliminate unnecessary therapeutic or diagnostic efforts.
  29. Osswald M, Harlan L, Penson D, Stevens J, Clegg L. Treatment of a population based sample of men diagnosed with testicular cancer in the United States. Urol Oncol. 2009;27:604-10 pubmed publisher
    ..Testicular cancer is the most common cancer in men age 25 to 35 years. We examined therapy, compliance with guidelines, and survival in a population based sample of men newly diagnosed with testicular cancer...
  30. Brait M, Maldonado L, Begum S, Loyo M, Wehle D, Tavora F, et al. DNA methylation profiles delineate epigenetic heterogeneity in seminoma and non-seminoma. Br J Cancer. 2012;106:414-23 pubmed publisher
    ..The purpose of this study was to determine the methylation frequency of several cancer-related genes in different histological types of testicular cancer and normal testis tissues (NT)...
  31. Garcia del Muro X, Maroto P, Gumà J, Sastre J, López Brea M, Arranz J, et al. Chemotherapy as an alternative to radiotherapy in the treatment of stage IIA and IIB testicular seminoma: a Spanish Germ Cell Cancer Group Study. J Clin Oncol. 2008;26:5416-21 pubmed publisher
    To assess the long-term efficacy and toxicity of front-line cisplatin-based chemotherapy in patients with stage IIA or IIB testicular seminoma.
  32. Classen J, Souchon R, Hehr T, Hartmann M, Hartmann J, Bamberg M. Posttreatment surveillance after paraaortic radiotherapy for stage I seminoma: a systematic analysis. J Cancer Res Clin Oncol. 2010;136:227-32 pubmed publisher
    The extent and duration of routine follow-up after paraaortic (PA) radiotherapy for stage I seminoma remain controversial in terms of efficacy, costs of technical investigations and long-term morbidity.
  33. Mesa H, Rawal A, Rezcallah A, Iwamoto C, Niehans G, Druck P, et al. "Burned out" testicular seminoma presenting as a primary gastric malignancy. Int J Clin Oncol. 2009;14:74-7 pubmed publisher
    ..ulcerative mucosal lesion was found to be due to a metastasis from an occult, "burned-out" testicular seminoma. This case describes the radiological and pathological features that helped differentiate this rare situation ..
  34. Trivedi P, Pasricha S, Gupta A. Spermatocytic seminoma associated with undifferentiated sarcoma: a rare case report. Indian J Pathol Microbiol. 2011;54:138-40 pubmed publisher
    The presence of sarcomatous element transforms the usually innocuous spermatocytic seminoma into a highly aggressive neoplasm...
  35. Arvold N, Catalano P, Sweeney C, Hoffman K, Nguyen P, Balboni T, et al. Barriers to the implementation of surveillance for stage I testicular seminoma. Int J Radiat Oncol Biol Phys. 2012;84:383-9 pubmed publisher
    Postorchiectomy adjuvant radiotherapy (RT) for Stage I seminoma can be associated with long-term toxicity, and management strategies with a lower treatment burden achieve the same excellent cure rate...
  36. Mead G, Fossa S, Oliver R, Joffe J, Huddart R, Roberts J, et al. Randomized trials in 2466 patients with stage I seminoma: patterns of relapse and follow-up. J Natl Cancer Inst. 2011;103:241-9 pubmed publisher
    From July 1, 1989, through March 31, 2001, 2466 patients with stage I seminoma were evaluated in three randomized noninferiority trials: the TE10, TE18, and TE19 trials. We analyzed mature results of these studies.
  37. Bouskine A, Nebout M, Brucker Davis F, Benahmed M, Fenichel P. Low doses of bisphenol A promote human seminoma cell proliferation by activating PKA and PKG via a membrane G-protein-coupled estrogen receptor. Environ Health Perspect. 2009;117:1053-8 pubmed publisher
    ..Thus, several mechanisms have been suggested to explain how they could affect male germ cell proliferation at low environmental relevant concentrations...
  38. Bouskine A, Vega A, Nebout M, Benahmed M, Fenichel P. Expression of embryonic stem cell markers in cultured JKT-1, a cell line derived from a human seminoma. Int J Androl. 2010;33:54-63 pubmed publisher
    ..They share some pluripotency stem-cell markers which may help to distinguish between seminoma, the most frequent TGCTs and non-seminoma tumours, such as embryonal carcinoma, teratocarcinoma or ..
  39. Yu C, Hwang D, Yhee J, Kim J, Im K, Nho W, et al. Comparative immunohistochemical characterization of canine seminomas and Sertoli cell tumors. J Vet Sci. 2009;10:1-7 pubmed
    ..All the main markers in current routine use are discussed as well as potential useful markers for benign and malignant tumors, and tumor progression...
  40. Franco R, Boscia F, Gigantino V, Marra L, Esposito F, Ferrara D, et al. GPR30 is overexpressed in post-puberal testicular germ cell tumors. Cancer Biol Ther. 2011;11:609-13 pubmed
    ..in GC1 and TCam-2 cell lines, respectively derived from immortalized type B murine spermatogonia and human seminoma. Our results indicate that GPR30 could be a potential therapeutic target; the design of a specific GPR30 ..
  41. Hemminki K, Liu H, Sundquist J. Second cancers after testicular cancer diagnosed after 1980 in Sweden. Ann Oncol. 2010;21:1546-51 pubmed publisher
    Testicular cancer treatment has become standardized in the 1980s involving radiotherapy preferentially for seminoma and chemotherapy for nonseminoma...
  42. Ferlin A, Ganz F, Pengo M, Selice R, Frigo A, Foresta C. Association of testicular germ cell tumor with polymorphisms in estrogen receptor and steroid metabolism genes. Endocr Relat Cancer. 2010;17:17-25 pubmed publisher
    ..561, 95% CI=2.615-7.955) compared with homozygous carriage of the major G allele. The risk was increased both for seminoma (OR=5.327, 95% CI=2.857-9.931) and for nonseminoma (OR=3.222, 95% CI=1.471-7.059)...
  43. Aparicio J, Sastre J, Germà J, Isla D. SEOM clinical guidelines for diagnosis and treatment of testicular seminoma (2010). Clin Transl Oncol. 2011;13:560-4 pubmed publisher
    ..Residual lesions must be managed by surveillance if they are smaller than 3 cm, while those larger than 3 cm should be evaluated by means of PET. Surgery is only recommended in PET-positive lesions...
  44. Coulier B, Lefebvre Y, De Visscher L, Bourgeois A, Montfort L, Clausse M, et al. Metastases of clinically occult testicular seminoma mimicking primary extragonadal retroperitoneal germ cell tumors. JBR-BTR. 2008;91:139-44 pubmed
    ..Whether extragonadal germ cell tumors develop primarily in the retroperitoneum or whether they are essentially metastases of a primary testicular tumor has long been debated and remains controversial...
  45. Yoshida T, Kakimoto K, Takezawa K, Arai Y, Ono Y, Meguro N, et al. Surveillance following orchiectomy for stage I testicular seminoma: long-term outcome. Int J Urol. 2009;16:756-9 pubmed publisher
    To report the long-term outcome of surveillance for stage I seminoma at a single institution in Japan.
  46. Netto G, Nakai Y, Nakayama M, Jadallah S, Toubaji A, Nonomura N, et al. Global DNA hypomethylation in intratubular germ cell neoplasia and seminoma, but not in nonseminomatous male germ cell tumors. Mod Pathol. 2008;21:1337-44 pubmed publisher
    ..That is, IGCNU cells and seminoma cells remain unmethylated, whereas all other histological types appear to arise after de novo methylation.
  47. Cooper D, L Esperance J, Christman M, Auge B. Testis cancer: a 20-year epidemiological review of the experience at a regional military medical facility. J Urol. 2008;180:577-81; discussion 581-2 pubmed publisher
    ..Testis cancer is the most common solid malignancy in the young adult population and the incidence in this population is increasing. We present a 20-year epidemiological review of testis cancers treated at our institution...
  48. Mok G, Warde P. Management of stage I testicular seminoma. Hematol Oncol Clin North Am. 2011;25:503-16, vii-iii pubmed publisher
    Adjuvant treatment options for stage I seminoma include surveillance, radiation, and hemotherapy...
  49. Tandstad T, Smaaland R, Solberg A, Bremnes R, Langberg C, Laurell A, et al. Management of seminomatous testicular cancer: a binational prospective population-based study from the Swedish norwegian testicular cancer study group. J Clin Oncol. 2011;29:719-25 pubmed publisher
    ..The aim was to standardize care for all patients with seminoma to further improve the good results expected for this disease.
  50. Warde P, Huddart R, Bolton D, Heidenreich A, Gilligan T, Fossa S. Management of localized seminoma, stage I-II: SIU/ICUD Consensus Meeting on Germ Cell Tumors (GCT), Shanghai 2009. Urology. 2011;78:S435-43 pubmed publisher
    The treatment of patients with Stage I-II seminoma has changed considerably in the past decade, and in November 2009, an International Consensus meeting was held under the sponsorship of the Union for International Cancer Control (UICC), ..
  51. Beard C, Travis L, Chen M, Arvold N, Nguyen P, Martin N, et al. Outcomes in stage I testicular seminoma: a population-based study of 9193 patients. Cancer. 2013;119:2771-7 pubmed publisher
    ..have quantified temporal patterns of cause-specific mortality in contemporary cohorts of men with early-stage seminoma. Given that several management strategies can be applied in these patients, each resulting in excellent long-term ..
  52. Guido C, Panza S, Santoro M, Avena P, Panno M, Perrotta I, et al. Estrogen receptor beta (ER?) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene. Cell Cycle. 2012;11:2911-21 pubmed publisher
    Testicular germ cell tumors are the most common tumor in male and the least studied. We focused on human seminoma using the TCAM2 cell line...
  53. Nødtvedt A, Gamlem H, Gunnes G, Grotmol T, Indrebø A, Moe L. Breed differences in the proportional morbidity of testicular tumours and distribution of histopathologic types in a population-based canine cancer registry. Vet Comp Oncol. 2011;9:45-54 pubmed publisher
    ..Breed differences in the distribution of histopathologic types were observed. Shetland sheepdog and Collie were most commonly diagnosed with Sertoli cell tumours, while all tumours from Norwegian elkhound in this material were seminomas...
  54. Kim J, Yu C, Yhee J, Im K, Kim N, Sur J. Canine classical seminoma: a specific malignant type with human classifications is highly correlated with tumor angiogenesis. BMC Cancer. 2010;10:243 pubmed publisher
    Human seminoma is classified as classical seminoma (SE) and spermatocytic seminoma (SS). Human SE is known to be more malignant and metastasizing more frequently than SS...
  55. Looijenga L, Hersmus R, de Leeuw B, Stoop H, Cools M, Oosterhuis J, et al. Gonadal tumours and DSD. Best Pract Res Clin Endocrinol Metab. 2010;24:291-310 pubmed publisher
  56. Pectasides D, Pectasides E, Constantinidou A, Aravantinos G. Stage I testicular seminoma: management and controversies. Crit Rev Oncol Hematol. 2009;71:22-8 pubmed publisher
    Seminomas constitute more than half of testicular germ-cell tumours and 70-80% of patients with seminoma present with clinical stage I disease. Post-orchiectomy, management options include irradiation, surveillance or chemotherapy...
  57. Chen Y, Chiu R, Lee P, Beneck D, Jin B, Old L. Chromosome X-encoded cancer/testis antigens show distinctive expression patterns in developing gonads and in testicular seminoma. Hum Reprod. 2011;26:3232-43 pubmed publisher
    ..Cancer/testis (CT) antigens are cancer antigens normally expressed in adult testicular germ cells. The expression of chromosome X-encoded CT antigens (CT-X antigens) in human fetal gonads and in testicular seminomas was examined...
  58. Nettersheim D, Gillis A, Biermann K, Looijenga L, Schorle H. The seminoma cell line TCam-2 is sensitive to HDAC inhibitor depsipeptide but tolerates various other chemotherapeutic drugs and loss of NANOG expression. Genes Chromosomes Cancer. 2011;50:1033-42 pubmed publisher
    ..Also, it is not known why CIS gives rise to seminoma in some patients and to non-seminoma in the others...
  59. Haugnes H, Aass N, Fossa S, Dahl O, Klepp O, Wist E, et al. Predicted cardiovascular mortality and reported cardiovascular morbidity in testicular cancer survivors. J Cancer Surviv. 2008;2:128-37 pubmed publisher
  60. Rago V, Romeo F, Giordano F, Maggiolini M, Carpino A. Identification of the estrogen receptor GPER in neoplastic and non-neoplastic human testes. Reprod Biol Endocrinol. 2011;9:135 pubmed publisher
    ..Recently, a G-protein-coupled-receptor (GPER) has been suggested as being involved in rapid responses to estrogens in different normal and tumor cells...
  61. Siekiera J, Małkowski B, Jozwicki W, Jasiński M, Wronczewski A, Pietrzak T, et al. Can we rely on PET in the follow-up of advanced seminoma patients?. Urol Int. 2012;88:405-9 pubmed publisher
    The management of residuals after completion of chemotherapy in advanced seminoma is controversial. It has been proposed that fluorodeoxyglucose-positron emission tomography (FDG-PET) can be used as a follow-up...
  62. Ulbright T, Young R. Seminoma with conspicuous signet ring cells: a rare, previously uncharacterized morphologic variant. Am J Surg Pathol. 2008;32:1175-81 pubmed publisher
    ..The tumors occurred in men, 24 and 69 years of age, who presented with testicular masses; 1 seminoma was a component of a mixed germ cell tumor and the other was pure...
  63. Lim J, Goriely A, Turner G, Ewen K, Jacobsen G, Graem N, et al. OCT2, SSX and SAGE1 reveal the phenotypic heterogeneity of spermatocytic seminoma reflecting distinct subpopulations of spermatogonia. J Pathol. 2011;224:473-83 pubmed publisher
    Spermatocytic seminoma (SS) is a rare testicular neoplasm that occurs predominantly in older men...
  64. Wermann H, Stoop H, Gillis A, Honecker F, van Gurp R, Ammerpohl O, et al. Global DNA methylation in fetal human germ cells and germ cell tumours: association with differentiation and cisplatin resistance. J Pathol. 2010;221:433-42 pubmed publisher
    ..Among the genes revealing changes, interesting targets were identified: ie demethylation of KLF11, a putative tumour suppressor gene, and hypermethylation of CFLAR, a gene previously described in treatment resistance in GCTs...
  65. Chevalier N, Barlier A, Roche C, Mograbi B, Camparo P, Devouassoux Shisheboran M, et al. RET gene mutations are not involved in the origin of human testicular seminoma. Int J Androl. 2010;33:848-52 pubmed publisher
    ..Over-expression of GDNF in adult transgenic mice induces the development of testicular tumours that mimic human seminoma, the most frequent testicular germ cell tumour...
  66. Skliarenko J, Vesprini D, Warde P. Stage I seminoma: what should a practicing uro-oncologist do in 2009?. Int J Urol. 2009;16:544-51 pubmed publisher
    ..In the United States in 2008, approximately 4800 cases of seminoma, approximately 4100 of which were stage I disease were projected after the completion of staging investigations...
  67. Maruta S, Shida Y, Takehara K, Onita T, Igawa T, Sakai H. [A case report of bilateral spermatocytic seminoma]. Hinyokika Kiyo. 2011;57:525-8 pubmed
    Spermatocytic seminoma is a rare germ cell tumor which was first described by Masson in 1946. We experienced a case of bilateral spermatocytic seminoma. A 56-year-old man presented with painless swelling of left scrotal contents...
  68. Aparicio J, Maroto P, del Muro X, Gumà J, Sánchez Muñoz A, Margeli M, et al. Risk-adapted treatment in clinical stage I testicular seminoma: the third Spanish Germ Cell Cancer Group study. J Clin Oncol. 2011;29:4677-81 pubmed publisher
    To confirm the efficacy of a risk-adapted treatment approach for patients with clinical stage I seminoma. The aim was to reduce both the risk of relapse and the proportion of patients receiving adjuvant chemotherapy while maintaining a ..
  69. Bush J, Gardiner D, Palmer J, Rajpert De Meyts E, Veeramachaneni D. Testicular germ cell tumours in dogs are predominantly of spermatocytic seminoma type and are frequently associated with somatic cell tumours. Int J Androl. 2011;34:e288-95; discussion e295 pubmed publisher
    ..Canine spermatocytic seminomas may provide a useful model for this rare human neoplasm...
  70. Portas T, Hildebrandt T, Bryant B, Goritz F, Hermes R. Seminoma in a southern black rhinoceros (Diceros bicornis minor): diagnosis, surgical management and effect on fertility. Aust Vet J. 2010;88:57-60 pubmed publisher
    ..Hemi-castration was performed to excise the affected testis and a pathological diagnosis of a seminoma was made...
  71. Port M, Wang Y, Schmelz H, Pottek T, Meineke V, Ruf C, et al. A gene signature of primary tumor identifies metastasized seminoma. Urol Oncol. 2011;29:764-73 pubmed publisher
    The aim of this study was the prediction of metastatic status in seminoma based on examination of the primary tumor.
  72. Ayyanar K, Blackman S, Chordas C, Frazier L, Kieran M. Metachronous mediastinal seminoma occurring after intracranial germinoma in an adolescent. J Pediatr Hematol Oncol. 2009;31:861-4 pubmed publisher
    We report a case of a mediastinal seminoma occurring 19 months after the resolution of a pineal germinoma...
  73. Ferranti F, D Anselmi F, Caruso M, Lei V, Dinicola S, Pasqualato A, et al. TCam-2 seminoma cells exposed to egg-derived microenvironment modify their shape, adhesive pattern and migratory behaviour: a molecular and morphometric analysis. PLoS ONE. 2013;8:e76192 pubmed publisher
    b>Seminoma is one of the most common Testicular Germ Cell Tumours that originates during embryonic development due to an alteration of the local niche that in turn results in a delayed or blocked differentiation of Primordial Germ Cells...
  74. Ruf C, Schmelz H, Port M, Wagner W, Matthies C, Muller Myhsok B, et al. Discriminating metastasised from non-metastasised seminoma based on transcriptional changes in primary tumours using NGS. Br J Cancer. 2014;110:2738-46 pubmed publisher
    We aimed to better discriminate (occult) metastasised from non-metastasised seminoma based on transcriptional changes of small RNAs in the primary tumour.